PLXNA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as apoptosis. Studies of a similar gene in zebrafish suggest that it is important for axon pathfinding in the developing nervous system. This gene may be associated with tumor progression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.41546845
2layer formation in cerebral cortex (GO:0021819)5.40067894
3cell migration in hindbrain (GO:0021535)5.04396411
4axonal fasciculation (GO:0007413)5.01805965
5nucleobase catabolic process (GO:0046113)4.97456532
6neuron cell-cell adhesion (GO:0007158)4.94024822
7response to pheromone (GO:0019236)4.88154463
8central nervous system projection neuron axonogenesis (GO:0021952)4.75643940
9neuron recognition (GO:0008038)4.65735816
10dendritic spine morphogenesis (GO:0060997)4.54847550
11dendrite morphogenesis (GO:0048813)4.44223982
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.34460700
13vocalization behavior (GO:0071625)4.32060533
14regulation of short-term neuronal synaptic plasticity (GO:0048172)4.30660574
15locomotory exploration behavior (GO:0035641)4.23630232
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.22717568
17negative regulation of microtubule polymerization (GO:0031115)4.18473198
18postsynaptic membrane organization (GO:0001941)4.09280389
19protein localization to synapse (GO:0035418)4.07920064
20establishment of nucleus localization (GO:0040023)3.81222804
21protein heterotrimerization (GO:0070208)3.79304253
22* semaphorin-plexin signaling pathway (GO:0071526)3.77794072
23axon extension (GO:0048675)3.71768450
24synaptic vesicle maturation (GO:0016188)3.70534904
25central nervous system neuron axonogenesis (GO:0021955)3.66385490
26regulation of glutamate receptor signaling pathway (GO:1900449)3.65533193
27positive regulation of synapse maturation (GO:0090129)3.65070630
28exploration behavior (GO:0035640)3.64107354
29positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.62293482
30regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.61767778
31regulation of synapse structural plasticity (GO:0051823)3.51871872
32cerebellar Purkinje cell differentiation (GO:0021702)3.41318406
33auditory behavior (GO:0031223)3.36402981
34synaptic vesicle exocytosis (GO:0016079)3.33617034
35positive regulation of synapse assembly (GO:0051965)3.27697999
36neuron projection extension (GO:1990138)3.23034053
37regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.20230234
38regulation of synaptic vesicle exocytosis (GO:2000300)3.19637993
39cerebellum development (GO:0021549)3.17609451
40proline transport (GO:0015824)3.16982370
41cerebral cortex radially oriented cell migration (GO:0021799)3.11275535
42cerebellar Purkinje cell layer development (GO:0021680)3.11175319
43glutamate secretion (GO:0014047)3.06905150
44insulin-like growth factor receptor signaling pathway (GO:0048009)3.06584760
45negative regulation of catenin import into nucleus (GO:0035414)3.05850973
46ionotropic glutamate receptor signaling pathway (GO:0035235)3.04071718
47spinal cord development (GO:0021510)3.03940008
48neuron migration (GO:0001764)3.02823209
49regulation of respiratory system process (GO:0044065)3.02560615
50positive regulation of histone deacetylation (GO:0031065)3.02108636
51endothelial cell chemotaxis (GO:0035767)3.02028903
52bone trabecula formation (GO:0060346)3.00469044
53collagen fibril organization (GO:0030199)2.96460359
54positive regulation of dendritic spine morphogenesis (GO:0061003)2.96414518
55dermatan sulfate metabolic process (GO:0030205)2.96192016
56positive regulation of axon extension (GO:0045773)2.95630604
57regulation of neuronal synaptic plasticity (GO:0048168)2.95240163
58cranial nerve morphogenesis (GO:0021602)2.94208499
59cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.92504143
60neurotransmitter secretion (GO:0007269)2.91925807
61synaptic vesicle docking involved in exocytosis (GO:0016081)2.91637849
62regulation of long-term neuronal synaptic plasticity (GO:0048169)2.91349099
63cerebellar granule cell differentiation (GO:0021707)2.90029620
64positive regulation of protein kinase C signaling (GO:0090037)2.88564941
65cell differentiation in hindbrain (GO:0021533)2.86926658
66clathrin coat assembly (GO:0048268)2.85972030
67negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.85937011
68endocardial cushion development (GO:0003197)2.85885967
69hemidesmosome assembly (GO:0031581)2.84901286
70regulation of synapse assembly (GO:0051963)2.84484478
71innervation (GO:0060384)2.83952483
72* hippocampus development (GO:0021766)2.83882854
73regulation of synapse maturation (GO:0090128)2.83700097
74synapse assembly (GO:0007416)2.83143228
75* regulation of axon extension (GO:0030516)2.83122860
76negative regulation of fatty acid transport (GO:2000192)2.82171499
77regulation of neuron migration (GO:2001222)2.82126908
78response to auditory stimulus (GO:0010996)2.82010566
79positive regulation of CREB transcription factor activity (GO:0032793)2.81998957
80ear development (GO:0043583)2.81108258
81positive regulation of fatty acid beta-oxidation (GO:0032000)2.81100448
82regulation of synapse organization (GO:0050807)2.80838560
83homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.79794295
84neuron projection morphogenesis (GO:0048812)2.78831590
85mannose metabolic process (GO:0006013)2.78410683
86regulation of fatty acid beta-oxidation (GO:0031998)2.77949095
87positive regulation of synaptic transmission, GABAergic (GO:0032230)2.77149947
88* regulation of axon extension involved in axon guidance (GO:0048841)2.76985065
89dendritic spine organization (GO:0097061)2.76016225
90planar cell polarity pathway involved in neural tube closure (GO:0090179)2.75264963
