PLXNB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)4.81665763
2central nervous system myelination (GO:0022010)4.81665763
3axonal fasciculation (GO:0007413)4.36569764
4layer formation in cerebral cortex (GO:0021819)4.19667714
5neuronal ion channel clustering (GO:0045161)3.96489982
6sodium ion export (GO:0071436)3.86998081
7desmosome organization (GO:0002934)3.78092815
8substrate-independent telencephalic tangential migration (GO:0021826)3.60073790
9substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.60073790
10neuron recognition (GO:0008038)3.45715433
11regulation of apoptotic cell clearance (GO:2000425)3.37628212
12lateral sprouting from an epithelium (GO:0060601)3.23790836
13* semaphorin-plexin signaling pathway (GO:0071526)3.21831451
14cell communication by electrical coupling (GO:0010644)3.20783881
15negative regulation of catenin import into nucleus (GO:0035414)3.17810007
16cell-cell junction maintenance (GO:0045217)3.16382619
17forebrain neuron differentiation (GO:0021879)3.15873475
18dendritic spine morphogenesis (GO:0060997)3.15067431
19regulation of cholesterol biosynthetic process (GO:0045540)3.07202695
20cell migration in hindbrain (GO:0021535)3.06051423
21establishment of nucleus localization (GO:0040023)3.04889478
22establishment of apical/basal cell polarity (GO:0035089)3.04757047
23presynaptic membrane organization (GO:0097090)3.02933004
24locomotory exploration behavior (GO:0035641)3.01727268
25glial cell proliferation (GO:0014009)2.95929894
26lung epithelium development (GO:0060428)2.91021070
27pyrimidine nucleobase catabolic process (GO:0006208)2.84432087
28cerebellar granule cell differentiation (GO:0021707)2.81807237
29response to pheromone (GO:0019236)2.81264792
30protein carboxylation (GO:0018214)2.80645846
31peptidyl-glutamic acid carboxylation (GO:0017187)2.80645846
32proline metabolic process (GO:0006560)2.78035585
33convergent extension (GO:0060026)2.74380722
34cerebral cortex neuron differentiation (GO:0021895)2.72977523
35planar cell polarity pathway involved in neural tube closure (GO:0090179)2.72182889
36cell communication involved in cardiac conduction (GO:0086065)2.69579390
37cell junction maintenance (GO:0034331)2.69033886
38establishment of monopolar cell polarity (GO:0061162)2.68270260
39establishment or maintenance of monopolar cell polarity (GO:0061339)2.68270260
40dendrite morphogenesis (GO:0048813)2.68235231
41regulation of protein activation cascade (GO:2000257)2.64606171
42regulation of neuronal synaptic plasticity (GO:0048168)2.63347712
43vocalization behavior (GO:0071625)2.63065354
44cytoskeletal anchoring at plasma membrane (GO:0007016)2.62868289
45collecting duct development (GO:0072044)2.60773595
46synaptic vesicle docking involved in exocytosis (GO:0016081)2.60276966
47cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.60166860
48regulation of complement activation (GO:0030449)2.59541864
49regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.59086276
50positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.58862661
51insulin-like growth factor receptor signaling pathway (GO:0048009)2.57298104
52cell volume homeostasis (GO:0006884)2.57139361
53peripheral nervous system axon ensheathment (GO:0032292)2.53998450
54myelination in peripheral nervous system (GO:0022011)2.53998450
55ovulation cycle (GO:0042698)2.53336720
56negative regulation of cytosolic calcium ion concentration (GO:0051481)2.53304823
57branching involved in salivary gland morphogenesis (GO:0060445)2.51852115
58regulation of cholesterol homeostasis (GO:2000188)2.49416068
59regulation of axon extension involved in axon guidance (GO:0048841)2.49067212
60multicellular organismal water homeostasis (GO:0050891)2.46472639
61bundle of His cell to Purkinje myocyte communication (GO:0086069)2.46368607
62negative regulation of fibrinolysis (GO:0051918)2.46015229
63regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.45332607
64apical protein localization (GO:0045176)2.45031579
65hemidesmosome assembly (GO:0031581)2.44829905
66cellular potassium ion homeostasis (GO:0030007)2.44055780
67regulation of cholesterol metabolic process (GO:0090181)2.43020013
68proline biosynthetic process (GO:0006561)2.41585371
69neural tube development (GO:0021915)2.41410537
70postsynaptic membrane organization (GO:0001941)2.40205332
71regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.39775099
72cellular response to cholesterol (GO:0071397)2.39723666
73regulation of astrocyte differentiation (GO:0048710)2.39651156
74amino acid import (GO:0043090)2.39166624
75regulation of short-term neuronal synaptic plasticity (GO:0048172)2.38472849
76alpha-linolenic acid metabolic process (GO:0036109)2.37691184
77ventricular cardiac muscle cell action potential (GO:0086005)2.37199123
78ephrin receptor signaling pathway (GO:0048013)2.36250713
79gamma-aminobutyric acid transport (GO:0015812)2.35560608
80regulation of axon guidance (GO:1902667)2.35535923
81epithelial cell differentiation involved in prostate gland development (GO:0060742)2.35088507
82regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.34830331
83midgut development (GO:0007494)2.33548607
84regulation of p38MAPK cascade (GO:1900744)2.33421525
85regulation of synapse maturation (GO:0090128)2.33323371
