PLSCR4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of neurotransmitter secretion (GO:0046929)7.23703085
2positive regulation of catecholamine secretion (GO:0033605)7.10318262
3positive regulation of amino acid transport (GO:0051957)6.69685003
4muscle organ morphogenesis (GO:0048644)6.64083041
5negative regulation of amino acid transport (GO:0051956)6.33512518
6definitive hemopoiesis (GO:0060216)5.82438070
7blood vessel maturation (GO:0001955)5.59887458
8platelet dense granule organization (GO:0060155)5.49992685
9mannose metabolic process (GO:0006013)5.38575283
10negative regulation of T-helper cell differentiation (GO:0045623)5.25875068
11negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)5.25875068
12negative regulation of neurotransmitter transport (GO:0051589)4.94483143
13* phospholipid scrambling (GO:0017121)4.91941518
14negative regulation of nitric oxide biosynthetic process (GO:0045019)4.57896458
15negative regulation of erythrocyte differentiation (GO:0045647)4.57175215
16regulation of glutamate secretion (GO:0014048)4.50381414
17negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.46673658
18serotonin receptor signaling pathway (GO:0007210)4.35357411
19negative regulation of organic acid transport (GO:0032891)4.28579015
20valine metabolic process (GO:0006573)4.23956091
21pharyngeal system development (GO:0060037)4.23767256
22positive regulation of natural killer cell differentiation (GO:0032825)4.09354092
23phenol-containing compound catabolic process (GO:0019336)4.01853511
24phagocytosis, recognition (GO:0006910)3.93251535
25response to mercury ion (GO:0046689)3.88201772
26sphingomyelin metabolic process (GO:0006684)3.87590094
27positive regulation of respiratory burst (GO:0060267)3.77601308
28CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.76754338
29positive regulation of gamma-delta T cell activation (GO:0046645)3.73979278
30keratan sulfate catabolic process (GO:0042340)3.72920027
31negative regulation of activin receptor signaling pathway (GO:0032926)3.71028801
32pathway-restricted SMAD protein phosphorylation (GO:0060389)3.69721547
33smooth muscle tissue development (GO:0048745)3.68866885
34positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.67046887
35N-glycan processing (GO:0006491)3.64681164
36motile cilium assembly (GO:0044458)3.63278635
37coronary vasculature morphogenesis (GO:0060977)3.60799469
38muscle cell fate commitment (GO:0042693)3.55243259
39epithelial cell fate commitment (GO:0072148)3.54410681
40cytokine production involved in immune response (GO:0002367)3.52576804
41negative regulation of protein tyrosine kinase activity (GO:0061099)3.52121925
42purine-containing compound salvage (GO:0043101)3.51826799
43antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.51181202
44positive regulation of vasoconstriction (GO:0045907)3.48986424
45regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.46927126
46negative regulation of alpha-beta T cell differentiation (GO:0046639)3.44374611
47secretory granule organization (GO:0033363)3.43035361
48actin filament capping (GO:0051693)3.41639995
49ovulation from ovarian follicle (GO:0001542)3.40823265
50protein targeting to plasma membrane (GO:0072661)3.39748365
51regulation of dopamine secretion (GO:0014059)3.39270813
52regulation of chemokine biosynthetic process (GO:0045073)3.35890648
53regulation of natural killer cell differentiation (GO:0032823)3.30195553
54antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.28960189
55antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.28960189
56regulation of amino acid transport (GO:0051955)3.28649956
57lymphangiogenesis (GO:0001946)3.27902421
58negative regulation of nitric-oxide synthase activity (GO:0051001)3.13332633
59lymph vessel development (GO:0001945)3.12578123
60retina vasculature morphogenesis in camera-type eye (GO:0061299)3.12247705
61phagocytosis, engulfment (GO:0006911)3.10727776
62response to interferon-alpha (GO:0035455)3.10094623
63vascular endothelial growth factor signaling pathway (GO:0038084)3.08547236
64norepinephrine metabolic process (GO:0042415)3.07194091
65peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.03847610
66positive regulation of amine transport (GO:0051954)3.03571575
67endothelial cell morphogenesis (GO:0001886)3.03351365
68protein heterotrimerization (GO:0070208)3.02322181
69venous blood vessel morphogenesis (GO:0048845)2.98448087
70regulation of type B pancreatic cell apoptotic process (GO:2000674)2.98129129
71response to interferon-beta (GO:0035456)2.98073266
72atrial septum morphogenesis (GO:0060413)2.95863342
73response to follicle-stimulating hormone (GO:0032354)2.95733549
74intestinal epithelial cell development (GO:0060576)2.94553979
75regulation of plasminogen activation (GO:0010755)2.94432890
76angiogenesis involved in wound healing (GO:0060055)2.89580902
77extracellular fibril organization (GO:0043206)2.89235893
78endosome to melanosome transport (GO:0035646)2.89203114
79endosome to pigment granule transport (GO:0043485)2.89203114
80negative regulation of actin filament depolymerization (GO:0030835)2.89184144
81positive regulation of organic acid transport (GO:0032892)2.89051880
82Peyers patch development (GO:0048541)2.87552842
83mucosal-associated lymphoid tissue development (GO:0048537)2.87552842
84ethanol oxidation (GO:0006069)2.87476901
85purine nucleotide salvage (GO:0032261)2.86654296
86lipid translocation (GO:0034204)2.82233387
87phospholipid translocation (GO:0045332)2.82233387
88detection of molecule of bacterial origin (GO:0032490)2.81807839
89negative regulation of stress fiber assembly (GO:0051497)2.79919493
90facial nerve structural organization (GO:0021612)2.77037521
91branched-chain amino acid catabolic process (GO:0009083)2.76997777
92negative regulation of complement activation (GO:0045916)2.76761878
93negative regulation of amine transport (GO:0051953)2.73219553
94regulation of gamma-delta T cell differentiation (GO:0045586)2.73087510
