PLXDC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of chemokine secretion (GO:0090197)4.60451741
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.05930345
3positive regulation of gamma-delta T cell activation (GO:0046645)4.05627737
4microglial cell activation (GO:0001774)4.05508558
5detection of external biotic stimulus (GO:0098581)4.01816167
6positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.95876459
7positive regulation of mast cell activation (GO:0033005)3.95816134
8detection of other organism (GO:0098543)3.83945631
9positive regulation by symbiont of host defense response (GO:0052509)3.70961054
10modulation by symbiont of host defense response (GO:0052031)3.70961054
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.70961054
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.70961054
13positive regulation by organism of defense response of other organism involved in symbiotic interact3.70961054
14modulation by symbiont of host immune response (GO:0052553)3.70961054
15detection of biotic stimulus (GO:0009595)3.62517883
16negative regulation of interleukin-12 production (GO:0032695)3.62119154
17regulation of chemokine secretion (GO:0090196)3.49139285
18cellular response to thyroid hormone stimulus (GO:0097067)3.48982936
19positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.43390884
20G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.40917088
21macrophage activation involved in immune response (GO:0002281)3.39334868
22apoptotic cell clearance (GO:0043277)3.35465007
23regulation of myeloid leukocyte mediated immunity (GO:0002886)3.32156514
24wound healing, spreading of epidermal cells (GO:0035313)3.28121383
25detection of bacterium (GO:0016045)3.24594233
26regulation of mast cell degranulation (GO:0043304)3.20985516
27regulation of mononuclear cell migration (GO:0071675)3.16737119
28regulation of mast cell activation (GO:0033003)3.16161135
29neutrophil activation involved in immune response (GO:0002283)3.10201681
30regulation of mast cell activation involved in immune response (GO:0033006)3.09218803
31positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.03191243
32regulation of gamma-delta T cell activation (GO:0046643)2.96510839
33regulation of interferon-beta biosynthetic process (GO:0045357)2.95283898
34glycosphingolipid catabolic process (GO:0046479)2.94616166
35positive regulation of cellular amide metabolic process (GO:0034250)2.94162122
36regulation of leukocyte degranulation (GO:0043300)2.92665687
37cellular response to ethanol (GO:0071361)2.91867057
38negative regulation of cell killing (GO:0031342)2.91116995
39negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.91116995
40regulation of hypersensitivity (GO:0002883)2.90914546
41immunoglobulin mediated immune response (GO:0016064)2.90446205
42central nervous system myelination (GO:0022010)2.81857155
43axon ensheathment in central nervous system (GO:0032291)2.81857155
44phagocytosis, engulfment (GO:0006911)2.81715403
45cellular extravasation (GO:0045123)2.80987542
46virion attachment to host cell (GO:0019062)2.80717951
47adhesion of symbiont to host cell (GO:0044650)2.80717951
48long-chain fatty acid biosynthetic process (GO:0042759)2.80302148
49regulation of macrophage cytokine production (GO:0010935)2.79649933
50amino sugar catabolic process (GO:0046348)2.79226454
51positive regulation of macrophage cytokine production (GO:0060907)2.76593449
52negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.75791014
53oligosaccharide catabolic process (GO:0009313)2.74095362
54regulation of platelet activation (GO:0010543)2.72180435
55keratan sulfate catabolic process (GO:0042340)2.70830151
56G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.70120549
57regulation of monocyte chemotaxis (GO:0090025)2.67141091
58positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.66515959
59positive regulation of monocyte chemotaxis (GO:0090026)2.65947317
60regulation of chemokine-mediated signaling pathway (GO:0070099)2.63902945
61positive regulation of bone resorption (GO:0045780)2.62965714
62positive regulation of bone remodeling (GO:0046852)2.62965714
63macrophage activation (GO:0042116)2.61894957
64glycolipid catabolic process (GO:0019377)2.61298209
65neutrophil chemotaxis (GO:0030593)2.60972997
66adenosine receptor signaling pathway (GO:0001973)2.60445356
67cyclooxygenase pathway (GO:0019371)2.59855150
68positive regulation of cholesterol efflux (GO:0010875)2.59124044
69purinergic nucleotide receptor signaling pathway (GO:0035590)2.59020168
70wound healing, spreading of cells (GO:0044319)2.58727979
71response to muramyl dipeptide (GO:0032495)2.58484517
72positive regulation of toll-like receptor signaling pathway (GO:0034123)2.57347554
73respiratory burst (GO:0045730)2.56729385
74regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.55240112
75neutrophil migration (GO:1990266)2.54632346
76leukocyte migration involved in inflammatory response (GO:0002523)2.52147965
77regulation of gamma-delta T cell differentiation (GO:0045586)2.51539904
78response to peptidoglycan (GO:0032494)2.51421359
79regulation of beta-amyloid formation (GO:1902003)2.49416617
80regulation of macrophage chemotaxis (GO:0010758)2.48013653
