PLTP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1barbed-end actin filament capping (GO:0051016)4.90895361
2keratan sulfate catabolic process (GO:0042340)4.58397938
3amino sugar catabolic process (GO:0046348)4.51896469
4vascular endothelial growth factor signaling pathway (GO:0038084)4.51836770
5glycosphingolipid catabolic process (GO:0046479)4.21830597
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.17467043
7positive regulation by organism of defense response of other organism involved in symbiotic interact4.17467043
8modulation by symbiont of host immune response (GO:0052553)4.17467043
9positive regulation by symbiont of host defense response (GO:0052509)4.17467043
10modulation by symbiont of host defense response (GO:0052031)4.17467043
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.17467043
12glial cell migration (GO:0008347)4.15856990
13adenosine receptor signaling pathway (GO:0001973)3.96130703
14cellular response to thyroid hormone stimulus (GO:0097067)3.84365640
15glycolipid catabolic process (GO:0019377)3.81100032
16cellular response to cadmium ion (GO:0071276)3.79912184
17apoptotic cell clearance (GO:0043277)3.70747447
18positive regulation of cellular amide metabolic process (GO:0034250)3.69466487
19chondroitin sulfate catabolic process (GO:0030207)3.61102343
20low-density lipoprotein particle clearance (GO:0034383)3.58216651
21heart trabecula formation (GO:0060347)3.54321233
22oligosaccharide catabolic process (GO:0009313)3.49884260
23positive regulation of cholesterol efflux (GO:0010875)3.47995421
24regulation of fever generation (GO:0031620)3.46082751
25regulation of interferon-beta biosynthetic process (GO:0045357)3.42821016
26macrophage activation involved in immune response (GO:0002281)3.42604501
27extracellular fibril organization (GO:0043206)3.41578121
28negative regulation of platelet activation (GO:0010544)3.40979240
29positive regulation of actin cytoskeleton reorganization (GO:2000251)3.38426982
30vitamin A metabolic process (GO:0006776)3.34884296
31response to pheromone (GO:0019236)3.34262702
32axon extension involved in axon guidance (GO:0048846)3.31664615
33neuron projection extension involved in neuron projection guidance (GO:1902284)3.31664615
34positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.29325535
35positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)3.27259788
36cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.27051054
37positive regulation of cholesterol transport (GO:0032376)3.26379561
38positive regulation of sterol transport (GO:0032373)3.26379561
39ceramide catabolic process (GO:0046514)3.25230264
40negative regulation of endothelial cell apoptotic process (GO:2000352)3.24245619
41regulation of cholesterol storage (GO:0010885)3.23758744
42positive regulation of dendritic spine morphogenesis (GO:0061003)3.16932839
43positive regulation of lipid kinase activity (GO:0090218)3.15698233
44complement activation, alternative pathway (GO:0006957)3.15024304
45positive regulation of adherens junction organization (GO:1903393)3.13025721
46negative regulation of smooth muscle cell migration (GO:0014912)3.12230798
47positive regulation of macrophage cytokine production (GO:0060907)3.11239147
48peptidyl-glutamic acid carboxylation (GO:0017187)3.10153535
49protein carboxylation (GO:0018214)3.10153535
50detection of molecule of bacterial origin (GO:0032490)3.09643844
51fibril organization (GO:0097435)3.08641700
52sprouting angiogenesis (GO:0002040)3.07375538
53positive regulation of cell junction assembly (GO:1901890)3.07117463
54positive regulation of focal adhesion assembly (GO:0051894)3.07117463
55mannose metabolic process (GO:0006013)3.06637861
56endothelial cell proliferation (GO:0001935)3.06593811
57endothelium development (GO:0003158)3.05151792
58negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.99184984
59regulation of cholesterol efflux (GO:0010874)2.99142902
60dermatan sulfate metabolic process (GO:0030205)2.98072669
61surfactant homeostasis (GO:0043129)2.97779929
62regulation of macrophage chemotaxis (GO:0010758)2.96462073
63membrane lipid catabolic process (GO:0046466)2.96434036
64dermatan sulfate biosynthetic process (GO:0030208)2.96137507
65vitamin transmembrane transport (GO:0035461)2.95692023
66regulation of macrophage cytokine production (GO:0010935)2.93587818
67regulation of membrane protein ectodomain proteolysis (GO:0051043)2.92181345
68regulation of heat generation (GO:0031650)2.89196684
69regulation of endothelial cell differentiation (GO:0045601)2.87338186
70positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.87055623
71regulation of mononuclear cell migration (GO:0071675)2.86883471
72regulation of phosphatidylinositol 3-kinase activity (GO:0043551)2.86271186
73decidualization (GO:0046697)2.85646338
74import into cell (GO:0098657)2.85338209
75sphingolipid catabolic process (GO:0030149)2.85335592
76regulation of integrin-mediated signaling pathway (GO:2001044)2.85202284
77basement membrane organization (GO:0071711)2.84512048
78response to thyroid hormone (GO:0097066)2.82964944
79branching involved in labyrinthine layer morphogenesis (GO:0060670)2.82262747
80alpha-linolenic acid metabolic process (GO:0036109)2.81320713
81iron ion import (GO:0097286)2.81264369
82cellular response to zinc ion (GO:0071294)2.79174934
83cGMP-mediated signaling (GO:0019934)2.78950002
84definitive hemopoiesis (GO:0060216)2.75696030
85negative regulation of nitric oxide biosynthetic process (GO:0045019)2.75128532
86regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.74668632
87regulation of apoptotic cell clearance (GO:2000425)2.74040540
88trabecula formation (GO:0060343)2.72839121
