PLPP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1biotin metabolic process (GO:0006768)6.66557247
2water-soluble vitamin biosynthetic process (GO:0042364)4.98635189
3response to pheromone (GO:0019236)4.93169401
4intestinal cholesterol absorption (GO:0030299)4.78363732
5regulation of sarcomere organization (GO:0060297)4.60759303
6regulation of mitochondrial fission (GO:0090140)4.59601056
7negative regulation of heart growth (GO:0061117)4.58856863
8negative regulation of cardiac muscle tissue growth (GO:0055022)4.58856863
9COPII vesicle coating (GO:0048208)4.36407679
10positive regulation of mitochondrial fission (GO:0090141)4.28157522
11phenylpropanoid metabolic process (GO:0009698)4.28099313
12vitamin biosynthetic process (GO:0009110)4.26294217
13regulation of short-term neuronal synaptic plasticity (GO:0048172)4.21744443
14short-chain fatty acid metabolic process (GO:0046459)4.19612577
15locomotory exploration behavior (GO:0035641)4.19494605
16synaptic vesicle maturation (GO:0016188)4.18333568
17cellular glucuronidation (GO:0052695)4.11936086
18cellular potassium ion homeostasis (GO:0030007)4.10804056
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.05969479
20positive regulation of receptor biosynthetic process (GO:0010870)4.05843560
21ectodermal placode formation (GO:0060788)4.05769582
22positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.03990928
23intestinal absorption (GO:0050892)4.02061200
24glutamate secretion (GO:0014047)3.97162360
25regulation of cholesterol metabolic process (GO:0090181)3.93819838
26regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.91582247
27uronic acid metabolic process (GO:0006063)3.90310295
28glucuronate metabolic process (GO:0019585)3.90310295
29mRNA modification (GO:0016556)3.87096599
30synaptic vesicle exocytosis (GO:0016079)3.82193831
31doxorubicin metabolic process (GO:0044598)3.76415717
32daunorubicin metabolic process (GO:0044597)3.76415717
33polyketide metabolic process (GO:0030638)3.76415717
34vocalization behavior (GO:0071625)3.74836886
35auditory receptor cell differentiation (GO:0042491)3.74065898
36regulation of synaptic vesicle exocytosis (GO:2000300)3.71883466
37snRNA processing (GO:0016180)3.67065478
38negative regulation of fibrinolysis (GO:0051918)3.66892424
39regulation of fibrinolysis (GO:0051917)3.66421548
40sodium ion export (GO:0071436)3.61015956
41receptor recycling (GO:0001881)3.58555106
42mitochondrial fission (GO:0000266)3.54257521
43fat-soluble vitamin biosynthetic process (GO:0042362)3.53953245
44negative regulation of sterol transport (GO:0032372)3.52227273
45negative regulation of cholesterol transport (GO:0032375)3.52227273
46regulation of long-term neuronal synaptic plasticity (GO:0048169)3.51390544
47snRNA metabolic process (GO:0016073)3.50615481
48bile acid metabolic process (GO:0008206)3.50350104
49blood coagulation, intrinsic pathway (GO:0007597)3.47182498
50regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.46872161
51synaptic vesicle docking involved in exocytosis (GO:0016081)3.46096987
52neuronal action potential propagation (GO:0019227)3.45602348
53regulation of glutamate receptor signaling pathway (GO:1900449)3.43211879
54histone H4 deacetylation (GO:0070933)3.39429948
55regulation of DNA methylation (GO:0044030)3.39223451
56regulation of synaptic vesicle transport (GO:1902803)3.39161335
57ionotropic glutamate receptor signaling pathway (GO:0035235)3.39022594
58aminoglycoside antibiotic metabolic process (GO:0030647)3.36174879
59tRNA methylation (GO:0030488)3.34934954
60regulation of neuronal synaptic plasticity (GO:0048168)3.32287023
61microtubule depolymerization (GO:0007019)3.27655898
62NADH metabolic process (GO:0006734)3.26069361
63exploration behavior (GO:0035640)3.24766216
64regulation of bile acid biosynthetic process (GO:0070857)3.23730451
65neurotransmitter secretion (GO:0007269)3.22414714
66activation of protein kinase A activity (GO:0034199)3.21628631
67cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.20792465
68COPI coating of Golgi vesicle (GO:0048205)3.18763734
69Golgi transport vesicle coating (GO:0048200)3.18763734
70regulation of plasminogen activation (GO:0010755)3.17806968
71epoxygenase P450 pathway (GO:0019373)3.14906184
72regulation of protein activation cascade (GO:2000257)3.11231188
73nitrogen cycle metabolic process (GO:0071941)3.11157181
74very-low-density lipoprotein particle assembly (GO:0034379)3.08694051
75cellular response to prostaglandin stimulus (GO:0071379)3.08592899
76glutamate receptor signaling pathway (GO:0007215)3.07774062
77response to prostaglandin E (GO:0034695)3.06178621
78L-phenylalanine catabolic process (GO:0006559)3.04927382
79erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.04927382
80erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.04442749
81L-phenylalanine metabolic process (GO:0006558)3.04442749
82protein carboxylation (GO:0018214)2.99320101
83peptidyl-glutamic acid carboxylation (GO:0017187)2.99320101
84chemosensory behavior (GO:0007635)2.98619470
85establishment of melanosome localization (GO:0032401)2.98430766
86neurofilament cytoskeleton organization (GO:0060052)2.95258616
87protein localization to synapse (GO:0035418)2.94420311
88regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.94246993
89regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.94172439
90negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.92507640
91cellular sodium ion homeostasis (GO:0006883)2.92457795
92regulation of excitatory postsynaptic membrane potential (GO:0060079)2.91067099
93urea metabolic process (GO:0019627)2.90450591
94long term synaptic depression (GO:0060292)2.88737873
95regulation of synapse structural plasticity (GO:0051823)2.88434425
96mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.87147184
97synaptic transmission, glutamatergic (GO:0035249)2.86907959
98melanosome transport (GO:0032402)2.86868239
99layer formation in cerebral cortex (GO:0021819)2.86363513
100regulation of helicase activity (GO:0051095)2.85566698
101rRNA catabolic process (GO:0016075)2.84714110
102regulation of complement activation (GO:0030449)2.84467337
103response to prostaglandin (GO:0034694)2.84062194
104eyelid development in camera-type eye (GO:0061029)2.83145729
105positive regulation of membrane potential (GO:0045838)2.81886747
106regulation of clathrin-mediated endocytosis (GO:2000369)2.81858557
107histone H3 deacetylation (GO:0070932)2.81491667
108establishment of pigment granule localization (GO:0051905)2.81056626
109regulation of synaptic plasticity (GO:0048167)2.80839200
