PLXNB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)4.11516769
2regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.96483676
3regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.87850990
4apoptotic cell clearance (GO:0043277)3.86802322
5COPI coating of Golgi vesicle (GO:0048205)3.58730315
6Golgi transport vesicle coating (GO:0048200)3.58730315
7barbed-end actin filament capping (GO:0051016)3.49434214
8regulation of cholesterol homeostasis (GO:2000188)3.47585782
9cell adhesion mediated by integrin (GO:0033627)3.39165234
10alpha-linolenic acid metabolic process (GO:0036109)3.27525080
11* semaphorin-plexin signaling pathway (GO:0071526)3.26080058
12adherens junction assembly (GO:0034333)3.20543931
13cell-cell junction maintenance (GO:0045217)3.14507303
14regulation of fatty acid beta-oxidation (GO:0031998)3.14382885
15regulation of extracellular matrix disassembly (GO:0010715)3.12845621
16negative regulation of fibrinolysis (GO:0051918)3.12544784
17positive regulation of fatty acid beta-oxidation (GO:0032000)3.09603122
18hemidesmosome assembly (GO:0031581)3.09173294
19activation of Rac GTPase activity (GO:0032863)3.05747124
20epithelial cell-cell adhesion (GO:0090136)3.04303727
21focal adhesion assembly (GO:0048041)3.03839553
22cell-substrate adherens junction assembly (GO:0007045)3.03839553
23retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.02858414
24endothelial cell chemotaxis (GO:0035767)3.02198588
254-hydroxyproline metabolic process (GO:0019471)3.02001151
26protein carboxylation (GO:0018214)2.98370164
27peptidyl-glutamic acid carboxylation (GO:0017187)2.98370164
28negative regulation of fatty acid transport (GO:2000192)2.94831851
29skin morphogenesis (GO:0043589)2.94605534
30positive regulation of receptor recycling (GO:0001921)2.93366209
31basement membrane organization (GO:0071711)2.91531815
32epithelial cell differentiation involved in prostate gland development (GO:0060742)2.90405541
33positive regulation of Cdc42 GTPase activity (GO:0043089)2.89446891
34branching involved in mammary gland duct morphogenesis (GO:0060444)2.89308824
35endodermal cell differentiation (GO:0035987)2.87925124
36activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.86941612
37sulfur amino acid catabolic process (GO:0000098)2.86699519
38regulation of hippo signaling (GO:0035330)2.83165058
39insulin-like growth factor receptor signaling pathway (GO:0048009)2.82824673
40lysine metabolic process (GO:0006553)2.79021463
41lysine catabolic process (GO:0006554)2.79021463
42maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.78111766
43axon extension involved in axon guidance (GO:0048846)2.76394391
44neuron projection extension involved in neuron projection guidance (GO:1902284)2.76394391
45regulation of glucose import in response to insulin stimulus (GO:2001273)2.75623524
46cytoskeletal anchoring at plasma membrane (GO:0007016)2.74592769
47response to laminar fluid shear stress (GO:0034616)2.74145224
48positive regulation of nuclease activity (GO:0032075)2.70897400
49atrioventricular valve morphogenesis (GO:0003181)2.69830359
50negative regulation of erythrocyte differentiation (GO:0045647)2.69052965
51low-density lipoprotein particle clearance (GO:0034383)2.68563889
52positive regulation of p38MAPK cascade (GO:1900745)2.68155359
53apoptotic process involved in morphogenesis (GO:0060561)2.67774808
54hypotonic response (GO:0006971)2.66579531
55triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.66487337
56regulation of early endosome to late endosome transport (GO:2000641)2.65553558
57surfactant homeostasis (GO:0043129)2.64684161
58complement activation, alternative pathway (GO:0006957)2.62863601
59lung epithelium development (GO:0060428)2.62475015
60embryonic retina morphogenesis in camera-type eye (GO:0060059)2.62010528
61positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.60894156
62hippo signaling (GO:0035329)2.60653340
63positive regulation of glycogen biosynthetic process (GO:0045725)2.60105856
64collagen fibril organization (GO:0030199)2.59970323
65pinocytosis (GO:0006907)2.59378188
66positive regulation of extracellular matrix organization (GO:1903055)2.57859329
67vascular endothelial growth factor signaling pathway (GO:0038084)2.57723161
68plasma membrane repair (GO:0001778)2.56564992
69positive regulation of blood vessel endothelial cell migration (GO:0043536)2.56527195
70negative regulation of lipid transport (GO:0032369)2.56320902
71lipoprotein metabolic process (GO:0042157)2.56051094
72Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.55955884
73maternal placenta development (GO:0001893)2.55072385
74negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.54558404
75midgut development (GO:0007494)2.54321519
76L-alpha-amino acid transmembrane transport (GO:1902475)2.52864383
77erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.52343254
78L-phenylalanine catabolic process (GO:0006559)2.52343254
79endoplasmic reticulum unfolded protein response (GO:0030968)2.52229029
80regulation of extracellular matrix organization (GO:1903053)2.52112404
81glyoxylate metabolic process (GO:0046487)2.52061398
82positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.51853512
83protein retention in ER lumen (GO:0006621)2.51783063
84L-phenylalanine metabolic process (GO:0006558)2.51684361
85erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.51684361
