PM20D1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of water loss via skin (GO:0033561)9.25207635
2hair follicle morphogenesis (GO:0031069)9.12009814
3linoleic acid metabolic process (GO:0043651)8.72263524
4intermediate filament cytoskeleton organization (GO:0045104)8.10507590
5intermediate filament-based process (GO:0045103)7.86376305
6long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)7.85757751
7very long-chain fatty acid metabolic process (GO:0000038)7.54166855
8long-chain fatty-acyl-CoA metabolic process (GO:0035336)7.47647340
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.41657278
10L-phenylalanine catabolic process (GO:0006559)7.41657278
11fatty-acyl-CoA biosynthetic process (GO:0046949)7.11721425
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.10522828
13L-phenylalanine metabolic process (GO:0006558)7.10522828
14aromatic amino acid family catabolic process (GO:0009074)6.77077499
15peptide cross-linking (GO:0018149)6.74969607
16epidermis development (GO:0008544)6.39584497
17multicellular organismal water homeostasis (GO:0050891)6.25808607
18triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.22393444
19tryptophan catabolic process (GO:0006569)6.22093736
20indole-containing compound catabolic process (GO:0042436)6.22093736
21indolalkylamine catabolic process (GO:0046218)6.22093736
22keratinocyte proliferation (GO:0043616)6.15163582
23fatty-acyl-CoA metabolic process (GO:0035337)6.05817613
24kynurenine metabolic process (GO:0070189)5.99037134
25acyl-CoA biosynthetic process (GO:0071616)5.93615516
26thioester biosynthetic process (GO:0035384)5.93615516
27glyoxylate metabolic process (GO:0046487)5.89751340
28retinol metabolic process (GO:0042572)5.87965915
29tryptophan metabolic process (GO:0006568)5.86148507
30keratinocyte differentiation (GO:0030216)5.83466466
31bile acid biosynthetic process (GO:0006699)5.79683897
32alpha-linolenic acid metabolic process (GO:0036109)5.53500746
33cysteine metabolic process (GO:0006534)5.52457466
34urea cycle (GO:0000050)5.44265827
35urea metabolic process (GO:0019627)5.44265827
36positive regulation of chemokine secretion (GO:0090197)5.37968760
37high-density lipoprotein particle remodeling (GO:0034375)5.37403513
38hair cycle process (GO:0022405)5.35677973
39molting cycle process (GO:0022404)5.35677973
40serine family amino acid catabolic process (GO:0009071)5.29032401
41negative regulation of fibrinolysis (GO:0051918)5.28357746
42sulfur amino acid catabolic process (GO:0000098)5.26528078
43peptidyl-glutamic acid carboxylation (GO:0017187)5.18370269
44protein carboxylation (GO:0018214)5.18370269
45water homeostasis (GO:0030104)5.18166073
46regulation of fibrinolysis (GO:0051917)5.08470363
47fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.04952788
48bile acid metabolic process (GO:0008206)5.02744308
49nitrogen cycle metabolic process (GO:0071941)5.01093272
50positive regulation of keratinocyte differentiation (GO:0045618)5.00620597
51complement activation, alternative pathway (GO:0006957)4.98130726
52long-chain fatty acid biosynthetic process (GO:0042759)4.97934314
53regulation of protein activation cascade (GO:2000257)4.96960196
54aromatic amino acid family metabolic process (GO:0009072)4.92601208
55homocysteine metabolic process (GO:0050667)4.89465735
56lysine catabolic process (GO:0006554)4.89344879
57lysine metabolic process (GO:0006553)4.89344879
58regulation of chemokine secretion (GO:0090196)4.87418092
59epidermal cell differentiation (GO:0009913)4.87371237
60phosphatidylserine acyl-chain remodeling (GO:0036150)4.80314876
61amino-acid betaine metabolic process (GO:0006577)4.76930749
62reverse cholesterol transport (GO:0043691)4.71919811
63regulation of cholesterol esterification (GO:0010872)4.71601428
64alpha-amino acid catabolic process (GO:1901606)4.68696221
65regulation of triglyceride catabolic process (GO:0010896)4.63583354
66tyrosine metabolic process (GO:0006570)4.63064269
67regulation of complement activation (GO:0030449)4.62189067
68cellular ketone body metabolic process (GO:0046950)4.60839842
69protein-lipid complex remodeling (GO:0034368)4.59399470
70macromolecular complex remodeling (GO:0034367)4.59399470
71plasma lipoprotein particle remodeling (GO:0034369)4.59399470
72acylglycerol homeostasis (GO:0055090)4.53159602
73triglyceride homeostasis (GO:0070328)4.53159602
74negative regulation of sterol transport (GO:0032372)4.51306069
75negative regulation of cholesterol transport (GO:0032375)4.51306069
