PLSCR5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sphingosine metabolic process (GO:0006670)9.01144758
2diol metabolic process (GO:0034311)7.98340287
3regulation of odontogenesis of dentin-containing tooth (GO:0042487)7.32972107
4sphingoid metabolic process (GO:0046519)7.25142183
5protein-chromophore linkage (GO:0018298)5.61285591
6regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.32146859
7epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)5.28914464
8regulation of meiosis I (GO:0060631)5.25773454
9negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.24696295
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.18778754
11regulation of dendritic cell antigen processing and presentation (GO:0002604)5.08674110
12paraxial mesoderm development (GO:0048339)5.01997728
13regulation of pigment cell differentiation (GO:0050932)4.99005511
14positive regulation of meiosis (GO:0045836)4.93409207
15DNA methylation involved in gamete generation (GO:0043046)4.92424948
16regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.88509201
17regulation of relaxation of muscle (GO:1901077)4.87651290
18negative regulation of potassium ion transmembrane transport (GO:1901380)4.85353695
19notochord development (GO:0030903)4.84261063
20regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.76663381
21bundle of His cell to Purkinje myocyte communication (GO:0086069)4.73163086
22regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.62946881
23cell communication involved in cardiac conduction (GO:0086065)4.55790342
24positive regulation of meiotic cell cycle (GO:0051446)4.55452388
25respiratory electron transport chain (GO:0022904)4.54286720
26regulation of cell communication by electrical coupling (GO:0010649)4.49904289
27regulation of transforming growth factor beta2 production (GO:0032909)4.49886470
28electron transport chain (GO:0022900)4.44096229
29positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.42333157
30lipopolysaccharide biosynthetic process (GO:0009103)4.37473306
31mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.37092351
32ventricular cardiac muscle cell action potential (GO:0086005)4.35382238
33vitamin transmembrane transport (GO:0035461)4.34984960
34positive regulation of developmental pigmentation (GO:0048087)4.33489335
35ATP synthesis coupled proton transport (GO:0015986)4.31247069
36energy coupled proton transport, down electrochemical gradient (GO:0015985)4.31247069
37sarcomere organization (GO:0045214)4.26539411
38sympathetic nervous system development (GO:0048485)4.25731220
39sulfate transmembrane transport (GO:1902358)4.25040236
40interferon-gamma secretion (GO:0072643)4.24465353
41positive regulation of Cdc42 GTPase activity (GO:0043089)4.24023718
42SMAD protein complex assembly (GO:0007183)4.23956737
43regulation of hair follicle development (GO:0051797)4.21990208
44gamma-aminobutyric acid signaling pathway (GO:0007214)4.20213461
45oxygen transport (GO:0015671)4.19549875
46neurotransmitter catabolic process (GO:0042135)4.16503059
47L-phenylalanine catabolic process (GO:0006559)4.12312743
48erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.12312743
49growth hormone secretion (GO:0030252)4.12031701
50cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.11171324
51cardiac myofibril assembly (GO:0055003)4.09449383
52tricarboxylic acid cycle (GO:0006099)4.08073429
53regulation of odontogenesis (GO:0042481)4.00347915
54regulation of actin filament-based movement (GO:1903115)3.97434237
55genitalia morphogenesis (GO:0035112)3.94980337
56ribonucleoprotein complex disassembly (GO:0032988)3.93323239
57cardiac muscle contraction (GO:0060048)3.90062107
58regulation of protein glycosylation (GO:0060049)3.89149152
59mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.86828435
60regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.86354515
61sarcoplasmic reticulum calcium ion transport (GO:0070296)3.85050557
62neurotransmitter biosynthetic process (GO:0042136)3.83607402
63cardiac muscle cell development (GO:0055013)3.82676838
64serotonin receptor signaling pathway (GO:0007210)3.81480648
65negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.73945219
66regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.71922393
67sulfate transport (GO:0008272)3.71740958
68ventricular cardiac muscle cell development (GO:0055015)3.68975457
69embryonic skeletal joint morphogenesis (GO:0060272)3.68412992
70calcium-mediated signaling using intracellular calcium source (GO:0035584)3.64151650
71myofibril assembly (GO:0030239)3.64065467
72piRNA metabolic process (GO:0034587)3.63710182
73negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.61417131
74cardiac cell development (GO:0055006)3.59452439
75regulation of membrane repolarization (GO:0060306)3.58102497
76regulation of cardiac muscle cell contraction (GO:0086004)3.56113513
77lipopolysaccharide metabolic process (GO:0008653)3.54313149
78cell communication by electrical coupling (GO:0010644)3.51523772
79meiotic chromosome segregation (GO:0045132)3.50778808
80mesenchymal cell proliferation (GO:0010463)3.50476749
81relaxation of cardiac muscle (GO:0055119)3.50259292
82ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.45949153
83uterus development (GO:0060065)3.45018710
84lateral sprouting from an epithelium (GO:0060601)3.44996626
85negative regulation of striated muscle cell apoptotic process (GO:0010664)3.43712242
86creatine metabolic process (GO:0006600)3.42604597
87pancreas development (GO:0031016)3.41920395
88organelle disassembly (GO:1903008)3.38844840
89nodal signaling pathway (GO:0038092)3.37712291
90positive regulation of SMAD protein import into nucleus (GO:0060391)3.37179283
91regulation of T-helper 1 cell differentiation (GO:0045625)3.37140633
92cardiac muscle tissue morphogenesis (GO:0055008)3.35787554
93striated muscle atrophy (GO:0014891)3.34410201
94negative regulation of muscle hypertrophy (GO:0014741)3.31844038
95L-phenylalanine metabolic process (GO:0006558)3.30560039
96erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.30560039
97gastrulation with mouth forming second (GO:0001702)3.28392444
98organ formation (GO:0048645)3.26633081
99tyrosine metabolic process (GO:0006570)3.25284926
100positive regulation of catecholamine secretion (GO:0033605)3.22540871
101regulation of keratinocyte proliferation (GO:0010837)3.22167093
102establishment of nucleus localization (GO:0040023)3.21243934
