PLPPR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.28277902
2synaptic vesicle maturation (GO:0016188)6.04457935
3locomotory exploration behavior (GO:0035641)5.80336468
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.66679102
5vocalization behavior (GO:0071625)5.58422779
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.55734515
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.52925850
8synaptic vesicle exocytosis (GO:0016079)5.24207466
9glutamate secretion (GO:0014047)5.19037615
10regulation of glutamate receptor signaling pathway (GO:1900449)5.10306346
11protein localization to synapse (GO:0035418)5.00097909
12exploration behavior (GO:0035640)4.85439577
13regulation of synaptic vesicle exocytosis (GO:2000300)4.79990908
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.77600569
15neuron cell-cell adhesion (GO:0007158)4.74629373
16regulation of neuronal synaptic plasticity (GO:0048168)4.65675461
17synaptic vesicle docking involved in exocytosis (GO:0016081)4.62670323
18dendritic spine morphogenesis (GO:0060997)4.56455655
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.55040823
20layer formation in cerebral cortex (GO:0021819)4.52507675
21regulation of synapse structural plasticity (GO:0051823)4.35667728
22regulation of synaptic vesicle transport (GO:1902803)4.30417072
23glutamate receptor signaling pathway (GO:0007215)4.27672762
24synaptic transmission, glutamatergic (GO:0035249)4.24703517
25neurotransmitter secretion (GO:0007269)4.22484244
26neurotransmitter-gated ion channel clustering (GO:0072578)4.15348307
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.09395456
28positive regulation of synapse maturation (GO:0090129)3.99535090
29neuronal action potential propagation (GO:0019227)3.99533459
30neuron recognition (GO:0008038)3.98920774
31proline transport (GO:0015824)3.93557142
32long-term memory (GO:0007616)3.89495779
33positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.87224687
34neuron-neuron synaptic transmission (GO:0007270)3.86898560
35gamma-aminobutyric acid transport (GO:0015812)3.85154121
36regulation of excitatory postsynaptic membrane potential (GO:0060079)3.83959164
37positive regulation of membrane potential (GO:0045838)3.83944602
38cellular potassium ion homeostasis (GO:0030007)3.72514712
39regulation of dendritic spine morphogenesis (GO:0061001)3.71737379
40axonal fasciculation (GO:0007413)3.69547392
41postsynaptic membrane organization (GO:0001941)3.67721395
42regulation of postsynaptic membrane potential (GO:0060078)3.64773831
43regulation of synaptic plasticity (GO:0048167)3.63721891
44regulation of ARF protein signal transduction (GO:0032012)3.55665605
45dendrite morphogenesis (GO:0048813)3.52928913
46negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.48171064
47transmission of nerve impulse (GO:0019226)3.47178478
48sodium ion export (GO:0071436)3.44539535
49dendritic spine organization (GO:0097061)3.44262483
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.41990019
51neurotransmitter transport (GO:0006836)3.40420157
52synaptic vesicle endocytosis (GO:0048488)3.40314435
53cell communication by electrical coupling (GO:0010644)3.38852174
54regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.38401993
55positive regulation of dendritic spine development (GO:0060999)3.38339018
56neuromuscular process controlling balance (GO:0050885)3.37513909
57positive regulation of synaptic transmission, GABAergic (GO:0032230)3.37197866
58auditory behavior (GO:0031223)3.37066705
59innervation (GO:0060384)3.36631941
60positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.36004970
61regulation of vesicle fusion (GO:0031338)3.35075546
62long-term synaptic potentiation (GO:0060291)3.33696478
63gamma-aminobutyric acid signaling pathway (GO:0007214)3.32911378
64establishment of mitochondrion localization (GO:0051654)3.32319563
65activation of protein kinase A activity (GO:0034199)3.31532169
66cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.31404103
67regulation of neurotransmitter secretion (GO:0046928)3.28254329
68positive regulation of dendritic spine morphogenesis (GO:0061003)3.27633279
69regulation of synaptic transmission, glutamatergic (GO:0051966)3.26516584
70G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.25443777
71behavioral defense response (GO:0002209)3.20206798
72behavioral fear response (GO:0001662)3.20206798
73response to auditory stimulus (GO:0010996)3.17706114
74regulation of dendritic spine development (GO:0060998)3.17485076
75pyrimidine nucleobase catabolic process (GO:0006208)3.17444587
76regulation of neurotransmitter levels (GO:0001505)3.16524707
77cerebellar Purkinje cell differentiation (GO:0021702)3.13630174
78G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.13380061
79cell migration in hindbrain (GO:0021535)3.13100850
80presynaptic membrane assembly (GO:0097105)3.12487630
81central nervous system projection neuron axonogenesis (GO:0021952)3.12227565
82negative regulation of synaptic transmission, GABAergic (GO:0032229)3.11089996
83cerebellar Purkinje cell layer development (GO:0021680)3.09646636
84positive regulation of neurotransmitter secretion (GO:0001956)3.09477553
85membrane depolarization (GO:0051899)3.08386580
