PLPPR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the plasticity-related gene (PRG) family. Members of the PRG family mediate lipid phosphate phosphatase activity in neurons and are known to be involved in neuronal plasticity. The protein encoded by this gene does not perform its function through enzymatic phospholipid degradation. This gene is strongly expressed in brain. It shows dynamic expression regulation during brain development and neuronal excitation. Alternatively spliced transcript variants encoding the same protein have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)6.54432978
2vocalization behavior (GO:0071625)5.98548770
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.26897925
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.22193002
5protein localization to synapse (GO:0035418)5.13083872
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.09951645
7neuron recognition (GO:0008038)4.91597437
8regulation of synapse structural plasticity (GO:0051823)4.90333830
9pyrimidine nucleobase catabolic process (GO:0006208)4.88607426
10positive regulation of action potential (GO:0045760)4.83546583
11regulation of glutamate receptor signaling pathway (GO:1900449)4.74628868
12neurotransmitter-gated ion channel clustering (GO:0072578)4.58298065
13negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.54502058
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.53079068
15dendritic spine morphogenesis (GO:0060997)4.46122868
16regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.44599993
17axonal fasciculation (GO:0007413)4.40951088
18synaptic vesicle exocytosis (GO:0016079)4.38197244
19postsynaptic membrane organization (GO:0001941)4.36732520
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.26425561
21central nervous system projection neuron axonogenesis (GO:0021952)4.24269182
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.15819000
23locomotory exploration behavior (GO:0035641)4.14041752
24righting reflex (GO:0060013)4.11996432
25layer formation in cerebral cortex (GO:0021819)4.11869088
26response to pheromone (GO:0019236)4.11100499
27presynaptic membrane assembly (GO:0097105)4.10808659
28synaptic transmission, glutamatergic (GO:0035249)4.09888056
29regulation of long-term neuronal synaptic plasticity (GO:0048169)4.01640842
30startle response (GO:0001964)4.00517032
31neuron-neuron synaptic transmission (GO:0007270)3.98489617
32tachykinin receptor signaling pathway (GO:0007217)3.97251092
33neurotransmitter secretion (GO:0007269)3.96190202
34glutamate receptor signaling pathway (GO:0007215)3.95999680
35exploration behavior (GO:0035640)3.95874563
36negative regulation of dendrite development (GO:2000171)3.94499475
37glutamate secretion (GO:0014047)3.90762671
38positive regulation of synapse maturation (GO:0090129)3.89399014
39nucleobase catabolic process (GO:0046113)3.87051268
40regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.86426285
41regulation of synaptic vesicle exocytosis (GO:2000300)3.83962682
42establishment of mitochondrion localization (GO:0051654)3.80680890
43cell migration in hindbrain (GO:0021535)3.78253296
44drinking behavior (GO:0042756)3.78160917
45presynaptic membrane organization (GO:0097090)3.75013544
46regulation of neuronal synaptic plasticity (GO:0048168)3.74924372
47positive regulation of synapse assembly (GO:0051965)3.74571233
48regulation of synaptic transmission, glutamatergic (GO:0051966)3.72978549
49synaptic vesicle maturation (GO:0016188)3.69891171
50regulation of respiratory system process (GO:0044065)3.66269802
51regulation of excitatory postsynaptic membrane potential (GO:0060079)3.61542470
52behavioral fear response (GO:0001662)3.57673168
53behavioral defense response (GO:0002209)3.57673168
54dendrite morphogenesis (GO:0048813)3.54900820
55synapse assembly (GO:0007416)3.53926944
56glycosphingolipid biosynthetic process (GO:0006688)3.48599458
57regulation of action potential (GO:0098900)3.47737067
58gamma-aminobutyric acid transport (GO:0015812)3.47486511
59positive regulation of membrane potential (GO:0045838)3.47452027
60neuronal action potential propagation (GO:0019227)3.46831039
61regulation of postsynaptic membrane potential (GO:0060078)3.46547981
62regulation of synapse maturation (GO:0090128)3.44265817
63auditory behavior (GO:0031223)3.44110056
64transmission of nerve impulse (GO:0019226)3.41608860
65G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.41224552
66negative regulation of synaptic transmission, GABAergic (GO:0032229)3.39747239
67urinary tract smooth muscle contraction (GO:0014848)3.36725525
68regulation of synaptic vesicle transport (GO:1902803)3.35385624
69positive regulation of synaptic transmission, GABAergic (GO:0032230)3.31012694