76lipoxygenase pathway (GO:0019372)4.48754561
77cellular glucuronidation (GO:0052695)4.47323170
78phospholipid efflux (GO:0033700)4.47052354
79phosphatidylinositol acyl-chain remodeling (GO:0036149)4.42243690
80indolalkylamine metabolic process (GO:0006586)4.41081225
81glycine metabolic process (GO:0006544)4.38040846
82bile acid and bile salt transport (GO:0015721)4.36435326
83cellular biogenic amine catabolic process (GO:0042402)4.35132774
84amine catabolic process (GO:0009310)4.35132774
85primary alcohol metabolic process (GO:0034308)4.34752679
86cellular amino acid catabolic process (GO:0009063)4.33480168
87coenzyme catabolic process (GO:0009109)4.31761867
88drug catabolic process (GO:0042737)4.30861807
89serine family amino acid metabolic process (GO:0009069)4.30520677
90imidazole-containing compound metabolic process (GO:0052803)4.27152887
91glutamate metabolic process (GO:0006536)4.26605890
92plasma lipoprotein particle clearance (GO:0034381)4.22127341
93hemidesmosome assembly (GO:0031581)4.19277995
94cellular modified amino acid catabolic process (GO:0042219)4.19099667
95triglyceride biosynthetic process (GO:0019432)4.18649163
96ethanol oxidation (GO:0006069)4.15034517
97benzene-containing compound metabolic process (GO:0042537)4.14928386
98serine family amino acid biosynthetic process (GO:0009070)4.10728372
99cholesterol efflux (GO:0033344)4.06519335
100bundle of His cell to Purkinje myocyte communication (GO:0086069)4.05186808
101dicarboxylic acid biosynthetic process (GO:0043650)4.02733119
102regulation of keratinocyte differentiation (GO:0045616)4.00438841
103uronic acid metabolic process (GO:0006063)4.00276513
104glucuronate metabolic process (GO:0019585)4.00276513
105short-chain fatty acid metabolic process (GO:0046459)3.98253146
106ketone body metabolic process (GO:1902224)3.98193535
107neutral lipid biosynthetic process (GO:0046460)3.95124250
108acylglycerol biosynthetic process (GO:0046463)3.95124250
109low-density lipoprotein particle remodeling (GO:0034374)3.94886349
110aldehyde catabolic process (GO:0046185)3.92067777
111arginine metabolic process (GO:0006525)3.92010582
112regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.90284288
113plasma lipoprotein particle assembly (GO:0034377)3.88711712
114drug transmembrane transport (GO:0006855)3.86883650
115urate metabolic process (GO:0046415)3.86517475
116carboxylic acid catabolic process (GO:0046395)3.83064958
117organic acid catabolic process (GO:0016054)3.83064958
118regulation of bile acid biosynthetic process (GO:0070857)3.79634828
119positive regulation of epidermal cell differentiation (GO:0045606)3.79557253
120fibrinolysis (GO:0042730)3.77650321
121positive regulation of triglyceride lipase activity (GO:0061365)3.73739255
122positive regulation of lipoprotein lipase activity (GO:0051006)3.73739255
123flavonoid metabolic process (GO:0009812)3.73735208
124regulation of sequestering of triglyceride (GO:0010889)3.72364833
125acetyl-CoA metabolic process (GO:0006084)3.71594854
126very-low-density lipoprotein particle assembly (GO:0034379)3.71243657
127regulation of cholesterol homeostasis (GO:2000188)3.70635879
128phospholipid homeostasis (GO:0055091)3.69452528
129cholesterol homeostasis (GO:0042632)3.67830716
130exogenous drug catabolic process (GO:0042738)3.67413471
131cofactor catabolic process (GO:0051187)3.65765971
132positive regulation of lipid catabolic process (GO:0050996)3.63101382
133sterol homeostasis (GO:0055092)3.62673664
134aspartate family amino acid catabolic process (GO:0009068)3.61325053
135blood coagulation, intrinsic pathway (GO:0007597)3.59841034
136negative regulation of lipase activity (GO:0060192)3.57858546
137NAD biosynthetic process (GO:0009435)3.57033630
138monocarboxylic acid catabolic process (GO:0072329)3.55956409
139one-carbon compound transport (GO:0019755)3.55626412
140nicotinamide nucleotide biosynthetic process (GO:0019359)3.55246372
141acyl-CoA metabolic process (GO:0006637)3.54602953
142thioester metabolic process (GO:0035383)3.54602953
143phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.54193769
144response to phenylpropanoid (GO:0080184)3.50208254
145phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.40539125
146defense response to fungus (GO:0050832)3.33861551
147carnitine metabolic process (GO:0009437)3.32942776
148epithelial cell differentiation involved in prostate gland development (GO:0060742)3.31627566