91axonogenesis (GO:0007409)2.73554527
92dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.72845342
93synapse organization (GO:0050808)2.71962423
94regulation of synaptic vesicle transport (GO:1902803)2.71788834
95regulation of dendritic spine morphogenesis (GO:0061001)2.70830351
96regulation of respiratory gaseous exchange (GO:0043576)2.70189438
97glutamate receptor signaling pathway (GO:0007215)2.69600163
98positive regulation of dendritic spine development (GO:0060999)2.69237567
99synaptic transmission, glutamatergic (GO:0035249)2.69152197
100* regulation of axon guidance (GO:1902667)2.67779819
101cerebral cortex neuron differentiation (GO:0021895)2.64833503
102negative regulation of cell size (GO:0045792)2.63996687
103* negative regulation of axon extension (GO:0030517)2.63755573
104neurotransmitter-gated ion channel clustering (GO:0072578)2.62786074
105neuronal ion channel clustering (GO:0045161)2.61722632
106forebrain neuron differentiation (GO:0021879)2.61424133
107cell-cell junction maintenance (GO:0045217)2.61281389
108synaptic vesicle endocytosis (GO:0048488)2.60430524
109* regulation of extent of cell growth (GO:0061387)2.60198586
110regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.59783614
111glial cell proliferation (GO:0014009)2.59080805
112vascular endothelial growth factor signaling pathway (GO:0038084)2.59003810
113dopamine receptor signaling pathway (GO:0007212)2.58555265
114transmission of nerve impulse (GO:0019226)2.58294926
115presynaptic membrane assembly (GO:0097105)2.58068651
116neuromuscular process controlling balance (GO:0050885)2.57704199
117positive regulation of filopodium assembly (GO:0051491)2.56985641
118positive regulation of dendrite morphogenesis (GO:0050775)2.56533787
119establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.55169588
120mitochondrion transport along microtubule (GO:0047497)2.55169588
121positive regulation of gastrulation (GO:2000543)2.54722119
122establishment of tissue polarity (GO:0007164)2.54644522
123establishment of planar polarity (GO:0001736)2.54644522
124calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.54638819
125establishment or maintenance of monopolar cell polarity (GO:0061339)2.52771245
126establishment of monopolar cell polarity (GO:0061162)2.52771245
127camera-type eye morphogenesis (GO:0048593)2.52336373
128kidney mesenchyme development (GO:0072074)2.50923775
129neuron remodeling (GO:0016322)2.48971163
130positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.48405904
131Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.47387752
132endodermal cell differentiation (GO:0035987)2.46078219
133regulation of hippo signaling (GO:0035330)2.45787147
134skin morphogenesis (GO:0043589)2.44855589
135dermatan sulfate biosynthetic process (GO:0030208)2.44777991
136collecting duct development (GO:0072044)2.44076904
137neuron projection extension involved in neuron projection guidance (GO:1902284)2.43860346
138axon extension involved in axon guidance (GO:0048846)2.43860346
139regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.41404317
140positive regulation of blood vessel endothelial cell migration (GO:0043536)2.41219284
141neural tube development (GO:0021915)2.40848931
142venous blood vessel morphogenesis (GO:0048845)2.39510414
143negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.39486157
144atrioventricular valve morphogenesis (GO:0003181)2.39432963
145metanephric mesenchyme development (GO:0072075)2.37646497
146urinary tract smooth muscle contraction (GO:0014848)2.35267436
147regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.34115067
148ganglion development (GO:0061548)2.32192087
149regulation of establishment of planar polarity (GO:0090175)2.31229838
150establishment of apical/basal cell polarity (GO:0035089)2.30342132
151basement membrane organization (GO:0071711)2.28565586
152uterus development (GO:0060065)2.27357505
153convergent extension (GO:0060026)2.26410667
154cell-substrate junction assembly (GO:0007044)2.25458969
155macroautophagy (GO:0016236)2.23566780
156desmosome organization (GO:0002934)2.23364486
157vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.22628609
158lung epithelium development (GO:0060428)2.22227282
159neuron maturation (GO:0042551)2.21421549
160embryonic retina morphogenesis in camera-type eye (GO:0060059)2.20753365
161head development (GO:0060322)2.19974908
162nephron epithelium morphogenesis (GO:0072088)2.19354790
163nephron tubule morphogenesis (GO:0072078)2.19354790
164regulation of histone deacetylation (GO:0031063)2.19318391
165cell junction maintenance (GO:0034331)2.17449013
166adherens junction assembly (GO:0034333)2.16188191
167myoblast fusion (GO:0007520)2.14870356
168syncytium formation by plasma membrane fusion (GO:0000768)2.13894721
169female genitalia development (GO:0030540)2.10486942
170chondrocyte proliferation (GO:0035988)2.10352261
171* negative regulation of axon extension involved in axon guidance (GO:0048843)2.10086970
172substrate-dependent cell migration (GO:0006929)2.09651192
173cell migration involved in sprouting angiogenesis (GO:0002042)2.09530521
174positive regulation of fatty acid oxidation (GO:0046321)2.09357314
175glomerular basement membrane development (GO:0032836)2.09237009
176regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.07653356
177cochlea morphogenesis (GO:0090103)2.07133039
178regulation of endothelial cell chemotaxis (GO:2001026)2.06517616
179actin filament depolymerization (GO:0030042)2.06413069
180tooth mineralization (GO:0034505)2.06150525
181endothelial cell morphogenesis (GO:0001886)2.04896222

