PLS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of integrated proviral latency (GO:0075713)4.42610179
2protein localization to kinetochore (GO:0034501)3.99286419
3nuclear pore complex assembly (GO:0051292)3.98205683
4ribosome assembly (GO:0042255)3.96942302
5nuclear pore organization (GO:0006999)3.79980430
6sequestering of extracellular ligand from receptor (GO:0035581)3.69062093
7cell adhesion mediated by integrin (GO:0033627)3.65233171
8chondrocyte proliferation (GO:0035988)3.63009467
9ventricular cardiac muscle cell development (GO:0055015)3.40490657
10establishment of viral latency (GO:0019043)3.39007910
11mitotic metaphase plate congression (GO:0007080)3.38977670
12paraxial mesoderm development (GO:0048339)3.38447552
13protein localization to chromosome, centromeric region (GO:0071459)3.35495772
14neuron projection extension involved in neuron projection guidance (GO:1902284)3.28090023
15axon extension involved in axon guidance (GO:0048846)3.28090023
16collagen fibril organization (GO:0030199)3.26596721
17metaphase plate congression (GO:0051310)3.17948664
18regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.15411435
19regulation of cardioblast differentiation (GO:0051890)3.12409466
20COPI coating of Golgi vesicle (GO:0048205)3.03048427
21Golgi transport vesicle coating (GO:0048200)3.03048427
22plasma membrane repair (GO:0001778)2.90254669
23protein complex localization (GO:0031503)2.87315102
24glutamate secretion (GO:0014047)2.84249667
25cellular protein complex localization (GO:0034629)2.82054884
26pore complex assembly (GO:0046931)2.80706350
27non-recombinational repair (GO:0000726)2.77361998
28double-strand break repair via nonhomologous end joining (GO:0006303)2.77361998
29proteasome assembly (GO:0043248)2.75497397
30CENP-A containing nucleosome assembly (GO:0034080)2.74438188
31mitotic sister chromatid cohesion (GO:0007064)2.71934344
32spindle checkpoint (GO:0031577)2.71412432
33mitotic sister chromatid segregation (GO:0000070)2.71315952
34lymph vessel development (GO:0001945)2.71312169
35regulation of transforming growth factor beta2 production (GO:0032909)2.69503615
36DNA unwinding involved in DNA replication (GO:0006268)2.67531992
37chromatin remodeling at centromere (GO:0031055)2.67504927
38synaptic vesicle docking involved in exocytosis (GO:0016081)2.66000569
39establishment of chromosome localization (GO:0051303)2.65663817
40regulation of axon extension involved in axon guidance (GO:0048841)2.65064451
41gap junction assembly (GO:0016264)2.64624569
42purine nucleobase biosynthetic process (GO:0009113)2.64209582
43vascular endothelial growth factor signaling pathway (GO:0038084)2.63929672
44regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.63924850
45sister chromatid segregation (GO:0000819)2.63341773
46retina vasculature morphogenesis in camera-type eye (GO:0061299)2.60634637
47endodermal cell differentiation (GO:0035987)2.59692785
48desmosome organization (GO:0002934)2.59283868
49bundle of His cell to Purkinje myocyte communication (GO:0086069)2.58239405
50response to X-ray (GO:0010165)2.56713534
51DNA strand elongation involved in DNA replication (GO:0006271)2.56078499
52cell migration involved in sprouting angiogenesis (GO:0002042)2.55596816
53protein heterotrimerization (GO:0070208)2.54542095
54IMP biosynthetic process (GO:0006188)2.53574880
55cullin deneddylation (GO:0010388)2.52981956
56notochord development (GO:0030903)2.52441770
57lymphangiogenesis (GO:0001946)2.52039104
58negative regulation of fibrinolysis (GO:0051918)2.51957273
59mitotic spindle checkpoint (GO:0071174)2.51948599
60protein localization to cell surface (GO:0034394)2.50584437
61positive regulation of axon extension (GO:0045773)2.49941892
62DNA strand elongation (GO:0022616)2.49602437
63regulation of mitotic spindle organization (GO:0060236)2.49153636
64synaptic vesicle maturation (GO:0016188)2.47506607
65metanephric mesenchyme development (GO:0072075)2.46478891
66mitotic nuclear envelope disassembly (GO:0007077)2.45877869
67nucleotide-sugar biosynthetic process (GO:0009226)2.45201468
68regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.44391983
69axon extension (GO:0048675)2.43817103
70regulation of tight junction assembly (GO:2000810)2.43434270
71vocalization behavior (GO:0071625)2.43291732
72negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.43008442
73hemidesmosome assembly (GO:0031581)2.42679020
74protein targeting to plasma membrane (GO:0072661)2.42652346
75anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.42041800
76anterior/posterior axis specification, embryo (GO:0008595)2.41636559
77regulation of axon guidance (GO:1902667)2.39915153
78regulation of helicase activity (GO:0051095)2.39893656
79skin morphogenesis (GO:0043589)2.39363651
80DNA ligation (GO:0006266)2.38698712
81protein deneddylation (GO:0000338)2.38293966
82nuclear envelope disassembly (GO:0051081)2.38072062
83membrane disassembly (GO:0030397)2.38072062
84DNA damage response, detection of DNA damage (GO:0042769)2.37913846
85heterochromatin organization (GO:0070828)2.35970634
86DNA replication checkpoint (GO:0000076)2.35659502
87L-serine metabolic process (GO:0006563)2.35233854
88tRNA aminoacylation for protein translation (GO:0006418)2.34813768
89negative regulation of axon extension involved in axon guidance (GO:0048843)2.34803902
90cell surface receptor signaling pathway involved in heart development (GO:0061311)2.34539333
91stress fiber assembly (GO:0043149)2.33395286
92IMP metabolic process (GO:0046040)2.33307252
93positive regulation of SMAD protein import into nucleus (GO:0060391)2.32344322
94negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.32288414
95negative regulation of mitotic sister chromatid segregation (GO:0033048)2.32288414
96negative regulation of mitotic sister chromatid separation (GO:2000816)2.32288414
97negative regulation of sister chromatid segregation (GO:0033046)2.32288414
98negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.32288414
99nucleobase biosynthetic process (GO:0046112)2.31829703
100endothelial cell morphogenesis (GO:0001886)2.31773390
101kidney mesenchyme development (GO:0072074)2.31629645
102regulation of chromosome segregation (GO:0051983)2.31408073
103negative regulation of ligase activity (GO:0051352)2.31347833
104negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.31347833
105negative regulation of chromosome segregation (GO:0051985)2.30783598
106regulation of spindle organization (GO:0090224)2.30733652
107regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.30638189
108positive regulation of cell size (GO:0045793)2.30247927
109epoxygenase P450 pathway (GO:0019373)2.29873960
110positive regulation of endothelial cell apoptotic process (GO:2000353)2.29131818
111amino acid activation (GO:0043038)2.29079920
112tRNA aminoacylation (GO:0043039)2.29079920
113mitotic chromosome condensation (GO:0007076)2.28741328
114negative regulation of keratinocyte proliferation (GO:0010839)2.28736470
115positive regulation of muscle hypertrophy (GO:0014742)2.27914923
116positive regulation of cardiac muscle hypertrophy (GO:0010613)2.27914923
117endocardial cushion development (GO:0003197)2.27843136
118glomerular basement membrane development (GO:0032836)2.27443430
119extracellular fibril organization (GO:0043206)2.27209799
120telomere maintenance via semi-conservative replication (GO:0032201)2.26675340
121dermatan sulfate biosynthetic process (GO:0030208)2.26283304
122substrate-dependent cell migration (GO:0006929)2.26125560
123cell fate commitment involved in formation of primary germ layer (GO:0060795)2.25951297
124synaptic vesicle exocytosis (GO:0016079)2.25606528
125mesodermal cell differentiation (GO:0048333)2.25496425
126maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.24611575
127regulation of translational fidelity (GO:0006450)2.24601522
128mitotic cytokinesis (GO:0000281)2.24591319
129positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.24041269
130spindle assembly checkpoint (GO:0071173)2.23969358
131histone exchange (GO:0043486)2.23796254
132positive regulation of fibroblast migration (GO:0010763)2.23204839
133positive regulation of vesicle fusion (GO:0031340)2.21712449
134regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.20842917
135negative regulation of chondrocyte differentiation (GO:0032331)2.20532900
136regulation of integrin-mediated signaling pathway (GO:2001044)2.19633534
137axonal fasciculation (GO:0007413)2.19237912
138negative regulation of complement activation (GO:0045916)2.19033834
139vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.18953929
140regulation of glomerular filtration (GO:0003093)2.17549812
141midgut development (GO:0007494)2.17453494
142establishment of nucleus localization (GO:0040023)2.17207948
143extracellular matrix assembly (GO:0085029)2.16414456
144protein localization to endosome (GO:0036010)2.16082148
145renal filtration (GO:0097205)2.15683053
146regulation of short-term neuronal synaptic plasticity (GO:0048172)2.13024552
147blood vessel endothelial cell migration (GO:0043534)2.12890284
148neuron projection extension (GO:1990138)2.12551489
149hippo signaling (GO:0035329)2.10794997
150wound healing, spreading of epidermal cells (GO:0035313)2.10258975
151dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.09985912
152negative regulation of protein activation cascade (GO:2000258)2.08941820
153negative regulation of catenin import into nucleus (GO:0035414)2.08194627
154regulation of fibrinolysis (GO:0051917)2.08129986
155peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.07875175
156negative regulation of fatty acid transport (GO:2000192)2.07667994
157neuron recognition (GO:0008038)2.06369676
158negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.05749706
159smooth muscle tissue development (GO:0048745)2.05057850
160basement membrane organization (GO:0071711)2.04851370
161locomotory exploration behavior (GO:0035641)2.03850759
162collagen metabolic process (GO:0032963)2.03527393
163positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.02655663
164negative regulation of axon guidance (GO:1902668)2.01438723
165fibrinolysis (GO:0042730)2.01334573
166negative regulation of sodium ion transport (GO:0010766)1.99885221
167glomerular visceral epithelial cell development (GO:0072015)1.99861228
168craniofacial suture morphogenesis (GO:0097094)1.98896565
169innervation (GO:0060384)1.98871041
170extracellular regulation of signal transduction (GO:1900115)1.97671908
171extracellular negative regulation of signal transduction (GO:1900116)1.97671908
172multicellular organismal macromolecule metabolic process (GO:0044259)1.97053625
173regulation of synaptic vesicle exocytosis (GO:2000300)1.96934604
174dermatan sulfate metabolic process (GO:0030205)1.96867853
175ganglion development (GO:0061548)1.96853393
176cytoskeletal anchoring at plasma membrane (GO:0007016)1.95937205
177membrane assembly (GO:0071709)1.95870381
178collagen catabolic process (GO:0030574)1.95839786
179artery development (GO:0060840)1.94920044
180chemical homeostasis within a tissue (GO:0048875)1.94866500
181epithelial cell-cell adhesion (GO:0090136)1.94560532
182lung vasculature development (GO:0060426)1.93947379
183regulation of transforming growth factor beta1 production (GO:0032908)1.93651196
184dendrite morphogenesis (GO:0048813)1.93350308
185positive regulation of cardiac muscle cell differentiation (GO:2000727)1.92581835

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.65984429
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.87624582
3AR_21909140_ChIP-Seq_LNCAP_Human3.13746258
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.05892276
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.00737358
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.92625574
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.88044868
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.70535381
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.67471625
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.61905453
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.43948137
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.40308337
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.35941026
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.31995740
15GBX2_23144817_ChIP-Seq_PC3_Human2.31412835
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.20013287
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.17389216
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.15741640