95regulation of gamma-delta T cell activation (GO:0046643)2.72903595
96heparin biosynthetic process (GO:0030210)2.72466960
97heparin metabolic process (GO:0030202)2.72466960
98positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.72209846
99extracellular matrix assembly (GO:0085029)2.70899298
100mature B cell differentiation involved in immune response (GO:0002313)2.69931444
101regulation of steroid hormone biosynthetic process (GO:0090030)2.69902681
102early endosome to late endosome transport (GO:0045022)2.69833067
103negative regulation of protein activation cascade (GO:2000258)2.68918361
104negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.68791003
105negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.68629325
106collagen fibril organization (GO:0030199)2.68278974
107cell migration involved in heart development (GO:0060973)2.68208725
108replacement ossification (GO:0036075)2.67344819
109endochondral ossification (GO:0001958)2.67344819
110regulation of cardioblast proliferation (GO:0003264)2.67142349
111regulation of secondary heart field cardioblast proliferation (GO:0003266)2.67142349
112sequestering of extracellular ligand from receptor (GO:0035581)2.66979071
113regulation of integrin-mediated signaling pathway (GO:2001044)2.63243009
114negative regulation of fibrinolysis (GO:0051918)2.61941413
115negative regulation of actin filament bundle assembly (GO:0032232)2.61220714
116chondrocyte proliferation (GO:0035988)2.60317546
117negative regulation of acute inflammatory response (GO:0002674)2.60139729
118response to protozoan (GO:0001562)2.58096670
119glomerular basement membrane development (GO:0032836)2.57982306
120negative regulation of chondrocyte differentiation (GO:0032331)2.57830912
121production of molecular mediator of immune response (GO:0002440)2.56516855
122histamine secretion (GO:0001821)2.56468508
123gland morphogenesis (GO:0022612)2.56463683
124vesicle fusion (GO:0006906)2.56403899
125sympathetic nervous system development (GO:0048485)2.56368779
126regulation of complement activation (GO:0030449)2.55646777
127regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.55436400
128histamine transport (GO:0051608)2.54845940
129antigen processing and presentation of endogenous antigen (GO:0019883)2.53326431
130lung morphogenesis (GO:0060425)2.53105795
131regulation of protein activation cascade (GO:2000257)2.50342099
132tooth mineralization (GO:0034505)2.49992055
133tonic smooth muscle contraction (GO:0014820)2.48869177
134membrane invagination (GO:0010324)2.48192113
135positive regulation of activated T cell proliferation (GO:0042104)2.47697414
136regulation of MHC class II biosynthetic process (GO:0045346)2.47052835
137outer ear morphogenesis (GO:0042473)2.46991440
138regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.46718568
139activin receptor signaling pathway (GO:0032924)2.45561350
140negative regulation of monooxygenase activity (GO:0032769)2.45309377
141positive regulation of vasculogenesis (GO:2001214)2.44781679
142glomerular filtration (GO:0003094)2.44682438
143endothelium development (GO:0003158)2.44460220
144behavioral response to nicotine (GO:0035095)2.44383345
145negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.43697498
146lung lobe morphogenesis (GO:0060463)2.41797036
147positive regulation of osteoblast proliferation (GO:0033690)2.40730423
148regulation of fibrinolysis (GO:0051917)2.40587937
149auditory receptor cell stereocilium organization (GO:0060088)2.40256278
150regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.40164552
151artery smooth muscle contraction (GO:0014824)2.39829946
152fibril organization (GO:0097435)2.39471000
153regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.38124057
154positive regulation of chemokine biosynthetic process (GO:0045080)2.37945067
155sprouting angiogenesis (GO:0002040)2.37382397
156negative regulation of platelet activation (GO:0010544)2.37179299
157mesenchymal-epithelial cell signaling (GO:0060638)2.36730175
158T cell lineage commitment (GO:0002360)2.35929086
159regulation of chronic inflammatory response (GO:0002676)2.34874775
160negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.34327067
161negative regulation of endothelial cell proliferation (GO:0001937)2.33652415
162patterning of blood vessels (GO:0001569)2.32763404
163regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.32372640
164cell proliferation involved in metanephros development (GO:0072203)2.31070837
165negative regulation of blood circulation (GO:1903523)2.30889557
166regulation of gonadotropin secretion (GO:0032276)2.30238142
167branched-chain amino acid metabolic process (GO:0009081)2.30130758
168neuron projection extension involved in neuron projection guidance (GO:1902284)2.30123713
169axon extension involved in axon guidance (GO:0048846)2.30123713
170regulation of non-canonical Wnt signaling pathway (GO:2000050)2.29818693
171phenylpropanoid metabolic process (GO:0009698)2.29511568
172regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.28782903
173renal filtration (GO:0097205)2.28679160
174endodermal cell differentiation (GO:0035987)2.27631682
175artery development (GO:0060840)2.27395855
176long-term synaptic potentiation (GO:0060291)2.27267515
177regulation of actin filament depolymerization (GO:0030834)2.27091405
178negative regulation of gluconeogenesis (GO:0045721)2.25839937
179platelet-derived growth factor receptor signaling pathway (GO:0048008)2.24345654
180cell proliferation involved in kidney development (GO:0072111)2.23891049
181complement activation, alternative pathway (GO:0006957)2.23734900
182positive regulation of fibroblast migration (GO:0010763)2.18569335
183blood coagulation, intrinsic pathway (GO:0007597)2.18091194
184cellular glucuronidation (GO:0052695)2.16758431
185negative regulation of cartilage development (GO:0061037)2.16754330
186regulation of phospholipase A2 activity (GO:0032429)2.14076692
187regulation of female receptivity (GO:0045924)2.13384443
188wound healing, spreading of epidermal cells (GO:0035313)2.12706228