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.19341828
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.45677220
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.17355407
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.99822475
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.93664876
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.87534758
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.83308905
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.75778315
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.75231300
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.75231300
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.66908973
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.64731091
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.62253817
14GBX2_23144817_ChIP-Seq_PC3_Human2.57095834
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52925730
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.46075548
17EZH2_27294783_Chip-Seq_ESCs_Mouse2.45779387
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.40459741
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.38979980
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.37860817
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37078588
22ESR2_21235772_ChIP-Seq_MCF-7_Human2.36525606
23RARG_19884340_ChIP-ChIP_MEFs_Mouse2.33839572
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.32111951
25REST_21632747_ChIP-Seq_MESCs_Mouse2.25630851
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.24580727
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.19833538
28MTF2_20144788_ChIP-Seq_MESCs_Mouse2.17431288
29DROSHA_22980978_ChIP-Seq_HELA_Human2.10261699
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.08450905
31ESR1_21235772_ChIP-Seq_MCF-7_Human2.08067723
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.96588997
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.96091066
34LXR_22292898_ChIP-Seq_THP-1_Human1.95402439
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.94976708
36ZFP281_18757296_ChIP-ChIP_E14_Mouse1.92928705
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.87100670
38ZNF274_21170338_ChIP-Seq_K562_Hela1.86815705
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.82378316
40RING1B_27294783_Chip-Seq_ESCs_Mouse1.81303103
41RING1B_27294783_Chip-Seq_NPCs_Mouse1.79607223
42RARB_27405468_Chip-Seq_BRAIN_Mouse1.78029963
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.75897833
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.74458728
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.73977317
46AR_21572438_ChIP-Seq_LNCaP_Human1.63899629
47EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.63641931
48RACK7_27058665_Chip-Seq_MCF-7_Human1.63125388
49RNF2_27304074_Chip-Seq_NSC_Mouse1.62910661
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.60212576
51TP53_22127205_ChIP-Seq_IMR90_Human1.57784901
52TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.56441013
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56127823
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.54658084
55KDM2B_26808549_Chip-Seq_K562_Human1.52467176
56ZFP281_27345836_Chip-Seq_ESCs_Mouse1.52160884
57OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.51543595
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49909603
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.49033560
60KDM2B_26808549_Chip-Seq_DND41_Human1.46060792
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.45878212
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.44987989
63MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.44007554
64TP53_20018659_ChIP-ChIP_R1E_Mouse1.40455108
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40100695
66TP53_23651856_ChIP-Seq_MEFs_Mouse1.37799030
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37306337
68RUNX1_27514584_Chip-Seq_MCF-7_Human1.36595965
69UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30222709
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29003112
71NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.28360927
72RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.28067425
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.26573946
74CREB1_26743006_Chip-Seq_LNCaP_Human1.25889055
75PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.24224244
76WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22739009
77DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22418287
78HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21367420
79SMC4_20622854_ChIP-Seq_HELA_Human1.19590267
80AR_19668381_ChIP-Seq_PC3_Human1.19088519
81DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.18753824
82ISL1_27105846_Chip-Seq_CPCs_Mouse1.17650851
83* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16934524
84P68_20966046_ChIP-Seq_HELA_Human1.16748480
85YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16248999
86TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15434170
87NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14003464
88SOX2_21211035_ChIP-Seq_LN229_Gbm1.13569506
89AHR_22903824_ChIP-Seq_MCF-7_Human1.13357856
90ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12212419
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.11660864
92SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10446948
93SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09488844
94TAF15_26573619_Chip-Seq_HEK293_Human1.09177516
95RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08981518
96IGF1R_20145208_ChIP-Seq_DFB_Human1.08704694
97ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08329243
98TCF7_22412390_ChIP-Seq_EML_Mouse1.07765233