103positive regulation of granulocyte chemotaxis (GO:0071624)3.21168211
104carnitine shuttle (GO:0006853)3.19247285
105positive regulation of growth hormone secretion (GO:0060124)3.18414896
106regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.18327818
107succinate metabolic process (GO:0006105)3.17961167
108negative regulation of stem cell proliferation (GO:2000647)3.16967155
109regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.16921847
110regulation of heart rate by cardiac conduction (GO:0086091)3.15746023
111plasma membrane repair (GO:0001778)3.15487938
112organ induction (GO:0001759)3.14741050
113somite rostral/caudal axis specification (GO:0032525)3.13083496
114oxidative phosphorylation (GO:0006119)3.12992853
115generation of neurons (GO:0048699)3.12692253
116regulation of striated muscle contraction (GO:0006942)3.12563004
117regulation of cardiac muscle contraction (GO:0055117)3.12483770
118regulation of hair cycle (GO:0042634)3.11438067
119synaptic transmission, cholinergic (GO:0007271)3.11146811
120short-term memory (GO:0007614)3.10917180
121regulation of mesenchymal cell apoptotic process (GO:2001053)3.10903413
122positive regulation of uterine smooth muscle contraction (GO:0070474)3.08280133
123keratinocyte development (GO:0003334)3.08219156
124regulation of calcium ion transmembrane transport (GO:1903169)3.07482216
125regulation of calcium ion transmembrane transporter activity (GO:1901019)3.07482216
126negative regulation of transcription regulatory region DNA binding (GO:2000678)3.07109298
127cardiac conduction (GO:0061337)3.06856584
128positive regulation of antigen processing and presentation (GO:0002579)3.05888286
129centriole replication (GO:0007099)3.05463996
130aromatic amino acid family catabolic process (GO:0009074)3.04426742
131detection of calcium ion (GO:0005513)3.04066723
132membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.03058364
133cardiac muscle cell action potential involved in contraction (GO:0086002)3.00909723
134cartilage morphogenesis (GO:0060536)3.00389644
135negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.98626163
136muscle atrophy (GO:0014889)2.98195368
137regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.97778293
138response to nitric oxide (GO:0071731)2.97438681
139cardiac muscle cell action potential (GO:0086001)2.96425313
140regulation of activin receptor signaling pathway (GO:0032925)2.96343815
141skeletal muscle adaptation (GO:0043501)2.94423807
142muscle tissue morphogenesis (GO:0060415)2.94014261
143embryonic foregut morphogenesis (GO:0048617)2.93584442
144negative regulation of cell cycle G2/M phase transition (GO:1902750)2.92232964
145ATP biosynthetic process (GO:0006754)2.91092941
146heart trabecula formation (GO:0060347)2.90765213
147heart process (GO:0003015)2.89944580
148heart contraction (GO:0060047)2.89944580
149cellular ketone body metabolic process (GO:0046950)2.89920594
1502-oxoglutarate metabolic process (GO:0006103)2.89583594
151regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.88441123
152striated muscle contraction (GO:0006941)2.87543453
153fatty acid transmembrane transport (GO:1902001)2.87052438
154negative regulation of calcium ion transmembrane transport (GO:1903170)2.86288613
155negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.86288613
156negative regulation of BMP signaling pathway (GO:0030514)2.85914215
157branch elongation of an epithelium (GO:0060602)2.85566724
158nitric oxide biosynthetic process (GO:0006809)2.85403151
159neurofilament cytoskeleton organization (GO:0060052)2.85346368
160peristalsis (GO:0030432)2.83561016
161galactose catabolic process (GO:0019388)2.83553291
162postsynaptic membrane organization (GO:0001941)2.82631664
163negative regulation of keratinocyte proliferation (GO:0010839)2.82049305
164hair follicle morphogenesis (GO:0031069)2.81564954
165regulation of the force of heart contraction (GO:0002026)2.80937290
166regulation of heart rate (GO:0002027)2.80577629
167positive regulation of dendritic spine morphogenesis (GO:0061003)2.80476047
168SMAD protein signal transduction (GO:0060395)2.80236795
169positive regulation of T-helper 1 type immune response (GO:0002827)2.78775725
170galactose metabolic process (GO:0006012)2.77389824
171regulation of BMP signaling pathway (GO:0030510)2.76929283
172response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.76657237
173neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.76624326
174regulation of acyl-CoA biosynthetic process (GO:0050812)2.76530672
175behavioral response to nicotine (GO:0035095)2.75089444
176cell migration in hindbrain (GO:0021535)2.74522832
177cardiac epithelial to mesenchymal transition (GO:0060317)2.74179193
178fatty acid homeostasis (GO:0055089)2.72530044
179positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.70028528
180morphogenesis of an epithelial fold (GO:0060571)2.67465738
181cytidine metabolic process (GO:0046087)2.66970204
182cytidine catabolic process (GO:0006216)2.66970204
183cytidine deamination (GO:0009972)2.66970204
184response to prostaglandin E (GO:0034695)2.66002837
185synaptic vesicle maturation (GO:0016188)2.65408473
186retinal ganglion cell axon guidance (GO:0031290)2.65156884
187regulation of interleukin-5 production (GO:0032674)2.64245864
188cellular response to epinephrine stimulus (GO:0071872)2.64131996
189kidney morphogenesis (GO:0060993)2.64007725
190neurotransmitter metabolic process (GO:0042133)2.63035737
191alkaloid metabolic process (GO:0009820)2.62775169
192regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.62636864
193mesenchymal cell differentiation (GO:0048762)2.62215151
194positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.62180328
195regulation of SMAD protein import into nucleus (GO:0060390)2.61953081
196regulation of heart morphogenesis (GO:2000826)2.58641566
197tachykinin receptor signaling pathway (GO:0007217)2.58526672

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.61539156
2IGF1R_20145208_ChIP-Seq_DFB_Human3.37743319
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.07593777
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.84447602
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.82960778
6EZH2_22144423_ChIP-Seq_EOC_Human2.81615186
7ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.70969259
8EP300_21415370_ChIP-Seq_HL-1_Mouse2.69619171