189ethanol metabolic process (GO:0006067)2.12048909
190vascular smooth muscle contraction (GO:0014829)2.10557348

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human4.58599321
2SCL_19346495_ChIP-Seq_HPC-7_Human4.02748545
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.72672645
4* GATA2_21666600_ChIP-Seq_HMVEC_Human3.66309314
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.28942440
6RARG_19884340_ChIP-ChIP_MEFs_Mouse3.06424508
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.05017766
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.99332914
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.89781391
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.76848689
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.66416911
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.37199466
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.26608109
14RUNX_20019798_ChIP-Seq_JUKART_Human2.23026438
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.16575769
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.13489195
17LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.06896529
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.02679367
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.98225658
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.97932938
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.94401698
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.87162761
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.84803673
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.83158692
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.80716412
26* CJUN_26792858_Chip-Seq_BT549_Human1.79553455
27EP300_21415370_ChIP-Seq_HL-1_Mouse1.70148719
28CLOCK_20551151_ChIP-Seq_293T_Human1.68615907
29GATA1_19941826_ChIP-Seq_K562_Human1.68584216
30TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.67369908
31SOX2_20726797_ChIP-Seq_SW620_Human1.65601450
32* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.65452054
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.61651748
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.61473235
35STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.60898224
36CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.60693851
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60209126
38GBX2_23144817_ChIP-Seq_PC3_Human1.57992663
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.57843967
40* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.55778775
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.55043210
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.52774827
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.52774827
44LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.51615459
45CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.51564291
46IGF1R_20145208_ChIP-Seq_DFB_Human1.50411630
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.48011572
48NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.47323662
49CDX2_20551321_ChIP-Seq_CACO-2_Human1.46488937
50GATA2_19941826_ChIP-Seq_K562_Human1.45787173
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45380765
52MYB_21317192_ChIP-Seq_ERMYB_Mouse1.45213603
53TP53_18474530_ChIP-ChIP_U2OS_Human1.44274220
54TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43496718
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41362043
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40114424
57* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38763478
58* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38705764
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38606463
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37763713
61IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.35875739
62* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.35663421
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.33160527
64SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32828863
65FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.32194396
66FOXO3_23340844_ChIP-Seq_DLD1_Human1.31717206
67* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30157932
68NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.29939521
69NRF2_20460467_ChIP-Seq_MEFs_Mouse1.29939521
70PPAR_26484153_Chip-Seq_NCI-H1993_Human1.29005160
71* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28654206
72BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28062718
73EGR1_23403033_ChIP-Seq_LIVER_Mouse1.27418640
74SPI1_23127762_ChIP-Seq_K562_Human1.24956023
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.23659835
76* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22871520
77ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22346344
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.21259942
79VDR_24787735_ChIP-Seq_THP-1_Human1.20113794
80* SMAD4_21799915_ChIP-Seq_A2780_Human1.19687445
81JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19064110
82SALL4_18804426_ChIP-ChIP_XEN_Mouse1.18444935
83SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.18172700
84P300_19829295_ChIP-Seq_ESCs_Human1.17511502
85SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.16432734
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15457703
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13900886
88FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13384723
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12958183
90PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12889067
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12213170
92VDR_24763502_ChIP-Seq_THP-1_Human1.11975202
93GATA1_19941827_ChIP-Seq_MEL_Mouse1.11943429
94CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.10911580
95FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.09502754
96JARID2_20064375_ChIP-Seq_MESCs_Mouse1.09279726
97FLI1_27457419_Chip-Seq_LIVER_Mouse1.09092679
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08909822
99RXR_22158963_ChIP-Seq_LIVER_Mouse1.08722104
100ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07452589
101WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07103268
102RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07087186
103TCF4_18268006_ChIP-ChIP_LS174T_Human1.06387000
104KDM2B_26808549_Chip-Seq_REH_Human1.04838814
105LXR_22158963_ChIP-Seq_LIVER_Mouse1.04637784
106P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04097524
107STAT4_19710469_ChIP-ChIP_TH1__Mouse1.03161536
108NANOG_18555785_Chip-Seq_ESCs_Mouse1.03102531
109PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02777205
110RNF2_27304074_Chip-Seq_ESCs_Mouse1.02775393
111NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02663171
112EZH2_27304074_Chip-Seq_ESCs_Mouse1.01858570
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00976952
114TP63_23658742_ChIP-Seq_EP156T_Human1.00813098
115WT1_19549856_ChIP-ChIP_CCG9911_Human1.00384847
116SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00123078
117NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.99842291
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99589466
119STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99024063
120PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98991420
121TBX20_22080862_ChIP-Seq_HEART_Mouse0.98867563
122TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98375989
123SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.97449342
124SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.97449342
125EED_16625203_ChIP-ChIP_MESCs_Mouse0.96987336
126BCAT_22108803_ChIP-Seq_LS180_Human0.96830016
127PIAS1_25552417_ChIP-Seq_VCAP_Human0.96810932
128FOXA2_19822575_ChIP-Seq_HepG2_Human0.94258909
129SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94099685
130SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93722102
131EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.93530556
132RING1B_27294783_Chip-Seq_ESCs_Mouse0.93169709
133PPARA_22158963_ChIP-Seq_LIVER_Mouse0.92778740
134TP53_16413492_ChIP-PET_HCT116_Human0.92720477
135NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92708908
136EZH2_27294783_Chip-Seq_NPCs_Mouse0.92466492
137FUS_26573619_Chip-Seq_HEK293_Human0.92351503
138GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92294268
139ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92286299
140TAF15_26573619_Chip-Seq_HEK293_Human0.91608968
141DROSHA_22980978_ChIP-Seq_HELA_Human0.90756223
142NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90592583
143SMAD3_21741376_ChIP-Seq_EPCs_Human0.90475775
144SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.90071751
145GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87862340
146JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87767094
147BRD4_25478319_ChIP-Seq_HGPS_Human0.87715519
148TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.87164978
149PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.86616947
150SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.86068040
151IRF8_27001747_Chip-Seq_BMDM_Mouse0.84492617
152FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.83946190
153AR_21572438_ChIP-Seq_LNCaP_Human0.83739594
154TBX20_22328084_ChIP-Seq_HEART_Mouse0.83158129

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system4.84343815
2MP0003724_increased_susceptibility_to4.21570152
3MP0008438_abnormal_cutaneous_collagen3.54875297
4MP0001879_abnormal_lymphatic_vessel3.39566755
5MP0005167_abnormal_blood-brain_barrier2.91737231
6MP0008961_abnormal_basal_metabolism2.87492182
7MP0004272_abnormal_basement_membrane2.77791673
8MP0005503_abnormal_tendon_morphology2.71829915
9MP0003279_aneurysm2.69431309
10MP0004147_increased_porphyrin_level2.53363492
11MP0004782_abnormal_surfactant_physiolog2.52112509
12MP0000013_abnormal_adipose_tissue2.43539977
13MP0003868_abnormal_feces_composition2.41644588
14MP0001348_abnormal_lacrimal_gland2.32412353
15MP0009379_abnormal_foot_pigmentation2.29447067
16MP0005275_abnormal_skin_tensile2.19564363
17MP0002332_abnormal_exercise_endurance2.05700866
18MP0001958_emphysema2.01557322
19MP0004484_altered_response_of1.88885746
20MP0001986_abnormal_taste_sensitivity1.84706987
21MP0001873_stomach_inflammation1.84112109
22MP0003283_abnormal_digestive_organ1.83178878
23MP0005464_abnormal_platelet_physiology1.80945058
24MP0003943_abnormal_hepatobiliary_system1.80868778
25MP0003828_pulmonary_edema1.71109780
26MP0002837_dystrophic_cardiac_calcinosis1.70595982
27MP0002234_abnormal_pharynx_morphology1.67059736
28MP0005595_abnormal_vascular_smooth1.64248790
29MP0009697_abnormal_copulation1.63019261
30MP0006054_spinal_hemorrhage1.62579955
31MP0004215_abnormal_myocardial_fiber1.62385457
32MP0000751_myopathy1.61078612
33MP0000343_altered_response_to1.59546164
34MP0005670_abnormal_white_adipose1.59363037
35MP0001853_heart_inflammation1.57866920
36MP0004808_abnormal_hematopoietic_stem1.49230628
37MP0005084_abnormal_gallbladder_morpholo1.49040502
38MP0000249_abnormal_blood_vessel1.48868378
39MP0005164_abnormal_response_to1.48419860
40MP0002822_catalepsy1.48262283
41MP0003566_abnormal_cell_adhesion1.48197895
42MP0005166_decreased_susceptibility_to1.40799934
43MP0009764_decreased_sensitivity_to1.38207145
44MP0009278_abnormal_bone_marrow1.37238618
45MP0005257_abnormal_intraocular_pressure1.36511019
46MP0010386_abnormal_urinary_bladder1.36470426
47MP0005508_abnormal_skeleton_morphology1.36302098
48MP0006138_congestive_heart_failure1.36271827
49MP0003950_abnormal_plasma_membrane1.31542075
50MP0000465_gastrointestinal_hemorrhage1.29842913
51MP0004510_myositis1.27099818
52MP0003705_abnormal_hypodermis_morpholog1.25175335
53MP0002933_joint_inflammation1.24223526
54MP0009384_cardiac_valve_regurgitation1.22349490
55MP0008004_abnormal_stomach_pH1.21399267
56MP0001835_abnormal_antigen_presentation1.20950323
57MP0005397_hematopoietic_system_phenotyp1.20100815
58MP0001545_abnormal_hematopoietic_system1.20100815
59MP0000163_abnormal_cartilage_morphology1.16941547
60MP0000049_abnormal_middle_ear1.16808185
61MP0005023_abnormal_wound_healing1.16193240