86macroautophagy (GO:0016236)2.51657531
87establishment of apical/basal cell polarity (GO:0035089)2.51082293
88cell migration involved in sprouting angiogenesis (GO:0002042)2.50575373
89planar cell polarity pathway involved in neural tube closure (GO:0090179)2.49860751
90regulation of apoptotic process involved in morphogenesis (GO:1902337)2.49805603
91regulation of fibrinolysis (GO:0051917)2.49461355
92negative regulation of cell size (GO:0045792)2.49097682
93fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.48621046
94vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.47921503
95regulation of water loss via skin (GO:0033561)2.47907113
96regulation of apoptotic cell clearance (GO:2000425)2.46885628
97cell-substrate junction assembly (GO:0007044)2.46756675
98urea metabolic process (GO:0019627)2.46435891
99urea cycle (GO:0000050)2.46435891
100regulation of protein activation cascade (GO:2000257)2.46068285
101renal system development (GO:0072001)2.45797210
102regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.45553884
103negative regulation of cholesterol transport (GO:0032375)2.45036783
104negative regulation of sterol transport (GO:0032372)2.45036783
105cell volume homeostasis (GO:0006884)2.44499725
106regulation of cholesterol storage (GO:0010885)2.44323151
107positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.43333831
108regulation of establishment of planar polarity (GO:0090175)2.43038105
109negative regulation of chondrocyte differentiation (GO:0032331)2.41649140
110cellular response to unfolded protein (GO:0034620)2.41046927
111cellular response to vitamin (GO:0071295)2.40024043
112regulation of complement activation (GO:0030449)2.39712276
113cell junction maintenance (GO:0034331)2.39657086
114stress fiber assembly (GO:0043149)2.39134340
115homocysteine metabolic process (GO:0050667)2.38986306
116ER-nucleus signaling pathway (GO:0006984)2.38586969
117regulation of nuclease activity (GO:0032069)2.38060365
118actin filament bundle organization (GO:0061572)2.37912008
119actin filament bundle assembly (GO:0051017)2.37912008
120phospholipid homeostasis (GO:0055091)2.37543832
121regulation of p38MAPK cascade (GO:1900744)2.37536131
122polarized epithelial cell differentiation (GO:0030859)2.36812549
123mannose metabolic process (GO:0006013)2.36433153
124extracellular matrix disassembly (GO:0022617)2.36324938
125membrane protein ectodomain proteolysis (GO:0006509)2.36136911
126cellular response to vitamin D (GO:0071305)2.35745794
127epoxygenase P450 pathway (GO:0019373)2.35418385
128plasma lipoprotein particle clearance (GO:0034381)2.34738765
129COPII vesicle coating (GO:0048208)2.33799095
130adhesion of symbiont to host (GO:0044406)2.33781043
131cellular modified amino acid catabolic process (GO:0042219)2.32734472
132intestinal cholesterol absorption (GO:0030299)2.32144142
133embryonic foregut morphogenesis (GO:0048617)2.31845916
134positive regulation of fatty acid oxidation (GO:0046321)2.31496238
135ear development (GO:0043583)2.31454650
136cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.30997710
137cellular response to nutrient (GO:0031670)2.30519684
138peptide catabolic process (GO:0043171)2.30086811
139Rho protein signal transduction (GO:0007266)2.30054588
140negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.29541509
141reverse cholesterol transport (GO:0043691)2.29104969
142collagen metabolic process (GO:0032963)2.29026531
143gastrulation with mouth forming second (GO:0001702)2.28403248
144protein localization to endosome (GO:0036010)2.28301102
145renal filtration (GO:0097205)2.28107567
146embryo implantation (GO:0007566)2.28046070
147negative regulation of smooth muscle cell migration (GO:0014912)2.27725239
148blood vessel endothelial cell migration (GO:0043534)2.27674149
149protein heterotrimerization (GO:0070208)2.27008869
150dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.26891337
151G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.26482325
152positive regulation of glycogen metabolic process (GO:0070875)2.25428176
153multicellular organismal macromolecule metabolic process (GO:0044259)2.22151193
154amyloid precursor protein catabolic process (GO:0042987)2.21881219
155embryonic process involved in female pregnancy (GO:0060136)2.20930443
156multicellular organismal water homeostasis (GO:0050891)2.20614192
157collagen catabolic process (GO:0030574)2.20308974
158regulation of cholesterol biosynthetic process (GO:0045540)2.20017918
159response to fluid shear stress (GO:0034405)2.18098795
160glomerular basement membrane development (GO:0032836)2.17228538
161virion attachment to host cell (GO:0019062)2.16893213
162adhesion of symbiont to host cell (GO:0044650)2.16893213
163peptidyl-tyrosine autophosphorylation (GO:0038083)2.16491722
164establishment or maintenance of monopolar cell polarity (GO:0061339)2.16365477
165establishment of monopolar cell polarity (GO:0061162)2.16365477
166endocytic recycling (GO:0032456)2.14872536
167negative regulation of viral release from host cell (GO:1902187)2.14732473
168glial cell migration (GO:0008347)2.13118379
169positive regulation of histone deacetylation (GO:0031065)2.12493809

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.85783755
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.37752870
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.38509908