70fear response (GO:0042596)3.27608286
71positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.27585093
72regulation of synapse assembly (GO:0051963)3.27583094
73behavioral response to cocaine (GO:0048148)3.27442026
74cerebellum development (GO:0021549)3.26776201
75synaptic vesicle docking involved in exocytosis (GO:0016081)3.23183583
76regulation of synaptic transmission, GABAergic (GO:0032228)3.21575347
77central nervous system neuron axonogenesis (GO:0021955)3.21435776
78proline transport (GO:0015824)3.19390856
79membrane hyperpolarization (GO:0060081)3.19339346
80regulation of dendritic spine morphogenesis (GO:0061001)3.19006877
81striatum development (GO:0021756)3.18639056
82neurotransmitter transport (GO:0006836)3.17993863
83regulation of synapse organization (GO:0050807)3.17831882
84adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.17525497
85regulation of respiratory gaseous exchange (GO:0043576)3.16251457
86response to auditory stimulus (GO:0010996)3.13131846
87learning (GO:0007612)3.11920137
88prepulse inhibition (GO:0060134)3.11376068
89limb bud formation (GO:0060174)3.08254472
90neuronal action potential (GO:0019228)3.07599842
91positive regulation of neurotransmitter secretion (GO:0001956)3.06853976
92axon extension (GO:0048675)3.06307113
93adult walking behavior (GO:0007628)3.02999360
94membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.02929589
95positive regulation of neurotransmitter transport (GO:0051590)3.02418373
96positive regulation of amino acid transport (GO:0051957)3.01980616
97long-term memory (GO:0007616)3.01006740
98establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.00746931
99mitochondrion transport along microtubule (GO:0047497)3.00746931
100negative regulation of microtubule polymerization (GO:0031115)2.98947849
101mechanosensory behavior (GO:0007638)2.98476958
102synapse organization (GO:0050808)2.98381897
103positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.97673661
104dopamine receptor signaling pathway (GO:0007212)2.97294090
105negative regulation of axon extension (GO:0030517)2.97003336
106regulation of neurotransmitter levels (GO:0001505)2.96424161
107axon ensheathment in central nervous system (GO:0032291)2.95285549
108central nervous system myelination (GO:0022010)2.95285549
109positive regulation of dendritic spine development (GO:0060999)2.95259215
110cerebellar granule cell differentiation (GO:0021707)2.94939141
111membrane depolarization (GO:0051899)2.94257235
112regulation of neurotransmitter secretion (GO:0046928)2.93860172
113regulation of dopamine secretion (GO:0014059)2.93357986
114long-term synaptic potentiation (GO:0060291)2.91437955
115response to histamine (GO:0034776)2.90984760
116positive regulation of dendritic spine morphogenesis (GO:0061003)2.89717481
117neuronal ion channel clustering (GO:0045161)2.89491004
118negative regulation of dendrite morphogenesis (GO:0050774)2.88865971
119regulation of collateral sprouting (GO:0048670)2.85359653
120reflex (GO:0060004)2.83630121
121positive regulation of vascular permeability (GO:0043117)2.82301706
122membrane depolarization during action potential (GO:0086010)2.80587366
123neurofilament cytoskeleton organization (GO:0060052)2.74399461
124behavioral response to ethanol (GO:0048149)2.73826690
125behavioral response to nicotine (GO:0035095)2.67575104
126regulation of timing of cell differentiation (GO:0048505)2.67389841
127C4-dicarboxylate transport (GO:0015740)2.66645553
128inositol phosphate catabolic process (GO:0071545)2.63125822
129retinal cone cell development (GO:0046549)2.62275544
130regulation of development, heterochronic (GO:0040034)2.61838112
131retinal ganglion cell axon guidance (GO:0031290)2.61276504
132negative regulation of axonogenesis (GO:0050771)2.61077352
133positive regulation of digestive system process (GO:0060456)2.60308983
134regulation of vesicle fusion (GO:0031338)2.59432971
135negative regulation of synaptic transmission (GO:0050805)2.58560981
136regulation of axon guidance (GO:1902667)2.57842983

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.59415718
2GBX2_23144817_ChIP-Seq_PC3_Human4.14970062
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.05144651
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.04353366
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.89049999
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.85729001
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.76425309
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60047715
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.57719329
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.57079530
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55111331
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51416419
