PLXNA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)4.77054853
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.61339531
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.55158874
4neuron cell-cell adhesion (GO:0007158)4.50223937
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.46484968
6layer formation in cerebral cortex (GO:0021819)4.31227976
7protein localization to synapse (GO:0035418)4.28281609
8neuron recognition (GO:0008038)4.20496718
9locomotory exploration behavior (GO:0035641)4.13192972
10ionotropic glutamate receptor signaling pathway (GO:0035235)4.12861225
11regulation of glutamate receptor signaling pathway (GO:1900449)4.09754728
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.02925812
13axonal fasciculation (GO:0007413)4.02132700
14lymphangiogenesis (GO:0001946)3.88728278
15dendritic spine morphogenesis (GO:0060997)3.85714923
16synaptic vesicle maturation (GO:0016188)3.83915793
17glutamate receptor signaling pathway (GO:0007215)3.77345210
18synaptic vesicle exocytosis (GO:0016079)3.73478799
19postsynaptic membrane organization (GO:0001941)3.68215518
20establishment of mitochondrion localization (GO:0051654)3.63215552
21glutamate secretion (GO:0014047)3.62124169
22regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.61604056
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.60597678
24dendrite morphogenesis (GO:0048813)3.56888182
25exploration behavior (GO:0035640)3.50324968
26presynaptic membrane assembly (GO:0097105)3.49373909
27synaptic transmission, glutamatergic (GO:0035249)3.47107954
28regulation of axon guidance (GO:1902667)3.43745867
29central nervous system projection neuron axonogenesis (GO:0021952)3.42307976
30regulation of synaptic vesicle exocytosis (GO:2000300)3.41217464
31neurotransmitter-gated ion channel clustering (GO:0072578)3.41146184
32synaptic vesicle docking involved in exocytosis (GO:0016081)3.38355123
33regulation of dendritic spine morphogenesis (GO:0061001)3.34213694
34regulation of long-term neuronal synaptic plasticity (GO:0048169)3.33313500
35establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.31606950
36mitochondrion transport along microtubule (GO:0047497)3.31606950
37neuron-neuron synaptic transmission (GO:0007270)3.29367051
38regulation of neuronal synaptic plasticity (GO:0048168)3.25786718
39presynaptic membrane organization (GO:0097090)3.23339085
40pyrimidine nucleobase catabolic process (GO:0006208)3.22619975
41membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.21900618
42regulation of synapse structural plasticity (GO:0051823)3.20463065
43regulation of excitatory postsynaptic membrane potential (GO:0060079)3.16800825
44regulation of postsynaptic membrane potential (GO:0060078)3.13122739
45neuronal action potential propagation (GO:0019227)3.09873445
46positive regulation of synapse maturation (GO:0090129)3.09097146
47cerebral cortex radially oriented cell migration (GO:0021799)3.06610784
48neurotransmitter secretion (GO:0007269)3.02303631
49cardiac ventricle formation (GO:0003211)3.00590526
50gamma-aminobutyric acid transport (GO:0015812)2.99814595
51regulation of synaptic vesicle transport (GO:1902803)2.97782941
52cytoskeletal anchoring at plasma membrane (GO:0007016)2.97081541
53long-term memory (GO:0007616)2.95658905
54transmission of nerve impulse (GO:0019226)2.95573834
55cerebellar Purkinje cell differentiation (GO:0021702)2.94875234
56positive regulation of membrane potential (GO:0045838)2.93920562
57regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.90712522
58regulation of dendritic spine development (GO:0060998)2.89684380
59innervation (GO:0060384)2.89211681
60cardiac chamber formation (GO:0003207)2.87458981
61positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.87442355
62nucleobase catabolic process (GO:0046113)2.86784661
63positive regulation of dendritic spine morphogenesis (GO:0061003)2.86358879
64proline transport (GO:0015824)2.86284205
65regulation of synaptic transmission, glutamatergic (GO:0051966)2.86090406
66G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.85206755
67synapse assembly (GO:0007416)2.83949993
68auditory behavior (GO:0031223)2.83924045
69central nervous system neuron axonogenesis (GO:0021955)2.77611775
70gamma-aminobutyric acid signaling pathway (GO:0007214)2.75135309
71* cell migration in hindbrain (GO:0021535)2.75080091
72axon extension (GO:0048675)2.73734976
73dendritic spine organization (GO:0097061)2.73439499
74positive regulation of dendritic spine development (GO:0060999)2.73016122
75negative regulation of synaptic transmission, GABAergic (GO:0032229)2.72960845
76synaptic vesicle endocytosis (GO:0048488)2.72911207
77regulation of synapse maturation (GO:0090128)2.72206394
78startle response (GO:0001964)2.71669864
79membrane hyperpolarization (GO:0060081)2.71341383
80positive regulation of synaptic transmission, GABAergic (GO:0032230)2.71010317
81neuron remodeling (GO:0016322)2.68356503