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.30584497
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.13581532
6CLOCK_20551151_ChIP-Seq_293T_Human3.06878168
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.06478625
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.00316672
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.81417764
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.50495026
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.22846955
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.21670247
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.11887037
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.09149274
15* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.03130810
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.00136743
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.96632571
18* VDR_21846776_ChIP-Seq_THP-1_Human1.94280877
19* LXR_22292898_ChIP-Seq_THP-1_Human1.82182751
20* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.80408840
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.80387932
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.80081317
23STAT6_21828071_ChIP-Seq_BEAS2B_Human1.79826677
24RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.78696751
25ZNF263_19887448_ChIP-Seq_K562_Human1.78431367
26TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.70051284
27* ELK3_25401928_ChIP-Seq_HUVEC_Human1.68531457
28* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.65779231
29RACK7_27058665_Chip-Seq_MCF-7_Human1.65186162
30* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.63667087
31* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.62052564
32* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.57034178
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.56758626
34KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.55105823
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.50046793
36HIF1A_21447827_ChIP-Seq_MCF-7_Human1.49938207
37PPAR_26484153_Chip-Seq_NCI-H1993_Human1.48691683
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48187254
39WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.48184418
40SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.47857036
41ZFP281_18757296_ChIP-ChIP_E14_Mouse1.47101161
42CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.46943136
43KDM2B_26808549_Chip-Seq_K562_Human1.46315989
44NFIB_24661679_ChIP-Seq_LUNG_Mouse1.45727423
45ATF3_27146783_Chip-Seq_COLON_Human1.45124587
46* FOXA2_19822575_ChIP-Seq_HepG2_Human1.43625401
47TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40487999
48ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.40215743
49SMC4_20622854_ChIP-Seq_HELA_Human1.39761372
50* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.39550076
51TBX20_22080862_ChIP-Seq_HEART_Mouse1.39135732
52TBX20_22328084_ChIP-Seq_HEART_Mouse1.39135732
53KDM2B_26808549_Chip-Seq_DND41_Human1.37514347
54* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.36372815
55* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.35396505
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.31031434
57* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.31005324
58TCF7_22412390_ChIP-Seq_EML_Mouse1.30662141
59* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.29600794
60* VDR_24763502_ChIP-Seq_THP-1_Human1.27485087
61* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27017321
62ESR1_15608294_ChIP-ChIP_MCF-7_Human1.25825790
63FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.25402391
64SA1_27219007_Chip-Seq_ERYTHROID_Human1.25204653
65CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24957768
66CDX2_20551321_ChIP-Seq_CACO-2_Human1.23920226
67P68_20966046_ChIP-Seq_HELA_Human1.22916801
68GATA6_25053715_ChIP-Seq_YYC3_Human1.22859428
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22342822
70* RUNX1_27514584_Chip-Seq_MCF-7_Human1.22285849
71* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20648464
72* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20040634
73SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18468912
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18428478
75ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18071005
76* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17187254
77SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.16420882
78SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.16420882
79* TET1_21451524_ChIP-Seq_MESCs_Mouse1.16273336
80CJUN_26792858_Chip-Seq_BT549_Human1.14718641
81DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13976826
82ESR1_20079471_ChIP-ChIP_T-47D_Human1.13356728
83ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.12887073
84GATA4_25053715_ChIP-Seq_YYC3_Human1.12752173
85UBF1/2_26484160_Chip-Seq_HMECs_Human1.12011291
86NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11447363
87ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11367681
88* CREB1_26743006_Chip-Seq_LNCaP_Human1.11184504
89EP300_21415370_ChIP-Seq_HL-1_Mouse1.10530955
90TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.10472523
91SALL4_18804426_ChIP-ChIP_XEN_Mouse1.10127857
92KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09742396
93TP63_22573176_ChIP-Seq_HFKS_Human1.09475592
94* SOX2_20726797_ChIP-Seq_SW620_Human1.09303964
95* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06924509
96* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06495690