81myeloid cell activation involved in immune response (GO:0002275)2.47096770
82positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.46965563
83glomerular basement membrane development (GO:0032836)2.44648725
84positive regulation of B cell differentiation (GO:0045579)2.43132993
85negative regulation of erythrocyte differentiation (GO:0045647)2.40845252
86positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.40776494
87cell adhesion mediated by integrin (GO:0033627)2.39768495
88positive regulation of astrocyte differentiation (GO:0048711)2.38665132
89regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.37470679
90regulation of B cell receptor signaling pathway (GO:0050855)2.37348126
91regulation of regulated secretory pathway (GO:1903305)2.36568603
92lipoxygenase pathway (GO:0019372)2.36278193
93regulation of cholesterol storage (GO:0010885)2.35993309
94regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.35657169
95interferon-gamma-mediated signaling pathway (GO:0060333)2.35194056
96response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.35044330
97response to host immune response (GO:0052572)2.35044330
98purinergic receptor signaling pathway (GO:0035587)2.33085324
99granulocyte chemotaxis (GO:0071621)2.32996930
100regulation of T-helper 2 cell differentiation (GO:0045628)2.32748080
101cortical actin cytoskeleton organization (GO:0030866)2.32396488
102epithelial cell differentiation involved in prostate gland development (GO:0060742)2.32054093
103membrane raft organization (GO:0031579)2.31894123
104granulocyte activation (GO:0036230)2.31015251
105phagocytosis, recognition (GO:0006910)2.30981794
106collagen fibril organization (GO:0030199)2.30889376
107extracellular matrix assembly (GO:0085029)2.30737039
108nerve growth factor signaling pathway (GO:0038180)2.30711946
109ceramide catabolic process (GO:0046514)2.30422497
110production of molecular mediator involved in inflammatory response (GO:0002532)2.30349896
111regulation of platelet aggregation (GO:0090330)2.30097883
112positive regulation of antigen processing and presentation (GO:0002579)2.30032379
113detection of molecule of bacterial origin (GO:0032490)2.29816456
114positive regulation of cholesterol transport (GO:0032376)2.29652654
115negative regulation of interleukin-17 production (GO:0032700)2.29575180
116response to laminar fluid shear stress (GO:0034616)2.27815002
117T-helper 1 type immune response (GO:0042088)2.27618858
118response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.26816848
119response to host (GO:0075136)2.26816848
120response to host defenses (GO:0052200)2.26816848
121superoxide anion generation (GO:0042554)2.26634347
122positive regulation of interferon-alpha production (GO:0032727)2.26147017
123neutrophil activation (GO:0042119)2.25821834
124cellular response to interferon-alpha (GO:0035457)2.24339796
125response to lipoprotein particle (GO:0055094)2.21891253
126cortical cytoskeleton organization (GO:0030865)2.21749222
127chondroitin sulfate catabolic process (GO:0030207)2.20835552
128positive regulation of mast cell degranulation (GO:0043306)2.20780262
129positive regulation of mast cell activation involved in immune response (GO:0033008)2.20780262
130negative regulation of granulocyte differentiation (GO:0030853)2.18626232
131import into cell (GO:0098657)2.16978762
132monocyte chemotaxis (GO:0002548)2.15738236
133axon ensheathment (GO:0008366)2.15072537
134ensheathment of neurons (GO:0007272)2.15072537
135regulation of lymphocyte migration (GO:2000401)2.14561489
136regulation of T cell migration (GO:2000404)2.14550820
137negative regulation of interleukin-6 production (GO:0032715)2.13331947
138myelination (GO:0042552)2.12902975
139lipopolysaccharide-mediated signaling pathway (GO:0031663)2.12404114
140regulation of antigen processing and presentation (GO:0002577)2.12167654
141endodermal cell differentiation (GO:0035987)2.11767156
142glomerular visceral epithelial cell development (GO:0072015)2.10962867
143platelet-derived growth factor receptor signaling pathway (GO:0048008)2.10927496
144positive regulation of chemokine production (GO:0032722)2.10924845
145regulation of interferon-alpha production (GO:0032647)2.10167849
146positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.09306933
147germinal center formation (GO:0002467)2.09092072
148positive regulation of interleukin-6 production (GO:0032755)2.05991691
149positive regulation of leukocyte degranulation (GO:0043302)2.05097205
150negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.05044496
151adhesion of symbiont to host (GO:0044406)2.04811252
152positive regulation of T cell chemotaxis (GO:0010820)2.04672906
153regulation of T cell chemotaxis (GO:0010819)2.04672906

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.67345195
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.08261599
3IRF8_21731497_ChIP-ChIP_J774_Mouse2.98491730
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.79633730
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.75291912
6IRF8_27001747_Chip-Seq_BMDM_Mouse2.52621826
7GATA1_22025678_ChIP-Seq_K562_Human2.39659757
8Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.27075077