19* ELK1_19687146_ChIP-ChIP_HELA_Human2.15310265
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.12488985
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.12416020
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.12416020
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10279578
24* PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.07337781
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.05630154
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.04910345
27NRF2_20460467_ChIP-Seq_MEFs_Mouse2.02166435
28NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.02166435
29MYC_19030024_ChIP-ChIP_MESCs_Mouse1.99756781
30EZH2_22144423_ChIP-Seq_EOC_Human1.99619379
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99155288
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.96015738
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.95193441
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.93366418
35ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.92524227
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.89763024
37ZNF217_24962896_ChIP-Seq_MCF-7_Human1.88817524
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.87850159
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.85510453
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85122745
41EP300_21415370_ChIP-Seq_HL-1_Mouse1.84279373
42JARID2_20075857_ChIP-Seq_MESCs_Mouse1.81423151
43POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.80550061
44TP53_18474530_ChIP-ChIP_U2OS_Human1.80217716
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.79233708
46CLOCK_20551151_ChIP-Seq_293T_Human1.79052826
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78727586
48PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.78309501
49JARID2_20064375_ChIP-Seq_MESCs_Mouse1.75085363
50WT1_19549856_ChIP-ChIP_CCG9911_Human1.74776641
51EST1_17652178_ChIP-ChIP_JURKAT_Human1.74088664
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73413278
53E2F1_18555785_ChIP-Seq_MESCs_Mouse1.72048465
54HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.71277250
55* CJUN_26792858_Chip-Seq_BT549_Human1.70935260
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66258888
57SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.64200670
58JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.63575537
59NANOG_16153702_ChIP-ChIP_HESCs_Human1.63015152
60MYC_18358816_ChIP-ChIP_MESCs_Mouse1.58181060
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58079162
62DCP1A_22483619_ChIP-Seq_HELA_Human1.57312853
63* SOX17_20123909_ChIP-Seq_XEN_Mouse1.56942801
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55724571
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.55179893
66AR_21572438_ChIP-Seq_LNCaP_Human1.54699716
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54552039
68EZH2_27304074_Chip-Seq_ESCs_Mouse1.54313390
69ESR2_21235772_ChIP-Seq_MCF-7_Human1.54305245
70ESR1_20079471_ChIP-ChIP_T-47D_Human1.51383547
71SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.50101435
72FUS_26573619_Chip-Seq_HEK293_Human1.49130706
73NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.48069631
74TP53_16413492_ChIP-PET_HCT116_Human1.47189404
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46162184
76ETS1_20019798_ChIP-Seq_JURKAT_Human1.42577029
77ESR1_21235772_ChIP-Seq_MCF-7_Human1.41923462
78PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41500014
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41334862
80* RNF2_27304074_Chip-Seq_ESCs_Mouse1.40317196
81HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.38718183
82THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36945462
83E2F1_21310950_ChIP-Seq_MCF-7_Human1.36260311
84XRN2_22483619_ChIP-Seq_HELA_Human1.36158751
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.35641864
86* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.35407582
87SMAD4_21799915_ChIP-Seq_A2780_Human1.32213082
88CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.31375121
89POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31304227
90RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31109725
91RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31098627
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29087202
93AHR_22903824_ChIP-Seq_MCF-7_Human1.28514077
94FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28290687
95ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.27699135
96* TTF2_22483619_ChIP-Seq_HELA_Human1.27423788
97NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27224447
98TCF3_18692474_ChIP-Seq_MEFs_Mouse1.27176686
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.27156070
100BCAT_22108803_ChIP-Seq_LS180_Human1.26841595
101* SOX2_20726797_ChIP-Seq_SW620_Human1.24579719
102EZH2_27294783_Chip-Seq_ESCs_Mouse1.24531929
103SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24050729
104OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23900857
105SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23126585
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22968993
107CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22853404
108* EWS_26573619_Chip-Seq_HEK293_Human1.21878720
109NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21822403
110* P300_19829295_ChIP-Seq_ESCs_Human1.17419313
111NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17190908
112SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17106684
113ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16412739
114* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15710267
115GATA2_21666600_ChIP-Seq_HMVEC_Human1.15514107
116SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.14965795
117TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13706234
118EOMES_21245162_ChIP-Seq_HESCs_Human1.13448139
119ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13135914
120RXR_22108803_ChIP-Seq_LS180_Human1.12751540
121EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.12631046
122POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12070256
123TCF4_18268006_ChIP-ChIP_LS174T_Human1.10876424
124SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10475056
125TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09260201
126TP53_20018659_ChIP-ChIP_R1E_Mouse1.09026623
127SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08751247