86learning (GO:0007612)3.07340803
87positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.05667170
88regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.04290369
89regulation of synapse maturation (GO:0090128)3.02525991
90fear response (GO:0042596)3.02361582
91synapse assembly (GO:0007416)3.00182579
92regulation of synaptic transmission (GO:0050804)2.98727019
93regulation of neurotransmitter transport (GO:0051588)2.98337097
94neuronal ion channel clustering (GO:0045161)2.98096383
95vesicle transport along microtubule (GO:0047496)2.94804062
96social behavior (GO:0035176)2.94011190
97intraspecies interaction between organisms (GO:0051703)2.94011190
98neuromuscular process controlling posture (GO:0050884)2.92637668
99membrane hyperpolarization (GO:0060081)2.91689132
100positive regulation of synaptic transmission (GO:0050806)2.91007864
101presynaptic membrane organization (GO:0097090)2.89274800
102response to pheromone (GO:0019236)2.89194317
103negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.88903948
104negative regulation of cell killing (GO:0031342)2.88903948
105cerebellar granule cell differentiation (GO:0021707)2.88834419
106membrane depolarization during action potential (GO:0086010)2.88639422
107negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.88329826
108protein localization to endosome (GO:0036010)2.81942800
109mitochondrion transport along microtubule (GO:0047497)2.78899364
110establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.78899364
111regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.78297953
112positive regulation by symbiont of host defense response (GO:0052509)2.75681730
113modulation by symbiont of host defense response (GO:0052031)2.75681730
114modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.75681730
115modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.75681730
116positive regulation by organism of defense response of other organism involved in symbiotic interact2.75681730
117modulation by symbiont of host immune response (GO:0052553)2.75681730
118cellular response to catecholamine stimulus (GO:0071870)2.68469477
119cellular response to monoamine stimulus (GO:0071868)2.68469477
120adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.63397777
121regulation of ARF GTPase activity (GO:0032312)2.62848657
122regulation of T-helper 2 cell differentiation (GO:0045628)2.61550119
123cell-cell junction maintenance (GO:0045217)2.61191502
124regulation of regulated secretory pathway (GO:1903305)2.56530969
125amino acid import (GO:0043090)2.54466474
126positive regulation of protein dephosphorylation (GO:0035307)2.48737180
127negative regulation of microtubule polymerization (GO:0031115)2.46964463
128axon extension (GO:0048675)2.46263088
129regulation of amyloid precursor protein catabolic process (GO:1902991)2.43487831
130nucleobase catabolic process (GO:0046113)2.40639534
131signal complex assembly (GO:0007172)2.39779310
132neuron projection extension (GO:1990138)2.38435168
133macrophage activation involved in immune response (GO:0002281)2.36080643
134peptidyl-tyrosine autophosphorylation (GO:0038083)2.34887311
135L-amino acid import (GO:0043092)2.32603524
136protein retention in ER lumen (GO:0006621)2.31991656
137cytoskeletal anchoring at plasma membrane (GO:0007016)2.31443120
138positive regulation of fibroblast migration (GO:0010763)2.30620415
139dopamine receptor signaling pathway (GO:0007212)2.29292572
140negative regulation of erythrocyte differentiation (GO:0045647)2.29214852
141response to parathyroid hormone (GO:0071107)2.26933550
142organelle transport along microtubule (GO:0072384)2.26735400
143positive regulation of synapse assembly (GO:0051965)2.26405479
144protein targeting to plasma membrane (GO:0072661)2.25898227
145positive regulation of neurotransmitter transport (GO:0051590)2.25706595
146positive regulation of axon extension (GO:0045773)2.25110637

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.22811402
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.62766112
3GBX2_23144817_ChIP-Seq_PC3_Human3.28405693
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.20933346
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.17600519
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.11797525
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.84346538
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.84346538
9REST_21632747_ChIP-Seq_MESCs_Mouse2.82097676
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.81615722
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.69294893
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.69099526
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.67536417
14RARB_27405468_Chip-Seq_BRAIN_Mouse2.63937715
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.61205773
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.60972036
17LXR_22292898_ChIP-Seq_THP-1_Human2.57713201
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54874573
19DROSHA_22980978_ChIP-Seq_HELA_Human2.52561396
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.44600315
21KDM2B_26808549_Chip-Seq_SUP-B15_Human2.41580452
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.41537045
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.40222446