86auditory behavior (GO:0031223)2.33100748
87cerebellar Purkinje cell differentiation (GO:0021702)2.32983011
88epithelial cell-cell adhesion (GO:0090136)2.32694557
89ethanol oxidation (GO:0006069)2.32540766
90cell-substrate junction assembly (GO:0007044)2.32365389
91negative regulation of lipase activity (GO:0060192)2.32196633
92establishment of planar polarity (GO:0001736)2.32162365
93establishment of tissue polarity (GO:0007164)2.32162365
94synaptic vesicle maturation (GO:0016188)2.32029955
95ethanol metabolic process (GO:0006067)2.31263741
96positive regulation of smoothened signaling pathway (GO:0045880)2.30730444
97notochord development (GO:0030903)2.30426173
98regulation of fibrinolysis (GO:0051917)2.30311481
99high-density lipoprotein particle remodeling (GO:0034375)2.30085997
100positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.29713199
101potassium ion homeostasis (GO:0055075)2.29180602
102sodium ion homeostasis (GO:0055078)2.29109282
103camera-type eye morphogenesis (GO:0048593)2.29029382
104membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.28620346
105peptidyl-tyrosine autophosphorylation (GO:0038083)2.28294082
106positive regulation of synapse maturation (GO:0090129)2.28270044
107neuron cell-cell adhesion (GO:0007158)2.27777570
108adherens junction assembly (GO:0034333)2.27732482
109endothelial cell chemotaxis (GO:0035767)2.27154317
110protein retention in ER lumen (GO:0006621)2.26718874
111axonemal dynein complex assembly (GO:0070286)2.26483369
112potassium ion import (GO:0010107)2.25884112
113triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.25434466
114mating behavior (GO:0007617)2.25351477
115regulation of glutamate receptor signaling pathway (GO:1900449)2.22652550
116reverse cholesterol transport (GO:0043691)2.22556828
117negative regulation of chondrocyte differentiation (GO:0032331)2.21420351
118regulation of ARF GTPase activity (GO:0032312)2.20833138
119renal system development (GO:0072001)2.20792175
120ear development (GO:0043583)2.20718847
121central nervous system projection neuron axonogenesis (GO:0021952)2.20516097
122alanine transport (GO:0032328)2.18868863
123atrioventricular valve morphogenesis (GO:0003181)2.17724517
124negative regulation of sodium ion transport (GO:0010766)2.16950019
125membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.16254103
126embryonic foregut morphogenesis (GO:0048617)2.15800096
127nucleobase catabolic process (GO:0046113)2.14764888
128dendritic spine organization (GO:0097061)2.14600099
129regulation of synapse structural plasticity (GO:0051823)2.13903082
130cellular sodium ion homeostasis (GO:0006883)2.13177486
131neuromuscular process controlling balance (GO:0050885)2.12981593
132negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.12914607
133establishment or maintenance of bipolar cell polarity (GO:0061245)2.12748147
134establishment or maintenance of apical/basal cell polarity (GO:0035088)2.12748147
135dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.12679050
136negative regulation of cholesterol transport (GO:0032375)2.12370026
137negative regulation of sterol transport (GO:0032372)2.12370026
138paraxial mesoderm development (GO:0048339)2.12242831
139plasma lipoprotein particle remodeling (GO:0034369)2.12205202
140protein-lipid complex remodeling (GO:0034368)2.12205202
141macromolecular complex remodeling (GO:0034367)2.12205202
142membrane repolarization (GO:0086009)2.11899277
143lens fiber cell development (GO:0070307)2.11476124
144negative regulation of astrocyte differentiation (GO:0048712)2.11140932
145asymmetric protein localization (GO:0008105)2.09461430
146regulation of heart rate by cardiac conduction (GO:0086091)2.09278720
147regulation of cholesterol esterification (GO:0010872)2.08999510
148response to auditory stimulus (GO:0010996)2.08777317
149regulation of extracellular matrix organization (GO:1903053)2.08738034
150metanephric nephron epithelium development (GO:0072243)2.08465374
151suckling behavior (GO:0001967)2.08384065
152regulation of bile acid biosynthetic process (GO:0070857)2.08291151
153cochlea morphogenesis (GO:0090103)2.08208903
154negative regulation of fatty acid transport (GO:2000192)2.08061770
155metanephric tubule development (GO:0072170)2.08051219
156metanephric nephron tubule development (GO:0072234)2.08051219
157neurotransmitter-gated ion channel clustering (GO:0072578)2.07958846
158Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.06161387
159embryonic retina morphogenesis in camera-type eye (GO:0060059)2.05595894
160skeletal muscle organ development (GO:0060538)2.05170900
161epithelial cell fate commitment (GO:0072148)2.04821803
162positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.04178559
163negative regulation of axon extension involved in axon guidance (GO:0048843)2.03848678
164nucleus localization (GO:0051647)2.01949082
165regulation of membrane repolarization (GO:0060306)2.01582350
166non-canonical Wnt signaling pathway (GO:0035567)2.01514187
167innervation (GO:0060384)2.01491862
168glomerular epithelial cell development (GO:0072310)2.01458152
169regulation of establishment of planar polarity (GO:0090175)2.01060036
170neuromuscular junction development (GO:0007528)2.00351461

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.21876502