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.06143702
100ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06099036
101TP63_22573176_ChIP-Seq_HFKS_Human1.05919877
102* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05759037
103RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05549287
104TET1_21451524_ChIP-Seq_MESCs_Mouse1.04936123
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04712319
106* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04657809
107ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04241022
108KDM2B_26808549_Chip-Seq_JURKAT_Human1.04199534
109KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04195725
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03144824
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03144824
112CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02802720
113P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02649635
114SALL1_21062744_ChIP-ChIP_HESCs_Human1.01927467
115TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.01524682
116ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01378486
117MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.01235285
118SMAD3_21741376_ChIP-Seq_ESCs_Human1.00404884
119* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00233666
120SMAD4_21799915_ChIP-Seq_A2780_Human1.00082277
121SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99946832
122P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98528112
123TP63_19390658_ChIP-ChIP_HaCaT_Human0.98432384
124GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97413990
125POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94874604
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94256361
127CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93983173
128TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93940065
129SMC3_22415368_ChIP-Seq_MEFs_Mouse0.93879323
130CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93012819
131SA1_27219007_Chip-Seq_ERYTHROID_Human0.92973265
132ELK4_26923725_Chip-Seq_MESODERM_Mouse0.90508847
133CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90405182
134CTCF_27219007_Chip-Seq_Bcells_Human0.90392046
135OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90366563
136ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90084447
137SMAD4_21741376_ChIP-Seq_HESCs_Human0.89792449
138AR_25329375_ChIP-Seq_VCAP_Human0.88081780
139NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88074037
140P300_19829295_ChIP-Seq_ESCs_Human0.87775569
141NR3C1_23031785_ChIP-Seq_PC12_Mouse0.86972584
142CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.85245131
143VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84712763
144TET1_21490601_ChIP-Seq_MESCs_Mouse0.83539373

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.52443038
2MP0004859_abnormal_synaptic_plasticity4.15864023
3MP0003705_abnormal_hypodermis_morpholog3.87560225
4MP0005503_abnormal_tendon_morphology3.69102410
5MP0003122_maternal_imprinting3.24869131
6MP0003279_aneurysm3.18794989
7MP0000778_abnormal_nervous_system3.18316114
8MP0005423_abnormal_somatic_nervous3.14314232
9MP0009384_cardiac_valve_regurgitation2.99341447
10MP0003880_abnormal_central_pattern2.87995125
11MP0001958_emphysema2.83437592
12MP0005257_abnormal_intraocular_pressure2.80234128
13MP0003635_abnormal_synaptic_transmissio2.75188107
14MP0004270_analgesia2.53347881
15MP0002063_abnormal_learning/memory/cond2.35757814
16MP0006276_abnormal_autonomic_nervous2.33801398
17MP0005645_abnormal_hypothalamus_physiol2.32794537
18* MP0002184_abnormal_innervation2.29077268
19MP0000537_abnormal_urethra_morphology2.17335886
20MP0000569_abnormal_digit_pigmentation2.16047336
21MP0004272_abnormal_basement_membrane2.09654673
22MP0005409_darkened_coat_color2.07027323
23MP0004858_abnormal_nervous_system2.01621874
24MP0001984_abnormal_olfaction1.98167156
25MP0005275_abnormal_skin_tensile1.93536257
26MP0002734_abnormal_mechanical_nocicepti1.93522184
27MP0003121_genomic_imprinting1.91755645
28MP0000538_abnormal_urinary_bladder1.81395950
29MP0010030_abnormal_orbit_morphology1.80742085
30MP0009745_abnormal_behavioral_response1.79805652
31MP0000955_abnormal_spinal_cord1.78178900
32MP0002572_abnormal_emotion/affect_behav1.77996531
33MP0005499_abnormal_olfactory_system1.77474885
34MP0005394_taste/olfaction_phenotype1.77474885
35MP0002557_abnormal_social/conspecific_i1.76295434
36MP0002234_abnormal_pharynx_morphology1.71314708
37MP0005508_abnormal_skeleton_morphology1.68714989
38MP0001849_ear_inflammation1.68358870
39MP0004811_abnormal_neuron_physiology1.68273103
40MP0008789_abnormal_olfactory_epithelium1.66020537
41MP0002064_seizures1.65447275
42MP0001486_abnormal_startle_reflex1.63013418
43MP0001968_abnormal_touch/_nociception1.62595442
44MP0000631_abnormal_neuroendocrine_gland1.60219994
45MP0003283_abnormal_digestive_organ1.58481178
46MP0000767_abnormal_smooth_muscle1.56157200
47* MP0003861_abnormal_nervous_system1.54047626
48MP0009780_abnormal_chondrocyte_physiolo1.53859419
49* MP0002882_abnormal_neuron_morphology1.51599422
50MP0002733_abnormal_thermal_nociception1.49360453
51MP0003787_abnormal_imprinting1.48638964
52* MP0002152_abnormal_brain_morphology1.45093883
53MP0002108_abnormal_muscle_morphology1.43803841
54MP0002735_abnormal_chemical_nociception1.42485377
55MP0002067_abnormal_sensory_capabilities1.41463164
56MP0010368_abnormal_lymphatic_system1.40634390
57MP0000003_abnormal_adipose_tissue1.40568509
58MP0003385_abnormal_body_wall1.39977570
59MP0001299_abnormal_eye_distance/1.39013765
60MP0009046_muscle_twitch1.35746929
61MP0001440_abnormal_grooming_behavior1.34365086