128DROSHA_22980978_ChIP-Seq_HELA_Human1.08493600
129TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08418838
130TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.08285003
131ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08082935
132WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08081771
133BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05850609
134NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.05826794
135BRD4_25478319_ChIP-Seq_HGPS_Human1.05730588
136NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05673354
137SOX2_16153702_ChIP-ChIP_HESCs_Human1.05533459
138TAF15_26573619_Chip-Seq_HEK293_Human1.05332294
139SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05063242
140HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04539208
141GABP_19822575_ChIP-Seq_HepG2_Human1.03492099
142AR_25329375_ChIP-Seq_VCAP_Human1.03055728
143FOXO3_23340844_ChIP-Seq_DLD1_Human1.02430327
144SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02052814
145LXR_22158963_ChIP-Seq_LIVER_Mouse1.01473860
146TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00863492
147TP63_23658742_ChIP-Seq_EP156T_Human1.00050035
148TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99853194
149ELK1_22589737_ChIP-Seq_MCF10A_Human0.99804402
150ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99696639
151SMAD3_21741376_ChIP-Seq_EPCs_Human0.98561911
152HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.98411131
153SMAD3_21741376_ChIP-Seq_HESCs_Human0.97915133
154CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97639883
155TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96925903
156CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.96041072
157ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95906217
158RXR_22158963_ChIP-Seq_LIVER_Mouse0.95570041
159CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94726959
160* SOX2_21211035_ChIP-Seq_LN229_Gbm0.94646632
161HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94619160
162ERG_21242973_ChIP-ChIP_JURKAT_Human0.94592603
163NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.94439304
164CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94378291
165EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94357433
166* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.94251204
167* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.94251204
168* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93828635
169NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93084710
170SMAD4_21741376_ChIP-Seq_HESCs_Human0.92936881
171KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92166000
172ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.91213050
173RING1B_27294783_Chip-Seq_ESCs_Mouse0.90781987
174NANOG_21062744_ChIP-ChIP_HESCs_Human0.90015290
175* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89728288
176TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89719255
177CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88982373
178DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88743467
179NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.88041170
180POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88003123

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.96024219
2MP0005275_abnormal_skin_tensile4.06891799
3MP0005503_abnormal_tendon_morphology3.42908160
4MP0003705_abnormal_hypodermis_morpholog3.12016634
5MP0004272_abnormal_basement_membrane3.01746697
6MP0000537_abnormal_urethra_morphology2.65625154
7MP0004859_abnormal_synaptic_plasticity2.65525705
8MP0001958_emphysema2.63621356
9MP0005623_abnormal_meninges_morphology2.53670303
10MP0010368_abnormal_lymphatic_system2.51577396
11MP0009384_cardiac_valve_regurgitation2.36042288
12MP0003279_aneurysm2.33049596
13MP0004957_abnormal_blastocyst_morpholog2.18227744
14MP0010352_gastrointestinal_tract_polyps2.12955271
15MP0002295_abnormal_pulmonary_circulatio2.04762481
16MP0008932_abnormal_embryonic_tissue1.97308422
17MP0001879_abnormal_lymphatic_vessel1.90449719
18MP0010094_abnormal_chromosome_stability1.88581070
19MP0003111_abnormal_nucleus_morphology1.86815397
20MP0009697_abnormal_copulation1.86642618
21MP0009780_abnormal_chondrocyte_physiolo1.84802423
22MP0010234_abnormal_vibrissa_follicle1.84774504
23MP0000013_abnormal_adipose_tissue1.82237605
24MP0003693_abnormal_embryo_hatching1.80509435
25MP0003937_abnormal_limbs/digits/tail_de1.78418740
26MP0005257_abnormal_intraocular_pressure1.69622728
27MP0000534_abnormal_ureter_morphology1.68451175
28MP0003950_abnormal_plasma_membrane1.64913540
29MP0010386_abnormal_urinary_bladder1.64900215
30MP0002697_abnormal_eye_size1.63757636
31MP0008058_abnormal_DNA_repair1.62913556
32MP0002877_abnormal_melanocyte_morpholog1.61410858
33MP0003566_abnormal_cell_adhesion1.58410743
34MP0003091_abnormal_cell_migration1.53560186
35MP0003077_abnormal_cell_cycle1.53388246
36MP0001542_abnormal_bone_strength1.52656713
37MP0008007_abnormal_cellular_replicative1.48203728
38MP0004858_abnormal_nervous_system1.46075864
39MP0002084_abnormal_developmental_patter1.43292671
40MP0002254_reproductive_system_inflammat1.40150858
41MP0003880_abnormal_central_pattern1.39135013
42MP0002735_abnormal_chemical_nociception1.38048684
43MP0001177_atelectasis1.37978491
44MP0009250_abnormal_appendicular_skeleto1.37389299
45MP0003385_abnormal_body_wall1.37249761
46MP0000049_abnormal_middle_ear1.35373826
47MP0009053_abnormal_anal_canal1.35029892
48MP0001299_abnormal_eye_distance/1.34452161
49MP0005508_abnormal_skeleton_morphology1.33610389
50MP0001730_embryonic_growth_arrest1.32931770
51MP0003890_abnormal_embryonic-extraembry1.32457818
52MP0003635_abnormal_synaptic_transmissio1.31974867
53MP0002234_abnormal_pharynx_morphology1.30510004
54MP0002060_abnormal_skin_morphology1.29519070
55MP0004883_abnormal_blood_vessel1.29282166
56MP0001293_anophthalmia1.29161351
57MP0002896_abnormal_bone_mineralization1.28734701
58MP0005595_abnormal_vascular_smooth1.26859088
59MP0001672_abnormal_embryogenesis/_devel1.25957832
60MP0005380_embryogenesis_phenotype1.25957832
61MP0002108_abnormal_muscle_morphology1.25676418
62MP0002168_other_aberrant_phenotype1.23588835
63MP0002282_abnormal_trachea_morphology1.22773104
64MP0002085_abnormal_embryonic_tissue1.22452255
65MP0001968_abnormal_touch/_nociception1.20942530