89cyclooxygenase pathway (GO:0019371)2.69664863
90adhesion of symbiont to host cell (GO:0044650)2.68314235
91virion attachment to host cell (GO:0019062)2.68314235
92monocyte chemotaxis (GO:0002548)2.68133644
93lymph vessel development (GO:0001945)2.67928173
94positive regulation of heat generation (GO:0031652)2.67900173
95cell migration involved in heart development (GO:0060973)2.67144934
96regulation of endothelial cell apoptotic process (GO:2000351)2.66593038
97positive regulation of fat cell differentiation (GO:0045600)2.66469720
98opsonization (GO:0008228)2.66091391
99microglial cell activation (GO:0001774)2.65082108
100negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.64204652
101glycosaminoglycan catabolic process (GO:0006027)2.63907527
102vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.62279545
103dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.62080015
104adhesion of symbiont to host (GO:0044406)2.60690325
105antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.60131616
106positive regulation of lipid storage (GO:0010884)2.58920698
107triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.57611279
108macrophage activation (GO:0042116)2.56846994
109aminoglycan catabolic process (GO:0006026)2.56576760
110establishment of endothelial barrier (GO:0061028)2.56161196
111negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.55818726
112response to acidic pH (GO:0010447)2.55223246
113cell adhesion mediated by integrin (GO:0033627)2.54138315
114phagocytosis, engulfment (GO:0006911)2.53325609
115positive regulation of respiratory burst (GO:0060267)2.52907194
116regulation of complement activation (GO:0030449)2.52146427
117response to laminar fluid shear stress (GO:0034616)2.51274061
118response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.51163796
119response to host immune response (GO:0052572)2.51163796
120lytic vacuole organization (GO:0080171)2.49998459
121lysosome organization (GO:0007040)2.49998459
122phagocytosis, recognition (GO:0006910)2.49523283
123endothelial cell chemotaxis (GO:0035767)2.49144537
124plasma lipoprotein particle clearance (GO:0034381)2.48658579
125N-acetylneuraminate metabolic process (GO:0006054)2.47612273
126membrane invagination (GO:0010324)2.47322484
127regulation of sequestering of triglyceride (GO:0010889)2.46675659
128positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.46443642
129antigen processing and presentation of endogenous antigen (GO:0019883)2.46218397
130negative regulation of macrophage differentiation (GO:0045650)2.45587916
131collagen catabolic process (GO:0030574)2.45008101
132regulation of platelet activation (GO:0010543)2.44595860
133regulation of cholesterol esterification (GO:0010872)2.44367181
134regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.44090357
135positive regulation of interferon-alpha production (GO:0032727)2.43498428
136glucosamine-containing compound catabolic process (GO:1901072)2.43359441
137positive regulation of antigen processing and presentation (GO:0002579)2.43271115
138endothelial tube morphogenesis (GO:0061154)2.42642620
139morphogenesis of an endothelium (GO:0003159)2.42642620
140negative regulation of protein localization to cell surface (GO:2000009)2.42297058
141positive regulation of hemostasis (GO:1900048)2.41128726
142positive regulation of blood coagulation (GO:0030194)2.41128726
143response to auditory stimulus (GO:0010996)2.41123023
144collagen metabolic process (GO:0032963)2.41085154
145amyloid precursor protein catabolic process (GO:0042987)2.41038332
146regulation of lipid kinase activity (GO:0043550)2.40658986
147negative regulation of lipid storage (GO:0010888)2.40517492
148low-density lipoprotein particle remodeling (GO:0034374)2.40307280
149retina vasculature morphogenesis in camera-type eye (GO:0061299)2.39404925
150regulation of protein activation cascade (GO:2000257)2.39115877
151cell-cell junction maintenance (GO:0045217)2.38977421
152sulfur compound catabolic process (GO:0044273)2.38845254
153protein heterotrimerization (GO:0070208)2.38088812
154branching involved in salivary gland morphogenesis (GO:0060445)2.37413683
155positive regulation of receptor recycling (GO:0001921)2.37360163
156lymphangiogenesis (GO:0001946)2.37191021
157positive regulation of triglyceride biosynthetic process (GO:0010867)2.36520552
158neuron projection regeneration (GO:0031102)2.36493420
159positive regulation of p38MAPK cascade (GO:1900745)2.35038941
160blood vessel maturation (GO:0001955)2.34071072
161hyaluronan catabolic process (GO:0030214)2.33949682
162positive regulation of phagocytosis (GO:0050766)2.33764996
163tooth mineralization (GO:0034505)2.33647784
164regulation of podosome assembly (GO:0071801)2.32117815
165antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.31737553
166antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.31737553
167vitamin D metabolic process (GO:0042359)2.30489007
168lung epithelium development (GO:0060428)2.30216305
169regulation of interferon-alpha production (GO:0032647)2.29803487
170regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.29712695
171fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.29212638
172response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.29137773
173response to host (GO:0075136)2.29137773
174response to host defenses (GO:0052200)2.29137773
175regulation of antigen processing and presentation (GO:0002577)2.28902881
176extracellular matrix assembly (GO:0085029)2.28309443
177craniofacial suture morphogenesis (GO:0097094)2.28249225
178neutrophil activation involved in immune response (GO:0002283)2.28086124
