

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 5.47748842 |
| 2 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 5.38578281 |
| 3 | actin-myosin filament sliding (GO:0033275) | 5.35397032 |
| 4 | muscle filament sliding (GO:0030049) | 5.35397032 |
| 5 | regulation of skeletal muscle contraction (GO:0014819) | 5.24161415 |
| 6 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 5.02423283 |
| 7 | myotube cell development (GO:0014904) | 5.00376100 |
| 8 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 4.73091669 |
| 9 | sarcomere organization (GO:0045214) | 4.64134301 |
| 10 | muscle hypertrophy (GO:0014896) | 4.61844104 |
| 11 | regulation of cell communication by electrical coupling (GO:0010649) | 4.48530942 |
| 12 | adult heart development (GO:0007512) | 4.48009091 |
| 13 | muscle fiber development (GO:0048747) | 4.44506489 |
| 14 | striated muscle adaptation (GO:0014888) | 4.39841852 |
| 15 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 4.36433537 |
| 16 | skeletal muscle contraction (GO:0003009) | 4.35386310 |
| 17 | actin-mediated cell contraction (GO:0070252) | 4.32909742 |
| 18 | muscle tissue morphogenesis (GO:0060415) | 4.28160672 |
| 19 | cardiac muscle tissue morphogenesis (GO:0055008) | 4.26547234 |
| 20 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 4.24570599 |
| 21 | plasma membrane repair (GO:0001778) | 4.21468868 |
| 22 | glycogen biosynthetic process (GO:0005978) | 4.17490449 |
| 23 | glucan biosynthetic process (GO:0009250) | 4.17490449 |
| 24 | cardiac muscle adaptation (GO:0014887) | 4.16882878 |
| 25 | cardiac muscle hypertrophy in response to stress (GO:0014898) | 4.16882878 |
| 26 | muscle hypertrophy in response to stress (GO:0003299) | 4.16882878 |
| 27 | myofibril assembly (GO:0030239) | 4.15930471 |
| 28 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 4.11996289 |
| 29 | regulation of the force of heart contraction (GO:0002026) | 4.09437362 |
| 30 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 4.09211830 |
| 31 | cardiac muscle cell development (GO:0055013) | 4.09166218 |
| 32 | striated muscle contraction (GO:0006941) | 4.07164588 |
| 33 | skeletal muscle tissue development (GO:0007519) | 4.06356101 |
| 34 | cardiac muscle contraction (GO:0060048) | 3.98978879 |
| 35 | regulation of membrane repolarization (GO:0060306) | 3.93235842 |
| 36 | neuronal action potential propagation (GO:0019227) | 3.93192071 |
| 37 | creatine metabolic process (GO:0006600) | 3.87005378 |
| 38 | cardiac myofibril assembly (GO:0055003) | 3.84834404 |
| 39 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.84589898 |
| 40 | 2-oxoglutarate metabolic process (GO:0006103) | 3.83536822 |
| 41 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 3.82011286 |
| 42 | cardiac cell development (GO:0055006) | 3.78520085 |
| 43 | synaptic vesicle exocytosis (GO:0016079) | 3.77289645 |
| 44 | striated muscle cell development (GO:0055002) | 3.75345326 |
| 45 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 3.74466118 |
| 46 | positive regulation of myotube differentiation (GO:0010831) | 3.71982518 |
| 47 | regulation of calcium ion transmembrane transporter activity (GO:1901019) | 3.70636241 |
| 48 | regulation of calcium ion transmembrane transport (GO:1903169) | 3.70636241 |
| 49 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 3.66817285 |
| 50 | regulation of synapse structural plasticity (GO:0051823) | 3.62021103 |
| 51 | heart contraction (GO:0060047) | 3.62011604 |
| 52 | heart process (GO:0003015) | 3.62011604 |
| 53 | skeletal muscle tissue regeneration (GO:0043403) | 3.61257744 |
| 54 | polysaccharide catabolic process (GO:0000272) | 3.60760734 |
| 55 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 3.60545379 |
| 56 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.59519002 |
| 57 | positive regulation of calcium ion transmembrane transporter activity (GO:1901021) | 3.59355413 |
| 58 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 3.58083048 |
| 59 | muscle organ development (GO:0007517) | 3.57662327 |
| 60 | muscle structure development (GO:0061061) | 3.56179775 |
| 61 | muscle cell fate commitment (GO:0042693) | 3.56135526 |
| 62 | tricarboxylic acid cycle (GO:0006099) | 3.54943768 |
| 63 | muscle adaptation (GO:0043500) | 3.53712773 |
| 64 | cell communication by electrical coupling (GO:0010644) | 3.52129179 |
| 65 | regulation of relaxation of muscle (GO:1901077) | 3.47098521 |
| 66 | regulation of actin filament-based movement (GO:1903115) | 3.44628769 |
| 67 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 3.41291173 |
| 68 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 3.40424324 |
| 69 | carnitine shuttle (GO:0006853) | 3.38613696 |
| 70 | response to stimulus involved in regulation of muscle adaptation (GO:0014874) | 3.35840338 |
| 71 | regulation of cofactor metabolic process (GO:0051193) | 3.35836702 |
| 72 | regulation of coenzyme metabolic process (GO:0051196) | 3.35836702 |
| 73 | glycogen catabolic process (GO:0005980) | 3.33976762 |
| 74 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.33464685 |
| 75 | relaxation of muscle (GO:0090075) | 3.33375284 |
| 76 | gluconeogenesis (GO:0006094) | 3.32890396 |
| 77 | glycogen metabolic process (GO:0005977) | 3.32745126 |
| 78 | detection of calcium ion (GO:0005513) | 3.32028792 |
| 79 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.31906436 |
| 80 | cellular glucan metabolic process (GO:0006073) | 3.25280034 |
| 81 | glucan metabolic process (GO:0044042) | 3.25280034 |
| 82 | regulation of ATP catabolic process (GO:1903289) | 3.23490593 |
| 83 | regulation of ATPase activity (GO:0043462) | 3.23490593 |
| 84 | regulation of muscle system process (GO:0090257) | 3.22662112 |
| 85 | muscle cell development (GO:0055001) | 3.22079223 |
| 86 | membrane depolarization during action potential (GO:0086010) | 3.21729929 |
| 87 | regulation of calcineurin-NFAT signaling cascade (GO:0070884) | 3.20669780 |
