PLPPR4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the lipid phosphate phosphatase (LPP) family. LPPs catalyze the dephosphorylation of a number of bioactive lipid mediators that regulate a variety of cell functions. This protein is specifically expressed in neurons. It is located in the membranes of outgrowing axons and has been shown to be important for axonal outgrowth during development and regenerative sprouting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ionotropic glutamate receptor signaling pathway (GO:0035235)5.66111221
2vocalization behavior (GO:0071625)5.64973342
3cerebellar granule cell differentiation (GO:0021707)5.58521289
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.56292476
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.45978303
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.43172867
7glutamate receptor signaling pathway (GO:0007215)5.25905490
8protein localization to synapse (GO:0035418)5.21000097
9regulation of glutamate receptor signaling pathway (GO:1900449)5.04598388
10neuron cell-cell adhesion (GO:0007158)4.99574103
11locomotory exploration behavior (GO:0035641)4.90692083
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.88751396
13synaptic vesicle exocytosis (GO:0016079)4.86719876
14regulation of long-term neuronal synaptic plasticity (GO:0048169)4.69123935
15synaptic transmission, glutamatergic (GO:0035249)4.64101130
16regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.61958994
17neuron-neuron synaptic transmission (GO:0007270)4.52128767
18sodium ion export (GO:0071436)4.50732210
19glutamate secretion (GO:0014047)4.50203237
20gamma-aminobutyric acid signaling pathway (GO:0007214)4.49954355
21exploration behavior (GO:0035640)4.49689991
22synaptic vesicle maturation (GO:0016188)4.46461352
23neuronal action potential propagation (GO:0019227)4.40903357
24neuron recognition (GO:0008038)4.40797674
25regulation of neuronal synaptic plasticity (GO:0048168)4.32212112
26regulation of synaptic vesicle exocytosis (GO:2000300)4.28357824
27positive regulation of phosphoprotein phosphatase activity (GO:0032516)4.18952337
28neurotransmitter-gated ion channel clustering (GO:0072578)4.16741546
29short-term memory (GO:0007614)4.16157361
30regulation of excitatory postsynaptic membrane potential (GO:0060079)4.15681720
31positive regulation of synapse maturation (GO:0090129)4.15405861
32cerebellar Purkinje cell differentiation (GO:0021702)4.12255072
33long-term memory (GO:0007616)4.00985759
34regulation of dendritic spine morphogenesis (GO:0061001)3.97771306
35regulation of synaptic vesicle transport (GO:1902803)3.95088718
36regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.94710060
37regulation of postsynaptic membrane potential (GO:0060078)3.94080117
38axonal fasciculation (GO:0007413)3.93935744
39synaptic vesicle docking involved in exocytosis (GO:0016081)3.93334983
40presynaptic membrane assembly (GO:0097105)3.89577307
41long-term synaptic potentiation (GO:0060291)3.87865762
42cerebellar Purkinje cell layer development (GO:0021680)3.85538296
43dendritic spine morphogenesis (GO:0060997)3.84807162
44negative regulation of synaptic transmission, GABAergic (GO:0032229)3.84008417
45negative regulation of dendrite morphogenesis (GO:0050774)3.82876047
46regulation of synaptic plasticity (GO:0048167)3.82558532
47behavioral defense response (GO:0002209)3.81539080
48behavioral fear response (GO:0001662)3.81539080
49G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.80428820
50response to histamine (GO:0034776)3.78649160
51cellular sodium ion homeostasis (GO:0006883)3.75338645
52postsynaptic membrane organization (GO:0001941)3.74915117
53neurotransmitter secretion (GO:0007269)3.72203508
54transmission of nerve impulse (GO:0019226)3.71590984
55regulation of synapse structural plasticity (GO:0051823)3.70394690
56G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.68125578
57positive regulation of membrane potential (GO:0045838)3.67475608
58fear response (GO:0042596)3.63757975
59layer formation in cerebral cortex (GO:0021819)3.63224863
60cellular potassium ion homeostasis (GO:0030007)3.61341502
61positive regulation of dendritic spine morphogenesis (GO:0061003)3.61215851
62cell differentiation in hindbrain (GO:0021533)3.59335181
63prepulse inhibition (GO:0060134)3.57998239
64regulation of synaptic transmission, glutamatergic (GO:0051966)3.53240954
65presynaptic membrane organization (GO:0097090)3.52631811