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51416419
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50067025
15REST_21632747_ChIP-Seq_MESCs_Mouse2.42978243
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.42202473
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.40320660
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.36513173
19TAF15_26573619_Chip-Seq_HEK293_Human2.29925676
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29762193
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.28535146
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26631090
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19447307
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17320481
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.12392167
26ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09062431
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.08318438
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.97696948
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95808771
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.95500138
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.92019000
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90935036
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.83588784
34DROSHA_22980978_ChIP-Seq_HELA_Human1.83578910
35AR_21572438_ChIP-Seq_LNCaP_Human1.80714524
36IGF1R_20145208_ChIP-Seq_DFB_Human1.78345618
37P300_19829295_ChIP-Seq_ESCs_Human1.65870948
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.65687021
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65323581
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64818019
41SMAD4_21799915_ChIP-Seq_A2780_Human1.62504629
42RNF2_27304074_Chip-Seq_NSC_Mouse1.59340955
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.59179686
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54733024
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50681305
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41956063
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.40381641
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39701016
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39649576
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38021380
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.36226041
52SOX2_21211035_ChIP-Seq_LN229_Gbm1.35652094
53EWS_26573619_Chip-Seq_HEK293_Human1.34871833
54RING1B_27294783_Chip-Seq_ESCs_Mouse1.34595309
55FUS_26573619_Chip-Seq_HEK293_Human1.32070012
56ZNF274_21170338_ChIP-Seq_K562_Hela1.31314527
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.30930282
58BCAT_22108803_ChIP-Seq_LS180_Human1.29372141
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28339861
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27665848
61AR_25329375_ChIP-Seq_VCAP_Human1.26977527
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24468859
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.23309666
64CBP_20019798_ChIP-Seq_JUKART_Human1.23020280
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23020280
66MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22046379
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.21561667
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20669559
69RING1B_27294783_Chip-Seq_NPCs_Mouse1.19863366
70ERG_21242973_ChIP-ChIP_JURKAT_Human1.19670079
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19556651
72AHR_22903824_ChIP-Seq_MCF-7_Human1.18639536
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17678030
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16343187
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14321018
76TAL1_26923725_Chip-Seq_HPCs_Mouse1.14079660
77RUNX2_22187159_ChIP-Seq_PCA_Human1.12614763
78PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12576491
79JUN_21703547_ChIP-Seq_K562_Human1.12575972
80YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11806475
81STAT3_23295773_ChIP-Seq_U87_Human1.10088274
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10014190
83P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09867907
84ER_23166858_ChIP-Seq_MCF-7_Human1.09671718
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09063846
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08541533
87TCF4_23295773_ChIP-Seq_U87_Human1.08528012
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07908618
89RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07904954
90STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07820205
91VDR_22108803_ChIP-Seq_LS180_Human1.07279551
92AR_19668381_ChIP-Seq_PC3_Human1.06799164
93PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06526627
94LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04457104