62MP0009250_abnormal_appendicular_skeleto1.16177478
63MP0000613_abnormal_salivary_gland1.16056474
64MP0000767_abnormal_smooth_muscle1.15462160
65MP0002254_reproductive_system_inflammat1.14807626
66MP0000749_muscle_degeneration1.12757663
67MP0003191_abnormal_cellular_cholesterol1.12243122
68MP0004883_abnormal_blood_vessel1.11636438
69MP0001542_abnormal_bone_strength1.09182420
70MP0005330_cardiomyopathy1.08661801
71MP0002128_abnormal_blood_circulation1.08204736
72MP0001533_abnormal_skeleton_physiology1.07482704
73MP0005310_abnormal_salivary_gland1.05789780
74MP0008775_abnormal_heart_ventricle1.05398755
75MP0003045_fibrosis1.04604955
76MP0010329_abnormal_lipoprotein_level1.01874831
77MP0001270_distended_abdomen1.01369472
78MP0003091_abnormal_cell_migration1.01328239
79MP0005365_abnormal_bile_salt1.01123343
80MP0009785_altered_susceptibility_to1.00245927
81MP0002139_abnormal_hepatobiliary_system0.99786645
82MP0005385_cardiovascular_system_phenoty0.99394810
83MP0001544_abnormal_cardiovascular_syste0.99394810
84MP0000534_abnormal_ureter_morphology0.98877956
85MP0005623_abnormal_meninges_morphology0.97824340
86MP0002295_abnormal_pulmonary_circulatio0.97393996
87MP0002896_abnormal_bone_mineralization0.95555490
88MP0002108_abnormal_muscle_morphology0.95273962
89MP0005165_increased_susceptibility_to0.95124153
90MP0000003_abnormal_adipose_tissue0.94352122
91MP0002971_abnormal_brown_adipose0.93242131
92MP0000920_abnormal_myelination0.92923690
93MP0003186_abnormal_redox_activity0.92292844
94MP0001666_abnormal_nutrient_absorption0.90689746
95MP0003011_delayed_dark_adaptation0.90646785
96MP0005388_respiratory_system_phenotype0.90027455
97MP0005375_adipose_tissue_phenotype0.89281849
98MP0001664_abnormal_digestion0.87751161
99MP0002249_abnormal_larynx_morphology0.87618499
100MP0005409_darkened_coat_color0.86971120
101MP0002166_altered_tumor_susceptibility0.86764945
102MP0000230_abnormal_systemic_arterial0.85888539
103MP0004084_abnormal_cardiac_muscle0.85206649
104MP0002060_abnormal_skin_morphology0.84475653
105MP0005085_abnormal_gallbladder_physiolo0.83739250
106MP0000678_abnormal_parathyroid_gland0.82544077
107MP0005666_abnormal_adipose_tissue0.82049276
108MP0005620_abnormal_muscle_contractility0.81612479
109MP0000681_abnormal_thyroid_gland0.81558651
110MP0003252_abnormal_bile_duct0.80834435
111MP0010630_abnormal_cardiac_muscle0.80519662
112MP0005075_abnormal_melanosome_morpholog0.79084128
113MP0001851_eye_inflammation0.79009034
114MP0000462_abnormal_digestive_system0.78952828
115MP0002115_abnormal_skeleton_extremities0.78746374
116MP0005387_immune_system_phenotype0.78026942
117MP0001790_abnormal_immune_system0.78026942
118MP0006082_CNS_inflammation0.77330873
119MP0001661_extended_life_span0.76842495
120MP0009765_abnormal_xenobiotic_induced0.75649655
121MP0002127_abnormal_cardiovascular_syste0.75555482
122MP0002168_other_aberrant_phenotype0.75128665
123MP0005390_skeleton_phenotype0.74397174
124MP0003638_abnormal_response/metabolism_0.73811140
125MP0004130_abnormal_muscle_cell0.73764636
126MP0010030_abnormal_orbit_morphology0.72766682
127MP0008875_abnormal_xenobiotic_pharmacok0.72643717
128MP0001614_abnormal_blood_vessel0.72455399
129MP0009780_abnormal_chondrocyte_physiolo0.72286904
130MP0000372_irregular_coat_pigmentation0.71657558
131MP0008469_abnormal_protein_level0.71618595
132MP0005025_abnormal_response_to0.70635337
133MP0002419_abnormal_innate_immunity0.69497812
134MP0002876_abnormal_thyroid_physiology0.69228865
135MP0003935_abnormal_craniofacial_develop0.69170474
136MP0003941_abnormal_skin_development0.69040561
137MP0003634_abnormal_glial_cell0.68711046
138MP0002009_preneoplasia0.68255070
139MP0000762_abnormal_tongue_morphology0.68141579
140MP0010155_abnormal_intestine_physiology0.67802603
141MP0003633_abnormal_nervous_system0.67136471
142MP0002136_abnormal_kidney_physiology0.66598103
143MP0002396_abnormal_hematopoietic_system0.64611305
144MP0003656_abnormal_erythrocyte_physiolo0.64404956
145MP0001915_intracranial_hemorrhage0.62925766
146MP0002925_abnormal_cardiovascular_devel0.62543968
147MP0002133_abnormal_respiratory_system0.62489745

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the intrinsic pathway (HP:0010989)5.13336687
2Abnormality of the nasal mucosa (HP:0000433)4.72128166
3Absent/shortened dynein arms (HP:0200106)4.57835566
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.57835566
5Arterial tortuosity (HP:0005116)4.44243199
6Cervical subluxation (HP:0003308)4.21301557
7Nasal polyposis (HP:0100582)4.19143133
8Abnormality of the common coagulation pathway (HP:0010990)4.05877507
9Hypothermia (HP:0002045)3.98705557
10Beaking of vertebral bodies (HP:0004568)3.73498021
11Neonatal hypoglycemia (HP:0001998)3.72986408
12Complement deficiency (HP:0004431)3.72137187
13Cerebral aneurysm (HP:0004944)3.72126776
14Short 1st metacarpal (HP:0010034)3.55383592
15Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.55383592
16Metaphyseal dysplasia (HP:0100255)3.32525761
17Striae distensae (HP:0001065)3.31172700
18Cupped ribs (HP:0000887)3.26700825
19Vacuolated lymphocytes (HP:0001922)3.20373204
20Prolonged bleeding time (HP:0003010)3.18499840
21Soft skin (HP:0000977)3.18065005
22Growth hormone excess (HP:0000845)3.17080590
23Abnormality of the 1st metacarpal (HP:0010009)3.14670038
24Ovoid vertebral bodies (HP:0003300)3.12384367
25Scanning speech (HP:0002168)3.06053798
26Short hallux (HP:0010109)3.05311396
27Abnormality of complement system (HP:0005339)3.03514390
28Broad metatarsal (HP:0001783)2.98543043
29Mitral stenosis (HP:0001718)2.97128277
30Impaired platelet aggregation (HP:0003540)2.96450250
31Abnormal platelet function (HP:0011869)2.96450250
32Ragged-red muscle fibers (HP:0003200)2.92046742
33Abnormality of the renal collecting system (HP:0004742)2.79917597
34Vitreoretinal degeneration (HP:0000655)2.79367847
35Dilatation of the ascending aorta (HP:0005111)2.76637183
36Asymmetric septal hypertrophy (HP:0001670)2.76482530
37Aplasia/Hypoplasia of the hallux (HP:0008362)2.72502768
