PLPP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.47748842
2sarcoplasmic reticulum calcium ion transport (GO:0070296)5.38578281
3actin-myosin filament sliding (GO:0033275)5.35397032
4muscle filament sliding (GO:0030049)5.35397032
5regulation of skeletal muscle contraction (GO:0014819)5.24161415
6regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.02423283
7myotube cell development (GO:0014904)5.00376100
8regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.73091669
9sarcomere organization (GO:0045214)4.64134301
10muscle hypertrophy (GO:0014896)4.61844104
11regulation of cell communication by electrical coupling (GO:0010649)4.48530942
12adult heart development (GO:0007512)4.48009091
13muscle fiber development (GO:0048747)4.44506489
14striated muscle adaptation (GO:0014888)4.39841852
15regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.36433537
16skeletal muscle contraction (GO:0003009)4.35386310
17actin-mediated cell contraction (GO:0070252)4.32909742
18muscle tissue morphogenesis (GO:0060415)4.28160672
19cardiac muscle tissue morphogenesis (GO:0055008)4.26547234
20regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.24570599
21plasma membrane repair (GO:0001778)4.21468868
22glycogen biosynthetic process (GO:0005978)4.17490449
23glucan biosynthetic process (GO:0009250)4.17490449
24cardiac muscle adaptation (GO:0014887)4.16882878
25cardiac muscle hypertrophy in response to stress (GO:0014898)4.16882878
26muscle hypertrophy in response to stress (GO:0003299)4.16882878
27myofibril assembly (GO:0030239)4.15930471
28membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.11996289
29regulation of the force of heart contraction (GO:0002026)4.09437362
30regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.09211830
31cardiac muscle cell development (GO:0055013)4.09166218
32striated muscle contraction (GO:0006941)4.07164588
33skeletal muscle tissue development (GO:0007519)4.06356101
34cardiac muscle contraction (GO:0060048)3.98978879
35regulation of membrane repolarization (GO:0060306)3.93235842
36neuronal action potential propagation (GO:0019227)3.93192071
37creatine metabolic process (GO:0006600)3.87005378
38cardiac myofibril assembly (GO:0055003)3.84834404
39cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.84589898
402-oxoglutarate metabolic process (GO:0006103)3.83536822
41negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.82011286
42cardiac cell development (GO:0055006)3.78520085
43synaptic vesicle exocytosis (GO:0016079)3.77289645
44striated muscle cell development (GO:0055002)3.75345326
45negative regulation of potassium ion transmembrane transport (GO:1901380)3.74466118
46positive regulation of myotube differentiation (GO:0010831)3.71982518
47regulation of calcium ion transmembrane transporter activity (GO:1901019)3.70636241
48regulation of calcium ion transmembrane transport (GO:1903169)3.70636241
49negative regulation of cytosolic calcium ion concentration (GO:0051481)3.66817285
50regulation of synapse structural plasticity (GO:0051823)3.62021103
51heart contraction (GO:0060047)3.62011604
52heart process (GO:0003015)3.62011604
53skeletal muscle tissue regeneration (GO:0043403)3.61257744
54polysaccharide catabolic process (GO:0000272)3.60760734
55regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.60545379
56positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.59519002
57positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.59355413
58regulation of acyl-CoA biosynthetic process (GO:0050812)3.58083048
59muscle organ development (GO:0007517)3.57662327
60muscle structure development (GO:0061061)3.56179775
61muscle cell fate commitment (GO:0042693)3.56135526
62tricarboxylic acid cycle (GO:0006099)3.54943768
63muscle adaptation (GO:0043500)3.53712773
64cell communication by electrical coupling (GO:0010644)3.52129179
65regulation of relaxation of muscle (GO:1901077)3.47098521
66regulation of actin filament-based movement (GO:1903115)3.44628769
67negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.41291173
68regulation of short-term neuronal synaptic plasticity (GO:0048172)3.40424324
69carnitine shuttle (GO:0006853)3.38613696
70response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.35840338
71regulation of cofactor metabolic process (GO:0051193)3.35836702
72regulation of coenzyme metabolic process (GO:0051196)3.35836702
73glycogen catabolic process (GO:0005980)3.33976762
74regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.33464685
75relaxation of muscle (GO:0090075)3.33375284
76gluconeogenesis (GO:0006094)3.32890396
77glycogen metabolic process (GO:0005977)3.32745126
78detection of calcium ion (GO:0005513)3.32028792
79mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.31906436
80cellular glucan metabolic process (GO:0006073)3.25280034
81glucan metabolic process (GO:0044042)3.25280034
82regulation of ATP catabolic process (GO:1903289)3.23490593
83regulation of ATPase activity (GO:0043462)3.23490593