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03887595
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02963573
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02681058
98TCF4_22108803_ChIP-Seq_LS180_Human1.02428584
99SOX9_26525672_Chip-Seq_HEART_Mouse1.02296542
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02122625
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02122625
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01987632
103P53_22387025_ChIP-Seq_ESCs_Mouse1.01422932
104NANOG_18555785_Chip-Seq_ESCs_Mouse0.98664662
105ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98528462
106MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97390034
107RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96721954
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95860011
109CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94956320
110KDM2B_26808549_Chip-Seq_REH_Human0.93278486
111GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93273745
112SMAD3_21741376_ChIP-Seq_ESCs_Human0.91501582
113SMAD_19615063_ChIP-ChIP_OVARY_Human0.89856416
114KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.89464578
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88169700
116CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.87990595
117FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87377919
118PRDM14_20953172_ChIP-Seq_ESCs_Human0.87324742
119TP53_20018659_ChIP-ChIP_R1E_Mouse0.86341973
120WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86288577

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.92052046
2MP0003880_abnormal_central_pattern4.28505333
3MP0002822_catalepsy3.93864383
4MP0003635_abnormal_synaptic_transmissio3.65482233
5MP0004270_analgesia3.25608663
6MP0002063_abnormal_learning/memory/cond3.23262946
7MP0009745_abnormal_behavioral_response3.08626647
8MP0005423_abnormal_somatic_nervous2.88645207
9MP0002572_abnormal_emotion/affect_behav2.85451491
10MP0002064_seizures2.71725240
11MP0000778_abnormal_nervous_system2.67216065
12MP0001984_abnormal_olfaction2.65150559
13MP0001968_abnormal_touch/_nociception2.58847364
14MP0001486_abnormal_startle_reflex2.56531852
15MP0002734_abnormal_mechanical_nocicepti2.54065409
16MP0002735_abnormal_chemical_nociception2.51335412
17MP0006276_abnormal_autonomic_nervous2.48347053
18MP0002272_abnormal_nervous_system2.28769726
19MP0002736_abnormal_nociception_after2.27954101
20MP0009046_muscle_twitch2.22260932
21MP0002184_abnormal_innervation2.21908610
22MP0001529_abnormal_vocalization2.16910337
23MP0001501_abnormal_sleep_pattern2.01336481
24MP0002557_abnormal_social/conspecific_i2.00535407
25MP0001188_hyperpigmentation1.95773579
26MP0002067_abnormal_sensory_capabilities1.92227402
27MP0001440_abnormal_grooming_behavior1.89809622
28MP0002733_abnormal_thermal_nociception1.83348483
29MP0001970_abnormal_pain_threshold1.79426734
30MP0003121_genomic_imprinting1.75629739
31MP0005386_behavior/neurological_phenoty1.73788322
32MP0004924_abnormal_behavior1.73788322
33MP0000955_abnormal_spinal_cord1.73295270
34MP0004811_abnormal_neuron_physiology1.68554505
35MP0005645_abnormal_hypothalamus_physiol1.67240297
36MP0005646_abnormal_pituitary_gland1.63959582
37MP0003011_delayed_dark_adaptation1.53203821
38MP0002882_abnormal_neuron_morphology1.52154351
39MP0004858_abnormal_nervous_system1.44999771
40MP0005084_abnormal_gallbladder_morpholo1.42994673
41MP0006292_abnormal_olfactory_placode1.38199778
42MP0002066_abnormal_motor_capabilities/c1.35764808
43MP0010386_abnormal_urinary_bladder1.34177951
44MP0002909_abnormal_adrenal_gland1.34005686
45MP0004885_abnormal_endolymph1.33722129
46MP0005253_abnormal_eye_physiology1.31917148
47MP0004142_abnormal_muscle_tone1.28865997
48MP0009780_abnormal_chondrocyte_physiolo1.26944128
49MP0002152_abnormal_brain_morphology1.25694184
50MP0008569_lethality_at_weaning1.25550828
51MP0003879_abnormal_hair_cell1.23306165
52MP0000631_abnormal_neuroendocrine_gland1.22033473
53MP0003122_maternal_imprinting1.21389213
54MP0001502_abnormal_circadian_rhythm1.19776590
55MP0005499_abnormal_olfactory_system1.19238421
56MP0005394_taste/olfaction_phenotype1.19238421
57MP0001905_abnormal_dopamine_level1.19227311
58MP0002638_abnormal_pupillary_reflex1.18154914
59MP0004742_abnormal_vestibular_system1.17734982
60MP0005367_renal/urinary_system_phenotyp1.11975845
61MP0000516_abnormal_urinary_system1.11975845
62MP0002752_abnormal_somatic_nervous1.06300169
63MP0002837_dystrophic_cardiac_calcinosis1.05741732
64MP0002069_abnormal_eating/drinking_beha1.05603115
65MP0003329_amyloid_beta_deposits1.03248370
66MP0003787_abnormal_imprinting1.02547771
67MP0001177_atelectasis1.00919424
68MP0002102_abnormal_ear_morphology0.98649224
69MP0003861_abnormal_nervous_system0.97859886