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.14579334
10SMAD_19615063_ChIP-ChIP_OVARY_Human1.99845706
11CDX2_19796622_ChIP-Seq_MESCs_Mouse1.97702522
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.95323601
13VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.87607140
14ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.75681932
15IRF8_22096565_ChIP-ChIP_GC-B_Human1.73892541
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66133350
17* CJUN_26792858_Chip-Seq_BT549_Human1.65382820
18* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62560970
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.53416557
20* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.52905396
21GBX2_23144817_ChIP-Seq_PC3_Human1.52138941
22* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.51752479
23* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.51752479
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.51382952
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.50442373
26TP53_16413492_ChIP-PET_HCT116_Human1.49606685
27WT1_19549856_ChIP-ChIP_CCG9911_Human1.49042066
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46855432
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.46825368
30VDR_24787735_ChIP-Seq_THP-1_Human1.45584873
31TP53_18474530_ChIP-ChIP_U2OS_Human1.45510519
32* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.45345270
33* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.44830365
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.44155353
35STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.44029785
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43226198
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.43031352
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.42939356
39TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39037002
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37225160
41SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.33252870
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.31550322
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.31550322
44* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30374089
45RUNX_20019798_ChIP-Seq_JUKART_Human1.29859433
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.29549514
47* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25726675
48SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.24840809
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24699480
50SOX9_24532713_ChIP-Seq_HFSC_Mouse1.24570012
51MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23996804
52EP300_21415370_ChIP-Seq_HL-1_Mouse1.22002093
53* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21494408
54JARID2_20064375_ChIP-Seq_MESCs_Mouse1.19468158
55ESR1_21235772_ChIP-Seq_MCF-7_Human1.19236662
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18886697
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16907150
58FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.16223984
59VDR_24763502_ChIP-Seq_THP-1_Human1.16049039
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.15866283
61SOX2_20726797_ChIP-Seq_SW620_Human1.15530942
62DROSHA_22980978_ChIP-Seq_HELA_Human1.15281922
63* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14689992
64BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14359823
65PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13810867
66RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13214743
67NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12838116
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12456907
69PU_27001747_Chip-Seq_BMDM_Mouse1.10576915
70AR_21572438_ChIP-Seq_LNCaP_Human1.10376436
71CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09408159
72* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09103030
73BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08531932
74* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.07890952
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07612916
76EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07249323
77GATA1_19941826_ChIP-Seq_K562_Human1.07050161
78IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.06019628
79THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05996106
80PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05259984
81SCL_19346495_ChIP-Seq_HPC-7_Human1.03896623
82MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03632432
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.03060479
84JARID2_20075857_ChIP-Seq_MESCs_Mouse1.02903104
85SPI1_23127762_ChIP-Seq_K562_Human1.02323363
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02178148
87SPI1_23547873_ChIP-Seq_NB4_Human1.02141514
88EZH2_27304074_Chip-Seq_ESCs_Mouse1.01824693
89ESR1_20079471_ChIP-ChIP_T-47D_Human1.01402821
90* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00674988
91IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00515314
92RNF2_27304074_Chip-Seq_ESCs_Mouse1.00316614
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00298375
94GATA2_19941826_ChIP-Seq_K562_Human0.99217492
95* TP63_23658742_ChIP-Seq_EP156T_Human0.98949943
96RXR_22108803_ChIP-Seq_LS180_Human0.98211287
97AHR_22903824_ChIP-Seq_MCF-7_Human0.96327499
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95382568
