PLPPR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The proteins in the lipid phosphate phosphatase (LPP) family, including PRG2, are integral membrane proteins that modulate bioactive lipid phosphates including phosphatidate, lysophosphatidate, and sphingosine-1-phosphate in the context of cell migration, neurite retraction, and mitogenesis (Brauer et al., 2003 [PubMed 12730698]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)8.46067320
2nucleobase catabolic process (GO:0046113)6.70228836
3response to pheromone (GO:0019236)6.16794666
4layer formation in cerebral cortex (GO:0021819)5.78532785
5axonal fasciculation (GO:0007413)5.70231815
6cell migration in hindbrain (GO:0021535)5.19703287
7axonemal dynein complex assembly (GO:0070286)5.11997868
8central nervous system projection neuron axonogenesis (GO:0021952)5.06951244
9neuron recognition (GO:0008038)5.01499962
10negative regulation of microtubule polymerization (GO:0031115)4.87573316
11neuronal ion channel clustering (GO:0045161)4.87417046
12neuron cell-cell adhesion (GO:0007158)4.84619773
13dendritic spine morphogenesis (GO:0060997)4.80741331
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.59177371
15planar cell polarity pathway involved in neural tube closure (GO:0090179)4.48734080
16synaptic vesicle maturation (GO:0016188)4.45099864
17regulation of short-term neuronal synaptic plasticity (GO:0048172)4.40593305
18protein localization to synapse (GO:0035418)4.33684564
19regulation of synapse structural plasticity (GO:0051823)4.29733695
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.22142396
21positive regulation of synapse maturation (GO:0090129)4.21349986
22presynaptic membrane assembly (GO:0097105)4.20083369
23locomotory exploration behavior (GO:0035641)4.09990982
24vocalization behavior (GO:0071625)4.08790172
25regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.07568974
26negative regulation of catenin import into nucleus (GO:0035414)4.01395315
27cilium or flagellum-dependent cell motility (GO:0001539)3.94318779
28exploration behavior (GO:0035640)3.93682491
29left/right pattern formation (GO:0060972)3.93552992
30regulation of glutamate receptor signaling pathway (GO:1900449)3.91112649
31positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.87232434
32positive regulation of dendritic spine morphogenesis (GO:0061003)3.82204746
33cerebral cortex neuron differentiation (GO:0021895)3.80067567
34dendrite morphogenesis (GO:0048813)3.78409916
35central nervous system neuron axonogenesis (GO:0021955)3.76384636
36postsynaptic membrane organization (GO:0001941)3.72551824
37cilium movement (GO:0003341)3.71894838
38forebrain neuron differentiation (GO:0021879)3.71457028
39synaptic vesicle exocytosis (GO:0016079)3.68444232
40protein-DNA complex disassembly (GO:0032986)3.67368671
41nucleosome disassembly (GO:0006337)3.67368671
42establishment of nucleus localization (GO:0040023)3.66484895
43substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.64748084
44substrate-independent telencephalic tangential migration (GO:0021826)3.64748084
45spinal cord development (GO:0021510)3.62415547
46motile cilium assembly (GO:0044458)3.60667108
47dosage compensation (GO:0007549)3.59337749
48cerebellar Purkinje cell layer development (GO:0021680)3.57366437
49generation of neurons (GO:0048699)3.56601516
50cranial nerve morphogenesis (GO:0021602)3.52618108
51auditory behavior (GO:0031223)3.52113390
52regulation of neuronal synaptic plasticity (GO:0048168)3.51967492
53presynaptic membrane organization (GO:0097090)3.51635797
54synaptic vesicle docking involved in exocytosis (GO:0016081)3.51247499
55regulation of synaptic vesicle exocytosis (GO:2000300)3.50553307
56positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.49953497
57convergent extension (GO:0060026)3.49769309
58apical protein localization (GO:0045176)3.47543083
59cerebellar Purkinje cell differentiation (GO:0021702)3.46789948
60positive regulation of dendritic spine development (GO:0060999)3.43718798
61hippocampus development (GO:0021766)3.41879565
62establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.39427521
63mitochondrion transport along microtubule (GO:0047497)3.39427521
64lateral sprouting from an epithelium (GO:0060601)3.38910552
65semaphorin-plexin signaling pathway (GO:0071526)3.38801408
66epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.36936852
67cerebellum development (GO:0021549)3.35369013
68neuron migration (GO:0001764)3.33785708
69peptidyl-arginine omega-N-methylation (GO:0035247)3.32706967
70negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.32073161
71positive regulation of synapse assembly (GO:0051965)3.31050496
72axon extension (GO:0048675)3.28540419
73clathrin coat assembly (GO:0048268)3.27573439
74glutamate secretion (GO:0014047)3.27373203
75camera-type eye morphogenesis (GO:0048593)3.27148635
76mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.25057089