66gamma-aminobutyric acid transport (GO:0015812)3.50226862
67membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.49176973
68C4-dicarboxylate transport (GO:0015740)3.49003754
69positive regulation of neurotransmitter secretion (GO:0001956)3.46448985
70synaptic vesicle endocytosis (GO:0048488)3.46142448
71regulation of dendritic spine development (GO:0060998)3.45604094
72regulation of vesicle fusion (GO:0031338)3.39264863
73dendritic spine organization (GO:0097061)3.37629257
74long term synaptic depression (GO:0060292)3.36771231
75regulation of female receptivity (GO:0045924)3.35482925
76positive regulation of dendritic spine development (GO:0060999)3.34466570
77regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.32692147
78learning (GO:0007612)3.31469908
79regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.31024350
80serotonin metabolic process (GO:0042428)3.30860472
81regulation of neurotransmitter transport (GO:0051588)3.26341520
82positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.26175588
83regulation of synapse maturation (GO:0090128)3.25626683
84positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.24926713
85potassium ion homeostasis (GO:0055075)3.24355979
86regulation of glutamate secretion (GO:0014048)3.24190445
87innervation (GO:0060384)3.24099419
88proline transport (GO:0015824)3.21283547
89cell communication by electrical coupling (GO:0010644)3.21209801
90membrane depolarization (GO:0051899)3.20753903
91regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.19733021
92cochlea development (GO:0090102)3.18225525
93neurotransmitter transport (GO:0006836)3.16485235
94behavioral response to cocaine (GO:0048148)3.15893320
95positive regulation of muscle hypertrophy (GO:0014742)3.15490534
96positive regulation of cardiac muscle hypertrophy (GO:0010613)3.15490534
97negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.15477059
98female mating behavior (GO:0060180)3.14918564
99retinal cone cell development (GO:0046549)3.13519137
100startle response (GO:0001964)3.13080412
101positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.11628881
102regulation of voltage-gated calcium channel activity (GO:1901385)3.11605820
103negative regulation of dendrite development (GO:2000171)3.07572783
104regulation of neurotransmitter secretion (GO:0046928)3.06966641
105positive regulation of neurotransmitter transport (GO:0051590)3.05973329
106synapse assembly (GO:0007416)3.04550936
107detection of calcium ion (GO:0005513)3.02701024
108acidic amino acid transport (GO:0015800)3.02445786
109regulation of synaptic transmission (GO:0050804)3.00384740
110synaptic transmission (GO:0007268)3.00058050
111positive regulation of synaptic transmission, GABAergic (GO:0032230)2.98436271
112L-amino acid import (GO:0043092)2.97152416
113vesicle transport along microtubule (GO:0047496)2.95372903
114positive regulation of synaptic transmission (GO:0050806)2.94610569
115neuromuscular process controlling balance (GO:0050885)2.94384107
116chemosensory behavior (GO:0007635)2.94273971
117amino acid import (GO:0043090)2.92857366
118positive regulation of potassium ion transmembrane transport (GO:1901381)2.92555067
119regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.92511341
120synaptic transmission, dopaminergic (GO:0001963)2.90883909
121central nervous system projection neuron axonogenesis (GO:0021952)2.90319991
122cell communication involved in cardiac conduction (GO:0086065)2.89920361
123regulation of neurotransmitter levels (GO:0001505)2.89701216
124cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.87812325
125social behavior (GO:0035176)2.87402146
126intraspecies interaction between organisms (GO:0051703)2.87402146
127membrane depolarization during action potential (GO:0086010)2.87068721
128auditory behavior (GO:0031223)2.86643484
129regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.85787424

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.28728543
2GBX2_23144817_ChIP-Seq_PC3_Human4.03789195
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.18641772
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.17383721
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.07451404
6SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.76056569
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63552603
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63552603
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59179571
