PLPPR5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a type 2 member of the phosphatidic acid phosphatase (PAP) family. All type 2 members of this protein family contain 6 transmembrane regions, and a consensus N-glycosylation site. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.95693206
2neuron cell-cell adhesion (GO:0007158)5.86539167
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.77275034
4locomotory exploration behavior (GO:0035641)5.71239829
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.66139243
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.47384490
7synaptic vesicle exocytosis (GO:0016079)5.35996398
8synaptic vesicle maturation (GO:0016188)5.14662359
9regulation of glutamate receptor signaling pathway (GO:1900449)5.11198337
10protein localization to synapse (GO:0035418)5.10774475
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.88814534
12glutamate secretion (GO:0014047)4.80180265
13exploration behavior (GO:0035640)4.78278026
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.76975326
15regulation of synaptic vesicle exocytosis (GO:2000300)4.68552244
16regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.65357811
17regulation of synapse structural plasticity (GO:0051823)4.44886266
18neurotransmitter-gated ion channel clustering (GO:0072578)4.44407375
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.42829737
20glutamate receptor signaling pathway (GO:0007215)4.36828955
21presynaptic membrane assembly (GO:0097105)4.35206780
22postsynaptic membrane organization (GO:0001941)4.26181145
23layer formation in cerebral cortex (GO:0021819)4.22154465
24synaptic transmission, glutamatergic (GO:0035249)4.20630842
25neuron-neuron synaptic transmission (GO:0007270)4.20277682
26neurotransmitter secretion (GO:0007269)4.20125976
27neuron recognition (GO:0008038)4.16986928
28nucleobase catabolic process (GO:0046113)4.14492849
29regulation of synaptic vesicle transport (GO:1902803)4.12341315
30positive regulation of synapse maturation (GO:0090129)4.10914995
31regulation of neuronal synaptic plasticity (GO:0048168)4.10262890
32neuronal action potential propagation (GO:0019227)4.07655739
33synaptic vesicle docking involved in exocytosis (GO:0016081)4.07313038
34gamma-aminobutyric acid transport (GO:0015812)3.99425527
35dendritic spine morphogenesis (GO:0060997)3.96012724
36presynaptic membrane organization (GO:0097090)3.91068542
37behavioral response to nicotine (GO:0035095)3.90749530
38positive regulation of membrane potential (GO:0045838)3.88380606
39regulation of excitatory postsynaptic membrane potential (GO:0060079)3.84343615
40long-term memory (GO:0007616)3.81458860
41regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.78962527
42gamma-aminobutyric acid signaling pathway (GO:0007214)3.77890753
43short-term memory (GO:0007614)3.74816029
44behavioral response to ethanol (GO:0048149)3.70180005
45long-term synaptic potentiation (GO:0060291)3.68212139
46innervation (GO:0060384)3.64731685
47regulation of postsynaptic membrane potential (GO:0060078)3.63726046
48regulation of dendritic spine morphogenesis (GO:0061001)3.63340153
49axonal fasciculation (GO:0007413)3.61128044
50response to histamine (GO:0034776)3.55477748
51positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.54784174
52transmission of nerve impulse (GO:0019226)3.54452745
53proline transport (GO:0015824)3.53562458
54negative regulation of synaptic transmission, GABAergic (GO:0032229)3.52522855
55regulation of synaptic plasticity (GO:0048167)3.51459162
56regulation of synaptic transmission, glutamatergic (GO:0051966)3.48515673
57behavioral defense response (GO:0002209)3.42759558
58behavioral fear response (GO:0001662)3.42759558
59neurotransmitter transport (GO:0006836)3.41666064
60secondary heart field specification (GO:0003139)3.40596592
61heart field specification (GO:0003128)3.40596592
62membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.39426862
63synapse assembly (GO:0007416)3.37402269
64positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.35422384
65cellular potassium ion homeostasis (GO:0030007)3.34146674
66positive regulation of dendritic spine development (GO:0060999)3.33836351
67dendrite morphogenesis (GO:0048813)3.32210093
68regulation of dendritic spine development (GO:0060998)3.31045330
69auditory behavior (GO:0031223)3.29826008
70regulation of synapse maturation (GO:0090128)3.29177399
71behavioral response to cocaine (GO:0048148)3.27797335
72C4-dicarboxylate transport (GO:0015740)3.26437588
73positive regulation of synaptic transmission, GABAergic (GO:0032230)3.26261244