77peptidyl-arginine N-methylation (GO:0035246)3.21744095
78peptidyl-arginine methylation (GO:0018216)3.21744095
79negative regulation of RNA splicing (GO:0033119)3.20578447
80establishment or maintenance of monopolar cell polarity (GO:0061339)3.19214781
81establishment of monopolar cell polarity (GO:0061162)3.19214781
82establishment of mitochondrion localization (GO:0051654)3.17749891
83regulation of synapse assembly (GO:0051963)3.16489985
84regulation of synapse organization (GO:0050807)3.14663171
85regulation of synaptic vesicle transport (GO:1902803)3.14315027
86epithelial cilium movement (GO:0003351)3.14297795
87regulation of axon extension (GO:0030516)3.13614704
88regulation of synapse maturation (GO:0090128)3.12713699
89neurotransmitter secretion (GO:0007269)3.09881176
90cell-cell junction maintenance (GO:0045217)3.07822529
91positive regulation of synaptic transmission, GABAergic (GO:0032230)3.07426665
92establishment or maintenance of bipolar cell polarity (GO:0061245)3.07097863
93establishment or maintenance of apical/basal cell polarity (GO:0035088)3.07097863
94axon extension involved in axon guidance (GO:0048846)3.06711598
95neuron projection extension involved in neuron projection guidance (GO:1902284)3.06711598
96regulation of long-term neuronal synaptic plasticity (GO:0048169)3.01983618
97regulation of NFAT protein import into nucleus (GO:0051532)3.01903742
98response to auditory stimulus (GO:0010996)2.99963239
99regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.99293016
100dopamine receptor signaling pathway (GO:0007212)2.99170054
101synaptic transmission, glutamatergic (GO:0035249)2.98720819
102negative regulation of axon extension (GO:0030517)2.96727020
103G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.96157592
104ionotropic glutamate receptor signaling pathway (GO:0035235)2.96153216
105neuron projection extension (GO:1990138)2.96095753
106proline transport (GO:0015824)2.95758542
107positive regulation of dendrite morphogenesis (GO:0050775)2.95747179
108neuromuscular process controlling balance (GO:0050885)2.95017809
109regulation of microtubule polymerization (GO:0031113)2.94725200
110Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.94580353
111mechanosensory behavior (GO:0007638)2.92279366
112establishment of apical/basal cell polarity (GO:0035089)2.91233052
113adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.90630173
114paraxial mesoderm development (GO:0048339)2.89572421
115glutamate receptor signaling pathway (GO:0007215)2.88726499
116axon cargo transport (GO:0008088)2.87512678
117establishment of planar polarity (GO:0001736)2.85868103
118establishment of tissue polarity (GO:0007164)2.85868103
119mating behavior (GO:0007617)2.84263543
120positive regulation of dendrite development (GO:1900006)2.82615570
121positive regulation of filopodium assembly (GO:0051491)2.82367131
122negative regulation of axon guidance (GO:1902668)2.82303957
123cerebellar granule cell differentiation (GO:0021707)2.82201937
124regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.81473882
125negative regulation of axonogenesis (GO:0050771)2.81056419
126negative regulation of organelle assembly (GO:1902116)2.80502489
127regulation of respiratory system process (GO:0044065)2.80413134
128regulation of extent of cell growth (GO:0061387)2.79403894
129regulation of dendritic spine morphogenesis (GO:0061001)2.78580779
130establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.76840965
131regulation of establishment of planar polarity (GO:0090175)2.76225668
132spinal cord association neuron differentiation (GO:0021527)2.75328704
133regulation of axonogenesis (GO:0050770)2.75286070
134body morphogenesis (GO:0010171)2.74940473
135regulation of dendrite development (GO:0050773)2.74507121
136suckling behavior (GO:0001967)2.73550026
137dendritic spine organization (GO:0097061)2.72891135
138asymmetric protein localization (GO:0008105)2.72868469
139cerebral cortex radially oriented cell migration (GO:0021799)2.72703579
140transmission of nerve impulse (GO:0019226)2.72449450
141synapse assembly (GO:0007416)2.70028416
142microtubule bundle formation (GO:0001578)2.66488661
143neuronal stem cell maintenance (GO:0097150)2.65755534
144lens fiber cell development (GO:0070307)2.62900059

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.76246656
2CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.89579589
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.60749431
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.13194107
5EZH2_27304074_Chip-Seq_ESCs_Mouse3.00232548
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.95878515
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.82966570
8SUZ12_27294783_Chip-Seq_ESCs_Mouse2.64709664
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64551762
10MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.62537706
11EZH2_27294783_Chip-Seq_ESCs_Mouse2.60137342
12REST_21632747_ChIP-Seq_MESCs_Mouse2.58806056