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.57222547
11REST_21632747_ChIP-Seq_MESCs_Mouse2.57020653
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.50418020
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50146559
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44345362
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.38783602
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.37672495
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.37088794
18TAF15_26573619_Chip-Seq_HEK293_Human2.17409840
19DROSHA_22980978_ChIP-Seq_HELA_Human2.14174752
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.12108847
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.11892965
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.11553427
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11196907
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06128724
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.04252068
26REST_18959480_ChIP-ChIP_MESCs_Mouse1.98344156
27AR_21572438_ChIP-Seq_LNCaP_Human1.96708124
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91695139
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88862204
30SMAD4_21799915_ChIP-Seq_A2780_Human1.83672291
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76351031
32P300_19829295_ChIP-Seq_ESCs_Human1.74470305
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.71184357
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68479712
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66107446
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65027115
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61443785
38ZNF274_21170338_ChIP-Seq_K562_Hela1.59614961
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59238197
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.57640859
41FUS_26573619_Chip-Seq_HEK293_Human1.55247798
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52611451
43VDR_22108803_ChIP-Seq_LS180_Human1.51625070
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.49697898
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.46236501
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44928853
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44421464
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43289884
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42614340
50AR_25329375_ChIP-Seq_VCAP_Human1.42341504
51IGF1R_20145208_ChIP-Seq_DFB_Human1.40687009
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40335187
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.39345834
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38071170
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.37588953
56TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34754093
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.32151829
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.30339252
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29396809
60STAT3_23295773_ChIP-Seq_U87_Human1.29336284
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25284518
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.24522757
63EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22797341
64TP53_16413492_ChIP-PET_HCT116_Human1.22022085
65PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21450361
66RING1B_27294783_Chip-Seq_ESCs_Mouse1.20390883
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20351679
68PRDM14_20953172_ChIP-Seq_ESCs_Human1.18479608
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17928297
70RNF2_27304074_Chip-Seq_NSC_Mouse1.17833034
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17099964
72RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.17013035
73TP53_18474530_ChIP-ChIP_U2OS_Human1.16996202
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16143950
75TCF4_23295773_ChIP-Seq_U87_Human1.15627382
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.14361304
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14320185
78AR_19668381_ChIP-Seq_PC3_Human1.13649941
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12850774
80LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12458239
81RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11095985
82RUNX2_22187159_ChIP-Seq_PCA_Human1.10607639
83JUN_21703547_ChIP-Seq_K562_Human1.10263895
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08066284
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07111354