82membrane depolarization (GO:0051899)2.67141202
83regulation of synaptic plasticity (GO:0048167)2.67124815
84artery development (GO:0060840)2.66932995
85neuronal ion channel clustering (GO:0045161)2.66505569
86synapse organization (GO:0050808)2.65850947
87membrane depolarization during action potential (GO:0086010)2.65463307
88response to auditory stimulus (GO:0010996)2.65327118
89positive regulation of synapse assembly (GO:0051965)2.64533297
90retina vasculature morphogenesis in camera-type eye (GO:0061299)2.64318458
91negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.62091797
92regulation of vesicle fusion (GO:0031338)2.61878203
93wound healing, spreading of epidermal cells (GO:0035313)2.60201273
94G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.59966070
95activation of protein kinase A activity (GO:0034199)2.59641702
96cerebellar granule cell differentiation (GO:0021707)2.59423300
97cellular potassium ion homeostasis (GO:0030007)2.59238549
98positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.59134923
99behavioral defense response (GO:0002209)2.58320415
100behavioral fear response (GO:0001662)2.58320415
101regulation of axon extension involved in axon guidance (GO:0048841)2.57767671
102cell communication by electrical coupling (GO:0010644)2.57457788
103suckling behavior (GO:0001967)2.57317315
104neuromuscular process controlling balance (GO:0050885)2.57191928
105regulation of neurotransmitter secretion (GO:0046928)2.56569053
106membrane assembly (GO:0071709)2.56094559
107blood vessel maturation (GO:0001955)2.55866687
108cochlea development (GO:0090102)2.55434150
109establishment of nucleus localization (GO:0040023)2.54898223
110endothelium development (GO:0003158)2.54094933
111long-term synaptic potentiation (GO:0060291)2.53252966
112neuron projection extension involved in neuron projection guidance (GO:1902284)2.53017979
113axon extension involved in axon guidance (GO:0048846)2.53017979
114negative regulation of dendrite development (GO:2000171)2.52829423
115learning (GO:0007612)2.52483579
116lens morphogenesis in camera-type eye (GO:0002089)2.52368478
117cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.52338413
118homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.52260593
119neurotransmitter transport (GO:0006836)2.52219743
120regulation of synapse assembly (GO:0051963)2.50686892
121calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.49383163
122endothelial cell differentiation (GO:0045446)2.47578598
123* semaphorin-plexin signaling pathway (GO:0071526)2.44039404
124mating behavior (GO:0007617)2.39796681
125apical protein localization (GO:0045176)2.38527937
126neuron projection extension (GO:1990138)2.36425623
127sodium ion export (GO:0071436)2.34247683
128negative regulation of axon extension involved in axon guidance (GO:0048843)2.32546968
129positive regulation of dendrite development (GO:1900006)2.30841903
130coronary vasculature morphogenesis (GO:0060977)2.30838841
131glial cell proliferation (GO:0014009)2.29303508
132sympathetic nervous system development (GO:0048485)2.29112586
133ganglion development (GO:0061548)2.28823826
134regulation of synapse organization (GO:0050807)2.28450143
135hemidesmosome assembly (GO:0031581)2.27611088
136negative regulation of dendrite morphogenesis (GO:0050774)2.27590816
137organelle transport along microtubule (GO:0072384)2.26889565
138positive regulation of axon extension (GO:0045773)2.24599939
139spinal cord development (GO:0021510)2.21947697
140negative chemotaxis (GO:0050919)2.21841641
141Notch signaling involved in heart development (GO:0061314)2.21664527
142neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.20514281
143negative regulation of axon extension (GO:0030517)2.20126497
144vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.20077746
145ephrin receptor signaling pathway (GO:0048013)2.19798166
146dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.19503953

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.13738467
2GBX2_23144817_ChIP-Seq_PC3_Human3.55487199
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.78566031
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.76977101
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.72831909
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51535957
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51535957
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.48852036
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39403762
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37840120
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37333505
12* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29339753
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.29109448
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.24060322
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20905746
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.18684471
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.12187453