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.54379510
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.53402572
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.53402572
16ZFP281_18757296_ChIP-ChIP_E14_Mouse2.50547872
17IKZF1_21737484_ChIP-ChIP_HCT116_Human2.49647155
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.43453193
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.35673727
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.32159802
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.22541744
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.19010902
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.13208827
24IGF1R_20145208_ChIP-Seq_DFB_Human2.05460498
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.05268060
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.05008517
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01968437
28PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.01628332
29DROSHA_22980978_ChIP-Seq_HELA_Human2.00053914
30OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.97233021
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.93778916
32MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92607748
33RING1B_27294783_Chip-Seq_ESCs_Mouse1.88218139
34MYC_22102868_ChIP-Seq_BL_Human1.85031830
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82645932
36ZFP281_27345836_Chip-Seq_ESCs_Mouse1.77878748
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.75389014
38WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.73423930
39DNAJC2_21179169_ChIP-ChIP_NT2_Human1.71634436
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.70749387
41KDM2B_26808549_Chip-Seq_K562_Human1.68286662
42CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.65933662
43RING1B_27294783_Chip-Seq_NPCs_Mouse1.65883019
44EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.62363966
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.60954686
46VDR_21846776_ChIP-Seq_THP-1_Human1.60951918
47GATA1_26923725_Chip-Seq_HPCs_Mouse1.56192381
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.55475812
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.55425535
50GBX2_23144817_ChIP-Seq_PC3_Human1.53956772
51SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.52711681
52ZNF274_21170338_ChIP-Seq_K562_Hela1.50030306
53EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.49320975
54LXR_22292898_ChIP-Seq_THP-1_Human1.49306197
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.49233390
56RNF2_27304074_Chip-Seq_NSC_Mouse1.47856267
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47284233
58KDM2B_26808549_Chip-Seq_DND41_Human1.43518028
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.41152057
60CIITA_25753668_ChIP-Seq_RAJI_Human1.38980953
61DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.38456537
62RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.37321889
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36747216
64CREB1_26743006_Chip-Seq_LNCaP_Human1.32446140
65KDM2B_26808549_Chip-Seq_JURKAT_Human1.30050552
66RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.28326665
67TP53_20018659_ChIP-ChIP_R1E_Mouse1.24713826
68SCL_19346495_ChIP-Seq_HPC-7_Human1.23877713
69TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23577103
70SMC4_20622854_ChIP-Seq_HELA_Human1.21949418
71TCF7_22412390_ChIP-Seq_EML_Mouse1.20740542
72CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.18831027
73AR_21572438_ChIP-Seq_LNCaP_Human1.18774061
74CTCF_27219007_Chip-Seq_Bcells_Human1.17247466
75HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.13654577
76POU5F1_16518401_ChIP-PET_MESCs_Mouse1.12021141
77KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11811561
78SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10485879
79SA1_27219007_Chip-Seq_ERYTHROID_Human1.09205353
80ISL1_27105846_Chip-Seq_CPCs_Mouse1.06984923
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06384186
82THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04150942
83SOX3_22085726_ChIP-Seq_NPCs_Mouse1.03719189
84NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03485579
85TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03001485
86SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02087747
87MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.00743228
88TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00645487
89KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00007414
90CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98987987
91TET1_21451524_ChIP-Seq_MESCs_Mouse0.98064325
92CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97077511
93SOX2_16153702_ChIP-ChIP_HESCs_Human0.95628770
94SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95337242
95POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95228731
96POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94420467
97SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92675691