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06287618
87P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05826788
88RING1B_27294783_Chip-Seq_NPCs_Mouse1.05626865
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.05427377
90YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04130254
91SOX9_26525672_Chip-Seq_HEART_Mouse1.02659729
92AHR_22903824_ChIP-Seq_MCF-7_Human1.01599914
93ER_23166858_ChIP-Seq_MCF-7_Human1.01230658
94BCAT_22108803_ChIP-Seq_LS180_Human1.00745178
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00421068
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00421068
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00363269
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00329430
99RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99988784
100WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99579367
101FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98687219
102CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97127798
103NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97054375
104NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97054375
105SMAD3_21741376_ChIP-Seq_HESCs_Human0.96884758
106CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96282833
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93283375
108KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93088242
109FLI1_21867929_ChIP-Seq_TH2_Mouse0.93039562
110KDM2B_26808549_Chip-Seq_REH_Human0.91794240
111E2F1_18555785_Chip-Seq_ESCs_Mouse0.90385460
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89616684
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89067027
114SMAD4_21741376_ChIP-Seq_HESCs_Human0.88832446
115SMAD3_21741376_ChIP-Seq_ESCs_Human0.88514252

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.68037914
2MP0003880_abnormal_central_pattern5.69863114
3MP0003635_abnormal_synaptic_transmissio4.26692746
4MP0004270_analgesia3.72053130
5MP0009745_abnormal_behavioral_response3.67699440
6MP0002063_abnormal_learning/memory/cond3.55570479
7MP0001968_abnormal_touch/_nociception3.17431049
8MP0002064_seizures3.14142692
9MP0002572_abnormal_emotion/affect_behav2.96038616
10MP0002822_catalepsy2.81880381
11MP0002736_abnormal_nociception_after2.72639541
12MP0009046_muscle_twitch2.70594660
13MP0001501_abnormal_sleep_pattern2.63932754
14MP0002272_abnormal_nervous_system2.62582842
15MP0002735_abnormal_chemical_nociception2.49795609
16MP0001486_abnormal_startle_reflex2.44667095
17MP0001440_abnormal_grooming_behavior2.41973047
18MP0002734_abnormal_mechanical_nocicepti2.40196839
19MP0005423_abnormal_somatic_nervous2.18133404
20MP0003329_amyloid_beta_deposits2.11512914
21MP0002733_abnormal_thermal_nociception1.98040650
22MP0002067_abnormal_sensory_capabilities1.96674957
23MP0000778_abnormal_nervous_system1.91615830
24MP0001970_abnormal_pain_threshold1.86567505
25MP0009780_abnormal_chondrocyte_physiolo1.84565421
26MP0001188_hyperpigmentation1.82771459
27MP0002184_abnormal_innervation1.82508904
28MP0000569_abnormal_digit_pigmentation1.76248690
29MP0006276_abnormal_autonomic_nervous1.74217593
30MP0002557_abnormal_social/conspecific_i1.70158654
31MP0005386_behavior/neurological_phenoty1.69433993
32MP0004924_abnormal_behavior1.69433993
33MP0001529_abnormal_vocalization1.66689376
34MP0002638_abnormal_pupillary_reflex1.64394004
35MP0002909_abnormal_adrenal_gland1.59257343
36MP0003879_abnormal_hair_cell1.59182697
37MP0004811_abnormal_neuron_physiology1.52296591
38MP0008569_lethality_at_weaning1.50209173
39MP0002837_dystrophic_cardiac_calcinosis1.46730831
40MP0003787_abnormal_imprinting1.44929242
41MP0001984_abnormal_olfaction1.43308526
42MP0005646_abnormal_pituitary_gland1.42934383
43MP0004858_abnormal_nervous_system1.38703344
44MP0000955_abnormal_spinal_cord1.38159436
45MP0002066_abnormal_motor_capabilities/c1.36217314
46MP0001905_abnormal_dopamine_level1.34606772
47MP0002882_abnormal_neuron_morphology1.32685649
48MP0005409_darkened_coat_color1.25759827
49MP0004885_abnormal_endolymph1.21752154
50MP0003633_abnormal_nervous_system1.21180416
51MP0001502_abnormal_circadian_rhythm1.19339626
52MP0005645_abnormal_hypothalamus_physiol1.14630774
53MP0004145_abnormal_muscle_electrophysio1.12886615
54MP0010386_abnormal_urinary_bladder1.08738256
55MP0002876_abnormal_thyroid_physiology1.06205754
56MP0004142_abnormal_muscle_tone1.05596257
57MP0002152_abnormal_brain_morphology1.05418730
58MP0005623_abnormal_meninges_morphology1.05175356