18DROSHA_22980978_ChIP-Seq_HELA_Human2.09721205
19* RNF2_27304074_Chip-Seq_ESCs_Mouse2.04786083
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.04060477
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01816680
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.01287445
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.98556804
24REST_21632747_ChIP-Seq_MESCs_Mouse1.97406329
25AR_21572438_ChIP-Seq_LNCaP_Human1.90132084
26* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77066250
27* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.76948470
28TAF15_26573619_Chip-Seq_HEK293_Human1.74813602
29* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71439964
30* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68076291
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66716000
32* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63426241
33* RARB_27405468_Chip-Seq_BRAIN_Mouse1.62730477
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.62213286
35* SMAD4_21799915_ChIP-Seq_A2780_Human1.62025909
36TP63_17297297_ChIP-ChIP_HaCaT_Human1.56476610
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54847719
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54843025
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54492192
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.52203410
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51185490
42* P300_19829295_ChIP-Seq_ESCs_Human1.50884914
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.50149263
44SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.49750134
45ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46932986
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.46410037
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44552332
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43247805
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42533339
50* REST_18959480_ChIP-ChIP_MESCs_Mouse1.41973457
51IGF1R_20145208_ChIP-Seq_DFB_Human1.41487869
52AHR_22903824_ChIP-Seq_MCF-7_Human1.37287969
53ARNT_22903824_ChIP-Seq_MCF-7_Human1.36549715
54GATA2_21666600_ChIP-Seq_HMVEC_Human1.36255298
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.35133412
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34855993
57ZNF274_21170338_ChIP-Seq_K562_Hela1.34282946
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32952944
59EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31807653
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31575361
61BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30180494
62* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28252912
63* SOX2_21211035_ChIP-Seq_LN229_Gbm1.28175203
64* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28141455
65* STAT3_23295773_ChIP-Seq_U87_Human1.27151852
66* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26122031
67TP53_16413492_ChIP-PET_HCT116_Human1.25073322
68* RING1B_27294783_Chip-Seq_ESCs_Mouse1.24455203
69AR_25329375_ChIP-Seq_VCAP_Human1.23241661
70CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22557181
71* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21901898
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.19739064
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19350500
74IKZF1_21737484_ChIP-ChIP_HCT116_Human1.18635923
75* RING1B_27294783_Chip-Seq_NPCs_Mouse1.17983431
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17508270
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17508270
78* AR_19668381_ChIP-Seq_PC3_Human1.17321273
79* TP53_18474530_ChIP-ChIP_U2OS_Human1.16240208
80* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15424528
81ISL1_27105846_Chip-Seq_CPCs_Mouse1.15114660
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14242468
83RNF2_27304074_Chip-Seq_NSC_Mouse1.14135732
84KDM2B_26808549_Chip-Seq_K562_Human1.13212961
85* TCF4_23295773_ChIP-Seq_U87_Human1.12644378
86* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12035966
87* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.11666612
88WT1_19549856_ChIP-ChIP_CCG9911_Human1.11276696
89ERG_21242973_ChIP-ChIP_JURKAT_Human1.10898364
90FUS_26573619_Chip-Seq_HEK293_Human1.10330603
91ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09865216
92* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09654816
93EP300_21415370_ChIP-Seq_HL-1_Mouse1.08952548
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08492951
95* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08483493
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07589755
97* RUNX2_22187159_ChIP-Seq_PCA_Human1.07277087
98BCAT_22108803_ChIP-Seq_LS180_Human1.06752865
99* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06451694
100* SMAD3_21741376_ChIP-Seq_HESCs_Human1.03275955
101MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02781901
102TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02402846
103* SMAD4_21741376_ChIP-Seq_HESCs_Human1.02198904
104TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02143344
105* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01887348
106* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01887348
107LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00805163
108* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00529730
109* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00008045
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99988961
111P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99801941
112RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99583220
113* NANOG_18555785_Chip-Seq_ESCs_Mouse0.98834851
114CDX2_20551321_ChIP-Seq_CACO-2_Human0.98081029
115ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97194099
116VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96406291
117VDR_22108803_ChIP-Seq_LS180_Human0.96106913
118CJUN_26792858_Chip-Seq_BT549_Human0.95744910
119CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95694962
120* TCF4_18268006_ChIP-ChIP_LS174T_Human0.94063245
121ER_23166858_ChIP-Seq_MCF-7_Human0.93114616
122* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92759249
123MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91996407
124RXR_22108803_ChIP-Seq_LS180_Human0.91803753
125* PRDM14_20953172_ChIP-Seq_ESCs_Human0.90439488
126KDM2B_26808549_Chip-Seq_REH_Human0.90216188
127* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89666623
128* SMAD3_21741376_ChIP-Seq_ESCs_Human0.89364043

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.21410840
2MP0003880_abnormal_central_pattern4.37033726
3MP0010368_abnormal_lymphatic_system3.86525084
4MP0004270_analgesia3.65368000
5MP0003635_abnormal_synaptic_transmissio3.47426262
6MP0002063_abnormal_learning/memory/cond2.85332019
7MP0009745_abnormal_behavioral_response2.71845637
8MP0005423_abnormal_somatic_nervous2.64668243
9MP0000778_abnormal_nervous_system2.53421726
10MP0009046_muscle_twitch2.50226590
11MP0004272_abnormal_basement_membrane2.47092089
12MP0001486_abnormal_startle_reflex2.44031822
13MP0001879_abnormal_lymphatic_vessel2.43656276
14MP0002064_seizures2.41293902
15MP0002734_abnormal_mechanical_nocicepti2.38027465
16MP0002572_abnormal_emotion/affect_behav2.36858425
17MP0001968_abnormal_touch/_nociception2.32544768
18MP0009780_abnormal_chondrocyte_physiolo2.31602669
19MP0002735_abnormal_chemical_nociception2.23714538
20MP0000569_abnormal_digit_pigmentation2.14396907
21MP0002272_abnormal_nervous_system1.96539101
22MP0002184_abnormal_innervation1.92847137
23MP0001440_abnormal_grooming_behavior1.85663112
24MP0001188_hyperpigmentation1.80076564
25MP0002822_catalepsy1.77267510
26MP0002067_abnormal_sensory_capabilities1.74514136
27MP0002733_abnormal_thermal_nociception1.73197883
28MP0002557_abnormal_social/conspecific_i1.67011213
29MP0001501_abnormal_sleep_pattern1.64990934
30MP0002736_abnormal_nociception_after1.63573525
31MP0003787_abnormal_imprinting1.60904313
32MP0006276_abnormal_autonomic_nervous1.59803655
33MP0001970_abnormal_pain_threshold1.58988815
34MP0004858_abnormal_nervous_system1.58753090
35MP0005551_abnormal_eye_electrophysiolog1.58572632
36MP0004924_abnormal_behavior1.51631075
37MP0005386_behavior/neurological_phenoty1.51631075
38MP0000955_abnormal_spinal_cord1.49366120
39MP0002882_abnormal_neuron_morphology1.46685322
40* MP0004811_abnormal_neuron_physiology1.46303114
41MP0003705_abnormal_hypodermis_morpholog1.42015274
42MP0000751_myopathy1.35043797
43MP0008569_lethality_at_weaning1.33956974
44MP0002837_dystrophic_cardiac_calcinosis1.33397092
45MP0003279_aneurysm1.32563795
46MP0001984_abnormal_olfaction1.32103533
47MP0008438_abnormal_cutaneous_collagen1.31195892
48MP0005409_darkened_coat_color1.28844381
49MP0005257_abnormal_intraocular_pressure1.24685518
50MP0001958_emphysema1.23278291
51MP0004885_abnormal_endolymph1.23158217
52MP0005367_renal/urinary_system_phenotyp1.21122852
53MP0000516_abnormal_urinary_system1.21122852
54MP0002234_abnormal_pharynx_morphology1.19917241
55MP0005670_abnormal_white_adipose1.18518293
56* MP0002066_abnormal_motor_capabilities/c1.18333318
57MP0010030_abnormal_orbit_morphology1.15349851
58MP0005645_abnormal_hypothalamus_physiol1.14741961
59MP0003329_amyloid_beta_deposits1.14335629
60* MP0002152_abnormal_brain_morphology1.13725213
61MP0001502_abnormal_circadian_rhythm1.13342714
62MP0003283_abnormal_digestive_organ1.12652416
63MP0005646_abnormal_pituitary_gland1.12562114
64MP0002909_abnormal_adrenal_gland1.12440250
65MP0004215_abnormal_myocardial_fiber1.10171077
66MP0003868_abnormal_feces_composition1.09271438
67MP0004145_abnormal_muscle_electrophysio1.07637252
68MP0004085_abnormal_heartbeat1.07032494
69MP0003935_abnormal_craniofacial_develop1.04737168
70MP0005187_abnormal_penis_morphology1.03723963
71MP0000631_abnormal_neuroendocrine_gland1.03636734
72MP0000537_abnormal_urethra_morphology1.03280921
73MP0004742_abnormal_vestibular_system1.03040197
74MP0006072_abnormal_retinal_apoptosis1.02866273
75MP0002752_abnormal_somatic_nervous1.02525495