84regulation of muscle system process (GO:0090257)3.22662112
85muscle cell development (GO:0055001)3.22079223
86membrane depolarization during action potential (GO:0086010)3.21729929
87regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.20669780
88synaptic vesicle maturation (GO:0016188)3.19794289
89regulation of sarcomere organization (GO:0060297)3.19251274
90regulation of striated muscle contraction (GO:0006942)3.18852180
91regulation of muscle contraction (GO:0006937)3.18819378
92positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.18406878
93response to inactivity (GO:0014854)3.18247043
94regulation of sequestering of triglyceride (GO:0010889)3.16736974
95ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.15547762
96positive regulation of potassium ion transmembrane transport (GO:1901381)3.13087514
97response to activity (GO:0014823)3.11767335
98glutamate secretion (GO:0014047)3.11536704
99regulation of myoblast differentiation (GO:0045661)3.10804342
100vocalization behavior (GO:0071625)3.10725052
101skeletal muscle adaptation (GO:0043501)3.09278407
102glucan catabolic process (GO:0009251)3.08558602
103regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.07954479
104striated muscle atrophy (GO:0014891)3.07940017
105actin filament-based movement (GO:0030048)3.07705571
106positive regulation of cation channel activity (GO:2001259)3.06565939
107actomyosin structure organization (GO:0031032)3.06287708
108muscle contraction (GO:0006936)3.05925531
109muscle organ morphogenesis (GO:0048644)3.05861670
110cellular potassium ion homeostasis (GO:0030007)3.05769726
111fructose metabolic process (GO:0006000)3.05629945
112cell communication involved in cardiac conduction (GO:0086065)3.05285191
113regulation of cation channel activity (GO:2001257)3.03542823
114muscle cell cellular homeostasis (GO:0046716)3.02015772
115positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.96737045
116potassium ion import (GO:0010107)2.94534493
117regulation of voltage-gated calcium channel activity (GO:1901385)2.92303979
118respiratory electron transport chain (GO:0022904)2.91089178
119sodium ion export (GO:0071436)2.88871756
120protein localization to synapse (GO:0035418)2.87545255
121ventricular cardiac muscle cell action potential (GO:0086005)2.87466625
122neuromuscular synaptic transmission (GO:0007274)2.87019146
123NADH metabolic process (GO:0006734)2.86924471
124positive regulation of synapse maturation (GO:0090129)2.86333829
125regulation of synaptic vesicle exocytosis (GO:2000300)2.85386609
126negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.84766699
127negative regulation of calcium ion transmembrane transport (GO:1903170)2.84766699
128electron transport chain (GO:0022900)2.82794075
129activation of protein kinase A activity (GO:0034199)2.81241223
130cellular polysaccharide catabolic process (GO:0044247)2.81202987
131positive regulation of ion transmembrane transporter activity (GO:0032414)2.78991654
132locomotory exploration behavior (GO:0035641)2.78212284
133muscle system process (GO:0003012)2.77970510
134positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.77205936
135mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.76845847
136G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.76783020
137cardiac muscle hypertrophy (GO:0003300)2.76724654
138neurotransmitter-gated ion channel clustering (GO:0072578)2.76381262
139cardiac muscle cell action potential (GO:0086001)2.74531045
140regulation of glutamate receptor signaling pathway (GO:1900449)2.73350087
141striated muscle hypertrophy (GO:0014897)2.73063072
142striatum development (GO:0021756)2.72423442
143response to muscle activity (GO:0014850)2.71260841
144cardiac muscle cell action potential involved in contraction (GO:0086002)2.70522966
145regulation of synaptic vesicle transport (GO:1902803)2.68457372
146skeletal muscle fiber development (GO:0048741)2.68048293
147neurotransmitter secretion (GO:0007269)2.67723782
148ATP synthesis coupled proton transport (GO:0015986)2.66502707

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.89182189
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.76535585
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.05769584
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.84382002
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.83484009
6ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.59703502
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.59051319
8GBX2_23144817_ChIP-Seq_PC3_Human2.57720897
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51730984
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.41132226
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.41132226
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.38794919
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.38665512
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.37594139
15EZH2_27294783_Chip-Seq_ESCs_Mouse2.37220597
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34133471