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.33683722
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.33276434
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.30007449
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.23285440
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.22150299
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.12923236
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.04850267
31KDM2B_26808549_Chip-Seq_DND41_Human2.01181806
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.00755035
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99716644
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.89671137
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.84049578
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78936309
37AR_21572438_ChIP-Seq_LNCaP_Human1.78173868
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.73104209
39VDR_21846776_ChIP-Seq_THP-1_Human1.71634783
40SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.68632124
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.68504160
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68120452
43RACK7_27058665_Chip-Seq_MCF-7_Human1.59598474
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59014671
45ZNF274_21170338_ChIP-Seq_K562_Hela1.58411647
46TCF7_22412390_ChIP-Seq_EML_Mouse1.56093594
47KDM2B_26808549_Chip-Seq_JURKAT_Human1.52927774
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.51891340
49SMC4_20622854_ChIP-Seq_HELA_Human1.51118769
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48923160
51RING1B_27294783_Chip-Seq_ESCs_Mouse1.45555002
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45356945
53SMAD4_21799915_ChIP-Seq_A2780_Human1.44834522
54P68_20966046_ChIP-Seq_HELA_Human1.44082763
55TET1_21451524_ChIP-Seq_MESCs_Mouse1.42381650
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.37135656
57SA1_27219007_Chip-Seq_ERYTHROID_Human1.36785345
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35893681
59SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.35479335
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35166406
61SRY_22984422_ChIP-ChIP_TESTIS_Rat1.34973407
62RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.32857345
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32835252
64UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32363872
65DNAJC2_21179169_ChIP-ChIP_NT2_Human1.32189650
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.28912125
67TAF15_26573619_Chip-Seq_HEK293_Human1.27556583
68NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27396708
69ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26607081
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.25466430
71WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25118895
72CREB1_26743006_Chip-Seq_LNCaP_Human1.24995090
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24531280
74NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24285553
75RING1B_27294783_Chip-Seq_NPCs_Mouse1.23627888
76EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23124004
77ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22150382
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20652503
79ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20006888
80TRIM28_21343339_ChIP-Seq_HEK293_Human1.19166420
81KDM2B_26808549_Chip-Seq_K562_Human1.18283387
82AR_19668381_ChIP-Seq_PC3_Human1.18269283
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.17553530
84WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17252827
85SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16827002
86AR_25329375_ChIP-Seq_VCAP_Human1.16549319
87P300_19829295_ChIP-Seq_ESCs_Human1.15956251
88OCT4_19829295_ChIP-Seq_ESCs_Human1.15367987
89EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14017996
90GATA1_19941827_ChIP-Seq_MEL_Mouse1.13943524
91KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.12546214
92RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10566908
93BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09576803
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09448555
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09162169
96ELF1_20517297_ChIP-Seq_JURKAT_Human1.08646661
97P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08208669
98MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.07262844
99MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06567881
100STAT3_23295773_ChIP-Seq_U87_Human1.06468516
101P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05574651
102VDR_24763502_ChIP-Seq_THP-1_Human1.04811545
103BCL6_27268052_Chip-Seq_Bcells_Human1.04747978
104TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04115598
105RNF2_27304074_Chip-Seq_NSC_Mouse1.03194740
106OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02505456
107TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01711760
108BCOR_27268052_Chip-Seq_Bcells_Human1.01348737
109PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01041156
110RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00893577
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00875638
112YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00038178
113SPI1_23127762_ChIP-Seq_K562_Human0.99761993
114CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99329149
115E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99201828
116KLF4_19829295_ChIP-Seq_ESCs_Human0.98533294
117PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98123971
118ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98081848
119TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97535889
120PIAS1_25552417_ChIP-Seq_VCAP_Human0.96389666
121GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95985909
122CTCF_27219007_Chip-Seq_Bcells_Human0.95747374
123CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95603774
124ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95015873
125RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94946356
126ARNT_22903824_ChIP-Seq_MCF-7_Human0.94677908
127SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.94316353
128TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94084522
129MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94039340
130IGF1R_20145208_ChIP-Seq_DFB_Human0.93818073
131SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.93559494
132VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93091682
133JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.92925616
134PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92472163
135SMAD4_21741376_ChIP-Seq_HESCs_Human0.92006582
136SMAD3_21741376_ChIP-Seq_ESCs_Human0.91989861
137TCF4_23295773_ChIP-Seq_U87_Human0.91786831
138SMC1_22415368_ChIP-Seq_MEFs_Mouse0.91386229
139TP53_20018659_ChIP-ChIP_R1E_Mouse0.91233493
140SA1_27219007_Chip-Seq_Bcells_Human0.90591443
141OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90025872
142TP53_22127205_ChIP-Seq_IMR90_Human0.90004239
143AHR_22903824_ChIP-Seq_MCF-7_Human0.89868935
144NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89526626
145TET1_21490601_ChIP-Seq_MESCs_Mouse0.88575490
146CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88512960
147PRDM14_20953172_ChIP-Seq_ESCs_Human0.87887356
148GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87426661
149ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86220469
150RUNX2_22187159_ChIP-Seq_PCA_Human0.85906405
151SMAD3_21741376_ChIP-Seq_HESCs_Human0.85049213
152SMAD_19615063_ChIP-ChIP_OVARY_Human0.84723063
153TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82489682
154POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.82489682
155JUN_21703547_ChIP-Seq_K562_Human0.81713304
156TP53_16413492_ChIP-PET_HCT116_Human0.81669609

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.06374635
2MP0003880_abnormal_central_pattern4.82323368
3MP0003635_abnormal_synaptic_transmissio4.26642042
4MP0004270_analgesia3.76727870
5MP0002063_abnormal_learning/memory/cond3.45774429
6MP0009745_abnormal_behavioral_response3.41453094
7MP0002064_seizures3.07773023
8MP0005423_abnormal_somatic_nervous2.92847268
9MP0001968_abnormal_touch/_nociception2.84047576
10MP0002572_abnormal_emotion/affect_behav2.80344708
11MP0009046_muscle_twitch2.63216205
12MP0002734_abnormal_mechanical_nocicepti2.57747736
13MP0002822_catalepsy2.50915347
14MP0001486_abnormal_startle_reflex2.45678504
15MP0002272_abnormal_nervous_system2.42111355
16MP0003705_abnormal_hypodermis_morpholog2.32121525
17MP0002736_abnormal_nociception_after2.22224040
18MP0003329_amyloid_beta_deposits2.22180701
19MP0002735_abnormal_chemical_nociception2.21229384
20MP0001440_abnormal_grooming_behavior2.15413788
21MP0000778_abnormal_nervous_system2.14985925
22MP0008260_abnormal_autophagy2.12059632
23MP0009780_abnormal_chondrocyte_physiolo2.11649582
24MP0001501_abnormal_sleep_pattern2.10115116
25MP0004858_abnormal_nervous_system2.05804089
26MP0002733_abnormal_thermal_nociception2.05478153
27MP0002184_abnormal_innervation1.93757218
28MP0001970_abnormal_pain_threshold1.90147471
29MP0004811_abnormal_neuron_physiology1.85284427
30MP0003724_increased_susceptibility_to1.85137483
31MP0001958_emphysema1.83902997
32MP0002067_abnormal_sensory_capabilities1.83278525
33MP0002557_abnormal_social/conspecific_i1.79253177
34MP0008438_abnormal_cutaneous_collagen1.76368125
35MP0003436_decreased_susceptibility_to1.75215649
36MP0002909_abnormal_adrenal_gland1.74509135
37MP0006276_abnormal_autonomic_nervous1.73490844
38MP0008569_lethality_at_weaning1.71169159
39MP0000955_abnormal_spinal_cord1.67314842
40MP0003303_peritoneal_inflammation1.66144342
41MP0004924_abnormal_behavior1.64299334
42MP0005386_behavior/neurological_phenoty1.64299334
43MP0003191_abnormal_cellular_cholesterol1.52751937
44MP0001984_abnormal_olfaction1.51941655
45MP0002882_abnormal_neuron_morphology1.49631050
46MP0003879_abnormal_hair_cell1.49478428
47MP0004885_abnormal_endolymph1.49459719
48MP0001529_abnormal_vocalization1.43782510
49MP0002066_abnormal_motor_capabilities/c1.41772598
50MP0005646_abnormal_pituitary_gland1.36393860
51MP0005645_abnormal_hypothalamus_physiol1.36248884
52MP0001502_abnormal_circadian_rhythm1.34027331
53MP0001905_abnormal_dopamine_level1.31109131
54MP0003123_paternal_imprinting1.29879949
55MP0003787_abnormal_imprinting1.29158285
56MP0003122_maternal_imprinting1.27926752
57MP0003279_aneurysm1.24724060
58MP0003633_abnormal_nervous_system1.22403150
59MP0002152_abnormal_brain_morphology1.21777120