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.63729777
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.45579657
11DROSHA_22980978_ChIP-Seq_HELA_Human2.43847193
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.34960111
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.31817375
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.13121578
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.07559484
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.05853645
17CDX2_19796622_ChIP-Seq_MESCs_Mouse2.04871896
18ESR1_20079471_ChIP-ChIP_T-47D_Human2.04232126
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.01024612
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.99607534
21EZH2_18974828_ChIP-Seq_MESCs_Mouse1.98632453
22RNF2_18974828_ChIP-Seq_MESCs_Mouse1.98632453
23MTF2_20144788_ChIP-Seq_MESCs_Mouse1.90737231
24NR3C1_23031785_ChIP-Seq_PC12_Mouse1.88077057
25EWS_26573619_Chip-Seq_HEK293_Human1.87389037
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82190568
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78555943
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.77067665
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76517246
30CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.76486878
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74863465
32TBX20_22328084_ChIP-Seq_HEART_Mouse1.74641217
33TBX20_22080862_ChIP-Seq_HEART_Mouse1.74641217
34FUS_26573619_Chip-Seq_HEK293_Human1.74002805
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.66875953
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.64178678
37TAF15_26573619_Chip-Seq_HEK293_Human1.59529384
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59173823
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.58832230
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.57928152
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57163492
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57047558
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.55895955
44BCAT_22108803_ChIP-Seq_LS180_Human1.55825937
45TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53891516
46POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.53891516
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53457306
48GBX2_23144817_ChIP-Seq_PC3_Human1.52660387
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.50966356
50TP53_18474530_ChIP-ChIP_U2OS_Human1.48515962
51PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.48482982
52ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.47380152
53NANOG_19829295_ChIP-Seq_ESCs_Human1.45601246
54SOX2_19829295_ChIP-Seq_ESCs_Human1.45601246
55TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42663929
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41078253
57VDR_22108803_ChIP-Seq_LS180_Human1.40436997
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.39313534
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.38588765
60SUZ12_27294783_Chip-Seq_ESCs_Mouse1.38585892
61ER_23166858_ChIP-Seq_MCF-7_Human1.38017828
62RNF2_27304074_Chip-Seq_NSC_Mouse1.34478958
63EED_16625203_ChIP-ChIP_MESCs_Mouse1.33542011
64TBX3_20139965_ChIP-Seq_MESCs_Mouse1.31039150
65CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.30890510
66TBX3_20139965_ChIP-Seq_ESCs_Mouse1.30515253
67TAL1_26923725_Chip-Seq_HPCs_Mouse1.30156678
68BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28782971
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.26959872
70FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.25546554
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25097239
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24418342
73TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.22577003
74TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21804624
75VDR_24787735_ChIP-Seq_THP-1_Human1.21662665
76TCF4_23295773_ChIP-Seq_U87_Human1.21462749
77AR_21572438_ChIP-Seq_LNCaP_Human1.21412526
78FOXO3_23340844_ChIP-Seq_DLD1_Human1.20369276
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20074704
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20027001
81MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19640763
82AR_25329375_ChIP-Seq_VCAP_Human1.19524585
83SMAD4_21799915_ChIP-Seq_A2780_Human1.19349885
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.16903848
85RXR_22158963_ChIP-Seq_LIVER_Mouse1.16682373
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.15965714
87SOX2_21211035_ChIP-Seq_LN229_Gbm1.15644729
88TCF4_22108803_ChIP-Seq_LS180_Human1.15542785
89RNF2_27304074_Chip-Seq_ESCs_Mouse1.15322856
90SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.15181244
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15096143
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14482603
93POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14427106
94NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13668789
95ZNF274_21170338_ChIP-Seq_K562_Hela1.13117137
96FLI1_21867929_ChIP-Seq_TH2_Mouse1.13025165
97LXR_22158963_ChIP-Seq_LIVER_Mouse1.12296912
98P300_19829295_ChIP-Seq_ESCs_Human1.11722153
99CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11576250
100WT1_19549856_ChIP-ChIP_CCG9911_Human1.10748842
101CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10703862
102STAT3_18555785_ChIP-Seq_MESCs_Mouse1.10319690
103WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09559112
104SMAD4_21741376_ChIP-Seq_EPCs_Human1.09374479
105TCF4_18268006_ChIP-ChIP_LS174T_Human1.09369580
106PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08483822
107RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08072767
108EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07935862
109* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07584171
110KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06633310
111TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05481257
112NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05282362
113NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05282362
114ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04337422
115FOXA2_19822575_ChIP-Seq_HepG2_Human1.02217194
116REST_21632747_ChIP-Seq_MESCs_Mouse1.01966986
117AR_19668381_ChIP-Seq_PC3_Human1.01440974
118TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01027998
119ISL1_27105846_Chip-Seq_CPCs_Mouse1.00798425
120PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00394824
121NANOG_18555785_Chip-Seq_ESCs_Mouse1.00198402