66MP0003935_abnormal_craniofacial_develop1.18716280
67MP0002736_abnormal_nociception_after1.18259895
68MP0003984_embryonic_growth_retardation1.16403788
69MP0002837_dystrophic_cardiac_calcinosis1.16019406
70MP0003329_amyloid_beta_deposits1.14654662
71MP0000767_abnormal_smooth_muscle1.12588890
72MP0003119_abnormal_digestive_system1.12019388
73MP0003942_abnormal_urinary_system1.11903986
74MP0005367_renal/urinary_system_phenotyp1.11889722
75MP0000516_abnormal_urinary_system1.11889722
76MP0002088_abnormal_embryonic_growth/wei1.11618519
77MP0004270_analgesia1.11194961
78MP0000350_abnormal_cell_proliferation1.10113156
79MP0001286_abnormal_eye_development1.09957790
80MP0002063_abnormal_learning/memory/cond1.07114565
81MP0005164_abnormal_response_to1.06916396
82MP0005023_abnormal_wound_healing1.06432196
83MP0006054_spinal_hemorrhage1.06133355
84MP0005197_abnormal_uvea_morphology1.05749189
85MP0000467_abnormal_esophagus_morphology1.05435634
86MP0006138_congestive_heart_failure1.05362728
87MP0005501_abnormal_skin_physiology1.03915024
88MP0002102_abnormal_ear_morphology1.03471657
89MP0008057_abnormal_DNA_replication1.03466164
90MP0004484_altered_response_of1.02480841
91MP0000428_abnormal_craniofacial_morphol1.02342732
92MP0002092_abnormal_eye_morphology1.00969727
93MP0001697_abnormal_embryo_size1.00765590
94MP0002133_abnormal_respiratory_system1.00582495
95MP0005388_respiratory_system_phenotype1.00582495
96MP0008789_abnormal_olfactory_epithelium1.00435278
97MP0005085_abnormal_gallbladder_physiolo0.99913369
98MP0005171_absent_coat_pigmentation0.99347172
99MP0003941_abnormal_skin_development0.98977716
100MP0002111_abnormal_tail_morphology0.98303830
101MP0003315_abnormal_perineum_morphology0.98259141
102MP0002796_impaired_skin_barrier0.97634752
103MP0002139_abnormal_hepatobiliary_system0.97288132
104MP0000432_abnormal_head_morphology0.96600037
105MP0000538_abnormal_urinary_bladder0.95826265
106MP0009672_abnormal_birth_weight0.95529868
107MP0010030_abnormal_orbit_morphology0.95179376
108MP0001915_intracranial_hemorrhage0.94761303
109MP0002080_prenatal_lethality0.94387370
110MP0009745_abnormal_behavioral_response0.93792418
111MP0002086_abnormal_extraembryonic_tissu0.93539460
112MP0000751_myopathy0.92485894
113MP0004197_abnormal_fetal_growth/weight/0.92075400
114MP0000647_abnormal_sebaceous_gland0.90663117
115MP0003252_abnormal_bile_duct0.90344948
116MP0003045_fibrosis0.89587852
117MP0001849_ear_inflammation0.87861019
118MP0003786_premature_aging0.87702551
119MP0003718_maternal_effect0.87668366
120MP0005360_urolithiasis0.86953859
121MP0000762_abnormal_tongue_morphology0.86922500
122MP0002938_white_spotting0.86464578
123MP0003115_abnormal_respiratory_system0.85318330
124MP0008875_abnormal_xenobiotic_pharmacok0.84667381
125MP0002064_seizures0.84440971
126MP0000163_abnormal_cartilage_morphology0.84015300
127MP0002177_abnormal_outer_ear0.83774381
128MP0001661_extended_life_span0.82711800
129MP0003567_abnormal_fetal_cardiomyocyte0.80170968
130MP0000462_abnormal_digestive_system0.79934312
131MP0002115_abnormal_skeleton_extremities0.79794609
132MP0010771_integument_phenotype0.78644846
133MP0005187_abnormal_penis_morphology0.78454097
134MP0004782_abnormal_surfactant_physiolog0.78441810
135MP0005620_abnormal_muscle_contractility0.76633505
136MP0004084_abnormal_cardiac_muscle0.76372720
137MP0005167_abnormal_blood-brain_barrier0.74642467
138MP0000579_abnormal_nail_morphology0.73819021
139MP0002972_abnormal_cardiac_muscle0.73759963
140MP0002128_abnormal_blood_circulation0.72717294
141MP0001440_abnormal_grooming_behavior0.72531898
142MP0003755_abnormal_palate_morphology0.72037752
143MP0010678_abnormal_skin_adnexa0.70910439
144MP0003195_calcinosis0.70396904
145MP0000778_abnormal_nervous_system0.69951195
146MP0005165_increased_susceptibility_to0.69323751
147MP0001346_abnormal_lacrimal_gland0.68626849
148MP0002572_abnormal_emotion/affect_behav0.68621714
149MP0002734_abnormal_mechanical_nocicepti0.68621328
150MP0004233_abnormal_muscle_weight0.68373201
151MP0003283_abnormal_digestive_organ0.67586836
152MP0001501_abnormal_sleep_pattern0.67463564
153MP0008004_abnormal_stomach_pH0.66925716
154MP0001243_abnormal_dermal_layer0.66850797
155MP0004134_abnormal_chest_morphology0.64532024
156MP0002233_abnormal_nose_morphology0.64113084
157MP0000604_amyloidosis0.63134435

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.22581273
2Premature rupture of membranes (HP:0001788)4.92779888
3Aortic aneurysm (HP:0004942)4.00775719
4Aortic dissection (HP:0002647)3.59924351
5Atrophic scars (HP:0001075)3.53743292
6Vascular tortuosity (HP:0004948)3.39017788
7Spastic diplegia (HP:0001264)3.34346251
8Broad metatarsal (HP:0001783)3.23798160
9Shallow orbits (HP:0000586)3.22948309
10Selective tooth agenesis (HP:0001592)3.16734302
11Dilatation of the ascending aorta (HP:0005111)2.94765628
12Abnormality of dentin (HP:0010299)2.85287061
13Cerebral aneurysm (HP:0004944)2.74960689
14Right ventricular cardiomyopathy (HP:0011663)2.68019978
15Overgrowth (HP:0001548)2.65836740
16Cortical dysplasia (HP:0002539)2.61904424
17Peritonitis (HP:0002586)2.60622185
18Spinal rigidity (HP:0003306)2.60113284
19Wormian bones (HP:0002645)2.58066792
20Fragile skin (HP:0001030)2.56519876
21Arterial tortuosity (HP:0005116)2.46017432
22Ankle contracture (HP:0006466)2.44776417
23Deep venous thrombosis (HP:0002625)2.43478926
24Bladder diverticulum (HP:0000015)2.41982680
25Aplasia involving bones of the extremities (HP:0009825)2.38809506
26Aplasia involving bones of the upper limbs (HP:0009823)2.38809506
27Aplasia of the phalanges of the hand (HP:0009802)2.38809506
28Focal motor seizures (HP:0011153)2.34486741
29Mitral valve prolapse (HP:0001634)2.32304406
30Soft skin (HP:0000977)2.29244332
31Neonatal short-limb short stature (HP:0008921)2.28299362
32Abnormality of the umbilical cord (HP:0010881)2.27307997
33Cervical subluxation (HP:0003308)2.25334713
34Short hallux (HP:0010109)2.25011177
35Abnormality of the fetal cardiovascular system (HP:0010948)2.25011071
36Abnormal umbilical cord blood vessels (HP:0011403)2.25011071
37Single umbilical artery (HP:0001195)2.25011071
38Mitral stenosis (HP:0001718)2.24301624
39Follicular hyperkeratosis (HP:0007502)2.23398982
40Atonic seizures (HP:0010819)2.19590707
41Deviation of the thumb (HP:0009603)2.17747418
