PLRG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a core component of the cell division cycle 5-like (CDC5L) complex. The CDC5L complex is part of the spliceosome and is required for pre-mRNA splicing. The encoded protein plays a critical role in alternative splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)4.78193414
2protein localization to kinetochore (GO:0034501)4.78002990
3DNA strand elongation involved in DNA replication (GO:0006271)4.71254436
4DNA replication initiation (GO:0006270)4.70800870
5DNA unwinding involved in DNA replication (GO:0006268)4.66347380
6maturation of SSU-rRNA (GO:0030490)4.59656266
7DNA strand elongation (GO:0022616)4.47623419
8telomere maintenance via semi-conservative replication (GO:0032201)4.36797992
9purine nucleobase biosynthetic process (GO:0009113)4.28814049
10nucleobase biosynthetic process (GO:0046112)4.27680971
11formation of translation preinitiation complex (GO:0001731)4.24235643
12establishment of viral latency (GO:0019043)4.22528837
13metaphase plate congression (GO:0051310)4.15258663
14IMP biosynthetic process (GO:0006188)4.12518251
15ribosomal small subunit assembly (GO:0000028)4.11294079
16DNA replication checkpoint (GO:0000076)4.07284924
17DNA replication-dependent nucleosome assembly (GO:0006335)4.06711552
18DNA replication-dependent nucleosome organization (GO:0034723)4.06711552
19DNA ligation (GO:0006266)4.06482354
20folic acid-containing compound biosynthetic process (GO:0009396)4.04746348
21CENP-A containing nucleosome assembly (GO:0034080)3.98544971
22mitotic nuclear envelope disassembly (GO:0007077)3.97499256
23protein localization to chromosome, centromeric region (GO:0071459)3.96516189
24ribosome assembly (GO:0042255)3.94665638
25telomere maintenance via recombination (GO:0000722)3.94427894
26chromatin remodeling at centromere (GO:0031055)3.92645173
27attachment of spindle microtubules to kinetochore (GO:0008608)3.82849394
28mitotic recombination (GO:0006312)3.80421808
29ribosome biogenesis (GO:0042254)3.76931800
30membrane disassembly (GO:0030397)3.68258485
31nuclear envelope disassembly (GO:0051081)3.68258485
32DNA replication-independent nucleosome assembly (GO:0006336)3.68088488
33DNA replication-independent nucleosome organization (GO:0034724)3.68088488
34establishment of chromosome localization (GO:0051303)3.66964008
35regulation of spindle organization (GO:0090224)3.66650946
36mitotic chromosome condensation (GO:0007076)3.66426545
37nuclear pore organization (GO:0006999)3.64489861
38DNA double-strand break processing (GO:0000729)3.64290888
39IMP metabolic process (GO:0046040)3.63574105
40kinetochore organization (GO:0051383)3.60835171
41ribonucleoprotein complex biogenesis (GO:0022613)3.56115644
42mitotic sister chromatid segregation (GO:0000070)3.55821790
43spliceosomal snRNP assembly (GO:0000387)3.55383631
44telomere maintenance via telomere lengthening (GO:0010833)3.53268446
45regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.51649049
46ribosomal large subunit biogenesis (GO:0042273)3.49664398
47cullin deneddylation (GO:0010388)3.47991998
48positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.47318154
49anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.47248722
50protein deneddylation (GO:0000338)3.46831825
51double-strand break repair via nonhomologous end joining (GO:0006303)3.44930247
52non-recombinational repair (GO:0000726)3.44930247
53nucleotide-excision repair, DNA gap filling (GO:0006297)3.44483207
54tRNA aminoacylation for protein translation (GO:0006418)3.43469605
55regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.42438572
56histone exchange (GO:0043486)3.41210201
57amino acid activation (GO:0043038)3.37785016
58tRNA aminoacylation (GO:0043039)3.37785016
59regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.36709674
60negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.36426616
61viral transcription (GO:0019083)3.35335248
62translational termination (GO:0006415)3.35279076
63spindle checkpoint (GO:0031577)3.35186835
64kinetochore assembly (GO:0051382)3.34505956
65regulation of centriole replication (GO:0046599)3.34242310
66rRNA processing (GO:0006364)3.34102143
67positive regulation of ligase activity (GO:0051351)3.33446477
68establishment of protein localization to mitochondrial membrane (GO:0090151)3.33392314
69negative regulation of chromosome segregation (GO:0051985)3.31943166
70negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.31437540
71negative regulation of sister chromatid segregation (GO:0033046)3.31437540
72negative regulation of mitotic sister chromatid separation (GO:2000816)3.31437540
73negative regulation of mitotic sister chromatid segregation (GO:0033048)3.31437540
74DNA deamination (GO:0045006)3.30390887
75positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.30223255
76mitotic spindle assembly checkpoint (GO:0007094)3.29537786
77mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.29477273
78spindle assembly checkpoint (GO:0071173)3.28544023
79regulation of ubiquitin-protein transferase activity (GO:0051438)3.28334694