62MP0006292_abnormal_olfactory_placode1.32793861
63MP0003566_abnormal_cell_adhesion1.32680512
64MP0000013_abnormal_adipose_tissue1.32498791
65MP0003942_abnormal_urinary_system1.31995556
66MP0002751_abnormal_autonomic_nervous1.31909100
67MP0003890_abnormal_embryonic-extraembry1.31722129
68MP0003119_abnormal_digestive_system1.30735039
69MP0002896_abnormal_bone_mineralization1.25895307
70MP0000534_abnormal_ureter_morphology1.25307583
71MP0002272_abnormal_nervous_system1.24137420
72MP0001529_abnormal_vocalization1.23910840
73MP0000049_abnormal_middle_ear1.23514463
74MP0003091_abnormal_cell_migration1.23509388
75MP0001970_abnormal_pain_threshold1.22636461
76MP0008961_abnormal_basal_metabolism1.22326922
77MP0002638_abnormal_pupillary_reflex1.22109991
78MP0002653_abnormal_ependyma_morphology1.21556799
79MP0004885_abnormal_endolymph1.20672921
80MP0002060_abnormal_skin_morphology1.20181979
81MP0004924_abnormal_behavior1.20126228
82MP0005386_behavior/neurological_phenoty1.20126228
83MP0002102_abnormal_ear_morphology1.17539147
84MP0000579_abnormal_nail_morphology1.16100966
85MP0005187_abnormal_penis_morphology1.16074010
86MP0005595_abnormal_vascular_smooth1.14377217
87MP0001502_abnormal_circadian_rhythm1.13449727
88MP0001542_abnormal_bone_strength1.11284168
89MP0008569_lethality_at_weaning1.10664713
90MP0000733_abnormal_muscle_development1.08723774
91MP0004742_abnormal_vestibular_system1.07749327
92MP0002736_abnormal_nociception_after1.07689559
93MP0003938_abnormal_ear_development1.06963235
94MP0002909_abnormal_adrenal_gland1.06941899
95* MP0002752_abnormal_somatic_nervous1.05031139
96MP0004134_abnormal_chest_morphology1.04591337
97MP0000566_synostosis1.04416622
98MP0002066_abnormal_motor_capabilities/c1.04382788
99MP0009053_abnormal_anal_canal1.03138558
100MP0002116_abnormal_craniofacial_bone1.02402610
101MP0003172_abnormal_lysosome_physiology1.01306397
102MP0002081_perinatal_lethality1.01184240
103MP0000467_abnormal_esophagus_morphology1.00184405
104MP0009840_abnormal_foam_cell0.98105745
105MP0005623_abnormal_meninges_morphology0.97359283
106MP0003755_abnormal_palate_morphology0.97210560
107MP0002233_abnormal_nose_morphology0.97200228
108MP0003045_fibrosis0.94200900
109MP0004133_heterotaxia0.93542971
110MP0002249_abnormal_larynx_morphology0.92869304
111MP0002938_white_spotting0.92782317
112MP0000427_abnormal_hair_cycle0.92737783
113MP0001348_abnormal_lacrimal_gland0.92689259
114MP0002933_joint_inflammation0.92551676
115MP0000026_abnormal_inner_ear0.90969455
116MP0005646_abnormal_pituitary_gland0.90231559
117MP0005076_abnormal_cell_differentiation0.89771819
118MP0000678_abnormal_parathyroid_gland0.88771063
119MP0003137_abnormal_impulse_conducting0.88694216
120MP0000751_myopathy0.86842494
121MP0000470_abnormal_stomach_morphology0.84673398
122MP0000432_abnormal_head_morphology0.84569256
123MP0003115_abnormal_respiratory_system0.84157251
124MP0003123_paternal_imprinting0.83934846
125MP0009250_abnormal_appendicular_skeleto0.83910095
126MP0000163_abnormal_cartilage_morphology0.83285924
127MP0002089_abnormal_postnatal_growth/wei0.82441401
128MP0002932_abnormal_joint_morphology0.82400620
129MP0000428_abnormal_craniofacial_morphol0.82265798
130MP0000383_abnormal_hair_follicle0.81139367
131MP0001879_abnormal_lymphatic_vessel0.80654129
132MP0010386_abnormal_urinary_bladder0.80482698
133MP0002254_reproductive_system_inflammat0.80275622
134MP0003935_abnormal_craniofacial_develop0.78794741
135MP0001270_distended_abdomen0.78546990
136MP0002115_abnormal_skeleton_extremities0.78533238
137MP0002282_abnormal_trachea_morphology0.78154603
138MP0003329_amyloid_beta_deposits0.77833979
139MP0000462_abnormal_digestive_system0.76976697
140MP0002069_abnormal_eating/drinking_beha0.76382725
141MP0001943_abnormal_respiration0.76212814
142MP0001243_abnormal_dermal_layer0.76106046
143MP0002177_abnormal_outer_ear0.75444092
144MP0002925_abnormal_cardiovascular_devel0.75432643
145MP0002114_abnormal_axial_skeleton0.74876736
146MP0005390_skeleton_phenotype0.74841447
147MP0004233_abnormal_muscle_weight0.74495766
148MP0005023_abnormal_wound_healing0.73166865
149MP0000762_abnormal_tongue_morphology0.71182509
150MP0003879_abnormal_hair_cell0.70407256
151MP0003948_abnormal_gas_homeostasis0.67987748

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.57668820
2Protrusio acetabuli (HP:0003179)4.18469159
3Atrophic scars (HP:0001075)3.38268519
4Cervical subluxation (HP:0003308)3.26917731
5Cerebral aneurysm (HP:0004944)3.23226006
6Broad metatarsal (HP:0001783)3.21796619
7Hyperacusis (HP:0010780)3.12374848
8Broad face (HP:0000283)3.01911027
9Focal seizures (HP:0007359)2.99505613
10Genu recurvatum (HP:0002816)2.95872039
11Myokymia (HP:0002411)2.94193810
12Short 4th metacarpal (HP:0010044)2.87459203
13Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.87459203
14J-shaped sella turcica (HP:0002680)2.86405182
15Abnormality of the labia minora (HP:0012880)2.85314679
16Aortic dissection (HP:0002647)2.84189919
17Fragile skin (HP:0001030)2.78294539
18Thin bony cortex (HP:0002753)2.76223553
19Polyphagia (HP:0002591)2.74718732
20Insomnia (HP:0100785)2.74581609
21Ankle clonus (HP:0011448)2.73157878
22Focal motor seizures (HP:0011153)2.69665130
23Failure to thrive in infancy (HP:0001531)2.67631304
24Renal duplication (HP:0000075)2.67556191
25Supranuclear gaze palsy (HP:0000605)2.66691191
26Aqueductal stenosis (HP:0002410)2.65716825
27Abnormality of dentin (HP:0010299)2.65426495
28Elfin facies (HP:0004428)2.62472620
29Neonatal short-limb short stature (HP:0008921)2.62147389
30Aortic regurgitation (HP:0001659)2.58633575
31Ankle contracture (HP:0006466)2.58075638
32Visual hallucinations (HP:0002367)2.57421745