42Focal seizures (HP:0007359)2.16956393
43Facial cleft (HP:0002006)2.16572210
44Increased connective tissue (HP:0009025)2.15184323
45Coronal craniosynostosis (HP:0004440)2.15174461
46Bronchomalacia (HP:0002780)2.13273149
47Buphthalmos (HP:0000557)2.12609266
48Aneurysm (HP:0002617)2.07492605
49Hyperextensible skin (HP:0000974)2.06838983
50Camptodactyly of toe (HP:0001836)2.06781680
51Blue sclerae (HP:0000592)2.06229393
52Proximal placement of thumb (HP:0009623)2.05480646
53Aplasia/Hypoplasia of the hallux (HP:0008362)2.05165059
54Increased variability in muscle fiber diameter (HP:0003557)2.04570047
55Wide anterior fontanel (HP:0000260)2.04288610
56Abnormalities of placenta or umbilical cord (HP:0001194)2.03102677
57Short nail (HP:0001799)1.99272232
58Cerebral inclusion bodies (HP:0100314)1.98231121
59Infantile muscular hypotonia (HP:0008947)1.97157867
60Vertebral compression fractures (HP:0002953)1.97123499
61Reduced subcutaneous adipose tissue (HP:0003758)1.93169054
62Absent eyelashes (HP:0000561)1.92644100
63Cardiovascular calcification (HP:0011915)1.92284337
64Type 1 muscle fiber predominance (HP:0003803)1.92258934
65Ulnar bowing (HP:0003031)1.92167219
66Hypoplastic pelvis (HP:0008839)1.90681356
67Myokymia (HP:0002411)1.90088076
68Bifid tongue (HP:0010297)1.88610144
69Abnormal delivery (HP:0001787)1.88182300
70Wrist flexion contracture (HP:0001239)1.86050070
71Pterygium (HP:0001059)1.84658316
72Round ear (HP:0100830)1.82890853
73Natal tooth (HP:0000695)1.81935752
74Biconcave vertebral bodies (HP:0004586)1.81493445
75Striae distensae (HP:0001065)1.81053528
76Scapular winging (HP:0003691)1.80423202
77Genu recurvatum (HP:0002816)1.80414732
78Fragile nails (HP:0001808)1.79362440
79Increased serum pyruvate (HP:0003542)1.78479244
80Focal segmental glomerulosclerosis (HP:0000097)1.78145262
81Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.77554212
82Venous insufficiency (HP:0005293)1.76751481
83Action tremor (HP:0002345)1.75043027
84Increased nuchal translucency (HP:0010880)1.74472415
85Venous abnormality (HP:0002624)1.74192034
86Ectopia lentis (HP:0001083)1.74082781
87Abnormality of the anterior chamber (HP:0000593)1.73478391
88Hypoventilation (HP:0002791)1.73351439
89Osteoarthritis (HP:0002758)1.72206614
90Back pain (HP:0003418)1.71815465
91Abnormality of the distal phalanges of the toes (HP:0010182)1.70877640
92Neurofibrillary tangles (HP:0002185)1.70765236
93Trismus (HP:0000211)1.70669129
94Chromosomal breakage induced by crosslinking agents (HP:0003221)1.70504003
95Abnormal lung lobation (HP:0002101)1.69700238
96Sparse eyelashes (HP:0000653)1.67950181
97Split foot (HP:0001839)1.66958192
98Abnormality of glycolysis (HP:0004366)1.66740394
99Bell-shaped thorax (HP:0001591)1.66420113
100Stenosis of the external auditory canal (HP:0000402)1.66078485
101Shoulder girdle muscle weakness (HP:0003547)1.65916970
102Tarsal synostosis (HP:0008368)1.65820536
103Myelomeningocele (HP:0002475)1.65286086
104Abnormal number of incisors (HP:0011064)1.65025545
105Delayed gross motor development (HP:0002194)1.64860025
106Knee flexion contracture (HP:0006380)1.62501573
107Absent phalangeal crease (HP:0006109)1.62085927
108Abnormality of skeletal muscle fiber size (HP:0012084)1.61336289
109Osteolytic defects of the phalanges of the hand (HP:0009771)1.61109391
110Osteolytic defects of the hand bones (HP:0009699)1.61109391
111Abnormality of the Achilles tendon (HP:0005109)1.60452849
112Hyperventilation (HP:0002883)1.60257859
113Bowel diverticulosis (HP:0005222)1.59974315
114Delayed cranial suture closure (HP:0000270)1.59787785
115Aplasia/hypoplasia of the humerus (HP:0006507)1.59725309
116Bifid uvula (HP:0000193)1.59684644
117Abnormality of the astrocytes (HP:0100707)1.59616117
118Astrocytoma (HP:0009592)1.59616117
119Ependymoma (HP:0002888)1.59593626
120Absent eyebrow (HP:0002223)1.59162765
121Short middle phalanx of the 5th finger (HP:0004220)1.58417910
122Absence seizures (HP:0002121)1.58261095
123Chromsome breakage (HP:0040012)1.58106484
124Onycholysis (HP:0001806)1.56961312
125Short clavicles (HP:0000894)1.56760631
126Achilles tendon contracture (HP:0001771)1.56608255
127Absent frontal sinuses (HP:0002688)1.55397236
128Abnormality of the calcaneus (HP:0008364)1.53634547
129Abnormality of the intrinsic pathway (HP:0010989)1.53466654
130Termporal pattern (HP:0011008)1.52203844
131Insidious onset (HP:0003587)1.52203844
132Elbow flexion contracture (HP:0002987)1.52009440
133Spontaneous abortion (HP:0005268)1.51951196
134Torticollis (HP:0000473)1.51931320
135Mildly elevated creatine phosphokinase (HP:0008180)1.51530015
136Lymphangioma (HP:0100764)1.51482986
137Hydroureter (HP:0000072)1.50630874
138Glomerulosclerosis (HP:0000096)1.50547062
139Abnormal finger flexion creases (HP:0006143)1.50223750
140Synostosis involving bones of the feet (HP:0009140)1.50036275
141Synostosis involving bones of the lower limbs (HP:0009138)1.50036275
142Medulloblastoma (HP:0002885)1.49403085
143Embryonal renal neoplasm (HP:0011794)1.49181653
144Abnormality of proline metabolism (HP:0010907)1.49098154
145Hydroxyprolinuria (HP:0003080)1.49098154
146Abnormality of the musculature of the pelvis (HP:0001469)1.48878009
147Abnormality of the hip-girdle musculature (HP:0001445)1.48878009
148Hyporeflexia of lower limbs (HP:0002600)1.48620947
149Abnormality of methionine metabolism (HP:0010901)1.48423073
150Long toe (HP:0010511)1.48381418
151Rhizomelia (HP:0008905)1.48197282
152Vertebral clefting (HP:0008428)1.48097348
153Deviation of the hallux (HP:0010051)1.47767441
154Omphalocele (HP:0001539)1.47064766
155Aplasia/Hypoplasia of the clavicles (HP:0006710)1.46664786
156Fused cervical vertebrae (HP:0002949)1.44295562
157Glossoptosis (HP:0000162)1.43907596
158Short humerus (HP:0005792)1.43797822
159Multiple enchondromatosis (HP:0005701)1.43746879
160Abnormality of pain sensation (HP:0010832)1.43372204
161Impaired pain sensation (HP:0007328)1.43372204
162Entropion (HP:0000621)1.43097271
163Nephroblastoma (Wilms tumor) (HP:0002667)1.43093803
164Abnormal auditory evoked potentials (HP:0006958)1.42451718
165Hepatoblastoma (HP:0002884)1.42349604
166Microglossia (HP:0000171)1.42126131
167Protruding ear (HP:0000411)1.40573994
168Alopecia of scalp (HP:0002293)1.40531733
169Calcaneovalgus deformity (HP:0001848)1.39707707