38Protrusio acetabuli (HP:0003179)2.71761712
39Aortic aneurysm (HP:0004942)2.67990674
40Overgrowth (HP:0001548)2.67411233
41Mesangial abnormality (HP:0001966)2.61640972
42Ulnar deviation of the wrist (HP:0003049)2.61203571
43Spinal rigidity (HP:0003306)2.56374704
44Abnormal ciliary motility (HP:0012262)2.54976325
45Congenital, generalized hypertrichosis (HP:0004540)2.52938146
46Vertebral hypoplasia (HP:0008417)2.52820880
47Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.52820880
48Increased variability in muscle fiber diameter (HP:0003557)2.49840140
49Hematochezia (HP:0002573)2.48184795
50Thrombocytosis (HP:0001894)2.43297116
51Mitral valve prolapse (HP:0001634)2.40488730
52Epiphyseal dysplasia (HP:0002656)2.40229784
53Vertebral arch anomaly (HP:0008438)2.39001927
54Fused cervical vertebrae (HP:0002949)2.38333447
55Enlarged penis (HP:0000040)2.38194280
56Cardiovascular calcification (HP:0011915)2.37746555
57Wrist flexion contracture (HP:0001239)2.35534135
58Neonatal short-limb short stature (HP:0008921)2.33779115
59Aortic valve stenosis (HP:0001650)2.31287743
60Aortic dissection (HP:0002647)2.30020751
61Vascular tortuosity (HP:0004948)2.27502670
62Spontaneous hematomas (HP:0007420)2.27329248
63Shallow orbits (HP:0000586)2.25946482
64Pulmonary artery stenosis (HP:0004415)2.25798480
65Atrophic scars (HP:0001075)2.25341720
66Short phalanx of the thumb (HP:0009660)2.24650122
67Abnormal respiratory epithelium morphology (HP:0012253)2.23430519
68Abnormal respiratory motile cilium morphology (HP:0005938)2.23430519
69Patchy hypopigmentation of hair (HP:0011365)2.21842057
70Abnormality of aromatic amino acid family metabolism (HP:0004338)2.21828939
71Adactyly (HP:0009776)2.21481161
72Systemic lupus erythematosus (HP:0002725)2.19845461
73Arterial thrombosis (HP:0004420)2.17917573
74Peritonitis (HP:0002586)2.17288378
75Stenosis of the external auditory canal (HP:0000402)2.17054269
76Bladder diverticulum (HP:0000015)2.16829116
77Portal hypertension (HP:0001409)2.16388762
78Round ear (HP:0100830)2.16382907
79Epistaxis (HP:0000421)2.14841765
80Joint stiffness (HP:0001387)2.14835702
81Bruising susceptibility (HP:0000978)2.14782653
82Abnormality of dental color (HP:0011073)2.14283558
83Polycythemia (HP:0001901)2.14136336
84Aneurysm (HP:0002617)2.13657998
85Blue sclerae (HP:0000592)2.12296736
86Autoimmune thrombocytopenia (HP:0001973)2.12293404
87Abnormality of the phalanges of the 2nd finger (HP:0009541)2.11347510
88Hypoplastic ischia (HP:0003175)2.10867846
89Ankle contracture (HP:0006466)2.09685975
90Aortic regurgitation (HP:0001659)2.07613178
91Esophageal varix (HP:0002040)2.06892341
92Accelerated skeletal maturation (HP:0005616)2.06029809
93Myoglobinuria (HP:0002913)2.05837837
94Vertebral compression fractures (HP:0002953)2.03278139
95Glomerulonephritis (HP:0000099)2.03227406
96Wormian bones (HP:0002645)2.02798136
97Lipoatrophy (HP:0100578)2.02267069
98Ectopia lentis (HP:0001083)2.01065323
99Coxa vara (HP:0002812)2.00505485
100Progressive muscle weakness (HP:0003323)1.98857880
101Ketosis (HP:0001946)1.98831528
102Type 1 muscle fiber predominance (HP:0003803)1.98198018
103Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.97936696
104Gingival bleeding (HP:0000225)1.97814964
105Nonprogressive disorder (HP:0003680)1.97211674
106Deep venous thrombosis (HP:0002625)1.96944550
107White forelock (HP:0002211)1.96554899
108Fragile skin (HP:0001030)1.95562042
109Petechiae (HP:0000967)1.95559262
110Abnormality of the hepatic vasculature (HP:0006707)1.93159614
111Abnormality of skeletal muscle fiber size (HP:0012084)1.93098402
112Hypercortisolism (HP:0001578)1.92835029
113J-shaped sella turcica (HP:0002680)1.92480358
114Flared iliac wings (HP:0002869)1.92189138
115Thoracolumbar scoliosis (HP:0002944)1.90068496
116Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.89213422
117Atrioventricular block (HP:0001678)1.88485974
118Joint hemorrhage (HP:0005261)1.88337471
119Flat acetabular roof (HP:0003180)1.87951802
120Mucopolysacchariduria (HP:0008155)1.87686910
121Urinary glycosaminoglycan excretion (HP:0003541)1.87686910
122Nephritis (HP:0000123)1.87616499
123Pancreatitis (HP:0001733)1.85306611
124Hyperlipoproteinemia (HP:0010980)1.84975917
125Polar cataract (HP:0010696)1.84122629
126Follicular hyperkeratosis (HP:0007502)1.83226951
127Limited hip movement (HP:0008800)1.82824051
128Spondylolisthesis (HP:0003302)1.82777833
129Irregular epiphyses (HP:0010582)1.82634819
130Amelogenesis imperfecta (HP:0000705)1.82416227
131Myotonia (HP:0002486)1.82403477
132Abnormality of skull ossification (HP:0002703)1.82093317
133Respiratory distress (HP:0002098)1.81908064
134Hyperpituitarism (HP:0010514)1.80025305
135Purpura (HP:0000979)1.79670275
136Spontaneous abortion (HP:0005268)1.79537654
137Joint laxity (HP:0001388)1.78448920
138Nonimmune hydrops fetalis (HP:0001790)1.78277318
139Keratoconus (HP:0000563)1.78264177
140Increased corneal curvature (HP:0100692)1.78264177
141Abnormality of the acetabulum (HP:0003170)1.77492338
142Abnormal tarsal ossification (HP:0008369)1.77380767
143Premature rupture of membranes (HP:0001788)1.77197917
144Vascular calcification (HP:0004934)1.76846342
145Muscle fiber splitting (HP:0003555)1.76747644
146Camptodactyly of toe (HP:0001836)1.76591796
147Glossoptosis (HP:0000162)1.76390144
148Mildly elevated creatine phosphokinase (HP:0008180)1.75833569
149Abnormality of the ischium (HP:0003174)1.73767093
150Abnormality of glycosaminoglycan metabolism (HP:0004371)1.73577014
151Abnormality of mucopolysaccharide metabolism (HP:0011020)1.73577014
152Abnormality of polysaccharide metabolism (HP:0011012)1.73577014
153Atrial fibrillation (HP:0005110)1.73527703
154Hyperextensible skin (HP:0000974)1.72961533
155Abnormality of the heme biosynthetic pathway (HP:0010472)1.72889455
156Prominent supraorbital ridges (HP:0000336)1.72888546
157Genu recurvatum (HP:0002816)1.72841626
158Venous insufficiency (HP:0005293)1.72303851
159Abnormality of dentin (HP:0010299)1.72231277
160Myositis (HP:0100614)1.71978947