122SMAD3_21741376_ChIP-Seq_ESCs_Human0.99754835
123RUNX2_22187159_ChIP-Seq_PCA_Human0.99619072
124* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99425845
125TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99020634
126TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98354694
127MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97790953
128KDM2B_26808549_Chip-Seq_REH_Human0.97286235
129CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96820902
130PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.96628656
131ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94217830
132OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93787128
133CTCF_27219007_Chip-Seq_Bcells_Human0.92973755
134GATA1_22025678_ChIP-Seq_K562_Human0.92675579
135TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91769558
136CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90902393
137MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90724453
138REST_18959480_ChIP-ChIP_MESCs_Mouse0.89531412
139SMAD3_21741376_ChIP-Seq_HESCs_Human0.89084785
140ARNT_22903824_ChIP-Seq_MCF-7_Human0.88956168
141* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88885475
142POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88306623
143FLI1_27457419_Chip-Seq_LIVER_Mouse0.88093955
144FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87557409
145BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86783363
146SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86488405
147* STAT3_23295773_ChIP-Seq_U87_Human0.86469891
148RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.86081493
149PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86030457
150CTBP2_25329375_ChIP-Seq_LNCAP_Human0.85770858
151SMAD4_21741376_ChIP-Seq_HESCs_Human0.85100216
152UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84672704
153AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84410085

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color6.18059025
2MP0003890_abnormal_embryonic-extraembry4.84459497
3MP0002837_dystrophic_cardiac_calcinosis4.79039665
4MP0005171_absent_coat_pigmentation4.61235833
5MP0004084_abnormal_cardiac_muscle3.74177212
6MP0000751_myopathy3.68723575
7MP0006054_spinal_hemorrhage3.63079426
8MP0004215_abnormal_myocardial_fiber3.58996628
9MP0002254_reproductive_system_inflammat3.49101460
10MP0003646_muscle_fatigue3.18398659
11MP0000537_abnormal_urethra_morphology3.15519287
12MP0004510_myositis3.10933492
13MP0002653_abnormal_ependyma_morphology3.07235895
14MP0005330_cardiomyopathy3.04228352
15MP0000749_muscle_degeneration3.00907600
16MP0001348_abnormal_lacrimal_gland2.96178619
17MP0003879_abnormal_hair_cell2.83672668
18MP0004036_abnormal_muscle_relaxation2.79720120
19MP0002938_white_spotting2.78336522
20MP0002972_abnormal_cardiac_muscle2.68578259
21MP0004484_altered_response_of2.59010228
22MP0002876_abnormal_thyroid_physiology2.38407846
23MP0001485_abnormal_pinna_reflex2.33446583
24MP0002735_abnormal_chemical_nociception2.22540739
25MP0003137_abnormal_impulse_conducting2.18603226
26MP0008775_abnormal_heart_ventricle2.14755023
27MP0001544_abnormal_cardiovascular_syste2.13204685
28MP0005385_cardiovascular_system_phenoty2.13204685
29MP0004270_analgesia2.09757741
30MP0004130_abnormal_muscle_cell2.09216971
31MP0001529_abnormal_vocalization2.07733914
32MP0001346_abnormal_lacrimal_gland2.04161948
33MP0004087_abnormal_muscle_fiber2.04009077
34MP0003937_abnormal_limbs/digits/tail_de2.01643325
35MP0000516_abnormal_urinary_system1.97698257
36MP0005367_renal/urinary_system_phenotyp1.97698257
37MP0003045_fibrosis1.96806798
38MP0002822_catalepsy1.96795566
39MP0005647_abnormal_sex_gland1.94159827
40MP0005187_abnormal_penis_morphology1.92237461
41MP0005620_abnormal_muscle_contractility1.88044459
42MP0003221_abnormal_cardiomyocyte_apopto1.87450936
43MP0002638_abnormal_pupillary_reflex1.85483432
44MP0004085_abnormal_heartbeat1.82877316
45MP0004147_increased_porphyrin_level1.81519905
46MP0001984_abnormal_olfaction1.79767328
47MP0006276_abnormal_autonomic_nervous1.76182813
48MP0003828_pulmonary_edema1.67709748
49MP0010630_abnormal_cardiac_muscle1.65288061
50MP0009250_abnormal_appendicular_skeleto1.63218412
51MP0004381_abnormal_hair_follicle1.61810396
52MP0005075_abnormal_melanosome_morpholog1.60096772
53MP0000685_abnormal_immune_system1.59911210
54MP0002269_muscular_atrophy1.56452838
55MP0002106_abnormal_muscle_physiology1.55844241
56MP0006036_abnormal_mitochondrial_physio1.55684756
57MP0001286_abnormal_eye_development1.55079532
58MP0003119_abnormal_digestive_system1.51529300
59MP0003941_abnormal_skin_development1.51233656
60MP0002102_abnormal_ear_morphology1.50451031
61MP0000534_abnormal_ureter_morphology1.50429992
62MP0006138_congestive_heart_failure1.47298705
63MP0003385_abnormal_body_wall1.46822730
64MP0003880_abnormal_central_pattern1.42475055
65MP0002697_abnormal_eye_size1.41681200
66MP0009053_abnormal_anal_canal1.39160374
67MP0003938_abnormal_ear_development1.38398288
68MP0002160_abnormal_reproductive_system1.31154772
69MP0000759_abnormal_skeletal_muscle1.29933687
70MP0005646_abnormal_pituitary_gland1.24510084
71MP0005365_abnormal_bile_salt1.24376314
72MP0005248_abnormal_Harderian_gland1.23694275
73MP0002909_abnormal_adrenal_gland1.22675154
74MP0000747_muscle_weakness1.22552185
75MP0003878_abnormal_ear_physiology1.21645315
76MP0005377_hearing/vestibular/ear_phenot1.21645315
77MP0005369_muscle_phenotype1.20825992
78MP0005085_abnormal_gallbladder_physiolo1.20666773
79MP0002734_abnormal_mechanical_nocicepti1.19408684
80MP0001324_abnormal_eye_pigmentation1.17979351
81MP0004859_abnormal_synaptic_plasticity1.17631179
82MP0000343_altered_response_to1.15985878
83MP0003183_abnormal_peptide_metabolism1.15502745
84MP0003942_abnormal_urinary_system1.14946113
85MP0000750_abnormal_muscle_regeneration1.14737159
86MP0002168_other_aberrant_phenotype1.13537875
87MP0000569_abnormal_digit_pigmentation1.11991245
88MP0002733_abnormal_thermal_nociception1.11831239
89MP0010352_gastrointestinal_tract_polyps1.09725481
90MP0003195_calcinosis1.09656646
91MP0004858_abnormal_nervous_system1.09174298
92MP0004145_abnormal_muscle_electrophysio1.07693103
93MP0005535_abnormal_body_temperature1.07186886
94MP0002272_abnormal_nervous_system1.07133624
95MP0005645_abnormal_hypothalamus_physiol1.06885256
96MP0003122_maternal_imprinting1.04567632
97MP0004742_abnormal_vestibular_system1.04187216