97KDM2B_26808549_Chip-Seq_JURKAT_Human1.06161149
98ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05258788
99SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04352522
100NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03982668
101VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03673473
102CTCF_27219007_Chip-Seq_Bcells_Human1.03269942
103KLF5_25053715_ChIP-Seq_YYC3_Human1.03120892
104TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02376558
105SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01937208
106ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01646031
107BRD4_25478319_ChIP-Seq_HGPS_Human1.01507699
108ISL1_27105846_Chip-Seq_CPCs_Mouse1.01451598
109TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01215620
110EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00650714
111* TET1_21490601_ChIP-Seq_MESCs_Mouse0.99710881
112NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99683371
113TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99484432
114EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98948957
115SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98685546
116* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97930883
117ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97276058
118GATA1_19941827_ChIP-Seq_MEL_Mouse0.96807988
119RUNX1_22412390_ChIP-Seq_EML_Mouse0.95638229
120SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.94833136
121MYC_22102868_ChIP-Seq_BL_Human0.94002789
122* TP53_22127205_ChIP-Seq_IMR90_Human0.92312155
123Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.90697148
124GATA2_21666600_ChIP-Seq_HMVEC_Human0.89045772
125BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89043332

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.49672103
2MP0008438_abnormal_cutaneous_collagen3.45585657
3MP0005360_urolithiasis3.07235743
4MP0002139_abnormal_hepatobiliary_system3.03942450
5MP0003252_abnormal_bile_duct2.65958095
6MP0005275_abnormal_skin_tensile2.32525643
7MP0009840_abnormal_foam_cell2.32412737
8MP0003566_abnormal_cell_adhesion2.23017498
9MP0003300_gastrointestinal_ulcer2.21991318
10MP0005365_abnormal_bile_salt2.20353021
11MP0010234_abnormal_vibrissa_follicle2.19323377
12MP0003283_abnormal_digestive_organ2.17119655
13MP0005409_darkened_coat_color2.09561847
14MP0004272_abnormal_basement_membrane2.04213482
15MP0005085_abnormal_gallbladder_physiolo2.02916959
16MP0005257_abnormal_intraocular_pressure1.93507639
17MP0009053_abnormal_anal_canal1.84316664
18MP0000537_abnormal_urethra_morphology1.82724598
19MP0002877_abnormal_melanocyte_morpholog1.79758151
20MP0001958_emphysema1.79294303
21MP0005076_abnormal_cell_differentiation1.78645445
22MP0005058_abnormal_lysosome_morphology1.71644681
23MP0009384_cardiac_valve_regurgitation1.71326785
24MP0003191_abnormal_cellular_cholesterol1.70599467
25MP0001849_ear_inflammation1.70493246
26MP0008260_abnormal_autophagy1.66997520
27MP0005451_abnormal_body_composition1.65541139
28MP0010352_gastrointestinal_tract_polyps1.64701073
29MP0006054_spinal_hemorrhage1.62116478
30MP0000566_synostosis1.57394726
31MP0008875_abnormal_xenobiotic_pharmacok1.54127775
32MP0005083_abnormal_biliary_tract1.54123908
33MP0003279_aneurysm1.51972850
34MP0002896_abnormal_bone_mineralization1.51263439
35MP0000858_altered_metastatic_potential1.49913435
36MP0010329_abnormal_lipoprotein_level1.46281606
37MP0005623_abnormal_meninges_morphology1.46276598
38MP0000678_abnormal_parathyroid_gland1.46043579
39MP0010030_abnormal_orbit_morphology1.44154158
40MP0002249_abnormal_larynx_morphology1.42832336
41MP0005023_abnormal_wound_healing1.42016711
42MP0001666_abnormal_nutrient_absorption1.37834933
43MP0003115_abnormal_respiratory_system1.32969706
44MP0005501_abnormal_skin_physiology1.32815220
45MP0000579_abnormal_nail_morphology1.29672337
46MP0000733_abnormal_muscle_development1.29061263
47MP0003091_abnormal_cell_migration1.28923706
48MP0002060_abnormal_skin_morphology1.24919126
49MP0005503_abnormal_tendon_morphology1.24356047
50MP0004947_skin_inflammation1.23357567
51MP0001348_abnormal_lacrimal_gland1.22755428
52MP0010368_abnormal_lymphatic_system1.21591878
53MP0002234_abnormal_pharynx_morphology1.20151996
54MP0000751_myopathy1.19723031
55MP0002098_abnormal_vibrissa_morphology1.17034053
56MP0005220_abnormal_exocrine_pancreas1.16039124
57MP0000534_abnormal_ureter_morphology1.15545359
58MP0003195_calcinosis1.14653319
59MP0002138_abnormal_hepatobiliary_system1.14611277
60MP0003436_decreased_susceptibility_to1.14027139
61MP0002998_abnormal_bone_remodeling1.13824391
62MP0005248_abnormal_Harderian_gland1.11939801
63MP0002928_abnormal_bile_duct1.11032322
64MP0004782_abnormal_surfactant_physiolog1.09630712
65MP0001216_abnormal_epidermal_layer1.08312852
66MP0003329_amyloid_beta_deposits1.07168287
67MP0000767_abnormal_smooth_muscle1.06904813
68MP0002168_other_aberrant_phenotype1.06482908
69MP0004858_abnormal_nervous_system1.05295037
70MP0003172_abnormal_lysosome_physiology1.04686481
71MP0002254_reproductive_system_inflammat1.03482976
72MP0004019_abnormal_vitamin_homeostasis1.01766706
73MP0000609_abnormal_liver_physiology1.01564594
74MP0000762_abnormal_tongue_morphology1.01524519
75MP0000467_abnormal_esophagus_morphology1.01393926
76MP0003045_fibrosis1.01327655
77MP0009780_abnormal_chondrocyte_physiolo1.00749851
78MP0003942_abnormal_urinary_system1.00427099