161Menorrhagia (HP:0000132)1.70711804
162Xanthomatosis (HP:0000991)1.69749998
163Wide anterior fontanel (HP:0000260)1.69464076
164Hypoplasia of the iris (HP:0007676)1.69355849
165Coronal craniosynostosis (HP:0004440)1.68626536
166Action tremor (HP:0002345)1.68440902
167Hydroxyprolinuria (HP:0003080)1.68184636
168Biconcave vertebral bodies (HP:0004586)1.67893303
169Easy fatigability (HP:0003388)1.67134922

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.38495135
2EIF2AK34.85550492
3INSRR3.47841964
4CCNB13.05494647
5TGFBR23.03998244
6MUSK2.93408061
7MAP3K122.64584169
8MYLK2.50890944
9NME22.42901263
10BCKDK2.18299084
11PDK22.02298874
12PINK11.92116221
13TGFBR11.85991370
14MAP3K31.70740760
15IRAK31.69938859
16PDGFRA1.66530794
17TEC1.63924153
18DDR21.59836155
19FRK1.55873193
20KDR1.53875354
21RIPK11.49296748
22STK241.45048626
23TRPM71.44684963
24STK381.42291341
25BTK1.40898262
26MST1R1.39553205
27JAK31.32896146
28NTRK11.30220449
29KIT1.28746483
30FER1.28149989
31MAPK71.27600800
32IRAK41.22367298
33MAPKAPK51.21367494
34MATK1.20470003
35TBK11.19007032
36GRK71.17512436
37NLK1.16050680
38NEK91.15897771
39FGFR31.14979612
40MAPK121.12751957
41EPHA31.08689833
42MAPK41.06757424
43MKNK21.06297399
44PTK21.06230364
45GRK11.04707329
46CAMKK21.03069946
47IKBKB1.02807744
48MKNK11.01523960
49IKBKE0.95831790
50PTK2B0.95371923
51STK390.94909093
52PRKG20.94562667
53MAP2K20.94198543
54TTN0.91773955
55CHUK0.90464411
56FGFR40.89282178
57LATS20.88816759
58NEK60.87179728
59MET0.86630840
60EIF2AK20.86343444
61CAMK1D0.86300632
62MAP2K70.85871544
63PIK3CA0.85778967
64EEF2K0.84846899
65TXK0.82012663
66FGFR20.80754210
67IRAK10.79931021
68DMPK0.78585436
69PIK3CG0.77701775
70EPHB10.77099947
71LRRK20.76110469
72LATS10.75829676
73PIM20.75281013
74MAP4K10.74552453
75GRK50.73124067
76PAK20.73105123
77ERN10.70267087
78NTRK30.70234148
79CDK90.69897647
80PRKD20.68789326
81AKT30.68308932
82PTK60.67308190
83SGK20.65614737
84ABL20.63675039
85PAK40.63407255
86ERBB20.63220452
87MAPKAPK30.63055825
88PRKCH0.62625993
89ILK0.62068343
90SIK10.60667850
91MAPK150.60474785
92MAP3K60.58516850
93ERBB40.58233167
94MAP2K30.58043108
95ROCK10.58021021
96IGF1R0.57438135
97PDGFRB0.57078165
98ACVR1B0.57021281
99TNIK0.56684572
100SYK0.55211377
101PKN20.55171936
102CSF1R0.54939797
103PDK10.54039075
104PIM10.53883640
105INSR0.52968544
106WNK40.51882524
107JAK10.51065905
108BMX0.48895225
109NUAK10.47926593
110DAPK20.47545133
111FES0.47418459
112PRKAA20.46727570
113ERBB30.46496190
114RPS6KA20.46422154
115CDK190.46184482
116MAP2K10.46159450
117HIPK20.45032574
118PRKCE0.43831652
119CAMK10.43514853
120CAMK40.43448619
121PDPK10.43248239
122SGK30.43231703
123EPHB20.42889564
124STK38L0.42795535
125RPS6KA60.42386267
126MAPK30.42260139
127TRIB30.42245198
128PRKD10.41664624
129MAPK90.41561640
130SGK4940.41279691
131SGK2230.41279691
132RPS6KA50.40388123
133CDC42BPA0.39617202
134PAK60.39439492
135CAMK2G0.39038778
136TAF10.39025082
137CAMK1G0.38614879
138GSK3A0.37334269
139CDK80.37268801
140CSNK1G10.37260479
141LCK0.36714294
142BRSK20.35807957
143DAPK30.35706145
144AKT20.35443939
145BMPR1B0.35351570
146ROCK20.35216050
147FGFR10.34226445
148CAMK2D0.32298892
149LMTK20.31649638
150WNK10.30640603
151PHKG10.29787283
152PHKG20.29787283
153STK30.29742445
154MAP3K20.29117592
155ZAP700.28679277
156RET0.27670282
157CAMK2B0.27622265
158ADRBK10.27443469
159PRKG10.25475618
160NTRK20.23646316
161SRC0.23190663
162MAP2K60.22926116

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.16441410
2Other glycan degradation_Homo sapiens_hsa005113.15882171
3Sulfur relay system_Homo sapiens_hsa041223.05315236
4Sphingolipid metabolism_Homo sapiens_hsa006002.78188345
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.56723319
6ECM-receptor interaction_Homo sapiens_hsa045122.46865444
7Vitamin digestion and absorption_Homo sapiens_hsa049772.35600694
8Asthma_Homo sapiens_hsa053102.01977744
9Ovarian steroidogenesis_Homo sapiens_hsa049131.79415378
10Platelet activation_Homo sapiens_hsa046111.77546918
11AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.72314307
12Leishmaniasis_Homo sapiens_hsa051401.69459402
13Caffeine metabolism_Homo sapiens_hsa002321.65010078
14Protein digestion and absorption_Homo sapiens_hsa049741.64664509
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.64659309
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.57430931
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.57096753
18Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.55723840
19Allograft rejection_Homo sapiens_hsa053301.54536604
20SNARE interactions in vesicular transport_Homo sapiens_hsa041301.53235123
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.51344447
22Focal adhesion_Homo sapiens_hsa045101.46838325
23Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.44130649
24Renin-angiotensin system_Homo sapiens_hsa046141.40915101
25Sulfur metabolism_Homo sapiens_hsa009201.40599086
26ABC transporters_Homo sapiens_hsa020101.40582732
27Hematopoietic cell lineage_Homo sapiens_hsa046401.39504447
28Malaria_Homo sapiens_hsa051441.39225772
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37666671
30Complement and coagulation cascades_Homo sapiens_hsa046101.37628974
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.36027928
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.33836543
33Fatty acid degradation_Homo sapiens_hsa000711.32992852
34PPAR signaling pathway_Homo sapiens_hsa033201.29769146
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.26800105
36Mineral absorption_Homo sapiens_hsa049781.24347187
37African trypanosomiasis_Homo sapiens_hsa051431.22941985
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.18596088
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16395876
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.15357447
41Serotonergic synapse_Homo sapiens_hsa047261.14485358
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.11748129
43Vitamin B6 metabolism_Homo sapiens_hsa007501.10396042
44Bile secretion_Homo sapiens_hsa049761.09672166