76MP0000049_abnormal_middle_ear1.01159094
77MP0003879_abnormal_hair_cell1.00860353
78MP0001177_atelectasis1.00789280
79MP0002638_abnormal_pupillary_reflex1.00302638
80MP0003633_abnormal_nervous_system0.97501214
81MP0000762_abnormal_tongue_morphology0.96808403
82MP0002102_abnormal_ear_morphology0.96546431
83MP0006138_congestive_heart_failure0.95535691
84MP0005275_abnormal_skin_tensile0.95152488
85MP0005595_abnormal_vascular_smooth0.92385279
86MP0006292_abnormal_olfactory_placode0.92192718
87MP0003137_abnormal_impulse_conducting0.91597965
88MP0010386_abnormal_urinary_bladder0.91251100
89MP0001299_abnormal_eye_distance/0.89006919
90MP0002229_neurodegeneration0.88716881
91MP0004133_heterotaxia0.88458997
92MP0004782_abnormal_surfactant_physiolog0.88103325
93MP0000013_abnormal_adipose_tissue0.87163119
94MP0004142_abnormal_muscle_tone0.86212543
95MP0003631_nervous_system_phenotype0.85856007
96MP0005623_abnormal_meninges_morphology0.85489030
97MP0000767_abnormal_smooth_muscle0.85429592
98MP0003122_maternal_imprinting0.84610553
99MP0005253_abnormal_eye_physiology0.83575039
100MP0005394_taste/olfaction_phenotype0.82979898
101MP0005499_abnormal_olfactory_system0.82979898
102MP0003385_abnormal_body_wall0.82558625
103MP0003861_abnormal_nervous_system0.82377492
104MP0003755_abnormal_palate_morphology0.82044775
105MP0005248_abnormal_Harderian_gland0.80960185
106MP0001529_abnormal_vocalization0.80708395
107MP0004484_altered_response_of0.79478419
108MP0002069_abnormal_eating/drinking_beha0.79068111
109MP0003566_abnormal_cell_adhesion0.79030872
110MP0001963_abnormal_hearing_physiology0.77224208
111MP0002127_abnormal_cardiovascular_syste0.77206500
112MP0005195_abnormal_posterior_eye0.76717417
113MP0001943_abnormal_respiration0.76339329
114MP0003938_abnormal_ear_development0.75952362
115MP0002925_abnormal_cardiovascular_devel0.75826281
116MP0003634_abnormal_glial_cell0.75670137
117MP0003091_abnormal_cell_migration0.75598092
118MP0000462_abnormal_digestive_system0.75365552
119MP0005503_abnormal_tendon_morphology0.74503015
120MP0003045_fibrosis0.73748771
121MP0000026_abnormal_inner_ear0.73458619
122MP0000579_abnormal_nail_morphology0.72242741
123MP0000647_abnormal_sebaceous_gland0.71191552
124MP0002081_perinatal_lethality0.70689921
125MP0002932_abnormal_joint_morphology0.70013865
126MP0002090_abnormal_vision0.69104836
127MP0003632_abnormal_nervous_system0.67704057
128MP0002896_abnormal_bone_mineralization0.67162357
129MP0008961_abnormal_basal_metabolism0.64816074
130MP0005620_abnormal_muscle_contractility0.63746814
131MP0004233_abnormal_muscle_weight0.63579237
132MP0002751_abnormal_autonomic_nervous0.63391072
133MP0003119_abnormal_digestive_system0.63356485
134MP0000534_abnormal_ureter_morphology0.63011927
135MP0005167_abnormal_blood-brain_barrier0.62865006
136MP0002249_abnormal_larynx_morphology0.59526489

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.67033160
2Focal seizures (HP:0007359)4.57885695
3Myokymia (HP:0002411)4.33875768
4Epileptic encephalopathy (HP:0200134)4.03024058
5Febrile seizures (HP:0002373)3.87970495
6Progressive cerebellar ataxia (HP:0002073)3.64142882
7Hyperventilation (HP:0002883)3.49676253
8Broad-based gait (HP:0002136)3.47351515
9Excessive salivation (HP:0003781)3.42904752
10Drooling (HP:0002307)3.42904752
11Visual hallucinations (HP:0002367)3.21106597
12Atonic seizures (HP:0010819)3.17830890
13Shallow orbits (HP:0000586)3.16617575
14Supranuclear gaze palsy (HP:0000605)3.00663089
15Action tremor (HP:0002345)3.00436825
16Atrophic scars (HP:0001075)2.95121756
17Generalized tonic-clonic seizures (HP:0002069)2.92224472
18Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.89746225
19Short 4th metacarpal (HP:0010044)2.89746225
20Absence seizures (HP:0002121)2.86216573
21Genetic anticipation (HP:0003743)2.75446251
22Absent speech (HP:0001344)2.74522011
23Dialeptic seizures (HP:0011146)2.64689208
24Hemiparesis (HP:0001269)2.63150294
25Arterial tortuosity (HP:0005116)2.62603652
26Dysdiadochokinesis (HP:0002075)2.59956556
27Gaze-evoked nystagmus (HP:0000640)2.58271376
28Vascular tortuosity (HP:0004948)2.57847509
29Urinary bladder sphincter dysfunction (HP:0002839)2.56320313
30Protrusio acetabuli (HP:0003179)2.55860465
31Abnormality of the corticospinal tract (HP:0002492)2.55851371
32Neoplasm of the heart (HP:0100544)2.55048396
33Amblyopia (HP:0000646)2.52716152
34Poor eye contact (HP:0000817)2.52374392
35Impaired vibration sensation in the lower limbs (HP:0002166)2.49574520
36Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.47589899
37Mutism (HP:0002300)2.44947573
38Lower limb amyotrophy (HP:0007210)2.40575268
39Truncal ataxia (HP:0002078)2.39908200
40Abnormality of salivation (HP:0100755)2.38757999
41Abnormal social behavior (HP:0012433)2.36264742
42Impaired social interactions (HP:0000735)2.36264742
43Premature rupture of membranes (HP:0001788)2.35448444
44Abnormality of the lower motor neuron (HP:0002366)2.34893854