79MP0001915_intracranial_hemorrhage0.98947052
80MP0005508_abnormal_skeleton_morphology0.97819441
81MP0009643_abnormal_urine_homeostasis0.97372917
82MP0002092_abnormal_eye_morphology0.95995115
83MP0002697_abnormal_eye_size0.94353307
84MP0004185_abnormal_adipocyte_glucose0.94154079
85MP0000428_abnormal_craniofacial_morphol0.94010244
86MP0000569_abnormal_digit_pigmentation0.92696275
87MP0000462_abnormal_digestive_system0.92183288
88MP0003183_abnormal_peptide_metabolism0.91716125
89MP0003453_abnormal_keratinocyte_physiol0.91198498
90MP0004264_abnormal_extraembryonic_tissu0.90466798
91MP0005390_skeleton_phenotype0.89569526
92MP0002282_abnormal_trachea_morphology0.88722702
93MP0003941_abnormal_skin_development0.87400747
94MP0008961_abnormal_basal_metabolism0.87152261
95MP0001533_abnormal_skeleton_physiology0.86948937
96MP0010678_abnormal_skin_adnexa0.84755330
97MP0005332_abnormal_amino_acid0.83746007
98MP0000003_abnormal_adipose_tissue0.81542252
99MP0005666_abnormal_adipose_tissue0.81302367
100MP0001542_abnormal_bone_strength0.81263708
101MP0009278_abnormal_bone_marrow0.80603302
102MP0003385_abnormal_body_wall0.80515986
103MP0003075_altered_response_to0.80041989
104MP0002118_abnormal_lipid_homeostasis0.79315460
105MP0005197_abnormal_uvea_morphology0.79148775
106MP0005375_adipose_tissue_phenotype0.79086430
107MP0010771_integument_phenotype0.78268831
108MP0004084_abnormal_cardiac_muscle0.77858686
109MP0000681_abnormal_thyroid_gland0.77857261
110MP0005164_abnormal_response_to0.77601868
111MP0005670_abnormal_white_adipose0.77364924
112MP0000538_abnormal_urinary_bladder0.76448027
113MP0002796_impaired_skin_barrier0.76336547
114MP0003828_pulmonary_edema0.75992219
115MP0010630_abnormal_cardiac_muscle0.75444771
116MP0009931_abnormal_skin_appearance0.75136948
117MP0001299_abnormal_eye_distance/0.74998056
118MP0005187_abnormal_penis_morphology0.74412521
119MP0000163_abnormal_cartilage_morphology0.74337267
120MP0001756_abnormal_urination0.73713474
121MP0000604_amyloidosis0.73285876
122MP0000598_abnormal_liver_morphology0.73025706
123MP0006138_congestive_heart_failure0.72846557
124MP0003303_peritoneal_inflammation0.72818206
125MP0000013_abnormal_adipose_tissue0.72108699
126MP0005319_abnormal_enzyme/_coenzyme0.72077712
127MP0003448_altered_tumor_morphology0.72027880
128MP0005621_abnormal_cell_physiology0.71500422
129MP0002295_abnormal_pulmonary_circulatio0.71444876
130MP0000377_abnormal_hair_follicle0.71317896
131MP0002135_abnormal_kidney_morphology0.70024092
132MP0004510_myositis0.69988075
133MP0000627_abnormal_mammary_gland0.69977998
134MP0002933_joint_inflammation0.69780477
135MP0004883_abnormal_blood_vessel0.69438199
136MP0001614_abnormal_blood_vessel0.69374815
137MP0002128_abnormal_blood_circulation0.69140382
138MP0002089_abnormal_postnatal_growth/wei0.69044438
139MP0002115_abnormal_skeleton_extremities0.68262276
140MP0001243_abnormal_dermal_layer0.68241967
141MP0001944_abnormal_pancreas_morphology0.67927431
142MP0002113_abnormal_skeleton_development0.67860200
143MP0003795_abnormal_bone_structure0.66486071

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)4.03460416
2Protrusio acetabuli (HP:0003179)4.00148753
3Premature rupture of membranes (HP:0001788)3.72788672
4Shallow orbits (HP:0000586)3.72446181
5Deep venous thrombosis (HP:0002625)3.43834771
6Broad face (HP:0000283)3.38743082
7Complement deficiency (HP:0004431)3.00150817
8Atrophic scars (HP:0001075)2.98461678
9Ankle contracture (HP:0006466)2.87707850
10Aortic aneurysm (HP:0004942)2.85373319
11Obstructive sleep apnea (HP:0002870)2.81786549
12Right ventricular cardiomyopathy (HP:0011663)2.78257388
13Mitral valve prolapse (HP:0001634)2.75889778
14Systemic lupus erythematosus (HP:0002725)2.75547294
15Vertebral compression fractures (HP:0002953)2.75428699
16Xanthomatosis (HP:0000991)2.74751559
17Aortic dissection (HP:0002647)2.73542363
18Broad metatarsal (HP:0001783)2.65376412
19Cervical subluxation (HP:0003308)2.65309840
20Aneurysm (HP:0002617)2.62323541
21Lymphangioma (HP:0100764)2.61380660
22Peritonitis (HP:0002586)2.53876300
23Abnormality of complement system (HP:0005339)2.52235101
24Bladder diverticulum (HP:0000015)2.48761548
25Distal lower limb muscle weakness (HP:0009053)2.44779525
26Distal lower limb amyotrophy (HP:0008944)2.41810756
27Urinary glycosaminoglycan excretion (HP:0003541)2.38064217
28Mucopolysacchariduria (HP:0008155)2.38064217
29Hand muscle atrophy (HP:0009130)2.36042295
30Distal upper limb amyotrophy (HP:0007149)2.36034395
31Upper limb amyotrophy (HP:0009129)2.36034395
32Turricephaly (HP:0000262)2.35966814
33Abnormality of monocarboxylic acid metabolism (HP:0010996)2.32584373
34Thin bony cortex (HP:0002753)2.30021282
35Dilatation of the ascending aorta (HP:0005111)2.29573188
36Dysostosis multiplex (HP:0000943)2.24990722
37Glomerulonephritis (HP:0000099)2.24488434
38Blue sclerae (HP:0000592)2.22962898
39Fragile skin (HP:0001030)2.22920013
40Abnormality of mucopolysaccharide metabolism (HP:0011020)2.21187869
41Abnormality of polysaccharide metabolism (HP:0011012)2.21187869
42Abnormality of glycosaminoglycan metabolism (HP:0004371)2.21187869
43Long toe (HP:0010511)2.20981651
44Natal tooth (HP:0000695)2.19583165
45Intrahepatic cholestasis (HP:0001406)2.19569356
46Arterial tortuosity (HP:0005116)2.17984785
47Biconcave vertebral bodies (HP:0004586)2.17336959
48J-shaped sella turcica (HP:0002680)2.16517918