70MP0005379_endocrine/exocrine_gland_phen0.97262815
71MP0004085_abnormal_heartbeat0.95960786
72MP0008789_abnormal_olfactory_epithelium0.95597144
73MP0000751_myopathy0.93850612
74MP0008877_abnormal_DNA_methylation0.93122054
75MP0001986_abnormal_taste_sensitivity0.93083902
76MP0005083_abnormal_biliary_tract0.90499984
77MP0003632_abnormal_nervous_system0.89025237
78MP0001963_abnormal_hearing_physiology0.88949267
79MP0002751_abnormal_autonomic_nervous0.88203827
80MP0005195_abnormal_posterior_eye0.88037172
81MP0008872_abnormal_physiological_respon0.87467568
82MP0000026_abnormal_inner_ear0.85917907
83MP0005551_abnormal_eye_electrophysiolog0.83942700
84MP0005409_darkened_coat_color0.83790597
85MP0000537_abnormal_urethra_morphology0.82969549
86MP0003890_abnormal_embryonic-extraembry0.81772632
87MP0003634_abnormal_glial_cell0.81765782
88MP0003137_abnormal_impulse_conducting0.80522315
89MP0003690_abnormal_glial_cell0.79854875
90MP0005085_abnormal_gallbladder_physiolo0.79500833
91MP0004133_heterotaxia0.78543917
92MP0003938_abnormal_ear_development0.76840214
93MP0003718_maternal_effect0.76396325
94MP0003195_calcinosis0.74882214
95MP0000569_abnormal_digit_pigmentation0.74158395
96MP0002876_abnormal_thyroid_physiology0.72842211
97MP0003119_abnormal_digestive_system0.72790568
98MP0003283_abnormal_digestive_organ0.72374674
99MP0005365_abnormal_bile_salt0.70713542
100MP0006072_abnormal_retinal_apoptosis0.70131087
101MP0002928_abnormal_bile_duct0.70121837
102MP0000639_abnormal_adrenal_gland0.70121254
103MP0002229_neurodegeneration0.68336471
104MP0010770_preweaning_lethality0.68180743
105MP0002082_postnatal_lethality0.68180743
106MP0000538_abnormal_urinary_bladder0.67897789
107MP0005187_abnormal_penis_morphology0.67789277
108MP0000920_abnormal_myelination0.67324816
109MP0003136_yellow_coat_color0.66796966
110MP0002234_abnormal_pharynx_morphology0.66666236
111MP0002653_abnormal_ependyma_morphology0.65715171
112MP0005171_absent_coat_pigmentation0.63343644
113MP0010769_abnormal_survival0.62719806
114MP0003631_nervous_system_phenotype0.61611014
115MP0003633_abnormal_nervous_system0.61548839
116MP0008961_abnormal_basal_metabolism0.61509929
117MP0000566_synostosis0.61335137
118MP0010768_mortality/aging0.59686860
119MP0001943_abnormal_respiration0.59563447
120MP0002081_perinatal_lethality0.58997998
121MP0003385_abnormal_body_wall0.57312740

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.31776946
2Myokymia (HP:0002411)4.95260589
3Hyperventilation (HP:0002883)4.56839008
4Focal seizures (HP:0007359)4.49173596
5Epileptic encephalopathy (HP:0200134)4.42467549
6Febrile seizures (HP:0002373)4.14170554
7Broad-based gait (HP:0002136)3.84264746
8Visual hallucinations (HP:0002367)3.71930524
9Atonic seizures (HP:0010819)3.31681342
10Protruding tongue (HP:0010808)3.28849486
11Oligodactyly (hands) (HP:0001180)3.21785527
12Progressive cerebellar ataxia (HP:0002073)3.20745243
13Amblyopia (HP:0000646)3.19791446
14Degeneration of the lateral corticospinal tracts (HP:0002314)3.18108580
15Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.18108580
16Excessive salivation (HP:0003781)3.17780900
17Drooling (HP:0002307)3.17780900
18Shoulder girdle muscle weakness (HP:0003547)3.15838675
19Polyphagia (HP:0002591)3.14168084
20Poor eye contact (HP:0000817)3.01816601
21Generalized tonic-clonic seizures (HP:0002069)3.00293618
22Limb dystonia (HP:0002451)2.97140842
23Amyotrophic lateral sclerosis (HP:0007354)2.93927249
24Impaired social interactions (HP:0000735)2.89663651
25Abnormal social behavior (HP:0012433)2.89663651
26Lissencephaly (HP:0001339)2.89452783
27Hepatoblastoma (HP:0002884)2.88766623
28Absence seizures (HP:0002121)2.83434495
29Fetal akinesia sequence (HP:0001989)2.78053032
30Hypoplasia of the brainstem (HP:0002365)2.75235269
31Aplasia/Hypoplasia of the brainstem (HP:0007362)2.75235269
32Mutism (HP:0002300)2.75156495
33Gait imbalance (HP:0002141)2.73437658
34Impaired vibration sensation in the lower limbs (HP:0002166)2.73010112
35Termporal pattern (HP:0011008)2.71715075
36Insidious onset (HP:0003587)2.71715075
37Abnormal eating behavior (HP:0100738)2.68436913
38Absent speech (HP:0001344)2.66632859
39Morphological abnormality of the middle ear (HP:0008609)2.64921789
40Akinesia (HP:0002304)2.64745291
41Dialeptic seizures (HP:0011146)2.64669311
42Progressive inability to walk (HP:0002505)2.64651527
43Ankle clonus (HP:0011448)2.63595070
44Abnormality of the lower motor neuron (HP:0002366)2.62145430
45Epileptiform EEG discharges (HP:0011182)2.55285926
46Agitation (HP:0000713)2.50424460
47EEG with generalized epileptiform discharges (HP:0011198)2.49945094
48Hypsarrhythmia (HP:0002521)2.45814287
49Hypoventilation (HP:0002791)2.45715555
50Supranuclear gaze palsy (HP:0000605)2.35901287
51Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.31330180
52Abnormality of the corticospinal tract (HP:0002492)2.30808250
53Morphological abnormality of the pyramidal tract (HP:0002062)2.30788562
54Blue irides (HP:0000635)2.28604632
55Dysdiadochokinesis (HP:0002075)2.28071806
56Hypothermia (HP:0002045)2.27121774
57Hyperthyroidism (HP:0000836)2.26540538
58Anxiety (HP:0000739)2.25588411
59Failure to thrive in infancy (HP:0001531)2.23935684
60Gaze-evoked nystagmus (HP:0000640)2.23336025
61Exotropia (HP:0000577)2.23052152
62Urinary urgency (HP:0000012)2.23051553
63Urinary bladder sphincter dysfunction (HP:0002839)2.21954303
64Inability to walk (HP:0002540)2.21219359
65Spastic gait (HP:0002064)2.20550020
66Abnormality of binocular vision (HP:0011514)2.18590364
67Diplopia (HP:0000651)2.18590364
68Action tremor (HP:0002345)2.17244120
69Truncal ataxia (HP:0002078)2.16916852
70Genetic anticipation (HP:0003743)2.16548918
71Esotropia (HP:0000565)2.14443629
72Intestinal atresia (HP:0011100)2.14182285
73Retinal dysplasia (HP:0007973)2.13931367
74Stereotypic behavior (HP:0000733)2.13138194
75Type II lissencephaly (HP:0007260)2.12828382
76Atrophy/Degeneration involving motor neurons (HP:0007373)2.10321900
77Depression (HP:0000716)2.10251338
78Torticollis (HP:0000473)2.09879326
79Poor suck (HP:0002033)2.09814991
80Vitreoretinal degeneration (HP:0000655)2.07521705
81Inappropriate behavior (HP:0000719)2.06524213
82Abnormality of salivation (HP:0100755)2.05519122
83Sleep apnea (HP:0010535)2.05380253
84Hemiparesis (HP:0001269)2.04546583
85Specific learning disability (HP:0001328)2.02907076
86Sporadic (HP:0003745)2.00485701
87Neuronal loss in central nervous system (HP:0002529)2.00018210
88Abnormal hair whorl (HP:0010721)1.99399399
89Epidermoid cyst (HP:0200040)1.95876012
90True hermaphroditism (HP:0010459)1.95263734
91Congenital primary aphakia (HP:0007707)1.94973116
92Intention tremor (HP:0002080)1.94136749
93Medial flaring of the eyebrow (HP:0010747)1.93965685
94Pendular nystagmus (HP:0012043)1.93440990
95Congenital malformation of the right heart (HP:0011723)1.93129708
96Double outlet right ventricle (HP:0001719)1.93129708
97Muscular hypotonia of the trunk (HP:0008936)1.93094916
98Abnormality of midbrain morphology (HP:0002418)1.91725922
99Molar tooth sign on MRI (HP:0002419)1.91725922
100Hypoplasia of the corpus callosum (HP:0002079)1.91329736
101Autism (HP:0000717)1.89636311
102Spastic tetraplegia (HP:0002510)1.88549195
103Nephronophthisis (HP:0000090)1.88196949
104Lower limb muscle weakness (HP:0007340)1.86867285
105Nephrogenic diabetes insipidus (HP:0009806)1.86100530
106Oligodactyly (HP:0012165)1.85288959
107Abnormality of the pubic bones (HP:0003172)1.85078791
108Megalencephaly (HP:0001355)1.82011543
109Vaginal atresia (HP:0000148)1.81392079
110Focal dystonia (HP:0004373)1.81252545
111Anophthalmia (HP:0000528)1.80064655
112Cutaneous finger syndactyly (HP:0010554)1.79155088
113Pachygyria (HP:0001302)1.78324700
114Alacrima (HP:0000522)1.78127864
115Genital tract atresia (HP:0001827)1.77716843
116Obstructive sleep apnea (HP:0002870)1.77605389
117Pheochromocytoma (HP:0002666)1.77568301
118Incomplete penetrance (HP:0003829)1.77364210
119Neoplasm of the oral cavity (HP:0100649)1.76621653
120Renal hypoplasia (HP:0000089)1.76378321
121Decreased lacrimation (HP:0000633)1.75160627
122Optic nerve hypoplasia (HP:0000609)1.75019366
123Gastroesophageal reflux (HP:0002020)1.74703037
124Pancreatic cysts (HP:0001737)1.74586339
125Status epilepticus (HP:0002133)1.74336805
126Abolished electroretinogram (ERG) (HP:0000550)1.73071386
127Craniofacial dystonia (HP:0012179)1.72745787
128Bony spicule pigmentary retinopathy (HP:0007737)1.72331588
129Neurofibrillary tangles (HP:0002185)1.72258513
130Truncus arteriosus (HP:0001660)1.70572474
131Cerebral inclusion bodies (HP:0100314)1.68427072
132Delayed gross motor development (HP:0002194)1.68017057
133Abnormality of the labia minora (HP:0012880)1.67909732
134Bradycardia (HP:0001662)1.65778018

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.34067841
2NTRK34.07168203
3CASK3.91656283
4EPHA43.08723979
5FRK2.62792513
6MAPK132.58808098
7NTRK22.57473938
8MAP3K42.26661360
9MINK12.22490313
10MAP4K22.19452034
11MAP2K72.15979772
12KSR12.14162988
13SIK32.11979035
14SIK22.11619990
15MAP3K122.00994322
16UHMK11.99105524
17TNIK1.97086717
18MAP3K91.88969011
19CAMKK11.82999811
20DYRK21.75339372
21PINK11.72208727
22DAPK21.59202012
23PHKG21.52936208
24PHKG11.52936208
25BCR1.39963981
26ERBB31.39688332
27FGFR21.38957736
28CDK51.38007306
29PLK21.37649603
30CAMKK21.32061047
31LIMK11.28910069
32TRIM281.26643568
33GRK51.26508766
34MAP2K41.26306495
35PAK61.24418887
36PNCK1.15959390
37PRPF4B1.14791635
38PRKCG1.10092491
39STK161.09940064
40ADRBK21.07144810
41DAPK11.05519187