179regulation of establishment or maintenance of cell polarity (GO:0032878)2.27951711
180negative regulation of leukocyte chemotaxis (GO:0002689)2.27917897
181regulation of vasculogenesis (GO:2001212)2.27433246
182embryo implantation (GO:0007566)2.26862061
183regulation of vitamin D biosynthetic process (GO:0060556)2.25619281
184semaphorin-plexin signaling pathway (GO:0071526)2.25064666

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.12255929
2BP1_19119308_ChIP-ChIP_Hs578T_Human2.97470435
3RARG_19884340_ChIP-ChIP_MEFs_Mouse2.62778003
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.62370773
5IRF8_21731497_ChIP-ChIP_J774_Mouse2.57197830
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.54839106
7Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.37538494
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.35406062
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.29238530
10* IRF8_27001747_Chip-Seq_BMDM_Mouse2.26729694
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.20054727
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.16434572
13CLOCK_20551151_ChIP-Seq_293T_Human2.12951780
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.08396532
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.06936233
16NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.97854676
17GATA2_21666600_ChIP-Seq_HMVEC_Human1.96537733
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.96067262
19LXR_22158963_ChIP-Seq_LIVER_Mouse1.93511154
20ESR1_20079471_ChIP-ChIP_T-47D_Human1.92283809
21RXR_22158963_ChIP-Seq_LIVER_Mouse1.90495043
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.90384057
23CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.89034133
24* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.88691094
25* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86832373
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.84679856
27SRY_22984422_ChIP-ChIP_TESTIS_Rat1.84457665
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.82509052
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73986983
30PPARA_22158963_ChIP-Seq_LIVER_Mouse1.70951279
31EZH2_22144423_ChIP-Seq_EOC_Human1.67781997
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.66939289
33NFIB_24661679_ChIP-Seq_LUNG_Mouse1.64228121
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.63556118
35SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.56965397
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.56561508
37ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.54592591
38* ELK3_25401928_ChIP-Seq_HUVEC_Human1.53311406
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.51060782
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50353521
41CJUN_26792858_Chip-Seq_BT549_Human1.49398138
42ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44893373
43* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.44495318
44NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.42973048
45* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.42590798
46ZNF263_19887448_ChIP-Seq_K562_Human1.41625953
47SMC3_22415368_ChIP-Seq_MEFs_Mouse1.39265770
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.37148530
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.34664414
50PPAR_26484153_Chip-Seq_NCI-H1993_Human1.33113733
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.32712093
52GATA1_19941826_ChIP-Seq_K562_Human1.32617748
53SOX9_24532713_ChIP-Seq_HFSC_Mouse1.30180891
54CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.27842392
55* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26575971
56CDX2_20551321_ChIP-Seq_CACO-2_Human1.26338223
57ESR1_21235772_ChIP-Seq_MCF-7_Human1.24774935
58* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23946188
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23353921
60EED_16625203_ChIP-ChIP_MESCs_Mouse1.23075690
61STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.21273377
62SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.20972813
63SMC1_22415368_ChIP-Seq_MEFs_Mouse1.20672523
64KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.20643604
65KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.20643604
66KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.20643604
67VDR_24787735_ChIP-Seq_THP-1_Human1.20117317
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19433326
69EP300_21415370_ChIP-Seq_HL-1_Mouse1.18550167
70SALL4_18804426_ChIP-ChIP_XEN_Mouse1.17748679
71SA1_22415368_ChIP-Seq_MEFs_Mouse1.17735824
72TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15274121
73SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15058961
74MTF2_20144788_ChIP-Seq_MESCs_Mouse1.14480122
75SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.14316925
76SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13921217
77SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12967786
78RAD21_21589869_ChIP-Seq_MESCs_Mouse1.12464444
79RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12431507
80EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12431507
81SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.12425541
82FOXO3_23340844_ChIP-Seq_DLD1_Human1.12351206
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12315877
84SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09797561
85ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08500657
86SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07138358
87SPI1_23127762_ChIP-Seq_K562_Human1.05942398
88SA1_27219007_Chip-Seq_ERYTHROID_Human1.05288693
89NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04602426
90NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04602426
91PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04199065
92EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03744461
93SOX2_20726797_ChIP-Seq_SW620_Human1.03517889
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03285377
95EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02898809
96SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01657032
97* LXR_22292898_ChIP-Seq_THP-1_Human1.01290195
98ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00657503
99RUNX_20019798_ChIP-Seq_JUKART_Human0.98769474
100MYB_21317192_ChIP-Seq_ERMYB_Mouse0.98392275
101SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.98282594
102CTCF_18555785_ChIP-Seq_MESCs_Mouse0.97863937
103CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.97789156
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97768138
105* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97677407
106SMC4_20622854_ChIP-Seq_HELA_Human0.97614673
107HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97599011
108SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97063405
109SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.96967181
110PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96905010
111STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96004415
112CTCF_27219007_Chip-Seq_Bcells_Human0.95854889
113KDM2B_26808549_Chip-Seq_K562_Human0.95307751
114TBX20_22080862_ChIP-Seq_HEART_Mouse0.95302353
115TBX20_22328084_ChIP-Seq_HEART_Mouse0.95302353
116CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94708857
117TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94594282
118STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94177735
119TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93888509
120PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93779346
121FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.92116800
122P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91829986
123JARID2_20075857_ChIP-Seq_MESCs_Mouse0.91724782
124PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.91238691
125WT1_19549856_ChIP-ChIP_CCG9911_Human0.91138833
126OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91020812
127* TP53_20018659_ChIP-ChIP_R1E_Mouse0.89677408
128GATA1_19941827_ChIP-Seq_MEL_Mouse0.89292181
129GATA2_19941826_ChIP-Seq_K562_Human0.89174039
130RACK7_27058665_Chip-Seq_MCF-7_Human0.88559171
131CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87821778
132DROSHA_22980978_ChIP-Seq_HELA_Human0.87561031
133SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.87248852
134STAT1_20625510_ChIP-Seq_HELA_Human0.87234601
135EZH2_27294783_Chip-Seq_ESCs_Mouse0.86918782
136CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86865230
137* MITF_21258399_ChIP-Seq_MELANOMA_Human0.86252581
138SOX2_18692474_ChIP-Seq_MEFs_Mouse0.85952531
139RXR_22108803_ChIP-Seq_LS180_Human0.85708683
140* FOXA2_19822575_ChIP-Seq_HepG2_Human0.85326747
141BRD4_27068464_Chip-Seq_AML-cells_Mouse0.85059005
142* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85057358
143FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84929068
144KDM2B_26808549_Chip-Seq_DND41_Human0.84634422
145TP53_18474530_ChIP-ChIP_U2OS_Human0.84315968
146KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83978571
147* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83558708
148P300_27058665_Chip-Seq_ZR-75-30cells_Human0.82210357
149SMAD3_21741376_ChIP-Seq_HESCs_Human0.82046150
150ERG_21242973_ChIP-ChIP_JURKAT_Human0.81066382

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005167_abnormal_blood-brain_barrier4.29881777
2MP0003303_peritoneal_inflammation3.84782710
3MP0003011_delayed_dark_adaptation3.74920370
4MP0008438_abnormal_cutaneous_collagen3.31537255
5MP0003191_abnormal_cellular_cholesterol3.26051880
6MP0003724_increased_susceptibility_to3.22744455
7MP0005058_abnormal_lysosome_morphology3.10317112
8MP0003136_yellow_coat_color2.99275734
9MP0009840_abnormal_foam_cell2.83852680
10MP0002254_reproductive_system_inflammat2.76441638
11MP0009278_abnormal_bone_marrow2.62173580
12MP0010368_abnormal_lymphatic_system2.58188926
13MP0003690_abnormal_glial_cell2.51993333
14MP0003705_abnormal_hypodermis_morpholog2.48061739
15MP0001879_abnormal_lymphatic_vessel2.46415527
16MP0005171_absent_coat_pigmentation2.21048714
17MP0005670_abnormal_white_adipose2.16734982
18MP0001958_emphysema1.99676595
19MP0006138_congestive_heart_failure1.99307610
20MP0004272_abnormal_basement_membrane1.98232158
21MP0003075_altered_response_to1.94685913
22MP0006054_spinal_hemorrhage1.91195556
23MP0003828_pulmonary_edema1.91168193
24MP0000604_amyloidosis1.84690650
25MP0005503_abnormal_tendon_morphology1.75253836
26MP0002419_abnormal_innate_immunity1.73363497
27MP0001533_abnormal_skeleton_physiology1.71182404
28MP0003436_decreased_susceptibility_to1.68590351
29MP0006082_CNS_inflammation1.67112359
30MP0000767_abnormal_smooth_muscle1.66474886
31MP0000343_altered_response_to1.63307870
32MP0003634_abnormal_glial_cell1.61947533
33MP0003300_gastrointestinal_ulcer1.56776722
34MP0005508_abnormal_skeleton_morphology1.56195555
35MP0000249_abnormal_blood_vessel1.50790936
36MP0004130_abnormal_muscle_cell1.49679186
37MP0005165_increased_susceptibility_to1.49195196
38MP0005275_abnormal_skin_tensile1.49075373
39MP0001835_abnormal_antigen_presentation1.49036199
40MP0004883_abnormal_blood_vessel1.48890803
41MP0003566_abnormal_cell_adhesion1.47763208
42MP0002139_abnormal_hepatobiliary_system1.44408929
43MP0008004_abnormal_stomach_pH1.44182629
44MP0003186_abnormal_redox_activity1.43986244
45MP0005387_immune_system_phenotype1.43812815
46MP0001790_abnormal_immune_system1.43812815
47MP0005164_abnormal_response_to1.43132531
48MP0003279_aneurysm1.41922008
49MP0000920_abnormal_myelination1.39031861