98P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91832492
99PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91775588
100WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91097025
101SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.90851038
102TET1_21490601_ChIP-Seq_MESCs_Mouse0.90818720
103KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.89795020
104GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89510414
105NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.89298870
106SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.88862721
107VDR_24763502_ChIP-Seq_THP-1_Human0.87711905
108SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87179906
109SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87044063
110MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.86394472
111STAT6_21828071_ChIP-Seq_BEAS2B_Human0.85799326
112DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85735664
113NANOG_21062744_ChIP-ChIP_HESCs_Human0.85621279
114NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.85071332
115VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84575442
116AR_19668381_ChIP-Seq_PC3_Human0.81054136
117P68_20966046_ChIP-Seq_HELA_Human0.80993112
118CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.80943469
119TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.80261364
120HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.79877682
121CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.79586318
122UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.78957318
123YAP1_20516196_ChIP-Seq_MESCs_Mouse0.78519358
124CTCF_18555785_ChIP-Seq_MESCs_Mouse0.78393836
125EGR1_19374776_ChIP-ChIP_THP-1_Human0.77362782
126TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.77289230

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.92800978
2MP0005423_abnormal_somatic_nervous4.81856933
3MP0003880_abnormal_central_pattern3.64311366
4MP0000778_abnormal_nervous_system3.34662665
5MP0003122_maternal_imprinting3.07025415
6MP0003635_abnormal_synaptic_transmissio3.05875109
7MP0006276_abnormal_autonomic_nervous2.97757427
8MP0002063_abnormal_learning/memory/cond2.80744486
9MP0000566_synostosis2.71441468
10MP0004270_analgesia2.68963682
11MP0005645_abnormal_hypothalamus_physiol2.51311630
12MP0000569_abnormal_digit_pigmentation2.28947050
13MP0002184_abnormal_innervation2.26368792
14MP0004133_heterotaxia2.23832215
15MP0004811_abnormal_neuron_physiology2.15386336
16MP0009745_abnormal_behavioral_response2.07844554
17MP0002572_abnormal_emotion/affect_behav2.03582023
18MP0002733_abnormal_thermal_nociception2.03565421
19MP0008995_early_reproductive_senescence2.00292340
20MP0001529_abnormal_vocalization1.98831058
21MP0001984_abnormal_olfaction1.97949521
22MP0001486_abnormal_startle_reflex1.97294989
23MP0003121_genomic_imprinting1.96739119
24MP0002734_abnormal_mechanical_nocicepti1.91804549
25MP0000955_abnormal_spinal_cord1.91785670
26MP0002557_abnormal_social/conspecific_i1.83993815
27MP0002064_seizures1.83887221
28MP0001968_abnormal_touch/_nociception1.75111525
29MP0000631_abnormal_neuroendocrine_gland1.69926473
30MP0002102_abnormal_ear_morphology1.65644344
31MP0001970_abnormal_pain_threshold1.64358608
32MP0002653_abnormal_ependyma_morphology1.58565987
33MP0000537_abnormal_urethra_morphology1.58094406
34MP0002882_abnormal_neuron_morphology1.56499168
35MP0008961_abnormal_basal_metabolism1.53542603
36MP0003123_paternal_imprinting1.52573284
37MP0002735_abnormal_chemical_nociception1.51312562
38MP0002938_white_spotting1.49378030
39MP0002152_abnormal_brain_morphology1.46671150
40MP0001440_abnormal_grooming_behavior1.45685176
41MP0002249_abnormal_larynx_morphology1.44567571
42MP0001502_abnormal_circadian_rhythm1.44011089
43MP0002751_abnormal_autonomic_nervous1.43359126
44MP0003183_abnormal_peptide_metabolism1.41709592
45MP0003861_abnormal_nervous_system1.40737341
46MP0009046_muscle_twitch1.40097849
47MP0005386_behavior/neurological_phenoty1.36757907
48MP0004924_abnormal_behavior1.36757907
49MP0003787_abnormal_imprinting1.33120775
50MP0004858_abnormal_nervous_system1.33048082
51MP0005076_abnormal_cell_differentiation1.28504023
52MP0002067_abnormal_sensory_capabilities1.28478613
53MP0009672_abnormal_birth_weight1.28045183
54MP0003878_abnormal_ear_physiology1.27986476
55MP0005377_hearing/vestibular/ear_phenot1.27986476
56MP0002234_abnormal_pharynx_morphology1.26346604
57MP0009278_abnormal_bone_marrow1.23936904
58MP0005174_abnormal_tail_pigmentation1.22721661
59MP0003136_yellow_coat_color1.21601446
60MP0002272_abnormal_nervous_system1.21288021
61MP0001293_anophthalmia1.19175443
62MP0005499_abnormal_olfactory_system1.18840553
63MP0005394_taste/olfaction_phenotype1.18840553
64MP0001299_abnormal_eye_distance/1.18571434
65MP0002066_abnormal_motor_capabilities/c1.15491618
66MP0002233_abnormal_nose_morphology1.15181835
67MP0002909_abnormal_adrenal_gland1.15009098
68MP0008569_lethality_at_weaning1.14334783
69MP0005187_abnormal_penis_morphology1.11882369
