PLS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. The protein encoded by this gene is a third distinct plastin isoform, which is specifically expressed at high levels in the small intestine. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. A pseudogene of this gene is found on chromosome 11. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal cholesterol absorption (GO:0030299)9.83337559
2angiotensin maturation (GO:0002003)9.23748200
3regulation of guanylate cyclase activity (GO:0031282)6.80007442
4cellular glucuronidation (GO:0052695)6.43140859
5uronic acid metabolic process (GO:0006063)6.23743896
6glucuronate metabolic process (GO:0019585)6.23743896
7NADH metabolic process (GO:0006734)6.12187550
8adhesion of symbiont to host cell (GO:0044650)5.97700459
9virion attachment to host cell (GO:0019062)5.97700459
10axon ensheathment in central nervous system (GO:0032291)5.80997111
11central nervous system myelination (GO:0022010)5.80997111
12regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.77340280
13actin filament depolymerization (GO:0030042)5.74426634
14fat-soluble vitamin biosynthetic process (GO:0042362)5.36445199
15vitamin A metabolic process (GO:0006776)5.34892110
16positive regulation of guanylate cyclase activity (GO:0031284)5.22429945
17regulation of bile acid biosynthetic process (GO:0070857)5.12188094
18drug catabolic process (GO:0042737)5.05858450
19purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.96230261
203-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.96230261
21digestive system process (GO:0022600)4.82860153
22sulfate transmembrane transport (GO:1902358)4.78301419
23bundle of His cell to Purkinje myocyte communication (GO:0086069)4.73878851
24flavonoid metabolic process (GO:0009812)4.61718887
25urea cycle (GO:0000050)4.59193926
26regulation of systemic arterial blood pressure (GO:0003073)4.58354203
27adhesion of symbiont to host (GO:0044406)4.57071973
28regulation of cellular extravasation (GO:0002691)4.51499768
29urea metabolic process (GO:0019627)4.44309501
30fructose metabolic process (GO:0006000)4.41523038
31response to hepatocyte growth factor (GO:0035728)4.28941904
32cellular response to hepatocyte growth factor stimulus (GO:0035729)4.28941904
33digestion (GO:0007586)4.28437593
34regulation of lipoprotein metabolic process (GO:0050746)4.13845948
35regulation of cholesterol esterification (GO:0010872)4.08616912
36regulation of cGMP biosynthetic process (GO:0030826)4.07119882
37renal system process involved in regulation of blood volume (GO:0001977)4.07076680
38UDP-N-acetylglucosamine metabolic process (GO:0006047)4.05962433
39sperm capacitation (GO:0048240)4.03865741
40positive regulation of lipoprotein lipase activity (GO:0051006)3.99384337
41positive regulation of triglyceride lipase activity (GO:0061365)3.99384337
42receptor guanylyl cyclase signaling pathway (GO:0007168)3.98761239
43positive regulation of glycoprotein biosynthetic process (GO:0010560)3.98387215
44nitrogen cycle metabolic process (GO:0071941)3.96311629
45antibacterial humoral response (GO:0019731)3.96168648
46vitamin transmembrane transport (GO:0035461)3.95253014
47maintenance of gastrointestinal epithelium (GO:0030277)3.94906426
48peptide hormone processing (GO:0016486)3.94168622
49very-low-density lipoprotein particle assembly (GO:0034379)3.91621970
50sulfate transport (GO:0008272)3.91499851
51regulation of vitamin metabolic process (GO:0030656)3.86777579
52phospholipid efflux (GO:0033700)3.86624586
53cholesterol efflux (GO:0033344)3.85099330
54protein-lipid complex assembly (GO:0065005)3.84988792
55glycolipid catabolic process (GO:0019377)3.81302557
56lipoprotein metabolic process (GO:0042157)3.77623643
57bile acid metabolic process (GO:0008206)3.76941979
58antimicrobial humoral response (GO:0019730)3.76506784
59transepithelial transport (GO:0070633)3.74856977
60plasma lipoprotein particle assembly (GO:0034377)3.73445483
61modified amino acid transport (GO:0072337)3.70267596
62glycosphingolipid catabolic process (GO:0046479)3.70226670
63sulfur compound transport (GO:0072348)3.69606794
64hormone catabolic process (GO:0042447)3.68542239
65ethanol oxidation (GO:0006069)3.67752839
66homocysteine metabolic process (GO:0050667)3.65439010
67positive regulation of glycoprotein metabolic process (GO:1903020)3.64208752
68intestinal epithelial cell development (GO:0060576)3.64014594
69polyol transport (GO:0015791)3.62360308
70calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.62263423
71cholesterol homeostasis (GO:0042632)3.60196099
72sterol homeostasis (GO:0055092)3.56481928
73bicarbonate transport (GO:0015701)3.54945059
74arginine metabolic process (GO:0006525)3.54149280
75positive regulation of pseudopodium assembly (GO:0031274)3.53878852
76triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.53547644
77positive regulation of respiratory burst (GO:0060267)3.52622087
78glutamine family amino acid biosynthetic process (GO:0009084)3.51559052
79sphingomyelin metabolic process (GO:0006684)3.48926028