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.30241296
18DROSHA_22980978_ChIP-Seq_HELA_Human2.27059819
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.21979816
20REST_21632747_ChIP-Seq_MESCs_Mouse2.21870301
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.14399391
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.11088694
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.07542770
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02143007
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.94734668
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.91783495
27CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.91656258
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.89480569
29AR_21572438_ChIP-Seq_LNCaP_Human1.86053876
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75017545
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.71756709
32EP300_21415370_ChIP-Seq_HL-1_Mouse1.66807754
33ZNF274_21170338_ChIP-Seq_K562_Hela1.64769202
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.60108772
35ESR1_20079471_ChIP-ChIP_T-47D_Human1.59752964
36DNAJC2_21179169_ChIP-ChIP_NT2_Human1.50225636
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49055744
38GATA4_21415370_ChIP-Seq_HL-1_Mouse1.47499913
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43605124
40BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.41342331
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41202526
42NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40970114
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40601927
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.39758761
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39268830
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36247277
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.36158900
48CTCF_27219007_Chip-Seq_Bcells_Human1.32797760
49NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.31628259
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.29984612
51EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.27273184
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25640667
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23570588
54NFIB_24661679_ChIP-Seq_LUNG_Mouse1.22732248
55ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.21523508
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.20895893
57SMAD4_21799915_ChIP-Seq_A2780_Human1.20391011
58SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18837951
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18648592
60STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.18109246
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17140652
62TBX20_22080862_ChIP-Seq_HEART_Mouse1.16923902
63TBX20_22328084_ChIP-Seq_HEART_Mouse1.16923902
64ZNF263_19887448_ChIP-Seq_K562_Human1.16441203
65P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16086399
66RING1B_27294783_Chip-Seq_ESCs_Mouse1.15942073
67SMC3_22415368_ChIP-Seq_MEFs_Mouse1.15055965
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13145144
69NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.11110424
70ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.10387873
71PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.09520380
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.09260786
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08970690
74TAF15_26573619_Chip-Seq_HEK293_Human1.08856396
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08632115
76AR_19668381_ChIP-Seq_PC3_Human1.07726858
77EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06757921
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06708701
79ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06057188
80MYC_27129775_Chip-Seq_CORNEA_Mouse1.04691258
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04647185
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04479263
83ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04232315
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04197838
85WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03311561
86AR_25329375_ChIP-Seq_VCAP_Human1.03009150
87CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02549960
88NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02013935
89LXR_22292898_ChIP-Seq_THP-1_Human1.00423398
90VDR_22108803_ChIP-Seq_LS180_Human0.99189961
91SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98264081
92RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97429728
93EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97258578
94RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96743920
95GATA1_19941827_ChIP-Seq_MEL_Mouse0.95025616
96RAD21_21589869_ChIP-Seq_MESCs_Mouse0.93539225
97SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91744303
98TP53_20018659_ChIP-ChIP_R1E_Mouse0.91708972
99TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91393731
100SMAD3_21741376_ChIP-Seq_EPCs_Human0.91370073
101FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.90655781
102ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90059026
103SMAD4_21741376_ChIP-Seq_HESCs_Human0.89952205
104MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89229635
105PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89115193
106CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88586957
107RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.88477327
108WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88058820
109KLF4_19829295_ChIP-Seq_ESCs_Human0.87600334
110SMAD3_21741376_ChIP-Seq_HESCs_Human0.86859540
111SA1_27219007_Chip-Seq_Bcells_Human0.86579110
112MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.86370000
113RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.85858617
114CTCF_21964334_ChIP-Seq_BJAB-B_Human0.85798358
115OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.85628443
116P300_19829295_ChIP-Seq_ESCs_Human0.85515916
117BMI1_23680149_ChIP-Seq_NPCS_Mouse0.84603553
118KDM2B_26808549_Chip-Seq_DND41_Human0.84425760
119TP53_23651856_ChIP-Seq_MEFs_Mouse0.84380963
120KDM2B_26808549_Chip-Seq_K562_Human0.84209534
121OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83741612
122DPY_21335234_ChIP-Seq_ESCs_Mouse0.83599931
123BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83145814
124TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.82591984
125ESR2_21235772_ChIP-Seq_MCF-7_Human0.81857863
126FOXH1_21741376_ChIP-Seq_ESCs_Human0.81615310
127GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81572791
128UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.81502246
129STAT3_23295773_ChIP-Seq_U87_Human0.81429726
130MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.81353249
131BCAT_22108803_ChIP-Seq_LS180_Human0.81205923
132SPI1_20517297_ChIP-Seq_HL60_Human0.80943600
133SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80436215
134CLOCK_20551151_ChIP-Seq_293T_Human0.79817130
135CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.79179712
136OCT4_20526341_ChIP-Seq_ESCs_Human0.78826838
137SMAD3_21741376_ChIP-Seq_ESCs_Human0.77887624
138TET1_21490601_ChIP-Seq_MESCs_Mouse0.77787155
139TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77736313
140NR3C1_21868756_ChIP-Seq_MCF10A_Human0.77291685
141SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77214974
142KDM2B_26808549_Chip-Seq_SUP-B15_Human0.74931190
143OCT4_19829295_ChIP-Seq_ESCs_Human0.74157138

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000751_myopathy4.70439798
2MP0002837_dystrophic_cardiac_calcinosis4.68138698
3MP0003646_muscle_fatigue4.64022284
4MP0004145_abnormal_muscle_electrophysio4.41507966
5MP0000749_muscle_degeneration3.89147484
6MP0004036_abnormal_muscle_relaxation3.52449846
7MP0004859_abnormal_synaptic_plasticity3.23709858
8MP0004084_abnormal_cardiac_muscle2.99849627
9MP0004215_abnormal_myocardial_fiber2.81402710
10MP0005451_abnormal_body_composition2.73657700
11MP0004270_analgesia2.63202428
12MP0002106_abnormal_muscle_physiology2.61504506
13MP0000747_muscle_weakness2.57937014
14MP0004233_abnormal_muscle_weight2.43195708
15MP0003880_abnormal_central_pattern2.41560147
16MP0005620_abnormal_muscle_contractility2.35049238
17MP0003635_abnormal_synaptic_transmissio2.22927958
18MP0004087_abnormal_muscle_fiber2.22676172
19MP0005369_muscle_phenotype2.17201462
20MP0002269_muscular_atrophy2.15957815
21MP0000759_abnormal_skeletal_muscle2.15256060
22MP0000750_abnormal_muscle_regeneration2.02596948
23MP0005330_cardiomyopathy2.01284294
24MP0004130_abnormal_muscle_cell2.00756735
25MP0000733_abnormal_muscle_development1.88292104
26MP0003137_abnormal_impulse_conducting1.81052841
27MP0002064_seizures1.80784143
28MP0002822_catalepsy1.78730878
29MP0009745_abnormal_behavioral_response1.78331265
30MP0002972_abnormal_cardiac_muscle1.77865657
31MP0009046_muscle_twitch1.73566129
32MP0002332_abnormal_exercise_endurance1.72843111
33MP0002063_abnormal_learning/memory/cond1.68622446
34MP0002272_abnormal_nervous_system1.66540357
35MP0004484_altered_response_of1.57954134
36MP0002734_abnormal_mechanical_nocicepti1.56004309
37MP0004085_abnormal_heartbeat1.51861736
38MP0008569_lethality_at_weaning1.51469857
39MP0008775_abnormal_heart_ventricle1.44842429
40MP0001968_abnormal_touch/_nociception1.44362453
41MP0002909_abnormal_adrenal_gland1.42671763
42MP0006036_abnormal_mitochondrial_physio1.41089556
43MP0005670_abnormal_white_adipose1.41001500
44MP0002572_abnormal_emotion/affect_behav1.38775829
45MP0001486_abnormal_startle_reflex1.33834015
46MP0001529_abnormal_vocalization1.33429013
47MP0003329_amyloid_beta_deposits1.31877228
48MP0002067_abnormal_sensory_capabilities1.31068594
49MP0000013_abnormal_adipose_tissue1.29113011
50MP0005385_cardiovascular_system_phenoty1.25594711
51MP0001544_abnormal_cardiovascular_syste1.25594711
52MP0001440_abnormal_grooming_behavior1.24988036
53MP0009780_abnormal_chondrocyte_physiolo1.20377438
54MP0005386_behavior/neurological_phenoty1.17432044
55MP0004924_abnormal_behavior1.17432044
56MP0006276_abnormal_autonomic_nervous1.16241074