80translational initiation (GO:0006413)3.26176333
81negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.25527423
82sister chromatid segregation (GO:0000819)3.25289601
83ribosomal small subunit biogenesis (GO:0042274)3.25061395
84rRNA metabolic process (GO:0016072)3.22697796
85L-serine metabolic process (GO:0006563)3.22099719
86regulation of chromosome segregation (GO:0051983)3.21082242
87regulation of cellular amino acid metabolic process (GO:0006521)3.20825554
88postreplication repair (GO:0006301)3.20561699
89mitotic spindle checkpoint (GO:0071174)3.20518332
90signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.19674233
91signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.19674233
92signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.19674233
93spliceosomal complex assembly (GO:0000245)3.18805568
94DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.17659740
95regulation of ligase activity (GO:0051340)3.17424364
96DNA catabolic process, exonucleolytic (GO:0000738)3.17052798
97nuclear pore complex assembly (GO:0051292)3.16710276
98intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.16421954
99signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.16421954
100translesion synthesis (GO:0019985)3.15987655
101translational elongation (GO:0006414)3.15505144
102transcription-coupled nucleotide-excision repair (GO:0006283)3.14222503
103DNA damage response, detection of DNA damage (GO:0042769)3.12997831
104signal transduction involved in DNA damage checkpoint (GO:0072422)3.12918986
105signal transduction involved in DNA integrity checkpoint (GO:0072401)3.12918986
106proteasome assembly (GO:0043248)3.12050336
107regulation of mitotic metaphase/anaphase transition (GO:0030071)3.11938582
108meiotic chromosome segregation (GO:0045132)3.11487293
109signal transduction involved in cell cycle checkpoint (GO:0072395)3.10831961
110positive regulation of chromosome segregation (GO:0051984)3.10417048
111regulation of helicase activity (GO:0051095)3.09086747
112negative regulation of ligase activity (GO:0051352)3.08353181
113negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.08353181
114regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.07814831
115negative regulation of DNA-templated transcription, elongation (GO:0032785)3.06410387
116negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.06410387
117cell cycle G1/S phase transition (GO:0044843)3.06330024
118G1/S transition of mitotic cell cycle (GO:0000082)3.06330024
119regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.05922353
120regulation of mitotic spindle checkpoint (GO:1903504)3.05922353
121establishment of integrated proviral latency (GO:0075713)3.04478326
122exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.03259553
123protein K11-linked ubiquitination (GO:0070979)3.02629473
124mismatch repair (GO:0006298)3.02012188
125nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.01776507
126protein K6-linked ubiquitination (GO:0085020)3.01514897
127rRNA modification (GO:0000154)3.01069127
128DNA duplex unwinding (GO:0032508)3.01056625
129DNA geometric change (GO:0032392)3.00239819
130regulation of mitotic spindle organization (GO:0060236)2.99666998
131regulation of sister chromatid segregation (GO:0033045)2.99095872
132regulation of mitotic sister chromatid separation (GO:0010965)2.99095872
133regulation of mitotic sister chromatid segregation (GO:0033047)2.99095872
134somatic diversification of immune receptors via somatic mutation (GO:0002566)2.98662549
135somatic hypermutation of immunoglobulin genes (GO:0016446)2.98662549
136histone mRNA metabolic process (GO:0008334)2.97815987
137nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.94696507

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.25657114
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.43240864
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.02931239
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.72336514
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.64620952
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.48038794
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.22881036
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.10921377
9* GABP_17652178_ChIP-ChIP_JURKAT_Human3.09723615
10MYC_19079543_ChIP-ChIP_MESCs_Mouse3.04126470
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.95354484
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.92582007
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.91947733
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.90090122
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.79450775
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.69352240
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.61308532
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.60244975
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.44409248
20XRN2_22483619_ChIP-Seq_HELA_Human2.43498464
21AR_21909140_ChIP-Seq_LNCAP_Human2.43169753
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.39012526
23VDR_23849224_ChIP-Seq_CD4+_Human2.30517760