59MP0003631_nervous_system_phenotype1.04672989
60MP0000604_amyloidosis1.00549083
61MP0004484_altered_response_of0.96093086
62MP0005551_abnormal_eye_electrophysiolog0.94051994
63MP0002069_abnormal_eating/drinking_beha0.92744871
64MP0008874_decreased_physiological_sensi0.92435607
65MP0004510_myositis0.90306379
66MP0004742_abnormal_vestibular_system0.90104244
67MP0008872_abnormal_physiological_respon0.89910469
68MP0001963_abnormal_hearing_physiology0.88149039
69MP0005535_abnormal_body_temperature0.86866632
70MP0000751_myopathy0.86865735
71MP0004085_abnormal_heartbeat0.86242990
72MP0006292_abnormal_olfactory_placode0.86081652
73MP0002229_neurodegeneration0.85740739
74MP0004215_abnormal_myocardial_fiber0.83017744
75MP0003121_genomic_imprinting0.75583648
76MP0003122_maternal_imprinting0.74447237
77MP0003283_abnormal_digestive_organ0.74438556
78MP0001177_atelectasis0.73939451
79MP0000631_abnormal_neuroendocrine_gland0.73180846
80MP0008877_abnormal_DNA_methylation0.73045930
81MP0003075_altered_response_to0.72818317
82MP0002752_abnormal_somatic_nervous0.72507945
83MP0001664_abnormal_digestion0.72226229
84MP0006035_abnormal_mitochondrial_morpho0.71591329
85MP0001299_abnormal_eye_distance/0.71504384
86MP0003632_abnormal_nervous_system0.71496792
87MP0000013_abnormal_adipose_tissue0.68852524
88MP0003634_abnormal_glial_cell0.67400198
89MP0003123_paternal_imprinting0.66781987
90MP0005499_abnormal_olfactory_system0.66178818
91MP0005394_taste/olfaction_phenotype0.66178818
92MP0001485_abnormal_pinna_reflex0.65171695
93MP0005171_absent_coat_pigmentation0.63882971
94MP0000026_abnormal_inner_ear0.62839973
95MP0002234_abnormal_pharynx_morphology0.62640028
96MP0005620_abnormal_muscle_contractility0.60229352
97MP0000920_abnormal_myelination0.58790362
98MP0002102_abnormal_ear_morphology0.58231534
99MP0009379_abnormal_foot_pigmentation0.57632018
100MP0004043_abnormal_pH_regulation0.57269070
101MP0010769_abnormal_survival0.56780576
102MP0002082_postnatal_lethality0.56476636
103MP0010770_preweaning_lethality0.56476636
104MP0001765_abnormal_ion_homeostasis0.56469842
105MP0005187_abnormal_penis_morphology0.55838159
106MP0001986_abnormal_taste_sensitivity0.55815499
107MP0010234_abnormal_vibrissa_follicle0.54922860
108MP0003137_abnormal_impulse_conducting0.53862815
109MP0010768_mortality/aging0.53358646
110MP0006072_abnormal_retinal_apoptosis0.53063690
111MP0005595_abnormal_vascular_smooth0.52722984
112MP0003861_abnormal_nervous_system0.52601296
113MP0000534_abnormal_ureter_morphology0.52118232
114MP0002090_abnormal_vision0.52113270
115MP0004233_abnormal_muscle_weight0.50253704
116MP0000015_abnormal_ear_pigmentation0.50012971
117MP0002751_abnormal_autonomic_nervous0.49621354
118MP0003956_abnormal_body_size0.49522916
119MP0003938_abnormal_ear_development0.48578513
120MP0003690_abnormal_glial_cell0.48430211
121MP0004036_abnormal_muscle_relaxation0.46637488
122MP0001943_abnormal_respiration0.45348850

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.95181570
2Focal seizures (HP:0007359)6.06369096
3Myokymia (HP:0002411)5.87026758
4Epileptic encephalopathy (HP:0200134)5.50470919
5Visual hallucinations (HP:0002367)5.35065044
6Atonic seizures (HP:0010819)5.21232809
7Hyperventilation (HP:0002883)5.00260648
8Febrile seizures (HP:0002373)4.74923863
9Absence seizures (HP:0002121)4.70037383
10Dialeptic seizures (HP:0011146)4.41681317
11Generalized tonic-clonic seizures (HP:0002069)4.16755089
12Broad-based gait (HP:0002136)4.10300579
13Progressive cerebellar ataxia (HP:0002073)3.93341122
14Cerebral inclusion bodies (HP:0100314)3.84776780
15Amblyopia (HP:0000646)3.55013750
16Excessive salivation (HP:0003781)3.52233891
17Drooling (HP:0002307)3.52233891
18Poor eye contact (HP:0000817)3.49669509
19Neurofibrillary tangles (HP:0002185)3.45547842
20Supranuclear gaze palsy (HP:0000605)3.37278393
21Limb dystonia (HP:0002451)3.30433473
22Gaze-evoked nystagmus (HP:0000640)3.19505385
23Absent speech (HP:0001344)3.11862733
24Impaired social interactions (HP:0000735)3.10976402
25Abnormal social behavior (HP:0012433)3.10976402
26Dysmetria (HP:0001310)3.05963679
27Epileptiform EEG discharges (HP:0011182)3.05827441
28Postural tremor (HP:0002174)3.05610306
29Dysdiadochokinesis (HP:0002075)3.05280777
30Abnormality of binocular vision (HP:0011514)3.00646672
31Diplopia (HP:0000651)3.00646672
32Action tremor (HP:0002345)2.99677631
33Anxiety (HP:0000739)2.92963099
34Truncal ataxia (HP:0002078)2.88555080