80regulation of triglyceride catabolic process (GO:0010896)3.47760622
81O-glycan processing (GO:0016266)3.47039929
82lipoprotein transport (GO:0042953)3.46120159
83oligosaccharide catabolic process (GO:0009313)3.44231719
84thyroid hormone metabolic process (GO:0042403)3.43598557
85citrulline biosynthetic process (GO:0019240)3.42416285
86cobalamin metabolic process (GO:0009235)3.35424785
87sphingolipid catabolic process (GO:0030149)3.35290587
88fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.34935440
89bile acid and bile salt transport (GO:0015721)3.34894757
90alkaloid metabolic process (GO:0009820)3.34168296
91auditory receptor cell differentiation (GO:0042491)3.33610773
92drinking behavior (GO:0042756)3.31982959
93myelin maintenance (GO:0043217)3.31652544
94cholesterol biosynthetic process (GO:0006695)3.30678976
95sulfation (GO:0051923)3.29632887
96vitamin transport (GO:0051180)3.29398901
97negative regulation of digestive system process (GO:0060457)3.29156834
98cholesterol transport (GO:0030301)3.28254317
99sterol transport (GO:0015918)3.28254317
100desmosome organization (GO:0002934)3.28081923
101glycoside metabolic process (GO:0016137)3.28024957
102regulation of cGMP metabolic process (GO:0030823)3.27777870
103oligosaccharide biosynthetic process (GO:0009312)3.27709650
104regulation of protein glycosylation (GO:0060049)3.24801704
105membrane lipid catabolic process (GO:0046466)3.20055857
106mRNA modification (GO:0016556)3.18570429
107midgut development (GO:0007494)3.18061818
108nucleoside diphosphate biosynthetic process (GO:0009133)3.17493043
109phenylpropanoid metabolic process (GO:0009698)3.16790576
110peptide catabolic process (GO:0043171)3.15248796
111vitamin biosynthetic process (GO:0009110)3.14105130
112fat-soluble vitamin metabolic process (GO:0006775)3.13825807
113regulation of pseudopodium assembly (GO:0031272)3.13013088
114glycosylceramide metabolic process (GO:0006677)3.12670241
115glucose 6-phosphate metabolic process (GO:0051156)3.11389781
116glutathione derivative metabolic process (GO:1901685)3.11051387
117glutathione derivative biosynthetic process (GO:1901687)3.11051387
118ceramide catabolic process (GO:0046514)3.05339797
119ethanol metabolic process (GO:0006067)3.04336215
120negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.03924765
121diacylglycerol metabolic process (GO:0046339)2.98996514
122negative regulation of sterol transport (GO:0032372)2.95570249
123negative regulation of cholesterol transport (GO:0032375)2.95570249
124drug transmembrane transport (GO:0006855)2.92780644
125regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.89689231
126tight junction assembly (GO:0070830)2.88632287
127sterol biosynthetic process (GO:0016126)2.88149597
128drug transport (GO:0015893)2.84232878
129reverse cholesterol transport (GO:0043691)2.80964508
130regulation of digestive system process (GO:0044058)2.80399222
131exogenous drug catabolic process (GO:0042738)2.80328888
132negative regulation of keratinocyte proliferation (GO:0010839)2.79312190
133phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.79164915
134drug metabolic process (GO:0017144)2.77824484
135glutathione biosynthetic process (GO:0006750)2.74032951
136axon ensheathment (GO:0008366)2.73051226
137ensheathment of neurons (GO:0007272)2.73051226
138regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.72693349
139endocrine process (GO:0050886)2.72693349
140regulation of systemic arterial blood pressure by hormone (GO:0001990)2.72693349
141glycerophospholipid catabolic process (GO:0046475)2.71354387
142regulation of cholesterol homeostasis (GO:2000188)2.71285019
143response to phenylpropanoid (GO:0080184)2.69062439
144protein kinase C signaling (GO:0070528)2.66918970
145epithelial structure maintenance (GO:0010669)2.66625986
146peptide biosynthetic process (GO:0043043)2.66375683
147mucosal immune response (GO:0002385)2.65109075
148glycerol metabolic process (GO:0006071)2.64988297
149fatty acid elongation (GO:0030497)2.64819055
150epoxygenase P450 pathway (GO:0019373)2.64336289
151branching involved in labyrinthine layer morphogenesis (GO:0060670)2.63649928
152transcytosis (GO:0045056)2.62991368
153signal peptide processing (GO:0006465)2.62967444
154intestinal absorption (GO:0050892)10.2636735

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.53537880
2CDX2_20551321_ChIP-Seq_CACO-2_Human3.89030721
3* SOX2_27498859_Chip-Seq_STOMACH_Mouse3.29360244
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.73364938
5* IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.67684569
6GATA4_25053715_ChIP-Seq_YYC3_Human2.54108543
7CDX2_19796622_ChIP-Seq_MESCs_Mouse2.48358902
8SOX2_20726797_ChIP-Seq_SW620_Human2.35431964
9VDR_22108803_ChIP-Seq_LS180_Human2.18839298
10GATA6_25053715_ChIP-Seq_YYC3_Human2.11073991
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.06010947
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.00385661
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.99756861
14PPAR_26484153_Chip-Seq_NCI-H1993_Human1.91807702