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.15688707
25FOXP3_21729870_ChIP-Seq_TREG_Human2.05141332
26DCP1A_22483619_ChIP-Seq_HELA_Human2.03626183
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.02537272
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.01072009
29* GABP_19822575_ChIP-Seq_HepG2_Human1.97449738
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.95912249
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.94313455
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.93238431
33TTF2_22483619_ChIP-Seq_HELA_Human1.93177326
34* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91374928
35KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.88766074
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87993231
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.85252746
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77169195
39ELK1_19687146_ChIP-ChIP_HELA_Human1.74012971
40RBPJ_22232070_ChIP-Seq_NCS_Mouse1.70976583
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70556592
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.68702030
43CIITA_25753668_ChIP-Seq_RAJI_Human1.64596163
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.63768730
45* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62404665
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61869094
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61832239
48* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60775510
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.55003848
50* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.50323263
51* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49601882
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.47138665
53EWS_26573619_Chip-Seq_HEK293_Human1.46154384
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45445506
55KDM5A_27292631_Chip-Seq_BREAST_Human1.42829046
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39333942
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39108977
58FUS_26573619_Chip-Seq_HEK293_Human1.38479763
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37903480
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.36346133
61PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34878739
62MYC_22102868_ChIP-Seq_BL_Human1.34505209
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31629194
64* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29438215
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28293879
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.25410938
67NANOG_16153702_ChIP-ChIP_HESCs_Human1.24599917
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22003437
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.21110226
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20996187
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.20715080
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20564684
73* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20007294
74TFEB_21752829_ChIP-Seq_HELA_Human1.19801049
75E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18685923
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17469362
77SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.17079297
78CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.16766735
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12794632
80KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12794415
81SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12232082
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11669442
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07214229
84MYC_18940864_ChIP-ChIP_HL60_Human1.06883326
85SOX2_16153702_ChIP-ChIP_HESCs_Human1.06626874
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06435958
87* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05998356
88* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05400975
89* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04653794
90STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03636494
91WT1_19549856_ChIP-ChIP_CCG9911_Human1.03523265
92NOTCH1_21737748_ChIP-Seq_TLL_Human1.01076782
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00811676
94ELK1_22589737_ChIP-Seq_MCF10A_Human0.99962505
95SALL1_21062744_ChIP-ChIP_HESCs_Human0.99949622
96BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98401808
97HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95633806
98ZNF274_21170338_ChIP-Seq_K562_Hela0.94247608
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93094540
100SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92767204
101HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91165354
102* NANOG_21062744_ChIP-ChIP_HESCs_Human0.91107729
103KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90914946
104PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90900845
105CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90107150
106CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89532344
107TCF3_18692474_ChIP-Seq_MEFs_Mouse0.89305759
108* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89230110