33Limb dystonia (HP:0002451)2.57014834
34Amyotrophic lateral sclerosis (HP:0007354)2.56370627
35Vascular tortuosity (HP:0004948)2.52400538
36Excessive salivation (HP:0003781)2.52279739
37Drooling (HP:0002307)2.52279739
38Soft skin (HP:0000977)2.49915793
39Bronchomalacia (HP:0002780)2.49810086
40Overriding aorta (HP:0002623)2.46036000
41Shoulder girdle muscle weakness (HP:0003547)2.42692981
42Renovascular hypertension (HP:0100817)2.40777125
43Biconcave vertebral bodies (HP:0004586)2.39789069
44Shallow orbits (HP:0000586)2.39449304
45Aplasia/Hypoplasia of the brainstem (HP:0007362)2.38108929
46Hypoplasia of the brainstem (HP:0002365)2.38108929
47Arterial tortuosity (HP:0005116)2.37602500
48Sleep apnea (HP:0010535)2.37177778
49Hepatoblastoma (HP:0002884)2.36828645
50Mitral regurgitation (HP:0001653)2.35835991
51Progressive cerebellar ataxia (HP:0002073)2.34318895
52Ulnar bowing (HP:0003031)2.32341118
53Macroorchidism (HP:0000053)2.32181713
54Abnormality of the lower motor neuron (HP:0002366)2.31258213
55Mutism (HP:0002300)2.30339789
56Long toe (HP:0010511)2.29407602
57Follicular hyperkeratosis (HP:0007502)2.26523841
58Hypoventilation (HP:0002791)2.25297474
59Lissencephaly (HP:0001339)2.23647767
60Upper limb amyotrophy (HP:0009129)2.23226344
61Distal upper limb amyotrophy (HP:0007149)2.23226344
62Pointed chin (HP:0000307)2.23089511
63Abnormality of the corticospinal tract (HP:0002492)2.22556051
64Mitral valve prolapse (HP:0001634)2.20941576
65Mildly elevated creatine phosphokinase (HP:0008180)2.20364258
66Overgrowth (HP:0001548)2.18939078
67Epileptic encephalopathy (HP:0200134)2.18861724
68Wide anterior fontanel (HP:0000260)2.17369319
69Blue sclerae (HP:0000592)2.16999376
70Infantile muscular hypotonia (HP:0008947)2.16145790
71Lymphangioma (HP:0100764)2.15142044
72Abnormality of the 4th metacarpal (HP:0010012)2.14694271
73Wormian bones (HP:0002645)2.13944269
74Astrocytoma (HP:0009592)2.13125565
75Abnormality of the astrocytes (HP:0100707)2.13125565
76Sacral dimple (HP:0000960)2.12379550
77Amblyopia (HP:0000646)2.11957257
78Spinal rigidity (HP:0003306)2.10260747
79Hypoplastic ischia (HP:0003175)2.09958900
80Joint stiffness (HP:0001387)2.08300534
81Wrist flexion contracture (HP:0001239)2.07736147
82Megalencephaly (HP:0001355)2.07643990
83Flat cornea (HP:0007720)2.07551337
84Disproportionate tall stature (HP:0001519)2.07535056
85Shawl scrotum (HP:0000049)2.07363751
86Agitation (HP:0000713)2.06989375
87Heterotopia (HP:0002282)2.06950912
88Tibial bowing (HP:0002982)2.06163396
89Joint laxity (HP:0001388)2.05844726
90Aortic aneurysm (HP:0004942)2.03547640
91Open mouth (HP:0000194)2.02064648
92Broad-based gait (HP:0002136)2.02009652
93Genetic anticipation (HP:0003743)2.01861833
94Narrow nasal bridge (HP:0000446)2.01474443
95Stridor (HP:0010307)1.98645084
96Neoplasm of the heart (HP:0100544)1.97946249
97Aortic valve stenosis (HP:0001650)1.97569552
98Morphological abnormality of the middle ear (HP:0008609)1.96611098
99Exotropia (HP:0000577)1.95793861
100Abnormal eating behavior (HP:0100738)1.94667861
101Long eyelashes (HP:0000527)1.93050399
102Bowel diverticulosis (HP:0005222)1.92895961
103Pelvic girdle muscle weakness (HP:0003749)1.92392623
104Termporal pattern (HP:0011008)1.92369628
105Insidious onset (HP:0003587)1.92369628
106Cutaneous finger syndactyly (HP:0010554)1.91024191
107Spondylolisthesis (HP:0003302)1.90774009
108Hemiparesis (HP:0001269)1.90566077
109Abnormality of the diencephalon (HP:0010662)1.90211647
110Absence seizures (HP:0002121)1.88778312
111Deformed sella turcica (HP:0002681)1.88240138
112Buphthalmos (HP:0000557)1.88224011
113Megalocornea (HP:0000485)1.87730745
114Akinesia (HP:0002304)1.87699540
115Urinary urgency (HP:0000012)1.87331623
116Pachygyria (HP:0001302)1.87159483
117Action tremor (HP:0002345)1.86721305
118Obstructive sleep apnea (HP:0002870)1.86660084
119Aneurysm (HP:0002617)1.86566907
120Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.85774578
121Atonic seizures (HP:0010819)1.84869441
122Patellar dislocation (HP:0002999)1.83634884
123Abnormality of the musculature of the pelvis (HP:0001469)1.81772490
124Abnormality of the hip-girdle musculature (HP:0001445)1.81772490
125Congenital glaucoma (HP:0001087)1.81417069
126Febrile seizures (HP:0002373)1.81328384
127Peritonitis (HP:0002586)1.81084229
128EEG with generalized epileptiform discharges (HP:0011198)1.80786324
129Abnormality of the ischium (HP:0003174)1.79592097
130Labial hypoplasia (HP:0000066)1.79296815
131Apathy (HP:0000741)1.78782503
132Abnormality of the odontoid process (HP:0003310)1.78066740
133Bladder diverticulum (HP:0000015)1.77387366
134Abnormality of the aortic arch (HP:0012303)1.77288250
135Hyperextensible skin (HP:0000974)1.76742946
136Specific learning disability (HP:0001328)1.76037268
137Hypsarrhythmia (HP:0002521)1.75755433
138Cutaneous syndactyly (HP:0012725)1.75436318
139Abnormality of the sella turcica (HP:0002679)1.75268012
140Trigonocephaly (HP:0000243)1.75248473
141Bowed forearm bones (HP:0003956)1.74842219
142Bowing of the arm (HP:0006488)1.74842219
143Hyperthyroidism (HP:0000836)1.74771681
144Osteoarthritis (HP:0002758)1.73489473
145Sporadic (HP:0003745)1.72694559
146Cortical dysplasia (HP:0002539)1.72685054
147Epileptiform EEG discharges (HP:0011182)1.72678273
148Depression (HP:0000716)1.72490512
149Obsessive-compulsive behavior (HP:0000722)1.72315916
150Papilledema (HP:0001085)1.71181072
151Increased nuchal translucency (HP:0010880)1.70422227
152Inappropriate behavior (HP:0000719)1.69218818
153Hand muscle atrophy (HP:0009130)1.68860257
154Urinary bladder sphincter dysfunction (HP:0002839)1.68788958
155Natal tooth (HP:0000695)1.68130793