45Termporal pattern (HP:0011008)2.33536774
46Insidious onset (HP:0003587)2.33536774
47Ankle clonus (HP:0011448)2.32918262
48Neonatal short-limb short stature (HP:0008921)2.30442148
49Epileptiform EEG discharges (HP:0011182)2.29448608
50Neurofibrillary tangles (HP:0002185)2.28982243
51Cerebral aneurysm (HP:0004944)2.26786124
52Alacrima (HP:0000522)2.25928456
53Dysmetria (HP:0001310)2.25711100
54Cerebral inclusion bodies (HP:0100314)2.23995635
55Exotropia (HP:0000577)2.22797869
56Long clavicles (HP:0000890)2.20576036
57Protruding tongue (HP:0010808)2.18819775
58EEG with generalized epileptiform discharges (HP:0011198)2.17708236
59Prolonged QT interval (HP:0001657)2.13785407
60Aqueductal stenosis (HP:0002410)2.13517146
61Stereotypic behavior (HP:0000733)2.12457038
62Hydroureter (HP:0000072)2.12237414
63Postural instability (HP:0002172)2.11356809
64Abnormality of the 4th metacarpal (HP:0010012)2.10149436
65Wrist flexion contracture (HP:0001239)2.08523057
66Laryngomalacia (HP:0001601)2.06160279
67Hypsarrhythmia (HP:0002521)2.05632103
68Overgrowth (HP:0001548)2.04419816
69Fetal akinesia sequence (HP:0001989)2.03849811
70Adactyly (HP:0009776)2.03778412
71Down-sloping shoulders (HP:0200021)2.01874780
72Obstructive sleep apnea (HP:0002870)2.01356395
73Depression (HP:0000716)2.01046955
74Short phalanx of the thumb (HP:0009660)2.00791606
75Agitation (HP:0000713)2.00432143
76Anxiety (HP:0000739)1.99533981
77Hammertoe (HP:0001765)1.99119871
78Morphological abnormality of the middle ear (HP:0008609)1.97916140
79Central scotoma (HP:0000603)1.97483078
80Aplasia/Hypoplasia of the sternum (HP:0006714)1.97050988
81Abnormal eating behavior (HP:0100738)1.95334258
82Limb dystonia (HP:0002451)1.94484888
83Wormian bones (HP:0002645)1.94235414
84Aplasia involving bones of the upper limbs (HP:0009823)1.94042938
85Aplasia of the phalanges of the hand (HP:0009802)1.94042938
86Aplasia involving bones of the extremities (HP:0009825)1.94042938
87Diplopia (HP:0000651)1.93546722
88Abnormality of binocular vision (HP:0011514)1.93546722
89Inappropriate behavior (HP:0000719)1.93384446
90Widely spaced teeth (HP:0000687)1.93344455
91Cutaneous syndactyly (HP:0012725)1.93332064
92Lower limb muscle weakness (HP:0007340)1.92014551
93Akinesia (HP:0002304)1.91679103
94Cerebral hemorrhage (HP:0001342)1.91302713
95Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.91265246
96Urinary urgency (HP:0000012)1.91202416
97Blue irides (HP:0000635)1.90564263
98Decreased lacrimation (HP:0000633)1.89754139
99Wide anterior fontanel (HP:0000260)1.89104255
100Lymphangioma (HP:0100764)1.88495838
101Bladder diverticulum (HP:0000015)1.88204955
102Megalencephaly (HP:0001355)1.87429300
103Spastic gait (HP:0002064)1.85905887
104Thickened helices (HP:0000391)1.84664442
105Progressive inability to walk (HP:0002505)1.82853929
106Tibial bowing (HP:0002982)1.82752031
107Torticollis (HP:0000473)1.82504684
108Hemiplegia (HP:0002301)1.81334559
109Visceral angiomatosis (HP:0100761)1.80968934
110Syncope (HP:0001279)1.80932567
111Pachygyria (HP:0001302)1.79907616
112Scanning speech (HP:0002168)1.79650146
113Skull defect (HP:0001362)1.79115103
114Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.78916676
115Degeneration of the lateral corticospinal tracts (HP:0002314)1.78916676
116Autism (HP:0000717)1.77841872
117Inability to walk (HP:0002540)1.77675181
118Open mouth (HP:0000194)1.77229735
119Polyphagia (HP:0002591)1.77035551
120Congenital stationary night blindness (HP:0007642)1.76908026
121Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.75660182
122Abnormal EKG (HP:0003115)1.75213650
123Spinal muscular atrophy (HP:0007269)1.75136175
124Germ cell neoplasia (HP:0100728)1.74656967
125Difficulty running (HP:0009046)1.74564945
126Limited hip movement (HP:0008800)1.74516266
127Gastroesophageal reflux (HP:0002020)1.74461383
128Cutaneous finger syndactyly (HP:0010554)1.74436941
129Hepatoblastoma (HP:0002884)1.73294332
130Impaired smooth pursuit (HP:0007772)1.71726716
131Difficulty climbing stairs (HP:0003551)1.71534755
132Impaired vibratory sensation (HP:0002495)1.71414121
133Intention tremor (HP:0002080)1.70137547
134Hyperthyroidism (HP:0000836)1.68587925
135Broad ribs (HP:0000885)1.67774731
136Hyperacusis (HP:0010780)1.66411721
137Abnormality of the distal phalanx of the thumb (HP:0009617)1.65316634
138Bowel diverticulosis (HP:0005222)1.65263811
139Hypoplasia of the brainstem (HP:0002365)1.64778734
140Aplasia/Hypoplasia of the brainstem (HP:0007362)1.64778734
141Hypoplastic labia majora (HP:0000059)1.64455297
142Hemangiomatosis (HP:0007461)1.63820095
143Deeply set eye (HP:0000490)1.63375299
144Distal lower limb amyotrophy (HP:0008944)1.63088837
145Generalized myoclonic seizures (HP:0002123)1.61049344
146Bronchomalacia (HP:0002780)1.60978000
147Increased density of long bones (HP:0006392)1.60670009
148Spinal rigidity (HP:0003306)1.60259668
149Mitral valve prolapse (HP:0001634)1.58087536
150Sudden death (HP:0001699)1.57852251