70MP0001346_abnormal_lacrimal_gland1.11441288
71MP0009379_abnormal_foot_pigmentation1.10169314
72MP0003879_abnormal_hair_cell1.09588447
73MP0003937_abnormal_limbs/digits/tail_de1.09495761
74MP0002396_abnormal_hematopoietic_system1.08540483
75MP0008789_abnormal_olfactory_epithelium1.07790144
76MP0003172_abnormal_lysosome_physiology1.06271681
77MP0002697_abnormal_eye_size1.05029131
78MP0002822_catalepsy1.04559100
79MP0004885_abnormal_endolymph1.04303438
80MP0000428_abnormal_craniofacial_morphol1.04003475
81MP0002116_abnormal_craniofacial_bone1.03797342
82MP0003119_abnormal_digestive_system1.02918474
83MP0006292_abnormal_olfactory_placode1.01736996
84MP0002089_abnormal_postnatal_growth/wei1.01316231
85MP0003634_abnormal_glial_cell1.00380899
86MP0000026_abnormal_inner_ear1.00034749
87MP0009053_abnormal_anal_canal0.99883937
88MP0002081_perinatal_lethality0.97805388
89MP0002638_abnormal_pupillary_reflex0.97383345
90MP0003315_abnormal_perineum_morphology0.96865421
91MP0003329_amyloid_beta_deposits0.96856717
92MP0002069_abnormal_eating/drinking_beha0.96049602
93MP0002092_abnormal_eye_morphology0.96041888
94MP0000013_abnormal_adipose_tissue0.95409078
95MP0004742_abnormal_vestibular_system0.95243591
96MP0005646_abnormal_pituitary_gland0.92355902
97MP0002752_abnormal_somatic_nervous0.91968361
98MP0010030_abnormal_orbit_morphology0.91709320
99MP0001177_atelectasis0.91600837
100MP0002736_abnormal_nociception_after0.91380347
101MP0009703_decreased_birth_body0.91255136
102MP0003942_abnormal_urinary_system0.90661802
103MP0005248_abnormal_Harderian_gland0.90485685
104MP0002084_abnormal_developmental_patter0.90431089
105MP0003115_abnormal_respiratory_system0.89295432
106MP0002282_abnormal_trachea_morphology0.85580962
107MP0002085_abnormal_embryonic_tissue0.84119007
108MP0003890_abnormal_embryonic-extraembry0.83395310
109MP0000462_abnormal_digestive_system0.82731303
110MP0001849_ear_inflammation0.80299369
111MP0001348_abnormal_lacrimal_gland0.78266601
112MP0003385_abnormal_body_wall0.77778942
113MP0002111_abnormal_tail_morphology0.77088000
114MP0005409_darkened_coat_color0.76924018
115MP0001501_abnormal_sleep_pattern0.76424680
116MP0010770_preweaning_lethality0.76251818
117MP0002082_postnatal_lethality0.76251818
118MP0001905_abnormal_dopamine_level0.76250146
119MP0010769_abnormal_survival0.73695420
120MP0003283_abnormal_digestive_organ0.72414056
121MP0004142_abnormal_muscle_tone0.72273634
122MP0010768_mortality/aging0.72047184
123MP0009780_abnormal_chondrocyte_physiolo0.71587922
124MP0003303_peritoneal_inflammation0.71437970
125MP0000534_abnormal_ureter_morphology0.70733812
126MP0001943_abnormal_respiration0.70348391
127MP0000681_abnormal_thyroid_gland0.68716842
128MP0003938_abnormal_ear_development0.68699670
129MP0004134_abnormal_chest_morphology0.67932822
130MP0001188_hyperpigmentation0.67248276
131MP0000751_myopathy0.65338407
132MP0000049_abnormal_middle_ear0.62747200

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.15465030
2Abnormal respiratory motile cilium morphology (HP:0005938)4.54864583
3Abnormal respiratory epithelium morphology (HP:0012253)4.54864583
4Hyperacusis (HP:0010780)4.54595010
5Failure to thrive in infancy (HP:0001531)4.28329663
6Polyphagia (HP:0002591)4.26471329
7Abnormal respiratory motile cilium physiology (HP:0012261)4.19502649
8Dynein arm defect of respiratory motile cilia (HP:0012255)4.14961473
9Absent/shortened dynein arms (HP:0200106)4.14961473
10Abnormal ciliary motility (HP:0012262)4.01208569
11Elfin facies (HP:0004428)3.99545103
12Turricephaly (HP:0000262)3.83591774
13Myokymia (HP:0002411)3.80422380
14Rhinitis (HP:0012384)3.80272845
15Abnormal eating behavior (HP:0100738)3.74900293
16Insomnia (HP:0100785)3.65982851
17Mutism (HP:0002300)3.57558272
18Vitreoretinal degeneration (HP:0000655)3.54174660
19Overriding aorta (HP:0002623)3.43460270
20Limb dystonia (HP:0002451)3.42404683
21Renal duplication (HP:0000075)3.36131097
22Papilledema (HP:0001085)3.25653937
23Ankle clonus (HP:0011448)3.25308928
24Renovascular hypertension (HP:0100817)3.24857050
25Supranuclear gaze palsy (HP:0000605)3.24646452
26Visual hallucinations (HP:0002367)3.22662285
27Focal seizures (HP:0007359)3.17233045
28Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.10827145
29Chronic bronchitis (HP:0004469)3.02697488
30Lissencephaly (HP:0001339)3.01430189
31Amyotrophic lateral sclerosis (HP:0007354)2.99802458
32Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.96977266
33Short 4th metacarpal (HP:0010044)2.96977266
34Flat cornea (HP:0007720)2.92791890
35Focal motor seizures (HP:0011153)2.91758245
36Poor eye contact (HP:0000817)2.88415584
37Broad-based gait (HP:0002136)2.74494843
38Pointed chin (HP:0000307)2.70390766
39Sleep apnea (HP:0010535)2.70216943
40Hypoplasia of the brainstem (HP:0002365)2.68684963
41Aplasia/Hypoplasia of the brainstem (HP:0007362)2.68684963
42Sacral dimple (HP:0000960)2.67146821
43Diminished motivation (HP:0000745)2.55140803