| 88 | synaptic vesicle maturation (GO:0016188) | 3.19794289 |
| 89 | regulation of sarcomere organization (GO:0060297) | 3.19251274 |
| 90 | regulation of striated muscle contraction (GO:0006942) | 3.18852180 |
| 91 | regulation of muscle contraction (GO:0006937) | 3.18819378 |
| 92 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 3.18406878 |
| 93 | response to inactivity (GO:0014854) | 3.18247043 |
| 94 | regulation of sequestering of triglyceride (GO:0010889) | 3.16736974 |
| 95 | ventricular cardiac muscle tissue morphogenesis (GO:0055010) | 3.15547762 |
| 96 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 3.13087514 |
| 97 | response to activity (GO:0014823) | 3.11767335 |
| 98 | glutamate secretion (GO:0014047) | 3.11536704 |
| 99 | regulation of myoblast differentiation (GO:0045661) | 3.10804342 |
| 100 | vocalization behavior (GO:0071625) | 3.10725052 |
| 101 | skeletal muscle adaptation (GO:0043501) | 3.09278407 |
| 102 | glucan catabolic process (GO:0009251) | 3.08558602 |
| 103 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 3.07954479 |
| 104 | striated muscle atrophy (GO:0014891) | 3.07940017 |
| 105 | actin filament-based movement (GO:0030048) | 3.07705571 |
| 106 | positive regulation of cation channel activity (GO:2001259) | 3.06565939 |
| 107 | actomyosin structure organization (GO:0031032) | 3.06287708 |
| 108 | muscle contraction (GO:0006936) | 3.05925531 |
| 109 | muscle organ morphogenesis (GO:0048644) | 3.05861670 |
| 110 | cellular potassium ion homeostasis (GO:0030007) | 3.05769726 |
| 111 | fructose metabolic process (GO:0006000) | 3.05629945 |
| 112 | cell communication involved in cardiac conduction (GO:0086065) | 3.05285191 |
| 113 | regulation of cation channel activity (GO:2001257) | 3.03542823 |
| 114 | muscle cell cellular homeostasis (GO:0046716) | 3.02015772 |
| 115 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 2.96737045 |
| 116 | potassium ion import (GO:0010107) | 2.94534493 |
| 117 | regulation of voltage-gated calcium channel activity (GO:1901385) | 2.92303979 |
| 118 | respiratory electron transport chain (GO:0022904) | 2.91089178 |
| 119 | sodium ion export (GO:0071436) | 2.88871756 |
| 120 | protein localization to synapse (GO:0035418) | 2.87545255 |
| 121 | ventricular cardiac muscle cell action potential (GO:0086005) | 2.87466625 |
| 122 | neuromuscular synaptic transmission (GO:0007274) | 2.87019146 |
| 123 | NADH metabolic process (GO:0006734) | 2.86924471 |
| 124 | positive regulation of synapse maturation (GO:0090129) | 2.86333829 |
| 125 | regulation of synaptic vesicle exocytosis (GO:2000300) | 2.85386609 |
| 126 | negative regulation of calcium ion transmembrane transporter activity (GO:1901020) | 2.84766699 |
| 127 | negative regulation of calcium ion transmembrane transport (GO:1903170) | 2.84766699 |
| 128 | electron transport chain (GO:0022900) | 2.82794075 |
| 129 | activation of protein kinase A activity (GO:0034199) | 2.81241223 |
| 130 | cellular polysaccharide catabolic process (GO:0044247) | 2.81202987 |
| 131 | positive regulation of ion transmembrane transporter activity (GO:0032414) | 2.78991654 |
| 132 | locomotory exploration behavior (GO:0035641) | 2.78212284 |
| 133 | muscle system process (GO:0003012) | 2.77970510 |
| 134 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 2.77205936 |
| 135 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 2.76845847 |
| 136 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 2.76783020 |
| 137 | cardiac muscle hypertrophy (GO:0003300) | 2.76724654 |
| 138 | neurotransmitter-gated ion channel clustering (GO:0072578) | 2.76381262 |
| 139 | cardiac muscle cell action potential (GO:0086001) | 2.74531045 |
| 140 | regulation of glutamate receptor signaling pathway (GO:1900449) | 2.73350087 |
| 141 | striated muscle hypertrophy (GO:0014897) | 2.73063072 |
| 142 | striatum development (GO:0021756) | 2.72423442 |
| 143 | response to muscle activity (GO:0014850) | 2.71260841 |
| 144 | cardiac muscle cell action potential involved in contraction (GO:0086002) | 2.70522966 |
| 145 | regulation of synaptic vesicle transport (GO:1902803) | 2.68457372 |
| 146 | skeletal muscle fiber development (GO:0048741) | 2.68048293 |
| 147 | neurotransmitter secretion (GO:0007269) | 2.67723782 |
| 148 | ATP synthesis coupled proton transport (GO:0015986) | 2.66502707 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 4.89182189 |
| 2 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 4.76535585 |
| 3 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 3.05769584 |
| 4 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.84382002 |
| 5 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.83484009 |
| 6 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 2.59703502 |
| 7 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.59051319 |
| 8 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.57720897 |
| 9 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.51730984 |
| 10 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.41132226 |
| 11 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.41132226 |
| 12 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.38794919 |
| 13 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.38665512 |
| 14 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.37594139 |
| 15 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.37220597 |
| 16 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.34133471 |
| 17 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.30241296 |
| 18 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.27059819 |
| 19 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.21979816 |
| 20 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.21870301 |
| 21 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.14399391 |
| 22 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.11088694 |
| 23 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.07542770 |