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.91763321
3EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56521157
4RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56521157
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.52898419
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.48305710
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.46580179
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.43184231
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37426160
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.35306243
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.34001948
12RNF2_27304074_Chip-Seq_ESCs_Mouse2.26081715
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.24346542
14EZH2_27294783_Chip-Seq_ESCs_Mouse2.13654458
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.12326662
16SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12129338
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.05268416
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.01037772
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.98641286
20DROSHA_22980978_ChIP-Seq_HELA_Human1.98471372
21AR_21572438_ChIP-Seq_LNCaP_Human1.86710519
22ERG_21242973_ChIP-ChIP_JURKAT_Human1.85897129
23PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.80637563
24TP63_17297297_ChIP-ChIP_HaCaT_Human1.79563861
25RACK7_27058665_Chip-Seq_MCF-7_Human1.77975639
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75985389
27ZFP281_18757296_ChIP-ChIP_E14_Mouse1.75870539
28* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.75390944
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69642473
30ZNF263_19887448_ChIP-Seq_K562_Human1.69235298
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69143665
32RING1B_27294783_Chip-Seq_ESCs_Mouse1.66358475
33* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.63141490
34ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.59263703
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.59198010
36SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.59030175
37KDM2B_26808549_Chip-Seq_K562_Human1.56926392
38CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.56340963
39SMC4_20622854_ChIP-Seq_HELA_Human1.54874942
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.54284200
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.53309389
42RING1B_27294783_Chip-Seq_NPCs_Mouse1.51651546
43RUNX1_27514584_Chip-Seq_MCF-7_Human1.50894290
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47154416
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.46538567
46* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.44759904
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43962947
48RARB_27405468_Chip-Seq_BRAIN_Mouse1.43961787
49ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.42807101
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.42274515
51ZFP281_27345836_Chip-Seq_ESCs_Mouse1.42123954
52TP53_20018659_ChIP-ChIP_R1E_Mouse1.41109593
53* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.37970523
54OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.35836603
55GBX2_23144817_ChIP-Seq_PC3_Human1.34899428
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33860408
57REST_21632747_ChIP-Seq_MESCs_Mouse1.33002232
58NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.29284087
59ISL1_27105846_Chip-Seq_CPCs_Mouse1.25750099
60TRIM28_21343339_ChIP-Seq_HEK293_Human1.25253690
61EP300_21415370_ChIP-Seq_HL-1_Mouse1.25179942
62ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24565570
63SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22507226
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22096911
65* P68_20966046_ChIP-Seq_HELA_Human1.22094327
66ARNT_22903824_ChIP-Seq_MCF-7_Human1.20670893
67AHR_22903824_ChIP-Seq_MCF-7_Human1.20030605
68* TET1_21490601_ChIP-Seq_MESCs_Mouse1.19985953
69* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.18893778
70DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16971528
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.16579308
72CTNNB1_20460455_ChIP-Seq_HCT116_Human1.16397109
73REST_18959480_ChIP-ChIP_MESCs_Mouse1.15823265
74ESR1_20079471_ChIP-ChIP_T-47D_Human1.15066843
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14222341
76TP63_22573176_ChIP-Seq_HFKS_Human1.13827984
77RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.13339673
78CTCF_27219007_Chip-Seq_Bcells_Human1.13094449
79* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12029349
80* LXR_22158963_ChIP-Seq_LIVER_Mouse1.11123630
81KDM2B_26808549_Chip-Seq_DND41_Human1.10216252
82CDX2_20551321_ChIP-Seq_CACO-2_Human1.09680407
83EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09076690
84ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08997914
85* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08602302
86PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.08504999
87* RXR_22158963_ChIP-Seq_LIVER_Mouse1.07804364
88SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05689653
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.05460384
90AR_19668381_ChIP-Seq_PC3_Human1.05217133
91KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04186593
92KLF5_25053715_ChIP-Seq_YYC3_Human1.03268482
93IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03155146