98MP0001963_abnormal_hearing_physiology1.02321175
99MP0003315_abnormal_perineum_morphology1.01656683
100MP0005165_increased_susceptibility_to0.99814395
101MP0002184_abnormal_innervation0.99446482
102MP0000778_abnormal_nervous_system0.99170264
103MP0002332_abnormal_exercise_endurance0.99030327
104MP0000427_abnormal_hair_cycle0.98071461
105MP0003959_abnormal_lean_body0.96318424
106MP0002127_abnormal_cardiovascular_syste0.93595295
107MP0000647_abnormal_sebaceous_gland0.93249404
108MP0001501_abnormal_sleep_pattern0.90098504
109MP0000383_abnormal_hair_follicle0.87605708
110MP0003943_abnormal_hepatobiliary_system0.86317540
111MP0005076_abnormal_cell_differentiation0.85739732
112MP0005332_abnormal_amino_acid0.84417572
113MP0002138_abnormal_hepatobiliary_system0.82798335
114MP0005220_abnormal_exocrine_pancreas0.82184439
115MP0001293_anophthalmia0.80749666
116MP0003935_abnormal_craniofacial_develop0.80584060
117MP0002282_abnormal_trachea_morphology0.80450995
118MP0005266_abnormal_metabolism0.80246703
119MP0002078_abnormal_glucose_homeostasis0.80231327
120MP0008874_decreased_physiological_sensi0.80174709
121MP0005623_abnormal_meninges_morphology0.80139474
122MP0000003_abnormal_adipose_tissue0.80015192
123MP0000432_abnormal_head_morphology0.79891592
124MP0002557_abnormal_social/conspecific_i0.79141382
125MP0000428_abnormal_craniofacial_morphol0.78383786
126MP0004885_abnormal_endolymph0.78147287
127MP0005551_abnormal_eye_electrophysiolog0.77254476
128MP0001440_abnormal_grooming_behavior0.77140140
129MP0002095_abnormal_skin_pigmentation0.76823453
130MP0002233_abnormal_nose_morphology0.76756131
131MP0009697_abnormal_copulation0.76231417
132MP0000049_abnormal_middle_ear0.75780435
133MP0001970_abnormal_pain_threshold0.75628489
134MP0000230_abnormal_systemic_arterial0.75048563
135MP0000026_abnormal_inner_ear0.74842591
136MP0006035_abnormal_mitochondrial_morpho0.73544519
137MP0002752_abnormal_somatic_nervous0.73377746
138MP0002928_abnormal_bile_duct0.72566596
139MP0009780_abnormal_chondrocyte_physiolo0.71676387
140MP0003121_genomic_imprinting0.71346401
141MP0010678_abnormal_skin_adnexa0.71153969
142MP0002108_abnormal_muscle_morphology0.70913688
143MP0001486_abnormal_startle_reflex0.70853773
144MP0002971_abnormal_brown_adipose0.70851776
145MP0005195_abnormal_posterior_eye0.70570401
146MP0000538_abnormal_urinary_bladder0.69863448
147MP0002084_abnormal_developmental_patter0.69685271
148MP0004142_abnormal_muscle_tone0.69508042
149MP0004043_abnormal_pH_regulation0.68566079
150MP0004924_abnormal_behavior0.68524434
151MP0005386_behavior/neurological_phenoty0.68524434
152MP0004133_heterotaxia0.66779645
153MP0003635_abnormal_synaptic_transmissio0.66388002
154MP0008569_lethality_at_weaning0.66319968
155MP0002118_abnormal_lipid_homeostasis0.65693666
156MP0005670_abnormal_white_adipose0.65507285
157MP0002229_neurodegeneration0.64484590
158MP0002111_abnormal_tail_morphology0.62608664
159MP0001299_abnormal_eye_distance/0.62247620
160MP0002751_abnormal_autonomic_nervous0.61968772
161MP0003806_abnormal_nucleotide_metabolis0.61805171
162MP0005310_abnormal_salivary_gland0.61757059
163MP0010030_abnormal_orbit_morphology0.61665308
164MP0006082_CNS_inflammation0.61282565
165MP0002067_abnormal_sensory_capabilities0.60614465
166MP0003861_abnormal_nervous_system0.60430405
167MP0000955_abnormal_spinal_cord0.60123987
168MP0005334_abnormal_fat_pad0.59945839
169MP0001873_stomach_inflammation0.59527438
170MP0010386_abnormal_urinary_bladder0.58991456
171MP0009745_abnormal_behavioral_response0.58958445
172MP0005395_other_phenotype0.58813855
173MP0002882_abnormal_neuron_morphology0.56994531
174MP0000462_abnormal_digestive_system0.56214986
175MP0003252_abnormal_bile_duct0.56130985
176MP0002572_abnormal_emotion/affect_behav0.56115248

Predicted human phenotypes

RankGene SetZ-score
1Ventricular tachycardia (HP:0004756)5.65041052
2Sudden death (HP:0001699)5.52906813
3Amelogenesis imperfecta (HP:0000705)5.33007481
4Acanthocytosis (HP:0001927)5.01242148
5Acute necrotizing encephalopathy (HP:0006965)5.01196707
6Abnormal mitochondria in muscle tissue (HP:0008316)4.95151979
7Morphological abnormality of the middle ear (HP:0008609)4.81894410
8Palpitations (HP:0001962)4.73413196
9Right ventricular cardiomyopathy (HP:0011663)4.64343305
10Atrial fibrillation (HP:0005110)4.61402804
11Bundle branch block (HP:0011710)4.52818352
12Acute encephalopathy (HP:0006846)4.48353467
13Progressive macrocephaly (HP:0004481)4.36465335
14Abnormality of the vocal cords (HP:0008777)4.33962940
15Primary atrial arrhythmia (HP:0001692)4.33638258
16Proximal tubulopathy (HP:0000114)4.29943262
17Supraventricular tachycardia (HP:0004755)4.14950780
18Congenital malformation of the right heart (HP:0011723)4.06556114
19Double outlet right ventricle (HP:0001719)4.06556114
20Cerebral edema (HP:0002181)4.04560997
21Supraventricular arrhythmia (HP:0005115)4.02717502
22Syncope (HP:0001279)4.01583488
23Disproportionate short-trunk short stature (HP:0003521)3.99512542
24Calf muscle hypertrophy (HP:0008981)3.98746157
25Pheochromocytoma (HP:0002666)3.82519572
26Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.80765442
27Volvulus (HP:0002580)3.74908746
28Lipoatrophy (HP:0100578)3.70512311
29Prolonged QT interval (HP:0001657)3.57240221
30Abnormality of the calf musculature (HP:0001430)3.53809883
31Muscle hypertrophy of the lower extremities (HP:0008968)3.53473796
32Neuroendocrine neoplasm (HP:0100634)3.46492315
33Mitochondrial inheritance (HP:0001427)3.46287713
34Enlarged kidneys (HP:0000105)3.44268540
35Hyporeflexia of lower limbs (HP:0002600)3.43024072
36Heart block (HP:0012722)3.38304555
37Hepatic necrosis (HP:0002605)3.33481937
38Exercise-induced myalgia (HP:0003738)3.29559554
39Myoglobinuria (HP:0002913)3.26080964
40Myelomeningocele (HP:0002475)3.23642253
41Abnormal atrioventricular conduction (HP:0005150)3.19104589
42Dilated cardiomyopathy (HP:0001644)3.17771320
43Muscle fiber splitting (HP:0003555)3.17342728
44Ventricular arrhythmia (HP:0004308)3.09237984
45Colon cancer (HP:0003003)3.06307966
46Exercise-induced muscle cramps (HP:0003710)3.03414086
47Increased CSF lactate (HP:0002490)3.02727782
48Asymmetric septal hypertrophy (HP:0001670)3.01990732
49Hypoglycemic coma (HP:0001325)3.01659213
50Rectal prolapse (HP:0002035)3.01566583
51Myokymia (HP:0002411)3.01517950
52Dialeptic seizures (HP:0011146)3.00096633
53Ketoacidosis (HP:0001993)2.98351118