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.87627395
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.84095611
17ESR2_21235772_ChIP-Seq_MCF-7_Human1.79615512
18TRIM28_21343339_ChIP-Seq_HEK293_Human1.78238732
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77575803
20FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.74450536
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.73420400
22ZNF217_24962896_ChIP-Seq_MCF-7_Human1.71562808
23ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.66699337
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.65819159
25KLF5_25053715_ChIP-Seq_YYC3_Human1.62043369
26PPARA_22158963_ChIP-Seq_LIVER_Mouse1.60989088
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.59841358
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.57567345
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.56608318
30FOXO3_23340844_ChIP-Seq_DLD1_Human1.56204855
31RXR_22158963_ChIP-Seq_LIVER_Mouse1.56054211
32CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.55511294
33NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.55279554
34CLOCK_20551151_ChIP-Seq_293T_Human1.51519683
35GATA1_26923725_Chip-Seq_HPCs_Mouse1.49001709
36TCF4_18268006_ChIP-ChIP_LS174T_Human1.47838573
37EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.39911834
38FOXA2_19822575_ChIP-Seq_HepG2_Human1.38699278
39ESR1_20079471_ChIP-ChIP_T-47D_Human1.38502228
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.38055706
41* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30790967
42FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.30532341
43AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.30112861
44GATA1_22025678_ChIP-Seq_K562_Human1.29352754
45FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.26976954
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.25785211
47BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25609529
48RUNX1_27514584_Chip-Seq_MCF-7_Human1.23990352
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23651280
50SALL4_18804426_ChIP-ChIP_XEN_Mouse1.22561653
51EGR1_23403033_ChIP-Seq_LIVER_Mouse1.22176606
52DROSHA_22980978_ChIP-Seq_HELA_Human1.21784856
53FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19393158
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15821649
55* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14645295
56CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13575537
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11594664
58BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.11585097
59CDX2_22108803_ChIP-Seq_LS180_Human1.11464859
60FOXA1_25552417_ChIP-Seq_VCAP_Human1.10347109
61TCF3_18692474_ChIP-Seq_MEFs_Mouse1.10163924
62CEBPB_22108803_ChIP-Seq_LS180_Human1.09314660
63HNF4A_19822575_ChIP-Seq_HepG2_Human1.08749114
64NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.08379075
65ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07667408
66STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06936718
67* TP63_23658742_ChIP-Seq_EP156T_Human1.06263627
68* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04954803
69SMAD3_21741376_ChIP-Seq_HESCs_Human1.04815548
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04685244
71TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.04209602
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.03825584
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02991450
74* GATA2_19941826_ChIP-Seq_K562_Human1.02431741
75AR_21909140_ChIP-Seq_LNCAP_Human1.01050927
76SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00232400
77PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99255589
78* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98568256
79PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97276741
80AHR_22903824_ChIP-Seq_MCF-7_Human0.97077480
81ZNF263_19887448_ChIP-Seq_K562_Human0.96986901
82MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96859536
83BCAT_22108803_ChIP-Seq_LS180_Human0.94936198
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.94862418
85NRF2_20460467_ChIP-Seq_MEFs_Mouse0.94862418
86SMAD3_21741376_ChIP-Seq_EPCs_Human0.94525374
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94253200
88JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93784883
89SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.93758676
90SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.93758676
91CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93045718
92HNFA_21074721_ChIP-Seq_CACO-2_Human0.92894458
93AR_20517297_ChIP-Seq_VCAP_Human0.91853669
94TAL1_26923725_Chip-Seq_HPCs_Mouse0.91533582
95FOXA1_21572438_ChIP-Seq_LNCaP_Human0.90024026
96CBP_21632823_ChIP-Seq_H3396_Human0.89462486
97KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.89288153
98* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.88779589
99CJUN_26792858_Chip-Seq_BT549_Human0.88064652
100FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.88015556
101TCF4_22108803_ChIP-Seq_LS180_Human0.87911722
102P63_26484246_Chip-Seq_KERATINOCYTES_Human0.87527948
103PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.86664124
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86273524
105WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86144371
106PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85275619
107ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85084640
108EP300_21415370_ChIP-Seq_HL-1_Mouse0.83897156
109FOXA1_25329375_ChIP-Seq_VCAP_Human0.83456881
110FOXA1_27270436_Chip-Seq_PROSTATE_Human0.83456881
111ARNT_22903824_ChIP-Seq_MCF-7_Human0.83450800
112SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.83271613
113* NANOG_20526341_ChIP-Seq_ESCs_Human0.83106003
114SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82705838
115GATA3_24758297_ChIP-Seq_MCF-7_Human0.82346712
116KAP1_22055183_ChIP-Seq_ESCs_Mouse0.82029629
117SOX9_24532713_ChIP-Seq_HFSC_Mouse0.80269894
118RXR_22108803_ChIP-Seq_LS180_Human0.79955916
119STAT1_17558387_ChIP-Seq_HELA_Human0.79014147
120ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.78955877
121RBPJ_21746931_ChIP-Seq_IB4_Human0.78751724
122* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.78619901
123TP53_16413492_ChIP-PET_HCT116_Human0.78529508
124GATA2_21666600_ChIP-Seq_HMVEC_Human0.77834590
125GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.77141779
126EGR1_19032775_ChIP-ChIP_M12_Human0.77012011
127KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.76710923
128EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.75901389
129CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75715356
130SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.75682781
131RACK7_27058665_Chip-Seq_MCF-7_Human0.75551734
132* STAT3_23295773_ChIP-Seq_U87_Human0.75520184
133PRDM14_20953172_ChIP-Seq_ESCs_Human0.74825384
134SUZ12_27294783_Chip-Seq_NPCs_Mouse0.74622345
135IRF8_22096565_ChIP-ChIP_GC-B_Human0.73552343
136CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.73414755

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.31757773
2MP0001666_abnormal_nutrient_absorption5.68666115
3MP0004264_abnormal_extraembryonic_tissu3.92910669
4MP0010234_abnormal_vibrissa_follicle3.77382494
5MP0000462_abnormal_digestive_system3.52829552
6MP0009840_abnormal_foam_cell3.42108995
7MP0004043_abnormal_pH_regulation3.31627826
8MP0008875_abnormal_xenobiotic_pharmacok3.26029525
9MP0005085_abnormal_gallbladder_physiolo3.06332650
10MP0003183_abnormal_peptide_metabolism3.04612911
11MP0002139_abnormal_hepatobiliary_system2.88260230
12MP0005377_hearing/vestibular/ear_phenot2.65409036
13MP0003878_abnormal_ear_physiology2.65409036
14MP0003252_abnormal_bile_duct2.57155228
15MP0009379_abnormal_foot_pigmentation2.55024604
16MP0003866_abnormal_defecation2.30295895
17MP0002822_catalepsy2.26177188
18MP0003950_abnormal_plasma_membrane2.23640918
19MP0004147_increased_porphyrin_level2.21459456
20MP0000537_abnormal_urethra_morphology2.13061443
21MP0001664_abnormal_digestion2.08298541
22MP0004270_analgesia1.98176963
23MP0010678_abnormal_skin_adnexa1.95403605
24MP0005381_digestive/alimentary_phenotyp1.91803096
25MP0004019_abnormal_vitamin_homeostasis1.87232415
26MP0010329_abnormal_lipoprotein_level1.84980017
27MP0005365_abnormal_bile_salt1.81557590
28MP0003806_abnormal_nucleotide_metabolis1.78733867
29MP0005084_abnormal_gallbladder_morpholo1.74575674
30MP0001663_abnormal_digestive_system1.70555185
31MP0001873_stomach_inflammation1.67056147
32MP0001485_abnormal_pinna_reflex1.60739833
33MP0001764_abnormal_homeostasis1.58660429
34MP0000538_abnormal_urinary_bladder1.49249018
35MP0000920_abnormal_myelination1.45889670
36MP0000566_synostosis1.40170679
37MP0001188_hyperpigmentation1.39514471
38MP0002796_impaired_skin_barrier1.37064764
39MP0000477_abnormal_intestine_morphology1.31949440
40MP0004885_abnormal_endolymph1.30353430
41MP0002138_abnormal_hepatobiliary_system1.28143323
42MP0005166_decreased_susceptibility_to1.25673143
43MP0010155_abnormal_intestine_physiology1.22520845
44MP0008004_abnormal_stomach_pH1.20358476
45MP0005332_abnormal_amino_acid1.20292374
46MP0009643_abnormal_urine_homeostasis1.20140196
47MP0003329_amyloid_beta_deposits1.19056218
48MP0005451_abnormal_body_composition1.15482134
49MP0003718_maternal_effect1.14834795
50MP0003191_abnormal_cellular_cholesterol1.14011451
51MP0000383_abnormal_hair_follicle1.13299436
52MP0000467_abnormal_esophagus_morphology1.12435094
53MP0001849_ear_inflammation1.11903675
54MP0001756_abnormal_urination1.07600110
55MP0001765_abnormal_ion_homeostasis1.06339686
56MP0005448_abnormal_energy_balance1.04375533
57MP0003300_gastrointestinal_ulcer1.02656226
58MP0003693_abnormal_embryo_hatching1.02540511
59MP0003453_abnormal_keratinocyte_physiol0.99778992
60MP0005670_abnormal_white_adipose0.98012280
61MP0002118_abnormal_lipid_homeostasis0.97608193
62MP0004742_abnormal_vestibular_system0.97395026
63MP0000579_abnormal_nail_morphology0.95987093
64MP0005408_hypopigmentation0.93966222
65MP0000470_abnormal_stomach_morphology0.92803732
66MP0002098_abnormal_vibrissa_morphology0.91770645
67MP0005319_abnormal_enzyme/_coenzyme0.91204699