42DYRK1A1.04139281
43SGK21.03573540
44SGK4941.02025852
45SGK2231.02025852
46EPHA31.00090998
47AKT30.97335600
48CSNK1G20.95527205
49CAMK2A0.95361300
50WNK30.94640664
51NTRK10.92337433
52IRAK20.92309274
53CAMK1G0.92151127
54PRKCE0.89569731
55EPHB20.86782522
56CSNK1A1L0.81820990
57KSR20.80257885
58CCNB10.78390238
59BMPR1B0.77973369
60CDK180.77484722
61MAP3K20.76092895
62INSRR0.74450074
63CAMK2B0.71890648
64MARK20.70885537
65SGK10.70213126
66FES0.70003162
67CDK140.69949491
68PRKCZ0.69507824
69PRKD30.69095631
70CDK150.68289484
71PKN10.67136203
72CAMK2D0.67068846
73ERBB40.65147736
74CSNK1G30.63819610
75PAK30.62014719
76RIPK40.61235638
77DYRK30.60953646
78GRK10.59028978
79CDK11A0.58961258
80TAOK10.58324113
81CDC42BPA0.57714989
82PRKCH0.57601304
83NME10.56819715
84WNK40.56512706
85CAMK10.55863188
86STK38L0.54552154
87SGK30.53772327
88PRKAA10.53589733
89ADRBK10.52175439
90BMPR20.52167835
91STK110.51749231
92RPS6KA20.51625630
93MAP2K10.50865309
94IRAK10.50520808
95FGR0.50206675
96CAMK40.49829417
97TYRO30.47928270
98CSNK1E0.45760398
99CAMK2G0.43812515
100CDK80.43512075
101OXSR10.42939624
102LATS20.42888746
103RET0.42466240
104PRKCB0.42256106
105MAP3K60.41331834
106ROCK10.40700287
107CAMK1D0.39758792
108RPS6KA30.39657002
109FER0.39608635
110YES10.39582934
111PRKACB0.39397267
112PTK2B0.38851466
113CSNK1G10.37892505
114MAPK90.37629441
115ERBB20.37581088
116CSNK1A10.37511334
117PRKACA0.37109608
118DYRK1B0.36458586
119RPS6KB10.35709542
120FYN0.35214530
121ROCK20.34120375
122STK390.33333777
123TNK20.33017920
124ICK0.32882899
125PRKACG0.31811691
126CSNK1D0.31638671
127CDK190.31342020
128GSK3B0.30010792
129PRKG10.29969486
130TAOK30.29312472
131CDK30.27708528
132MAPK100.26754265

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.22694239
2Synaptic vesicle cycle_Homo sapiens_hsa047213.39070398
3GABAergic synapse_Homo sapiens_hsa047272.90590594
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.84814848
5Olfactory transduction_Homo sapiens_hsa047402.73054791
6Morphine addiction_Homo sapiens_hsa050322.65660281
7Glutamatergic synapse_Homo sapiens_hsa047242.65016114
8Circadian entrainment_Homo sapiens_hsa047132.51762454
9Dopaminergic synapse_Homo sapiens_hsa047282.39816469
10Taste transduction_Homo sapiens_hsa047422.34166236
11Long-term potentiation_Homo sapiens_hsa047202.28687656
12Amphetamine addiction_Homo sapiens_hsa050312.27918290
13Axon guidance_Homo sapiens_hsa043602.11377581
14Collecting duct acid secretion_Homo sapiens_hsa049662.08250578
15Cocaine addiction_Homo sapiens_hsa050302.07780619
16Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.05955791
17Cholinergic synapse_Homo sapiens_hsa047252.03801864
18Serotonergic synapse_Homo sapiens_hsa047261.96528832
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.91695262
20Long-term depression_Homo sapiens_hsa047301.69330702
21Insulin secretion_Homo sapiens_hsa049111.68964248
22Vibrio cholerae infection_Homo sapiens_hsa051101.65500531
23Renin secretion_Homo sapiens_hsa049241.61465430
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.59764222
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.54523702
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.48815074
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.48782686
28Ether lipid metabolism_Homo sapiens_hsa005651.46958371
29Calcium signaling pathway_Homo sapiens_hsa040201.44339392
30Salivary secretion_Homo sapiens_hsa049701.43115587
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.43044005
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42629297
33Gap junction_Homo sapiens_hsa045401.40724329
34Steroid biosynthesis_Homo sapiens_hsa001001.35489778
35Oxytocin signaling pathway_Homo sapiens_hsa049211.32018873
36Gastric acid secretion_Homo sapiens_hsa049711.31986293
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20485022
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.14972766
39Butanoate metabolism_Homo sapiens_hsa006501.12846920
40Oxidative phosphorylation_Homo sapiens_hsa001901.11871421
41Cardiac muscle contraction_Homo sapiens_hsa042601.10535692
42ErbB signaling pathway_Homo sapiens_hsa040121.09473489
43Type I diabetes mellitus_Homo sapiens_hsa049401.08603186
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01512059
45Phototransduction_Homo sapiens_hsa047440.98230350
46GnRH signaling pathway_Homo sapiens_hsa049120.98087101
47cAMP signaling pathway_Homo sapiens_hsa040240.97123498
48Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96153218
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94846254
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93733564
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93157631
52Type II diabetes mellitus_Homo sapiens_hsa049300.92760560
53Melanogenesis_Homo sapiens_hsa049160.91015177