| 24 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.02143007 |
| 25 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.94734668 |
| 26 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.91783495 |
| 27 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.91656258 |
| 28 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.89480569 |
| 29 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.86053876 |
| 30 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.75017545 |
| 31 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.71756709 |
| 32 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.66807754 |
| 33 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.64769202 |
| 34 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.60108772 |
| 35 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.59752964 |
| 36 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.50225636 |
| 37 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.49055744 |
| 38 | GATA4_21415370_ChIP-Seq_HL-1_Mouse | 1.47499913 |
| 39 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.43605124 |
| 40 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.41342331 |
| 41 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.41202526 |
| 42 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.40970114 |
| 43 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.40601927 |
| 44 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.39758761 |
| 45 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.39268830 |
| 46 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.36247277 |
| 47 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.36158900 |
| 48 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.32797760 |
| 49 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 1.31628259 |
| 50 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.29984612 |
| 51 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.27273184 |
| 52 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.25640667 |
| 53 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.23570588 |
| 54 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.22732248 |
| 55 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.21523508 |
| 56 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.20895893 |
| 57 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.20391011 |
| 58 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.18837951 |
| 59 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.18648592 |
| 60 | STAT3_19079543_ChIP-ChIP_MESCs_Mouse | 1.18109246 |
| 61 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.17140652 |
| 62 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 1.16923902 |
| 63 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 1.16923902 |
| 64 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.16441203 |
| 65 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.16086399 |
| 66 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.15942073 |
| 67 | SMC3_22415368_ChIP-Seq_MEFs_Mouse | 1.15055965 |
| 68 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.13145144 |
| 69 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.11110424 |
| 70 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.10387873 |
| 71 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.09520380 |
| 72 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.09260786 |
| 73 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.08970690 |
| 74 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.08856396 |
| 75 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.08632115 |
| 76 | AR_19668381_ChIP-Seq_PC3_Human | 1.07726858 |
| 77 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.06757921 |
| 78 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.06708701 |
| 79 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.06057188 |
| 80 | MYC_27129775_Chip-Seq_CORNEA_Mouse | 1.04691258 |
| 81 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.04647185 |
| 82 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.04479263 |
| 83 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.04232315 |
| 84 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.04197838 |
| 85 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.03311561 |
| 86 | AR_25329375_ChIP-Seq_VCAP_Human | 1.03009150 |
| 87 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.02549960 |
| 88 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.02013935 |
| 89 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.00423398 |
| 90 | VDR_22108803_ChIP-Seq_LS180_Human | 0.99189961 |
| 91 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.98264081 |
| 92 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.97429728 |
| 93 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.97258578 |
| 94 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 0.96743920 |
| 95 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.95025616 |
| 96 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.93539225 |
| 97 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 0.91744303 |
| 98 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 0.91708972 |
| 99 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.91393731 |
| 100 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.91370073 |
| 101 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 0.90655781 |
| 102 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.90059026 |
| 103 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.89952205 |
| 104 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.89229635 |
| 105 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.89115193 |
| 106 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.88586957 |
| 107 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 0.88477327 |
| 108 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 0.88058820 |
| 109 | KLF4_19829295_ChIP-Seq_ESCs_Human | 0.87600334 |
| 110 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.86859540 |