110urate metabolic process (GO:0046415)2.80073468
111long-term memory (GO:0007616)2.79698087
112potassium ion import (GO:0010107)2.79556765
113regulation of dendritic spine morphogenesis (GO:0061001)2.78941350
114regulation of ARF protein signal transduction (GO:0032012)2.78694064
115phospholipid dephosphorylation (GO:0046839)2.78354440
116regulation of glycogen (starch) synthase activity (GO:2000465)2.77350488
117oxaloacetate metabolic process (GO:0006107)2.75748852
118proline transport (GO:0015824)2.75629073
119gamma-aminobutyric acid transport (GO:0015812)2.75460392
120membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.75412493
121regulation of actin nucleation (GO:0051125)2.74987915
122cell communication by electrical coupling (GO:0010644)2.74929187
123exogenous drug catabolic process (GO:0042738)2.74626132
124glyoxylate metabolic process (GO:0046487)2.74576245
125proline biosynthetic process (GO:0006561)2.74352145
126interkinetic nuclear migration (GO:0022027)2.72818717
127vesicle transport along microtubule (GO:0047496)2.70872965
128neuron-neuron synaptic transmission (GO:0007270)2.70588807
129histone deubiquitination (GO:0016578)2.69877755
130regulation of postsynaptic membrane potential (GO:0060078)2.69856923
131negative regulation of glycogen biosynthetic process (GO:0045719)2.69603345
132G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.69324296
133pigment granule transport (GO:0051904)2.69229935
134positive regulation of vesicle fusion (GO:0031340)2.69177003
135definitive hemopoiesis (GO:0060216)2.68858776
136glutamate metabolic process (GO:0006536)2.68702812
137cerebellar Purkinje cell differentiation (GO:0021702)2.68174867
138ncRNA catabolic process (GO:0034661)2.67105408
139long-term synaptic potentiation (GO:0060291)2.67011092
140gamma-aminobutyric acid signaling pathway (GO:0007214)2.66870165
141neurotransmitter-gated ion channel clustering (GO:0072578)2.66165077
142detection of calcium ion (GO:0005513)2.65875644
143dendritic spine morphogenesis (GO:0060997)2.64117911
144regulation of RIG-I signaling pathway (GO:0039535)2.63990159
145phosphate ion transmembrane transport (GO:0035435)2.63925270
146urea cycle (GO:0000050)2.62275788
147drug catabolic process (GO:0042737)2.61755916
148neurotransmitter transport (GO:0006836)2.60745217
149phosphate ion transport (GO:0006817)2.60497522
150sulfur amino acid catabolic process (GO:0000098)2.60347348
151membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.59491904
152regulation of cholesterol homeostasis (GO:2000188)2.58668804
153cobalamin metabolic process (GO:0009235)2.58384371
154regulation of keratinocyte differentiation (GO:0045616)2.57084845
155phosphatidylinositol dephosphorylation (GO:0046856)2.56538406
156nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.56481767
157bile acid biosynthetic process (GO:0006699)2.54474907
158purine ribonucleotide transport (GO:0015868)2.54395799
159protein targeting to Golgi (GO:0000042)2.53768885
160dendritic spine organization (GO:0097061)2.51901734
161positive regulation of neurotransmitter secretion (GO:0001956)2.51679976
162cell communication involved in cardiac conduction (GO:0086065)2.51191981
163potassium ion homeostasis (GO:0055075)2.50078399
164regulation of vesicle fusion (GO:0031338)2.49614709
165positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.49389943
166neuron cell-cell adhesion (GO:0007158)2.47019841
167regulation of neurotransmitter levels (GO:0001505)2.46695030
168innervation (GO:0060384)2.45037658
169suckling behavior (GO:0001967)2.41578829
170positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.40891601
171neuromuscular process controlling balance (GO:0050885)2.39671137
172regulation of sodium ion transmembrane transporter activity (GO:2000649)2.37267281
173regulation of dendritic spine development (GO:0060998)2.36445093
174membrane repolarization (GO:0086009)2.33740571
175retrograde transport, vesicle recycling within Golgi (GO:0000301)2.33466827
176establishment of protein localization to Golgi (GO:0072600)2.32971699
177regulation of female receptivity (GO:0045924)2.32583197
178nerve growth factor signaling pathway (GO:0038180)2.32343175
179positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.31922734
180membrane repolarization during action potential (GO:0086011)2.30503957
181neuron recognition (GO:0008038)2.27880355
182mating behavior (GO:0007617)2.27677616
183regulation of amyloid precursor protein catabolic process (GO:1902991)2.27221996
184positive regulation of synapse maturation (GO:0090129)2.26203104
185membrane depolarization (GO:0051899)2.24623098
186positive regulation of neurotransmitter transport (GO:0051590)2.24611266
187regulation of neurotransmitter secretion (GO:0046928)2.23471555
188regulation of calcium ion-dependent exocytosis (GO:0017158)2.22722074
189cochlea development (GO:0090102)2.22217063
190response to histamine (GO:0034776)2.21514559
191alanine transport (GO:0032328)2.21062544
192regulation of synaptic transmission, glutamatergic (GO:0051966)2.20283745
193relaxation of cardiac muscle (GO:0055119)2.19479768
194positive regulation of synaptic transmission (GO:0050806)2.17706086
195dicarboxylic acid biosynthetic process (GO:0043650)2.16236521
196regulation of synaptic transmission (GO:0050804)2.15819440
197positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.15437093
198calcium ion-dependent exocytosis (GO:0017156)2.15330285
199regulation of ion transmembrane transporter activity (GO:0032412)2.15190480
200positive regulation of exocytosis (GO:0045921)2.14327408

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human5.92433258
2RBPJ_22232070_ChIP-Seq_NCS_Mouse5.76326038
3IGF1R_20145208_ChIP-Seq_DFB_Human4.44612715
4EZH2_22144423_ChIP-Seq_EOC_Human4.21433794
5ESR1_15608294_ChIP-ChIP_MCF-7_Human3.38583813
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.29254574
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.51780884
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.42566478
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.36856591
10PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.34549164
11IRF1_19129219_ChIP-ChIP_H3396_Human2.34228015
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.33460073
13GBX2_23144817_ChIP-Seq_PC3_Human2.30406935
14PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.24215113
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.23193067
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.18573715
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.16896165