74learning (GO:0007612)3.24101331
75fear response (GO:0042596)3.22858051
76regulation of neurotransmitter secretion (GO:0046928)3.21830072
77activation of protein kinase A activity (GO:0034199)3.17274165
78startle response (GO:0001964)3.16263122
79regulation of neurotransmitter levels (GO:0001505)3.15567312
80negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.14648191
81positive regulation of neurotransmitter transport (GO:0051590)3.14395106
82positive regulation of dendritic spine morphogenesis (GO:0061003)3.13889761
83cell migration in hindbrain (GO:0021535)3.12691184
84synaptic vesicle endocytosis (GO:0048488)3.12586771
85cerebellar granule cell differentiation (GO:0021707)3.12584239
86positive regulation of synapse assembly (GO:0051965)3.10972749
87G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.09843311
88establishment of mitochondrion localization (GO:0051654)3.08356262
89membrane hyperpolarization (GO:0060081)3.07668629
90response to auditory stimulus (GO:0010996)3.06437979
91membrane depolarization during action potential (GO:0086010)3.05373640
92social behavior (GO:0035176)3.05238383
93intraspecies interaction between organisms (GO:0051703)3.05238383
94regulation of vesicle fusion (GO:0031338)3.04385356
95central nervous system projection neuron axonogenesis (GO:0021952)3.04373358
96positive regulation of synaptic transmission (GO:0050806)3.03353823
97regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.00982188
98membrane depolarization (GO:0051899)3.00762361
99positive regulation of neurotransmitter secretion (GO:0001956)3.00488464
100synapse organization (GO:0050808)3.00234241
101regulation of synapse assembly (GO:0051963)2.99371941
102regulation of neurotransmitter transport (GO:0051588)2.99102822
103adult walking behavior (GO:0007628)2.98290823
104neuromuscular process controlling balance (GO:0050885)2.97485094
105retinal ganglion cell axon guidance (GO:0031290)2.97022873
106G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.96472255
107pyrimidine nucleobase catabolic process (GO:0006208)2.95565589
108retinal cone cell development (GO:0046549)2.95332136
109regulation of synaptic transmission (GO:0050804)2.93173132
110regulation of synaptic transmission, GABAergic (GO:0032228)2.92853521
111regulation of voltage-gated calcium channel activity (GO:1901385)2.91919999
112righting reflex (GO:0060013)2.91496572
113synaptic transmission (GO:0007268)2.91399819
114mechanosensory behavior (GO:0007638)2.91000093
115serotonin metabolic process (GO:0042428)2.90947149
116negative regulation of neurotransmitter transport (GO:0051589)2.89354218
117detection of calcium ion (GO:0005513)2.87555174
118regulation of glutamate secretion (GO:0014048)2.86529954
119adult behavior (GO:0030534)2.80301065
120spinal cord motor neuron differentiation (GO:0021522)2.80164223
121amino acid import (GO:0043090)2.78221963
122regulation of dopamine secretion (GO:0014059)2.77922778
123acidic amino acid transport (GO:0015800)2.74074166
124neurofilament cytoskeleton organization (GO:0060052)2.72108407

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.07338892
2GBX2_23144817_ChIP-Seq_PC3_Human3.96148855
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.23469498
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.15509639
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08674634
6SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.69994796
7REST_21632747_ChIP-Seq_MESCs_Mouse2.67242837
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.64390520
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.64390520
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60384934
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56933159
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.55691678
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54882141
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.49554782
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47294687
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.34075388
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.28015764
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20756640
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.19719907
20DROSHA_22980978_ChIP-Seq_HELA_Human2.16491613
21AR_21572438_ChIP-Seq_LNCaP_Human2.15637353
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.14487359
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.13575914
24TAF15_26573619_Chip-Seq_HEK293_Human2.11903208
25CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09051307