50MP0001853_heart_inflammation1.36087951
51MP0008875_abnormal_xenobiotic_pharmacok1.35507005
52MP0002653_abnormal_ependyma_morphology1.35476099
53MP0002837_dystrophic_cardiac_calcinosis1.34994603
54MP0000685_abnormal_immune_system1.34040855
55MP0005083_abnormal_biliary_tract1.33874352
56MP0005360_urolithiasis1.31329378
57MP0004510_myositis1.24974253
58MP0010030_abnormal_orbit_morphology1.23480254
59MP0004782_abnormal_surfactant_physiolog1.22871407
60MP0005166_decreased_susceptibility_to1.21252678
61MP0003950_abnormal_plasma_membrane1.16941579
62MP0002998_abnormal_bone_remodeling1.15110356
63MP0000751_myopathy1.14567380
64MP0005000_abnormal_immune_tolerance1.12522815
65MP0003172_abnormal_lysosome_physiology1.12201376
66MP0005025_abnormal_response_to1.12037605
67MP0003448_altered_tumor_morphology1.10666028
68MP0002332_abnormal_exercise_endurance1.10478664
69MP0002138_abnormal_hepatobiliary_system1.10449539
70MP0001542_abnormal_bone_strength1.09108782
71MP0002133_abnormal_respiratory_system1.07060247
72MP0005388_respiratory_system_phenotype1.07060247
73* MP0010329_abnormal_lipoprotein_level1.06784377
74MP0002295_abnormal_pulmonary_circulatio1.03693773
75MP0005076_abnormal_cell_differentiation1.03620088
76MP0005623_abnormal_meninges_morphology1.02088361
77MP0002148_abnormal_hypersensitivity_rea1.01857960
78MP0009764_decreased_sensitivity_to1.01111718
79MP0005464_abnormal_platelet_physiology1.00301205
80MP0001984_abnormal_olfaction0.99642091
81* MP0004019_abnormal_vitamin_homeostasis0.98794138
82MP0005367_renal/urinary_system_phenotyp0.97864102
83MP0000516_abnormal_urinary_system0.97864102
84MP0002452_abnormal_antigen_presenting0.96623661
85MP0002933_joint_inflammation0.96420125
86MP0009785_altered_susceptibility_to0.95377066
87MP0005023_abnormal_wound_healing0.95294918
88MP0002405_respiratory_system_inflammati0.95247241
89MP0009384_cardiac_valve_regurgitation0.94585249
90MP0003091_abnormal_cell_migration0.92926127
91MP0001324_abnormal_eye_pigmentation0.92267882
92MP0005595_abnormal_vascular_smooth0.91359379
93MP0000858_altered_metastatic_potential0.90414364
94MP0002896_abnormal_bone_mineralization0.90328725
95MP0002166_altered_tumor_susceptibility0.90278178
96MP0001873_stomach_inflammation0.89758686
97MP0003878_abnormal_ear_physiology0.89361241
98MP0005377_hearing/vestibular/ear_phenot0.89361241
99MP0000733_abnormal_muscle_development0.89165204
100MP0005390_skeleton_phenotype0.89001641
101MP0001545_abnormal_hematopoietic_system0.88044531
102MP0005397_hematopoietic_system_phenotyp0.88044531
103MP0003329_amyloid_beta_deposits0.87569711
104MP0001915_intracranial_hemorrhage0.87278984
105MP0001851_eye_inflammation0.85899639
106MP0001614_abnormal_blood_vessel0.85331588
107MP0003632_abnormal_nervous_system0.84967821
108MP0001544_abnormal_cardiovascular_syste0.83619546
109MP0005385_cardiovascular_system_phenoty0.83619546
110MP0004484_altered_response_of0.83536347
111MP0003633_abnormal_nervous_system0.83183153
112MP0001845_abnormal_inflammatory_respons0.82091414
113MP0008260_abnormal_autophagy0.81940407
114MP0008469_abnormal_protein_level0.81110404
115MP0002136_abnormal_kidney_physiology0.80734158
116MP0002128_abnormal_blood_circulation0.80488213
117MP0001849_ear_inflammation0.80354845
118MP0005257_abnormal_intraocular_pressure0.80078877
119MP0005253_abnormal_eye_physiology0.78295759
120MP0005666_abnormal_adipose_tissue0.77240665
121MP0002090_abnormal_vision0.77049807
122MP0009763_increased_sensitivity_to0.76781351
123MP0002108_abnormal_muscle_morphology0.76032024
124MP0003453_abnormal_keratinocyte_physiol0.75009002
125MP0004858_abnormal_nervous_system0.73683233
126MP0001756_abnormal_urination0.73603246
127MP0004947_skin_inflammation0.73254041
128MP0003795_abnormal_bone_structure0.71317127
129MP0003879_abnormal_hair_cell0.69372034
130MP0002971_abnormal_brown_adipose0.67259525
131MP0005365_abnormal_bile_salt0.67139510
132MP0003631_nervous_system_phenotype0.63949680
133MP0000026_abnormal_inner_ear0.63156035
134MP0003283_abnormal_digestive_organ0.63130352
135MP0003137_abnormal_impulse_conducting0.63079319
136MP0000750_abnormal_muscle_regeneration0.63078696
137MP0002638_abnormal_pupillary_reflex0.62098351
138MP0005197_abnormal_uvea_morphology0.61465804
139MP0004133_heterotaxia0.61090942
140MP0000163_abnormal_cartilage_morphology0.59522051
141MP0002089_abnormal_postnatal_growth/wei0.57602204
142MP0005375_adipose_tissue_phenotype0.56908355

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)6.93667857
2Nuclear cataract (HP:0100018)4.91980252
3Complement deficiency (HP:0004431)4.45139581
4Increased cerebral lipofuscin (HP:0011813)4.36547385
5Glomerulonephritis (HP:0000099)4.31112875
6Dysostosis multiplex (HP:0000943)3.99671764
7Abnormality of complement system (HP:0005339)3.91667224
8Abnormality of the nasal mucosa (HP:0000433)3.91168515
9Increased CSF protein (HP:0002922)3.89568329
10Vacuolated lymphocytes (HP:0001922)3.88274798
11Mutism (HP:0002300)3.79804412
12Vertebral compression fractures (HP:0002953)3.68023536
13Recurrent abscess formation (HP:0002722)3.50034411
14Esophageal varix (HP:0002040)3.48889564
15Urinary glycosaminoglycan excretion (HP:0003541)3.41534590
16Mucopolysacchariduria (HP:0008155)3.41534590
17Nephritis (HP:0000123)3.41423554
18Joint hemorrhage (HP:0005261)3.40982651
19Recurrent gram-negative bacterial infections (HP:0005420)3.26704770
20Eczematoid dermatitis (HP:0000976)3.21513608
21Abnormality of mucopolysaccharide metabolism (HP:0011020)3.18691111
22Abnormality of polysaccharide metabolism (HP:0011012)3.18691111
23Abnormality of glycosaminoglycan metabolism (HP:0004371)3.18691111
24Increased neuronal autofluorescent lipopigment (HP:0002074)3.11056534