57MP0005551_abnormal_eye_electrophysiolog1.14268273
58MP0002736_abnormal_nociception_after1.13820310
59MP0005423_abnormal_somatic_nervous1.13248103
60MP0004142_abnormal_muscle_tone1.11712223
61MP0004858_abnormal_nervous_system1.07421584
62MP0002735_abnormal_chemical_nociception1.05791857
63MP0010630_abnormal_cardiac_muscle1.04346760
64MP0001984_abnormal_olfaction1.03144915
65MP0006138_congestive_heart_failure1.02988808
66MP0001970_abnormal_pain_threshold1.01367604
67MP0005666_abnormal_adipose_tissue1.01285843
68MP0002108_abnormal_muscle_morphology1.00763528
69MP0002184_abnormal_innervation1.00447188
70MP0003221_abnormal_cardiomyocyte_apopto1.00199673
71MP0002971_abnormal_brown_adipose0.99273529
72MP0001501_abnormal_sleep_pattern0.98726771
73MP0001502_abnormal_circadian_rhythm0.98292704
74MP0006035_abnormal_mitochondrial_morpho0.97680331
75MP0002733_abnormal_thermal_nociception0.97271500
76MP0002090_abnormal_vision0.97163138
77MP0002234_abnormal_pharynx_morphology0.95986599
78MP0002066_abnormal_motor_capabilities/c0.94381944
79MP0000955_abnormal_spinal_cord0.92367934
80MP0006072_abnormal_retinal_apoptosis0.91569582
81MP0001905_abnormal_dopamine_level0.91163785
82MP0003633_abnormal_nervous_system0.91051390
83MP0005375_adipose_tissue_phenotype0.90348295
84MP0005646_abnormal_pituitary_gland0.88931995
85MP0004043_abnormal_pH_regulation0.87706365
86MP0004811_abnormal_neuron_physiology0.85369665
87MP0004185_abnormal_adipocyte_glucose0.84790866
88MP0002557_abnormal_social/conspecific_i0.84193570
89MP0001661_extended_life_span0.83849375
90MP0003828_pulmonary_edema0.83843435
91MP0002882_abnormal_neuron_morphology0.83662270
92MP0002127_abnormal_cardiovascular_syste0.83159327
93MP0005535_abnormal_body_temperature0.83142808
94MP0004510_myositis0.80251814
95MP0003879_abnormal_hair_cell0.79772229
96MP0002229_neurodegeneration0.79409685
97MP0003950_abnormal_plasma_membrane0.79035585
98MP0005266_abnormal_metabolism0.77676382
99MP0000003_abnormal_adipose_tissue0.75345501
100MP0000230_abnormal_systemic_arterial0.72472305
101MP0001299_abnormal_eye_distance/0.71619974
102MP0003631_nervous_system_phenotype0.70844154
103MP0000266_abnormal_heart_morphology0.67981120
104MP0000778_abnormal_nervous_system0.66412597
105MP0005623_abnormal_meninges_morphology0.64664306
106MP0003634_abnormal_glial_cell0.61870053
107MP0000920_abnormal_myelination0.61759663
108MP0005083_abnormal_biliary_tract0.61544409
109MP0004147_increased_porphyrin_level0.61083413
110MP0005165_increased_susceptibility_to0.60962034
111MP0004885_abnormal_endolymph0.59596769
112MP0002638_abnormal_pupillary_reflex0.58013226
113MP0003045_fibrosis0.53806519
114MP0002128_abnormal_blood_circulation0.49236518
115MP0005167_abnormal_blood-brain_barrier0.45239596
116MP0002078_abnormal_glucose_homeostasis0.44104179
117MP0003279_aneurysm0.42333802
118MP0005187_abnormal_penis_morphology0.41454197
119MP0004134_abnormal_chest_morphology0.39413998
120MP0010030_abnormal_orbit_morphology0.35229733
121MP0000762_abnormal_tongue_morphology0.34627911
122MP0005584_abnormal_enzyme/coenzyme_acti0.32607790
123MP0008874_decreased_physiological_sensi0.32007953
124MP0003705_abnormal_hypodermis_morpholog0.31434717
125MP0005334_abnormal_fat_pad0.31160578
126MP0005452_abnormal_adipose_tissue0.30738215
127MP0001346_abnormal_lacrimal_gland0.30612920
128MP0002114_abnormal_axial_skeleton0.29977863
129MP0000343_altered_response_to0.29864289
130MP0009250_abnormal_appendicular_skeleto0.29671422
131MP0003948_abnormal_gas_homeostasis0.29528136
132MP0010368_abnormal_lymphatic_system0.28251816
133MP0005166_decreased_susceptibility_to0.26824616
134MP0000372_irregular_coat_pigmentation0.26130824

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)7.31401988
2Exercise-induced muscle cramps (HP:0003710)6.18709379
3Muscle hypertrophy of the lower extremities (HP:0008968)5.96753587
4Calf muscle hypertrophy (HP:0008981)5.62760103
5Muscle fiber inclusion bodies (HP:0100299)5.00306326
6Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.85964772
7Sudden death (HP:0001699)4.64791269
8Abnormality of the calf musculature (HP:0001430)4.40161955
9Nemaline bodies (HP:0003798)4.37007846
10Muscle fiber splitting (HP:0003555)4.34579240
11Myoglobinuria (HP:0002913)4.31954409
12Difficulty running (HP:0009046)4.05997968
13EMG: myopathic abnormalities (HP:0003458)4.03753929
14Myotonia (HP:0002486)4.02180509
15Distal lower limb muscle weakness (HP:0009053)4.00076725
16Hyporeflexia of lower limbs (HP:0002600)3.98600584
17Type 1 muscle fiber predominance (HP:0003803)3.69400424
18Myopathic facies (HP:0002058)3.67382419
19Distal arthrogryposis (HP:0005684)3.58458924
20Muscle stiffness (HP:0003552)3.57660868
21Frequent falls (HP:0002359)3.34733398
22Round ear (HP:0100830)3.29969073
23Focal motor seizures (HP:0011153)3.24510335
24Subaortic stenosis (HP:0001682)3.12941664
25Abnormality of the left ventricular outflow tract (HP:0011103)3.12941664
26Prolonged QT interval (HP:0001657)3.09381216