54Abnormality of aromatic amino acid family metabolism (HP:0004338)2.98344106
55Cervical subluxation (HP:0003308)2.98166331
56Vertebral arch anomaly (HP:0008438)2.95221137
57Anophthalmia (HP:0000528)2.92917734
58Ventricular fibrillation (HP:0001663)2.89442724
59Proximal amyotrophy (HP:0007126)2.88264794
60Abnormality of the renal cortex (HP:0011035)2.88243584
61Hepatocellular necrosis (HP:0001404)2.86078237
62EMG: myopathic abnormalities (HP:0003458)2.82178655
63Pancreatic cysts (HP:0001737)2.80397952
64Bifid tongue (HP:0010297)2.79824839
65Cutaneous finger syndactyly (HP:0010554)2.78548183
66Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.72138028
67Aplasia/Hypoplasia of the uvula (HP:0010293)2.71967887
68Parakeratosis (HP:0001036)2.71594698
69Abnormality of fatty-acid metabolism (HP:0004359)2.69593221
70Aplasia/Hypoplasia of the sternum (HP:0006714)2.66810530
71Congenital ichthyosiform erythroderma (HP:0007431)2.66250344
72Respiratory failure (HP:0002878)2.65151956
73Bilateral microphthalmos (HP:0007633)2.65025357
74Intestinal atresia (HP:0011100)2.64849020
75Atrioventricular block (HP:0001678)2.59061555
76Abnormality of the renal medulla (HP:0100957)2.58963253
77Conjunctival hamartoma (HP:0100780)2.57821846
78Nephronophthisis (HP:0000090)2.57707928
79Myotonia (HP:0002486)2.52518682
80Abnormal tarsal ossification (HP:0008369)2.51962894
81Increased muscle lipid content (HP:0009058)2.51929977
82Exercise intolerance (HP:0003546)2.51608171
83Hypothermia (HP:0002045)2.50634627
84Hypercortisolism (HP:0001578)2.50442790
85Lactic acidosis (HP:0003128)2.46510104
86Synostosis of carpal bones (HP:0005048)2.44024385
87Difficulty walking (HP:0002355)2.42925491
88Focal seizures (HP:0007359)2.42395458
89Abnormality of the wing of the ilium (HP:0011867)2.42050056
90Long clavicles (HP:0000890)2.41991046
91Optic disc pallor (HP:0000543)2.39590641
92Proximal placement of thumb (HP:0009623)2.38293297
93Abnormality of dicarboxylic acid metabolism (HP:0010995)2.38254692
94Dicarboxylic aciduria (HP:0003215)2.38254692
95Hypoplastic iliac wings (HP:0002866)2.37211166
96Thyroid-stimulating hormone excess (HP:0002925)2.36983677
97High anterior hairline (HP:0009890)2.36845413
98Bicornuate uterus (HP:0000813)2.36228239
99Cortical dysplasia (HP:0002539)2.36012822
100Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.34759055
101Decreased activity of mitochondrial respiratory chain (HP:0008972)2.34759055
102Abnormal EKG (HP:0003115)2.32781041
103Left ventricular hypertrophy (HP:0001712)2.32354030
104Increased intramyocellular lipid droplets (HP:0012240)2.32262500
105Distal lower limb muscle weakness (HP:0009053)2.32146819
106Action tremor (HP:0002345)2.31488262
107Anencephaly (HP:0002323)2.30740824
108Abnormality of the pubic bones (HP:0003172)2.30738950
109Aplastic anemia (HP:0001915)2.30265639
110Cutaneous syndactyly (HP:0012725)2.27584705
111Ketosis (HP:0001946)2.26789504
112Abnormality of the ischium (HP:0003174)2.21999954
113Genital tract atresia (HP:0001827)2.19879272
114Short 1st metacarpal (HP:0010034)2.18500247
115Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.18500247
116Hyperglycemia (HP:0003074)2.18095898
117Foot dorsiflexor weakness (HP:0009027)2.17887479
118IgM deficiency (HP:0002850)2.17883031
119Asymmetry of the thorax (HP:0001555)2.17636247
1202-3 toe syndactyly (HP:0004691)2.16919571
121Hypoplasia of the odontoid process (HP:0003311)2.16446533
122Autoamputation (HP:0001218)2.14503661
123Hypoplastic ischia (HP:0003175)2.13384053
124Ulnar claw (HP:0001178)2.13339214
125Vaginal atresia (HP:0000148)2.11467004
126Deviation of the thumb (HP:0009603)2.11277407
127Steppage gait (HP:0003376)2.09684299
128Poikilocytosis (HP:0004447)2.08766627
129Esophageal varix (HP:0002040)2.08723997
130Leukodystrophy (HP:0002415)2.08214729
131Ulnar deviation of the wrist (HP:0003049)2.07884030
132Sudden cardiac death (HP:0001645)2.07869638
133Abnormality of monocarboxylic acid metabolism (HP:0010996)2.07005900
134Tubulointerstitial fibrosis (HP:0005576)2.06987909
135Lipid accumulation in hepatocytes (HP:0006561)2.06088930
136Keratoconjunctivitis (HP:0001096)2.05202013
137Hematochezia (HP:0002573)2.02018193
138Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.01628148
139Cerebral hemorrhage (HP:0001342)2.01047517
140Potter facies (HP:0002009)2.00396399
141Facial shape deformation (HP:0011334)2.00396399
142Rhabdomyolysis (HP:0003201)2.00375376
143Generalized myoclonic seizures (HP:0002123)2.00200036
144Tinnitus (HP:0000360)2.00112154
145Pancreatic islet-cell hyperplasia (HP:0004510)2.00014983
146Lethargy (HP:0001254)1.98981247
147Abnormality of the foot musculature (HP:0001436)1.98503139
148Severe Myopia (HP:0011003)1.98280227
149Renal cortical cysts (HP:0000803)1.97012067
150Palmoplantar keratoderma (HP:0000982)1.96830173
151Difficulty running (HP:0009046)1.95854582
152Generalized aminoaciduria (HP:0002909)1.95322052
153Renal hypoplasia (HP:0000089)1.94705203
154Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.94051520
155Xerostomia (HP:0000217)1.93530251
156Bell-shaped thorax (HP:0001591)1.92840324
157Subaortic stenosis (HP:0001682)1.89398954
158Abnormality of the left ventricular outflow tract (HP:0011103)1.89398954
159Abnormality of urine glucose concentration (HP:0011016)1.89392094
160Glycosuria (HP:0003076)1.89392094
161Neoplasm of the peripheral nervous system (HP:0100007)1.89354994
162Hyperammonemia (HP:0001987)1.89350476
163Areflexia of lower limbs (HP:0002522)1.89290431
164Abnormality of the 1st metacarpal (HP:0010009)1.88672247
165Long nose (HP:0003189)1.88631894
166Cupped ear (HP:0000378)1.88163859
167Hyperinsulinemic hypoglycemia (HP:0000825)1.86787097
168Vacuolated lymphocytes (HP:0001922)1.86010147
169Diastasis recti (HP:0001540)1.85951203
170Erythroderma (HP:0001019)1.85670266
171Abnormality of calcium-phosphate metabolism (HP:0100530)1.85462780
172Termporal pattern (HP:0011008)1.84304958
173Insidious onset (HP:0003587)1.84304958
174Cholelithiasis (HP:0001081)1.83297472
175Neoplasm of the adrenal gland (HP:0100631)1.83033591
176Onion bulb formation (HP:0003383)1.81974456
177Muscle stiffness (HP:0003552)1.79017638
178Absent eyebrow (HP:0002223)1.78943152
179Focal motor seizures (HP:0011153)1.78063604
180Aplasia/Hypoplasia of the tibia (HP:0005772)1.77227986
181Abnormal foot bone ossification (HP:0010675)1.76865851
182Tarsal synostosis (HP:0008368)1.74104542