44Apathy (HP:0000741)2.53709983
45Large eyes (HP:0001090)2.52657254
46Atelectasis (HP:0100750)2.51189413
47Stereotypic behavior (HP:0000733)2.50113533
48Trigonocephaly (HP:0000243)2.47523292
49Urinary urgency (HP:0000012)2.47333301
50Poikiloderma (HP:0001029)2.43978549
51Cutaneous finger syndactyly (HP:0010554)2.43298165
52Cutaneous syndactyly (HP:0012725)2.42787771
53Esotropia (HP:0000565)2.41432545
54Tented upper lip vermilion (HP:0010804)2.40835034
55Pachygyria (HP:0001302)2.40525460
56High anterior hairline (HP:0009890)2.38177752
57Megalocornea (HP:0000485)2.37856949
58Impaired social interactions (HP:0000735)2.36934581
59Abnormal social behavior (HP:0012433)2.36934581
60Hepatoblastoma (HP:0002884)2.35018629
61Epileptic encephalopathy (HP:0200134)2.33879193
62Cortical dysplasia (HP:0002539)2.33382762
63Coronal craniosynostosis (HP:0004440)2.32948477
64Choanal stenosis (HP:0000452)2.28907278
65Aplasia involving bones of the upper limbs (HP:0009823)2.26930227
66Aplasia of the phalanges of the hand (HP:0009802)2.26930227
67Aplasia involving bones of the extremities (HP:0009825)2.26930227
68Torticollis (HP:0000473)2.25852912
69Annular pancreas (HP:0001734)2.25783611
70Generalized hypotonia (HP:0001290)2.24123632
71Inappropriate behavior (HP:0000719)2.23582754
72Abnormality of the metopic suture (HP:0005556)2.23452474
73Rib fusion (HP:0000902)2.22551793
74Abnormality of the aortic arch (HP:0012303)2.20860238
75Abnormality of the diencephalon (HP:0010662)2.19416282
76Nasal polyposis (HP:0100582)2.18928964
77Drooling (HP:0002307)2.15735505
78Excessive salivation (HP:0003781)2.15735505
79Increased nuchal translucency (HP:0010880)2.15462422
80Obsessive-compulsive behavior (HP:0000722)2.15270992
81Open mouth (HP:0000194)2.14887406
82Spastic gait (HP:0002064)2.14564003
83Akinesia (HP:0002304)2.13634643
84Broad distal phalanx of finger (HP:0009836)2.11567512
85Prominent metopic ridge (HP:0005487)2.11319670
86Bronchiectasis (HP:0002110)2.09837238
87Autism (HP:0000717)2.09522250
88Protruding tongue (HP:0010808)2.06045229
89Progressive inability to walk (HP:0002505)2.05141688
90Hypoventilation (HP:0002791)2.04367376
91Acute lymphatic leukemia (HP:0006721)2.04287462
92Bronchomalacia (HP:0002780)2.04229103
93Entropion (HP:0000621)2.03391001
94Focal dystonia (HP:0004373)2.02996029
95Septo-optic dysplasia (HP:0100842)2.02220769
96Abnormality of the 4th metacarpal (HP:0010012)2.01708892
97Depression (HP:0000716)2.01057407
98Precocious puberty (HP:0000826)2.00342592
99Fetal akinesia sequence (HP:0001989)1.99953925
100Atrophy/Degeneration involving motor neurons (HP:0007373)1.97704939
101Neoplasm of the heart (HP:0100544)1.97597627
102Amblyopia (HP:0000646)1.97513010
103Megalencephaly (HP:0001355)1.96795440
104Narrow nasal bridge (HP:0000446)1.96154216
105Neurofibrillary tangles (HP:0002185)1.95992470
106Craniofacial dystonia (HP:0012179)1.95780564
107Abnormality of the lower motor neuron (HP:0002366)1.95592185
108Bowel diverticulosis (HP:0005222)1.94920630
109Poor suck (HP:0002033)1.94745802
110Febrile seizures (HP:0002373)1.94388026
111Periorbital edema (HP:0100539)1.94287418
112Ulnar bowing (HP:0003031)1.93021848
113Attention deficit hyperactivity disorder (HP:0007018)1.92374538
114Specific learning disability (HP:0001328)1.92110309
115Patellar dislocation (HP:0002999)1.91780168
116Hypoplasia of the corpus callosum (HP:0002079)1.91776451
117Exotropia (HP:0000577)1.91123783
118Myelomeningocele (HP:0002475)1.89395837
119Agitation (HP:0000713)1.88597783
120Facial edema (HP:0000282)1.88034184
121Hip dysplasia (HP:0001385)1.87763477
122Spina bifida occulta (HP:0003298)1.86783126
123Broad phalanges of the hand (HP:0009768)1.86657895
124Sporadic (HP:0003745)1.85762673
125Progressive cerebellar ataxia (HP:0002073)1.84154142
126Broad thumb (HP:0011304)1.82760515
127Aqueductal stenosis (HP:0002410)1.82521113
128Heterotopia (HP:0002282)1.82123397
129Arnold-Chiari malformation (HP:0002308)1.81981447
130Adducted thumb (HP:0001181)1.81306004
131Spinal canal stenosis (HP:0003416)1.80924412
132Hand muscle atrophy (HP:0009130)1.80652596
133Broad finger (HP:0001500)1.80464453
134Infertility (HP:0000789)1.79668848
135Occipital encephalocele (HP:0002085)1.78916846
136Abnormal hair whorl (HP:0010721)1.78844362
137Short philtrum (HP:0000322)1.78588727
138Abnormality of DNA repair (HP:0003254)1.78363977
139Obstructive sleep apnea (HP:0002870)1.78208908
140Truncal ataxia (HP:0002078)1.78175927
141Abnormality of the corticospinal tract (HP:0002492)1.77958215
142Shoulder girdle muscle weakness (HP:0003547)1.77672892
143Hemiparesis (HP:0001269)1.77241239
144Vertebral arch anomaly (HP:0008438)1.76592878
145Urinary bladder sphincter dysfunction (HP:0002839)1.75526382
146Partial duplication of thumb phalanx (HP:0009944)1.74706169
147Pseudobulbar signs (HP:0002200)1.68600524
148Broad palm (HP:0001169)1.68534515
149Anteriorly placed anus (HP:0001545)1.68213388
150Intellectual disability, moderate (HP:0002342)1.67434489