45Salivary secretion_Homo sapiens_hsa049701.09419107
46Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.08798166
47TGF-beta signaling pathway_Homo sapiens_hsa043501.07515952
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06194828
49Propanoate metabolism_Homo sapiens_hsa006401.05767589
50PI3K-Akt signaling pathway_Homo sapiens_hsa041511.04203459
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.00706612
52Galactose metabolism_Homo sapiens_hsa000521.00555984
53Amoebiasis_Homo sapiens_hsa051461.00159769
54cAMP signaling pathway_Homo sapiens_hsa040240.97717546
55Tryptophan metabolism_Homo sapiens_hsa003800.97544377
56Dilated cardiomyopathy_Homo sapiens_hsa054140.95841165
57Pertussis_Homo sapiens_hsa051330.91850716
58N-Glycan biosynthesis_Homo sapiens_hsa005100.91667892
59Prion diseases_Homo sapiens_hsa050200.90655434
60Insulin secretion_Homo sapiens_hsa049110.89955783
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89582855
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88662097
63Osteoclast differentiation_Homo sapiens_hsa043800.87523887
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87414357
65Prolactin signaling pathway_Homo sapiens_hsa049170.86640515
66Autoimmune thyroid disease_Homo sapiens_hsa053200.86221169
67Tyrosine metabolism_Homo sapiens_hsa003500.85644844
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85299419
69Measles_Homo sapiens_hsa051620.83712555
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.83324719
71Histidine metabolism_Homo sapiens_hsa003400.81879502
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79890103
73Gap junction_Homo sapiens_hsa045400.79599565
74Ribosome_Homo sapiens_hsa030100.79577148
75B cell receptor signaling pathway_Homo sapiens_hsa046620.79019742
76Starch and sucrose metabolism_Homo sapiens_hsa005000.78014209
77Arginine biosynthesis_Homo sapiens_hsa002200.77898887
78TNF signaling pathway_Homo sapiens_hsa046680.77728845
79Insulin signaling pathway_Homo sapiens_hsa049100.76063609
80beta-Alanine metabolism_Homo sapiens_hsa004100.75384894
81Salmonella infection_Homo sapiens_hsa051320.73535969
82Rap1 signaling pathway_Homo sapiens_hsa040150.72013323
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71908119
84Rheumatoid arthritis_Homo sapiens_hsa053230.71780698
85Toxoplasmosis_Homo sapiens_hsa051450.71539747
86Staphylococcus aureus infection_Homo sapiens_hsa051500.71136744
87Insulin resistance_Homo sapiens_hsa049310.68590436
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68193691
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68111950
90Hedgehog signaling pathway_Homo sapiens_hsa043400.67727475
91Gastric acid secretion_Homo sapiens_hsa049710.67297474
92Circadian rhythm_Homo sapiens_hsa047100.67198886
93Circadian entrainment_Homo sapiens_hsa047130.66360353
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.65620653
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64213340
96Pancreatic secretion_Homo sapiens_hsa049720.63360336
97Fat digestion and absorption_Homo sapiens_hsa049750.62160853
98HIF-1 signaling pathway_Homo sapiens_hsa040660.61603778
99Renin secretion_Homo sapiens_hsa049240.59865313
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.58600360
101Linoleic acid metabolism_Homo sapiens_hsa005910.57405668
102Butanoate metabolism_Homo sapiens_hsa006500.57123761
103Adherens junction_Homo sapiens_hsa045200.56681312
104Legionellosis_Homo sapiens_hsa051340.56638341
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55214394
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53573196
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.53551664
108Arachidonic acid metabolism_Homo sapiens_hsa005900.52086526
109Fatty acid elongation_Homo sapiens_hsa000620.51770778
110Thyroid hormone synthesis_Homo sapiens_hsa049180.51696383
111Glutamatergic synapse_Homo sapiens_hsa047240.51680846
112Folate biosynthesis_Homo sapiens_hsa007900.51640830
113Retinol metabolism_Homo sapiens_hsa008300.51370493
114Fatty acid metabolism_Homo sapiens_hsa012120.51168785
115Phenylalanine metabolism_Homo sapiens_hsa003600.48682467
116Arginine and proline metabolism_Homo sapiens_hsa003300.48418328
117Chemical carcinogenesis_Homo sapiens_hsa052040.48268530
118Morphine addiction_Homo sapiens_hsa050320.47982015
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.47720536
120Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47538229
121Cocaine addiction_Homo sapiens_hsa050300.47514377
122Basal cell carcinoma_Homo sapiens_hsa052170.46664081
123Melanoma_Homo sapiens_hsa052180.46664060
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45795864
125Toll-like receptor signaling pathway_Homo sapiens_hsa046200.45627892
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44509958
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.43950843
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43515456
129Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43102782
130Proteoglycans in cancer_Homo sapiens_hsa052050.42728771
131Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42187849
132Tight junction_Homo sapiens_hsa045300.41503765
133GABAergic synapse_Homo sapiens_hsa047270.41324927
134alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41266170
135Amphetamine addiction_Homo sapiens_hsa050310.40425540
136NF-kappa B signaling pathway_Homo sapiens_hsa040640.40277656
137Glucagon signaling pathway_Homo sapiens_hsa049220.40220056
138Ras signaling pathway_Homo sapiens_hsa040140.40158969
139Melanogenesis_Homo sapiens_hsa049160.39834515
140Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37292518
141Calcium signaling pathway_Homo sapiens_hsa040200.36261219
142Shigellosis_Homo sapiens_hsa051310.35929143
143Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34916562
144Acute myeloid leukemia_Homo sapiens_hsa052210.34413412
145Peroxisome_Homo sapiens_hsa041460.33728307
146Pathways in cancer_Homo sapiens_hsa052000.33393604
147Wnt signaling pathway_Homo sapiens_hsa043100.31426965

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