27Atrial fibrillation (HP:0005110)3.08627209
28Rhabdomyolysis (HP:0003201)3.06645934
29Increased variability in muscle fiber diameter (HP:0003557)3.06350972
30Asymmetric septal hypertrophy (HP:0001670)3.02311159
31Abnormality of skeletal muscle fiber size (HP:0012084)3.01750001
32Primary atrial arrhythmia (HP:0001692)2.92073337
33Mildly elevated creatine phosphokinase (HP:0008180)2.91711931
34Generalized muscle weakness (HP:0003324)2.88300333
35Ventricular tachycardia (HP:0004756)2.84842994
36Difficulty climbing stairs (HP:0003551)2.82927389
37Supraventricular tachycardia (HP:0004755)2.79292800
38Syncope (HP:0001279)2.76229261
39Distal lower limb amyotrophy (HP:0008944)2.75367948
40Bundle branch block (HP:0011710)2.74747790
41Supraventricular arrhythmia (HP:0005115)2.71463530
42Central scotoma (HP:0000603)2.70904517
43Myokymia (HP:0002411)2.70862588
44Increased connective tissue (HP:0009025)2.69301156
45Visual hallucinations (HP:0002367)2.67832948
46Abnormal mitochondria in muscle tissue (HP:0008316)2.65958702
47Calcaneovalgus deformity (HP:0001848)2.64246139
48Bulbar palsy (HP:0001283)2.60522614
49Acute necrotizing encephalopathy (HP:0006965)2.54512904
50Ventricular fibrillation (HP:0001663)2.53179937
51Neck muscle weakness (HP:0000467)2.53019546
52Pheochromocytoma (HP:0002666)2.51990454
53Hepatocellular necrosis (HP:0001404)2.50409195
54Scapular winging (HP:0003691)2.49147413
55Weak cry (HP:0001612)2.48756240
56Palpitations (HP:0001962)2.45768385
57Abnormal EKG (HP:0003115)2.45499050
58Rimmed vacuoles (HP:0003805)2.41366710
59Ulnar deviation of the wrist (HP:0003049)2.40511649
60Abnormality of the foot musculature (HP:0001436)2.39046788
61Gowers sign (HP:0003391)2.38774747
62Slender build (HP:0001533)2.37696549
63Deformed tarsal bones (HP:0008119)2.33577953
64Neuroendocrine neoplasm (HP:0100634)2.33371619
65Lipoatrophy (HP:0100578)2.31878242
66Ventricular arrhythmia (HP:0004308)2.31514172
67Atonic seizures (HP:0010819)2.31356320
68Left ventricular hypertrophy (HP:0001712)2.31160967
69Mitochondrial inheritance (HP:0001427)2.30737173
70Spinal rigidity (HP:0003306)2.30148715
71Centrally nucleated skeletal muscle fibers (HP:0003687)2.29196904
72Shoulder girdle muscle weakness (HP:0003547)2.29020747
73Focal seizures (HP:0007359)2.28657274
74Hepatic necrosis (HP:0002605)2.27900683
75Areflexia of lower limbs (HP:0002522)2.25810091
76Hip contracture (HP:0003273)2.24197107
77Limb-girdle muscle atrophy (HP:0003797)2.23860873
78Epileptic encephalopathy (HP:0200134)2.20657671
79Lower limb amyotrophy (HP:0007210)2.20476130
80Progressive muscle weakness (HP:0003323)2.20363749
81Muscular dystrophy (HP:0003560)2.20184688
82Absent phalangeal crease (HP:0006109)2.19063226
83Foot dorsiflexor weakness (HP:0009027)2.18414622
84Dilated cardiomyopathy (HP:0001644)2.16165706
85Increased intramyocellular lipid droplets (HP:0012240)2.13903606
86Abnormality of the calcaneus (HP:0008364)2.13251146
87Ragged-red muscle fibers (HP:0003200)2.13163861
88Heart block (HP:0012722)2.11343272
89Progressive macrocephaly (HP:0004481)2.10884282
90Waddling gait (HP:0002515)2.10190537
91Proximal amyotrophy (HP:0007126)2.09656263
92Generalized tonic-clonic seizures (HP:0002069)2.08888479
93Abnormality of the hip-girdle musculature (HP:0001445)2.07449994
94Abnormality of the musculature of the pelvis (HP:0001469)2.07449994
95Absence seizures (HP:0002121)2.06935944
96Ketoacidosis (HP:0001993)2.06209340
97Acute encephalopathy (HP:0006846)2.04012094
98Abnormality of the shoulder girdle musculature (HP:0001435)2.03362810
99Increased muscle lipid content (HP:0009058)2.02735910
100Increased CSF lactate (HP:0002490)2.02186997
101EMG: neuropathic changes (HP:0003445)2.00308171
102Exercise intolerance (HP:0003546)1.96801866
103Dialeptic seizures (HP:0011146)1.96195303
104Malignant hyperthermia (HP:0002047)1.95781323
105Ankle clonus (HP:0011448)1.95491799
106Hyperkalemia (HP:0002153)1.94827679
107Abnormal atrioventricular conduction (HP:0005150)1.92585195
108Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91192626
109Abnormality of alanine metabolism (HP:0010916)1.91192626
110Hyperalaninemia (HP:0003348)1.91192626
111Respiratory insufficiency due to muscle weakness (HP:0002747)1.91079403
112Fetal akinesia sequence (HP:0001989)1.90717320
113Depression (HP:0000716)1.90213843
114Pelvic girdle muscle weakness (HP:0003749)1.90055829
115Anxiety (HP:0000739)1.89597723
116Poor eye contact (HP:0000817)1.87691093
117Abnormality of the neuromuscular junction (HP:0003398)1.83377886
118Fatigable weakness (HP:0003473)1.83377886
119Large for gestational age (HP:0001520)1.82776783
120Abnormal finger flexion creases (HP:0006143)1.82201362
121Atrioventricular block (HP:0001678)1.81825554
122Rapidly progressive (HP:0003678)1.80070283
123Dysmetric saccades (HP:0000641)1.78771053
124Limb-girdle muscle weakness (HP:0003325)1.78604925
125Steppage gait (HP:0003376)1.58283893
126Limited hip movement (HP:0008800)1.55653409
127Nonprogressive disorder (HP:0003680)1.55412739