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.15047831
19CIITA_25753668_ChIP-Seq_RAJI_Human2.14302227
20DROSHA_22980978_ChIP-Seq_HELA_Human2.08630659
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.07234789
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.07234789
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.06510136
24ZFX_18555785_ChIP-Seq_MESCs_Mouse2.04780125
25PKCTHETA_26484144_Chip-Seq_BREAST_Human2.04062829
26TCF4_18268006_ChIP-ChIP_LS174T_Human2.03500346
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.01763118
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.00527567
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.96458989
30REST_21632747_ChIP-Seq_MESCs_Mouse1.94100919
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.91155605
32CHD1_26751641_Chip-Seq_LNCaP_Human1.87769418
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.87754062
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.87335852
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.85973918
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.83464574
37FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.81926272
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.80479491
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.80042683
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.78357612
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.73591296
42FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.71657789
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.70733880
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69381983
45CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.69047345
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68792555
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63670901
48CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.63147179
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.61309281
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.57131972
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56540060
52EGR1_23403033_ChIP-Seq_LIVER_Mouse1.54113241
53ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.52866557
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51097850
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49325638
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.49124022
57AR_21572438_ChIP-Seq_LNCaP_Human1.43847880
58EED_16625203_ChIP-ChIP_MESCs_Mouse1.43408665
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42915294
60KDM5A_27292631_Chip-Seq_BREAST_Human1.41905639
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39811719
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.39629749
63SOX2_27498859_Chip-Seq_STOMACH_Mouse1.39183131
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39181814
65GABP_19822575_ChIP-Seq_HepG2_Human1.39064552
66FOXP3_21729870_ChIP-Seq_TREG_Human1.36296351
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.34320901
68FOXA1_25552417_ChIP-Seq_VCAP_Human1.33688042
69LXR_22158963_ChIP-Seq_LIVER_Mouse1.32691957
70SMAD4_21799915_ChIP-Seq_A2780_Human1.32195685
71AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.31231557
72MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31123136
73RXR_22158963_ChIP-Seq_LIVER_Mouse1.30181236
74EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29344213
75SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.28713193
76ZNF274_21170338_ChIP-Seq_K562_Hela1.27689504
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.27293278
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26734208
79AR_21909140_ChIP-Seq_LNCAP_Human1.26412730
80FUS_26573619_Chip-Seq_HEK293_Human1.25939613
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24093666
82BCAT_22108803_ChIP-Seq_LS180_Human1.22805367
83RNF2_27304074_Chip-Seq_NSC_Mouse1.20944314
84FOXO3_23340844_ChIP-Seq_DLD1_Human1.20840427
85HNF4A_19822575_ChIP-Seq_HepG2_Human1.20798432
86CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19828006
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19400886
88PIAS1_25552417_ChIP-Seq_VCAP_Human1.19345144
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19332942
90WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19173485
91CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.17342237
92TAF15_26573619_Chip-Seq_HEK293_Human1.17036383
93MYC_22102868_ChIP-Seq_BL_Human1.15337510
94NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14826373
95DCP1A_22483619_ChIP-Seq_HELA_Human1.14733016
96NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14444884
97AR_25329375_ChIP-Seq_VCAP_Human1.13922164
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.13552877
99ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12106691
100RXR_22108803_ChIP-Seq_LS180_Human1.11911047
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11214113
102NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10933854
103HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.10897052
104SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10845551
105NANOG_21062744_ChIP-ChIP_HESCs_Human1.09616240
106AHR_22903824_ChIP-Seq_MCF-7_Human1.08736505
107FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08712254
108TP53_16413492_ChIP-PET_HCT116_Human1.07915794
109KDM2B_26808549_Chip-Seq_K562_Human1.07831002
110SOX2_21211035_ChIP-Seq_LN229_Gbm1.06650698
111FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.04465332
112WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04302550
113DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03994371
114TAL1_26923725_Chip-Seq_HPCs_Mouse1.03299318
115SMAD3_21741376_ChIP-Seq_EPCs_Human1.03003273
116PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02976484
117E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02252505
118BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01738172
119NOTCH1_21737748_ChIP-Seq_TLL_Human1.01434732
120FOXA2_19822575_ChIP-Seq_HepG2_Human1.00909728
121REST_19997604_ChIP-ChIP_NEURONS_Mouse1.00676423
122RING1B_27294783_Chip-Seq_ESCs_Mouse1.00223437
123PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99957794
124PPARA_22158963_ChIP-Seq_LIVER_Mouse0.99920939
125ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99330033
126EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99290260
127ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99224659
128ESR2_21235772_ChIP-Seq_MCF-7_Human0.99222751
129AR_19668381_ChIP-Seq_PC3_Human0.99201513
130TP53_18474530_ChIP-ChIP_U2OS_Human0.98756556
131ZNF263_19887448_ChIP-Seq_K562_Human0.98353343
132THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97139087
133SMAD3_21741376_ChIP-Seq_HESCs_Human0.97083500
134EP300_21415370_ChIP-Seq_HL-1_Mouse0.96768179
135GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96219447
136P300_19829295_ChIP-Seq_ESCs_Human0.95747818
137SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95566759
138GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.94796388
139AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94476590
140SMAD4_21741376_ChIP-Seq_HESCs_Human0.94367551
141NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93305944
142NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93305944
143STAT3_23295773_ChIP-Seq_U87_Human0.93263688
144FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92893010
145ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92022464
146ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91711269
147GATA6_25053715_ChIP-Seq_YYC3_Human0.91512602
148YY1_21170310_ChIP-Seq_MESCs_Mouse0.91366584
149OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91352791
150TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90895622
151ESR1_20079471_ChIP-ChIP_T-47D_Human0.90852699
152SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90123673
153TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89597298
154ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89275825
155MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.88978302
156TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88690042
157RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.86630761
158CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86434230
159RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.84854925
160GATA4_25053715_ChIP-Seq_YYC3_Human0.84504497
161SMAD4_21741376_ChIP-Seq_EPCs_Human0.83954435
162MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83699559
163CREB1_26743006_Chip-Seq_LNCaP_Human0.83689311
164SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83251039
165KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82941470
166TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.81883902
167CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.81671100
168NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81546159
169BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.80855498
170CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.80579059
171FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.80530355
172YAP1_20516196_ChIP-Seq_MESCs_Mouse0.80222409
173ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80036258
174PCGF2_27294783_Chip-Seq_NPCs_Mouse0.79539900
175TTF2_22483619_ChIP-Seq_HELA_Human0.79438441
176ERG_20887958_ChIP-Seq_HPC-7_Mouse0.78604932
177ELK4_26923725_Chip-Seq_MESODERM_Mouse0.78515956
178CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.78329352
179GATA3_21867929_ChIP-Seq_CD8_Mouse0.77195521
180MYC_18555785_ChIP-Seq_MESCs_Mouse0.76888616
181HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.75582752
182NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.74961182

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.61945705
2MP0003635_abnormal_synaptic_transmissio3.45292720
3MP0003880_abnormal_central_pattern3.42264357
4MP0004270_analgesia3.04994098
5MP0003122_maternal_imprinting3.03296363
6MP0010234_abnormal_vibrissa_follicle2.94807898
7MP0003567_abnormal_fetal_cardiomyocyte2.86613821
8MP0002063_abnormal_learning/memory/cond2.64527730
9MP0009745_abnormal_behavioral_response2.63011967
10MP0002822_catalepsy2.58802988
11MP0009780_abnormal_chondrocyte_physiolo2.51829389
12MP0002909_abnormal_adrenal_gland2.46883059
13MP0002064_seizures2.42185961
14MP0003787_abnormal_imprinting2.41567051
15MP0003123_paternal_imprinting2.40277930
16MP0003329_amyloid_beta_deposits2.39154261
17MP0001188_hyperpigmentation2.36549830
18MP0004742_abnormal_vestibular_system2.28270679
19MP0005360_urolithiasis2.13232500
20MP0001501_abnormal_sleep_pattern2.10737947
21MP0002572_abnormal_emotion/affect_behav2.07311475
22MP0002139_abnormal_hepatobiliary_system2.06538818
23MP0001968_abnormal_touch/_nociception2.01717791
24MP0009046_muscle_twitch1.96060029
25MP0004043_abnormal_pH_regulation1.92752722
26MP0003806_abnormal_nucleotide_metabolis1.92612162
27MP0002272_abnormal_nervous_system1.89258396
28MP0003121_genomic_imprinting1.81728899
29MP0008877_abnormal_DNA_methylation1.78694535
30MP0009384_cardiac_valve_regurgitation1.77810704
31MP0000013_abnormal_adipose_tissue1.74160534
32MP0001764_abnormal_homeostasis1.70035702
33MP0008875_abnormal_xenobiotic_pharmacok1.68954866
34MP0003195_calcinosis1.67919504
35MP0001486_abnormal_startle_reflex1.67473079
36MP0000516_abnormal_urinary_system1.66682962
37MP0005367_renal/urinary_system_phenotyp1.66682962
38MP0008569_lethality_at_weaning1.66147949
39MP0003718_maternal_effect1.62923914
40MP0005085_abnormal_gallbladder_physiolo1.57237358
41MP0001765_abnormal_ion_homeostasis1.57072811
42MP0003890_abnormal_embryonic-extraembry1.56424470
43MP0002009_preneoplasia1.54475393
44MP0002734_abnormal_mechanical_nocicepti1.51795420
45MP0002837_dystrophic_cardiac_calcinosis1.50692875
46MP0000604_amyloidosis1.50203925
47MP0004130_abnormal_muscle_cell1.49816952
48MP0005365_abnormal_bile_salt1.49079200
49MP0001440_abnormal_grooming_behavior1.48198495
50MP0003172_abnormal_lysosome_physiology1.46803579
51MP0008961_abnormal_basal_metabolism1.46627481
52MP0000465_gastrointestinal_hemorrhage1.45600869
53MP0003633_abnormal_nervous_system1.45365117
54MP0005535_abnormal_body_temperature1.44997525
55MP0005075_abnormal_melanosome_morpholog1.44974471
56MP0003879_abnormal_hair_cell1.44958831
57MP0000490_abnormal_crypts_of1.42938865
58MP0010329_abnormal_lipoprotein_level1.42389946
59MP0002736_abnormal_nociception_after1.40519326
60MP0010386_abnormal_urinary_bladder1.40095523
61MP0005423_abnormal_somatic_nervous1.37421309
62MP0004233_abnormal_muscle_weight1.36525679
63MP0003300_gastrointestinal_ulcer1.36051027
64MP0002796_impaired_skin_barrier1.29710737
65MP0005167_abnormal_blood-brain_barrier1.28712638
66MP0002733_abnormal_thermal_nociception1.28448142
67MP0002067_abnormal_sensory_capabilities1.28195510
68MP0003693_abnormal_embryo_hatching1.26926422
69MP0000566_synostosis1.25605484
70MP0003075_altered_response_to1.24829708
71MP0005501_abnormal_skin_physiology1.24150509
72MP0005645_abnormal_hypothalamus_physiol1.20183976
73MP0003941_abnormal_skin_development1.19999372
74MP0003943_abnormal_hepatobiliary_system1.19719852
75MP0001970_abnormal_pain_threshold1.19705120
76MP0001666_abnormal_nutrient_absorption1.18497278