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.06392645
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.03680546
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99335274
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97236102
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.94289395
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.89677685
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82552897
33SMAD4_21799915_ChIP-Seq_A2780_Human1.73277494
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.69530567
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68652861
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.67643107
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62395366
38P300_19829295_ChIP-Seq_ESCs_Human1.62394519
39ZNF274_21170338_ChIP-Seq_K562_Hela1.47961620
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47063705
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.45644555
42EWS_26573619_Chip-Seq_HEK293_Human1.45460816
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45319865
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44313301
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.42741310
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42153893
47FUS_26573619_Chip-Seq_HEK293_Human1.41212462
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40019517
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40002882
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39796501
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.37973219
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37826449
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37461023
54FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.36939948
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35461648
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35236802
57EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35200621
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.35061051
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.34687550
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.33786247
61AR_25329375_ChIP-Seq_VCAP_Human1.33434070
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30381035
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.27697132
64RING1B_27294783_Chip-Seq_ESCs_Mouse1.27667239
65RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.26468395
66STAT3_23295773_ChIP-Seq_U87_Human1.25752331
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22030985
68RNF2_27304074_Chip-Seq_NSC_Mouse1.21306742
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16892537
70KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16475085
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15500029
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.15317348
73IGF1R_20145208_ChIP-Seq_DFB_Human1.14848141
74TCF4_23295773_ChIP-Seq_U87_Human1.12967864
75AR_19668381_ChIP-Seq_PC3_Human1.12414192
76LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11763326
77P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11423031
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10217025
79STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10009193
80SOX9_26525672_Chip-Seq_HEART_Mouse1.09992313
81ER_23166858_ChIP-Seq_MCF-7_Human1.09723600
82RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09368617
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09030629
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08777932
85AHR_22903824_ChIP-Seq_MCF-7_Human1.08456922
86RING1B_27294783_Chip-Seq_NPCs_Mouse1.07959746
87VDR_22108803_ChIP-Seq_LS180_Human1.07931999
88PRDM14_20953172_ChIP-Seq_ESCs_Human1.07051603
89JUN_21703547_ChIP-Seq_K562_Human1.06638257
90FLI1_27457419_Chip-Seq_LIVER_Mouse1.05774867
91RUNX2_22187159_ChIP-Seq_PCA_Human1.05632533
92YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04945327
93KDM2B_26808549_Chip-Seq_REH_Human1.03555764
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03459460
95CBP_20019798_ChIP-Seq_JUKART_Human1.03276191
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03276191
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02831848
98WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01548039
99ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00367566
100TP53_18474530_ChIP-ChIP_U2OS_Human1.00325362
101BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98814566
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98517497
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98517497
104TAL1_26923725_Chip-Seq_HPCs_Mouse0.98459494
105DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98338339
106CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97144167
107NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96674025
108FLI1_21867929_ChIP-Seq_TH2_Mouse0.96123612
109TP53_16413492_ChIP-PET_HCT116_Human0.95952537
110TCF4_22108803_ChIP-Seq_LS180_Human0.95318682
111P53_22387025_ChIP-Seq_ESCs_Mouse0.95214771
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94607864
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94607019
114POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93945375
115KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93437428
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92913116
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92771306
118NANOG_18555785_Chip-Seq_ESCs_Mouse0.92564482
119SMAD3_21741376_ChIP-Seq_ESCs_Human0.91360431
120BCAT_22108803_ChIP-Seq_LS180_Human0.90781051
121SMAD4_21741376_ChIP-Seq_HESCs_Human0.88068137
122TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87404686
123VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87125581

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.22457958
2MP0003880_abnormal_central_pattern5.23510959
3MP0003635_abnormal_synaptic_transmissio4.20175144
4MP0004270_analgesia3.73519786
5MP0009745_abnormal_behavioral_response3.52219834
6MP0002063_abnormal_learning/memory/cond3.48566483
7MP0002064_seizures3.18708324
8MP0009046_muscle_twitch2.94847966
9MP0002572_abnormal_emotion/affect_behav2.93544327
10MP0001968_abnormal_touch/_nociception2.88351396
11MP0005423_abnormal_somatic_nervous2.78961453
12MP0002822_catalepsy2.63386043
13MP0001486_abnormal_startle_reflex2.62397298
14MP0002734_abnormal_mechanical_nocicepti2.58275086
15MP0002272_abnormal_nervous_system2.53092312
16MP0002736_abnormal_nociception_after2.37342010
17MP0001440_abnormal_grooming_behavior2.37016839
18MP0002735_abnormal_chemical_nociception2.32739912
19MP0001501_abnormal_sleep_pattern2.18533572
20MP0003329_amyloid_beta_deposits2.08548143
21MP0000778_abnormal_nervous_system2.07889611
22MP0002733_abnormal_thermal_nociception1.99561796
23MP0009780_abnormal_chondrocyte_physiolo1.96709328
24MP0002067_abnormal_sensory_capabilities1.93098472
25MP0002184_abnormal_innervation1.89719081
26MP0001970_abnormal_pain_threshold1.87985027
27MP0002557_abnormal_social/conspecific_i1.81113119
28MP0004924_abnormal_behavior1.78716529
29MP0005386_behavior/neurological_phenoty1.78716529
30MP0001529_abnormal_vocalization1.76833873
31MP0006276_abnormal_autonomic_nervous1.74916614
32MP0002751_abnormal_autonomic_nervous1.72798847
33MP0001188_hyperpigmentation1.70185774
34MP0008569_lethality_at_weaning1.68286832
35MP0004811_abnormal_neuron_physiology1.66234454
36MP0003879_abnormal_hair_cell1.64706286
37MP0001984_abnormal_olfaction1.63264782
38MP0004885_abnormal_endolymph1.61986654
39MP0004858_abnormal_nervous_system1.54083496
40MP0006072_abnormal_retinal_apoptosis1.52495912
41MP0003121_genomic_imprinting1.51373987
42MP0000955_abnormal_spinal_cord1.49776792
43MP0005646_abnormal_pituitary_gland1.49465268
44MP0001905_abnormal_dopamine_level1.46058608
45MP0002909_abnormal_adrenal_gland1.45529565
46MP0002882_abnormal_neuron_morphology1.44382255
47MP0002066_abnormal_motor_capabilities/c1.43478563
48MP0004142_abnormal_muscle_tone1.31989070
49MP0002837_dystrophic_cardiac_calcinosis1.28315833
50MP0003787_abnormal_imprinting1.25436203
51MP0005645_abnormal_hypothalamus_physiol1.24034031
52MP0003633_abnormal_nervous_system1.22631986
53MP0003123_paternal_imprinting1.20896407
54MP0002152_abnormal_brain_morphology1.15284495
55MP0001502_abnormal_circadian_rhythm1.14859116
56MP0005253_abnormal_eye_physiology1.10871421
57MP0003631_nervous_system_phenotype1.10007799
58MP0004742_abnormal_vestibular_system1.05565714
59MP0005551_abnormal_eye_electrophysiolog1.05452556
60MP0008877_abnormal_DNA_methylation1.03714012
61MP0002229_neurodegeneration0.99478214
62MP0000604_amyloidosis0.98745087
63MP0009379_abnormal_foot_pigmentation0.97531430
64MP0003122_maternal_imprinting0.96175409
65MP0001963_abnormal_hearing_physiology0.95899761
66MP0002069_abnormal_eating/drinking_beha0.93648384
67MP0000751_myopathy0.92991549
68MP0004133_heterotaxia0.91733624
69MP0000569_abnormal_digit_pigmentation0.91605854
70MP0000920_abnormal_myelination0.89920622
71MP0002876_abnormal_thyroid_physiology0.89895332
72MP0004085_abnormal_heartbeat0.89556943
73MP0003634_abnormal_glial_cell0.89533266
74MP0006292_abnormal_olfactory_placode0.89301867
75MP0004215_abnormal_myocardial_fiber0.87839339
76MP0000049_abnormal_middle_ear0.86342608