25Nasal polyposis (HP:0100582)3.09189085
26Loss of speech (HP:0002371)3.08213113
27Cerebral aneurysm (HP:0004944)3.00489645
28Deep venous thrombosis (HP:0002625)2.99217805
29Annular pancreas (HP:0001734)2.98359110
30Spontaneous hematomas (HP:0007420)2.94478587
31Broad metatarsal (HP:0001783)2.89627873
32Abnormality of glycolipid metabolism (HP:0010969)2.88819152
33Abnormality of liposaccharide metabolism (HP:0010968)2.88819152
34Abnormality of glycosphingolipid metabolism (HP:0004343)2.88819152
35Petechiae (HP:0000967)2.85327112
36Polyphagia (HP:0002591)2.85240562
37Recurrent bacterial skin infections (HP:0005406)2.82085916
38Axonal loss (HP:0003447)2.81771845
39Autoimmune thrombocytopenia (HP:0001973)2.81719213
40Hematochezia (HP:0002573)2.76598047
41Arterial tortuosity (HP:0005116)2.75114882
42Protrusio acetabuli (HP:0003179)2.67376441
43Vascular tortuosity (HP:0004948)2.63475260
44Asymmetric septal hypertrophy (HP:0001670)2.62164318
45Abnormality of macrophages (HP:0004311)2.55480171
46Myocardial infarction (HP:0001658)2.53826903
47Apathy (HP:0000741)2.53624332
48Abnormality of the vasculature of the conjunctiva (HP:0008054)2.52713665
49Polycythemia (HP:0001901)2.52018476
50Diminished motivation (HP:0000745)2.47862213
51Turricephaly (HP:0000262)2.45993472
52Conjunctival telangiectasia (HP:0000524)2.40680341
53Joint stiffness (HP:0001387)2.38988077
54Adactyly (HP:0009776)2.36468609
55Mesangial abnormality (HP:0001966)2.35776981
56Prolonged neonatal jaundice (HP:0006579)2.32887458
57Aortic dissection (HP:0002647)2.32504101
58Neurofibrillary tangles (HP:0002185)2.30686429
59White forelock (HP:0002211)2.30513214
60Dementia (HP:0000726)2.29546242
61Xanthomatosis (HP:0000991)2.26392994
62Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.25364408
63Progressive neurologic deterioration (HP:0002344)2.24910618
64Shallow orbits (HP:0000586)2.23726576
65Retinal atrophy (HP:0001105)2.22310568
66Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.22124343
67Spondylolisthesis (HP:0003302)2.21432079
68Supranuclear gaze palsy (HP:0000605)2.19688489
69Abnormality of the lumbar spine (HP:0100712)2.17926119
70Amyloidosis (HP:0011034)2.16083787
71Beaking of vertebral bodies (HP:0004568)2.13150386
72Interstitial pulmonary disease (HP:0006530)2.07446978
73Patchy hypopigmentation of hair (HP:0011365)2.06764227
74Premature rupture of membranes (HP:0001788)2.05789945
75Aortic aneurysm (HP:0004942)2.02477635
76Thick nail (HP:0001805)2.01675482
77Disinhibition (HP:0000734)2.01549413
78Osteolytic defects of the phalanges of the hand (HP:0009771)2.00941356
79Osteolytic defects of the hand bones (HP:0009699)2.00941356
80Pathologic fracture (HP:0002756)1.98458412
81Decreased electroretinogram (ERG) amplitude (HP:0000654)1.97164100
82Gastrointestinal infarctions (HP:0005244)1.96317082
83Prolonged partial thromboplastin time (HP:0003645)1.95577954
84Poor head control (HP:0002421)1.94823360
85Hypercholesterolemia (HP:0003124)1.94758550
86Neoplasm of head and neck (HP:0012288)1.93178395
87Esophageal neoplasm (HP:0100751)1.93178395
88Mitral valve prolapse (HP:0001634)1.93133555
89Rectal prolapse (HP:0002035)1.92652888
90Tetraparesis (HP:0002273)1.92359343
91Bronchomalacia (HP:0002780)1.91725465
92Colitis (HP:0002583)1.90905176
93J-shaped sella turcica (HP:0002680)1.89131238
94Hepatosplenomegaly (HP:0001433)1.88764609
95Porencephaly (HP:0002132)1.86913479
96Gingivitis (HP:0000230)1.86257012
97Absent hand (HP:0004050)1.85983655
98Neuronal loss in central nervous system (HP:0002529)1.84545865
99Patent foramen ovale (HP:0001655)1.84178221
100Disproportionate tall stature (HP:0001519)1.84042706
101Metaphyseal irregularity (HP:0003025)1.80413529
102Skin nodule (HP:0200036)1.79128291
103Pulmonary artery stenosis (HP:0004415)1.78670397
104Zonular cataract (HP:0010920)1.78248805
105Cervical subluxation (HP:0003308)1.77339182
106Peripheral demyelination (HP:0011096)1.75396566
107Ulnar bowing (HP:0003031)1.74827742
108Growth hormone excess (HP:0000845)1.74431552
109Abnormality of the common coagulation pathway (HP:0010990)1.74419441
110Bladder diverticulum (HP:0000015)1.74116821
111Peritonitis (HP:0002586)1.73880561
112Cerebral inclusion bodies (HP:0100314)1.73609339
113Microretrognathia (HP:0000308)1.73533155
114Diplopia (HP:0000651)1.72383212
115Abnormality of binocular vision (HP:0011514)1.72383212
116Abnormality of the vertebral endplates (HP:0005106)1.71430425
117Hyperinsulinemic hypoglycemia (HP:0000825)1.70008089
118Upper motor neuron abnormality (HP:0002127)1.69387111
119Recurrent skin infections (HP:0001581)1.69092069
120Ovoid vertebral bodies (HP:0003300)1.68917042
121Epidermoid cyst (HP:0200040)1.68397189
122Peripheral hypomyelination (HP:0007182)1.67114454
123Mitral stenosis (HP:0001718)1.66990072
124Purpura (HP:0000979)1.66655171
125Irregular vertebral endplates (HP:0003301)1.66433749
126Thoracic kyphosis (HP:0002942)1.66336214
127Agnosia (HP:0010524)1.64968614
128Portal hypertension (HP:0001409)1.64460276
129Hemorrhage of the eye (HP:0011885)1.64438731
130Split foot (HP:0001839)1.63593589
131Short femoral neck (HP:0100864)1.62810452
132Bone cyst (HP:0012062)1.62622838
133Tetany (HP:0001281)1.61549316
134Scapular winging (HP:0003691)1.60384451
135Persistence of primary teeth (HP:0006335)1.59970473
136Abnormal eating behavior (HP:0100738)1.59915653
137Cardiomegaly (HP:0001640)1.59484692
138Aplasia involving bones of the upper limbs (HP:0009823)1.58546180
139Aplasia of the phalanges of the hand (HP:0009802)1.58546180
140Aplasia involving bones of the extremities (HP:0009825)1.58546180
141Striae distensae (HP:0001065)1.58177823
142Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.56329551
143Coronal craniosynostosis (HP:0004440)1.55782281
144Choanal stenosis (HP:0000452)1.55393838
145Atelectasis (HP:0100750)1.54045719
146Aortic valve stenosis (HP:0001650)1.53420646
147Craniofacial dystonia (HP:0012179)1.53147370
148Bone pain (HP:0002653)1.52839073
149Flared iliac wings (HP:0002869)1.51865777
150Stroke (HP:0001297)1.51297761

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D3.71256151
2BMX2.98832153
3GRK12.87789060
4CAMK1G2.85059070
5NME22.83317562
6TGFBR22.61941581
7PIM22.48409810
8TESK12.26041398
9TEC2.07708812
10BCKDK2.07371460
11TIE112.0107451
12TYRO31.78521469
13ERN11.66756283
14MAP3K111.58284180
15CDC42BPA1.55107174
16KDR1.49200118
17RIPK11.46597046
18MOS1.41185501
19LIMK11.39847641
20EPHB11.34989390
21LATS21.31823824
22TRIB31.27733699
23TTN1.27727217
24TYK21.25260945
25BLK1.23476945
26NTRK21.21919285
27ADRBK21.18591759
28TAOK11.07546954
29PTK61.07425275
30MAPK151.04300744
31PKN11.03869139
32PAK40.97345004
33FGFR40.96743631
34MYLK0.93823542
35EPHB20.92044192
36KIT0.91590555
37PDGFRB0.91465728
38ROCK20.90358071
39MST1R0.86172504
40JAK10.85932752
41CSK0.85500619
42LMTK20.81982931
43ICK0.80831144
44CSNK1G20.80434132
45TNIK0.80211630
46TBK10.79329034
47SIK10.79218771
48TRPM70.78985477
49MAP2K20.78454405
50ARAF0.75792736
51TESK20.75268639
52CAMK2G0.75051549
53RIPK40.72859500
54TAOK20.72174812
55PDGFRA0.68690783
56CSNK1G30.67293723
57PRKD20.66005246
58DAPK20.65840170
59EGFR0.62362476
60MARK20.62292498
61INSRR0.61850803
62GRK70.61339849
63FGR0.61106089
64CAMK2D0.60303404
65STK160.60289601
66ZAP700.59902966
67PTK2B0.57957060
68DDR20.57656158
69PKN20.57637510
70STK100.57430186
71MAPK40.56875386
72MET0.56585632
73IRAK30.55933407
74RPS6KA20.55002377
75PAK20.54365580
76ROCK10.54357619
77ERBB20.54283609
78LRRK20.53641471
79HCK0.53379889
80FES0.53182960
81MAPK70.51219030
82PRKCH0.51206688
83DYRK30.51147876
84PDPK10.50685853
85GSK3A0.50604736
86SGK30.49818418
87CSNK1G10.49416243
88TSSK60.49372851
89DAPK30.48599818
90MAP3K30.48388265
91TAOK30.48309091
92CAMK40.47085115
93CDK140.46839028
94PRKCE0.46378520
95DYRK1B0.45852886
96NTRK10.45301284
97JAK20.45047403
98ERBB40.43464538
99MAP3K140.43335969
100IRAK10.43093636
101CDK11A0.43055786
102MAP3K10.43047867
103SRC0.42630096
104CSNK1A1L0.41830128
105CDK150.41433349
106TGFBR10.41332422
107RPS6KC10.40994274
108RPS6KL10.40994274
109PRKAA20.40376743
110FGFR30.40183037
111MAP3K50.40099609
112PRKG20.39578256
113LYN0.39410587
114PINK10.38805531
115CLK10.38559671
116DYRK20.38384393
117MAPK120.38176471
118MAP3K60.37547942
119RPS6KA60.37007081
120INSR0.36532010
121PTK20.36222249
122DMPK0.36148394
123IKBKE0.36132176
124FYN0.36099220
125SGK20.35525291
126PRKD10.35019659
127IGF1R0.34629798
128EPHA30.34337868
129CAMKK10.34242299
130MAPKAPK30.34190143
131NEK90.33432899
132IKBKB0.31819790
133IRAK40.31188302
134MAPKAPK20.31124356
135MAP4K10.30457140
136MAP3K120.30415790
137MAP2K10.30343900
138ABL10.30315406
139PRKCG0.30178548
140PRKCD0.29650776
141FER0.29118250
142FGFR20.26962691
143CSF1R0.26142879
144MATK0.25710095
145ABL20.25172939
146CDK60.24367195
147PRPF4B0.23918593
148ITK0.23730120

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.07247551
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.30677344
3Complement and coagulation cascades_Homo sapiens_hsa046102.73307225
4Other glycan degradation_Homo sapiens_hsa005112.43670873
5Lysosome_Homo sapiens_hsa041422.31378754
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.24074096
7Rheumatoid arthritis_Homo sapiens_hsa053232.17255878
8Nitrogen metabolism_Homo sapiens_hsa009102.05171786
9Caffeine metabolism_Homo sapiens_hsa002321.98207882
10Collecting duct acid secretion_Homo sapiens_hsa049661.93213034
11Bile secretion_Homo sapiens_hsa049761.79258174
12Pertussis_Homo sapiens_hsa051331.69053151
13Galactose metabolism_Homo sapiens_hsa000521.62860847
14Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.60044561
15* PPAR signaling pathway_Homo sapiens_hsa033201.58986954
16Malaria_Homo sapiens_hsa051441.54643230
17Vibrio cholerae infection_Homo sapiens_hsa051101.53974882
18Leishmaniasis_Homo sapiens_hsa051401.49893493
19Steroid biosynthesis_Homo sapiens_hsa001001.47223825
20Prion diseases_Homo sapiens_hsa050201.33009403
21Glutathione metabolism_Homo sapiens_hsa004801.32931504
22Fatty acid elongation_Homo sapiens_hsa000621.31645923
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26643328
24Osteoclast differentiation_Homo sapiens_hsa043801.25222994
25Tuberculosis_Homo sapiens_hsa051521.22247269
26Notch signaling pathway_Homo sapiens_hsa043301.21451903
27Phagosome_Homo sapiens_hsa041451.20744719
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.19587438
29HIF-1 signaling pathway_Homo sapiens_hsa040661.19528020
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.19238176
31Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.15726317
32Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.15471370
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.14310049
34Amoebiasis_Homo sapiens_hsa051461.09933095
35ECM-receptor interaction_Homo sapiens_hsa045121.06333135
36Toxoplasmosis_Homo sapiens_hsa051451.04527426
37Focal adhesion_Homo sapiens_hsa045100.97136857
38Adherens junction_Homo sapiens_hsa045200.95417991
39Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94361960
40Antigen processing and presentation_Homo sapiens_hsa046120.93756851
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93621779
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92633381
43Asthma_Homo sapiens_hsa053100.92014772
44ABC transporters_Homo sapiens_hsa020100.90187071
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89575204