156Poor eye contact (HP:0000817)1.67600025
157Aplasia/Hypoplasia of the sternum (HP:0006714)1.67211967
158Truncal ataxia (HP:0002078)1.66124264
159Hypoplasia of the odontoid process (HP:0003311)1.66071841
160Premature skin wrinkling (HP:0100678)1.66067472
161Autism (HP:0000717)1.65582327
162Tented upper lip vermilion (HP:0010804)1.65444559
163Turricephaly (HP:0000262)1.65339959
164Generalized hypotonia (HP:0001290)1.65339854
165Bulbous nose (HP:0000414)1.65135677
166Adducted thumb (HP:0001181)1.65009722
167Increased corneal curvature (HP:0100692)1.64449934
168Keratoconus (HP:0000563)1.64449934
169Spastic gait (HP:0002064)1.62065921
170Protruding tongue (HP:0010808)1.62009597
171Hallux valgus (HP:0001822)1.61772626
172Mild short stature (HP:0003502)1.61309758
173Deviation of the hallux (HP:0010051)1.61205923
174Long palpebral fissure (HP:0000637)1.59842778
175Vitreoretinal degeneration (HP:0000655)1.57251067
176Inguinal hernia (HP:0000023)1.57226269
177Persistence of primary teeth (HP:0006335)1.55737124
178Abnormality of glycosaminoglycan metabolism (HP:0004371)1.55064060
179Abnormality of mucopolysaccharide metabolism (HP:0011020)1.55064060

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.38656720
2NTRK22.85063282
3MAP3K42.59816996
4PKN22.56973407
5KSR12.56599946
6NTRK32.53276014
7MAP3K92.52721405
8MINK12.34019569
9DYRK22.33321009
10ERBB32.30272921
11EPHB22.24406711
12CDK122.13777742
13MAPK132.11023462
14SIK22.08884906
15MAP2K72.07018237
16EPHA21.97657166
17PRKD21.91286514
18PAK61.83748575
19UHMK11.73513202
20TYRO31.72231180
21PHKG11.68845772
22PHKG21.68845772
23SIK31.63745963
24MAP2K41.63617594
25PTK21.56513871
26ERN11.56401840
27ICK1.53795268
28BCR1.52500851
29FGFR41.49945410
30MET1.48571084
31LATS21.45182963
32MST1R1.41521803
33EPHA41.40819057
34WNK41.40786095
35FGFR21.38782373
36MAPKAPK31.35799481
37TTN1.35197270
38MAPK151.32535967
39LMTK21.30996900
40CAMK1G1.30328450
41DDR21.25081733
42LIMK11.24369203
43CHUK1.19908761
44CDK51.17704909
45PAK31.17661885
46DAPK21.16661808
47MARK21.15014139
48PNCK1.13476739
49CASK1.12459156
50PDGFRA1.11527247
51CSNK1G21.09725175
52IRAK31.06751668
53WNK31.05327604
54MAP2K21.03802556
55FRK1.03385263
56MAP3K71.03351367
57MAP3K120.99556325
58PTK60.98242074
59CSNK1A1L0.97301426
60TNK20.97076853
61CDK180.96301211
62MUSK0.95074348
63CSNK1G30.94639261
64CAMKK10.94603320
65ERBB20.94585157
66PRKD30.94351484
67RPS6KA60.93629891
68RPS6KA20.93129843
69DYRK1A0.89671091
70CDK150.86842967
71RET0.86066966
72RPS6KC10.85319635
73RPS6KL10.85319635
74BMPR1B0.84965442
75TNIK0.83472348
76CDK140.82826442
77EEF2K0.82351060
78NTRK10.81735529
79PRKCI0.81520013
80AKT30.79047887
81PRKCH0.77914140
82KSR20.77629140
83ADRBK20.77395155
84EPHB10.76638254
85CDK11A0.75981943
86ALK0.75767238
87MAP3K100.71989299
88RIPK10.71117729
89CAMK1D0.69568242
90FER0.69552767
91WNK10.68279451
92ACVR1B0.67634102
93MAP3K20.66215897
94TGFBR10.66012057
95GRK10.64192685
96CDC42BPA0.63851799
97TRPM70.63468291
98MAPK90.62833484
99ROCK10.61363286
100SMG10.60504081
101CSNK1G10.60199728
102MAP2K60.59940054
103PRKAA10.59030663
104PTK2B0.58859886
105STK110.58841331
106FGFR10.58696996
107PRKCG0.58694104
108MAP2K10.57997294
109INSRR0.57038125
110PRKCZ0.56836773
111PRPF4B0.56494595
112MYLK0.55042902
113PLK20.53347068
114CDK190.52163634
115BMX0.51262925
116IRAK20.51233887
117EPHA30.50421955
118PRKD10.49299265
119TESK10.48083080
120ADRBK10.46070251
121MAPK80.45349037
122ROCK20.44655146
123MAP3K60.44151455
124PIK3CA0.42857413
125GRK50.42796152
126DYRK1B0.42314780
127TRIB30.42136691
128CSNK1E0.41986884
129MTOR0.41436429
130DAPK10.41214808
131SGK2230.40547637
132SGK4940.40547637
133FYN0.39498729
134MAPK100.39195738
135PKN10.39101189
136GSK3B0.38900987
137TAOK10.38234286
138PAK20.38155170
139STK380.37841021
140PRKG20.37198956
141BRD40.36969685
142CSNK1D0.36439808
143SIK10.36279284
144HIPK20.35856739
145CAMK10.35665570
146RPS6KA30.35288571
147FLT30.34669274
148PDGFRB0.34421069
149CAMK2B0.32118404
150MAPK10.31342223
151MAPK110.31094714
152MAPK70.30814477
153PDPK10.30393102

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.82476286
2* Axon guidance_Homo sapiens_hsa043602.46310831
3Synaptic vesicle cycle_Homo sapiens_hsa047212.25467164
4ECM-receptor interaction_Homo sapiens_hsa045122.19280483
5Olfactory transduction_Homo sapiens_hsa047402.06785995
6GABAergic synapse_Homo sapiens_hsa047272.02103080
7Circadian entrainment_Homo sapiens_hsa047131.99491538
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.95701709
9Dopaminergic synapse_Homo sapiens_hsa047281.92787315
10Glutamatergic synapse_Homo sapiens_hsa047241.92178143
11Basal cell carcinoma_Homo sapiens_hsa052171.87122807
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.80690836
13Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.78428474
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.75101995
15Morphine addiction_Homo sapiens_hsa050321.73924285
16Cholinergic synapse_Homo sapiens_hsa047251.71716310
17Colorectal cancer_Homo sapiens_hsa052101.63287396
18Long-term potentiation_Homo sapiens_hsa047201.62458066
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.62177075
20Gap junction_Homo sapiens_hsa045401.61797759
21Hedgehog signaling pathway_Homo sapiens_hsa043401.59488355
22Other glycan degradation_Homo sapiens_hsa005111.56607696
23Endometrial cancer_Homo sapiens_hsa052131.56508407
24Cocaine addiction_Homo sapiens_hsa050301.52653281
25Insulin secretion_Homo sapiens_hsa049111.49568982
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48456629
27Amphetamine addiction_Homo sapiens_hsa050311.47739989
28ErbB signaling pathway_Homo sapiens_hsa040121.45592975
29Taste transduction_Homo sapiens_hsa047421.43260995