60MP0005058_abnormal_lysosome_morphology1.17563046
61MP0004142_abnormal_muscle_tone1.12984759
62MP0000750_abnormal_muscle_regeneration1.12947293
63MP0002653_abnormal_ependyma_morphology1.11622954
64MP0003631_nervous_system_phenotype1.08656898
65MP0000604_amyloidosis1.01551488
66MP0001542_abnormal_bone_strength1.01532543
67MP0000751_myopathy1.00743093
68MP0002069_abnormal_eating/drinking_beha1.00394492
69MP0001533_abnormal_skeleton_physiology0.99629255
70MP0001348_abnormal_lacrimal_gland0.99354126
71MP0003283_abnormal_digestive_organ0.98621079
72MP0003183_abnormal_peptide_metabolism0.98429130
73MP0005409_darkened_coat_color0.95144882
74MP0010386_abnormal_urinary_bladder0.94225487
75MP0003300_gastrointestinal_ulcer0.92301942
76MP0003634_abnormal_glial_cell0.91107373
77MP0002229_neurodegeneration0.90653645
78MP0008961_abnormal_basal_metabolism0.90307964
79MP0005551_abnormal_eye_electrophysiolog0.88953732
80MP0002249_abnormal_larynx_morphology0.88251480
81MP0003075_altered_response_to0.87387229
82MP0004145_abnormal_muscle_electrophysio0.87238639
83MP0005499_abnormal_olfactory_system0.86741313
84MP0005394_taste/olfaction_phenotype0.86741313
85MP0009278_abnormal_bone_marrow0.86270021
86MP0003632_abnormal_nervous_system0.85559653
87MP0000013_abnormal_adipose_tissue0.85372165
88MP0001177_atelectasis0.85333111
89MP0000631_abnormal_neuroendocrine_gland0.84940651
90MP0001986_abnormal_taste_sensitivity0.84615365
91MP0004130_abnormal_muscle_cell0.84053563
92MP0008872_abnormal_physiological_respon0.82979513
93MP0002837_dystrophic_cardiac_calcinosis0.81806183
94MP0002419_abnormal_innate_immunity0.81645779
95MP0001188_hyperpigmentation0.81144472
96MP0004085_abnormal_heartbeat0.80566847
97MP0000569_abnormal_digit_pigmentation0.80538137
98MP0002752_abnormal_somatic_nervous0.80358019
99MP0000747_muscle_weakness0.78969399
100MP0002295_abnormal_pulmonary_circulatio0.78799989
101MP0004742_abnormal_vestibular_system0.78586516
102MP0005535_abnormal_body_temperature0.77101959
103MP0001963_abnormal_hearing_physiology0.76450516
104MP0003091_abnormal_cell_migration0.76260862
105MP0003566_abnormal_cell_adhesion0.75630862
106MP0008874_decreased_physiological_sensi0.75475280
107MP0002332_abnormal_exercise_endurance0.73555502
108MP0002090_abnormal_vision0.73341472
109MP0005248_abnormal_Harderian_gland0.73099959
110MP0003861_abnormal_nervous_system0.72938836
111MP0000920_abnormal_myelination0.71626320
112MP0003690_abnormal_glial_cell0.70370002
113MP0005451_abnormal_body_composition0.69520666
114MP0005390_skeleton_phenotype0.68338543
115MP0000534_abnormal_ureter_morphology0.67011181
116MP0003121_genomic_imprinting0.65974159
117MP0003137_abnormal_impulse_conducting0.65707315
118MP0002234_abnormal_pharynx_morphology0.65628534
119MP0005623_abnormal_meninges_morphology0.65537731
120MP0005503_abnormal_tendon_morphology0.64685360
121MP0000681_abnormal_thyroid_gland0.64577064
122MP0005187_abnormal_penis_morphology0.63110664
123MP0002638_abnormal_pupillary_reflex0.63069265
124MP0005166_decreased_susceptibility_to0.62516083
125MP0004233_abnormal_muscle_weight0.61739383
126MP0001664_abnormal_digestion0.61651439
127MP0004215_abnormal_myocardial_fiber0.60314539
128MP0004510_myositis0.58729296
129MP0009840_abnormal_foam_cell0.58621583
130MP0003172_abnormal_lysosome_physiology0.57874108
131MP0001299_abnormal_eye_distance/0.56432553
132MP0001943_abnormal_respiration0.55271590
133MP0006072_abnormal_retinal_apoptosis0.54427139
134MP0002876_abnormal_thyroid_physiology0.54007905
135MP0004484_altered_response_of0.53729394
136MP0010769_abnormal_survival0.53704405
137MP0001485_abnormal_pinna_reflex0.51579294
138MP0010770_preweaning_lethality0.51518521

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.03454677
2Myokymia (HP:0002411)6.95184334
3Visual hallucinations (HP:0002367)5.55580670
4Focal seizures (HP:0007359)5.49669840
5Epileptic encephalopathy (HP:0200134)4.60825921
6Progressive cerebellar ataxia (HP:0002073)4.26392423
7Atonic seizures (HP:0010819)4.05147871
8Supranuclear gaze palsy (HP:0000605)4.00831002
9Absence seizures (HP:0002121)3.82888823
10Febrile seizures (HP:0002373)3.81357103
11Generalized tonic-clonic seizures (HP:0002069)3.68012867
12Action tremor (HP:0002345)3.63853269
13Ankle clonus (HP:0011448)3.56597018
14Dialeptic seizures (HP:0011146)3.52446980
15Mutism (HP:0002300)3.44218598
16Impaired vibration sensation in the lower limbs (HP:0002166)3.35125766
17Cerebral inclusion bodies (HP:0100314)3.29279632
18Broad-based gait (HP:0002136)3.28199520
19Poor eye contact (HP:0000817)3.26980383
20Depression (HP:0000716)3.25657301
21Neurofibrillary tangles (HP:0002185)3.24808728
22Abnormality of the lower motor neuron (HP:0002366)3.20602612
23Amblyopia (HP:0000646)3.06242155
24Urinary bladder sphincter dysfunction (HP:0002839)3.04180267
25Dysdiadochokinesis (HP:0002075)3.02925216
26Anxiety (HP:0000739)3.01793880
27Dysmetria (HP:0001310)2.98900865
28Peritonitis (HP:0002586)2.98384793
29Genetic anticipation (HP:0003743)2.96589674
30Impaired social interactions (HP:0000735)2.94981821
31Abnormal social behavior (HP:0012433)2.94981821
32Abnormal eating behavior (HP:0100738)2.94760496
33Truncal ataxia (HP:0002078)2.92966821
34Hemiparesis (HP:0001269)2.91959548
35Papilledema (HP:0001085)2.90199292