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90297890
55Parkinsons disease_Homo sapiens_hsa050120.89821637
56Alzheimers disease_Homo sapiens_hsa050100.89309086
57ABC transporters_Homo sapiens_hsa020100.84468103
58Glioma_Homo sapiens_hsa052140.84208428
59Circadian rhythm_Homo sapiens_hsa047100.83188597
60Bile secretion_Homo sapiens_hsa049760.82497178
61Estrogen signaling pathway_Homo sapiens_hsa049150.81163990
62Dorso-ventral axis formation_Homo sapiens_hsa043200.80322279
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79528136
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79067208
65Histidine metabolism_Homo sapiens_hsa003400.78596308
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78471420
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77128874
68Linoleic acid metabolism_Homo sapiens_hsa005910.76572616
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75669108
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.73726078
71Alcoholism_Homo sapiens_hsa050340.71826686
72Fatty acid biosynthesis_Homo sapiens_hsa000610.70222234
73Oocyte meiosis_Homo sapiens_hsa041140.67339962
74MAPK signaling pathway_Homo sapiens_hsa040100.64961714
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64911308
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64217249
77Propanoate metabolism_Homo sapiens_hsa006400.63588438
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62515601
79Endometrial cancer_Homo sapiens_hsa052130.62448193
80Dilated cardiomyopathy_Homo sapiens_hsa054140.61713029
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61181555
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60900398
83Complement and coagulation cascades_Homo sapiens_hsa046100.60852641
84Colorectal cancer_Homo sapiens_hsa052100.60790469
85Fatty acid metabolism_Homo sapiens_hsa012120.59868933
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.59199811
87Phagosome_Homo sapiens_hsa041450.58935761
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58657505
89beta-Alanine metabolism_Homo sapiens_hsa004100.56847719
90Huntingtons disease_Homo sapiens_hsa050160.55455398
91Rap1 signaling pathway_Homo sapiens_hsa040150.54765926
92Protein export_Homo sapiens_hsa030600.54531643
93Fat digestion and absorption_Homo sapiens_hsa049750.53945037
94Ras signaling pathway_Homo sapiens_hsa040140.53875268
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53691149
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52816070
97Arginine biosynthesis_Homo sapiens_hsa002200.50741974
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50611413
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50590221
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50161046
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.49532727
102Retinol metabolism_Homo sapiens_hsa008300.48481668
103Tryptophan metabolism_Homo sapiens_hsa003800.46278447
104Choline metabolism in cancer_Homo sapiens_hsa052310.45967425
105Wnt signaling pathway_Homo sapiens_hsa043100.45707149
106Basal transcription factors_Homo sapiens_hsa030220.43162554
107Caffeine metabolism_Homo sapiens_hsa002320.42358839
108Selenocompound metabolism_Homo sapiens_hsa004500.42340757
109Pancreatic secretion_Homo sapiens_hsa049720.41354224
110Fatty acid elongation_Homo sapiens_hsa000620.40655553
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.40318191
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.40113349
113Prion diseases_Homo sapiens_hsa050200.38863656
114Sphingolipid metabolism_Homo sapiens_hsa006000.38243405
115Hedgehog signaling pathway_Homo sapiens_hsa043400.37872541
116Rheumatoid arthritis_Homo sapiens_hsa053230.35299863
117Glucagon signaling pathway_Homo sapiens_hsa049220.34259260
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32983402
119Melanoma_Homo sapiens_hsa052180.32723484
120Insulin signaling pathway_Homo sapiens_hsa049100.32557440
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29583941
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29528758
123Thyroid hormone synthesis_Homo sapiens_hsa049180.28726106
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28324010
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.28054939
126Regulation of autophagy_Homo sapiens_hsa041400.26986923
127Renal cell carcinoma_Homo sapiens_hsa052110.26691596
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25045424
129Maturity onset diabetes of the young_Homo sapiens_hsa049500.22731512
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22486696
131Ovarian steroidogenesis_Homo sapiens_hsa049130.22271409
132mTOR signaling pathway_Homo sapiens_hsa041500.21891022
133Hippo signaling pathway_Homo sapiens_hsa043900.20864505

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