| 111 | SA1_27219007_Chip-Seq_Bcells_Human | 0.86579110 |
| 112 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 0.86370000 |
| 113 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 0.85858617 |
| 114 | CTCF_21964334_ChIP-Seq_BJAB-B_Human | 0.85798358 |
| 115 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 0.85628443 |
| 116 | P300_19829295_ChIP-Seq_ESCs_Human | 0.85515916 |
| 117 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.84603553 |
| 118 | KDM2B_26808549_Chip-Seq_DND41_Human | 0.84425760 |
| 119 | TP53_23651856_ChIP-Seq_MEFs_Mouse | 0.84380963 |
| 120 | KDM2B_26808549_Chip-Seq_K562_Human | 0.84209534 |
| 121 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.83741612 |
| 122 | DPY_21335234_ChIP-Seq_ESCs_Mouse | 0.83599931 |
| 123 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.83145814 |
| 124 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.82591984 |
| 125 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.81857863 |
| 126 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 0.81615310 |
| 127 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.81572791 |
| 128 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.81502246 |
| 129 | STAT3_23295773_ChIP-Seq_U87_Human | 0.81429726 |
| 130 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 0.81353249 |
| 131 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.81205923 |
| 132 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.80943600 |
| 133 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.80436215 |
| 134 | CLOCK_20551151_ChIP-Seq_293T_Human | 0.79817130 |
| 135 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.79179712 |
| 136 | OCT4_20526341_ChIP-Seq_ESCs_Human | 0.78826838 |
| 137 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.77887624 |
| 138 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.77787155 |
| 139 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.77736313 |
| 140 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.77291685 |
| 141 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.77214974 |
| 142 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 0.74931190 |
| 143 | OCT4_19829295_ChIP-Seq_ESCs_Human | 0.74157138 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0000751_myopathy | 4.70439798 |
| 2 | MP0002837_dystrophic_cardiac_calcinosis | 4.68138698 |
| 3 | MP0003646_muscle_fatigue | 4.64022284 |
| 4 | MP0004145_abnormal_muscle_electrophysio | 4.41507966 |
| 5 | MP0000749_muscle_degeneration | 3.89147484 |
| 6 | MP0004036_abnormal_muscle_relaxation | 3.52449846 |
| 7 | MP0004859_abnormal_synaptic_plasticity | 3.23709858 |
| 8 | MP0004084_abnormal_cardiac_muscle | 2.99849627 |
| 9 | MP0004215_abnormal_myocardial_fiber | 2.81402710 |
| 10 | MP0005451_abnormal_body_composition | 2.73657700 |
| 11 | MP0004270_analgesia | 2.63202428 |
| 12 | MP0002106_abnormal_muscle_physiology | 2.61504506 |
| 13 | MP0000747_muscle_weakness | 2.57937014 |
| 14 | MP0004233_abnormal_muscle_weight | 2.43195708 |
| 15 | MP0003880_abnormal_central_pattern | 2.41560147 |
| 16 | MP0005620_abnormal_muscle_contractility | 2.35049238 |
| 17 | MP0003635_abnormal_synaptic_transmissio | 2.22927958 |
| 18 | MP0004087_abnormal_muscle_fiber | 2.22676172 |
| 19 | MP0005369_muscle_phenotype | 2.17201462 |
| 20 | MP0002269_muscular_atrophy | 2.15957815 |
| 21 | MP0000759_abnormal_skeletal_muscle | 2.15256060 |
| 22 | MP0000750_abnormal_muscle_regeneration | 2.02596948 |
| 23 | MP0005330_cardiomyopathy | 2.01284294 |
| 24 | MP0004130_abnormal_muscle_cell | 2.00756735 |
| 25 | MP0000733_abnormal_muscle_development | 1.88292104 |
| 26 | MP0003137_abnormal_impulse_conducting | 1.81052841 |
| 27 | MP0002064_seizures | 1.80784143 |
| 28 | MP0002822_catalepsy | 1.78730878 |
| 29 | MP0009745_abnormal_behavioral_response | 1.78331265 |
| 30 | MP0002972_abnormal_cardiac_muscle | 1.77865657 |
| 31 | MP0009046_muscle_twitch | 1.73566129 |
| 32 | MP0002332_abnormal_exercise_endurance | 1.72843111 |
| 33 | MP0002063_abnormal_learning/memory/cond | 1.68622446 |
| 34 | MP0002272_abnormal_nervous_system | 1.66540357 |
| 35 | MP0004484_altered_response_of | 1.57954134 |
| 36 | MP0002734_abnormal_mechanical_nocicepti | 1.56004309 |
| 37 | MP0004085_abnormal_heartbeat | 1.51861736 |
| 38 | MP0008569_lethality_at_weaning | 1.51469857 |
| 39 | MP0008775_abnormal_heart_ventricle | 1.44842429 |
| 40 | MP0001968_abnormal_touch/_nociception | 1.44362453 |
| 41 | MP0002909_abnormal_adrenal_gland | 1.42671763 |
| 42 | MP0006036_abnormal_mitochondrial_physio | 1.41089556 |
| 43 | MP0005670_abnormal_white_adipose | 1.41001500 |
| 44 | MP0002572_abnormal_emotion/affect_behav | 1.38775829 |
| 45 | MP0001486_abnormal_startle_reflex | 1.33834015 |
| 46 | MP0001529_abnormal_vocalization | 1.33429013 |
| 47 | MP0003329_amyloid_beta_deposits | 1.31877228 |
| 48 | MP0002067_abnormal_sensory_capabilities | 1.31068594 |
| 49 | MP0000013_abnormal_adipose_tissue | 1.29113011 |
| 50 | MP0005385_cardiovascular_system_phenoty | 1.25594711 |
| 51 | MP0001544_abnormal_cardiovascular_syste | 1.25594711 |
| 52 | MP0001440_abnormal_grooming_behavior | 1.24988036 |
| 53 | MP0009780_abnormal_chondrocyte_physiolo | 1.20377438 |
| 54 | MP0005386_behavior/neurological_phenoty | 1.17432044 |
| 55 | MP0004924_abnormal_behavior | 1.17432044 |
| 56 | MP0006276_abnormal_autonomic_nervous | 1.16241074 |
| 57 | MP0005551_abnormal_eye_electrophysiolog | 1.14268273 |
| 58 | MP0002736_abnormal_nociception_after | 1.13820310 |
| 59 | MP0005423_abnormal_somatic_nervous | 1.13248103 |
| 60 | MP0004142_abnormal_muscle_tone | 1.11712223 |
| 61 | MP0004858_abnormal_nervous_system | 1.07421584 |
| 62 | MP0002735_abnormal_chemical_nociception | 1.05791857 |
| 63 | MP0010630_abnormal_cardiac_muscle | 1.04346760 |
| 64 | MP0001984_abnormal_olfaction | 1.03144915 |
| 65 | MP0006138_congestive_heart_failure | 1.02988808 |
| 66 | MP0001970_abnormal_pain_threshold | 1.01367604 |
| 67 | MP0005666_abnormal_adipose_tissue | 1.01285843 |