183Abnormality of the nasal septum (HP:0000419)1.73656754
184Short phalanx of the thumb (HP:0009660)1.73206732
185Neoplasm of the small intestine (HP:0100833)1.72694912
186Abnormality of the middle phalanges of the toes (HP:0010183)1.70757387
187Tracheal stenosis (HP:0002777)1.70735258
188Hypoplasia of the capital femoral epiphysis (HP:0003090)1.68431792
189Small epiphyses (HP:0010585)1.67741201
190Gastrointestinal atresia (HP:0002589)1.64724042
191Synostosis involving bones of the feet (HP:0009140)1.64172194
192Synostosis involving bones of the lower limbs (HP:0009138)1.64172194
193Abnormality of the odontoid process (HP:0003310)1.63050754
194Cerebellar dysplasia (HP:0007033)1.61743597
195Scapular winging (HP:0003691)1.61622756

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS17.76181188
2TRIM285.02896974
3LMTK23.46128509
4TTN3.17320177
5ACVR1B2.99177048
6GRK72.89228818
7FRK2.82654809
8WNK42.75193583
9MUSK2.74037441
10STK392.69068098
11SIK32.67015294
12PHKG22.55206221
13PHKG12.55206221
14NTRK12.55186467
15EPHA32.54184511
16BCR2.46912939
17PDK42.46716242
18PDK32.46716242
19MYLK2.38572518
20BMPR1B2.36521106
21BCKDK2.12306996
22PLK42.06740024
23OBSCN1.98299946
24WNK11.93598109
25ZAK1.92220831
26EPHB11.81279109
27TGFBR11.77102007
28PINK11.75688734
29PRKD31.75413421
30TNIK1.74263353
31OXSR11.60164782
32NME21.54831136
33DDR21.52552698
34NTRK31.51186144
35INSRR1.49278013
36STK31.43998783
37MKNK21.38914384
38PAK31.35736379
39TRPM71.34277222
40EPHA41.34045172
41FGFR21.33880534
42FGFR41.31018541
43TAF11.29876116
44PKN21.27807484
45CAMK2D1.25904362
46NLK1.23181524
47SCYL21.21383323
48PDK21.20258373
49PIK3CG1.10924399
50GRK51.08705813
51MAP2K21.08587929
52PIK3CA1.06932912
53STK241.05692557
54CDC42BPA1.01659253
55NEK20.98779482
56DMPK0.97696803
57MAP3K140.95555459
58PRKCE0.95182870
59MINK10.93393454
60TLK10.92302123
61LRRK20.91943666
62MKNK10.88348222
63ERBB30.87382669
64CLK10.87287738
65CSNK1G30.82612728
66CAMK2G0.81434730
67WEE10.81351929
68CDK190.80303673
69JAK10.79858223
70CASK0.77826136
71CAMK2A0.77609911
72MAP4K20.75713868
73ROCK20.73561394
74MAP3K70.73515060
75PRKCQ0.72181983
76PKN10.71082184
77LATS20.70860126
78EIF2AK30.70821997
79DYRK1B0.69465378
80NEK90.69412252
81ROCK10.69394390
82KSR20.68307901
83IRAK40.68291367
84CSNK1G20.68251549
85NEK10.66523561
86UHMK10.66317345
87ITK0.64261004
88WNK30.64211937
89ADRBK10.63847205
90FLT30.63090729
91FGFR30.62416215
92CSNK1G10.62185262
93MAPKAPK50.61307794
94PRKD10.61298437
95JAK20.59180211
96TTK0.59134889
97PRKACB0.59039664
98STK38L0.58378652
99ERBB20.56950579
100SGK2230.56780649
101SGK4940.56780649
102LIMK10.56433124
103MAP2K10.55962882
104MAP3K20.55309299
105PRKAA20.55245088
106ADRBK20.54844700
107RET0.54739531
108MATK0.54502876
109TIE10.54123423
110TGFBR20.53107243
111PRKCI0.52448309
112PDPK10.52347289
113FER0.51582275
114PASK0.49836919
115STK110.49519354
116ARAF0.49368068
117MAP3K90.49357542
118PDK10.49136599
119MELK0.48350202
120PLK30.48113536
121CAMK10.47368973
122PRKACA0.47242979
123PAK60.46988490
124MAP2K70.46820010
125BMPR20.46675220
126MAP3K120.45857124
127MAP2K40.45695593
128PRKACG0.45350189
129CDK30.44194734
130CSNK1A1L0.43795045
131PRKCH0.43606195
132EPHB20.43217869
133STK380.42711825
134CDK50.40955102
135SGK20.40073115
136KSR10.39332485
137SYK0.38849909
138PLK10.37956224
139MAP3K40.37356704
140PRKCD0.36553794
141PRKCG0.35890260
142PLK20.35648564
143PRKAA10.35549729
144MAP3K60.33855047
145BRSK20.32442550
146ILK0.30421380
147CDK80.27203633
148MARK10.26191483
149SRPK10.26154034
150STK100.24176570
151NME10.24022862
152CSNK1D0.22911562
153PNCK0.19321293
154TEC0.12140798
155GRK10.12125886
156FGFR10.11310604
157AKT20.10530785
158PDGFRA0.10029840
159CHEK20.07429876
160ABL10.06119910

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.22462149
2Oxidative phosphorylation_Homo sapiens_hsa001903.93866394
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.72849078
4Parkinsons disease_Homo sapiens_hsa050123.72488600
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.58982341
6Phototransduction_Homo sapiens_hsa047443.48612441
7Cardiac muscle contraction_Homo sapiens_hsa042603.10078025
8Alzheimers disease_Homo sapiens_hsa050102.82971899
9Propanoate metabolism_Homo sapiens_hsa006402.75654991
10Sphingolipid metabolism_Homo sapiens_hsa006002.59652508
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.37132501
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.35934347
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.34544391
14Dilated cardiomyopathy_Homo sapiens_hsa054142.28935052
15Fatty acid degradation_Homo sapiens_hsa000712.27432393
16Huntingtons disease_Homo sapiens_hsa050162.22045775
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.19427692
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.19317897
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.18380823
20Arginine biosynthesis_Homo sapiens_hsa002202.11983560
21Basal cell carcinoma_Homo sapiens_hsa052172.02861977
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.01413504
23Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.00407333
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.92900086
25TGF-beta signaling pathway_Homo sapiens_hsa043501.78646817
26Vitamin digestion and absorption_Homo sapiens_hsa049771.78029149
27Fatty acid metabolism_Homo sapiens_hsa012121.77145257
28Hippo signaling pathway_Homo sapiens_hsa043901.76491574
29Sulfur metabolism_Homo sapiens_hsa009201.67775440
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.60603162
31N-Glycan biosynthesis_Homo sapiens_hsa005101.59118865
32Fatty acid elongation_Homo sapiens_hsa000621.57341829
33Butanoate metabolism_Homo sapiens_hsa006501.55240314
34Nitrogen metabolism_Homo sapiens_hsa009101.49239137
35Phenylalanine metabolism_Homo sapiens_hsa003601.49146339
36Pyruvate metabolism_Homo sapiens_hsa006201.45565078
37Hedgehog signaling pathway_Homo sapiens_hsa043401.42003618
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38289993
39Carbon metabolism_Homo sapiens_hsa012001.37475558
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29921948
41ECM-receptor interaction_Homo sapiens_hsa045121.26552036
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.25817189
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.25521812
44Histidine metabolism_Homo sapiens_hsa003401.23666296
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16448322
46Linoleic acid metabolism_Homo sapiens_hsa005911.13602379