35Hemiparesis (HP:0001269)2.85402407
36Impaired vibration sensation in the lower limbs (HP:0002166)2.85159681
37Mutism (HP:0002300)2.78424291
38Inability to walk (HP:0002540)2.76006830
39EEG with generalized epileptiform discharges (HP:0011198)2.72512434
40Depression (HP:0000716)2.71430408
41Horizontal nystagmus (HP:0000666)2.69817151
42Progressive inability to walk (HP:0002505)2.68444863
43Protruding tongue (HP:0010808)2.62415359
44Urinary bladder sphincter dysfunction (HP:0002839)2.58392260
45Akinesia (HP:0002304)2.55548568
46Stereotypic behavior (HP:0000733)2.55046615
47Impaired smooth pursuit (HP:0007772)2.53628906
48Abnormal eating behavior (HP:0100738)2.52278487
49Hypsarrhythmia (HP:0002521)2.47016867
50Abnormality of saccadic eye movements (HP:0000570)2.42290918
51Abnormality of salivation (HP:0100755)2.41381210
52Genetic anticipation (HP:0003743)2.41226191
53Insidious onset (HP:0003587)2.37805315
54Termporal pattern (HP:0011008)2.37805315
55Generalized myoclonic seizures (HP:0002123)2.36395871
56Delusions (HP:0000746)2.36175807
57Amyotrophic lateral sclerosis (HP:0007354)2.32369552
58Postural instability (HP:0002172)2.31427265
59Status epilepticus (HP:0002133)2.30335333
60Fetal akinesia sequence (HP:0001989)2.29587156
61Thickened helices (HP:0000391)2.27232293
62Scanning speech (HP:0002168)2.25667939
63Abnormality of the lower motor neuron (HP:0002366)2.25600046
64Dynein arm defect of respiratory motile cilia (HP:0012255)2.23449617
65Absent/shortened dynein arms (HP:0200106)2.23449617
66Ankle clonus (HP:0011448)2.23337523
67Abnormality of the corticospinal tract (HP:0002492)2.23192063
68Fair hair (HP:0002286)2.21335749
69Craniofacial dystonia (HP:0012179)2.19959112
70Bradykinesia (HP:0002067)2.19607311
71Inappropriate behavior (HP:0000719)2.17354934
72Blue irides (HP:0000635)2.17093141
73Hydroureter (HP:0000072)2.12852953
74Generalized hypopigmentation of hair (HP:0011358)2.11264290
75Papilledema (HP:0001085)2.10560769
76Abnormal ciliary motility (HP:0012262)2.08731476
77Widely spaced teeth (HP:0000687)2.08726931
78Urinary urgency (HP:0000012)2.08677012
79Retinal dysplasia (HP:0007973)2.07892416
80Spastic gait (HP:0002064)2.07481519
81Abnormality of ocular smooth pursuit (HP:0000617)2.07395561
82Torticollis (HP:0000473)2.04539709
83Polyphagia (HP:0002591)2.00244521
84Intention tremor (HP:0002080)1.98533909
85Limb ataxia (HP:0002070)1.95468954
86Sleep apnea (HP:0010535)1.94618621
87Focal dystonia (HP:0004373)1.94310433
88Psychosis (HP:0000709)1.94104000
89Gait imbalance (HP:0002141)1.93702945
90Impaired vibratory sensation (HP:0002495)1.93092405
91Syncope (HP:0001279)1.92055219
92Gait ataxia (HP:0002066)1.88724415
93Spastic tetraplegia (HP:0002510)1.88549000
94Type II lissencephaly (HP:0007260)1.87579016
95Morphological abnormality of the pyramidal tract (HP:0002062)1.87381359
96Lower limb amyotrophy (HP:0007210)1.85840427
97Hemiplegia (HP:0002301)1.84354563
98Clumsiness (HP:0002312)1.83212524
99Gastroesophageal reflux (HP:0002020)1.82960199
100Lower limb muscle weakness (HP:0007340)1.82646011
101Dysmetric saccades (HP:0000641)1.82191735
102Incomplete penetrance (HP:0003829)1.81307832
103Pheochromocytoma (HP:0002666)1.81132405
104Abnormal respiratory motile cilium physiology (HP:0012261)1.81064203
105Prolonged QT interval (HP:0001657)1.80782647
106Megalencephaly (HP:0001355)1.80727955
107Esotropia (HP:0000565)1.80183858
108Degeneration of the lateral corticospinal tracts (HP:0002314)1.78125097
109Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.78125097
110Rapidly progressive (HP:0003678)1.77314230
111Exotropia (HP:0000577)1.75939982
112Obstructive sleep apnea (HP:0002870)1.75663003
113Neuronal loss in central nervous system (HP:0002529)1.75343038
114Heterochromia iridis (HP:0001100)1.74798900
115Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.74614734
116Slow progression (HP:0003677)1.72281806
117Clonus (HP:0002169)1.66324769
118Tetraplegia (HP:0002445)1.65991034
119Apathy (HP:0000741)1.59121434
120Rigidity (HP:0002063)1.56746504
121Short chin (HP:0000331)1.54818959
122Paraplegia (HP:0010550)1.51921151
123Cerebral hypomyelination (HP:0006808)1.51763383

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.77941568
2NTRK34.94963494
3RIPK43.51349327
4MAP3K93.40477853
5MAP3K42.76679747
6CASK2.75196469
7MARK12.62380909
8MAP2K72.51889066
9MINK12.44035853
10PNCK2.29825335
11DAPK22.10930317
12PLK22.08349824
13KSR21.99682961