| 68 | MP0002108_abnormal_muscle_morphology | 1.00763528 |
| 69 | MP0002184_abnormal_innervation | 1.00447188 |
| 70 | MP0003221_abnormal_cardiomyocyte_apopto | 1.00199673 |
| 71 | MP0002971_abnormal_brown_adipose | 0.99273529 |
| 72 | MP0001501_abnormal_sleep_pattern | 0.98726771 |
| 73 | MP0001502_abnormal_circadian_rhythm | 0.98292704 |
| 74 | MP0006035_abnormal_mitochondrial_morpho | 0.97680331 |
| 75 | MP0002733_abnormal_thermal_nociception | 0.97271500 |
| 76 | MP0002090_abnormal_vision | 0.97163138 |
| 77 | MP0002234_abnormal_pharynx_morphology | 0.95986599 |
| 78 | MP0002066_abnormal_motor_capabilities/c | 0.94381944 |
| 79 | MP0000955_abnormal_spinal_cord | 0.92367934 |
| 80 | MP0006072_abnormal_retinal_apoptosis | 0.91569582 |
| 81 | MP0001905_abnormal_dopamine_level | 0.91163785 |
| 82 | MP0003633_abnormal_nervous_system | 0.91051390 |
| 83 | MP0005375_adipose_tissue_phenotype | 0.90348295 |
| 84 | MP0005646_abnormal_pituitary_gland | 0.88931995 |
| 85 | MP0004043_abnormal_pH_regulation | 0.87706365 |
| 86 | MP0004811_abnormal_neuron_physiology | 0.85369665 |
| 87 | MP0004185_abnormal_adipocyte_glucose | 0.84790866 |
| 88 | MP0002557_abnormal_social/conspecific_i | 0.84193570 |
| 89 | MP0001661_extended_life_span | 0.83849375 |
| 90 | MP0003828_pulmonary_edema | 0.83843435 |
| 91 | MP0002882_abnormal_neuron_morphology | 0.83662270 |
| 92 | MP0002127_abnormal_cardiovascular_syste | 0.83159327 |
| 93 | MP0005535_abnormal_body_temperature | 0.83142808 |
| 94 | MP0004510_myositis | 0.80251814 |
| 95 | MP0003879_abnormal_hair_cell | 0.79772229 |
| 96 | MP0002229_neurodegeneration | 0.79409685 |
| 97 | MP0003950_abnormal_plasma_membrane | 0.79035585 |
| 98 | MP0005266_abnormal_metabolism | 0.77676382 |
| 99 | MP0000003_abnormal_adipose_tissue | 0.75345501 |
| 100 | MP0000230_abnormal_systemic_arterial | 0.72472305 |
| 101 | MP0001299_abnormal_eye_distance/ | 0.71619974 |
| 102 | MP0003631_nervous_system_phenotype | 0.70844154 |
| 103 | MP0000266_abnormal_heart_morphology | 0.67981120 |
| 104 | MP0000778_abnormal_nervous_system | 0.66412597 |
| 105 | MP0005623_abnormal_meninges_morphology | 0.64664306 |
| 106 | MP0003634_abnormal_glial_cell | 0.61870053 |
| 107 | MP0000920_abnormal_myelination | 0.61759663 |
| 108 | MP0005083_abnormal_biliary_tract | 0.61544409 |
| 109 | MP0004147_increased_porphyrin_level | 0.61083413 |
| 110 | MP0005165_increased_susceptibility_to | 0.60962034 |
| 111 | MP0004885_abnormal_endolymph | 0.59596769 |
| 112 | MP0002638_abnormal_pupillary_reflex | 0.58013226 |
| 113 | MP0003045_fibrosis | 0.53806519 |
| 114 | MP0002128_abnormal_blood_circulation | 0.49236518 |
| 115 | MP0005167_abnormal_blood-brain_barrier | 0.45239596 |
| 116 | MP0002078_abnormal_glucose_homeostasis | 0.44104179 |
| 117 | MP0003279_aneurysm | 0.42333802 |
| 118 | MP0005187_abnormal_penis_morphology | 0.41454197 |
| 119 | MP0004134_abnormal_chest_morphology | 0.39413998 |
| 120 | MP0010030_abnormal_orbit_morphology | 0.35229733 |
| 121 | MP0000762_abnormal_tongue_morphology | 0.34627911 |
| 122 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.32607790 |
| 123 | MP0008874_decreased_physiological_sensi | 0.32007953 |
| 124 | MP0003705_abnormal_hypodermis_morpholog | 0.31434717 |
| 125 | MP0005334_abnormal_fat_pad | 0.31160578 |
| 126 | MP0005452_abnormal_adipose_tissue | 0.30738215 |
| 127 | MP0001346_abnormal_lacrimal_gland | 0.30612920 |
| 128 | MP0002114_abnormal_axial_skeleton | 0.29977863 |
| 129 | MP0000343_altered_response_to | 0.29864289 |
| 130 | MP0009250_abnormal_appendicular_skeleto | 0.29671422 |
| 131 | MP0003948_abnormal_gas_homeostasis | 0.29528136 |
| 132 | MP0010368_abnormal_lymphatic_system | 0.28251816 |
| 133 | MP0005166_decreased_susceptibility_to | 0.26824616 |
| 134 | MP0000372_irregular_coat_pigmentation | 0.26130824 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Exercise-induced myalgia (HP:0003738) | 7.31401988 |
| 2 | Exercise-induced muscle cramps (HP:0003710) | 6.18709379 |
| 3 | Muscle hypertrophy of the lower extremities (HP:0008968) | 5.96753587 |
| 4 | Calf muscle hypertrophy (HP:0008981) | 5.62760103 |
| 5 | Muscle fiber inclusion bodies (HP:0100299) | 5.00306326 |
| 6 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 4.85964772 |
| 7 | Sudden death (HP:0001699) | 4.64791269 |
| 8 | Abnormality of the calf musculature (HP:0001430) | 4.40161955 |
| 9 | Nemaline bodies (HP:0003798) | 4.37007846 |
| 10 | Muscle fiber splitting (HP:0003555) | 4.34579240 |
| 11 | Myoglobinuria (HP:0002913) | 4.31954409 |
| 12 | Difficulty running (HP:0009046) | 4.05997968 |
| 13 | EMG: myopathic abnormalities (HP:0003458) | 4.03753929 |
| 14 | Myotonia (HP:0002486) | 4.02180509 |
| 15 | Distal lower limb muscle weakness (HP:0009053) | 4.00076725 |
| 16 | Hyporeflexia of lower limbs (HP:0002600) | 3.98600584 |
| 17 | Type 1 muscle fiber predominance (HP:0003803) | 3.69400424 |
| 18 | Myopathic facies (HP:0002058) | 3.67382419 |
| 19 | Distal arthrogryposis (HP:0005684) | 3.58458924 |
| 20 | Muscle stiffness (HP:0003552) | 3.57660868 |
| 21 | Frequent falls (HP:0002359) | 3.34733398 |
| 22 | Round ear (HP:0100830) | 3.29969073 |
| 23 | Focal motor seizures (HP:0011153) | 3.24510335 |
| 24 | Subaortic stenosis (HP:0001682) | 3.12941664 |
| 25 | Abnormality of the left ventricular outflow tract (HP:0011103) | 3.12941664 |
| 26 | Prolonged QT interval (HP:0001657) | 3.09381216 |
| 27 | Atrial fibrillation (HP:0005110) | 3.08627209 |
| 28 | Rhabdomyolysis (HP:0003201) | 3.06645934 |
| 29 | Increased variability in muscle fiber diameter (HP:0003557) | 3.06350972 |
| 30 | Asymmetric septal hypertrophy (HP:0001670) | 3.02311159 |
| 31 | Abnormality of skeletal muscle fiber size (HP:0012084) | 3.01750001 |
| 32 | Primary atrial arrhythmia (HP:0001692) | 2.92073337 |
| 33 | Mildly elevated creatine phosphokinase (HP:0008180) | 2.91711931 |
| 34 | Generalized muscle weakness (HP:0003324) | 2.88300333 |
| 35 | Ventricular tachycardia (HP:0004756) | 2.84842994 |