109IGF1R_20145208_ChIP-Seq_DFB_Human0.89127523
110SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.87959016
111TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85629472
112VDR_22108803_ChIP-Seq_LS180_Human0.83253598
113GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83193052
114SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83062201
115SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81366744
116OCT4_18692474_ChIP-Seq_MEFs_Mouse0.80553306
117PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.77150033
118DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.76323142
119SOX17_20123909_ChIP-Seq_XEN_Mouse0.73396308
120HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.72401962
121IRF1_19129219_ChIP-ChIP_H3396_Human0.72305647
122P300_19829295_ChIP-Seq_ESCs_Human0.70525113
123CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.68886897
124TAF15_26573619_Chip-Seq_HEK293_Human0.68266333
125* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.68014009

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.60478184
2MP0010094_abnormal_chromosome_stability4.96324583
3MP0004957_abnormal_blastocyst_morpholog4.60257130
4MP0003111_abnormal_nucleus_morphology4.41958371
5* MP0003077_abnormal_cell_cycle4.27392435
6MP0008057_abnormal_DNA_replication3.92056134
7MP0003123_paternal_imprinting3.62925903
8MP0008058_abnormal_DNA_repair3.49378838
9MP0003941_abnormal_skin_development3.00085898
10MP0008007_abnormal_cellular_replicative3.00073705
11MP0008932_abnormal_embryonic_tissue2.95914736
12MP0001730_embryonic_growth_arrest2.59721660
13MP0008877_abnormal_DNA_methylation2.54684188
14* MP0000350_abnormal_cell_proliferation2.39032151
15MP0003786_premature_aging2.16095594
16MP0003718_maternal_effect2.02930357
17MP0010352_gastrointestinal_tract_polyps1.93183929
18MP0003121_genomic_imprinting1.90704748
19MP0010307_abnormal_tumor_latency1.85102071
20MP0001672_abnormal_embryogenesis/_devel1.82002771
21MP0005380_embryogenesis_phenotype1.82002771
22MP0001697_abnormal_embryo_size1.78181593
23MP0003890_abnormal_embryonic-extraembry1.75506940
24MP0000537_abnormal_urethra_morphology1.74078070
25MP0002653_abnormal_ependyma_morphology1.72726040
26MP0002396_abnormal_hematopoietic_system1.71892961
27MP0010030_abnormal_orbit_morphology1.69089746
28* MP0002080_prenatal_lethality1.67142351
29MP0002085_abnormal_embryonic_tissue1.66870012
30MP0002084_abnormal_developmental_patter1.61357583
31MP0000490_abnormal_crypts_of1.58900726
32MP0006035_abnormal_mitochondrial_morpho1.57566369
33MP0003984_embryonic_growth_retardation1.56401981
34MP0002088_abnormal_embryonic_growth/wei1.54594597
35MP0004808_abnormal_hematopoietic_stem1.50064149
36MP0002233_abnormal_nose_morphology1.49384274
37MP0002210_abnormal_sex_determination1.47704990
38MP0000313_abnormal_cell_death1.43027046
39MP0004197_abnormal_fetal_growth/weight/1.41535844
40MP0003315_abnormal_perineum_morphology1.37465280
41MP0003806_abnormal_nucleotide_metabolis1.36893396
42MP0005394_taste/olfaction_phenotype1.33492125
43MP0005499_abnormal_olfactory_system1.33492125
44MP0002086_abnormal_extraembryonic_tissu1.32629246
45MP0002019_abnormal_tumor_incidence1.32472548
46MP0003567_abnormal_fetal_cardiomyocyte1.30942315
47MP0000372_irregular_coat_pigmentation1.30342651
48MP0006036_abnormal_mitochondrial_physio1.26635924
49MP0001145_abnormal_male_reproductive1.24090254
50MP0001929_abnormal_gametogenesis1.22552114
51MP0001293_anophthalmia1.21804233
52MP0002234_abnormal_pharynx_morphology1.21509458
53MP0002697_abnormal_eye_size1.21456432
54MP0006072_abnormal_retinal_apoptosis1.20425534
55MP0003119_abnormal_digestive_system1.20043770
56MP0009053_abnormal_anal_canal1.19746117
57MP0000653_abnormal_sex_gland1.11886828
58MP0004133_heterotaxia1.07872052
59MP0003950_abnormal_plasma_membrane1.07008363
60MP0003385_abnormal_body_wall1.05567898
61MP0009697_abnormal_copulation1.03226989
62MP0001299_abnormal_eye_distance/1.02776585
63MP0003937_abnormal_limbs/digits/tail_de1.02453539
64MP0002111_abnormal_tail_morphology1.01266733
65MP0000647_abnormal_sebaceous_gland1.00348441
66MP0000358_abnormal_cell_content/0.99452723
67MP0002160_abnormal_reproductive_system0.98688734
68MP0001119_abnormal_female_reproductive0.97579792
69MP0005408_hypopigmentation0.93888474
70MP0001177_atelectasis0.92197968
71MP0001984_abnormal_olfaction0.91573104
72MP0003186_abnormal_redox_activity0.89863433
73MP0005367_renal/urinary_system_phenotyp0.88514712
74MP0000516_abnormal_urinary_system0.88514712
75MP0009333_abnormal_splenocyte_physiolog0.88082950
76MP0000703_abnormal_thymus_morphology0.87953749
77MP0003755_abnormal_palate_morphology0.87683178
78MP0002090_abnormal_vision0.87106033
79MP0001849_ear_inflammation0.86977658
80MP0001529_abnormal_vocalization0.86934866
81MP0005384_cellular_phenotype0.85486787
82MP0002751_abnormal_autonomic_nervous0.85428932
83MP0000762_abnormal_tongue_morphology0.83843017
84MP0002938_white_spotting0.83282235
85MP0005389_reproductive_system_phenotype0.81468698
86MP0002102_abnormal_ear_morphology0.80487585
87MP0004272_abnormal_basement_membrane0.80179261
88MP0000566_synostosis0.79946778