49Stridor (HP:0010307)2.16263942
50Hemorrhage of the eye (HP:0011885)2.14690788
51Myocardial infarction (HP:0001658)2.13238796
52Vascular tortuosity (HP:0004948)2.12911601
53Mitral regurgitation (HP:0001653)2.11382082
54Advanced eruption of teeth (HP:0006288)2.09816008
55Hyperacusis (HP:0010780)2.09465531
56Increased connective tissue (HP:0009025)2.08380168
57Spinal rigidity (HP:0003306)2.07968852
58Nephritis (HP:0000123)2.06545424
59Ulnar bowing (HP:0003031)2.05873036
60Back pain (HP:0003418)2.05758441
61Interstitial pulmonary disease (HP:0006530)2.04754459
62Disproportionate tall stature (HP:0001519)2.03675241
63Abnormality of dentin (HP:0010299)2.03422357
64Skin nodule (HP:0200036)2.02096653
65Spondylolisthesis (HP:0003302)2.01041737
66Nuclear cataract (HP:0100018)2.01025032
67Abnormality of glutamine family amino acid metabolism (HP:0010902)2.00944110
68Focal segmental glomerulosclerosis (HP:0000097)2.00630983
69Flat acetabular roof (HP:0003180)1.99358154
70Joint stiffness (HP:0001387)1.98520437
71Achilles tendon contracture (HP:0001771)1.98107179
72Esophageal varix (HP:0002040)1.96892204
73Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.96429800
74Short 4th metacarpal (HP:0010044)1.96429800
75Short nail (HP:0001799)1.96412575
76Subacute progressive viral hepatitis (HP:0006572)1.92640303
77Striae distensae (HP:0001065)1.92534151
78Genu recurvatum (HP:0002816)1.92324041
79Asymmetric septal hypertrophy (HP:0001670)1.92316157
80Hypoalphalipoproteinemia (HP:0003233)1.91422734
81Hypoglycemic coma (HP:0001325)1.90746589
82Spastic diplegia (HP:0001264)1.90115905
83Joint laxity (HP:0001388)1.89746430
84Abnormality of the acetabulum (HP:0003170)1.89569962
85Deviation of the hallux (HP:0010051)1.89211950
86Coxa vara (HP:0002812)1.87722343
87Absent frontal sinuses (HP:0002688)1.86851937
88Hallux valgus (HP:0001822)1.86132465
89Abnormality of the Achilles tendon (HP:0005109)1.85641879
90Mildly elevated creatine phosphokinase (HP:0008180)1.85522581
91Milia (HP:0001056)1.85082341
92Soft skin (HP:0000977)1.85065323
93Hematochezia (HP:0002573)1.84975887
94Abnormal ossification of hand bones (HP:0005921)1.84624134
95Atelectasis (HP:0100750)1.84434975
96Abnormality of the distal phalanx of the thumb (HP:0009617)1.82350153
97Enlarged penis (HP:0000040)1.81553005
98Abnormality of the nasal mucosa (HP:0000433)1.81212620
99Camptodactyly of toe (HP:0001836)1.81155568
100Abnormality of the common coagulation pathway (HP:0010990)1.80612096
101Increased cerebral lipofuscin (HP:0011813)1.80556688
102Abnormality of carpal bone ossification (HP:0006257)1.80357080
103Abnormality of the 4th metacarpal (HP:0010012)1.80305282
104Abnormality of the thoracic spine (HP:0100711)1.79641211
105Renovascular hypertension (HP:0100817)1.79496507
106Osteolytic defects of the phalanges of the hand (HP:0009771)1.79463517
107Osteolytic defects of the hand bones (HP:0009699)1.79463517
108Abnormality of liposaccharide metabolism (HP:0010968)1.79368407
109Abnormality of glycosphingolipid metabolism (HP:0004343)1.79368407
110Abnormality of glycolipid metabolism (HP:0010969)1.79368407
111Aortic regurgitation (HP:0001659)1.78644233
112Malnutrition (HP:0004395)1.78598180
113Bowel diverticulosis (HP:0005222)1.78213001
114Axonal loss (HP:0003447)1.76834164
115Ketoacidosis (HP:0001993)1.76008390
116Neurofibrillary tangles (HP:0002185)1.75409524
117Glomerulosclerosis (HP:0000096)1.74695678
118Mitral stenosis (HP:0001718)1.74462673
119Bowed forearm bones (HP:0003956)1.73037408
120Bowing of the arm (HP:0006488)1.73037408
121Neonatal short-limb short stature (HP:0008921)1.72625973
122Elbow flexion contracture (HP:0002987)1.71147437
123Cerebral inclusion bodies (HP:0100314)1.70790807
124Wrist flexion contracture (HP:0001239)1.70153576
125Hyperextensible skin (HP:0000974)1.69408145
126Late onset (HP:0003584)1.68263679
127Bronchomalacia (HP:0002780)1.68236379
128Elfin facies (HP:0004428)1.68082835
129Exostoses (HP:0100777)1.67977097
130Ectopia lentis (HP:0001083)1.67200575
131Asymmetry of the thorax (HP:0001555)1.67106923
132Renal duplication (HP:0000075)1.66867989
133Wormian bones (HP:0002645)1.66812466
134Scapular winging (HP:0003691)1.66794623
135Tibial bowing (HP:0002982)1.66659335
136Gout (HP:0001997)1.66129400
137Increased variability in muscle fiber diameter (HP:0003557)1.66059824
138Loss of speech (HP:0002371)1.65288976
139Hydroxyprolinuria (HP:0003080)1.65191191
140Abnormality of proline metabolism (HP:0010907)1.65191191
141Long palpebral fissure (HP:0000637)1.63942923
142Radial bowing (HP:0002986)1.63831616
143Epidermoid cyst (HP:0200040)1.63495781
144Abnormality of the distal phalanges of the toes (HP:0010182)1.63345295
145Spinal cord compression (HP:0002176)1.62398561
146Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.61198842
147Difficulty climbing stairs (HP:0003551)1.60739717
148Abnormal vertebral ossification (HP:0100569)1.59736161

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.92435137
2PKN23.69110177
3ERN13.37183048
4RIPK13.14755925
5TTN2.87305557
6SIK12.75011866
7PTK62.72635557
8SMG12.58393717
9PDGFRA2.47812186
10LATS12.40451085
11EPHB22.28587007
12MAP3K102.24420001
13TGFBR22.15979081
14EPHA22.10557720
15DDR22.06200870
16PAK41.95035530
17PRPF4B1.85226574
18EEF2K1.83127450
19IRAK31.81421955
20PTK21.70612986
21CAMK1D1.68634475
22ICK1.62126177
23FGFR41.60478395
24MAPK151.45781239
25PRKD21.42455114