36Drooling (HP:0002307)2.88698108
37Excessive salivation (HP:0003781)2.88698108
38Gaze-evoked nystagmus (HP:0000640)2.87137129
39Hyperventilation (HP:0002883)2.85389094
40Torticollis (HP:0000473)2.83370594
41Postural instability (HP:0002172)2.80340727
42Abnormality of binocular vision (HP:0011514)2.69164267
43Diplopia (HP:0000651)2.69164267
44Urinary urgency (HP:0000012)2.68555243
45Spastic gait (HP:0002064)2.68382080
46Focal dystonia (HP:0004373)2.67889758
47Epileptiform EEG discharges (HP:0011182)2.67457409
48Abnormality of the corticospinal tract (HP:0002492)2.66155222
49Hand muscle atrophy (HP:0009130)2.62442833
50Protrusio acetabuli (HP:0003179)2.60226919
51Premature rupture of membranes (HP:0001788)2.60173607
52Distal upper limb amyotrophy (HP:0007149)2.59317140
53Upper limb amyotrophy (HP:0009129)2.59317140
54EEG with generalized epileptiform discharges (HP:0011198)2.57529997
55Peripheral hypomyelination (HP:0007182)2.54166523
56Amyotrophic lateral sclerosis (HP:0007354)2.53664362
57Megalencephaly (HP:0001355)2.52695534
58Impaired smooth pursuit (HP:0007772)2.49906680
59Limb dystonia (HP:0002451)2.48662905
60Hemiplegia (HP:0002301)2.47842739
61Hypsarrhythmia (HP:0002521)2.46612651
62Scanning speech (HP:0002168)2.44878950
63Eczematoid dermatitis (HP:0000976)2.44163327
64Termporal pattern (HP:0011008)2.44143151
65Insidious onset (HP:0003587)2.44143151
66Stereotypic behavior (HP:0000733)2.43722333
67Slender build (HP:0001533)2.42726014
68Polyphagia (HP:0002591)2.41930327
69Bradykinesia (HP:0002067)2.39709339
70Increased variability in muscle fiber diameter (HP:0003557)2.39521665
71Insomnia (HP:0100785)2.38555234
72Genu recurvatum (HP:0002816)2.37405808
73Craniofacial dystonia (HP:0012179)2.36639461
74Intention tremor (HP:0002080)2.35614762
75Progressive inability to walk (HP:0002505)2.34551382
76Lower limb muscle weakness (HP:0007340)2.29694583
77Agitation (HP:0000713)2.26553794
78Amyloidosis (HP:0011034)2.23301760
79Fetal akinesia sequence (HP:0001989)2.22338327
80Absent speech (HP:0001344)2.22270371
81Cerebral aneurysm (HP:0004944)2.21261819
82Abnormality of ocular smooth pursuit (HP:0000617)2.18789018
83Myositis (HP:0100614)2.16709154
84Impaired vibratory sensation (HP:0002495)2.16108834
85Generalized myoclonic seizures (HP:0002123)2.12421717
86Akinesia (HP:0002304)2.11496750
87Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.11359533
88Orchitis (HP:0100796)2.10550802
89Obstructive sleep apnea (HP:0002870)2.09107869
90Abnormality of macrophages (HP:0004311)2.08685086
91Ventricular fibrillation (HP:0001663)2.08643362
92Apathy (HP:0000741)2.06043441
93Pointed chin (HP:0000307)2.05943583
94Episodic fever (HP:0001954)2.05859026
95Hyperacusis (HP:0010780)2.01814203
96Difficulty climbing stairs (HP:0003551)2.00919569
97Delusions (HP:0000746)2.00568613
98Shallow orbits (HP:0000586)2.00140529
99Status epilepticus (HP:0002133)1.98237323
100Hypercortisolism (HP:0001578)1.97025301
101Inability to walk (HP:0002540)1.96096960
102Hypochromic microcytic anemia (HP:0004840)1.95296428
103Pheochromocytoma (HP:0002666)1.92546221
104Incomplete penetrance (HP:0003829)1.92303068
105Abnormality of skeletal muscle fiber size (HP:0012084)1.91443758
106Clonus (HP:0002169)1.91399522
107Mitral regurgitation (HP:0001653)1.89244478
108Long palpebral fissure (HP:0000637)1.88716588
109Rapidly progressive (HP:0003678)1.88154067
110Abnormality of polysaccharide metabolism (HP:0011012)1.87841089
111Abnormality of glycosaminoglycan metabolism (HP:0004371)1.87841089
112Abnormality of mucopolysaccharide metabolism (HP:0011020)1.87841089
113Lower limb amyotrophy (HP:0007210)1.87831511
114Abnormality of salivation (HP:0100755)1.87274595
115Annular pancreas (HP:0001734)1.86311967
116Dysmetric saccades (HP:0000641)1.85817684
117Spinal canal stenosis (HP:0003416)1.85374341
118Neuronal loss in central nervous system (HP:0002529)1.85320648
119Nuclear cataract (HP:0100018)1.85020734
120Gait ataxia (HP:0002066)1.83135578
121Inappropriate behavior (HP:0000719)1.81910390
122Recurrent abscess formation (HP:0002722)1.81807123
123Decreased motor nerve conduction velocity (HP:0003431)1.81667303
124Growth hormone excess (HP:0000845)1.81376417
125Hypoventilation (HP:0002791)1.81363707
126Diminished motivation (HP:0000745)1.80039962
127Increased connective tissue (HP:0009025)1.77780045
128Morphological abnormality of the pyramidal tract (HP:0002062)1.76139247
129Hypoplasia of the brainstem (HP:0002365)1.76017151
130Aplasia/Hypoplasia of the brainstem (HP:0007362)1.76017151
131Broad metatarsal (HP:0001783)1.75994225
132Anosmia (HP:0000458)1.75852283
133Psychosis (HP:0000709)1.74375291
134Sleep apnea (HP:0010535)1.73471194
135Rigidity (HP:0002063)1.73139494
136Retinal dysplasia (HP:0007973)1.70738940
137Dilatation of the ascending aorta (HP:0005111)1.70564542
138Broad face (HP:0000283)1.70155560
139Bladder diverticulum (HP:0000015)1.70111567
140Thin bony cortex (HP:0002753)1.69367011
141Wrist flexion contracture (HP:0001239)1.68746740
142Distal lower limb amyotrophy (HP:0008944)1.68399279
143Cholecystitis (HP:0001082)1.68361375
144Abnormal gallbladder physiology (HP:0012438)1.68361375
145Urinary glycosaminoglycan excretion (HP:0003541)1.67626638