| 36 | Difficulty climbing stairs (HP:0003551) | 2.82927389 |
| 37 | Supraventricular tachycardia (HP:0004755) | 2.79292800 |
| 38 | Syncope (HP:0001279) | 2.76229261 |
| 39 | Distal lower limb amyotrophy (HP:0008944) | 2.75367948 |
| 40 | Bundle branch block (HP:0011710) | 2.74747790 |
| 41 | Supraventricular arrhythmia (HP:0005115) | 2.71463530 |
| 42 | Central scotoma (HP:0000603) | 2.70904517 |
| 43 | Myokymia (HP:0002411) | 2.70862588 |
| 44 | Increased connective tissue (HP:0009025) | 2.69301156 |
| 45 | Visual hallucinations (HP:0002367) | 2.67832948 |
| 46 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.65958702 |
| 47 | Calcaneovalgus deformity (HP:0001848) | 2.64246139 |
| 48 | Bulbar palsy (HP:0001283) | 2.60522614 |
| 49 | Acute necrotizing encephalopathy (HP:0006965) | 2.54512904 |
| 50 | Ventricular fibrillation (HP:0001663) | 2.53179937 |
| 51 | Neck muscle weakness (HP:0000467) | 2.53019546 |
| 52 | Pheochromocytoma (HP:0002666) | 2.51990454 |
| 53 | Hepatocellular necrosis (HP:0001404) | 2.50409195 |
| 54 | Scapular winging (HP:0003691) | 2.49147413 |
| 55 | Weak cry (HP:0001612) | 2.48756240 |
| 56 | Palpitations (HP:0001962) | 2.45768385 |
| 57 | Abnormal EKG (HP:0003115) | 2.45499050 |
| 58 | Rimmed vacuoles (HP:0003805) | 2.41366710 |
| 59 | Ulnar deviation of the wrist (HP:0003049) | 2.40511649 |
| 60 | Abnormality of the foot musculature (HP:0001436) | 2.39046788 |
| 61 | Gowers sign (HP:0003391) | 2.38774747 |
| 62 | Slender build (HP:0001533) | 2.37696549 |
| 63 | Deformed tarsal bones (HP:0008119) | 2.33577953 |
| 64 | Neuroendocrine neoplasm (HP:0100634) | 2.33371619 |
| 65 | Lipoatrophy (HP:0100578) | 2.31878242 |
| 66 | Ventricular arrhythmia (HP:0004308) | 2.31514172 |
| 67 | Atonic seizures (HP:0010819) | 2.31356320 |
| 68 | Left ventricular hypertrophy (HP:0001712) | 2.31160967 |
| 69 | Mitochondrial inheritance (HP:0001427) | 2.30737173 |
| 70 | Spinal rigidity (HP:0003306) | 2.30148715 |
| 71 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 2.29196904 |
| 72 | Shoulder girdle muscle weakness (HP:0003547) | 2.29020747 |
| 73 | Focal seizures (HP:0007359) | 2.28657274 |
| 74 | Hepatic necrosis (HP:0002605) | 2.27900683 |
| 75 | Areflexia of lower limbs (HP:0002522) | 2.25810091 |
| 76 | Hip contracture (HP:0003273) | 2.24197107 |
| 77 | Limb-girdle muscle atrophy (HP:0003797) | 2.23860873 |
| 78 | Epileptic encephalopathy (HP:0200134) | 2.20657671 |
| 79 | Lower limb amyotrophy (HP:0007210) | 2.20476130 |
| 80 | Progressive muscle weakness (HP:0003323) | 2.20363749 |
| 81 | Muscular dystrophy (HP:0003560) | 2.20184688 |
| 82 | Absent phalangeal crease (HP:0006109) | 2.19063226 |
| 83 | Foot dorsiflexor weakness (HP:0009027) | 2.18414622 |
| 84 | Dilated cardiomyopathy (HP:0001644) | 2.16165706 |
| 85 | Increased intramyocellular lipid droplets (HP:0012240) | 2.13903606 |
| 86 | Abnormality of the calcaneus (HP:0008364) | 2.13251146 |
| 87 | Ragged-red muscle fibers (HP:0003200) | 2.13163861 |
| 88 | Heart block (HP:0012722) | 2.11343272 |
| 89 | Progressive macrocephaly (HP:0004481) | 2.10884282 |
| 90 | Waddling gait (HP:0002515) | 2.10190537 |
| 91 | Proximal amyotrophy (HP:0007126) | 2.09656263 |
| 92 | Generalized tonic-clonic seizures (HP:0002069) | 2.08888479 |
| 93 | Abnormality of the hip-girdle musculature (HP:0001445) | 2.07449994 |
| 94 | Abnormality of the musculature of the pelvis (HP:0001469) | 2.07449994 |
| 95 | Absence seizures (HP:0002121) | 2.06935944 |
| 96 | Ketoacidosis (HP:0001993) | 2.06209340 |
| 97 | Acute encephalopathy (HP:0006846) | 2.04012094 |
| 98 | Abnormality of the shoulder girdle musculature (HP:0001435) | 2.03362810 |
| 99 | Increased muscle lipid content (HP:0009058) | 2.02735910 |
| 100 | Increased CSF lactate (HP:0002490) | 2.02186997 |
| 101 | EMG: neuropathic changes (HP:0003445) | 2.00308171 |
| 102 | Exercise intolerance (HP:0003546) | 1.96801866 |
| 103 | Dialeptic seizures (HP:0011146) | 1.96195303 |
| 104 | Malignant hyperthermia (HP:0002047) | 1.95781323 |
| 105 | Ankle clonus (HP:0011448) | 1.95491799 |
| 106 | Hyperkalemia (HP:0002153) | 1.94827679 |
| 107 | Abnormal atrioventricular conduction (HP:0005150) | 1.92585195 |
| 108 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.91192626 |
| 109 | Abnormality of alanine metabolism (HP:0010916) | 1.91192626 |
| 110 | Hyperalaninemia (HP:0003348) | 1.91192626 |
| 111 | Respiratory insufficiency due to muscle weakness (HP:0002747) | 1.91079403 |
| 112 | Fetal akinesia sequence (HP:0001989) | 1.90717320 |
| 113 | Depression (HP:0000716) | 1.90213843 |
| 114 | Pelvic girdle muscle weakness (HP:0003749) | 1.90055829 |
| 115 | Anxiety (HP:0000739) | 1.89597723 |
| 116 | Poor eye contact (HP:0000817) | 1.87691093 |
| 117 | Abnormality of the neuromuscular junction (HP:0003398) | 1.83377886 |
| 118 | Fatigable weakness (HP:0003473) | 1.83377886 |
| 119 | Large for gestational age (HP:0001520) | 1.82776783 |
| 120 | Abnormal finger flexion creases (HP:0006143) | 1.82201362 |
| 121 | Atrioventricular block (HP:0001678) | 1.81825554 |
| 122 | Rapidly progressive (HP:0003678) | 1.80070283 |
| 123 | Dysmetric saccades (HP:0000641) | 1.78771053 |
| 124 | Limb-girdle muscle weakness (HP:0003325) | 1.78604925 |
| 125 | Steppage gait (HP:0003376) | 1.58283893 |
| 126 | Limited hip movement (HP:0008800) | 1.55653409 |
| 127 | Nonprogressive disorder (HP:0003680) | 1.55412739 |
| 128 | Metatarsus adductus (HP:0001840) | 1.54805483 |
| 129 | Popliteal pterygium (HP:0009756) | 1.53908361 |
| 130 | Facial diplegia (HP:0001349) | 1.51759817 |
| 131 | Type 2 muscle fiber atrophy (HP:0003554) | 1.49948793 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PHKG1 | 4.66096854 |
| 2 | PHKG2 | 4.66096854 |
| 3 | OBSCN | 3.81720197 |
| 4 | TTN | 3.63501504 |
| 5 | EPHA4 | 3.01220793 |
| 6 | NME1 | 2.41007779 |
| 7 | LMTK2 | 2.23257728 |
| 8 | MAP3K4 | 2.22588654 |
| 9 | MUSK | 2.22055074 |
| 10 | BCKDK | 2.12069318 |
| 11 | MAP3K9 | 2.08098686 |