151Decreased central vision (HP:0007663)1.57696333
152Hypoventilation (HP:0002791)1.56903623
153Hypoplastic nipples (HP:0002557)1.56844167
154Fragile skin (HP:0001030)1.56730114
155Bicornuate uterus (HP:0000813)1.56386679
156Abnormality of the pubic bones (HP:0003172)1.55943923
157Mild short stature (HP:0003502)1.55520483
158Short 1st metacarpal (HP:0010034)1.54755151
159Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.54755151
160Abnormality of the labia majora (HP:0012881)1.54260299
161Hip contracture (HP:0003273)1.53839375
162Peripheral hypomyelination (HP:0007182)1.51426647
163Vertebral clefting (HP:0008428)1.51253015
164Abnormality of the labia minora (HP:0012880)1.50745276
165Soft skin (HP:0000977)1.50707624

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.71070798
2MARK14.67835879
3EPHA43.95734250
4NTRK33.87409568
5PINK13.03372138
6CASK2.84074312
7MAP3K42.71003029
8MAP3K92.45085662
9MAP2K72.23025970
10NTRK22.18582806
11PAK62.08694340
12SIK22.05134239
13DAPK21.98514458
14MINK11.97231190
15MAPK131.94087400
16TNIK1.89786080
17PNCK1.66042577
18MAP2K41.58970529
19CAMK1G1.53988474
20PTK21.51371360
21KSR11.50871670
22PHKG21.47228574
23PHKG11.47228574
24NTRK11.42351342
25PLK21.41834700
26PDGFRA1.40902619
27PRKD31.40256048
28MAP4K21.40171593
29CDK51.38612885
30EPHB21.33522400
31TGFBR21.29907982
32MET1.28973926
33INSRR1.25444854
34MARK21.15163903
35LATS21.14158104
36RIPK41.08880282
37PRPF4B1.07859781
38KSR21.07379137
39PKN11.06489195
40EPHA21.05454706
41CAMK2A1.05408113
42CAMKK11.04153953
43SGK4941.03344024
44SGK2231.03344024
45EEF2K1.03257174
46FGFR20.99931773
47SGK20.99054402
48STK110.95201673
49PAK30.94555520
50DMPK0.91453373
51PRKCG0.90593492
52FER0.87341595
53CSNK1G20.85755836
54STK380.84722336
55UHMK10.84162380
56SGK10.83303468
57DYRK20.80198782
58MAP3K20.79762853
59FES0.77519115
60PRKCE0.75923456
61CAMK2B0.75494561
62CAMK10.75343934
63MOS0.74985704
64DAPK10.74432407
65DYRK1A0.74309268
66BCR0.74184241
67GRK50.73999665
68TYRO30.73644357
69SGK30.72277557
70PRKCH0.71010663
71EPHA30.70656809
72RET0.70245818
73MAP3K60.69776659
74MST1R0.69506362
75CDC42BPA0.68015192
76PTK2B0.66241667
77LMTK20.65638555
78PRKCZ0.65154798
79PDGFRB0.64389563
80KDR0.62997857
81LATS10.62327522
82PKN20.62176276
83AKT30.60240297
84PIK3CA0.58724787
85CDK180.58246118
86CAMK1D0.57852670
87MAPK120.57663676
88ERBB20.57126050
89CDK150.56996531
90TAOK10.56746352
91CDK140.55477970
92CSNK1A1L0.54233336
93MAP3K120.53896845
94FGR0.53702107
95CAMK2D0.53183580
96TGFBR10.53093244
97ROCK10.50620061
98DDR20.50402056
99FYN0.49939621
100CAMK40.49838590
101RPS6KA20.49482977
102RPS6KA30.48798133
103OXSR10.48710592
104DYRK1B0.48496638
105BMPR20.47660834
106MAPK150.47606538
107ICK0.47285200
108NEK60.46896289
109PRKG10.46288282
110CAMKK20.45753436
111WNK10.45745089
112RIPK10.45332056
113CDK11A0.45284969
114MAPK100.45241161
115MAP2K10.44550522
116ERBB30.43917841
117ROCK20.42699120
118TTN0.42407080
119MTOR0.40405473
120TRPM70.40354293
121YES10.40183962
122MAPKAPK30.39460178
123PRKAA20.39223736
124GRK10.37817644
125PRKCB0.37655496
126MAP3K70.37396158
127ERBB40.37298660
128CAMK2G0.36668672
129WNK30.36342197
130TRIB30.35408755

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.36178989
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.42010241
3Circadian entrainment_Homo sapiens_hsa047132.41943359
4Glutamatergic synapse_Homo sapiens_hsa047242.37184013
5GABAergic synapse_Homo sapiens_hsa047272.30952410
6Morphine addiction_Homo sapiens_hsa050322.25190737
7Synaptic vesicle cycle_Homo sapiens_hsa047212.18746597
8Olfactory transduction_Homo sapiens_hsa047402.15103155
9Phototransduction_Homo sapiens_hsa047442.11864049
10Long-term potentiation_Homo sapiens_hsa047202.10315989
11Amphetamine addiction_Homo sapiens_hsa050312.03029434
12Salivary secretion_Homo sapiens_hsa049701.93469019
13Dopaminergic synapse_Homo sapiens_hsa047281.92411839
14Insulin secretion_Homo sapiens_hsa049111.83556690
15ECM-receptor interaction_Homo sapiens_hsa045121.83004336
16Taste transduction_Homo sapiens_hsa047421.78730330
17* Axon guidance_Homo sapiens_hsa043601.77386428
18Cholinergic synapse_Homo sapiens_hsa047251.76920134
19Renin secretion_Homo sapiens_hsa049241.75895201
20Serotonergic synapse_Homo sapiens_hsa047261.67215692
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64073154
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.63408560
23Gastric acid secretion_Homo sapiens_hsa049711.59722580
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59467442
25Oxytocin signaling pathway_Homo sapiens_hsa049211.54682942
26Cocaine addiction_Homo sapiens_hsa050301.52980363
27Long-term depression_Homo sapiens_hsa047301.51386573
28Calcium signaling pathway_Homo sapiens_hsa040201.50799007
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.44895932
30Type II diabetes mellitus_Homo sapiens_hsa049301.38296018
31GnRH signaling pathway_Homo sapiens_hsa049121.32733367
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32272043