89MP0001764_abnormal_homeostasis0.79892228
90MP0004215_abnormal_myocardial_fiber0.78915553
91MP0002254_reproductive_system_inflammat0.77836512
92MP0005397_hematopoietic_system_phenotyp0.77738681
93MP0001545_abnormal_hematopoietic_system0.77738681
94MP0006054_spinal_hemorrhage0.77373224
95MP0005395_other_phenotype0.76806170
96MP0000749_muscle_degeneration0.76166563
97MP0005084_abnormal_gallbladder_morpholo0.76036329
98MP0000428_abnormal_craniofacial_morphol0.76013086
99MP0002163_abnormal_gland_morphology0.75980133
100MP0002398_abnormal_bone_marrow0.75369329
101MP0003122_maternal_imprinting0.75330123
102MP0002932_abnormal_joint_morphology0.75015815
103MP0005621_abnormal_cell_physiology0.74867338
104MP0002722_abnormal_immune_system0.74681953
105MP0009672_abnormal_birth_weight0.74160857
106MP0008995_early_reproductive_senescence0.73873980
107MP0005253_abnormal_eye_physiology0.73566412
108MP0001727_abnormal_embryo_implantation0.73411950
109MP0001188_hyperpigmentation0.72717736
110MP0000689_abnormal_spleen_morphology0.72707532
111MP0009703_decreased_birth_body0.72591363
112MP0005501_abnormal_skin_physiology0.71810793
113MP0002177_abnormal_outer_ear0.70106111
114MP0002092_abnormal_eye_morphology0.69046858
115MP0005023_abnormal_wound_healing0.68413350
116MP0003763_abnormal_thymus_physiology0.67991683
117MP0005391_vision/eye_phenotype0.67676411
118MP0010234_abnormal_vibrissa_follicle0.67073943
119MP0009250_abnormal_appendicular_skeleto0.65636591
120MP0001286_abnormal_eye_development0.64940034
121MP0002161_abnormal_fertility/fecundity0.62708263
122MP0005076_abnormal_cell_differentiation0.62648154
123MP0003935_abnormal_craniofacial_develop0.62595125
124MP0005623_abnormal_meninges_morphology0.62305004
125MP0002269_muscular_atrophy0.62134376
126MP0003699_abnormal_female_reproductive0.61322212
127* MP0003221_abnormal_cardiomyocyte_apopto0.61205004
128MP0003115_abnormal_respiratory_system0.60971796
129MP0000477_abnormal_intestine_morphology0.59931605
130MP0002429_abnormal_blood_cell0.59840243
131MP0003942_abnormal_urinary_system0.58627007
132MP0003861_abnormal_nervous_system0.57386485
133MP0002132_abnormal_respiratory_system0.57054325
134MP0008789_abnormal_olfactory_epithelium0.55667576
135MP0003698_abnormal_male_reproductive0.55546404
136MP0006292_abnormal_olfactory_placode0.54753285
137MP0003283_abnormal_digestive_organ0.54382299
138MP0002114_abnormal_axial_skeleton0.53980538
139MP0002282_abnormal_trachea_morphology0.53603937
140MP0000049_abnormal_middle_ear0.52843126
141MP0000432_abnormal_head_morphology0.52283630

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.23468275
2Cerebral hypomyelination (HP:0006808)4.12041272
3Reticulocytopenia (HP:0001896)4.04143074
4Colon cancer (HP:0003003)3.98937689
5Oral leukoplakia (HP:0002745)3.98113206
6Breast hypoplasia (HP:0003187)3.73162607
7Degeneration of anterior horn cells (HP:0002398)3.67669769
8Abnormality of the anterior horn cell (HP:0006802)3.67669769
9Selective tooth agenesis (HP:0001592)3.64285178
10Patellar aplasia (HP:0006443)3.60386154
11Ependymoma (HP:0002888)3.47024530
12Medulloblastoma (HP:0002885)3.39413360
13Aplasia/Hypoplasia of the patella (HP:0006498)3.33119434
14Cortical dysplasia (HP:0002539)3.30864027
15Abnormality of cells of the erythroid lineage (HP:0012130)3.29998892
16Carpal bone hypoplasia (HP:0001498)3.21106004
17Chromsome breakage (HP:0040012)3.15473240
18Abnormality of the labia minora (HP:0012880)3.15090398
19Impulsivity (HP:0100710)3.14127944
20Chromosomal breakage induced by crosslinking agents (HP:0003221)3.12153886
21Abnormal number of erythroid precursors (HP:0012131)3.11278132
22Aplastic anemia (HP:0001915)2.98604889
23Abnormality of methionine metabolism (HP:0010901)2.91836626
24Meckel diverticulum (HP:0002245)2.91616115
25Agnosia (HP:0010524)2.91200066
26Rough bone trabeculation (HP:0100670)2.88936093
27Acute encephalopathy (HP:0006846)2.83110153
28Abnormality of chromosome stability (HP:0003220)2.81298697
29Abnormality of the ileum (HP:0001549)2.78164004
30Acute necrotizing encephalopathy (HP:0006965)2.77946951
31Small intestinal stenosis (HP:0012848)2.74569336
32Duodenal stenosis (HP:0100867)2.74569336
33Microvesicular hepatic steatosis (HP:0001414)2.74351810
34Absent thumb (HP:0009777)2.73879949
35Abnormal number of incisors (HP:0011064)2.73510954
36Abnormality of the preputium (HP:0100587)2.72797968
37Rhabdomyosarcoma (HP:0002859)2.71639496
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.69131869
39Absent radius (HP:0003974)2.66257716
40Premature ovarian failure (HP:0008209)2.66137527
41Macrocytic anemia (HP:0001972)2.64264496
42Abnormal lung lobation (HP:0002101)2.61688308
43Myelodysplasia (HP:0002863)2.61617522
44Premature graying of hair (HP:0002216)2.58990636
45Type I transferrin isoform profile (HP:0003642)2.57600821
46Supernumerary spleens (HP:0009799)2.57000751
47Increased hepatocellular lipid droplets (HP:0006565)2.54889090
48Horseshoe kidney (HP:0000085)2.54883474
49Neoplasm of the pancreas (HP:0002894)2.54780894
50Increased CSF lactate (HP:0002490)2.50897553