77MP0000631_abnormal_neuroendocrine_gland0.86253226
78MP0003632_abnormal_nervous_system0.85022602
79MP0002752_abnormal_somatic_nervous0.84542836
80MP0000013_abnormal_adipose_tissue0.83958480
81MP0001177_atelectasis0.83509820
82MP0010386_abnormal_urinary_bladder0.82415541
83MP0008872_abnormal_physiological_respon0.82086550
84MP0003567_abnormal_fetal_cardiomyocyte0.81674111
85MP0002234_abnormal_pharynx_morphology0.80517803
86MP0004145_abnormal_muscle_electrophysio0.80130938
87MP0003690_abnormal_glial_cell0.78438305
88MP0004484_altered_response_of0.78333064
89MP0008874_decreased_physiological_sensi0.78305831
90MP0005409_darkened_coat_color0.78139199
91MP0002233_abnormal_nose_morphology0.76724232
92MP0002638_abnormal_pupillary_reflex0.76189173
93MP0005499_abnormal_olfactory_system0.75874108
94MP0005394_taste/olfaction_phenotype0.75874108
95MP0005187_abnormal_penis_morphology0.74192346
96MP0003890_abnormal_embryonic-extraembry0.73416994
97MP0005171_absent_coat_pigmentation0.73036149
98MP0003136_yellow_coat_color0.72616287
99MP0005248_abnormal_Harderian_gland0.71204386
100MP0003119_abnormal_digestive_system0.71201804
101MP0001485_abnormal_pinna_reflex0.70788398
102MP0001299_abnormal_eye_distance/0.70744696
103MP0002090_abnormal_vision0.70629769
104MP0005535_abnormal_body_temperature0.70447021
105MP0003011_delayed_dark_adaptation0.69006156
106MP0005195_abnormal_posterior_eye0.68376734
107MP0003938_abnormal_ear_development0.68001750
108MP0008789_abnormal_olfactory_epithelium0.67373872
109MP0003137_abnormal_impulse_conducting0.66926452
110MP0000026_abnormal_inner_ear0.62996417
111MP0001664_abnormal_digestion0.60331188
112MP0003861_abnormal_nervous_system0.60300539
113MP0004233_abnormal_muscle_weight0.58805691
114MP0004510_myositis0.57616622
115MP0003075_altered_response_to0.54944337
116MP0010770_preweaning_lethality0.53154425
117MP0002082_postnatal_lethality0.53154425
118MP0002102_abnormal_ear_morphology0.52857323
119MP0005623_abnormal_meninges_morphology0.52778080
120MP0001943_abnormal_respiration0.52600168
121MP0010769_abnormal_survival0.52426473
122MP0003956_abnormal_body_size0.49790495
123MP0001348_abnormal_lacrimal_gland0.49284613
124MP0010768_mortality/aging0.48671611

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.79490585
2Myokymia (HP:0002411)5.82031607
3Focal seizures (HP:0007359)5.52969647
4Epileptic encephalopathy (HP:0200134)5.15527270
5Visual hallucinations (HP:0002367)4.92668460
6Atonic seizures (HP:0010819)4.70126492
7Hyperventilation (HP:0002883)4.50481794
8Febrile seizures (HP:0002373)4.20972423
9Absence seizures (HP:0002121)4.13658703
10Progressive cerebellar ataxia (HP:0002073)3.86444067
11Dialeptic seizures (HP:0011146)3.82514189
12Broad-based gait (HP:0002136)3.79615503
13Generalized tonic-clonic seizures (HP:0002069)3.78405254
14Mutism (HP:0002300)3.49024221
15Supranuclear gaze palsy (HP:0000605)3.44296323
16Neurofibrillary tangles (HP:0002185)3.40024871
17Cerebral inclusion bodies (HP:0100314)3.37001889
18Abnormality of the corticospinal tract (HP:0002492)3.26964332
19Progressive inability to walk (HP:0002505)3.25733190
20Excessive salivation (HP:0003781)3.25561065
21Drooling (HP:0002307)3.25561065
22Impaired vibration sensation in the lower limbs (HP:0002166)3.24734628
23Poor eye contact (HP:0000817)3.22722257
24Insidious onset (HP:0003587)3.09305348
25Termporal pattern (HP:0011008)3.09305348
26Abnormal eating behavior (HP:0100738)2.99644321
27Action tremor (HP:0002345)2.99167139
28Impaired social interactions (HP:0000735)2.98972583
29Abnormal social behavior (HP:0012433)2.98972583
30Urinary bladder sphincter dysfunction (HP:0002839)2.98900185
31Amblyopia (HP:0000646)2.97883583
32Dysdiadochokinesis (HP:0002075)2.95999866
33Ankle clonus (HP:0011448)2.94028641
34Polyphagia (HP:0002591)2.88565333
35Diplopia (HP:0000651)2.87827794
36Abnormality of binocular vision (HP:0011514)2.87827794
37Inability to walk (HP:0002540)2.85911762
38Gaze-evoked nystagmus (HP:0000640)2.85729078
39Type II lissencephaly (HP:0007260)2.84503292
40Dysmetria (HP:0001310)2.77326021
41Epileptiform EEG discharges (HP:0011182)2.77160267
42Anxiety (HP:0000739)2.73916218
43Absent speech (HP:0001344)2.73344669
44Truncal ataxia (HP:0002078)2.72484404
45Depression (HP:0000716)2.70074477
46Akinesia (HP:0002304)2.68790293
47Hemiparesis (HP:0001269)2.68520936
48Spastic gait (HP:0002064)2.66852193
49Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.64242786
50Degeneration of the lateral corticospinal tracts (HP:0002314)2.64242786
51Amyotrophic lateral sclerosis (HP:0007354)2.64129199