77MP0004858_abnormal_nervous_system1.18264357
78MP0004811_abnormal_neuron_physiology1.16470874
79MP0003252_abnormal_bile_duct1.15316022
80MP0005386_behavior/neurological_phenoty1.15130219
81MP0004924_abnormal_behavior1.15130219
82MP0002877_abnormal_melanocyte_morpholog1.14783556
83MP0000609_abnormal_liver_physiology1.13890014
84MP0002557_abnormal_social/conspecific_i1.13800516
85MP0002735_abnormal_chemical_nociception1.13132569
86MP0001919_abnormal_reproductive_system1.12731486
87MP0004885_abnormal_endolymph1.11770666
88MP0001984_abnormal_olfaction1.09830613
89MP0006292_abnormal_olfactory_placode1.09825141
90MP0008872_abnormal_physiological_respon1.09409693
91MP0003763_abnormal_thymus_physiology1.08321517
92MP0003221_abnormal_cardiomyocyte_apopto1.07914063
93MP0002138_abnormal_hepatobiliary_system1.07624147
94MP0005332_abnormal_amino_acid1.07384659
95MP0001873_stomach_inflammation1.07198806
96MP0005248_abnormal_Harderian_gland1.06333306
97MP0003191_abnormal_cellular_cholesterol1.06326807
98MP0002118_abnormal_lipid_homeostasis1.06092173
99MP0003690_abnormal_glial_cell1.00715713
100MP0004484_altered_response_of0.98167937
101MP0000003_abnormal_adipose_tissue0.97427671
102MP0003631_nervous_system_phenotype0.96880340
103MP0002078_abnormal_glucose_homeostasis0.96162118
104MP0002184_abnormal_innervation0.95513127
105MP0004185_abnormal_adipocyte_glucose0.95001731
106MP0002066_abnormal_motor_capabilities/c0.94323758
107MP0008874_decreased_physiological_sensi0.94314348
108MP0002876_abnormal_thyroid_physiology0.94102573
109MP0001502_abnormal_circadian_rhythm0.92663113
110MP0009672_abnormal_birth_weight0.90265935
111MP0001944_abnormal_pancreas_morphology0.89033945
112MP0005646_abnormal_pituitary_gland0.86461764
113MP0005584_abnormal_enzyme/coenzyme_acti0.84967204
114MP0004215_abnormal_myocardial_fiber0.84522126
115MP0005375_adipose_tissue_phenotype0.84320360
116MP0001664_abnormal_digestion0.83635696
117MP0005666_abnormal_adipose_tissue0.83626813
118MP0003868_abnormal_feces_composition0.83420503
119MP0002069_abnormal_eating/drinking_beha0.83377938
120MP0005409_darkened_coat_color0.82502327
121MP0002693_abnormal_pancreas_physiology0.80900537
122MP0005084_abnormal_gallbladder_morpholo0.80728896
123MP0003183_abnormal_peptide_metabolism0.79674153
124MP0002971_abnormal_brown_adipose0.79581392
125MP0000462_abnormal_digestive_system0.79523208
126MP0000955_abnormal_spinal_cord0.77735159
127MP0004510_myositis0.76276628
128MP0002882_abnormal_neuron_morphology0.76143957
129MP0001915_intracranial_hemorrhage0.75812759
130MP0009643_abnormal_urine_homeostasis0.74787264
131MP0000598_abnormal_liver_morphology0.74233819
132MP0005408_hypopigmentation0.74168483
133MP0002234_abnormal_pharynx_morphology0.74127761
134MP0003315_abnormal_perineum_morphology0.73648199
135MP0004085_abnormal_heartbeat0.73016108
136MP0005636_abnormal_mineral_homeostasis0.72915041
137MP0001177_atelectasis0.71842540
138MP0004264_abnormal_extraembryonic_tissu0.70605742
139MP0005166_decreased_susceptibility_to0.70554601
140MP0002229_neurodegeneration0.70511951
141MP0004197_abnormal_fetal_growth/weight/0.70499741
142MP0000778_abnormal_nervous_system0.68748582
143MP0003385_abnormal_body_wall0.68599775
144MP0002090_abnormal_vision0.68564859
145MP0002098_abnormal_vibrissa_morphology0.64513426
146MP0001727_abnormal_embryo_implantation0.64258108
147MP0003699_abnormal_female_reproductive0.63088775
148MP0005310_abnormal_salivary_gland0.62883710
149MP0001529_abnormal_vocalization0.62819814
150MP0005220_abnormal_exocrine_pancreas0.62526546
151MP0002697_abnormal_eye_size0.61375352
152MP0000477_abnormal_intestine_morphology0.61236507
153MP0009703_decreased_birth_body0.60624673
154MP0002928_abnormal_bile_duct0.58535721
155MP0005410_abnormal_fertilization0.56800496
156MP0002233_abnormal_nose_morphology0.55676311
157MP0000653_abnormal_sex_gland0.55162148
158MP0001485_abnormal_pinna_reflex0.53940945
159MP0004381_abnormal_hair_follicle0.53329559
160MP0000681_abnormal_thyroid_gland0.52549577
161MP0009642_abnormal_blood_homeostasis0.52063852
162MP0000538_abnormal_urinary_bladder0.51098642
163MP0005376_homeostasis/metabolism_phenot0.50551705
164MP0009250_abnormal_appendicular_skeleto0.48485832

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinemia (HP:0002154)6.27450643
2Focal motor seizures (HP:0011153)5.98686795
3Conjugated hyperbilirubinemia (HP:0002908)5.02229013
4Myokymia (HP:0002411)4.65422296
5Prolonged partial thromboplastin time (HP:0003645)4.56433748
6Visual hallucinations (HP:0002367)4.41075345
7Renal cortical cysts (HP:0000803)4.29309537
8Abnormality of serine family amino acid metabolism (HP:0010894)4.21901058
9Abnormality of glycine metabolism (HP:0010895)4.21901058
10Focal seizures (HP:0007359)4.16150999
11Limb hypertonia (HP:0002509)3.63622868
12Absence seizures (HP:0002121)3.59445835
13Methylmalonic acidemia (HP:0002912)3.54293895
14Epileptic encephalopathy (HP:0200134)3.43098686
15Abnormal foot bone ossification (HP:0010675)3.42716795
16Joint hemorrhage (HP:0005261)3.42108537
17Atonic seizures (HP:0010819)3.39100851
18Hyperammonemia (HP:0001987)3.32437513
19Osteomalacia (HP:0002749)3.30800804
20Hyperglycinuria (HP:0003108)3.22403429
21Nephrogenic diabetes insipidus (HP:0009806)3.21039860
22Action tremor (HP:0002345)3.18912775
23Papillary thyroid carcinoma (HP:0002895)3.17607403
24Dialeptic seizures (HP:0011146)3.14285473
25Cerebral inclusion bodies (HP:0100314)3.14069294
26Cheilitis (HP:0100825)3.11535931
27Abnormality of the intrinsic pathway (HP:0010989)3.10648293
28Generalized tonic-clonic seizures (HP:0002069)3.03241059
29Hypobetalipoproteinemia (HP:0003563)2.97565767
30Ketoacidosis (HP:0001993)2.94038239
31Hyperventilation (HP:0002883)2.90744104
32Neurofibrillary tangles (HP:0002185)2.89107390
33Papilledema (HP:0001085)2.85996954
34Fat malabsorption (HP:0002630)2.85846528
35Anxiety (HP:0000739)2.85019132
36Impaired social interactions (HP:0000735)2.84130209
37Abnormal social behavior (HP:0012433)2.84130209
38Supranuclear gaze palsy (HP:0000605)2.80917557
39Abnormality of vitamin metabolism (HP:0100508)2.78812736
40Intention tremor (HP:0002080)2.74916957
41Poor eye contact (HP:0000817)2.73696091
42Depression (HP:0000716)2.71599755
43Abnormality of monocarboxylic acid metabolism (HP:0010996)2.67741391
44Ventricular fibrillation (HP:0001663)2.64971615
45Progressive cerebellar ataxia (HP:0002073)2.64880100
46Dysmetria (HP:0001310)2.64638003
47Febrile seizures (HP:0002373)2.59907417
48Hyperphosphaturia (HP:0003109)2.59219427
49Hypoglycemic coma (HP:0001325)2.57557028
50Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.56676012
51Impaired vibration sensation in the lower limbs (HP:0002166)2.54433248
52Increased circulating renin level (HP:0000848)2.54289441
53Hemiplegia (HP:0002301)2.52790608
54Hypercholesterolemia (HP:0003124)2.52438981
55Tachypnea (HP:0002789)2.52425895
56Status epilepticus (HP:0002133)2.49270850
57Pancreatic islet-cell hyperplasia (HP:0004510)2.47782389
58Agitation (HP:0000713)2.46717403
59Abnormality of oral frenula (HP:0000190)2.46388713
60Methylmalonic aciduria (HP:0012120)2.45529812
61Scanning speech (HP:0002168)2.45210138
62Truncal ataxia (HP:0002078)2.45082105
63Gout (HP:0001997)2.41992964
64Abnormality of the vitamin B12 metabolism (HP:0004341)2.41954751
65Postural instability (HP:0002172)2.40624345
66Dysdiadochokinesis (HP:0002075)2.40150530
67Ketosis (HP:0001946)2.37297118
68Metabolic acidosis (HP:0001942)2.36040416
69Abnormality of vitamin B metabolism (HP:0004340)2.33973422
70Abnormal eating behavior (HP:0100738)2.32799361
71Abnormal urine phosphate concentration (HP:0012599)2.31108916
72Hyperactive renin-angiotensin system (HP:0000841)2.29731987
73Impaired smooth pursuit (HP:0007772)2.26137281
74Steatorrhea (HP:0002570)2.25916427
75Clitoromegaly (HP:0000057)2.24772821
76Gaze-evoked nystagmus (HP:0000640)2.23424537
77Widely patent fontanelles and sutures (HP:0004492)2.22369072
78Menstrual irregularities (HP:0000858)2.21851412
79Hepatoblastoma (HP:0002884)2.21287951
80Global brain atrophy (HP:0002283)2.19719278
81Intrahepatic cholestasis (HP:0001406)2.17427975
82Dicarboxylic aciduria (HP:0003215)2.15903537
83Abnormality of dicarboxylic acid metabolism (HP:0010995)2.15903537
84Dysmetric saccades (HP:0000641)2.15902614
85Progressive inability to walk (HP:0002505)2.14201071
86Proximal tubulopathy (HP:0000114)2.14098235
87Gait imbalance (HP:0002141)2.13236351
88Abnormality of binocular vision (HP:0011514)2.12879085
89Diplopia (HP:0000651)2.12879085
90Amblyopia (HP:0000646)2.11561210
91Congenital primary aphakia (HP:0007707)2.09576252
92Mutism (HP:0002300)2.09555461
93Germ cell neoplasia (HP:0100728)2.09535098
94Stereotypic behavior (HP:0000733)2.09288839
95Megalencephaly (HP:0001355)2.07873680
96Thickened nuchal skin fold (HP:0000474)2.07057747
97Abnormality of glutamine family amino acid metabolism (HP:0010902)2.06454077
98Hemiparesis (HP:0001269)2.06354463
99Epileptiform EEG discharges (HP:0011182)2.06273084
100Hip dysplasia (HP:0001385)2.06148703
101Decreased circulating renin level (HP:0003351)2.05375352
102Abnormality of aromatic amino acid family metabolism (HP:0004338)2.05215415
103Severe Myopia (HP:0011003)2.03677626
104Broad-based gait (HP:0002136)2.03447818
105Renal tubular dysfunction (HP:0000124)2.02512080
106Bundle branch block (HP:0011710)2.01598671
107Drooling (HP:0002307)2.00464436
108Excessive salivation (HP:0003781)2.00464436
109Ankle clonus (HP:0011448)2.00231409
110Syncope (HP:0001279)2.00120159
111Absent eyebrow (HP:0002223)1.99823937
112Abnormality of calcium-phosphate metabolism (HP:0100530)1.97310574
113Thyroid carcinoma (HP:0002890)1.96666140
114Focal dystonia (HP:0004373)1.95378744
115Torticollis (HP:0000473)1.93063462
116Metabolic alkalosis (HP:0200114)1.92892688
117Abnormality of serum amino acid levels (HP:0003112)1.92654320
118Bradykinesia (HP:0002067)1.91781121
119Renal tubular acidosis (HP:0001947)1.91400120
120Pheochromocytoma (HP:0002666)1.90551192
121EEG with generalized epileptiform discharges (HP:0011198)1.88233525
122Abnormality of renin-angiotensin system (HP:0000847)1.87072762
123Rickets (HP:0002748)1.87071383
124Deep venous thrombosis (HP:0002625)1.86996566
125Abnormality of ocular smooth pursuit (HP:0000617)1.86847411
126Neuronal loss in central nervous system (HP:0002529)1.85793672
127Abnormality of the Achilles tendon (HP:0005109)1.85732576
128Barrel-shaped chest (HP:0001552)1.84279505
129Gingival bleeding (HP:0000225)1.83053682
130Genital tract atresia (HP:0001827)1.82835890
131Hyperbilirubinemia (HP:0002904)1.82109524
132Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.81595841
133Lower limb asymmetry (HP:0100559)1.80817101
134Abnormal vertebral ossification (HP:0100569)1.80125189
135Hypoglycemic seizures (HP:0002173)1.80098731
136Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.80040031
137Abnormality of endocrine pancreas physiology (HP:0012093)1.79852079
138Abnormality of the pancreatic islet cells (HP:0006476)1.79852079
139Medial flaring of the eyebrow (HP:0010747)1.79487038
140Urinary urgency (HP:0000012)1.79300048
141Abnormality of the alveolar ridges (HP:0006477)1.79182031
142Type II lissencephaly (HP:0007260)1.78905823
143Rapidly progressive (HP:0003678)1.78749950
144Hepatitis (HP:0012115)1.78712736
145Xanthomatosis (HP:0000991)1.78147006
146Female pseudohermaphroditism (HP:0010458)1.78060332
147Medulloblastoma (HP:0002885)1.76965498
148Acanthocytosis (HP:0001927)1.76825706
149Hyperparathyroidism (HP:0000843)1.76623899
150Achilles tendon contracture (HP:0001771)1.76165673
151Cerebral hemorrhage (HP:0001342)1.76082364
152Hyperinsulinemic hypoglycemia (HP:0000825)1.75971576
153Termporal pattern (HP:0011008)1.75026721
154Insidious onset (HP:0003587)1.75026721
155Epidermoid cyst (HP:0200040)1.74574358
156Hypsarrhythmia (HP:0002521)1.74422399
157Vaginal atresia (HP:0000148)1.74268689
158Psychosis (HP:0000709)1.74174334
159Impaired vibratory sensation (HP:0002495)1.74078823
160Hypokalemic alkalosis (HP:0001949)1.72628977
161Glycosuria (HP:0003076)1.72573275
162Abnormality of urine glucose concentration (HP:0011016)1.72573275
163Abnormality of the gastric mucosa (HP:0004295)1.72260603
164Absent eyelashes (HP:0000561)1.72081901
165Cystic hygroma (HP:0000476)1.71744802
166Generalized myoclonic seizures (HP:0002123)1.71694992
167Hypercortisolism (HP:0001578)1.71508195
168Sensorimotor neuropathy (HP:0007141)1.71479313
169Renal Fanconi syndrome (HP:0001994)1.69908245
170Gait ataxia (HP:0002066)1.69777423
171Abnormality of the common coagulation pathway (HP:0010990)1.69594929
172Dysostosis multiplex (HP:0000943)1.69419722
173Nephroblastoma (Wilms tumor) (HP:0002667)1.68932620
174Hyperlipoproteinemia (HP:0010980)1.68651752
175Right ventricular cardiomyopathy (HP:0011663)1.67675756
176Spastic gait (HP:0002064)1.67667224
177Hypoplastic ischia (HP:0003175)1.67240603
178Late onset (HP:0003584)1.66967085
179Polygenic inheritance (HP:0010982)1.66772601
180Abnormality of the corticospinal tract (HP:0002492)1.66740482
181Urinary bladder sphincter dysfunction (HP:0002839)1.66602110
182Lissencephaly (HP:0001339)1.66368075