51Reduced antithrombin III activity (HP:0001976)2.49075838
52Absent forearm bone (HP:0003953)2.48091112
53Aplasia involving forearm bones (HP:0009822)2.48091112
54Increased serum pyruvate (HP:0003542)2.43485395
55Abnormality of glycolysis (HP:0004366)2.43485395
56Microretrognathia (HP:0000308)2.42814313
57Abnormality of the duodenum (HP:0002246)2.41582879
58Postnatal microcephaly (HP:0005484)2.40687749
59Progressive macrocephaly (HP:0004481)2.40330463
60Cellular immunodeficiency (HP:0005374)2.40276733
61CNS hypomyelination (HP:0003429)2.38878794
62Trismus (HP:0000211)2.38850491
63Bone marrow hypocellularity (HP:0005528)2.36008047
64Abnormal mitochondria in muscle tissue (HP:0008316)2.35492313
65Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.34762838
66Pallor (HP:0000980)2.34097308
6711 pairs of ribs (HP:0000878)2.32228562
68Sloping forehead (HP:0000340)2.30830638
69Increased serum lactate (HP:0002151)2.30460392
70Thrombocytosis (HP:0001894)2.28917000
71Lipid accumulation in hepatocytes (HP:0006561)2.26846150
72Mitochondrial inheritance (HP:0001427)2.26603040
73Abnormality of serum amino acid levels (HP:0003112)2.26570063
74Proximal placement of thumb (HP:0009623)2.24803137
75Volvulus (HP:0002580)2.24259568
76Astrocytoma (HP:0009592)2.24162457
77Abnormality of the astrocytes (HP:0100707)2.24162457
78Cerebral edema (HP:0002181)2.22865910
79Cleft eyelid (HP:0000625)2.20767434
80Abnormality of aspartate family amino acid metabolism (HP:0010899)2.19637819
81Atrophy/Degeneration involving motor neurons (HP:0007373)2.19580523
82Methylmalonic acidemia (HP:0002912)2.19432642
83Tracheoesophageal fistula (HP:0002575)2.19327034
84Shoulder girdle muscle weakness (HP:0003547)2.18908753
85Secondary amenorrhea (HP:0000869)2.18519574
86Glossoptosis (HP:0000162)2.17920607
87Nephroblastoma (Wilms tumor) (HP:0002667)2.15884736
88Amaurosis fugax (HP:0100576)2.14724428
89Deviation of the thumb (HP:0009603)2.14590011
90Embryonal renal neoplasm (HP:0011794)2.13317701
91Hepatocellular necrosis (HP:0001404)2.13233695
92Ectopic kidney (HP:0000086)2.11451714
93Pancytopenia (HP:0001876)2.09581756
94Multiple enchondromatosis (HP:0005701)2.06833500
95Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.04800597
96Abnormality of alanine metabolism (HP:0010916)2.04800597
97Hyperalaninemia (HP:0003348)2.04800597
98Atresia of the external auditory canal (HP:0000413)2.04364080
99Squamous cell carcinoma (HP:0002860)2.03605653
100Gonadotropin excess (HP:0000837)2.02943387
101Abnormal protein N-linked glycosylation (HP:0012347)2.02574703
102Abnormal protein glycosylation (HP:0012346)2.02574703
103Abnormal glycosylation (HP:0012345)2.02574703
104Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.02574703
105Increased nuchal translucency (HP:0010880)2.02053110
106Bifid tongue (HP:0010297)2.01989986
107Triphalangeal thumb (HP:0001199)2.01766020
108Neoplasm of striated muscle (HP:0009728)2.01542993
109Aplasia/Hypoplasia of the sternum (HP:0006714)2.01284237
110Neoplasm of the colon (HP:0100273)2.01165985
111Optic nerve coloboma (HP:0000588)2.01022091
112Slender long bone (HP:0003100)2.00589068
113Glioma (HP:0009733)1.97555898
114Abnormality of the hip-girdle musculature (HP:0001445)1.94284065
115Abnormality of the musculature of the pelvis (HP:0001469)1.94284065
116Lactic acidosis (HP:0003128)1.93948782
117Hepatic necrosis (HP:0002605)1.93077486
118Abnormal trabecular bone morphology (HP:0100671)1.92983822
119Cutaneous melanoma (HP:0012056)1.92002143
120Stenosis of the external auditory canal (HP:0000402)1.91959734
121Medial flaring of the eyebrow (HP:0010747)1.91784055
122Neoplasm of the adrenal gland (HP:0100631)1.91487779
123Hyperglycinemia (HP:0002154)1.90657088
124Short thumb (HP:0009778)1.88725669
125Abdominal situs inversus (HP:0003363)1.88406764
126Abnormality of abdominal situs (HP:0011620)1.88406764
127Aplasia/hypoplasia of the humerus (HP:0006507)1.88293174
128Facial cleft (HP:0002006)1.88024445
129Ureteral duplication (HP:0000073)1.87030336
130Hypoplasia of the capital femoral epiphysis (HP:0003090)1.86739394
131Abnormality of the umbilical cord (HP:0010881)1.86720147
132Poor head control (HP:0002421)1.85787572
133Megaloblastic anemia (HP:0001889)1.83950559
134Abnormalities of placenta or umbilical cord (HP:0001194)1.83014305
135Abnormality of the fetal cardiovascular system (HP:0010948)1.83002816
136Abnormal umbilical cord blood vessels (HP:0011403)1.83002816
137Single umbilical artery (HP:0001195)1.83002816
138Cafe-au-lait spot (HP:0000957)1.82266801
139High anterior hairline (HP:0009890)1.82151317
140Basal cell carcinoma (HP:0002671)1.81993357
141Congenital primary aphakia (HP:0007707)1.77364363
142Abnormality of the septum pellucidum (HP:0007375)1.76780656
143Abnormality of placental membranes (HP:0011409)1.76540754
144Amniotic constriction ring (HP:0009775)1.76540754
145Nephrogenic diabetes insipidus (HP:0009806)1.75039375
146Abnormality of the carotid arteries (HP:0005344)1.74070549
147Aplasia/Hypoplasia of the sacrum (HP:0008517)1.71816599
148Freckling (HP:0001480)1.70303267
149Sparse eyelashes (HP:0000653)1.69925419