68MP0006054_spinal_hemorrhage0.90668554
69MP0003879_abnormal_hair_cell0.90525081
70MP0001501_abnormal_sleep_pattern0.89020749
71MP0002876_abnormal_thyroid_physiology0.88936353
72MP0005167_abnormal_blood-brain_barrier0.87303545
73MP0008872_abnormal_physiological_respon0.85743914
74MP0001346_abnormal_lacrimal_gland0.84407510
75MP0005636_abnormal_mineral_homeostasis0.83195569
76MP0000678_abnormal_parathyroid_gland0.83042930
77MP0001881_abnormal_mammary_gland0.82305882
78MP0000604_amyloidosis0.81248902
79MP0005395_other_phenotype0.80151970
80MP0000490_abnormal_crypts_of0.78938990
81MP0005501_abnormal_skin_physiology0.78114361
82MP0009384_cardiac_valve_regurgitation0.75264008
83MP0004782_abnormal_surfactant_physiolog0.75251220
84MP0003690_abnormal_glial_cell0.74841239
85MP0005310_abnormal_salivary_gland0.73462320
86MP0002166_altered_tumor_susceptibility0.73244262
87MP0005584_abnormal_enzyme/coenzyme_acti0.73230653
88MP0002254_reproductive_system_inflammat0.72968318
89MP0000465_gastrointestinal_hemorrhage0.71587587
90MP0000230_abnormal_systemic_arterial0.71118380
91MP0004957_abnormal_blastocyst_morpholog0.70366509
92MP0001963_abnormal_hearing_physiology0.70108031
93MP0009697_abnormal_copulation0.67470789
94MP0004858_abnormal_nervous_system0.66267895
95MP0009780_abnormal_chondrocyte_physiolo0.65601900
96MP0002971_abnormal_brown_adipose0.65341739
97MP0010307_abnormal_tumor_latency0.64767747
98MP0005410_abnormal_fertilization0.64495336
99MP0009642_abnormal_blood_homeostasis0.64285943
100MP0005535_abnormal_body_temperature0.63916108
101MP0002229_neurodegeneration0.63506326
102MP0003953_abnormal_hormone_level0.63453004
103MP0003868_abnormal_feces_composition0.63120277
104MP0003283_abnormal_digestive_organ0.61611069
105MP0000613_abnormal_salivary_gland0.60051714
106MP0000609_abnormal_liver_physiology0.59356904
107MP0005409_darkened_coat_color0.58523306
108MP0002006_tumorigenesis0.58442755
109MP0002078_abnormal_glucose_homeostasis0.58294607
110MP0002396_abnormal_hematopoietic_system0.57699617
111MP0003941_abnormal_skin_development0.57547661
112MP0002136_abnormal_kidney_physiology0.55359690
113MP0003315_abnormal_perineum_morphology0.54528970
114MP0002009_preneoplasia0.54390057
115MP0002896_abnormal_bone_mineralization0.53561405
116MP0002277_abnormal_respiratory_mucosa0.53146597
117MP0000762_abnormal_tongue_morphology0.52977414
118MP0001845_abnormal_inflammatory_respons0.52327695
119MP0009765_abnormal_xenobiotic_induced0.52270737
120MP0003938_abnormal_ear_development0.51282414
121MP0000427_abnormal_hair_cycle0.50995206
122MP0009115_abnormal_fat_cell0.50936851
123MP0001216_abnormal_epidermal_layer0.50667115
124MP0001486_abnormal_startle_reflex0.49565008
125MP0000377_abnormal_hair_follicle0.49258002
126MP0000627_abnormal_mammary_gland0.48735274
127MP0000516_abnormal_urinary_system0.47822591
128MP0005367_renal/urinary_system_phenotyp0.47822591
129MP0005266_abnormal_metabolism0.47461172
130MP0010352_gastrointestinal_tract_polyps0.47448462
131MP0003937_abnormal_limbs/digits/tail_de0.47058181
132MP0008469_abnormal_protein_level0.46432127
133MP0003195_calcinosis0.46423397
134MP0002089_abnormal_postnatal_growth/wei0.45953018
135MP0005165_increased_susceptibility_to0.44922158
136MP0005666_abnormal_adipose_tissue0.43882554

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)7.81678781
2Abnormality of glutamine family amino acid metabolism (HP:0010902)6.09652900
3Acanthocytosis (HP:0001927)5.61256736
4Malnutrition (HP:0004395)5.38066979
5Hydroxyprolinuria (HP:0003080)5.12645024
6Abnormality of proline metabolism (HP:0010907)5.12645024
7Hypobetalipoproteinemia (HP:0003563)5.03120173
8Conjugated hyperbilirubinemia (HP:0002908)4.79249657
9Right ventricular cardiomyopathy (HP:0011663)4.76106031
10Decreased circulating renin level (HP:0003351)4.30778685
11Fat malabsorption (HP:0002630)4.21686549
12Chronic diarrhea (HP:0002028)3.58952268
13Abnormality of the vitamin B12 metabolism (HP:0004341)3.56325059
14Metabolic alkalosis (HP:0200114)3.53397621
15Widely patent fontanelles and sutures (HP:0004492)3.49296297
16Proximal tubulopathy (HP:0000114)3.48563339
17Steatorrhea (HP:0002570)3.41645238
18Abnormality of vitamin B metabolism (HP:0004340)3.36532377
19Abdominal distention (HP:0003270)3.29959512
20Cupped ribs (HP:0000887)3.27554224
21Pigmentary retinal degeneration (HP:0001146)3.26062163
22Degeneration of the lateral corticospinal tracts (HP:0002314)3.19426836
23Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.19426836
24Dehydration (HP:0001944)3.10193742
25Intrahepatic cholestasis (HP:0001406)3.09230648
26Hyperactive renin-angiotensin system (HP:0000841)3.01859359
27Confusion (HP:0001289)3.01722856
28Abnormality of vitamin metabolism (HP:0100508)2.99817321
29Nausea (HP:0002018)2.99809490
30Autoimmune thrombocytopenia (HP:0001973)2.98006284
31Facial shape deformation (HP:0011334)2.94557997
32Potter facies (HP:0002009)2.94557997
33Hyperammonemia (HP:0001987)2.93008302
34Poikilocytosis (HP:0004447)2.92709778