14MAP3K121.89835912
15KSR11.84981880
16MAP2K41.78279922
17NTRK11.76011565
18BMPR21.70011865
19DAPK11.69783217
20MAP3K131.68489844
21PAK61.68251255
22NTRK21.65789549
23SIK21.64836558
24TNIK1.64675639
25ARAF1.63899489
26FES1.56046191
27GRK51.54453935
28CDK51.44040229
29PTK2B1.35128690
30CSNK1G31.35071178
31PRPF4B1.33667534
32CSNK1A1L1.31126376
33PRKCG1.26851867
34CAMK2B1.26681236
35CAMK2A1.25612051
36RAF11.21347355
37FRK1.20811612
38CAMKK11.20108531
39MAPK131.14845656
40CSNK1G11.11263312
41NME11.09815897
42PRKD31.08704165
43FGR1.05231552
44CDK190.94814681
45LIMK10.89889141
46MAP3K20.89440123
47FGFR20.87896289
48DYRK1A0.86592773
49TESK10.85584427
50MYLK0.77671997
51STK380.76003538
52CAMK10.75463176
53CDK180.75423297
54CDK140.75123969
55SGK10.74290770
56CDK150.72675564
57CAMKK20.71714410
58PRKG10.71381708
59CAMK2D0.68763707
60FER0.68111473
61PRKCE0.68101227
62GRK70.66452206
63OXSR10.65811426
64STK110.64817757
65LATS20.64221310
66MAP3K60.63638510
67CDK11A0.62783863
68TYRO30.61992584
69UHMK10.61986592
70DMPK0.60024019
71PAK30.59029551
72MARK20.57200082
73EPHA30.56858203
74PHKG20.55487273
75PHKG10.55487273
76CAMK40.54851764
77GRK60.54342891
78PRKG20.53970437
79TAOK10.52859044
80CSNK1G20.52207822
81SGK2230.52104729
82SGK4940.52104729
83AKT30.52023097
84PRKCZ0.51431455
85PDPK10.49704907
86RET0.49642842
87MAP2K10.49395235
88PDK10.48723163
89BRAF0.48216132
90MAP3K10.47945502
91CAMK2G0.47306003
92CSNK1D0.47256433
93FYN0.45507315
94DAPK30.45399633
95SGK30.44150732
96CCNB10.43792241
97MAPK70.43671363
98SGK20.43111083
99MAPK120.41648995
100WNK10.41060456
101MAP3K70.40383865
102MOS0.39909176
103MUSK0.39122150
104ROCK20.38983837
105PRKCH0.38716995
106MAPK100.38667071
107CSNK1A10.38162881
108DYRK20.37403425
109RIPK10.37342334
110RPS6KA30.36948674
111ROCK10.36386453
112PKN10.36004971
113PRKCQ0.35391309
114CSNK1E0.35175061
115PINK10.34949546
116TNK20.34817638
117ALK0.33860495
118BCR0.33358278
119CAMK1G0.32760731
120PRKACA0.32647455
121PDGFRA0.32174256
122SRC0.31416359
123PRKCA0.30107470
124PRKCB0.29126194
125SIK30.27831858
126NEK60.27740347

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.41383892
2Long-term potentiation_Homo sapiens_hsa047203.14801105
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.01649167
4Circadian entrainment_Homo sapiens_hsa047132.83870407
5Glutamatergic synapse_Homo sapiens_hsa047242.78593547
6Synaptic vesicle cycle_Homo sapiens_hsa047212.75179494
7Amphetamine addiction_Homo sapiens_hsa050312.74933032
8GABAergic synapse_Homo sapiens_hsa047272.67656731
9Morphine addiction_Homo sapiens_hsa050322.63367559
10Olfactory transduction_Homo sapiens_hsa047402.44360540
11Salivary secretion_Homo sapiens_hsa049702.39942240
12Dopaminergic synapse_Homo sapiens_hsa047282.29764038
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.14701286
14Taste transduction_Homo sapiens_hsa047422.09796741
15Renin secretion_Homo sapiens_hsa049241.99799698
16Long-term depression_Homo sapiens_hsa047301.98416135
17Serotonergic synapse_Homo sapiens_hsa047261.96507822
18Insulin secretion_Homo sapiens_hsa049111.85497842
19Gastric acid secretion_Homo sapiens_hsa049711.85165606
20Calcium signaling pathway_Homo sapiens_hsa040201.84993865
21Cholinergic synapse_Homo sapiens_hsa047251.79954077
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.76364933
23Oxytocin signaling pathway_Homo sapiens_hsa049211.76044662
24Collecting duct acid secretion_Homo sapiens_hsa049661.63678252
25Cocaine addiction_Homo sapiens_hsa050301.58081749
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.54242591
27GnRH signaling pathway_Homo sapiens_hsa049121.43260824
28Nitrogen metabolism_Homo sapiens_hsa009101.38735696
29cAMP signaling pathway_Homo sapiens_hsa040241.37814085
30Gap junction_Homo sapiens_hsa045401.34019053
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33178592
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30792358
33Axon guidance_Homo sapiens_hsa043601.23592871
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22553714
35cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15375128
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14029815
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12551943
38Estrogen signaling pathway_Homo sapiens_hsa049151.12544691
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08446388
40Melanogenesis_Homo sapiens_hsa049161.05609642
41Phototransduction_Homo sapiens_hsa047441.03521613
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03297173