150Aplasia/Hypoplasia involving the musculature (HP:0001460)1.69902979
151Facial hemangioma (HP:0000329)1.69697739
152Spastic diplegia (HP:0001264)1.66417310
153Exercise intolerance (HP:0003546)1.65970888
154Posterior subcapsular cataract (HP:0007787)1.65953013
155Leukodystrophy (HP:0002415)1.65790329
156Entropion (HP:0000621)1.65737714

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.28069941
2WEE14.54152231
3CDC74.17792972
4EIF2AK13.56943480
5TRIM283.18430254
6ACVR1B2.78920627
7NEK12.69851105
8BRSK22.68760950
9TSSK62.61804414
10NEK22.54770194
11SRPK12.45389511
12VRK22.36315157
13TTK2.27419534
14TGFBR12.13459425
15PLK12.12294439
16PASK1.94774950
17EIF2AK31.93609558
18PLK31.86784121
19TESK21.83990848
20DYRK31.80806191
21MKNK11.78755790
22PLK41.76685146
23CCNB11.73247648
24ERBB41.70810272
25VRK11.68460000
26ERBB31.68185792
27ATR1.66423498
28AURKB1.66352620
29BRSK11.65209783
30CDK71.62551618
31NME21.60231696
32TLK11.59808799
33NUAK11.57888721
34TNIK1.53360929
35STK161.52928722
36CHEK21.44255248
37RPS6KB21.42875635
38WNK31.41215078
39CDK121.37639558
40AURKA1.31010696
41CDK81.27134629
42MAP3K81.25088071
43STK101.24414593
44RPS6KA41.21443195
45* CHEK11.14538105
46EEF2K1.13784161
47MAP3K121.09268635
48MAP3K41.06685483
49PLK21.03310957
50PAK41.01150968
51CDK40.99342609
52MELK0.97480476
53SCYL20.94485820
54EPHA20.93231344
55MAP2K70.92950846
56SIK30.92526357
57BRD40.91697345
58MKNK20.85041896
59PDK30.81618760
60PDK40.81618760
61TAF10.81026907
62DYRK20.79498897
63CDK20.77717613
64ATM0.76046890
65BMPR1B0.75919820
66BRAF0.74072511
67STK40.73419159
68CLK10.72128752
69LRRK20.69275782
70PBK0.69212814
71BCKDK0.69169017
72CSNK2A20.65157323
73CSNK2A10.63756564
74PAK10.63545549
75CDK10.63296132
76CSNK1G20.60393123
77MAP4K20.60010876
78BCR0.55803072
79MAP3K100.55388078
80ZAK0.54992275
81STK38L0.54550598
82CASK0.53332020
83NEK90.52945806
84KSR10.50672111
85CSNK1A1L0.49731619
86PIM10.49271393
87CSNK1G30.48704005
88EIF2AK20.48229355
89FLT30.46956075
90ALK0.45983066
91NME10.45530679
92MST1R0.43831269
93TESK10.43087224
94ILK0.42124338
95CDK60.40416861
96PRKCI0.40392907
97CDK190.38793573
98LIMK10.38667163
99MINK10.36793972
100RPS6KA50.36410678
101AKT20.35508697
102PNCK0.33604417
103FGFR10.31173437
104CSNK1E0.30475618
105KDR0.29164441
106CSNK1G10.29084191
107NEK60.29001244
108MST40.28546514
109MET0.28304224
110CDK30.27903629
111STK390.27809912
112BTK0.26726651
113PRKCE0.25937985
114DAPK10.25619806
115PDK20.23758563
116PIM20.23656560
117MARK30.23240003
118GRK10.22875091
119PRKDC0.21426792
120CDK150.21343272
121STK30.20167258
122MAP3K30.19308732
123CDK180.18211799
124ABL20.17362296
125FGFR20.17343043
126MAPKAPK20.17148008
127CDK11A0.14790279
128CDK140.14681475
129LATS20.14550516
130MTOR0.14238202
131MAPK140.13703952

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.99651526
2Mismatch repair_Homo sapiens_hsa034304.26308571
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.76011019
4Proteasome_Homo sapiens_hsa030503.60331664
5RNA polymerase_Homo sapiens_hsa030203.44240278
6* Spliceosome_Homo sapiens_hsa030403.41031377
7RNA transport_Homo sapiens_hsa030133.29094860
8Ribosome_Homo sapiens_hsa030103.20290383
9Base excision repair_Homo sapiens_hsa034102.98941183
10Cell cycle_Homo sapiens_hsa041102.95969871
11Nucleotide excision repair_Homo sapiens_hsa034202.92242722
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.89893160
13Homologous recombination_Homo sapiens_hsa034402.76580848
14One carbon pool by folate_Homo sapiens_hsa006702.73292330
15Pyrimidine metabolism_Homo sapiens_hsa002402.44154968
16Basal transcription factors_Homo sapiens_hsa030222.11617519
17Fanconi anemia pathway_Homo sapiens_hsa034601.99700862
18Non-homologous end-joining_Homo sapiens_hsa034501.98178970
19RNA degradation_Homo sapiens_hsa030181.89380414
20mRNA surveillance pathway_Homo sapiens_hsa030151.87000213
21Propanoate metabolism_Homo sapiens_hsa006401.83728665
22Fatty acid elongation_Homo sapiens_hsa000621.65215335
23p53 signaling pathway_Homo sapiens_hsa041151.55306130
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49810214
25Purine metabolism_Homo sapiens_hsa002301.37818327
26Steroid biosynthesis_Homo sapiens_hsa001001.34725066
27Systemic lupus erythematosus_Homo sapiens_hsa053221.33553830
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32056114
29Epstein-Barr virus infection_Homo sapiens_hsa051691.23857246
30Vitamin B6 metabolism_Homo sapiens_hsa007501.19467025
31Folate biosynthesis_Homo sapiens_hsa007901.16328717
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11165273
33Biosynthesis of amino acids_Homo sapiens_hsa012301.09750760
34Oocyte meiosis_Homo sapiens_hsa041141.09371945
35Sulfur relay system_Homo sapiens_hsa041220.96522259
36Viral carcinogenesis_Homo sapiens_hsa052030.95679723
37Cysteine and methionine metabolism_Homo sapiens_hsa002700.92620295
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92221047
39Selenocompound metabolism_Homo sapiens_hsa004500.89702018
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87708682
41Pentose phosphate pathway_Homo sapiens_hsa000300.86295581