26MST1R1.41117325
27CAMK1G1.38783227
28MET1.34483375
29PAK21.34253552
30FER1.28962463
31LRRK21.28174809
32MTOR1.26403982
33BMX1.22127122
34DYRK1B1.22126133
35EPHB11.19572252
36MARK21.18942972
37MAP3K61.16234792
38TAOK11.12162023
39CDK121.07929565
40ERBB21.07718238
41CDK61.03180556
42SCYL21.02558881
43MAP2K20.95973751
44LMTK20.94384992
45FRK0.92543040
46INSRR0.91406885
47PDGFRB0.88389766
48MAP3K130.87844895
49TAOK30.87631974
50MAP3K30.87598960
51NEK90.86635615
52PDPK10.85193124
53PAK30.83895455
54STK30.83290852
55NTRK10.82633980
56PASK0.80867957
57MYLK0.80643858
58LATS20.80624994
59DMPK0.79858335
60FGFR10.78205586
61EPHA30.77659473
62MAP3K20.76975569
63CAMKK10.76074193
64RPS6KC10.75594358
65RPS6KL10.75594358
66ZAP700.73189307
67RET0.72923095
68NME20.72466381
69PIM20.71940782
70TAOK20.71940088
71FLT30.71375097
72TESK10.67977123
73MAP3K10.67975959
74STK100.66556698
75BCKDK0.65215040
76FGFR20.65032852
77PRKD30.64822849
78RPS6KA40.62289914
79ERBB40.60646813
80ILK0.60507499
81GSK3A0.58993452
82MAP2K10.57747085
83JAK10.57472450
84TYK20.57157331
85ARAF0.56045228
86PRKD10.55436957
87TBK10.55252792
88CSF1R0.54206861
89RPS6KA20.54081505
90RPS6KA60.53281862
91MAP3K110.52981981
92ROCK10.52897801
93KSR20.52810662
94MAP2K30.52460099
95TNK20.52053126
96CDC42BPA0.51859407
97CHUK0.50848990
98MAP3K140.50250082
99KSR10.49765147
100FGFR30.49031414
101MAPK70.47954416
102MAP3K70.46416571
103TYRO30.43694025
104NEK10.43409942
105EGFR0.43040345
106MAP3K80.40605347
107MAPKAPK20.39498695
108SRC0.38619581
109ROCK20.38264694
110JAK20.37813421
111HIPK20.37753597
112IRAK20.37671034
113WNK40.37440052
114PRKCH0.36903214
115RIPK40.36339818
116TRPM70.34813040
117BLK0.34620071
118TGFBR10.33479162
119CSK0.33095026
120MOS0.33036648
121MAPK110.32659392
122PRKAA10.32304535
123MAPKAPK30.31308475
124CDK90.31264859
125TESK20.30858309
126CDK70.30596757
127STK380.29207434
128PIK3CG0.29186362
129INSR0.28259142
130MATK0.28095438
131STK38L0.27815489
132RPS6KB20.27735173
133PRKG20.27658086

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.56803134
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.29333044
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.05299895
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.01544867
5Complement and coagulation cascades_Homo sapiens_hsa046101.97378857
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.94035783
7Maturity onset diabetes of the young_Homo sapiens_hsa049501.93476072
8Fatty acid degradation_Homo sapiens_hsa000711.77439112
9Staphylococcus aureus infection_Homo sapiens_hsa051501.75580311
10Arginine biosynthesis_Homo sapiens_hsa002201.68957497
11Tryptophan metabolism_Homo sapiens_hsa003801.68838658
12ECM-receptor interaction_Homo sapiens_hsa045121.64041743
13Bile secretion_Homo sapiens_hsa049761.56305038
14Lysine degradation_Homo sapiens_hsa003101.51739140
15Cyanoamino acid metabolism_Homo sapiens_hsa004601.51387648
16Caffeine metabolism_Homo sapiens_hsa002321.47707932
17PPAR signaling pathway_Homo sapiens_hsa033201.43153131
18Focal adhesion_Homo sapiens_hsa045101.40580269
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.39489314
20Adherens junction_Homo sapiens_hsa045201.37241622
21Bladder cancer_Homo sapiens_hsa052191.32137964
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.31599336
23Lysosome_Homo sapiens_hsa041421.31178766
24Selenocompound metabolism_Homo sapiens_hsa004501.30782201
25Acute myeloid leukemia_Homo sapiens_hsa052211.28763119
26Fat digestion and absorption_Homo sapiens_hsa049751.28393371
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25315364
28Fatty acid metabolism_Homo sapiens_hsa012121.23338329
29Proteoglycans in cancer_Homo sapiens_hsa052051.22923918
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21952097
31Amoebiasis_Homo sapiens_hsa051461.19594654
32Chronic myeloid leukemia_Homo sapiens_hsa052201.18905903
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17864665
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17556350
35Fructose and mannose metabolism_Homo sapiens_hsa000511.16990504
36Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.15075923
37Starch and sucrose metabolism_Homo sapiens_hsa005001.14678124
38VEGF signaling pathway_Homo sapiens_hsa043701.13832752
39Sulfur metabolism_Homo sapiens_hsa009201.13037188
40Small cell lung cancer_Homo sapiens_hsa052221.08785835
41Insulin resistance_Homo sapiens_hsa049311.07972704
42Thyroid hormone signaling pathway_Homo sapiens_hsa049191.07946084
43Protein digestion and absorption_Homo sapiens_hsa049741.06085082
44Butanoate metabolism_Homo sapiens_hsa006501.06043167
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.01695323
46Hepatitis C_Homo sapiens_hsa051601.01541017
47Other glycan degradation_Homo sapiens_hsa005111.00716199
48Thyroid cancer_Homo sapiens_hsa052160.99494060
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98557344
50Neurotrophin signaling pathway_Homo sapiens_hsa047220.97087192
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96061117
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95588901
53ABC transporters_Homo sapiens_hsa020100.94132877
54Regulation of actin cytoskeleton_Homo sapiens_hsa048100.94123812
55GnRH signaling pathway_Homo sapiens_hsa049120.93192735
56Prion diseases_Homo sapiens_hsa050200.92129523
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91721587
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.91104003