183Flat acetabular roof (HP:0003180)1.65682138
184Gonadotropin excess (HP:0000837)1.65646586
185Acute hepatic failure (HP:0006554)1.65280876
186Muscular hypotonia of the trunk (HP:0008936)1.64360751
187Elevated alkaline phosphatase (HP:0003155)1.63659841

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K25.78252255
2EPHA44.14075095
3NTRK33.92910664
4AKT33.77361838
5MAP3K93.39223195
6DYRK1B3.31920773
7CASK3.02966585
8RIPK43.01594404
9MAP3K42.70113189
10MAP4K12.62049724
11CDK122.56823232
12KSR22.39497758
13DAPK22.24888832
14TXK2.24012723
15EPHA32.22917437
16MAP2K42.20621035
17MAP3K22.11593295
18MAP2K72.09196670
19CAMKK12.05403658
20MINK12.01646112
21PRKD31.90479083
22CAMKK21.86961953
23PAK61.78740504
24MAP3K121.76570246
25FRK1.68367713
26TRIB31.65909726
27RPS6KA41.64202567
28STK38L1.60381089
29NTRK11.57241764
30BCR1.49603170
31STK381.49193000
32MAPK131.48883980
33PASK1.44436538
34NEK91.43023192
35DAPK11.40486037
36RIPK11.40175341
37TAF11.39330025
38MAP3K131.38758414
39RET1.35978750
40ARAF1.35719073
41PIM21.34028514
42EEF2K1.32426403
43CDK51.30297024
44WNK41.30230178
45BMPR21.27215676
46CSNK1G21.25638191
47SRPK11.23988003
48MAP3K11.22283934
49PTK2B1.20973720
50KSR11.20562779
51CAMK1G1.17705283
52FES1.16994480
53BRAF1.15990313
54EIF2AK31.14609382
55FGFR41.12874602
56FER1.11608662
57CDK191.10394107
58PDK11.04476495
59RAF11.03792947
60BRD41.03332788
61SIK31.01738071
62MAP3K71.00835455
63PDPK10.98276277
64OXSR10.97905832
65EIF2AK10.95801641
66CDK60.95665239
67CAMK10.95636901
68GRK50.91784952
69NTRK20.91169431
70PAK30.90265101
71PRKCG0.89971176
72PRKCH0.89855784
73TAOK10.85236630
74PLK20.84356229
75CAMK2B0.83163821
76CDK30.82682339
77CAMK2A0.82604233
78EPHA20.81821658
79FGFR20.81651393
80SCYL20.81439567
81LMTK20.81230481
82PIM10.81136851
83MARK10.80168837
84TYRO30.77871432
85EPHB10.77766867
86PTK60.76308301
87CAMK1D0.75933514
88PINK10.75784250
89PKN20.74422402
90LRRK20.74411324
91SIK20.74110884
92STK110.73470091
93CDK70.73261881
94MAP2K20.72911423
95MARK20.71971223
96PIK3CA0.71402282
97INSRR0.71114910
98RPS6KB10.70605996
99GRK60.68943087
100TAOK30.67814160
101WNK10.67591638
102DYRK1A0.67250955
103SMG10.65585147
104MAP2K10.65231128
105STK390.64985561
106RPS6KB20.64083059
107CSNK1E0.63905079
108TNIK0.63289445
109DYRK30.62719928
110SGK10.62184751
111DMPK0.61105153
112YES10.60400788
113PDK40.59333146
114PDK30.59333146
115SGK30.59145384
116DYRK20.58964867
117JAK20.58724653
118SGK4940.57914977
119SGK2230.57914977
120BRSK20.57327182
121PRKCQ0.56724365
122ZAP700.55003042
123CSNK1A1L0.54724351
124HIPK20.52909878
125IRAK20.52884530
126CAMK2D0.50572235
127CLK10.50563265
128FYN0.50276344
129PTK20.49800923
130CSNK1G30.47713716
131CAMK2G0.47667647
132UHMK10.47240953
133PRKD10.46304873
134RPS6KL10.46213116
135RPS6KC10.46213116
136MATK0.44918490
137PRKCZ0.44774729
138CAMK40.44552738
139RPS6KA20.44503394
140PDGFRA0.44391905
141JAK10.43490574
142PRKD20.43018503
143TRIM280.41987043
144MAP3K60.41618237
145PRKCE0.40969894
146ERN10.40060911
147FLT30.39761243
148CDK140.39588110
149NME10.39084261
150CDK90.38940662
151SIK10.38139865
152SGK20.37950319
153TNK20.37638587
154MST1R0.36864686
155MAPK100.36376748
156FGR0.35077899
157ALK0.34395606
158MAP3K140.32543411
159EIF2AK20.32364491
160CSNK2A20.32171929
161NEK60.30807842
162PRKAA20.30714596
163FGFR30.30219668
164CDK20.29562141

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.50833277
2Long-term potentiation_Homo sapiens_hsa047202.50710500
3Pentose and glucuronate interconversions_Homo sapiens_hsa000402.46639368
4Retinol metabolism_Homo sapiens_hsa008302.40541499
5Nicotine addiction_Homo sapiens_hsa050332.31046510
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.13030641
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.11239245
8Phenylalanine metabolism_Homo sapiens_hsa003602.09600950
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.09166783
10Amphetamine addiction_Homo sapiens_hsa050312.06882474
11Circadian entrainment_Homo sapiens_hsa047132.06560031
12Glutamatergic synapse_Homo sapiens_hsa047241.96672499
13Salivary secretion_Homo sapiens_hsa049701.96178767
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.95011414
15Synaptic vesicle cycle_Homo sapiens_hsa047211.94016425
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.91693570
17GABAergic synapse_Homo sapiens_hsa047271.86517237
18Vitamin digestion and absorption_Homo sapiens_hsa049771.84920734
19Insulin secretion_Homo sapiens_hsa049111.84907897
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.83929920
21Gastric acid secretion_Homo sapiens_hsa049711.83601837
22Complement and coagulation cascades_Homo sapiens_hsa046101.83176326
23Histidine metabolism_Homo sapiens_hsa003401.81590186
24Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.81160434
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.77085871
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.77028461
27Olfactory transduction_Homo sapiens_hsa047401.76641273
28Peroxisome_Homo sapiens_hsa041461.73839214
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.73784490
30Caffeine metabolism_Homo sapiens_hsa002321.72092519
31Dopaminergic synapse_Homo sapiens_hsa047281.69923601
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.69504684
33Morphine addiction_Homo sapiens_hsa050321.69124476
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.66861388
35Starch and sucrose metabolism_Homo sapiens_hsa005001.66306543
36Renin secretion_Homo sapiens_hsa049241.64511485
37Chemical carcinogenesis_Homo sapiens_hsa052041.62342718
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.56122312
39Steroid biosynthesis_Homo sapiens_hsa001001.49717756
40Cholinergic synapse_Homo sapiens_hsa047251.46902979
41Biosynthesis of amino acids_Homo sapiens_hsa012301.40503012
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.38935804
43Bile secretion_Homo sapiens_hsa049761.27923671
44N-Glycan biosynthesis_Homo sapiens_hsa005101.26521714
45Long-term depression_Homo sapiens_hsa047301.24314310
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23873065
47Oxytocin signaling pathway_Homo sapiens_hsa049211.23105066
48Taste transduction_Homo sapiens_hsa047421.20689573
49GnRH signaling pathway_Homo sapiens_hsa049121.20465563
50Pancreatic secretion_Homo sapiens_hsa049721.18887553
51Type II diabetes mellitus_Homo sapiens_hsa049301.17707190
52Cocaine addiction_Homo sapiens_hsa050301.17158062
53Calcium signaling pathway_Homo sapiens_hsa040201.16287236
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.14716908
55Carbohydrate digestion and absorption_Homo sapiens_hsa049731.14701031