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84726140
43Protein export_Homo sapiens_hsa030600.84571000
44Alzheimers disease_Homo sapiens_hsa050100.83554501
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77411333
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76944121
47Antigen processing and presentation_Homo sapiens_hsa046120.74656451
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.74178697
49Sulfur metabolism_Homo sapiens_hsa009200.73838684
50Fatty acid metabolism_Homo sapiens_hsa012120.71865671
51Herpes simplex infection_Homo sapiens_hsa051680.71223407
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69809057
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67442831
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.66599493
55HTLV-I infection_Homo sapiens_hsa051660.65743606
56Carbon metabolism_Homo sapiens_hsa012000.63693299
57Butanoate metabolism_Homo sapiens_hsa006500.63194284
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60595695
59Peroxisome_Homo sapiens_hsa041460.60219900
60Thyroid cancer_Homo sapiens_hsa052160.58484984
61Alcoholism_Homo sapiens_hsa050340.57271357
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56669333
63MicroRNAs in cancer_Homo sapiens_hsa052060.56516585
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55044189
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54871082
66Hippo signaling pathway_Homo sapiens_hsa043900.54797999
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54284861
68Basal cell carcinoma_Homo sapiens_hsa052170.52620187
69Legionellosis_Homo sapiens_hsa051340.52536544
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51078002
71Huntingtons disease_Homo sapiens_hsa050160.50233505
72Fatty acid degradation_Homo sapiens_hsa000710.47388763
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46225103
74Fructose and mannose metabolism_Homo sapiens_hsa000510.45100213
75Colorectal cancer_Homo sapiens_hsa052100.43915291
76beta-Alanine metabolism_Homo sapiens_hsa004100.43730765
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43001523
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41270410
79Notch signaling pathway_Homo sapiens_hsa043300.41111051
80TGF-beta signaling pathway_Homo sapiens_hsa043500.40481732
81Small cell lung cancer_Homo sapiens_hsa052220.40259421
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38813312
83Glutathione metabolism_Homo sapiens_hsa004800.38545566
84N-Glycan biosynthesis_Homo sapiens_hsa005100.37761466
85Shigellosis_Homo sapiens_hsa051310.34882863
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33075792
87Parkinsons disease_Homo sapiens_hsa050120.32991910
88Hedgehog signaling pathway_Homo sapiens_hsa043400.31920879
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31052535
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27601409
91Apoptosis_Homo sapiens_hsa042100.27054115
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26973464
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.25597449
94Metabolic pathways_Homo sapiens_hsa011000.23941080
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23418829
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.23053206
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.21840481
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.19966646
99Pathways in cancer_Homo sapiens_hsa052000.19942004
100Bladder cancer_Homo sapiens_hsa052190.19656623
101Vibrio cholerae infection_Homo sapiens_hsa051100.19174180
102Adherens junction_Homo sapiens_hsa045200.17601079
103HIF-1 signaling pathway_Homo sapiens_hsa040660.16969074
104Pyruvate metabolism_Homo sapiens_hsa006200.15885042
105Hepatitis B_Homo sapiens_hsa051610.15642650
106Caffeine metabolism_Homo sapiens_hsa002320.14969773
107Retinol metabolism_Homo sapiens_hsa008300.14539470
108Galactose metabolism_Homo sapiens_hsa000520.12432959
109Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.10387417
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.10062723
111Primary immunodeficiency_Homo sapiens_hsa053400.09956697
112Collecting duct acid secretion_Homo sapiens_hsa049660.09858518
113Chronic myeloid leukemia_Homo sapiens_hsa052200.08309971
114Wnt signaling pathway_Homo sapiens_hsa043100.06992494
115mTOR signaling pathway_Homo sapiens_hsa041500.06432592
116Tyrosine metabolism_Homo sapiens_hsa003500.05457122
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.05317305
118Cardiac muscle contraction_Homo sapiens_hsa042600.05144856
119Influenza A_Homo sapiens_hsa051640.05020119
120Arginine and proline metabolism_Homo sapiens_hsa003300.04583832
121Oxidative phosphorylation_Homo sapiens_hsa001900.03946375
122Measles_Homo sapiens_hsa051620.01458131
123Pancreatic cancer_Homo sapiens_hsa052120.01288666
124Regulation of autophagy_Homo sapiens_hsa041400.01085223
125Renin-angiotensin system_Homo sapiens_hsa046140.00153930
126Tight junction_Homo sapiens_hsa04530-0.0164631
127Non-small cell lung cancer_Homo sapiens_hsa05223-0.0152397
128PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0110476

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