99ARNT_22903824_ChIP-Seq_MCF-7_Human0.94763332
100* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94565427
101* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94333029
102PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93644583
103JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93450476
104CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91119997
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89644860
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89644860
107AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89289966
108* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89005334
109* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.88966016
110* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88775065
111LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88600156
112SUZ12_27294783_Chip-Seq_ESCs_Mouse0.88328824
113SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88232099
114* FOXO3_23340844_ChIP-Seq_DLD1_Human0.88223722
115TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87674190
116JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86401024
117STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86261020
118* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.85728066
119SMAD3_21741376_ChIP-Seq_HESCs_Human0.85639386
120* SMAD4_21799915_ChIP-Seq_A2780_Human0.84944035
121SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.84879361
122LXR_22158963_ChIP-Seq_LIVER_Mouse0.83933735
123GATA1_19941827_ChIP-Seq_MEL86_Mouse0.82165416
124TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.81740693
125SUZ12_27294783_Chip-Seq_NPCs_Mouse0.80225866
126* EZH2_27294783_Chip-Seq_ESCs_Mouse0.80138462
127RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.80122973
128SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79265862
129* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.78031736
130TAF15_26573619_Chip-Seq_HEK293_Human0.77673461
131POU3F2_20337985_ChIP-ChIP_501MEL_Human0.77096808
132SMRT_27268052_Chip-Seq_Bcells_Human0.76831803
133* RUNX1_22412390_ChIP-Seq_EML_Mouse0.76700650
134EZH2_27294783_Chip-Seq_NPCs_Mouse0.76665997
135CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.76655162
136PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.76086270
137* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.75133698
138GATA3_27048872_Chip-Seq_THYMUS_Human0.74910928
139NR3C1_23031785_ChIP-Seq_PC12_Mouse0.74883912
140KDM2B_26808549_Chip-Seq_SUP-B15_Human0.74721186
141RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74490277

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.20352181
2MP0005275_abnormal_skin_tensile3.71351207
3MP0006082_CNS_inflammation3.16001424
4MP0005058_abnormal_lysosome_morphology2.87330405
5MP0003303_peritoneal_inflammation2.56217074
6MP0001958_emphysema2.52631858
7MP0003279_aneurysm2.48152283
8MP0003690_abnormal_glial_cell2.40774215
9MP0003724_increased_susceptibility_to2.38283408
10MP0005503_abnormal_tendon_morphology2.32862055
11MP0000920_abnormal_myelination2.21995018
12MP0003191_abnormal_cellular_cholesterol2.21985909
13MP0002148_abnormal_hypersensitivity_rea2.20567525
14MP0002419_abnormal_innate_immunity2.06460391
15MP0001851_eye_inflammation2.01706857
16MP0003075_altered_response_to1.98587222
17MP0001835_abnormal_antigen_presentation1.93426820
18MP0001533_abnormal_skeleton_physiology1.91875898
19MP0004272_abnormal_basement_membrane1.82163743
20MP0005623_abnormal_meninges_morphology1.79543683
21MP0003436_decreased_susceptibility_to1.78244255
22MP0002998_abnormal_bone_remodeling1.74845069
23MP0003566_abnormal_cell_adhesion1.72930442
24MP0005000_abnormal_immune_tolerance1.69613772
25MP0005397_hematopoietic_system_phenotyp1.68250817
26MP0001545_abnormal_hematopoietic_system1.68250817
27MP0003941_abnormal_skin_development1.67647817
28MP0003045_fibrosis1.64997001
29MP0005671_abnormal_response_to1.58997559
30MP0003705_abnormal_hypodermis_morpholog1.55334142
31MP0003172_abnormal_lysosome_physiology1.53093328
32MP0005171_absent_coat_pigmentation1.52097659
33MP0002295_abnormal_pulmonary_circulatio1.51819779
34MP0003183_abnormal_peptide_metabolism1.51266325
35MP0005464_abnormal_platelet_physiology1.50672267
36MP0009384_cardiac_valve_regurgitation1.50368969
37MP0000343_altered_response_to1.49566451
38MP0005390_skeleton_phenotype1.47470168
39MP0005025_abnormal_response_to1.47414498
40MP0009840_abnormal_foam_cell1.44633350
41MP0005508_abnormal_skeleton_morphology1.42478137
42MP0005387_immune_system_phenotype1.41518949
43MP0001790_abnormal_immune_system1.41518949
44MP0009785_altered_susceptibility_to1.40640908
45MP0003329_amyloid_beta_deposits1.40428898
46MP0002060_abnormal_skin_morphology1.38082251
47MP0002452_abnormal_antigen_presenting1.36579153
48MP0008004_abnormal_stomach_pH1.35475080
49MP0000767_abnormal_smooth_muscle1.33769979
50MP0004947_skin_inflammation1.33514304
51MP0006054_spinal_hemorrhage1.33491794
52MP0003300_gastrointestinal_ulcer1.32838281
53MP0003136_yellow_coat_color1.30011263
54MP0005166_decreased_susceptibility_to1.27511383
55MP0002933_joint_inflammation1.26640016
56MP0001299_abnormal_eye_distance/1.24980955
57MP0001542_abnormal_bone_strength1.24851632
58MP0000685_abnormal_immune_system1.23307085