94RXR_22108803_ChIP-Seq_LS180_Human1.02971007
95P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01900609
96TCF7_22412390_ChIP-Seq_EML_Mouse1.01696563
97KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01601944
98TP53_23651856_ChIP-Seq_MEFs_Mouse1.01569258
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01232315
100PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00831910
101TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98638639
102LXR_22292898_ChIP-Seq_THP-1_Human0.97923354
103* TP53_22127205_ChIP-Seq_IMR90_Human0.97825427
104TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97812385
105SMAD4_21741376_ChIP-Seq_HESCs_Human0.97003719
106FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.96601444
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95251340
108SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93336144
109ESR1_21235772_ChIP-Seq_MCF-7_Human0.93045683
110* FOXA2_19822575_ChIP-Seq_HepG2_Human0.92948488
111KDM2B_26808549_Chip-Seq_JURKAT_Human0.92117482
112CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89280047
113CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88842775
114THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88398991
115CREB1_26743006_Chip-Seq_LNCaP_Human0.87999853
116PIAS1_25552417_ChIP-Seq_VCAP_Human0.87495842
117RARG_19884340_ChIP-ChIP_MEFs_Mouse0.86778682
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86455783
119BMI1_23680149_ChIP-Seq_NPCS_Mouse0.85538595
120CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85411667
121* SOX2_21211035_ChIP-Seq_LN229_Gbm0.84992470
122CLOCK_20551151_ChIP-Seq_293T_Human0.84813989
123YAP1_20516196_ChIP-Seq_MESCs_Mouse0.84376439
124SMAD3_21741376_ChIP-Seq_EPCs_Human0.83844462
125ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83245045
126PPARA_22158963_ChIP-Seq_LIVER_Mouse0.82395585
127SMAD3_21741376_ChIP-Seq_HESCs_Human0.82011689
128PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82008375
129ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81494579
130NR3C1_21868756_ChIP-Seq_MCF10A_Human0.79743179
131MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.78813516
132NFIB_24661679_ChIP-Seq_LUNG_Mouse0.77213673

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005423_abnormal_somatic_nervous3.57651145
2MP0004859_abnormal_synaptic_plasticity3.15645746
3MP0010030_abnormal_orbit_morphology2.88347934
4MP0002653_abnormal_ependyma_morphology2.72711162
5MP0000778_abnormal_nervous_system2.48933562
6MP0005409_darkened_coat_color2.37174891
7MP0005377_hearing/vestibular/ear_phenot2.13632193
8MP0003878_abnormal_ear_physiology2.13632193
9MP0000566_synostosis2.11378726
10MP0000537_abnormal_urethra_morphology2.07814359
11MP0002234_abnormal_pharynx_morphology2.05494714
12MP0004885_abnormal_endolymph2.02894903
13MP0004858_abnormal_nervous_system1.97822036
14MP0000579_abnormal_nail_morphology1.93662341
15MP0009384_cardiac_valve_regurgitation1.93511186
16MP0003283_abnormal_digestive_organ1.92716991
17MP0009780_abnormal_chondrocyte_physiolo1.85157169
18MP0004270_analgesia1.83073733
19MP0003635_abnormal_synaptic_transmissio1.79357015
20MP0005257_abnormal_intraocular_pressure1.79308130
21MP0002089_abnormal_postnatal_growth/wei1.73197766
22MP0005248_abnormal_Harderian_gland1.71056133
23MP0002254_reproductive_system_inflammat1.68977552
24MP0001346_abnormal_lacrimal_gland1.67197746
25MP0005187_abnormal_penis_morphology1.65601054
26MP0003122_maternal_imprinting1.60513831
27MP0002909_abnormal_adrenal_gland1.54138663
28MP0008995_early_reproductive_senescence1.53551831
29MP0001486_abnormal_startle_reflex1.52257962
30MP0003880_abnormal_central_pattern1.50212536
31MP0002063_abnormal_learning/memory/cond1.49955225
32MP0004264_abnormal_extraembryonic_tissu1.43890055
33MP0005623_abnormal_meninges_morphology1.43211463
34MP0002139_abnormal_hepatobiliary_system1.43080089
35MP0008961_abnormal_basal_metabolism1.40653352
36MP0005076_abnormal_cell_differentiation1.40081093
37MP0010368_abnormal_lymphatic_system1.39230722
38MP0010234_abnormal_vibrissa_follicle1.37068940
39MP0003329_amyloid_beta_deposits1.36585749
40MP0000462_abnormal_digestive_system1.35938308
41MP0010678_abnormal_skin_adnexa1.35628333
42MP0000678_abnormal_parathyroid_gland1.35315212
43MP0000955_abnormal_spinal_cord1.35009384
44MP0000534_abnormal_ureter_morphology1.34926570
45MP0000631_abnormal_neuroendocrine_gland1.32472225
46MP0003705_abnormal_hypodermis_morpholog1.30730792
47MP0003879_abnormal_hair_cell1.29000647
48MP0005645_abnormal_hypothalamus_physiol1.25019406
49MP0004133_heterotaxia1.24889279
50MP0000383_abnormal_hair_follicle1.24503546
51MP0002282_abnormal_trachea_morphology1.24078783
52MP0003115_abnormal_respiratory_system1.20442759
53MP0005646_abnormal_pituitary_gland1.20442399
54MP0003137_abnormal_impulse_conducting1.20223910
55MP0003123_paternal_imprinting1.20011361
56MP0003566_abnormal_cell_adhesion1.19827413
57MP0002249_abnormal_larynx_morphology1.19711749
58MP0002796_impaired_skin_barrier1.17895876
59MP0002064_seizures1.17319593
60MP0009745_abnormal_behavioral_response1.15901946
61MP0003252_abnormal_bile_duct1.15713460
62MP0003453_abnormal_keratinocyte_physiol1.15516186
63MP0002184_abnormal_innervation1.15450516
64* MP0003942_abnormal_urinary_system1.13671225
65MP0003136_yellow_coat_color1.13380707