146Mucopolysacchariduria (HP:0008155)1.67626638
147Ankle contracture (HP:0006466)1.67412971
148Dysostosis multiplex (HP:0000943)1.66912883
149Hyperextensible skin (HP:0000974)1.64419120
150Vertebral compression fractures (HP:0002953)1.64137680
151Gastrointestinal infarctions (HP:0005244)1.63684870
152Stridor (HP:0010307)1.61733024

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.48633273
2EPHA44.31087173
3MAP3K94.08352133
4MARK13.96800242
5MINK12.83328936
6MAP3K42.64584758
7TRIB32.53157995
8EPHB12.41645384
9DAPK22.39691365
10PAK62.37024874
11ERN12.22166618
12MAP2K72.19420633
13NTRK22.17970133
14KSR22.15887123
15PRKD32.08482642
16KSR11.97521532
17TESK11.92000462
18TNK21.80768256
19MAP3K111.78532200
20NTRK11.76707668
21SIK11.74905609
22CAMKK11.74782560
23PRKD21.70011787
24MAP2K41.60385867
25CDK51.60188935
26TNIK1.56176569
27MAP3K121.51352493
28ARAF1.51260930
29PRPF4B1.49086607
30SIK21.45839539
31MAPK131.45824046
32PLK21.44984345
33DAPK11.43835163
34RIPK41.42773021
35MAP2K31.39264598
36LATS21.34907813
37GRK51.33609935
38IRAK41.33439088
39CASK1.32439014
40PNCK1.29110340
41UHMK11.28650468
42PRKCG1.24787616
43PHKG21.23344418
44PHKG11.23344418
45STK381.19416685
46TYRO31.19026597
47TESK21.13646673
48MAP3K131.10340868
49MAP3K21.09727225
50FES1.09413507
51CDK191.08463868
52LIMK11.06715294
53MAP3K31.03618018
54PKN21.03204726
55CDK181.02338302
56GRK61.02010393
57DYRK1B1.01341926
58PAK31.00373310
59CDK150.99970971
60MAPK120.99833007
61CAMK2A0.99540543
62CDK140.98114901
63CAMK10.92978371
64TAOK20.92584686
65TAOK10.92336954
66PTK2B0.90645379
67PRKCH0.88778373
68CAMK2B0.88714947
69CDK11A0.87901670
70CAMKK20.86036910
71MARK20.85988503
72RAF10.82807356
73EPHA30.82806758
74DYRK1A0.81447363
75RET0.79752240
76STK110.79616018
77CSNK1G20.76237892
78PTK60.74610253
79BLK0.72694015
80ALK0.70992970
81SGK4940.67072491
82SGK2230.67072491
83PRKG20.64862116
84IRAK20.64834024
85CSK0.64627308
86LMTK20.64551821
87ZAP700.64097518
88PTK20.62129413
89PRKCZ0.61105889
90MAP2K60.60414710
91SGK10.60178783
92HCK0.58931238
93FER0.58684264
94FGR0.58005621
95TYK20.54875497
96NME10.53966750
97MAP3K10.52537519
98OXSR10.52532698
99JAK20.52192162
100PRKD10.50896880
101BMPR20.50852485
102CAMK1G0.50265376
103MAP3K70.50219605
104PRKCE0.49945915
105DYRK20.49193531
106PDGFRA0.48981651
107CAMK2D0.48666112
108PDK10.48447876
109PDPK10.48399650
110FYN0.47938922
111TTN0.47739010
112ERBB30.45909371
113ICK0.45906880
114BRAF0.45610763
115CDC42BPA0.45500088
116MAP4K10.45430385
117PINK10.45382477
118RPS6KA30.44756653
119BCR0.44393805
120MAP2K10.42141390
121CAMK2G0.40661520
122DDR20.40453822
123RIPK10.40198310
124SIK30.40069962
125PKN10.38553113
126RPS6KA20.38502354
127DAPK30.38126774
128MAPK100.37737485
129CAMK40.37726567
130SGK20.36711508
131SGK30.35295197
132WNK30.34934184
133SCYL20.33054901
134ROCK20.31838333
135MAP3K60.31785398

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.73000631
2Synaptic vesicle cycle_Homo sapiens_hsa047213.26743337
3Circadian entrainment_Homo sapiens_hsa047132.74968638
4GABAergic synapse_Homo sapiens_hsa047272.68731861
5Long-term potentiation_Homo sapiens_hsa047202.68291631
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.65165626
7Glutamatergic synapse_Homo sapiens_hsa047242.62166601
8Olfactory transduction_Homo sapiens_hsa047402.61767657
9Amphetamine addiction_Homo sapiens_hsa050312.45356807
10Morphine addiction_Homo sapiens_hsa050322.43013956
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.31467454
12Dopaminergic synapse_Homo sapiens_hsa047282.19230122
13Salivary secretion_Homo sapiens_hsa049702.09655807
14Insulin secretion_Homo sapiens_hsa049112.06139676
15Cholinergic synapse_Homo sapiens_hsa047251.97681948
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.89179170
17Gastric acid secretion_Homo sapiens_hsa049711.84378067
18Taste transduction_Homo sapiens_hsa047421.71705147
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68435520
20Long-term depression_Homo sapiens_hsa047301.67924524
21Cocaine addiction_Homo sapiens_hsa050301.67908517
22Oxytocin signaling pathway_Homo sapiens_hsa049211.67736128
23Serotonergic synapse_Homo sapiens_hsa047261.65798520
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.65364191
25Renin secretion_Homo sapiens_hsa049241.59407200
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.57196423
27Calcium signaling pathway_Homo sapiens_hsa040201.54803214
28GnRH signaling pathway_Homo sapiens_hsa049121.48045332
29Axon guidance_Homo sapiens_hsa043601.40856197
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38631883
31Gap junction_Homo sapiens_hsa045401.37521775
32Collecting duct acid secretion_Homo sapiens_hsa049661.35964512
33cAMP signaling pathway_Homo sapiens_hsa040241.23943585
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23810773
35Type II diabetes mellitus_Homo sapiens_hsa049301.21141193
36Osteoclast differentiation_Homo sapiens_hsa043801.20692443
37Glioma_Homo sapiens_hsa052141.19838090
38Estrogen signaling pathway_Homo sapiens_hsa049151.19590392
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.18641857
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15844047
41Melanogenesis_Homo sapiens_hsa049161.12185402
42ErbB signaling pathway_Homo sapiens_hsa040121.07037013