59MP0000465_gastrointestinal_hemorrhage1.20951583
60MP0005377_hearing/vestibular/ear_phenot1.18399381
61MP0003878_abnormal_ear_physiology1.18399381
62MP0000569_abnormal_digit_pigmentation1.16706609
63MP0003448_altered_tumor_morphology1.16205396
64MP0003828_pulmonary_edema1.15891086
65MP0002723_abnormal_immune_serum1.14739813
66MP0003195_calcinosis1.12430178
67MP0008260_abnormal_autophagy1.10168731
68MP0003453_abnormal_keratinocyte_physiol1.09987342
69MP0003091_abnormal_cell_migration1.09703903
70MP0005164_abnormal_response_to1.08343366
71MP0004185_abnormal_adipocyte_glucose1.06139647
72MP0005595_abnormal_vascular_smooth1.04614947
73MP0002796_impaired_skin_barrier1.04364560
74MP0008469_abnormal_protein_level1.02003997
75MP0004130_abnormal_muscle_cell1.01691909
76MP0005257_abnormal_intraocular_pressure0.99361389
77MP0002090_abnormal_vision0.99068339
78MP0001819_abnormal_immune_cell0.97756619
79MP0003634_abnormal_glial_cell0.96162248
80MP0005023_abnormal_wound_healing0.95976983
81MP0010155_abnormal_intestine_physiology0.94779321
82MP0005451_abnormal_body_composition0.94653873
83MP0002420_abnormal_adaptive_immunity0.94259882
84MP0004883_abnormal_blood_vessel0.93873976
85MP0002896_abnormal_bone_mineralization0.93409873
86MP0004510_myositis0.92046643
87MP0002168_other_aberrant_phenotype0.91721983
88MP0003632_abnormal_nervous_system0.91287361
89MP0002133_abnormal_respiratory_system0.90695577
90MP0005388_respiratory_system_phenotype0.90695577
91MP0001800_abnormal_humoral_immune0.90111273
92MP0005310_abnormal_salivary_gland0.89995332
93MP0001879_abnormal_lymphatic_vessel0.89729822
94MP0001853_heart_inflammation0.88835720
95MP0000733_abnormal_muscle_development0.87866035
96MP0003011_delayed_dark_adaptation0.87722215
97MP0005248_abnormal_Harderian_gland0.87571767
98MP0004484_altered_response_of0.87543026
99MP0002006_tumorigenesis0.86686601
100MP0000716_abnormal_immune_system0.86114231
101MP0010368_abnormal_lymphatic_system0.85191535
102MP0005409_darkened_coat_color0.85051294
103MP0002405_respiratory_system_inflammati0.84447849
104MP0005174_abnormal_tail_pigmentation0.83861006
105MP0010386_abnormal_urinary_bladder0.83772318
106MP0003950_abnormal_plasma_membrane0.83719092
107MP0001845_abnormal_inflammatory_respons0.82647960
108MP0010678_abnormal_skin_adnexa0.81463266
109MP0003795_abnormal_bone_structure0.79859512
110MP0005165_increased_susceptibility_to0.79821271
111MP0002115_abnormal_skeleton_extremities0.79432928
112MP0004134_abnormal_chest_morphology0.79054184
113MP0000383_abnormal_hair_follicle0.79047569
114MP0009250_abnormal_appendicular_skeleto0.78610154
115MP0000604_amyloidosis0.78262748
116MP0000249_abnormal_blood_vessel0.77905924
117MP0003385_abnormal_body_wall0.77835224
118MP0005167_abnormal_blood-brain_barrier0.76848225
119MP0010771_integument_phenotype0.75318881
120MP0009763_increased_sensitivity_to0.74670465
121MP0000858_altered_metastatic_potential0.71617106
122MP0005197_abnormal_uvea_morphology0.70903795
123MP0002282_abnormal_trachea_morphology0.70058039
124MP0003656_abnormal_erythrocyte_physiolo0.69416394
125MP0001216_abnormal_epidermal_layer0.68773542
126MP0009764_decreased_sensitivity_to0.68553829
127MP0000230_abnormal_systemic_arterial0.68290742
128MP0009278_abnormal_bone_marrow0.68230563
129MP0000689_abnormal_spleen_morphology0.66165103
130MP0005647_abnormal_sex_gland0.63760584
131MP0000015_abnormal_ear_pigmentation0.62896795

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)5.88017888
2Glomerulonephritis (HP:0000099)4.67373836
3Eczematoid dermatitis (HP:0000976)4.52963450
4Arterial tortuosity (HP:0005116)4.48861237
5Vascular tortuosity (HP:0004948)4.37548253
6Recurrent abscess formation (HP:0002722)4.13036915
7Premature rupture of membranes (HP:0001788)4.04420005
8Aortic dissection (HP:0002647)3.92084927
9Cerebral aneurysm (HP:0004944)3.80064353
10Recurrent bacterial skin infections (HP:0005406)3.76085230
11Increased cerebral lipofuscin (HP:0011813)3.57479176
12Protrusio acetabuli (HP:0003179)3.56340856
13Increased neuronal autofluorescent lipopigment (HP:0002074)3.50663551
14Abnormality of glycolipid metabolism (HP:0010969)3.50546686
15Abnormality of liposaccharide metabolism (HP:0010968)3.50546686
16Abnormality of glycosphingolipid metabolism (HP:0004343)3.50546686
17Aortic aneurysm (HP:0004942)3.47644304
18Shallow orbits (HP:0000586)3.34426036
19Dysostosis multiplex (HP:0000943)3.33665618
20Recurrent gram-negative bacterial infections (HP:0005420)3.32526481
21Vacuolated lymphocytes (HP:0001922)3.24866308
22Axonal loss (HP:0003447)3.22097238
23Mutism (HP:0002300)3.14811073
24Prolonged bleeding time (HP:0003010)3.12968571
25Broad metatarsal (HP:0001783)3.08264758
26Orchitis (HP:0100796)3.05410807
27Myositis (HP:0100614)2.95580691
28Optic neuritis (HP:0100653)2.91479538
29Retrobulbar optic neuritis (HP:0100654)2.91479538
30Abnormality of macrophages (HP:0004311)2.89699627
31Neurofibrillary tangles (HP:0002185)2.88982071
32Hematochezia (HP:0002573)2.88043110
33Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.87653651
34Purpura (HP:0000979)2.85155985
35Disinhibition (HP:0000734)2.84886628
36Spondylolisthesis (HP:0003302)2.84164921
37Myocardial infarction (HP:0001658)2.83866743