| 12 | NTRK3 | 1.97182617 |
| 13 | PDK3 | 1.94289372 |
| 14 | PDK4 | 1.94289372 |
| 15 | MAP2K4 | 1.86602864 |
| 16 | PAK6 | 1.76535027 |
| 17 | PINK1 | 1.76066836 |
| 18 | NEK1 | 1.67881587 |
| 19 | KSR2 | 1.62905359 |
| 20 | MINK1 | 1.58975362 |
| 21 | ARAF | 1.55983391 |
| 22 | PRKD3 | 1.48514138 |
| 23 | MAP3K7 | 1.46777663 |
| 24 | MAPKAPK3 | 1.43196424 |
| 25 | MAP2K7 | 1.42360881 |
| 26 | PIK3CG | 1.40082379 |
| 27 | PDK2 | 1.32730140 |
| 28 | PIK3CA | 1.31286868 |
| 29 | PRPF4B | 1.31050812 |
| 30 | MAPK12 | 1.27251908 |
| 31 | MARK1 | 1.25806983 |
| 32 | STK38 | 1.23613305 |
| 33 | LIMK1 | 1.21336680 |
| 34 | CDK19 | 1.19422363 |
| 35 | DMPK | 1.16895764 |
| 36 | MYLK | 1.13844174 |
| 37 | CAMK2D | 1.10425170 |
| 38 | DAPK2 | 1.08371101 |
| 39 | TRPM7 | 1.08033942 |
| 40 | MAP2K6 | 0.98965568 |
| 41 | NTRK1 | 0.97830877 |
| 42 | GRK7 | 0.96277333 |
| 43 | CAMK2A | 0.95562646 |
| 44 | PAK3 | 0.94910274 |
| 45 | TNIK | 0.93507540 |
| 46 | CDK5 | 0.88298412 |
| 47 | MAP3K13 | 0.87740595 |
| 48 | NTRK2 | 0.86148284 |
| 49 | CAMKK1 | 0.85585901 |
| 50 | PTK2B | 0.82696992 |
| 51 | CAMK4 | 0.81389151 |
| 52 | INSRR | 0.80824284 |
| 53 | KSR1 | 0.80800540 |
| 54 | GRK5 | 0.80604869 |
| 55 | RIPK1 | 0.80308632 |
| 56 | DYRK1B | 0.79322807 |
| 57 | CAMK2G | 0.77348192 |
| 58 | CAMKK2 | 0.76078284 |
| 59 | TIE1 | 0.75298190 |
| 60 | EEF2K | 0.74621300 |
| 61 | MAP3K12 | 0.74404060 |
| 62 | CAMK1 | 0.73903347 |
| 63 | PRKAA2 | 0.73492326 |
| 64 | TAOK2 | 0.72428051 |
| 65 | ROCK2 | 0.68347308 |
| 66 | UHMK1 | 0.67501000 |
| 67 | MAPK13 | 0.67090161 |
| 68 | TRIB3 | 0.66533112 |
| 69 | PRKCG | 0.65775256 |
| 70 | SGK223 | 0.64689105 |
| 71 | SGK494 | 0.64689105 |
| 72 | CASK | 0.64589211 |
| 73 | PKN1 | 0.64298563 |
| 74 | MAP3K6 | 0.64259553 |
| 75 | AKT2 | 0.63471343 |
| 76 | NEK9 | 0.63396486 |
| 77 | MAPK7 | 0.62579892 |
| 78 | WNK3 | 0.61515071 |
| 79 | LATS2 | 0.61054046 |
| 80 | MOS | 0.60960886 |
| 81 | MAP2K3 | 0.60887513 |
| 82 | PRKAA1 | 0.58835087 |
| 83 | MAPK4 | 0.58164558 |
| 84 | CAMK2B | 0.57356636 |
| 85 | PDPK1 | 0.57225594 |
| 86 | PRKCH | 0.56290256 |
| 87 | CDK14 | 0.55693281 |
| 88 | PRKD1 | 0.53284398 |
| 89 | PRKACB | 0.51831195 |
| 90 | RET | 0.51523970 |
| 91 | RAF1 | 0.51348769 |
| 92 | MAP3K1 | 0.50545751 |
| 93 | CDK15 | 0.50369385 |
| 94 | CDK18 | 0.50232156 |
| 95 | PRKCE | 0.49772378 |
| 96 | MAP2K1 | 0.49608612 |
| 97 | WNK4 | 0.48868406 |
| 98 | ROCK1 | 0.47980087 |
| 99 | PDK1 | 0.47896412 |
| 100 | DYRK1A | 0.47022615 |
| 101 | PRKACA | 0.46633967 |
| 102 | CCNB1 | 0.46281480 |
| 103 | DAPK3 | 0.46099943 |
| 104 | ERBB3 | 0.45911665 |
| 105 | OXSR1 | 0.45892921 |
| 106 | WNK1 | 0.45674435 |
| 107 | CDK11A | 0.44012737 |
| 108 | PLK2 | 0.42951513 |
| 109 | SGK3 | 0.42280580 |
| 110 | ICK | 0.41305987 |
| 111 | DAPK1 | 0.41132676 |
| 112 | RPS6KA3 | 0.39999829 |
| 113 | PKN2 | 0.39485813 |
| 114 | SGK1 | 0.37825728 |
| 115 | PRKG1 | 0.37323336 |
| 116 | MARK2 | 0.37057019 |
| 117 | RIPK4 | 0.35902227 |
| 118 | MAP3K11 | 0.33967425 |
| 119 | SGK2 | 0.33412165 |
| 120 | BRAF | 0.31162969 |
| 121 | MAPK11 | 0.31115486 |
| 122 | MAPK10 | 0.29345243 |
| 123 | RPS6KC1 | 0.27988643 |
| 124 | RPS6KL1 | 0.27988643 |
| 125 | PRKACG | 0.22403898 |
| 126 | RPS6KA6 | 0.20834200 |
| 127 | MAP3K5 | 0.20376092 |
| 128 | STK11 | 0.19824530 |
| 129 | TGFBR2 | 0.17963927 |
| 130 | RPS6KB1 | 0.17095881 |
| 131 | RPS6KA1 | 0.16790397 |
| 132 | TBK1 | 0.15527306 |
| 133 | SIK1 | 0.15169787 |
| 134 | EPHB1 | 0.12666477 |
| 135 | CDC42BPA | 0.12421917 |
| 136 | RPS6KA2 | 0.11827258 |
| 137 | TESK1 | 0.09954434 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 3.24733367 |
| 2 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 3.15736127 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.56092160 |
| 4 | Parkinsons disease_Homo sapiens_hsa05012 | 2.38842659 |
| 5 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 2.36124583 |
| 6 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.25741894 |
| 7 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 2.19964276 |
| 8 | Nicotine addiction_Homo sapiens_hsa05033 | 2.18161003 |
| 9 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 2.09693035 |
| 10 | Alzheimers disease_Homo sapiens_hsa05010 | 2.08968770 |
| 11 | GABAergic synapse_Homo sapiens_hsa04727 | 2.07864507 |
| 12 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.03092765 |
| 13 | Circadian entrainment_Homo sapiens_hsa04713 | 1.99897233 |
| 14 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.97154404 |
| 15 | Insulin secretion_Homo sapiens_hsa04911 | 1.84385703 |
| 16 | Olfactory transduction_Homo sapiens_hsa04740 | 1.75532681 |
| 17 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.73588431 |
| 18 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.72885659 |
| 19 | Morphine addiction_Homo sapiens_hsa05032 | 1.72745977 |
| 20 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.68901766 |
| 21 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.63901008 |
| 22 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.61538602 |
| 23 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.59095945 |
| 24 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.53912213 |
| 25 | Salivary secretion_Homo sapiens_hsa04970 | 1.51044126 |
| 26 | Long-term potentiation_Homo sapiens_hsa04720 | 1.50819298 |
| 27 | Renin secretion_Homo sapiens_hsa04924 | 1.50172737 |
| 28 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.46547065 |
| 29 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.43310581 |
| 30 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.42281232 |
| 31 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.41220524 |
| 32 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.38755284 |
| 33 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.38639936 |
| 34 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.38178395 |
| 35 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.38069099 |