66MP0003941_abnormal_skin_development1.12809839
67MP0002882_abnormal_neuron_morphology1.12594274
68MP0005394_taste/olfaction_phenotype1.12171221
69MP0005499_abnormal_olfactory_system1.12171221
70MP0002233_abnormal_nose_morphology1.12039309
71MP0001299_abnormal_eye_distance/1.12009689
72MP0008789_abnormal_olfactory_epithelium1.11728671
73MP0001502_abnormal_circadian_rhythm1.11666593
74MP0010329_abnormal_lipoprotein_level1.10051197
75MP0004272_abnormal_basement_membrane1.09064416
76MP0005670_abnormal_white_adipose1.09014034
77MP0009053_abnormal_anal_canal1.07437460
78MP0002697_abnormal_eye_size1.07090066
79MP0003938_abnormal_ear_development1.05850176
80MP0002822_catalepsy1.05759583
81MP0008875_abnormal_xenobiotic_pharmacok1.04936903
82MP0001849_ear_inflammation1.03418493
83MP0002557_abnormal_social/conspecific_i1.01964788
84MP0001666_abnormal_nutrient_absorption1.01937357
85MP0002572_abnormal_emotion/affect_behav1.01804074
86MP0001958_emphysema1.01774448
87MP0002152_abnormal_brain_morphology1.01497071
88MP0005085_abnormal_gallbladder_physiolo1.00258519
89MP0001984_abnormal_olfaction0.99866765
90MP0003861_abnormal_nervous_system0.99689927
91MP0003690_abnormal_glial_cell0.99675117
92MP0004811_abnormal_neuron_physiology0.99067336
93MP0003119_abnormal_digestive_system0.98070281
94MP0002098_abnormal_vibrissa_morphology0.96889862
95MP0000647_abnormal_sebaceous_gland0.95858201
96MP0000467_abnormal_esophagus_morphology0.94076547
97MP0000428_abnormal_craniofacial_morphol0.93909604
98MP0003634_abnormal_glial_cell0.93854753
99MP0000049_abnormal_middle_ear0.93695926
100MP0001177_atelectasis0.93577569
101MP0000762_abnormal_tongue_morphology0.93210658
102MP0008569_lethality_at_weaning0.92613768
103MP0002733_abnormal_thermal_nociception0.89671378
104MP0005360_urolithiasis0.88382190
105MP0004043_abnormal_pH_regulation0.87910938
106MP0003632_abnormal_nervous_system0.87627090
107MP0003935_abnormal_craniofacial_develop0.87479213
108MP0000751_myopathy0.87034069
109MP0005365_abnormal_bile_salt0.86099495
110MP0001348_abnormal_lacrimal_gland0.85439806
111MP0002932_abnormal_joint_morphology0.84113192
112MP0005275_abnormal_skin_tensile0.84063323
113MP0002116_abnormal_craniofacial_bone0.83804098
114MP0009046_muscle_twitch0.83757088
115MP0002896_abnormal_bone_mineralization0.83130805
116MP0001440_abnormal_grooming_behavior0.81659804
117MP0005167_abnormal_blood-brain_barrier0.80442403
118MP0003755_abnormal_palate_morphology0.80441120
119MP0004019_abnormal_vitamin_homeostasis0.80437711
120MP0005083_abnormal_biliary_tract0.80425331
121MP0002734_abnormal_mechanical_nocicepti0.80257937
122MP0002272_abnormal_nervous_system0.79710287
123MP0003385_abnormal_body_wall0.79443654
124MP0000432_abnormal_head_morphology0.78700315
125MP0000026_abnormal_inner_ear0.77856861
126MP0006072_abnormal_retinal_apoptosis0.75325772
127MP0002060_abnormal_skin_morphology0.75321940
128MP0003937_abnormal_limbs/digits/tail_de0.74755648
129MP0002752_abnormal_somatic_nervous0.74693464
130MP0004085_abnormal_heartbeat0.74365355
131MP0002092_abnormal_eye_morphology0.74178094
132MP0006138_congestive_heart_failure0.73392329
133MP0000003_abnormal_adipose_tissue0.72989940
134MP0001485_abnormal_pinna_reflex0.72530110
135MP0004381_abnormal_hair_follicle0.71729807

Predicted human phenotypes

RankGene SetZ-score
1Megalencephaly (HP:0001355)3.63331070
2Aplasia involving bones of the extremities (HP:0009825)3.10905366
3Aplasia involving bones of the upper limbs (HP:0009823)3.10905366
4Aplasia of the phalanges of the hand (HP:0009802)3.10905366
5Coronal craniosynostosis (HP:0004440)2.85414804
6Bronchomalacia (HP:0002780)2.84211203
7Flat acetabular roof (HP:0003180)2.78328671
8Neonatal short-limb short stature (HP:0008921)2.69516811
9Elfin facies (HP:0004428)2.66746045
10Overriding aorta (HP:0002623)2.64996606
11Turricephaly (HP:0000262)2.63452930
12Cerebral aneurysm (HP:0004944)2.61978499
13Insomnia (HP:0100785)2.60959893
14Broad face (HP:0000283)2.59871988
15Cervical subluxation (HP:0003308)2.59542257
16Abnormal eating behavior (HP:0100738)2.57280367
17Renal duplication (HP:0000075)2.57153726
18Complement deficiency (HP:0004431)2.54118843
19Renovascular hypertension (HP:0100817)2.53856833
20Hyperacusis (HP:0010780)2.51835115
21Neurofibrillary tangles (HP:0002185)2.51808886
22Distal upper limb amyotrophy (HP:0007149)2.42803718
23Upper limb amyotrophy (HP:0009129)2.42803718
24Shallow orbits (HP:0000586)2.38319047
25Alacrima (HP:0000522)2.38294539
26Stridor (HP:0010307)2.35777563
27Cerebral inclusion bodies (HP:0100314)2.32984751
28Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.32866403
29Short 4th metacarpal (HP:0010044)2.32866403
30Abnormality of the diencephalon (HP:0010662)2.28580497
31Abnormality of the 4th metacarpal (HP:0010012)2.28254417
32Deep venous thrombosis (HP:0002625)2.27772267
33Broad metatarsal (HP:0001783)2.27390841
34Right ventricular cardiomyopathy (HP:0011663)2.26015677
35Abnormal sex determination (HP:0012244)2.25642831
36Sex reversal (HP:0012245)2.25642831
37Myokymia (HP:0002411)2.25234386
38Fragile nails (HP:0001808)2.22958165
39Ulnar bowing (HP:0003031)2.22417931
40Action tremor (HP:0002345)2.20846757
41Hand muscle atrophy (HP:0009130)2.17277302
42Partial duplication of thumb phalanx (HP:0009944)2.16244814