128Metatarsus adductus (HP:0001840)1.54805483
129Popliteal pterygium (HP:0009756)1.53908361
130Facial diplegia (HP:0001349)1.51759817
131Type 2 muscle fiber atrophy (HP:0003554)1.49948793

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PHKG14.66096854
2PHKG24.66096854
3OBSCN3.81720197
4TTN3.63501504
5EPHA43.01220793
6NME12.41007779
7LMTK22.23257728
8MAP3K42.22588654
9MUSK2.22055074
10BCKDK2.12069318
11MAP3K92.08098686
12NTRK31.97182617
13PDK31.94289372
14PDK41.94289372
15MAP2K41.86602864
16PAK61.76535027
17PINK11.76066836
18NEK11.67881587
19KSR21.62905359
20MINK11.58975362
21ARAF1.55983391
22PRKD31.48514138
23MAP3K71.46777663
24MAPKAPK31.43196424
25MAP2K71.42360881
26PIK3CG1.40082379
27PDK21.32730140
28PIK3CA1.31286868
29PRPF4B1.31050812
30MAPK121.27251908
31MARK11.25806983
32STK381.23613305
33LIMK11.21336680
34CDK191.19422363
35DMPK1.16895764
36MYLK1.13844174
37CAMK2D1.10425170
38DAPK21.08371101
39TRPM71.08033942
40MAP2K60.98965568
41NTRK10.97830877
42GRK70.96277333
43CAMK2A0.95562646
44PAK30.94910274
45TNIK0.93507540
46CDK50.88298412
47MAP3K130.87740595
48NTRK20.86148284
49CAMKK10.85585901
50PTK2B0.82696992
51CAMK40.81389151
52INSRR0.80824284
53KSR10.80800540
54GRK50.80604869
55RIPK10.80308632
56DYRK1B0.79322807
57CAMK2G0.77348192
58CAMKK20.76078284
59TIE10.75298190
60EEF2K0.74621300
61MAP3K120.74404060
62CAMK10.73903347
63PRKAA20.73492326
64TAOK20.72428051
65ROCK20.68347308
66UHMK10.67501000
67MAPK130.67090161
68TRIB30.66533112
69PRKCG0.65775256
70SGK2230.64689105
71SGK4940.64689105
72CASK0.64589211
73PKN10.64298563
74MAP3K60.64259553
75AKT20.63471343
76NEK90.63396486
77MAPK70.62579892
78WNK30.61515071
79LATS20.61054046
80MOS0.60960886
81MAP2K30.60887513
82PRKAA10.58835087
83MAPK40.58164558
84CAMK2B0.57356636
85PDPK10.57225594
86PRKCH0.56290256
87CDK140.55693281
88PRKD10.53284398
89PRKACB0.51831195
90RET0.51523970
91RAF10.51348769
92MAP3K10.50545751
93CDK150.50369385
94CDK180.50232156
95PRKCE0.49772378
96MAP2K10.49608612
97WNK40.48868406
98ROCK10.47980087
99PDK10.47896412
100DYRK1A0.47022615
101PRKACA0.46633967
102CCNB10.46281480
103DAPK30.46099943
104ERBB30.45911665
105OXSR10.45892921
106WNK10.45674435
107CDK11A0.44012737
108PLK20.42951513
109SGK30.42280580
110ICK0.41305987
111DAPK10.41132676
112RPS6KA30.39999829
113PKN20.39485813
114SGK10.37825728
115PRKG10.37323336
116MARK20.37057019
117RIPK40.35902227
118MAP3K110.33967425
119SGK20.33412165
120BRAF0.31162969
121MAPK110.31115486
122MAPK100.29345243
123RPS6KC10.27988643
124RPS6KL10.27988643
125PRKACG0.22403898
126RPS6KA60.20834200
127MAP3K50.20376092
128STK110.19824530
129TGFBR20.17963927
130RPS6KB10.17095881
131RPS6KA10.16790397
132TBK10.15527306
133SIK10.15169787
134EPHB10.12666477
135CDC42BPA0.12421917
136RPS6KA20.11827258
137TESK10.09954434

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042603.24733367
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.15736127
3Oxidative phosphorylation_Homo sapiens_hsa001902.56092160
4Parkinsons disease_Homo sapiens_hsa050122.38842659
5Dilated cardiomyopathy_Homo sapiens_hsa054142.36124583
6Synaptic vesicle cycle_Homo sapiens_hsa047212.25741894
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.19964276
8Nicotine addiction_Homo sapiens_hsa050332.18161003
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.09693035
10Alzheimers disease_Homo sapiens_hsa050102.08968770
11GABAergic synapse_Homo sapiens_hsa047272.07864507
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.03092765
13Circadian entrainment_Homo sapiens_hsa047131.99897233
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.97154404
15Insulin secretion_Homo sapiens_hsa049111.84385703
16Olfactory transduction_Homo sapiens_hsa047401.75532681
17Calcium signaling pathway_Homo sapiens_hsa040201.73588431
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.72885659
19Morphine addiction_Homo sapiens_hsa050321.72745977
20Oxytocin signaling pathway_Homo sapiens_hsa049211.68901766
21Arginine biosynthesis_Homo sapiens_hsa002201.63901008
22Glutamatergic synapse_Homo sapiens_hsa047241.61538602
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.59095945
24Pentose phosphate pathway_Homo sapiens_hsa000301.53912213
25Salivary secretion_Homo sapiens_hsa049701.51044126
26Long-term potentiation_Homo sapiens_hsa047201.50819298
27Renin secretion_Homo sapiens_hsa049241.50172737
28Gastric acid secretion_Homo sapiens_hsa049711.46547065
29Propanoate metabolism_Homo sapiens_hsa006401.43310581
30Cholinergic synapse_Homo sapiens_hsa047251.42281232
31Dopaminergic synapse_Homo sapiens_hsa047281.41220524
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.38755284
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.38639936
34Amphetamine addiction_Homo sapiens_hsa050311.38178395
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.38069099
36Huntingtons disease_Homo sapiens_hsa050161.34338304
37Collecting duct acid secretion_Homo sapiens_hsa049661.31438473
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.29786593