47Basal transcription factors_Homo sapiens_hsa030221.12187048
48Wnt signaling pathway_Homo sapiens_hsa043101.12163682
49Tryptophan metabolism_Homo sapiens_hsa003801.10593023
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.08202697
51Tyrosine metabolism_Homo sapiens_hsa003501.04695614
52Melanogenesis_Homo sapiens_hsa049161.04658363
53Dorso-ventral axis formation_Homo sapiens_hsa043201.03385667
54Arginine and proline metabolism_Homo sapiens_hsa003301.02725790
55Adherens junction_Homo sapiens_hsa045201.01999552
56Thyroid hormone synthesis_Homo sapiens_hsa049180.99484394
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91957957
58Oocyte meiosis_Homo sapiens_hsa041140.89597221
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.88295715
60Axon guidance_Homo sapiens_hsa043600.87546942
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86194630
62Peroxisome_Homo sapiens_hsa041460.85308989
63PPAR signaling pathway_Homo sapiens_hsa033200.84758404
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.82991757
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.82777085
66Colorectal cancer_Homo sapiens_hsa052100.78768433
67Viral myocarditis_Homo sapiens_hsa054160.78748018
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76732699
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76076122
70Calcium signaling pathway_Homo sapiens_hsa040200.75851425
71Cholinergic synapse_Homo sapiens_hsa047250.75672724
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72096835
73Circadian entrainment_Homo sapiens_hsa047130.70030939
74Starch and sucrose metabolism_Homo sapiens_hsa005000.68970736
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67849868
76Complement and coagulation cascades_Homo sapiens_hsa046100.66465186
77One carbon pool by folate_Homo sapiens_hsa006700.66308705
78Olfactory transduction_Homo sapiens_hsa047400.63880932
79Retinol metabolism_Homo sapiens_hsa008300.63450090
80Fat digestion and absorption_Homo sapiens_hsa049750.62444561
81beta-Alanine metabolism_Homo sapiens_hsa004100.60681251
82Glucagon signaling pathway_Homo sapiens_hsa049220.60343495
83Insulin resistance_Homo sapiens_hsa049310.60166739
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57681822
85Bile secretion_Homo sapiens_hsa049760.56827494
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55655925
87Amphetamine addiction_Homo sapiens_hsa050310.53985977
88Steroid biosynthesis_Homo sapiens_hsa001000.53969946
89Gastric acid secretion_Homo sapiens_hsa049710.53765489
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53066376
91ABC transporters_Homo sapiens_hsa020100.52723975
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.52495594
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.51673023
94Insulin secretion_Homo sapiens_hsa049110.51584349
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51189148
96Renin secretion_Homo sapiens_hsa049240.51011818
97Salivary secretion_Homo sapiens_hsa049700.50400595
98Biosynthesis of amino acids_Homo sapiens_hsa012300.48668157
99Taste transduction_Homo sapiens_hsa047420.48468447
100Cell cycle_Homo sapiens_hsa041100.48376166
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48070581
102Ether lipid metabolism_Homo sapiens_hsa005650.47395471
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46706237
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46330627
105Dopaminergic synapse_Homo sapiens_hsa047280.45236574
106Insulin signaling pathway_Homo sapiens_hsa049100.44756178
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44275018
108Caffeine metabolism_Homo sapiens_hsa002320.44044447
109Oxytocin signaling pathway_Homo sapiens_hsa049210.43425982
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42409479
111Serotonergic synapse_Homo sapiens_hsa047260.42348896
112Protein digestion and absorption_Homo sapiens_hsa049740.42211101
113Synaptic vesicle cycle_Homo sapiens_hsa047210.41745365
114Chemical carcinogenesis_Homo sapiens_hsa052040.39840283
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39830452
116Asthma_Homo sapiens_hsa053100.39513470
117cAMP signaling pathway_Homo sapiens_hsa040240.38895149
118Regulation of autophagy_Homo sapiens_hsa041400.38595709
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.38313241
120Ovarian steroidogenesis_Homo sapiens_hsa049130.38183241
121Glutamatergic synapse_Homo sapiens_hsa047240.37580311
122Thyroid cancer_Homo sapiens_hsa052160.37396215
123Primary bile acid biosynthesis_Homo sapiens_hsa001200.37250466
124Tight junction_Homo sapiens_hsa045300.37248913
125Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.36988181
126Fanconi anemia pathway_Homo sapiens_hsa034600.36812997
127Pancreatic secretion_Homo sapiens_hsa049720.36008390
128Metabolic pathways_Homo sapiens_hsa011000.35324095
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34815467
130Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34103957
131GABAergic synapse_Homo sapiens_hsa047270.33945733
132Type II diabetes mellitus_Homo sapiens_hsa049300.33847161
133Sulfur relay system_Homo sapiens_hsa041220.33348837
134Amoebiasis_Homo sapiens_hsa051460.32697349
135Fatty acid biosynthesis_Homo sapiens_hsa000610.32625320
136Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32349193
137Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31880394
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31484462
139Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30511357
140Long-term potentiation_Homo sapiens_hsa047200.30402572
141Cocaine addiction_Homo sapiens_hsa050300.30027704
142Morphine addiction_Homo sapiens_hsa050320.29894548
143Homologous recombination_Homo sapiens_hsa034400.27900562
144Ras signaling pathway_Homo sapiens_hsa040140.27871911
145Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26778559
146Gap junction_Homo sapiens_hsa045400.26428794
147Vibrio cholerae infection_Homo sapiens_hsa051100.26363764
148Pathways in cancer_Homo sapiens_hsa052000.25487019
149Aldosterone synthesis and secretion_Homo sapiens_hsa049250.22459671
150Phospholipase D signaling pathway_Homo sapiens_hsa040720.17842601
151Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.17633400
152Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.16963375
153Arachidonic acid metabolism_Homo sapiens_hsa005900.16807985
154GnRH signaling pathway_Homo sapiens_hsa049120.16196948

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