43Ventricular fibrillation (HP:0001663)2.14764125
44Bell-shaped thorax (HP:0001591)2.11381471
45Lymphangioma (HP:0100764)2.09048441
46Milia (HP:0001056)2.08019641
47Synostosis involving the elbow (HP:0003938)2.07485663
48Humeroradial synostosis (HP:0003041)2.07485663
49Bifid scrotum (HP:0000048)2.07040769
50Abnormality of monocarboxylic acid metabolism (HP:0010996)2.06252557
51Cutaneous finger syndactyly (HP:0010554)2.04020827
52Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.01800438
53Midline defect of the nose (HP:0004122)2.01087694
54Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.99768440
55Laryngomalacia (HP:0001601)1.99606432
56Buphthalmos (HP:0000557)1.99230482
57Abnormality of complement system (HP:0005339)1.97435801
58Pseudobulbar signs (HP:0002200)1.97071682
59Arnold-Chiari malformation (HP:0002308)1.97035677
60Hepatoblastoma (HP:0002884)1.96282481
61Hemorrhage of the eye (HP:0011885)1.95289375
62Supranuclear gaze palsy (HP:0000605)1.95180445
63Absent epiphyses (HP:0010577)1.94954193
64Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.94954193
65Flat cornea (HP:0007720)1.93961074
66Vitreoretinal degeneration (HP:0000655)1.93908146
67Protrusio acetabuli (HP:0003179)1.92658511
68Mixed hearing impairment (HP:0000410)1.90881586
69High anterior hairline (HP:0009890)1.90490845
70Neoplasm of the heart (HP:0100544)1.88729524
71Hypoplastic ischia (HP:0003175)1.87311896
72Epiphyseal dysplasia (HP:0002656)1.85741135
73Atelectasis (HP:0100750)1.85347748
74Abnormality of the middle phalanges of the toes (HP:0010183)1.84508568
75Focal segmental glomerulosclerosis (HP:0000097)1.82756229
76Abnormality of the dental root (HP:0006486)1.82028301
77Taurodontia (HP:0000679)1.82028301
78Abnormality of permanent molar morphology (HP:0011071)1.82028301
79Abnormality of the ischium (HP:0003174)1.81756798
80Pterygium (HP:0001059)1.80104705
81Split foot (HP:0001839)1.79360170
82Cutaneous syndactyly (HP:0012725)1.78778059
83Partial duplication of the phalanx of hand (HP:0009999)1.75654779
84Onycholysis (HP:0001806)1.74921700
85Germ cell neoplasia (HP:0100728)1.74566542
86Visceral angiomatosis (HP:0100761)1.74527495
87Abnormality of molar (HP:0011077)1.73843350
88Abnormality of molar morphology (HP:0011070)1.73843350
89Decreased lacrimation (HP:0000633)1.73361138
90Abnormal respiratory epithelium morphology (HP:0012253)1.72768670
91Abnormal respiratory motile cilium morphology (HP:0005938)1.72768670
92Chorioretinal atrophy (HP:0000533)1.72279361
93Neonatal death (HP:0003811)1.71068926
94Thin bony cortex (HP:0002753)1.71038997
95Abnormal vertebral ossification (HP:0100569)1.70876637
96Vertebral arch anomaly (HP:0008438)1.70471309
97Prolonged partial thromboplastin time (HP:0003645)1.69753617
98Sleep apnea (HP:0010535)1.69234599
99Abnormality of the aortic arch (HP:0012303)1.69031351
100Obsessive-compulsive behavior (HP:0000722)1.68946391
101Atrophic scars (HP:0001075)1.68937602
102Focal seizures (HP:0007359)1.68882283
103Abnormality of the salivary glands (HP:0010286)1.68016327
104Metaphyseal cupping (HP:0003021)1.67813633
105Torticollis (HP:0000473)1.67404045
106Natal tooth (HP:0000695)1.67015610
107Choanal stenosis (HP:0000452)1.66977476
108Esophageal atresia (HP:0002032)1.66727986
109Hypercholesterolemia (HP:0003124)1.66197647
110Pointed chin (HP:0000307)1.65253479
111Glomerulonephritis (HP:0000099)1.64976833
112Abnormality of the dental pulp (HP:0006479)1.64395459
113Hemiparesis (HP:0001269)1.63894655
114Prolonged QT interval (HP:0001657)1.63797335
115Ankyloglossia (HP:0010296)1.63445102
116Glomerulosclerosis (HP:0000096)1.63384053
117Hypoplasia of dental enamel (HP:0006297)1.63362671
118Ventricular arrhythmia (HP:0004308)1.63124481
119Gout (HP:0001997)1.62419102
120Broad palm (HP:0001169)1.61813923
121Trigonocephaly (HP:0000243)1.61507840
122Mitral regurgitation (HP:0001653)1.61034768
123Obstructive sleep apnea (HP:0002870)1.60579344
124Tracheomalacia (HP:0002779)1.60431793
125Tracheal stenosis (HP:0002777)1.59873425
126Chronic bronchitis (HP:0004469)1.58816759
127Biconcave vertebral bodies (HP:0004586)1.57759021
128Termporal pattern (HP:0011008)1.57697157
129Insidious onset (HP:0003587)1.57697157
130Polygenic inheritance (HP:0010982)1.57572872
131Hemangiomatosis (HP:0007461)1.57117692
132Patellar dislocation (HP:0002999)1.56779597
133Back pain (HP:0003418)1.56582819
134Intention tremor (HP:0002080)1.55967832
135Anosmia (HP:0000458)1.55582503
136Pili torti (HP:0003777)1.55442752
137Syncope (HP:0001279)1.54788103
138Xanthomatosis (HP:0000991)1.54522402
139Abnormal ciliary motility (HP:0012262)1.54147704
140Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.53997968
141Hypoplasia of the capital femoral epiphysis (HP:0003090)1.53186827
142Mesangial abnormality (HP:0001966)1.52861380
143Thin ribs (HP:0000883)1.52661088
144Sudden death (HP:0001699)1.51847158
145Severe Myopia (HP:0011003)1.51721154
146Joint hemorrhage (HP:0005261)1.51472588
147Oligodontia (HP:0000677)1.50907359
148Anophthalmia (HP:0000528)1.50550225
149Fragile skin (HP:0001030)1.50297248
150Macroorchidism (HP:0000053)1.50154378
151Precocious puberty (HP:0000826)1.50109618
152Labial hypoplasia (HP:0000066)1.48351961
153Focal motor seizures (HP:0011153)1.46450327
154Morphological abnormality of the middle ear (HP:0008609)1.45799459