39Taste transduction_Homo sapiens_hsa047421.26790674
40Serotonergic synapse_Homo sapiens_hsa047261.24751481
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.22936359
42Pancreatic secretion_Homo sapiens_hsa049721.21762399
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20064552
44Carbon metabolism_Homo sapiens_hsa012001.18007370
45Glucagon signaling pathway_Homo sapiens_hsa049221.17334783
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.14765292
47Pyruvate metabolism_Homo sapiens_hsa006201.10811587
48GnRH signaling pathway_Homo sapiens_hsa049121.10662253
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07659937
50Gap junction_Homo sapiens_hsa045401.06621813
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05073152
52Circadian rhythm_Homo sapiens_hsa047101.04869276
53Long-term depression_Homo sapiens_hsa047300.96958971
54Cocaine addiction_Homo sapiens_hsa050300.96232920
55Phenylalanine metabolism_Homo sapiens_hsa003600.94423484
56cAMP signaling pathway_Homo sapiens_hsa040240.91269503
57Type II diabetes mellitus_Homo sapiens_hsa049300.87570993
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87352975
59Butanoate metabolism_Homo sapiens_hsa006500.86990604
60Insulin signaling pathway_Homo sapiens_hsa049100.86292183
61Fructose and mannose metabolism_Homo sapiens_hsa000510.85113326
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84860416
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84287094
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81321025
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80398442
66Vibrio cholerae infection_Homo sapiens_hsa051100.78980939
67Fatty acid degradation_Homo sapiens_hsa000710.76290372
68Fatty acid metabolism_Homo sapiens_hsa012120.74757232
69Biosynthesis of amino acids_Homo sapiens_hsa012300.73157914
70Focal adhesion_Homo sapiens_hsa045100.67604238
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66517719
72Melanogenesis_Homo sapiens_hsa049160.64552155
73Fatty acid elongation_Homo sapiens_hsa000620.62890220
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.61981508
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60962013
76Starch and sucrose metabolism_Homo sapiens_hsa005000.60784251
77Viral myocarditis_Homo sapiens_hsa054160.59996233
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59635564
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58377702
80PPAR signaling pathway_Homo sapiens_hsa033200.57835648
81Nitrogen metabolism_Homo sapiens_hsa009100.57766114
82Phototransduction_Homo sapiens_hsa047440.55285890
83AMPK signaling pathway_Homo sapiens_hsa041520.55230100
84Estrogen signaling pathway_Homo sapiens_hsa049150.55214861
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55011018
86Insulin resistance_Homo sapiens_hsa049310.54367536
87Galactose metabolism_Homo sapiens_hsa000520.51681610
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.49062449
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48925051
90beta-Alanine metabolism_Homo sapiens_hsa004100.46483221
91Ovarian steroidogenesis_Homo sapiens_hsa049130.44839118
92VEGF signaling pathway_Homo sapiens_hsa043700.44065811
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43969441
94MAPK signaling pathway_Homo sapiens_hsa040100.41327941
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41096051
96Axon guidance_Homo sapiens_hsa043600.39186509
97FoxO signaling pathway_Homo sapiens_hsa040680.39035412
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38120158
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.38067109
100Renal cell carcinoma_Homo sapiens_hsa052110.37225462
101Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36847326
102Platelet activation_Homo sapiens_hsa046110.36727965
103ErbB signaling pathway_Homo sapiens_hsa040120.36286504
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33936002
105Glioma_Homo sapiens_hsa052140.32876237
106Tight junction_Homo sapiens_hsa045300.31852674
107ECM-receptor interaction_Homo sapiens_hsa045120.31508234
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31156960
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30814766
110Fatty acid biosynthesis_Homo sapiens_hsa000610.30684659
111Oocyte meiosis_Homo sapiens_hsa041140.30413877
112HIF-1 signaling pathway_Homo sapiens_hsa040660.30303761
113Arginine and proline metabolism_Homo sapiens_hsa003300.29435831
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29351540
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29202359
116Regulation of autophagy_Homo sapiens_hsa041400.29049745
117Tryptophan metabolism_Homo sapiens_hsa003800.27782101
118Bile secretion_Homo sapiens_hsa049760.24892875
119Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24642753
120Tyrosine metabolism_Homo sapiens_hsa003500.23250130
121mTOR signaling pathway_Homo sapiens_hsa041500.21217744
122Peroxisome_Homo sapiens_hsa041460.21150758
123Amoebiasis_Homo sapiens_hsa051460.20835676

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