43Glioma_Homo sapiens_hsa052141.02962781
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.99842953
45Vibrio cholerae infection_Homo sapiens_hsa051100.98700784
46Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.97694264
47Pancreatic secretion_Homo sapiens_hsa049720.97273938
48Cardiac muscle contraction_Homo sapiens_hsa042600.96611560
49Type II diabetes mellitus_Homo sapiens_hsa049300.94930895
50ErbB signaling pathway_Homo sapiens_hsa040120.89536946
51Vitamin B6 metabolism_Homo sapiens_hsa007500.85189638
52Choline metabolism in cancer_Homo sapiens_hsa052310.81978920
53Oocyte meiosis_Homo sapiens_hsa041140.81671303
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79336894
55Dorso-ventral axis formation_Homo sapiens_hsa043200.75857954
56Thyroid hormone synthesis_Homo sapiens_hsa049180.75224867
57Alzheimers disease_Homo sapiens_hsa050100.75102065
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74911876
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.74738310
60African trypanosomiasis_Homo sapiens_hsa051430.74599668
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72786337
62VEGF signaling pathway_Homo sapiens_hsa043700.72245872
63MAPK signaling pathway_Homo sapiens_hsa040100.65922313
64Dilated cardiomyopathy_Homo sapiens_hsa054140.63589445
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61434105
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60103526
67Ras signaling pathway_Homo sapiens_hsa040140.59404948
68Glucagon signaling pathway_Homo sapiens_hsa049220.58749860
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55067231
70Rap1 signaling pathway_Homo sapiens_hsa040150.54511343
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52148315
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50934810
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.50443810
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46707804
75Oxidative phosphorylation_Homo sapiens_hsa001900.46666241
76Wnt signaling pathway_Homo sapiens_hsa043100.44917573
77Butanoate metabolism_Homo sapiens_hsa006500.44205213
78Inositol phosphate metabolism_Homo sapiens_hsa005620.43550990
79Alcoholism_Homo sapiens_hsa050340.43233396
80Type I diabetes mellitus_Homo sapiens_hsa049400.42528714
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.42317146
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39877040
83Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38657568
84Prion diseases_Homo sapiens_hsa050200.38230997
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37545973
86Circadian rhythm_Homo sapiens_hsa047100.37389990
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34807298
88Bile secretion_Homo sapiens_hsa049760.34126413
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32290494
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31665014
91Rheumatoid arthritis_Homo sapiens_hsa053230.30767393
92Non-small cell lung cancer_Homo sapiens_hsa052230.30560037
93Mineral absorption_Homo sapiens_hsa049780.30255702
94Renal cell carcinoma_Homo sapiens_hsa052110.29337522
95mTOR signaling pathway_Homo sapiens_hsa041500.28315237
96Parkinsons disease_Homo sapiens_hsa050120.27991915
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27641511
98Ovarian steroidogenesis_Homo sapiens_hsa049130.25688504
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.25367404
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25006992
101Tight junction_Homo sapiens_hsa045300.24904623
102Chemokine signaling pathway_Homo sapiens_hsa040620.24851800
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23621353
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23407353
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23016942
106Hippo signaling pathway_Homo sapiens_hsa043900.22255000
107Endocytosis_Homo sapiens_hsa041440.21816493
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21329388
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20749532
110Insulin signaling pathway_Homo sapiens_hsa049100.19963326
111Protein digestion and absorption_Homo sapiens_hsa049740.18529113
112Regulation of autophagy_Homo sapiens_hsa041400.18400996
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.18363127
114Fatty acid biosynthesis_Homo sapiens_hsa000610.18036372
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.10993200
116beta-Alanine metabolism_Homo sapiens_hsa004100.10714449

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