155Preaxial foot polydactyly (HP:0001841)1.45071554
156Ankle clonus (HP:0011448)1.42713696
157Genetic anticipation (HP:0003743)1.42247953
158Abnormality of the lower motor neuron (HP:0002366)1.42216046
159Deviation of the hallux (HP:0010051)1.42172060
160Intrahepatic cholestasis (HP:0001406)1.42139355
161Exotropia (HP:0000577)1.41952516
162Wide anterior fontanel (HP:0000260)1.40505715
163Advanced eruption of teeth (HP:0006288)1.40342706
164Truncus arteriosus (HP:0001660)1.39137651
165Abnormality of the antihelix (HP:0009738)1.38946393

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA33.89460476
2EPHB23.02758057
3MST1R2.73368291
4EPHA42.64191733
5RIPK12.46512040
6TRIB32.29678302
7SIK12.23708748
8PAK62.18583894
9MARK12.18087994
10FGFR22.16631316
11LMTK22.16462350
12NTRK22.04399225
13PRKD32.00872473
14KSR11.91385217
15EEF2K1.87461125
16PHKG21.86642784
17PHKG11.86642784
18ICK1.72392241
19NTRK31.65984580
20TYRO31.64043086
21SMG11.63121728
22LATS11.61669511
23PAK31.58932492
24PDGFRA1.46104463
25KSR21.45716594
26IRAK21.36428303
27CDK121.35078259
28CAMK1G1.35007288
29NTRK11.34676589
30FGFR31.34271175
31DAPK21.33066258
32DDR21.29705778
33MAP3K91.28132288
34MAP3K61.27812103
35PTK61.27150362
36CASK1.17519369
37* ERBB21.17076852
38UHMK11.13369561
39FER1.12615022
40SGK2231.10279242
41SGK4941.10279242
42WNK41.06851557
43INSRR1.04529016
44FGFR11.04279173
45MAP3K41.03341737
46BRD41.03188801
47NME11.02821518
48CAMKK11.01464638
49MINK10.97682086
50PRKD20.97155778
51EPHB10.96311221
52FGFR40.96058566
53PKN20.95219354
54ROCK10.94271112
55SIK20.91700220
56CDK50.91015169
57ROCK20.90988196
58MAPK150.90397152
59CAMK1D0.90155454
60RPS6KA20.89703930
61LATS20.89075380
62MAP3K70.88039555
63MAP3K100.87296354
64CDC42BPA0.87186044
65NEK60.82906847
66STK390.82145847
67STK380.82046924
68PRKCZ0.79823573
69SGK30.76999543
70MARK20.76267597
71ERN10.76113005
72DMPK0.75857445
73PTK20.75640291
74SGK20.73028915
75MAP3K20.70516273
76MAP2K40.70150697
77PRKD10.69814625
78BCR0.68513821
79PRKCH0.67906082
80RET0.67175654
81CSNK1A1L0.66820393
82BMX0.65992665
83CSNK1G20.63771409
84PAK20.63481574
85MAPKAPK30.60953104
86TNK20.60774382
87TNIK0.60475329
88PRKAA10.60070313
89PIK3CA0.59324149
90TTN0.57831459
91MTOR0.57242373
92WNK10.55917441
93RPS6KC10.55780300
94RPS6KL10.55780300
95STK110.54655585
96CAMK40.54626664
97PRKAA20.54117615
98PKN10.54041708
99MAPK130.53935326
100STK38L0.52655218
101DYRK1A0.52226655
102TESK10.51989986
103MAPK90.51379450
104GSK3A0.49119085
105MET0.48931745
106SGK10.48463612
107EPHA20.47925166
108PAK40.47732867
109DYRK1B0.47343435
110WNK30.47311805
111IRAK10.46792673
112CAMK2B0.46061222
113PDGFRB0.46042176
114OXSR10.46023502
115CAMK2A0.45790325
116ALK0.45664868
117MAP2K20.45057835
118TAOK10.44956007
119MAP2K10.44521407
120PDPK10.44403956
121CAMK2G0.44308342
122RPS6KA30.44205744
123MAPK80.44088080
124MAPK100.43234653
125SRC0.42940466
126MAP2K60.42394943
127RPS6KA60.41450349
128HIPK20.40398991
129CAMK10.37188845
130RPS6KA10.34451292

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.05873746
2Histidine metabolism_Homo sapiens_hsa003402.32058149
3* Axon guidance_Homo sapiens_hsa043601.86964979
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.79384062
5Cyanoamino acid metabolism_Homo sapiens_hsa004601.79214285
6Phenylalanine metabolism_Homo sapiens_hsa003601.78509926
7Basal cell carcinoma_Homo sapiens_hsa052171.75974314
8Arginine biosynthesis_Homo sapiens_hsa002201.70686393
9Bile secretion_Homo sapiens_hsa049761.63817087
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.63468202
11Primary bile acid biosynthesis_Homo sapiens_hsa001201.55678608
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.48542406
13GABAergic synapse_Homo sapiens_hsa047271.44240894
14Butanoate metabolism_Homo sapiens_hsa006501.36111399
15Circadian entrainment_Homo sapiens_hsa047131.34843081
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.32444876
17Hedgehog signaling pathway_Homo sapiens_hsa043401.31890617
18Gastric acid secretion_Homo sapiens_hsa049711.30312493
19Glutamatergic synapse_Homo sapiens_hsa047241.27444729
20Insulin secretion_Homo sapiens_hsa049111.26978627
21Tyrosine metabolism_Homo sapiens_hsa003501.26043961
22Fatty acid biosynthesis_Homo sapiens_hsa000611.25720521
23Dorso-ventral axis formation_Homo sapiens_hsa043201.25555614
24Fatty acid metabolism_Homo sapiens_hsa012121.25237650
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.25155233
26Nicotine addiction_Homo sapiens_hsa050331.24416316
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23758280
28Salivary secretion_Homo sapiens_hsa049701.20453263
29Hippo signaling pathway_Homo sapiens_hsa043901.18737441
30ABC transporters_Homo sapiens_hsa020101.18122389
31Cocaine addiction_Homo sapiens_hsa050301.17872603
32Melanogenesis_Homo sapiens_hsa049161.17854377
33Fatty acid degradation_Homo sapiens_hsa000711.16735192
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16507294
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15747281
36Vitamin B6 metabolism_Homo sapiens_hsa007501.14920290
37Notch signaling pathway_Homo sapiens_hsa043301.12489633
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.12159734
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.09376948
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.09172422