56Linoleic acid metabolism_Homo sapiens_hsa005911.13636168
57Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13416096
58Basal transcription factors_Homo sapiens_hsa030221.09895337
59cAMP signaling pathway_Homo sapiens_hsa040241.09060486
60Cysteine and methionine metabolism_Homo sapiens_hsa002701.08689220
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08528184
62Thyroid hormone synthesis_Homo sapiens_hsa049181.07941098
63Arginine biosynthesis_Homo sapiens_hsa002201.06567825
64Arginine and proline metabolism_Homo sapiens_hsa003301.06552313
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06494245
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06284966
67Estrogen signaling pathway_Homo sapiens_hsa049151.05263167
68Lysine degradation_Homo sapiens_hsa003101.03162553
69Serotonergic synapse_Homo sapiens_hsa047261.03133516
70Glioma_Homo sapiens_hsa052140.99364460
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97607196
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94155821
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94030627
74Collecting duct acid secretion_Homo sapiens_hsa049660.91045316
75Sulfur metabolism_Homo sapiens_hsa009200.89650472
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.88529741
77Tyrosine metabolism_Homo sapiens_hsa003500.88106441
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87331623
79Carbon metabolism_Homo sapiens_hsa012000.85596205
80Glucagon signaling pathway_Homo sapiens_hsa049220.85155678
81Gap junction_Homo sapiens_hsa045400.85066294
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.84413555
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83602191
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81239475
85VEGF signaling pathway_Homo sapiens_hsa043700.80462070
86Sphingolipid metabolism_Homo sapiens_hsa006000.80114714
87Melanogenesis_Homo sapiens_hsa049160.78777433
88Dorso-ventral axis formation_Homo sapiens_hsa043200.77975356
89PPAR signaling pathway_Homo sapiens_hsa033200.76901033
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.76678466
91Propanoate metabolism_Homo sapiens_hsa006400.75129918
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74457484
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71894395
94Fatty acid biosynthesis_Homo sapiens_hsa000610.71653326
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.70714600
96Fatty acid degradation_Homo sapiens_hsa000710.70582129
97Butanoate metabolism_Homo sapiens_hsa006500.70311590
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69512171
99Endometrial cancer_Homo sapiens_hsa052130.68880521
100ErbB signaling pathway_Homo sapiens_hsa040120.68531402
101Vibrio cholerae infection_Homo sapiens_hsa051100.68020031
102Choline metabolism in cancer_Homo sapiens_hsa052310.68005274
103Renin-angiotensin system_Homo sapiens_hsa046140.66883770
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66766323
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.66240681
106Glycerolipid metabolism_Homo sapiens_hsa005610.65391325
107Base excision repair_Homo sapiens_hsa034100.64255892
108Metabolic pathways_Homo sapiens_hsa011000.62681677
109Mineral absorption_Homo sapiens_hsa049780.62410140
110Selenocompound metabolism_Homo sapiens_hsa004500.62118079
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.61670323
112Fatty acid elongation_Homo sapiens_hsa000620.61434864
113Inositol phosphate metabolism_Homo sapiens_hsa005620.60305463
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60110015
115Nucleotide excision repair_Homo sapiens_hsa034200.59766212
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58069560
117Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57140955
118beta-Alanine metabolism_Homo sapiens_hsa004100.56913057
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56165453
120Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56107641
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54021812
122Fatty acid metabolism_Homo sapiens_hsa012120.53428213
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52841667
124Arachidonic acid metabolism_Homo sapiens_hsa005900.52102621
125Cardiac muscle contraction_Homo sapiens_hsa042600.49449525
126Insulin resistance_Homo sapiens_hsa049310.49099851
127Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48934450
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.48207168
129mTOR signaling pathway_Homo sapiens_hsa041500.47918580
130Fat digestion and absorption_Homo sapiens_hsa049750.47187789
131Insulin signaling pathway_Homo sapiens_hsa049100.46899073
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46740201
133Ether lipid metabolism_Homo sapiens_hsa005650.44623474
134African trypanosomiasis_Homo sapiens_hsa051430.44375883
135Rap1 signaling pathway_Homo sapiens_hsa040150.44321628
136Neurotrophin signaling pathway_Homo sapiens_hsa047220.44284309
137Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44134312
138Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43536284
139Sphingolipid signaling pathway_Homo sapiens_hsa040710.42549829
140Thyroid cancer_Homo sapiens_hsa052160.41936886
141Ras signaling pathway_Homo sapiens_hsa040140.40856447
142Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40686153
143Axon guidance_Homo sapiens_hsa043600.40305462
144Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.39763132
145Protein digestion and absorption_Homo sapiens_hsa049740.39615174
146Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39232386
147ABC transporters_Homo sapiens_hsa020100.37500268
148Prion diseases_Homo sapiens_hsa050200.37091266
149MAPK signaling pathway_Homo sapiens_hsa040100.35805569
150Pyruvate metabolism_Homo sapiens_hsa006200.35180281
151Non-small cell lung cancer_Homo sapiens_hsa052230.35132669
152AMPK signaling pathway_Homo sapiens_hsa041520.34854305
153Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34742203
154Endocytosis_Homo sapiens_hsa041440.34157419
155Tryptophan metabolism_Homo sapiens_hsa003800.33727684
156Fructose and mannose metabolism_Homo sapiens_hsa000510.31163042
157Chronic myeloid leukemia_Homo sapiens_hsa052200.30479437
158Colorectal cancer_Homo sapiens_hsa052100.30290146
159Glycerophospholipid metabolism_Homo sapiens_hsa005640.30248315
160mRNA surveillance pathway_Homo sapiens_hsa030150.29856357
161Spliceosome_Homo sapiens_hsa030400.28913534
162Pentose phosphate pathway_Homo sapiens_hsa000300.27754981
163Glutathione metabolism_Homo sapiens_hsa004800.24883015
164Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21308463

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