38Soft skin (HP:0000977)2.82648367
39Nephritis (HP:0000123)2.78967426
40Gingival bleeding (HP:0000225)2.78663072
41Peritonitis (HP:0002586)2.73117151
42Amyloidosis (HP:0011034)2.70093502
43Epistaxis (HP:0000421)2.61386741
44Vertebral compression fractures (HP:0002953)2.59217556
45Abnormality of the vasculature of the conjunctiva (HP:0008054)2.57860632
46Chronic mucocutaneous candidiasis (HP:0002728)2.52532808
47Recurrent cutaneous fungal infections (HP:0011370)2.52532808
48Atrophic scars (HP:0001075)2.52161738
49Parakeratosis (HP:0001036)2.51515681
50Hypoplasia of the iris (HP:0007676)2.51148576
51Recurrent fungal infections (HP:0002841)2.50406362
52Disproportionate tall stature (HP:0001519)2.48287621
53Mitral valve prolapse (HP:0001634)2.40936870
54Osteolytic defects of the phalanges of the hand (HP:0009771)2.40700704
55Osteolytic defects of the hand bones (HP:0009699)2.40700704
56Absent frontal sinuses (HP:0002688)2.40349504
57Keratoconjunctivitis sicca (HP:0001097)2.32645208
58Recurrent skin infections (HP:0001581)2.30642660
59Gingivitis (HP:0000230)2.27412771
60Autoimmune thrombocytopenia (HP:0001973)2.26749470
61Complement deficiency (HP:0004431)2.26279874
62Hemoptysis (HP:0002105)2.26069465
63Mucopolysacchariduria (HP:0008155)2.20686679
64Urinary glycosaminoglycan excretion (HP:0003541)2.20686679
65Abnormality of complement system (HP:0005339)2.20440228
66Segmental peripheral demyelination/remyelination (HP:0003481)2.20344998
67Thick nail (HP:0001805)2.19803713
68Abnormality of the lumbar spine (HP:0100712)2.17169918
69Dilatation of the ascending aorta (HP:0005111)2.15836875
70Abnormality of secondary sexual hair (HP:0009888)2.14226342
71Abnormality of the axillary hair (HP:0100134)2.14226342
72Petechiae (HP:0000967)2.12292344
73Mediastinal lymphadenopathy (HP:0100721)2.11419788
74Abnormality of the periventricular white matter (HP:0002518)2.10755246
75Keratoconjunctivitis (HP:0001096)2.07954593
76Pulmonary infiltrates (HP:0002113)2.07314790
77Abnormality of mucopolysaccharide metabolism (HP:0011020)2.06839363
78Abnormality of polysaccharide metabolism (HP:0011012)2.06839363
79Abnormality of glycosaminoglycan metabolism (HP:0004371)2.06839363
80Striae distensae (HP:0001065)2.04744793
81Increased IgE level (HP:0003212)2.03960434
82Pulmonary artery stenosis (HP:0004415)2.01451365
83Gastrointestinal infarctions (HP:0005244)1.99258829
84Asymmetric septal hypertrophy (HP:0001670)1.97807813
85Increased CSF protein (HP:0002922)1.97459525
86Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.96635532
87Urticaria (HP:0001025)1.96283108
88T lymphocytopenia (HP:0005403)1.96141263
89Camptodactyly of toe (HP:0001836)1.95842968
90J-shaped sella turcica (HP:0002680)1.95018275
91Agnosia (HP:0010524)1.94106530
92Retinal atrophy (HP:0001105)1.93738176
93Follicular hyperkeratosis (HP:0007502)1.93199318
94Arnold-Chiari malformation (HP:0002308)1.93165370
95Conjunctival telangiectasia (HP:0000524)1.92560107
96Arterial thrombosis (HP:0004420)1.92381801
97Abnormal platelet volume (HP:0011876)1.92118741
98Vertigo (HP:0002321)1.90975093
99Loss of speech (HP:0002371)1.90520754
100Cellulitis (HP:0100658)1.90023056
101Inappropriate behavior (HP:0000719)1.90018372
102Osteomyelitis (HP:0002754)1.89761982
103Hepatosplenomegaly (HP:0001433)1.88079903
104Stomatitis (HP:0010280)1.86833705
105Neuronal loss in central nervous system (HP:0002529)1.84849317
106Metaphyseal cupping (HP:0003021)1.84361077
107Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.84294288
108Cervical subluxation (HP:0003308)1.82768639
109Abnormality of T cell number (HP:0011839)1.81729163
110Chest pain (HP:0100749)1.80953632
111Hyperextensible skin (HP:0000974)1.80826839
112Cerebral inclusion bodies (HP:0100314)1.80551530
113Joint stiffness (HP:0001387)1.80077859
114Progressive visual loss (HP:0000529)1.79995299
115Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.79376607
116Chronic obstructive pulmonary disease (HP:0006510)1.78278358
117Obstructive lung disease (HP:0006536)1.78278358
118Mitral stenosis (HP:0001718)1.77982705
119Leukocytosis (HP:0001974)1.77609803
120Meningitis (HP:0001287)1.77254300
121Increased mean platelet volume (HP:0011877)1.76414380
122Periodontitis (HP:0000704)1.76277455
123Broad ribs (HP:0000885)1.76211839
124Wormian bones (HP:0002645)1.75725099
125Urethral obstruction (HP:0000796)1.75651091
126Pulmonary embolism (HP:0002204)1.75488832
127Blue sclerae (HP:0000592)1.75354772
128Interstitial pulmonary disease (HP:0006530)1.75208886
129Clumsiness (HP:0002312)1.74424793
130Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.72446547
131Elevated erythrocyte sedimentation rate (HP:0003565)1.71808714
132Metaphyseal dysplasia (HP:0100255)1.70986093
133Spontaneous hematomas (HP:0007420)1.70686872
134Global brain atrophy (HP:0002283)1.70604640
135Prostate neoplasm (HP:0100787)1.70188950
136Bladder diverticulum (HP:0000015)1.69370311
137Pathologic fracture (HP:0002756)1.68484071
138Craniofacial hyperostosis (HP:0004493)1.68337385
139Thin bony cortex (HP:0002753)1.66645505
140Femoral bowing (HP:0002980)1.66071555
141Premature skin wrinkling (HP:0100678)1.65331956
142Round ear (HP:0100830)1.64720031
143Fragile skin (HP:0001030)1.64338451