151Male infertility (HP:0003251)1.65964551
152Shallow orbits (HP:0000586)1.65662016
153Partial duplication of the phalanx of hand (HP:0009999)1.62068205
154Lower limb asymmetry (HP:0100559)1.61593687
155Meningocele (HP:0002435)1.61456537
156Broad long bones (HP:0005622)1.59984875
157Cerebral inclusion bodies (HP:0100314)1.59863270
158Truncus arteriosus (HP:0001660)1.59780352
159Omphalocele (HP:0001539)1.59215890
160Broad phalanx (HP:0006009)1.59056882
161Thin ribs (HP:0000883)1.58199653
162Abnormality of the intervertebral disk (HP:0005108)1.57259962

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.66226650
2MAPK153.72770577
3MAP3K92.78482553
4DYRK22.67943589
5NTRK22.65803542
6NTRK12.63990041
7SIK22.47655462
8KSR12.46430059
9MINK12.28926740
10MAPK132.22442932
11LATS22.17073250
12IRAK22.09758392
13UHMK12.05564209
14ERBB31.92765428
15SIK31.87167042
16CDK191.84295703
17PAK61.82015952
18TNIK1.77576270
19NTRK31.72871798
20MAP3K121.63264895
21EPHB21.63130739
22EPHA31.61813955
23EEF2K1.61418294
24MAP2K71.59696923
25CDK121.57376055
26MAP3K41.55027075
27PKN21.49624954
28SMG11.38695308
29PRKD31.37939702
30FGFR21.37209487
31CDK51.27605894
32TYRO31.26713919
33CAMKK11.25754835
34PHKG21.24144522
35PHKG11.24144522
36PASK1.23248666
37FES1.22675418
38ERBB21.22276166
39TAOK11.21489604
40LIMK11.20112982
41RPS6KA21.19313455
42ACVR1B1.18691439
43RIPK11.13990965
44DAPK21.13876083
45DAPK11.04400715
46CSNK1G21.04294095
47CSNK1G30.99115805
48BRD40.98861564
49KSR20.98348655
50PNCK0.97668651
51ICK0.97251812
52CDK180.96184475
53DYRK1A0.93250042
54EPHA40.90022316
55DYRK1B0.89578678
56CDK150.87725584
57MAP3K60.86700299
58RET0.84878051
59MAP2K40.84137118
60CCNB10.83815661
61TRIB30.83041988
62SCYL20.83037746
63CAMK1G0.82293160
64CDK140.81889185
65CDK11A0.81879657
66MARK20.81088710
67MAP3K100.80060292
68TGFBR10.79274746
69DYRK30.79102406
70MTOR0.74926101
71CSNK1A1L0.70044474
72IRAK40.69556856
73SGK4940.67666149
74SGK2230.67666149
75PRKCZ0.66646632
76WNK30.66606207
77MAPK90.64902896
78ALK0.62671847
79BMPR1B0.62045644
80CDC70.60473470
81AURKA0.60427313
82BRSK10.59843809
83MAPK40.58796808
84PRKCH0.57865145
85MAP2K60.57847434
86PKN10.57695853
87CAMKK20.57654786
88CASK0.57083060
89CDK60.55096104
90CAMK10.54265216
91ATR0.54153423
92PAK30.52559416
93TESK20.51455502
94STK110.51216387
95PRKDC0.50082271
96STK160.50058271
97MKNK10.49946287
98GSK3B0.48925969
99KIT0.48863839
100CDK20.48714484
101CHEK20.47903056
102HIPK20.47721838
103CSNK1E0.47633808
104SYK0.47542482
105CDK10.45984702
106CAMK40.45439879
107CSNK1D0.44791428
108CSNK1G10.44486982
109NEK20.43681096
110CAMK1D0.41727105
111CDK40.41605290
112RPS6KL10.40543254
113RPS6KC10.40543254
114ILK0.40158633
115FYN0.39631055
116BCR0.38673546
117PRKCG0.38654306
118MATK0.38249756
119TTK0.37775692
120MAPK120.37521407
121MAP2K20.37106229
122RAF10.36623916
123PDGFRA0.35477680
124BRAF0.32235658
125RPS6KB10.31312718
126FGFR10.30146416
127MAPK140.29800934
128RPS6KA30.29343615
129MAPK80.28785586
130NEK10.28562594
131MKNK20.27870749
132PAK20.27733896
133RPS6KA10.27568756
134TESK10.26867389
135MAPK100.25702663
136SRPK10.24625619

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.74242386
2Axon guidance_Homo sapiens_hsa043602.58904280
3Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.20379448
4Synaptic vesicle cycle_Homo sapiens_hsa047212.18421422
5Circadian entrainment_Homo sapiens_hsa047131.98577888
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.93548483
7Olfactory transduction_Homo sapiens_hsa047401.93504191
8Colorectal cancer_Homo sapiens_hsa052101.92418615
9Dopaminergic synapse_Homo sapiens_hsa047281.89048129
10GABAergic synapse_Homo sapiens_hsa047271.82732775
11Endometrial cancer_Homo sapiens_hsa052131.76085548
12Cocaine addiction_Homo sapiens_hsa050301.75376947
13Cholinergic synapse_Homo sapiens_hsa047251.74165696
14Morphine addiction_Homo sapiens_hsa050321.73648307
15Glutamatergic synapse_Homo sapiens_hsa047241.68593675
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.64737997
17Neurotrophin signaling pathway_Homo sapiens_hsa047221.56411560
18Gap junction_Homo sapiens_hsa045401.54710924
19N-Glycan biosynthesis_Homo sapiens_hsa005101.53933999
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.53565404
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.51532766
22Long-term potentiation_Homo sapiens_hsa047201.46367029
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.41996983
24Glioma_Homo sapiens_hsa052141.38572953
25Non-small cell lung cancer_Homo sapiens_hsa052231.36435542
26ErbB signaling pathway_Homo sapiens_hsa040121.33719756
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.32397220
28Amphetamine addiction_Homo sapiens_hsa050311.31357135
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22545507
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22380650
31VEGF signaling pathway_Homo sapiens_hsa043701.21135286
32Alcoholism_Homo sapiens_hsa050341.19247473
33mRNA surveillance pathway_Homo sapiens_hsa030151.18758453