52EEG with generalized epileptiform discharges (HP:0011198)2.63910069
53Lissencephaly (HP:0001339)2.62028552
54Papilledema (HP:0001085)2.59123261
55Urinary urgency (HP:0000012)2.57889765
56Limb dystonia (HP:0002451)2.56584205
57Stereotypic behavior (HP:0000733)2.54839320
58Genital tract atresia (HP:0001827)2.52450070
59Hypsarrhythmia (HP:0002521)2.51394020
60Spastic tetraplegia (HP:0002510)2.48674928
61Congenital primary aphakia (HP:0007707)2.47619862
62Vaginal atresia (HP:0000148)2.42907231
63Optic nerve hypoplasia (HP:0000609)2.42848387
64Postural instability (HP:0002172)2.42831582
65Pheochromocytoma (HP:0002666)2.40708132
66Medial flaring of the eyebrow (HP:0010747)2.39276873
67Generalized myoclonic seizures (HP:0002123)2.36617960
68Cerebellar dysplasia (HP:0007033)2.34988854
69Genetic anticipation (HP:0003743)2.34437784
70Fetal akinesia sequence (HP:0001989)2.31047846
71Abnormality of the labia minora (HP:0012880)2.30461641
72Torticollis (HP:0000473)2.30055843
73Nephrogenic diabetes insipidus (HP:0009806)2.29008995
74Septo-optic dysplasia (HP:0100842)2.28841531
75Scanning speech (HP:0002168)2.27659599
76Protruding tongue (HP:0010808)2.27304330
77Bradykinesia (HP:0002067)2.26904442
78Blue irides (HP:0000635)2.26489391
79Gait imbalance (HP:0002141)2.25580509
80Focal dystonia (HP:0004373)2.24579188
81Lower limb muscle weakness (HP:0007340)2.23474671
82Intention tremor (HP:0002080)2.21740559
83Megalencephaly (HP:0001355)2.19969416
84Esotropia (HP:0000565)2.17922773
85Hypothermia (HP:0002045)2.17239810
86Thickened helices (HP:0000391)2.17119542
87Abnormality of salivation (HP:0100755)2.16983150
88Neuroendocrine neoplasm (HP:0100634)2.14079924
89Impaired smooth pursuit (HP:0007772)2.08300000
90Inappropriate behavior (HP:0000719)2.07782201
91Hepatoblastoma (HP:0002884)2.05767072
92Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.05573903
93Pachygyria (HP:0001302)2.04911883
94Impaired vibratory sensation (HP:0002495)2.04573547
95Retinal dysplasia (HP:0007973)2.04460949
96Abolished electroretinogram (ERG) (HP:0000550)2.02702321
97Status epilepticus (HP:0002133)2.02029556
98Craniofacial dystonia (HP:0012179)2.01711406
99Exotropia (HP:0000577)2.00943180
100Abnormality of the lower motor neuron (HP:0002366)2.00605203
101Poor suck (HP:0002033)1.98037977
102Hemiplegia (HP:0002301)1.93090420
103Broad foot (HP:0001769)1.90941311
104Muscular hypotonia of the trunk (HP:0008936)1.89735449
105Intestinal atresia (HP:0011100)1.89441144
106Neuronal loss in central nervous system (HP:0002529)1.88890259
107Hypoplasia of the corpus callosum (HP:0002079)1.88246920
108Acute necrotizing encephalopathy (HP:0006965)1.87177331
109Morphological abnormality of the pyramidal tract (HP:0002062)1.85145777
110Obstructive sleep apnea (HP:0002870)1.84427958
111Aqueductal stenosis (HP:0002410)1.83440463
112Specific learning disability (HP:0001328)1.83296034
113Neoplasm of the peripheral nervous system (HP:0100007)1.82490599
114Split foot (HP:0001839)1.82315185
115Delusions (HP:0000746)1.81107474
116Poor coordination (HP:0002370)1.81057540
117Gait ataxia (HP:0002066)1.80366870
118Polymicrogyria (HP:0002126)1.80232258
119Apathy (HP:0000741)1.78884520
120Hyperthyroidism (HP:0000836)1.78718509
121Intellectual disability, severe (HP:0010864)1.77411302
122Agitation (HP:0000713)1.76072527
123Nephronophthisis (HP:0000090)1.75790323
124Psychosis (HP:0000709)1.75718696
125Abnormality of ocular smooth pursuit (HP:0000617)1.74456530
126Decreased testicular size (HP:0008734)1.74419150
127Athetosis (HP:0002305)1.74070392
128Progressive macrocephaly (HP:0004481)1.73485551
129Generalized hypopigmentation of hair (HP:0011358)1.72380654
130Aplasia/Hypoplasia of the brainstem (HP:0007362)1.72379792
131Hypoplasia of the brainstem (HP:0002365)1.72379792
132Sleep apnea (HP:0010535)1.72006506
133Peripheral hypomyelination (HP:0007182)1.68033250
134Ulnar claw (HP:0001178)1.63400255

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.59327709
2NTRK33.95640914
3EPHA43.93503003
4MAP3K93.52933477
5CASK3.07217888
6MAP3K42.92628788
7EPHA32.77120058
8MAP2K72.65734615
9MINK12.60310277
10NTRK22.23649178
11DAPK22.19168895
12RIPK41.94179963
13PAK61.92080795
14MAP3K121.87797045
15MAP2K41.82634416
16PNCK1.72872074
17KSR21.71837844
18TNIK1.70429300
19PLK21.68715721
20MAP4K21.68326901
21NTRK11.67659503
22KSR11.64559021
23CAMKK21.64356841
24CAMKK11.60316773
25MAPK131.52446325
26DAPK11.47500518
27CDK51.46517289
28ARAF1.41223276
29MKNK21.40102529
30GRK51.36418765
31CDK191.33504926
32PHKG21.30689602
33PHKG11.30689602
34SIK21.25708838
35TRIM281.21363809
36FES1.21314601
37PRKCG1.20373744