35Congenital sensorineural hearing impairment (HP:0008527)2.91375573
36Flat acetabular roof (HP:0003180)2.78250405
37Abnormality of chloride homeostasis (HP:0011422)2.76236849
38Hypolipoproteinemia (HP:0010981)2.75685295
39Abnormality of aspartate family amino acid metabolism (HP:0010899)2.74263530
40Systemic lupus erythematosus (HP:0002725)2.74263130
41Neurofibrillary tangles (HP:0002185)2.70661697
42Autoimmune hemolytic anemia (HP:0001890)2.69651115
43Posterior subcapsular cataract (HP:0007787)2.68213145
44Glycosuria (HP:0003076)2.67849280
45Abnormality of urine glucose concentration (HP:0011016)2.67849280
46Hyperuricemia (HP:0002149)2.64829433
47Increased purine levels (HP:0004368)2.64829433
48Wide cranial sutures (HP:0010537)2.60768295
49Hyperphosphatemia (HP:0002905)2.59889501
50Hyperglycinuria (HP:0003108)2.59121604
51Biliary tract neoplasm (HP:0100574)2.53326201
52Villous atrophy (HP:0011473)2.52558537
53Abnormality of small intestinal villus morphology (HP:0011472)2.52558537
54Hypotension (HP:0002615)2.52043944
55Xanthomatosis (HP:0000991)2.50399559
56Thin bony cortex (HP:0002753)2.49227025
57Gout (HP:0001997)2.47887077
58Abnormality of purine metabolism (HP:0004352)2.46475932
59Segmental peripheral demyelination/remyelination (HP:0003481)2.46022579
60Abnormality of the corticospinal tract (HP:0002492)2.41771418
61Hypophosphatemia (HP:0002148)2.41277215
62Gastrointestinal dysmotility (HP:0002579)2.33028640
63Metabolic acidosis (HP:0001942)2.32236028
64Esophageal atresia (HP:0002032)2.31162835
65Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.28776163
66Vascular calcification (HP:0004934)2.28310004
67Abnormal tarsal ossification (HP:0008369)2.26862139
68Increased circulating renin level (HP:0000848)2.26821402
69Nephrolithiasis (HP:0000787)2.26182233
70Abnormality of nucleobase metabolism (HP:0010932)2.23788472
71Abnormality of glycine metabolism (HP:0010895)2.21583034
72Abnormality of serine family amino acid metabolism (HP:0010894)2.21583034
73Milia (HP:0001056)2.20534903
74Hyponatremia (HP:0002902)2.20113286
75Abnormality of monocarboxylic acid metabolism (HP:0010996)2.18098171
76Abnormality of sulfur amino acid metabolism (HP:0004339)2.16629704
77Abnormality of the middle phalanges of the toes (HP:0010183)2.15060784
78Enlarged epiphyses (HP:0010580)2.14403608
79Onion bulb formation (HP:0003383)2.12896541
80Abnormal auditory evoked potentials (HP:0006958)2.12332690
81Abnormality of dicarboxylic acid metabolism (HP:0010995)2.10808093
82Dicarboxylic aciduria (HP:0003215)2.10808093
83Hemorrhage of the eye (HP:0011885)2.10535579
84Symphalangism affecting the phalanges of the hand (HP:0009773)2.09756789
85Hypercholesterolemia (HP:0003124)2.08637450
86Subcapsular cataract (HP:0000523)2.07979431
87Peripheral demyelination (HP:0011096)2.07854025
88Pili torti (HP:0003777)2.07238621
89Thickened helices (HP:0000391)2.07229091
90Megaloblastic anemia (HP:0001889)2.06253519
91Protuberant abdomen (HP:0001538)2.05086356
92Syncope (HP:0001279)2.04062144
93Hypoglycemic coma (HP:0001325)2.02697337
94Hyperphosphaturia (HP:0003109)2.01886708
95Hypokalemia (HP:0002900)2.01808648
96Epidermoid cyst (HP:0200040)2.00540494
97Abnormality of potassium homeostasis (HP:0011042)2.00452771
98Abnormality of renin-angiotensin system (HP:0000847)1.99205951
99Abnormal biliary tract morphology (HP:0012440)1.97613525
100Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.97071494
101Abnormality of magnesium homeostasis (HP:0004921)1.96338774
102Focal segmental glomerulosclerosis (HP:0000097)1.93572824
103Abnormality of the distal phalanx of the thumb (HP:0009617)1.92759762
104Cerebral inclusion bodies (HP:0100314)1.92622594
105Renal tubular acidosis (HP:0001947)1.92620545
106Abnormal hair laboratory examination (HP:0003328)1.91453762
107Goiter (HP:0000853)1.91257398
108Spastic paraparesis (HP:0002313)1.89217604
109Insidious onset (HP:0003587)1.88609133
110Termporal pattern (HP:0011008)1.88609133
111Rickets (HP:0002748)1.87173133
112Hypokalemic alkalosis (HP:0001949)1.86756520
113Delayed epiphyseal ossification (HP:0002663)1.86566472
114Cardiovascular calcification (HP:0011915)1.86536880
115Late onset (HP:0003584)1.86520525
116Symptomatic seizures (HP:0011145)1.86408179
117Abnormal glucose tolerance (HP:0001952)1.86111127
118Hyperparathyroidism (HP:0000843)1.85153219
119Hyperaldosteronism (HP:0000859)1.84281139
120Neoplasm of the rectum (HP:0100743)1.82648080
121Hypoplasia of dental enamel (HP:0006297)1.82530314
122Pancreatitis (HP:0001733)1.82011644
123Stridor (HP:0010307)1.80871534
124Abnormal urine phosphate concentration (HP:0012599)1.80705832
125Irritability (HP:0000737)1.80016387
126Lethargy (HP:0001254)1.79250527
127Abnormality of pyrimidine metabolism (HP:0004353)1.79127920
128Abnormality of the gastric mucosa (HP:0004295)1.77671176
129Cone-rod dystrophy (HP:0000548)1.77471392
130Fragile nails (HP:0001808)1.77112647
131Abnormal gallbladder physiology (HP:0012438)1.77069866
132Cholecystitis (HP:0001082)1.77069866
133Curly hair (HP:0002212)1.76218228