144Coronal craniosynostosis (HP:0004440)1.60788830
145Onion bulb formation (HP:0003383)1.58011037
146Scapular winging (HP:0003691)1.57138045
147Supranuclear gaze palsy (HP:0000605)1.56604508
148Basal ganglia calcification (HP:0002135)1.56208851
149Obstructive sleep apnea (HP:0002870)1.55907162
150Corneal dystrophy (HP:0001131)1.55875474
151Abnormality of the peritoneum (HP:0002585)1.54796158
152Mitral regurgitation (HP:0001653)1.54397072

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR25.24354768
2RIPK43.79586371
3BLK2.71212200
4GRK72.57685547
5EPHB12.46125407
6STK392.38543459
7MAPK152.29925650
8CAMK1D1.82584843
9OXSR11.75912562
10TAOK31.73633414
11EPHB21.73582767
12CSF1R1.68235166
13MAPKAPK51.66161954
14PBK1.60512689
15STK101.56687867
16CLK11.55881593
17MAP2K31.55850083
18MAP3K141.52406768
19DMPK1.50540683
20SYK1.49064708
21CAMK1G1.47995032
22TYK21.46496838
23SGK21.43771195
24IRAK41.40979583
25MST1R1.40843453
26TRPM71.38284141
27ACVR1B1.38222292
28IRAK31.36878410
29WNK11.36602278
30KIT1.34401825
31TBK11.28526226
32PIM21.27767381
33JAK11.27564993
34FGR1.26731914
35BTK1.26308167
36TEC1.26143561
37NEK91.23657322
38IKBKB1.22844268
39DDR21.22087094
40HCK1.16498169
41PKN11.13398543
42MAP3K61.11724859
43TNK21.10204567
44MAP3K131.09325813
45SGK31.08354063
46MET1.08308174
47CSK1.07800637
48MARK31.07017529
49WNK41.06810110
50EPHA31.06201208
51CDC42BPA1.05297820
52NLK1.02613915
53MAP3K21.01256355
54MAP3K31.01114245
55MAP3K10.96751275
56MARK20.93103195
57TXK0.89316046
58ERN10.89273134
59MOS0.88887420
60BMPR20.88376993
61YES10.86946292
62FRK0.86423130
63ADRBK20.86290649
64BMX0.85564475
65MATK0.85278890
66PDGFRB0.82716858
67PRKD10.82360938
68CDK60.82359903
69FGFR20.81809125
70MAP4K10.81718608
71MST40.80911991
72NEK60.80761974
73NTRK10.79796279
74IRAK10.79032308
75PDK10.78553473
76SGK4940.76292966
77SGK2230.76292966
78LCK0.75958616
79PRKCH0.75049072
80TTN0.71353382
81RET0.71081172
82ITK0.70570684
83JAK20.67198346
84PIK3CA0.66544415
85TNIK0.65856369
86IRAK20.65666862
87STK240.64421718
88ERBB20.64344485
89PAK20.64305795
90GSK3A0.64081888
91RPS6KA20.63507423
92LYN0.63266957
93PRKCE0.63220745
94CAMKK20.63100768
95DAPK20.62661207
96ABL10.61944831
97MAP3K50.61938153
98PAK40.61912679
99MAPK70.60892031
100JAK30.60667759
101IGF1R0.60395245
102GRK60.60385598
103MAP3K110.60065267
104PRPF4B0.59793712
105LIMK10.59504803
106PDPK10.59381148
107ZAP700.59371611
108PDGFRA0.59312497
109FYN0.58816253
110GRK50.58566460
111ABL20.58480158
112MAPK120.58364867
113MAPKAPK20.57479617
114IKBKE0.56522512
115MAP2K40.56459589
116EIF2AK20.54274651
117FER0.53646996
118PRKAA20.53637511
119RIPK10.53634532
120ROCK20.53558654
121CAMK40.53174024
122INSR0.53155185
123MYLK0.52704955
124RPS6KL10.51367850
125RPS6KC10.51367850
126FGFR30.48691138
127EGFR0.48522267
128MAP3K70.48441628
129PIK3CG0.47667360
130TAOK10.46257507
131STK110.46217423
132PINK10.45848726
133RPS6KA60.45671437
134MAPK40.45418991
135AKT30.44864029
136SRC0.44190921
137PTK2B0.43337423
138CDK30.43034223
139TIE10.42953658
140PAK30.42859227
141FES0.42172087
142DAPK30.40800037
143BCR0.39918219
144ERBB30.39692784

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.93994612
2Other glycan degradation_Homo sapiens_hsa005112.29516017
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.16263588
4Pertussis_Homo sapiens_hsa051332.14501399
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.09115094
6Malaria_Homo sapiens_hsa051442.08573688
7Leishmaniasis_Homo sapiens_hsa051402.08049928
8Lysosome_Homo sapiens_hsa041422.05165971
9Osteoclast differentiation_Homo sapiens_hsa043801.88273581
10Rheumatoid arthritis_Homo sapiens_hsa053231.70377805
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.56284822
12Phagosome_Homo sapiens_hsa041451.56116164
13Tuberculosis_Homo sapiens_hsa051521.54063730
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.52588341
15ECM-receptor interaction_Homo sapiens_hsa045121.52385156
16Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.45853617
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.42405903
18Salmonella infection_Homo sapiens_hsa051321.40417177
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37680979
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.31944495
21Graft-versus-host disease_Homo sapiens_hsa053321.29747407
22Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.28036320
23Amoebiasis_Homo sapiens_hsa051461.27331622
24Prion diseases_Homo sapiens_hsa050201.23821833
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.22525554
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22423151
27Toxoplasmosis_Homo sapiens_hsa051451.19442313
28Chemokine signaling pathway_Homo sapiens_hsa040621.17525785
29Platelet activation_Homo sapiens_hsa046111.14337221
30Sphingolipid metabolism_Homo sapiens_hsa006001.13614578
31Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.12854503
32B cell receptor signaling pathway_Homo sapiens_hsa046621.11493363
33Focal adhesion_Homo sapiens_hsa045101.08463489
34Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.08236602
35Hematopoietic cell lineage_Homo sapiens_hsa046401.07212711
36Regulation of actin cytoskeleton_Homo sapiens_hsa048101.06003828
37Ether lipid metabolism_Homo sapiens_hsa005651.04264618