38AKT31.17552816
39CSNK1G11.17290409
40PRPF4B1.12072952
41OXSR11.09196109
42CAMK2A1.08003736
43LATS21.07573135
44PRKD31.04009622
45CAMK1G1.03927410
46CAMK2B0.94216675
47MAP3K130.94123267
48BMPR20.91047686
49TYRO30.90979312
50UHMK10.90198185
51MAP3K20.88250464
52CSNK1G20.88158682
53CSNK1A1L0.86679228
54NME10.86166904
55CDK180.85441468
56CDK140.84872478
57CDK150.83036065
58CAMK10.80579541
59PAK30.79001643
60RAF10.78761295
61DYRK1A0.78215266
62FRK0.77985596
63SGK2230.77246183
64SGK4940.77246183
65PTK2B0.76384813
66PKN10.75064567
67ADRBK20.74470900
68STK110.72546432
69STK380.71738393
70DYRK30.71395450
71CDK11A0.71208991
72PLK40.66979348
73LIMK10.66486053
74MAP3K60.65368982
75PRKCE0.65153519
76STK390.63335118
77DYRK20.63228023
78SGK20.63101557
79MKNK10.62637940
80MARK20.62477866
81SGK10.62378300
82CCNB10.61222437
83MAPK120.59839808
84BMPR1B0.59821357
85WNK40.58918239
86TAOK10.58665432
87RET0.58500398
88BRAF0.56575911
89PRKCZ0.55543831
90CAMK2D0.55081931
91CSNK1D0.54249346
92PRKCH0.53126628
93INSRR0.52799192
94FGR0.52718544
95DMPK0.52015678
96CSNK1E0.52008599
97BCR0.49330525
98FYN0.48573305
99PDPK10.47663550
100CAMK1D0.46823194
101CAMK2G0.45480698
102PRKG10.45009951
103PRKACA0.44525820
104GRK10.44252023
105PDK10.43059131
106SGK30.41843724
107PDK30.40571132
108PDK40.40571132
109CDK30.39644605
110WNK30.39425657
111RPS6KA30.38178053
112FGFR20.38086719
113CSNK1A10.37584430
114CAMK40.36891331
115GRK70.36659739
116ERBB30.36381501
117RPS6KA50.35917796
118PINK10.35407727
119ROCK20.35291240
120CSNK1G30.34983622
121FER0.34644310
122MAP2K10.33910943
123MAP2K60.32916433
124DAPK30.32894952
125EPHB20.31880063
126MAPK100.31811592
127ERBB40.31076933
128PRKCB0.31040163
129PRKDC0.30914075
130RPS6KA40.30878650
131PRKACB0.29778874
132PRKCA0.26041626
133BCKDK0.25089412
134GSK3B0.24764644

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.94041528
2Synaptic vesicle cycle_Homo sapiens_hsa047213.26500330
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.85891002
4GABAergic synapse_Homo sapiens_hsa047272.80367868
5Long-term potentiation_Homo sapiens_hsa047202.72859722
6Circadian entrainment_Homo sapiens_hsa047132.66984804
7Glutamatergic synapse_Homo sapiens_hsa047242.62566585
8Morphine addiction_Homo sapiens_hsa050322.59959807
9Olfactory transduction_Homo sapiens_hsa047402.53385160
10Amphetamine addiction_Homo sapiens_hsa050312.37702276
11Dopaminergic synapse_Homo sapiens_hsa047282.26873778
12Salivary secretion_Homo sapiens_hsa049702.13866894
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.06325214
14Collecting duct acid secretion_Homo sapiens_hsa049661.94271704
15Cholinergic synapse_Homo sapiens_hsa047251.91757844
16Serotonergic synapse_Homo sapiens_hsa047261.89570154
17Long-term depression_Homo sapiens_hsa047301.88730016
18Renin secretion_Homo sapiens_hsa049241.79636825
19Taste transduction_Homo sapiens_hsa047421.78240242
20Gastric acid secretion_Homo sapiens_hsa049711.77468181
21Insulin secretion_Homo sapiens_hsa049111.74128311
22Protein export_Homo sapiens_hsa030601.70304284
23Oxytocin signaling pathway_Homo sapiens_hsa049211.65706830
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64570578
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57477043
26Calcium signaling pathway_Homo sapiens_hsa040201.53677876
27Cocaine addiction_Homo sapiens_hsa050301.51675903
28Axon guidance_Homo sapiens_hsa043601.41381350
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.38663312
30Gap junction_Homo sapiens_hsa045401.35369903
31GnRH signaling pathway_Homo sapiens_hsa049121.33783815
32Cardiac muscle contraction_Homo sapiens_hsa042601.23051072
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22106766
34Vibrio cholerae infection_Homo sapiens_hsa051101.19738181
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18569774
36cAMP signaling pathway_Homo sapiens_hsa040241.18058771
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14810778
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11411291
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10159563
40Estrogen signaling pathway_Homo sapiens_hsa049151.09881850
41Glioma_Homo sapiens_hsa052141.05642736
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05461993
43Phototransduction_Homo sapiens_hsa047441.03741743
44Melanogenesis_Homo sapiens_hsa049161.03356565
45Oxidative phosphorylation_Homo sapiens_hsa001901.00782946
46ErbB signaling pathway_Homo sapiens_hsa040120.99415193
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97654957
48Alzheimers disease_Homo sapiens_hsa050100.96393168
49Type II diabetes mellitus_Homo sapiens_hsa049300.93605032