41Dilated cardiomyopathy_Homo sapiens_hsa054141.08558452
42Lysine degradation_Homo sapiens_hsa003101.08549891
43Arginine and proline metabolism_Homo sapiens_hsa003301.06846420
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02796106
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02162101
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01234541
47Gap junction_Homo sapiens_hsa045400.98192293
48PPAR signaling pathway_Homo sapiens_hsa033200.97795925
49Olfactory transduction_Homo sapiens_hsa047400.97504226
50Glycosaminoglycan degradation_Homo sapiens_hsa005310.96741276
51Retinol metabolism_Homo sapiens_hsa008300.96676173
52Endometrial cancer_Homo sapiens_hsa052130.95230464
53Tryptophan metabolism_Homo sapiens_hsa003800.94758215
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.93812451
55Choline metabolism in cancer_Homo sapiens_hsa052310.93381314
56Morphine addiction_Homo sapiens_hsa050320.92784644
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92538632
58Amphetamine addiction_Homo sapiens_hsa050310.90492482
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90351960
60ECM-receptor interaction_Homo sapiens_hsa045120.90248285
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.88138887
62Type II diabetes mellitus_Homo sapiens_hsa049300.87765728
63Chemical carcinogenesis_Homo sapiens_hsa052040.87636778
64beta-Alanine metabolism_Homo sapiens_hsa004100.86969338
65AMPK signaling pathway_Homo sapiens_hsa041520.86303720
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85777733
67Tight junction_Homo sapiens_hsa045300.85655906
68Cholinergic synapse_Homo sapiens_hsa047250.85514286
69Dopaminergic synapse_Homo sapiens_hsa047280.84655058
70cAMP signaling pathway_Homo sapiens_hsa040240.84000307
71Estrogen signaling pathway_Homo sapiens_hsa049150.83934225
72Other glycan degradation_Homo sapiens_hsa005110.83788077
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83319984
74Pancreatic secretion_Homo sapiens_hsa049720.82076724
75Long-term potentiation_Homo sapiens_hsa047200.81920141
76Renin secretion_Homo sapiens_hsa049240.81914535
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81351592
78Wnt signaling pathway_Homo sapiens_hsa043100.81317546
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79903547
80Insulin signaling pathway_Homo sapiens_hsa049100.79668366
81GnRH signaling pathway_Homo sapiens_hsa049120.76107215
82Complement and coagulation cascades_Homo sapiens_hsa046100.75743659
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73876846
84Oxytocin signaling pathway_Homo sapiens_hsa049210.73275125
85VEGF signaling pathway_Homo sapiens_hsa043700.72575385
86Proteoglycans in cancer_Homo sapiens_hsa052050.71898323
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71772291
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71669400
89Glioma_Homo sapiens_hsa052140.71487519
90Adherens junction_Homo sapiens_hsa045200.71062587
91Renal cell carcinoma_Homo sapiens_hsa052110.70781872
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70321376
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69631079
94Bladder cancer_Homo sapiens_hsa052190.68875941
95Protein digestion and absorption_Homo sapiens_hsa049740.68802479
96Propanoate metabolism_Homo sapiens_hsa006400.68588056
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.67010110
98ErbB signaling pathway_Homo sapiens_hsa040120.66856737
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66655087
100Focal adhesion_Homo sapiens_hsa045100.66645166
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66086583
102Glycerolipid metabolism_Homo sapiens_hsa005610.65686045
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.64944821
104Vitamin digestion and absorption_Homo sapiens_hsa049770.64345358
105Taste transduction_Homo sapiens_hsa047420.63288221
106Inositol phosphate metabolism_Homo sapiens_hsa005620.63233588
107Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63082179
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62916180
109Thyroid hormone synthesis_Homo sapiens_hsa049180.61298024
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.61089597
111Fat digestion and absorption_Homo sapiens_hsa049750.60938033
112Glucagon signaling pathway_Homo sapiens_hsa049220.60551369
113Synaptic vesicle cycle_Homo sapiens_hsa047210.60446297
114Calcium signaling pathway_Homo sapiens_hsa040200.60017571
115Amoebiasis_Homo sapiens_hsa051460.59826241
116Circadian rhythm_Homo sapiens_hsa047100.58999497
117Caffeine metabolism_Homo sapiens_hsa002320.58949278
118Ovarian steroidogenesis_Homo sapiens_hsa049130.58832370
119Rap1 signaling pathway_Homo sapiens_hsa040150.58589607
120Prion diseases_Homo sapiens_hsa050200.58464216
121Insulin resistance_Homo sapiens_hsa049310.57806193
122Sphingolipid metabolism_Homo sapiens_hsa006000.57543861
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56673098
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54423359
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53958952
126Fatty acid elongation_Homo sapiens_hsa000620.52265418
127Long-term depression_Homo sapiens_hsa047300.52222015
128Steroid hormone biosynthesis_Homo sapiens_hsa001400.51916776
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.48919967

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