38Antigen processing and presentation_Homo sapiens_hsa046121.04088669
39Legionellosis_Homo sapiens_hsa051341.01481891
40Allograft rejection_Homo sapiens_hsa053301.00567502
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99799494
42TNF signaling pathway_Homo sapiens_hsa046680.99747325
43African trypanosomiasis_Homo sapiens_hsa051430.98950389
44NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98337012
45Sphingolipid signaling pathway_Homo sapiens_hsa040710.97755951
46Axon guidance_Homo sapiens_hsa043600.97235795
47Arachidonic acid metabolism_Homo sapiens_hsa005900.96266768
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94890259
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94700003
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.93347132
51Renal cell carcinoma_Homo sapiens_hsa052110.91662869
52Jak-STAT signaling pathway_Homo sapiens_hsa046300.89946710
53Endocytosis_Homo sapiens_hsa041440.89202353
54Proteoglycans in cancer_Homo sapiens_hsa052050.87820532
55Shigellosis_Homo sapiens_hsa051310.86356476
56Rap1 signaling pathway_Homo sapiens_hsa040150.84153689
57Measles_Homo sapiens_hsa051620.82339183
58Adherens junction_Homo sapiens_hsa045200.81831401
59Pancreatic cancer_Homo sapiens_hsa052120.81455923
60Asthma_Homo sapiens_hsa053100.77116779
61Acute myeloid leukemia_Homo sapiens_hsa052210.75732214
62Complement and coagulation cascades_Homo sapiens_hsa046100.74219889
63GnRH signaling pathway_Homo sapiens_hsa049120.73706245
64Autoimmune thyroid disease_Homo sapiens_hsa053200.73295151
65Renin secretion_Homo sapiens_hsa049240.72952556
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.72188449
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70850809
68Chronic myeloid leukemia_Homo sapiens_hsa052200.70697540
69Influenza A_Homo sapiens_hsa051640.70426939
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70332607
71Ovarian steroidogenesis_Homo sapiens_hsa049130.69812359
72TGF-beta signaling pathway_Homo sapiens_hsa043500.69322259
73Ras signaling pathway_Homo sapiens_hsa040140.69200131
74Protein digestion and absorption_Homo sapiens_hsa049740.68833207
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68005399
76Dorso-ventral axis formation_Homo sapiens_hsa043200.67320796
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.66765558
78Viral myocarditis_Homo sapiens_hsa054160.65619358
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.64561673
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64162924
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62942314
82Dilated cardiomyopathy_Homo sapiens_hsa054140.62573814
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61701913
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60766773
85Prolactin signaling pathway_Homo sapiens_hsa049170.60744797
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60143971
87Steroid biosynthesis_Homo sapiens_hsa001000.59870653
88Choline metabolism in cancer_Homo sapiens_hsa052310.59769626
89PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58828523
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58127071
91Nitrogen metabolism_Homo sapiens_hsa009100.57087638
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56150643
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.56032842
94Collecting duct acid secretion_Homo sapiens_hsa049660.56030797
95Hepatitis B_Homo sapiens_hsa051610.55799432
96Serotonergic synapse_Homo sapiens_hsa047260.55634357
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55091503
98Notch signaling pathway_Homo sapiens_hsa043300.55062748
99Apoptosis_Homo sapiens_hsa042100.54716351
100Gastric acid secretion_Homo sapiens_hsa049710.53868277
101T cell receptor signaling pathway_Homo sapiens_hsa046600.53687937
102Estrogen signaling pathway_Homo sapiens_hsa049150.53677662
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.52731186
104Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52143174
105Glioma_Homo sapiens_hsa052140.51493199
106MAPK signaling pathway_Homo sapiens_hsa040100.50336629
107ErbB signaling pathway_Homo sapiens_hsa040120.50302896
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49978819
109Mineral absorption_Homo sapiens_hsa049780.49846582
110Melanoma_Homo sapiens_hsa052180.49259938
111Hepatitis C_Homo sapiens_hsa051600.48738008
112VEGF signaling pathway_Homo sapiens_hsa043700.48626462
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48317192
114Gap junction_Homo sapiens_hsa045400.48206681
115Pathways in cancer_Homo sapiens_hsa052000.47922969
116Type I diabetes mellitus_Homo sapiens_hsa049400.47866295
117Long-term depression_Homo sapiens_hsa047300.47272139
118Inositol phosphate metabolism_Homo sapiens_hsa005620.46957525
119Oxytocin signaling pathway_Homo sapiens_hsa049210.46188940
120Salivary secretion_Homo sapiens_hsa049700.44761518
121HIF-1 signaling pathway_Homo sapiens_hsa040660.44553186
122Non-small cell lung cancer_Homo sapiens_hsa052230.44251517
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.43825081
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43566358
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.43429606
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41374372

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