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93247004
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.91359131
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90038243
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89824872
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88294758
55Oocyte meiosis_Homo sapiens_hsa041140.81096158
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81083715
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76294184
58Dorso-ventral axis formation_Homo sapiens_hsa043200.75793754
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74238975
60Pancreatic secretion_Homo sapiens_hsa049720.72364724
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.71963085
62Fatty acid biosynthesis_Homo sapiens_hsa000610.71324909
63Dilated cardiomyopathy_Homo sapiens_hsa054140.70048216
64Parkinsons disease_Homo sapiens_hsa050120.68694110
65Choline metabolism in cancer_Homo sapiens_hsa052310.68071352
66MAPK signaling pathway_Homo sapiens_hsa040100.67563084
67Nitrogen metabolism_Homo sapiens_hsa009100.67216454
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66884002
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66696928
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66510900
71Thyroid hormone synthesis_Homo sapiens_hsa049180.66176647
72Steroid biosynthesis_Homo sapiens_hsa001000.64602262
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62672993
74Ras signaling pathway_Homo sapiens_hsa040140.61568898
75Hippo signaling pathway_Homo sapiens_hsa043900.60643508
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60484011
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59563485
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56048301
79VEGF signaling pathway_Homo sapiens_hsa043700.54836011
80Butanoate metabolism_Homo sapiens_hsa006500.54768244
81Alcoholism_Homo sapiens_hsa050340.54249887
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53820740
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.52057155
84Renal cell carcinoma_Homo sapiens_hsa052110.52015282
85Type I diabetes mellitus_Homo sapiens_hsa049400.50978455
86Rap1 signaling pathway_Homo sapiens_hsa040150.50975157
87Glucagon signaling pathway_Homo sapiens_hsa049220.50190699
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48039135
89Huntingtons disease_Homo sapiens_hsa050160.46692665
90Circadian rhythm_Homo sapiens_hsa047100.46125163
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.45132773
92Prion diseases_Homo sapiens_hsa050200.45075657
93beta-Alanine metabolism_Homo sapiens_hsa004100.43610397
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43338442
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43199119
96Basal transcription factors_Homo sapiens_hsa030220.43039498
97Endometrial cancer_Homo sapiens_hsa052130.40750660
98Wnt signaling pathway_Homo sapiens_hsa043100.40553131
99Vitamin B6 metabolism_Homo sapiens_hsa007500.38857910
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38725252
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38186804
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38179018
103Rheumatoid arthritis_Homo sapiens_hsa053230.37572329
104African trypanosomiasis_Homo sapiens_hsa051430.36889142
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36780656
106Tight junction_Homo sapiens_hsa045300.36694254
107Hedgehog signaling pathway_Homo sapiens_hsa043400.36679535
108Bile secretion_Homo sapiens_hsa049760.36102547
109Endocytosis_Homo sapiens_hsa041440.33828136
110Ovarian steroidogenesis_Homo sapiens_hsa049130.33430060
111mTOR signaling pathway_Homo sapiens_hsa041500.32926564
112Non-small cell lung cancer_Homo sapiens_hsa052230.32796043
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32545990
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32442405
115Insulin signaling pathway_Homo sapiens_hsa049100.31910131
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30629435
117Inositol phosphate metabolism_Homo sapiens_hsa005620.28803147
118Chemokine signaling pathway_Homo sapiens_hsa040620.28306171
119Colorectal cancer_Homo sapiens_hsa052100.27786039
120Propanoate metabolism_Homo sapiens_hsa006400.26899416
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26549731
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26319460
123Ether lipid metabolism_Homo sapiens_hsa005650.25968102
124Selenocompound metabolism_Homo sapiens_hsa004500.24382037
125Peroxisome_Homo sapiens_hsa041460.24061658
126RNA polymerase_Homo sapiens_hsa030200.23806835

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