134Palpitations (HP:0001962)1.74457878
135Abnormality of the 2nd finger (HP:0004100)1.72956733
136Glomerulosclerosis (HP:0000096)1.72623913
137Mildly elevated creatine phosphokinase (HP:0008180)1.70383823
138Alkalosis (HP:0001948)1.70315173
139Onycholysis (HP:0001806)1.69004905

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B7.37269627
2MST45.53956771
3FRK5.52435188
4STK393.92293126
5LMTK23.76808402
6MST1R3.68401129
7OXSR12.97710186
8MET2.77920118
9AKT32.58347606
10NME12.55808361
11EPHB12.49900008
12PRKG22.46831115
13ERN12.46667482
14MAP3K122.23124379
15WNK42.12049587
16MAP2K21.95221296
17MAP3K21.90854856
18EPHA21.85042859
19STK241.80950907
20PBK1.77596572
21KSR21.76374801
22NUAK11.67575883
23GRK61.61714138
24BCR1.61263375
25TNIK1.57680568
26PIK3CA1.53200492
27ERBB41.49831126
28TESK21.46997473
29LATS11.41859969
30LIMK11.36858492
31EIF2AK31.27159397
32RIPK11.26680387
33PTK61.25550924
34FGFR41.18984900
35BRSK21.13132485
36CAMK2D1.10703175
37CAMK2B1.10221681
38STK101.08491782
39NLK1.07959275
40ARAF1.03905801
41MAPKAPK51.01391666
42PAK30.98129120
43FGFR20.95891424
44TESK10.92567501
45TTK0.92451326
46PKN10.92320098
47PAK40.91899697
48WNK10.89901063
49TAOK30.88373146
50CAMK2G0.87059333
51FGFR30.86751137
52DDR20.83662411
53PRKCI0.82735246
54FER0.82713066
55CASK0.81497172
56PTK20.81110350
57EPHB20.80159149
58EPHA30.79219336
59YES10.78893461
60MAP3K90.75010729
61CSNK1A1L0.73897963
62SGK2230.71906737
63SGK4940.71906737
64PRKAA20.70318463
65BRAF0.69673379
66MAP3K80.67618341
67NEK10.65844722
68MAPK150.65623551
69EIF2AK10.65599218
70ROCK20.65369881
71ERBB30.64978447
72DMPK0.64849455
73ERBB20.63094700
74MAP2K10.61839106
75FGR0.61460450
76TRIM280.56969045
77PDPK10.55462183
78BMX0.54669698
79NEK60.54501743
80MAP3K10.53861579
81TAOK10.53583151
82NTRK10.52847362
83CSNK1G10.52563258
84CSNK1G30.50520755
85CSNK1A10.49867617
86MAP3K130.48771498
87MELK0.45943664
88GSK3A0.45808064
89MAPKAPK30.42935133
90IRAK10.42350123
91CDK190.41633549
92MAP3K70.41514662
93MATK0.41504815
94PRKACG0.41442051
95TYK20.41073964
96MAPK110.41008793
97ICK0.40990288
98PRKCQ0.40458581
99GRK10.40013239
100CAMK2A0.38757247
101BMPR1B0.38498281
102TRPM70.38169320
103STK30.37389783
104RPS6KB20.37305587
105PRPF4B0.36777709
106CDK50.36770140
107PDK20.35728262
108STK38L0.35287941
109PAK10.35253681
110ITK0.34930679
111PRKCE0.33762052
112CSNK1G20.32771957
113MUSK0.32285927
114TYRO30.32055717
115INSRR0.31154878
116BMPR20.30702520
117PRKD30.30067361
118MAPKAPK20.29787670
119MAP2K60.29758825
120PRKAA10.29356800
121PDK10.28279844
122SCYL20.27823125
123PRKCA0.27079543
124PRKD10.27035270
125SRC0.26972038
126MYLK0.25078318
127ABL20.24750058
128CDC42BPA0.24040590
129PRKCZ0.22923872
130MAP3K100.22907756
131CDK90.21271726
132MAP3K30.21157098
133EEF2K0.21142585
134AURKB0.19001000
135PIM10.17422569
136PRKCD0.15934555
137IGF1R0.15573924
138EPHA40.15381483
139PLK10.15335505
140RET0.13710655
141CDK60.12149120
142IRAK30.09356519

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049754.88022047
2Mineral absorption_Homo sapiens_hsa049784.13960553
3Vitamin digestion and absorption_Homo sapiens_hsa049773.75252768
4Renin-angiotensin system_Homo sapiens_hsa046143.74311253
5Sulfur metabolism_Homo sapiens_hsa009203.56667057
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.48777876
7Histidine metabolism_Homo sapiens_hsa003402.69170134
8Folate biosynthesis_Homo sapiens_hsa007902.59055494
9Caffeine metabolism_Homo sapiens_hsa002322.45624654
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.23010704
11Carbohydrate digestion and absorption_Homo sapiens_hsa049732.16381294
12Protein digestion and absorption_Homo sapiens_hsa049742.13568320
13Starch and sucrose metabolism_Homo sapiens_hsa005002.09794343
14Bile secretion_Homo sapiens_hsa049762.06004943
15Nitrogen metabolism_Homo sapiens_hsa009102.04664886
16Galactose metabolism_Homo sapiens_hsa000522.01545342
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.76230274
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.75745193
19Sphingolipid metabolism_Homo sapiens_hsa006001.74707234
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.71431489
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.68652044
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.67853822
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.66290477
24Glutathione metabolism_Homo sapiens_hsa004801.65996288
25Steroid biosynthesis_Homo sapiens_hsa001001.44250644
26Ether lipid metabolism_Homo sapiens_hsa005651.39069531
27Arginine and proline metabolism_Homo sapiens_hsa003301.36480354
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.32210272
29Fatty acid elongation_Homo sapiens_hsa000621.25761007
30Tryptophan metabolism_Homo sapiens_hsa003801.24175304
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.23107742
32Glycerolipid metabolism_Homo sapiens_hsa005611.19210596
33Linoleic acid metabolism_Homo sapiens_hsa005911.15061862
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11585319
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10668591