30Hippo signaling pathway_Homo sapiens_hsa043901.41896425
31Melanogenesis_Homo sapiens_hsa049161.41758153
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.41144056
33ABC transporters_Homo sapiens_hsa020101.37791458
34Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.37470085
35GnRH signaling pathway_Homo sapiens_hsa049121.37095037
36Serotonergic synapse_Homo sapiens_hsa047261.36740511
37Wnt signaling pathway_Homo sapiens_hsa043101.33797736
38Long-term depression_Homo sapiens_hsa047301.32496174
39Estrogen signaling pathway_Homo sapiens_hsa049151.32364958
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.31210240
41Glioma_Homo sapiens_hsa052141.29904573
42Oxytocin signaling pathway_Homo sapiens_hsa049211.28585666
43Salivary secretion_Homo sapiens_hsa049701.26200574
44Type II diabetes mellitus_Homo sapiens_hsa049301.25542947
45Lysine degradation_Homo sapiens_hsa003101.20428523
46Renin secretion_Homo sapiens_hsa049241.18156510
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.18067776
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.17351504
49Gastric acid secretion_Homo sapiens_hsa049711.17170063
50Protein digestion and absorption_Homo sapiens_hsa049741.15333040
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13712292
52Neurotrophin signaling pathway_Homo sapiens_hsa047221.11226079
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.05781387
54Notch signaling pathway_Homo sapiens_hsa043301.03411167
55Renal cell carcinoma_Homo sapiens_hsa052111.02079742
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01524520
57Oocyte meiosis_Homo sapiens_hsa041140.99702034
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99337132
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.94663313
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93594066
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93581962
62cAMP signaling pathway_Homo sapiens_hsa040240.92106975
63Alcoholism_Homo sapiens_hsa050340.92084824
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90993556
65MAPK signaling pathway_Homo sapiens_hsa040100.90304883
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90055060
67Ovarian steroidogenesis_Homo sapiens_hsa049130.88312675
68mTOR signaling pathway_Homo sapiens_hsa041500.88262957
69Dilated cardiomyopathy_Homo sapiens_hsa054140.86901033
70VEGF signaling pathway_Homo sapiens_hsa043700.86224218
71Calcium signaling pathway_Homo sapiens_hsa040200.86061316
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83600366
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82276824
74Amoebiasis_Homo sapiens_hsa051460.82042190
75PI3K-Akt signaling pathway_Homo sapiens_hsa041510.81582797
76Choline metabolism in cancer_Homo sapiens_hsa052310.81357975
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79576130
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79570473
79Proteoglycans in cancer_Homo sapiens_hsa052050.79058969
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.78935904
81Chronic myeloid leukemia_Homo sapiens_hsa052200.78460628
82Non-small cell lung cancer_Homo sapiens_hsa052230.77743585
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77515853
84Small cell lung cancer_Homo sapiens_hsa052220.76785757
85mRNA surveillance pathway_Homo sapiens_hsa030150.76561973
86Rap1 signaling pathway_Homo sapiens_hsa040150.76243199
87Thyroid hormone synthesis_Homo sapiens_hsa049180.76058207
88Dorso-ventral axis formation_Homo sapiens_hsa043200.75862638
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75708609
90MicroRNAs in cancer_Homo sapiens_hsa052060.75660563
91Acute myeloid leukemia_Homo sapiens_hsa052210.75420979
92Prostate cancer_Homo sapiens_hsa052150.74914786
93Insulin resistance_Homo sapiens_hsa049310.73592484
94Ras signaling pathway_Homo sapiens_hsa040140.72898852
95Insulin signaling pathway_Homo sapiens_hsa049100.72227774
96Lysosome_Homo sapiens_hsa041420.71459610
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70773684
98Inositol phosphate metabolism_Homo sapiens_hsa005620.70263953
99Viral myocarditis_Homo sapiens_hsa054160.69687497
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69595517
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68570160
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68197053
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66749276
104Tight junction_Homo sapiens_hsa045300.65779127
105Pancreatic cancer_Homo sapiens_hsa052120.64868780
106Phototransduction_Homo sapiens_hsa047440.64608352
107Adherens junction_Homo sapiens_hsa045200.63646685
108Bile secretion_Homo sapiens_hsa049760.63484320
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62605692
110Prolactin signaling pathway_Homo sapiens_hsa049170.61795414
111Bladder cancer_Homo sapiens_hsa052190.61038091
112Pathways in cancer_Homo sapiens_hsa052000.60856820
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60727402
114Vibrio cholerae infection_Homo sapiens_hsa051100.60585480
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.60363021
116Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59413583
117Endocytosis_Homo sapiens_hsa041440.59199930
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58331714
119Melanoma_Homo sapiens_hsa052180.58254350
120Focal adhesion_Homo sapiens_hsa045100.57367807
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56745913
122TGF-beta signaling pathway_Homo sapiens_hsa043500.56619366
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.56232307
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53551853
125AMPK signaling pathway_Homo sapiens_hsa041520.51291499

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