34Chronic myeloid leukemia_Homo sapiens_hsa052201.16044175
35Oxytocin signaling pathway_Homo sapiens_hsa049211.14043087
36Notch signaling pathway_Homo sapiens_hsa043301.13538445
37Basal cell carcinoma_Homo sapiens_hsa052171.10857942
38Type II diabetes mellitus_Homo sapiens_hsa049301.10698335
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09417421
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09227701
41Estrogen signaling pathway_Homo sapiens_hsa049151.09085732
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08178659
43Oocyte meiosis_Homo sapiens_hsa041141.06405349
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.05514408
45Tight junction_Homo sapiens_hsa045301.03772439
46Adherens junction_Homo sapiens_hsa045201.03743004
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01409272
48Central carbon metabolism in cancer_Homo sapiens_hsa052300.98738723
49Serotonergic synapse_Homo sapiens_hsa047260.98709447
50Long-term depression_Homo sapiens_hsa047300.98598422
51Melanogenesis_Homo sapiens_hsa049160.96494619
52Renal cell carcinoma_Homo sapiens_hsa052110.96127491
53Insulin secretion_Homo sapiens_hsa049110.95595075
54GnRH signaling pathway_Homo sapiens_hsa049120.95398646
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94397385
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91898364
57Salivary secretion_Homo sapiens_hsa049700.90448260
58Dilated cardiomyopathy_Homo sapiens_hsa054140.90267017
59mTOR signaling pathway_Homo sapiens_hsa041500.88472658
60Spliceosome_Homo sapiens_hsa030400.88315437
61Wnt signaling pathway_Homo sapiens_hsa043100.88127685
62cAMP signaling pathway_Homo sapiens_hsa040240.86327412
63Taste transduction_Homo sapiens_hsa047420.83292707
64Cardiac muscle contraction_Homo sapiens_hsa042600.83285279
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.81498361
66Acute myeloid leukemia_Homo sapiens_hsa052210.81291766
67DNA replication_Homo sapiens_hsa030300.80433677
68Choline metabolism in cancer_Homo sapiens_hsa052310.79780763
69Gastric acid secretion_Homo sapiens_hsa049710.79631246
70Renin secretion_Homo sapiens_hsa049240.79587422
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79472292
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79358911
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75536932
74Hedgehog signaling pathway_Homo sapiens_hsa043400.74272805
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.73134231
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72796913
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71972059
78Pancreatic cancer_Homo sapiens_hsa052120.71831184
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.70583994
80Insulin signaling pathway_Homo sapiens_hsa049100.68848163
81MAPK signaling pathway_Homo sapiens_hsa040100.68546665
82Viral myocarditis_Homo sapiens_hsa054160.68355468
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67612895
84B cell receptor signaling pathway_Homo sapiens_hsa046620.67596546
85AMPK signaling pathway_Homo sapiens_hsa041520.65064167
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65050688
87Prolactin signaling pathway_Homo sapiens_hsa049170.63806583
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62972782
89Calcium signaling pathway_Homo sapiens_hsa040200.62736072
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62077527
91Hippo signaling pathway_Homo sapiens_hsa043900.62018762
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61619225
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60994695
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59960084
95Lysine degradation_Homo sapiens_hsa003100.59936798
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59233343
97MicroRNAs in cancer_Homo sapiens_hsa052060.57774103
98Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54650064
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54386653
100Rap1 signaling pathway_Homo sapiens_hsa040150.52990962
101Endocytosis_Homo sapiens_hsa041440.52793177
102Thyroid cancer_Homo sapiens_hsa052160.52243080
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51904690
104Thyroid hormone synthesis_Homo sapiens_hsa049180.51711736
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50187044
106Phototransduction_Homo sapiens_hsa047440.50105232
107Pathways in cancer_Homo sapiens_hsa052000.49310237
108Chemokine signaling pathway_Homo sapiens_hsa040620.49261844
109T cell receptor signaling pathway_Homo sapiens_hsa046600.49055906
110Salmonella infection_Homo sapiens_hsa051320.48603643
111Prion diseases_Homo sapiens_hsa050200.48401954
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47813088
113Ras signaling pathway_Homo sapiens_hsa040140.47789536
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47121554
115Inositol phosphate metabolism_Homo sapiens_hsa005620.44880102
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44643376

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