46Adipocytokine signaling pathway_Homo sapiens_hsa049200.88461643
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87870049
48Mineral absorption_Homo sapiens_hsa049780.87745285
49Vitamin B6 metabolism_Homo sapiens_hsa007500.87199753
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86665184
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86218831
52Proteoglycans in cancer_Homo sapiens_hsa052050.85659643
53Protein digestion and absorption_Homo sapiens_hsa049740.83637631
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83302904
55Endocytosis_Homo sapiens_hsa041440.82095662
56Rap1 signaling pathway_Homo sapiens_hsa040150.80512906
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76972685
58Sphingolipid metabolism_Homo sapiens_hsa006000.76032912
59Bladder cancer_Homo sapiens_hsa052190.75312942
60Chemokine signaling pathway_Homo sapiens_hsa040620.74914232
61Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74709513
62Arginine biosynthesis_Homo sapiens_hsa002200.73590035
63Renin-angiotensin system_Homo sapiens_hsa046140.72115063
64Ovarian steroidogenesis_Homo sapiens_hsa049130.72032050
65Renal cell carcinoma_Homo sapiens_hsa052110.70592149
66Synaptic vesicle cycle_Homo sapiens_hsa047210.70161717
67Gastric acid secretion_Homo sapiens_hsa049710.68362115
68Histidine metabolism_Homo sapiens_hsa003400.67553884
69Salmonella infection_Homo sapiens_hsa051320.67431619
70Legionellosis_Homo sapiens_hsa051340.67356710
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66045692
72Platelet activation_Homo sapiens_hsa046110.65311561
73TNF signaling pathway_Homo sapiens_hsa046680.64859515
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64693335
75Fatty acid degradation_Homo sapiens_hsa000710.64337219
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64270569
77Oxidative phosphorylation_Homo sapiens_hsa001900.63488231
78Sulfur metabolism_Homo sapiens_hsa009200.63440451
79Dilated cardiomyopathy_Homo sapiens_hsa054140.62815731
80Dorso-ventral axis formation_Homo sapiens_hsa043200.62618006
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62256560
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61725772
83Tryptophan metabolism_Homo sapiens_hsa003800.60608808
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60574243
85Sulfur relay system_Homo sapiens_hsa041220.60507941
86Chemical carcinogenesis_Homo sapiens_hsa052040.59943803
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59933169
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58762241
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.58293514
90African trypanosomiasis_Homo sapiens_hsa051430.58187836
91Basal cell carcinoma_Homo sapiens_hsa052170.57864246
92B cell receptor signaling pathway_Homo sapiens_hsa046620.56890696
93beta-Alanine metabolism_Homo sapiens_hsa004100.56556227
94Estrogen signaling pathway_Homo sapiens_hsa049150.56220353
95Insulin resistance_Homo sapiens_hsa049310.56021960
96Tyrosine metabolism_Homo sapiens_hsa003500.54908672
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54525376
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52273702
99Hepatitis C_Homo sapiens_hsa051600.50671672
100Arginine and proline metabolism_Homo sapiens_hsa003300.50557196
101TGF-beta signaling pathway_Homo sapiens_hsa043500.49961216
102PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49643990
103Phenylalanine metabolism_Homo sapiens_hsa003600.48934263
104Ras signaling pathway_Homo sapiens_hsa040140.48857313
105Retinol metabolism_Homo sapiens_hsa008300.48489879
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47868726
107Viral myocarditis_Homo sapiens_hsa054160.47335172
108Chronic myeloid leukemia_Homo sapiens_hsa052200.46569613
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46456023
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46239546
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.46191695
112Small cell lung cancer_Homo sapiens_hsa052220.45596025
113Folate biosynthesis_Homo sapiens_hsa007900.45531311
114Apoptosis_Homo sapiens_hsa042100.45027177
115Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44329786
116Glycerolipid metabolism_Homo sapiens_hsa005610.44195030
117Fatty acid metabolism_Homo sapiens_hsa012120.43344330
118Arachidonic acid metabolism_Homo sapiens_hsa005900.42909471
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41938866
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.41902545
121Hematopoietic cell lineage_Homo sapiens_hsa046400.41014034
122Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40378557
123Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40214812
124Melanogenesis_Homo sapiens_hsa049160.37315940
125Shigellosis_Homo sapiens_hsa051310.37089697
126Fructose and mannose metabolism_Homo sapiens_hsa000510.36502050
127Influenza A_Homo sapiens_hsa051640.36429827
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.36253595
129Gap junction_Homo sapiens_hsa045400.34574329
130Vascular smooth muscle contraction_Homo sapiens_hsa042700.34220770
131Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31626198
132Carbon metabolism_Homo sapiens_hsa012000.30646422
133Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28393148
134Pentose phosphate pathway_Homo sapiens_hsa000300.27118171
135Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26936061
136Axon guidance_Homo sapiens_hsa043600.26653722
137Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22144473
138Alzheimers disease_Homo sapiens_hsa050100.21922192
139Pyruvate metabolism_Homo sapiens_hsa006200.21009915
140Renin secretion_Homo sapiens_hsa049240.20056019

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