| 36 | Huntingtons disease_Homo sapiens_hsa05016 | 1.34338304 |
| 37 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.31438473 |
| 38 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.29786593 |
| 39 | Taste transduction_Homo sapiens_hsa04742 | 1.26790674 |
| 40 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.24751481 |
| 41 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.22936359 |
| 42 | Pancreatic secretion_Homo sapiens_hsa04972 | 1.21762399 |
| 43 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.20064552 |
| 44 | Carbon metabolism_Homo sapiens_hsa01200 | 1.18007370 |
| 45 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 1.17334783 |
| 46 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 1.14765292 |
| 47 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.10811587 |
| 48 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.10662253 |
| 49 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.07659937 |
| 50 | Gap junction_Homo sapiens_hsa04540 | 1.06621813 |
| 51 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.05073152 |
| 52 | Circadian rhythm_Homo sapiens_hsa04710 | 1.04869276 |
| 53 | Long-term depression_Homo sapiens_hsa04730 | 0.96958971 |
| 54 | Cocaine addiction_Homo sapiens_hsa05030 | 0.96232920 |
| 55 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.94423484 |
| 56 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.91269503 |
| 57 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.87570993 |
| 58 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.87352975 |
| 59 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.86990604 |
| 60 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.86292183 |
| 61 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.85113326 |
| 62 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.84860416 |
| 63 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.84287094 |
| 64 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.81321025 |
| 65 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.80398442 |
| 66 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.78980939 |
| 67 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.76290372 |
| 68 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.74757232 |
| 69 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.73157914 |
| 70 | Focal adhesion_Homo sapiens_hsa04510 | 0.67604238 |
| 71 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.66517719 |
| 72 | Melanogenesis_Homo sapiens_hsa04916 | 0.64552155 |
| 73 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.62890220 |
| 74 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.61981508 |
| 75 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.60962013 |
| 76 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.60784251 |
| 77 | Viral myocarditis_Homo sapiens_hsa05416 | 0.59996233 |
| 78 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.59635564 |
| 79 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.58377702 |
| 80 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.57835648 |
| 81 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.57766114 |
| 82 | Phototransduction_Homo sapiens_hsa04744 | 0.55285890 |
| 83 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.55230100 |
| 84 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.55214861 |
| 85 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.55011018 |
| 86 | Insulin resistance_Homo sapiens_hsa04931 | 0.54367536 |
| 87 | Galactose metabolism_Homo sapiens_hsa00052 | 0.51681610 |
| 88 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.49062449 |
| 89 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.48925051 |
| 90 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.46483221 |
| 91 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.44839118 |
| 92 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.44065811 |
| 93 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.43969441 |
| 94 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.41327941 |
| 95 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.41096051 |
| 96 | Axon guidance_Homo sapiens_hsa04360 | 0.39186509 |
| 97 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.39035412 |
| 98 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.38120158 |
| 99 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.38067109 |
| 100 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.37225462 |
| 101 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.36847326 |
| 102 | Platelet activation_Homo sapiens_hsa04611 | 0.36727965 |
| 103 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.36286504 |
| 104 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.33936002 |
| 105 | Glioma_Homo sapiens_hsa05214 | 0.32876237 |
| 106 | Tight junction_Homo sapiens_hsa04530 | 0.31852674 |
| 107 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.31508234 |
| 108 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.31156960 |
| 109 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.30814766 |
| 110 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.30684659 |
| 111 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.30413877 |
| 112 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.30303761 |
| 113 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.29435831 |
| 114 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.29351540 |
| 115 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.29202359 |
| 116 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.29049745 |
| 117 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.27782101 |
| 118 | Bile secretion_Homo sapiens_hsa04976 | 0.24892875 |
| 119 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.24642753 |
| 120 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.23250130 |
| 121 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.21217744 |
| 122 | Peroxisome_Homo sapiens_hsa04146 | 0.21150758 |
| 123 | Amoebiasis_Homo sapiens_hsa05146 | 0.20835676 |