170Skull defect (HP:0001362)1.38951930
171Gout (HP:0001997)1.36902225

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.32701606
2SRPK13.04512640
3TSSK62.90564513
4FER2.82227441
5PBK2.79884009
6LATS22.59227849
7TTK2.46631333
8NEK12.46361667
9DDR22.42703747
10NTRK32.39054397
11PLK22.34568317
12EPHA42.34003250
13PTK2B2.33571675
14EPHB22.21446493
15PLK32.07437716
16BRSK22.05278775
17PDGFRA2.02548434
18MAP3K42.00405315
19MINK11.94272062
20EIF2AK11.91534208
21MYLK1.91380107
22FRK1.89676951
23TRIM281.89586385
24TTN1.86394449
25MAP3K121.85498490
26PAK31.83512379
27CDC71.83106542
28LIMK11.78939452
29ERBB31.75351853
30LATS11.74491111
31MAP2K41.73129609
32WEE11.70633313
33MAP3K91.66625696
34EIF2AK31.64245396
35MKNK11.62076306
36PLK41.60678579
37KSR21.55696921
38NTRK11.54087038
39PNCK1.48914199
40MAP2K71.45859805
41VRK21.43202875
42TESK11.40953950
43PTK21.38779194
44PRKD31.37693001
45MAP2K11.36649109
46FGFR21.36105246
47BRSK11.33694572
48PAK61.33154640
49MKNK21.31676042
50DAPK21.27006443
51STK161.23887753
52BCR1.23350024
53PLK11.23263023
54MAP3K21.22800108
55KSR11.22353608
56GRK51.14037158
57CASK1.10967784
58TIE11.09899676
59EPHA21.08322078
60PAK21.05525457
61STK38L1.04812810
62LMTK21.04136447
63ROCK11.02854606
64MET1.02206270
65CSNK1G11.01396261
66NEK91.01044201
67SCYL21.00804586
68WNK30.99810910
69RIPK10.98104939
70AKT30.97880441
71AURKB0.95304322
72ARAF0.94612806
73PIK3CA0.93986090
74CSNK1A1L0.93819002
75PRKCE0.92253289
76TRPM70.91667977
77CSNK1G30.90669385
78MOS0.88284518
79PDK20.88250750
80PRKCH0.87811055
81RET0.84633246
82PRPF4B0.83606787
83TAF10.80956472
84CAMK2A0.80706871
85ROCK20.80367807
86BRD40.80233831
87OXSR10.78530355
88RPS6KA40.77943097
89STK30.77521989
90PDGFRB0.77230535
91ERBB40.76896028
92FGFR10.76665814
93TRIB30.75104206
94CSNK1G20.74442933
95DMPK0.73907535
96KDR0.73417530
97STK390.72870914
98CDK50.72660837
99BMX0.71683871
100MST40.70252820
101VRK10.70213386
102CDK140.69927616
103SIK10.68336608
104CAMKK10.68191707
105PTK60.67867355
106EIF2AK20.67380257
107MST1R0.67321623
108FLT30.66748335
109CHEK20.66503485
110TGFBR20.66425141
111CAMK2B0.66401587
112PRKCG0.65064690
113CDK60.64100210
114CDK80.63340778
115STK380.62753017
116BMPR20.62363676
117ZAK0.62274652
118WNK40.60949151
119CHEK10.60886656
120STK100.59704466
121CDK180.59065168
122CDK70.57158766
123EPHA30.56721493
124NME10.56663019
125ATM0.56399377
126STK240.56206993
127ADRBK10.55416223
128CDK150.54231197
129PDK40.53680993
130PDK30.53680993
131ATR0.53664398
132INSR0.52942333
133CAMK2G0.51570189
134MAP3K10.50366978
135SGK2230.48819222
136SGK4940.48819222
137AURKA0.48816786
138SRC0.48585837
139NEK20.48250755
140WNK10.47945910
141PAK40.47853837
142BRAF0.47310927
143CAMK2D0.46030824
144TGFBR10.45976459
145ABL20.45889066
146TAOK20.44891872
147DAPK30.43238530
148PIK3CG0.42971219
149LRRK20.42945031
150CDK90.42700449
151PRKD10.42072249
152BMPR1B0.41512669
153AKT20.36527189
154ALK0.36317852
155MAP3K80.35691276
156CSNK1E0.35562463
157NME20.35098828
158CDK120.34813855
159CDK10.34160332

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030502.93332736
2Mismatch repair_Homo sapiens_hsa034302.78627711
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.64552018
4DNA replication_Homo sapiens_hsa030302.53502033
5Non-homologous end-joining_Homo sapiens_hsa034502.45776294
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.30125611
7ECM-receptor interaction_Homo sapiens_hsa045122.05879231
8Cell cycle_Homo sapiens_hsa041101.87519482
9RNA transport_Homo sapiens_hsa030131.87429593
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.86198069
11Nucleotide excision repair_Homo sapiens_hsa034201.79584725
12Nitrogen metabolism_Homo sapiens_hsa009101.77946249
13Biosynthesis of amino acids_Homo sapiens_hsa012301.71293386
14Synaptic vesicle cycle_Homo sapiens_hsa047211.71237245
15Spliceosome_Homo sapiens_hsa030401.67921489
16Cysteine and methionine metabolism_Homo sapiens_hsa002701.67365994
17Focal adhesion_Homo sapiens_hsa045101.66836624
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.64190810
19Protein export_Homo sapiens_hsa030601.57808329
20Nicotine addiction_Homo sapiens_hsa050331.55988977
21Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.50630296
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.48701540
23Dilated cardiomyopathy_Homo sapiens_hsa054141.42776657
24Long-term potentiation_Homo sapiens_hsa047201.41024583
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.38748441
26One carbon pool by folate_Homo sapiens_hsa006701.38366647
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37984117
28RNA polymerase_Homo sapiens_hsa030201.34450946
29Propanoate metabolism_Homo sapiens_hsa006401.34311638
30Carbon metabolism_Homo sapiens_hsa012001.34029123
31Circadian entrainment_Homo sapiens_hsa047131.33997508
32Axon guidance_Homo sapiens_hsa043601.33111044
33Base excision repair_Homo sapiens_hsa034101.31633116
34Amphetamine addiction_Homo sapiens_hsa050311.30141852
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29199392
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28832261
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28427635
38Salivary secretion_Homo sapiens_hsa049701.28138194
39Adherens junction_Homo sapiens_hsa045201.26744480
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.26299569
41Fatty acid elongation_Homo sapiens_hsa000621.25847925
42Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.25755056
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.25311516
44Renin secretion_Homo sapiens_hsa049241.20665698
45Basal cell carcinoma_Homo sapiens_hsa052171.20607414
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.20465653
47Selenocompound metabolism_Homo sapiens_hsa004501.20011351
48Arginine biosynthesis_Homo sapiens_hsa002201.19905598
49Complement and coagulation cascades_Homo sapiens_hsa046101.17779737
50Basal transcription factors_Homo sapiens_hsa030221.17454219
51Proteoglycans in cancer_Homo sapiens_hsa052051.17414976
52GABAergic synapse_Homo sapiens_hsa047271.17134985
53Homologous recombination_Homo sapiens_hsa034401.14652223
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14298901
55Steroid biosynthesis_Homo sapiens_hsa001001.14118349
56Gap junction_Homo sapiens_hsa045401.14027327
57Hedgehog signaling pathway_Homo sapiens_hsa043401.13046792