59Basal cell carcinoma_Homo sapiens_hsa052170.89512492
60Hippo signaling pathway_Homo sapiens_hsa043900.88576920
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87642366
62Chemical carcinogenesis_Homo sapiens_hsa052040.87321754
63Osteoclast differentiation_Homo sapiens_hsa043800.86994563
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86157356
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85508082
66TNF signaling pathway_Homo sapiens_hsa046680.85437338
67ErbB signaling pathway_Homo sapiens_hsa040120.85262207
68Notch signaling pathway_Homo sapiens_hsa043300.84911393
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83288841
70Histidine metabolism_Homo sapiens_hsa003400.82851313
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82646411
72Choline metabolism in cancer_Homo sapiens_hsa052310.82640092
73Pentose phosphate pathway_Homo sapiens_hsa000300.81075921
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80480264
75Vibrio cholerae infection_Homo sapiens_hsa051100.79688863
76Pertussis_Homo sapiens_hsa051330.78236766
77Endometrial cancer_Homo sapiens_hsa052130.77377068
78Prolactin signaling pathway_Homo sapiens_hsa049170.77348899
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76705719
80Endocytosis_Homo sapiens_hsa041440.76575295
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.76075723
82Pancreatic cancer_Homo sapiens_hsa052120.75042646
83Sphingolipid metabolism_Homo sapiens_hsa006000.75028095
84Salmonella infection_Homo sapiens_hsa051320.74388971
85MicroRNAs in cancer_Homo sapiens_hsa052060.73061846
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72829744
87Dilated cardiomyopathy_Homo sapiens_hsa054140.70219379
88Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68800203
89Type II diabetes mellitus_Homo sapiens_hsa049300.68522604
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68161777
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66441410
92Peroxisome_Homo sapiens_hsa041460.66435124
93Inositol phosphate metabolism_Homo sapiens_hsa005620.66173013
94mTOR signaling pathway_Homo sapiens_hsa041500.66151064
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.64846182
96Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64760673
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64210400
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64065253
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63433606
100B cell receptor signaling pathway_Homo sapiens_hsa046620.62988172
101Carbon metabolism_Homo sapiens_hsa012000.62348881
102Thyroid hormone synthesis_Homo sapiens_hsa049180.62191769
103beta-Alanine metabolism_Homo sapiens_hsa004100.62088808
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.61986753
105Phenylalanine metabolism_Homo sapiens_hsa003600.61564459
106Apoptosis_Homo sapiens_hsa042100.61169142
107Tight junction_Homo sapiens_hsa045300.61045866
108Pathways in cancer_Homo sapiens_hsa052000.60859697
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60849496
110Toxoplasmosis_Homo sapiens_hsa051450.60787272
111Rap1 signaling pathway_Homo sapiens_hsa040150.60352464
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.59851598
113* Axon guidance_Homo sapiens_hsa043600.59830168
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.59683355
115Leishmaniasis_Homo sapiens_hsa051400.59662783
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59105542
117Malaria_Homo sapiens_hsa051440.59061509
118Hedgehog signaling pathway_Homo sapiens_hsa043400.58923042
119Mineral absorption_Homo sapiens_hsa049780.58786231
120Hepatitis B_Homo sapiens_hsa051610.58696133
121AMPK signaling pathway_Homo sapiens_hsa041520.58332394
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57532708
123Biosynthesis of amino acids_Homo sapiens_hsa012300.57342302
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57209771
125Influenza A_Homo sapiens_hsa051640.57191455
126Platelet activation_Homo sapiens_hsa046110.57012425
127Propanoate metabolism_Homo sapiens_hsa006400.56914655
128Melanogenesis_Homo sapiens_hsa049160.56185805
129Glioma_Homo sapiens_hsa052140.55781244
130Shigellosis_Homo sapiens_hsa051310.55615566
131Insulin signaling pathway_Homo sapiens_hsa049100.55595355
132Tuberculosis_Homo sapiens_hsa051520.54975921
133Galactose metabolism_Homo sapiens_hsa000520.54843327
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.54111384
135Phagosome_Homo sapiens_hsa041450.52642364
136Tyrosine metabolism_Homo sapiens_hsa003500.52602171
137Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52016884
138Retinol metabolism_Homo sapiens_hsa008300.51280501
139Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50968089
140Vitamin digestion and absorption_Homo sapiens_hsa049770.50572938
141Prostate cancer_Homo sapiens_hsa052150.50414622
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50301812
143Renin-angiotensin system_Homo sapiens_hsa046140.50244352
144Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49662347
145Renal cell carcinoma_Homo sapiens_hsa052110.49481866
146N-Glycan biosynthesis_Homo sapiens_hsa005100.48576426
147Estrogen signaling pathway_Homo sapiens_hsa049150.48532219
148Pyruvate metabolism_Homo sapiens_hsa006200.48493164
149Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47722456
150Non-small cell lung cancer_Homo sapiens_hsa052230.47509644

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