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04471469
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02099371
45Acute myeloid leukemia_Homo sapiens_hsa052211.01662047
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01476030
47Phagosome_Homo sapiens_hsa041451.01428814
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00962241
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99424548
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99247859
51Glycosaminoglycan degradation_Homo sapiens_hsa005310.98705147
52Vibrio cholerae infection_Homo sapiens_hsa051100.98312097
53Cardiac muscle contraction_Homo sapiens_hsa042600.97267003
54Notch signaling pathway_Homo sapiens_hsa043300.93832122
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91795542
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89322653
57Salmonella infection_Homo sapiens_hsa051320.88666430
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87984559
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.87963616
60Tuberculosis_Homo sapiens_hsa051520.85978646
61Oocyte meiosis_Homo sapiens_hsa041140.85287184
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.84744903
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81453384
64Pancreatic secretion_Homo sapiens_hsa049720.77324227
65Choline metabolism in cancer_Homo sapiens_hsa052310.76431610
66Thyroid hormone synthesis_Homo sapiens_hsa049180.76198351
67Dorso-ventral axis formation_Homo sapiens_hsa043200.75703423
68AMPK signaling pathway_Homo sapiens_hsa041520.74993863
69Amoebiasis_Homo sapiens_hsa051460.73421473
70Dilated cardiomyopathy_Homo sapiens_hsa054140.72443209
71Chronic myeloid leukemia_Homo sapiens_hsa052200.72358568
72Phototransduction_Homo sapiens_hsa047440.71763661
73Prolactin signaling pathway_Homo sapiens_hsa049170.71685751
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71683360
75VEGF signaling pathway_Homo sapiens_hsa043700.70987229
76B cell receptor signaling pathway_Homo sapiens_hsa046620.70127911
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69870078
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69546977
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69258675
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69185311
81Nitrogen metabolism_Homo sapiens_hsa009100.69011211
82Shigellosis_Homo sapiens_hsa051310.68535705
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67489271
84Lysosome_Homo sapiens_hsa041420.67132777
85MAPK signaling pathway_Homo sapiens_hsa040100.67112703
86Other glycan degradation_Homo sapiens_hsa005110.66616246
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.66593460
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66344871
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.64501371
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63286585
91Focal adhesion_Homo sapiens_hsa045100.61178475
92Glucagon signaling pathway_Homo sapiens_hsa049220.60947385
93Ras signaling pathway_Homo sapiens_hsa040140.58800273
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58596720
95Pancreatic cancer_Homo sapiens_hsa052120.56272967
96Prion diseases_Homo sapiens_hsa050200.56257827
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55216930
98Malaria_Homo sapiens_hsa051440.53678102
99Rap1 signaling pathway_Homo sapiens_hsa040150.53232988
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52796775
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.52159840
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51559366
103Bile secretion_Homo sapiens_hsa049760.51481205
104Endometrial cancer_Homo sapiens_hsa052130.51272007
105Platelet activation_Homo sapiens_hsa046110.51047720
106Alcoholism_Homo sapiens_hsa050340.50852508
107Wnt signaling pathway_Homo sapiens_hsa043100.49950293
108mTOR signaling pathway_Homo sapiens_hsa041500.49140118
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47563663
110Endocytosis_Homo sapiens_hsa041440.47462032
111Renal cell carcinoma_Homo sapiens_hsa052110.46973717
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44305379
113Non-small cell lung cancer_Homo sapiens_hsa052230.43189076
114Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43003002
115Insulin signaling pathway_Homo sapiens_hsa049100.40153676
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38035208
117Type I diabetes mellitus_Homo sapiens_hsa049400.37804012
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36662676
119Circadian rhythm_Homo sapiens_hsa047100.35709473
120Inositol phosphate metabolism_Homo sapiens_hsa005620.35231059
121Alzheimers disease_Homo sapiens_hsa050100.33718986
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32272572
123Ovarian steroidogenesis_Homo sapiens_hsa049130.31685496
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31299801
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31158738
126Colorectal cancer_Homo sapiens_hsa052100.30907526
127Butanoate metabolism_Homo sapiens_hsa006500.26993218
128African trypanosomiasis_Homo sapiens_hsa051430.26208965
129Chemokine signaling pathway_Homo sapiens_hsa040620.25165586
130Hedgehog signaling pathway_Homo sapiens_hsa043400.23037186
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.22052874

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