36Fructose and mannose metabolism_Homo sapiens_hsa000511.06969594
37PPAR signaling pathway_Homo sapiens_hsa033201.05476055
38Tight junction_Homo sapiens_hsa045301.02071173
39Chemical carcinogenesis_Homo sapiens_hsa052040.97154987
40Arginine biosynthesis_Homo sapiens_hsa002200.92908652
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92143175
42Cyanoamino acid metabolism_Homo sapiens_hsa004600.91844123
43Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90618726
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88416846
45Glycerophospholipid metabolism_Homo sapiens_hsa005640.86374951
46ABC transporters_Homo sapiens_hsa020100.86260268
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86240546
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84750490
49Fatty acid degradation_Homo sapiens_hsa000710.82631581
50beta-Alanine metabolism_Homo sapiens_hsa004100.82529411
51Retinol metabolism_Homo sapiens_hsa008300.75874857
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74438863
53Thyroid hormone synthesis_Homo sapiens_hsa049180.72727690
54Pancreatic secretion_Homo sapiens_hsa049720.70761913
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69993867
56Arachidonic acid metabolism_Homo sapiens_hsa005900.67765757
57Pyruvate metabolism_Homo sapiens_hsa006200.66760499
58Gastric acid secretion_Homo sapiens_hsa049710.65901304
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.62358969
60Butanoate metabolism_Homo sapiens_hsa006500.62147861
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59373669
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54457521
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.53105497
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52673965
65Vibrio cholerae infection_Homo sapiens_hsa051100.50344306
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49299914
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46698274
68Peroxisome_Homo sapiens_hsa041460.46341037
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45227811
70Fatty acid metabolism_Homo sapiens_hsa012120.40710466
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40703264
72Metabolic pathways_Homo sapiens_hsa011000.38815956
73Salivary secretion_Homo sapiens_hsa049700.36236425
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33990676
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.33292949
76Vitamin B6 metabolism_Homo sapiens_hsa007500.32149370
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32075596
78Biosynthesis of amino acids_Homo sapiens_hsa012300.31951789
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.28881747
80Asthma_Homo sapiens_hsa053100.28222862
81Inositol phosphate metabolism_Homo sapiens_hsa005620.26865981
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.25123405
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25012420
84Renin secretion_Homo sapiens_hsa049240.24642435
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.23968150
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23965423
87Insulin resistance_Homo sapiens_hsa049310.22794815
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.22279073
89Sulfur relay system_Homo sapiens_hsa041220.22045573
90Insulin secretion_Homo sapiens_hsa049110.21200185
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.20329778
92Ovarian steroidogenesis_Homo sapiens_hsa049130.19876674
93Dorso-ventral axis formation_Homo sapiens_hsa043200.19872718
94Propanoate metabolism_Homo sapiens_hsa006400.18443762
95Other glycan degradation_Homo sapiens_hsa005110.18213268
96Hepatitis C_Homo sapiens_hsa051600.17016885
97Salmonella infection_Homo sapiens_hsa051320.16453273
98Thyroid cancer_Homo sapiens_hsa052160.16080062
99African trypanosomiasis_Homo sapiens_hsa051430.14389690
100Long-term depression_Homo sapiens_hsa047300.14020826
101Pentose phosphate pathway_Homo sapiens_hsa000300.13575790
102N-Glycan biosynthesis_Homo sapiens_hsa005100.13567147
103Carbon metabolism_Homo sapiens_hsa012000.13373268
104Phenylalanine metabolism_Homo sapiens_hsa003600.13253285
105Choline metabolism in cancer_Homo sapiens_hsa052310.12907013
106Adherens junction_Homo sapiens_hsa045200.12874921
107Tyrosine metabolism_Homo sapiens_hsa003500.11351920
108Glucagon signaling pathway_Homo sapiens_hsa049220.11351708
109Type II diabetes mellitus_Homo sapiens_hsa049300.11215064
110Bladder cancer_Homo sapiens_hsa052190.10604532
111Cysteine and methionine metabolism_Homo sapiens_hsa002700.10449903
112Type I diabetes mellitus_Homo sapiens_hsa049400.10004528
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.09593512
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.09469325
115Fatty acid biosynthesis_Homo sapiens_hsa000610.08973173
116Complement and coagulation cascades_Homo sapiens_hsa046100.05760185
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.02593690
118Selenocompound metabolism_Homo sapiens_hsa004500.00560857
119Allograft rejection_Homo sapiens_hsa05330-0.0414739
120Serotonergic synapse_Homo sapiens_hsa04726-0.0316893

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