33Gap junction_Homo sapiens_hsa045401.32234583
34cAMP signaling pathway_Homo sapiens_hsa040241.30691985
35Protein digestion and absorption_Homo sapiens_hsa049741.21441789
36Dilated cardiomyopathy_Homo sapiens_hsa054141.17890580
37Melanogenesis_Homo sapiens_hsa049161.16257019
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15285007
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13867603
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13005252
41ErbB signaling pathway_Homo sapiens_hsa040121.11658980
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10841264
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.07652418
44Glioma_Homo sapiens_hsa052141.05846807
45Estrogen signaling pathway_Homo sapiens_hsa049151.05038274
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04685329
47Dorso-ventral axis formation_Homo sapiens_hsa043201.02224736
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00298727
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.99099712
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98030403
51Notch signaling pathway_Homo sapiens_hsa043300.93005603
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90907343
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90653585
54Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.84886944
55Pancreatic secretion_Homo sapiens_hsa049720.84668090
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.83226356
57Choline metabolism in cancer_Homo sapiens_hsa052310.82984624
58Amoebiasis_Homo sapiens_hsa051460.81399434
59Cardiac muscle contraction_Homo sapiens_hsa042600.78271059
60Prion diseases_Homo sapiens_hsa050200.78129180
61Wnt signaling pathway_Homo sapiens_hsa043100.77636213
62Ras signaling pathway_Homo sapiens_hsa040140.77023549
63Collecting duct acid secretion_Homo sapiens_hsa049660.75090276
64Rap1 signaling pathway_Homo sapiens_hsa040150.74542757
65TGF-beta signaling pathway_Homo sapiens_hsa043500.73906868
66MAPK signaling pathway_Homo sapiens_hsa040100.73776818
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73275640
68Proteoglycans in cancer_Homo sapiens_hsa052050.72452308
69Endometrial cancer_Homo sapiens_hsa052130.69051068
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68674212
71MicroRNAs in cancer_Homo sapiens_hsa052060.63393581
72PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63124813
73Thyroid hormone synthesis_Homo sapiens_hsa049180.61522539
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61385113
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61209983
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61068746
77Ovarian steroidogenesis_Homo sapiens_hsa049130.60909903
78Renal cell carcinoma_Homo sapiens_hsa052110.60268966
79Glucagon signaling pathway_Homo sapiens_hsa049220.59385432
80Bile secretion_Homo sapiens_hsa049760.59239433
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58451310
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57404690
83VEGF signaling pathway_Homo sapiens_hsa043700.56261046
84Pathways in cancer_Homo sapiens_hsa052000.55921828
85Circadian rhythm_Homo sapiens_hsa047100.54776100
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.54604010
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53064376
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52812745
89Endocytosis_Homo sapiens_hsa041440.52341705
90Basal cell carcinoma_Homo sapiens_hsa052170.51719463
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51519196
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.51293772
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51041925
94Insulin signaling pathway_Homo sapiens_hsa049100.50453204
95Hedgehog signaling pathway_Homo sapiens_hsa043400.50099889
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49136910
97Colorectal cancer_Homo sapiens_hsa052100.47140821
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46685987
99Oocyte meiosis_Homo sapiens_hsa041140.46301361
100Melanoma_Homo sapiens_hsa052180.45512114
101mTOR signaling pathway_Homo sapiens_hsa041500.43517335
102Tight junction_Homo sapiens_hsa045300.43121858
103Nitrogen metabolism_Homo sapiens_hsa009100.42409325
104Hippo signaling pathway_Homo sapiens_hsa043900.42360118
105Inositol phosphate metabolism_Homo sapiens_hsa005620.39944097
106Focal adhesion_Homo sapiens_hsa045100.39154335
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39152439
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38647235
109Vibrio cholerae infection_Homo sapiens_hsa051100.37509638
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37177359
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37036459
112African trypanosomiasis_Homo sapiens_hsa051430.36438299
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36105102
114Adherens junction_Homo sapiens_hsa045200.35802714
115AMPK signaling pathway_Homo sapiens_hsa041520.34886553
116Non-small cell lung cancer_Homo sapiens_hsa052230.33419924

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