58Vibrio cholerae infection_Homo sapiens_hsa051101.11804948
59Gastric acid secretion_Homo sapiens_hsa049711.11554403
60Amoebiasis_Homo sapiens_hsa051461.11414486
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10433062
62Pyrimidine metabolism_Homo sapiens_hsa002401.09556668
63Dopaminergic synapse_Homo sapiens_hsa047281.08400793
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07531020
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.06988105
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06470106
67Hippo signaling pathway_Homo sapiens_hsa043901.06123470
68GnRH signaling pathway_Homo sapiens_hsa049121.06047467
69Collecting duct acid secretion_Homo sapiens_hsa049661.05834707
70Glioma_Homo sapiens_hsa052141.05776670
71Glutamatergic synapse_Homo sapiens_hsa047241.04481398
72Melanogenesis_Homo sapiens_hsa049161.03254252
73Fanconi anemia pathway_Homo sapiens_hsa034601.02048796
74mRNA surveillance pathway_Homo sapiens_hsa030151.00975866
75p53 signaling pathway_Homo sapiens_hsa041151.00798525
76Oxytocin signaling pathway_Homo sapiens_hsa049211.00517486
77Bile secretion_Homo sapiens_hsa049760.99819251
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.99617574
79Olfactory transduction_Homo sapiens_hsa047400.99007495
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.98463013
81Folate biosynthesis_Homo sapiens_hsa007900.97261344
82TGF-beta signaling pathway_Homo sapiens_hsa043500.96521995
83Long-term depression_Homo sapiens_hsa047300.96271891
84Tight junction_Homo sapiens_hsa045300.95800775
85Rap1 signaling pathway_Homo sapiens_hsa040150.93821989
86Vitamin B6 metabolism_Homo sapiens_hsa007500.92346259
87Chemical carcinogenesis_Homo sapiens_hsa052040.91977965
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91687054
89Taste transduction_Homo sapiens_hsa047420.91590364
90Small cell lung cancer_Homo sapiens_hsa052220.91561053
91Thyroid hormone synthesis_Homo sapiens_hsa049180.91473395
92Morphine addiction_Homo sapiens_hsa050320.90093061
93RNA degradation_Homo sapiens_hsa030180.88792880
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88400577
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88359816
96Serotonergic synapse_Homo sapiens_hsa047260.86914969
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85941771
98beta-Alanine metabolism_Homo sapiens_hsa004100.85446826
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85285776
100Bladder cancer_Homo sapiens_hsa052190.84645096
101Oocyte meiosis_Homo sapiens_hsa041140.84420539
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82999949
103Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82459956
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81527542
105Estrogen signaling pathway_Homo sapiens_hsa049150.80500137
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80131616
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78559714
108Arginine and proline metabolism_Homo sapiens_hsa003300.78115658
109Insulin secretion_Homo sapiens_hsa049110.76947851
110Protein digestion and absorption_Homo sapiens_hsa049740.76447577
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76126496
112Thyroid cancer_Homo sapiens_hsa052160.75692254
113N-Glycan biosynthesis_Homo sapiens_hsa005100.75163367
114Phagosome_Homo sapiens_hsa041450.74689585
115Pentose phosphate pathway_Homo sapiens_hsa000300.74475164
116Melanoma_Homo sapiens_hsa052180.73875102
117Purine metabolism_Homo sapiens_hsa002300.73758833
118MicroRNAs in cancer_Homo sapiens_hsa052060.73661566
119Cholinergic synapse_Homo sapiens_hsa047250.72995153
120Calcium signaling pathway_Homo sapiens_hsa040200.72590477
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72296377
122ErbB signaling pathway_Homo sapiens_hsa040120.72057213
123cAMP signaling pathway_Homo sapiens_hsa040240.71519545
124Phenylalanine metabolism_Homo sapiens_hsa003600.71293962
125Galactose metabolism_Homo sapiens_hsa000520.70876319
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70706398
127PPAR signaling pathway_Homo sapiens_hsa033200.70486851
128Sulfur metabolism_Homo sapiens_hsa009200.69954176
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.69702333
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66974040
131Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66183671
132Cocaine addiction_Homo sapiens_hsa050300.64468837
133Ras signaling pathway_Homo sapiens_hsa040140.64108256
134Prion diseases_Homo sapiens_hsa050200.63992100
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63685216
136Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62978572
137Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62557113
138Tryptophan metabolism_Homo sapiens_hsa003800.62312649
139Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62081854
140Glutathione metabolism_Homo sapiens_hsa004800.61785773
141Lysine degradation_Homo sapiens_hsa003100.59504829
142Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59118837
143Steroid hormone biosynthesis_Homo sapiens_hsa001400.58227143
144Dorso-ventral axis formation_Homo sapiens_hsa043200.57903763
145Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56797761
146Fatty acid metabolism_Homo sapiens_hsa012120.55234293
147Wnt signaling pathway_Homo sapiens_hsa043100.55213079
148Fatty acid degradation_Homo sapiens_hsa000710.53880420
149Ovarian steroidogenesis_Homo sapiens_hsa049130.53066173
150Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52700560
151Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52049602
152Tyrosine metabolism_Homo sapiens_hsa003500.52009774
153Sulfur relay system_Homo sapiens_hsa041220.52004594
1542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49631568
155Butanoate metabolism_Homo sapiens_hsa006500.49049636
156Retinol metabolism_Homo sapiens_hsa008300.46107166
157Pyruvate metabolism_Homo sapiens_hsa006200.45721422
158Leukocyte transendothelial migration_Homo sapiens_hsa046700.45554997
159Rheumatoid arthritis_Homo sapiens_hsa053230.45053768
160Circadian rhythm_Homo sapiens_hsa047100.44992085
161Pathways in cancer_Homo sapiens_hsa052000.43819759
162Metabolic pathways_Homo sapiens_hsa011000.42836321
163Shigellosis_Homo sapiens_hsa051310.38070248
164Huntingtons disease_Homo sapiens_hsa050160.34810225

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