149disruption of cells of other organism (GO:0044364)3.21822817
150killing of cells of other organism (GO:0031640)3.21822817
151positive regulation of epidermis development (GO:0045684)3.14268563
152primary alcohol catabolic process (GO:0034310)3.13920762
153phosphatidylcholine acyl-chain remodeling (GO:0036151)3.10452767
154epithelium development (GO:0060429)3.05800293
155hair cycle (GO:0042633)25.7895410
156molting cycle (GO:0042303)25.7895410
157skin morphogenesis (GO:0043589)2.97265372
158regulation of phospholipase A2 activity (GO:0032429)2.95193833
159adhesion of symbiont to host cell (GO:0044650)2.95041610
160virion attachment to host cell (GO:0019062)2.95041610
161phosphatidylserine metabolic process (GO:0006658)2.92622571
162unsaturated fatty acid biosynthetic process (GO:0006636)2.91790329
163negative regulation of keratinocyte proliferation (GO:0010839)2.91652649
164fatty acid biosynthetic process (GO:0006633)2.91095555
165regulation of epidermal cell differentiation (GO:0045604)2.75240742
166ether lipid metabolic process (GO:0046485)2.70508098
167lateral sprouting from an epithelium (GO:0060601)2.59964500
168hair follicle development (GO:0001942)2.53752231
169alditol phosphate metabolic process (GO:0052646)2.53431021
170ethanol metabolic process (GO:0006067)2.51876565
171adhesion of symbiont to host (GO:0044406)2.51713606
172detection of bacterium (GO:0016045)2.51020503
173positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.47277578
174regulation of keratinocyte proliferation (GO:0010837)2.40630353
175phosphatidic acid biosynthetic process (GO:0006654)2.36191011
176phosphatidic acid metabolic process (GO:0046473)2.36191011
177negative regulation of execution phase of apoptosis (GO:1900118)2.36117998
178polarized epithelial cell differentiation (GO:0030859)2.36016511
179regulation of glucocorticoid metabolic process (GO:0031943)2.31509367
180regulation of epidermis development (GO:0045682)2.26215673
181detection of other organism (GO:0098543)2.21989674
182sphingoid metabolic process (GO:0046519)2.18995157
183lipid storage (GO:0019915)2.17295607
184triglyceride metabolic process (GO:0006641)2.13664658
185response to fungus (GO:0009620)2.11743194
186establishment of planar polarity (GO:0001736)2.09008486
187establishment of tissue polarity (GO:0007164)2.09008486
188diol metabolic process (GO:0034311)2.06768196
189ectoderm development (GO:0007398)2.00588734
190fatty acid elongation (GO:0030497)15.4718135
191intermediate filament organization (GO:0045109)13.2578366
192keratinization (GO:0031424)10.8577437
193establishment of skin barrier (GO:0061436)10.7553650
194desmosome organization (GO:0002934)10.0508023
195monocarboxylic acid biosynthetic process (GO:0072330)1.97474576
196phosphatidylglycerol metabolic process (GO:0046471)1.96562870

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat9.72285083
2RXR_22158963_ChIP-Seq_LIVER_Mouse8.31631064
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.12492613
4EGR1_23403033_ChIP-Seq_LIVER_Mouse6.96312121
5LXR_22158963_ChIP-Seq_LIVER_Mouse6.43602925
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.12558724
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.92837321
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.84822052
9CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.51876813
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.04118259
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.90983094
12P63_26484246_Chip-Seq_KERATINOCYTES_Human3.59617170
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.10910639
14SOX9_24532713_ChIP-Seq_HFSC_Mouse2.43494042
15TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07344978
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.05908993
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.6961362
18TP63_17297297_ChIP-ChIP_HaCaT_Human10.8984861
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97429910
20TP63_22573176_ChIP-Seq_HFKS_Human1.79020324
21TP63_23658742_ChIP-Seq_EP156T_Human1.74777258
22ERG_20517297_ChIP-Seq_VCAP_Human1.73817927
23FOXA2_19822575_ChIP-Seq_HepG2_Human1.60863291
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56506162
25HTT_18923047_ChIP-ChIP_STHdh_Human1.54480824
26BCOR_27268052_Chip-Seq_Bcells_Human1.52559345
27SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.52143982
28SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.52143982
29P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.48716240
30HNF4A_19822575_ChIP-Seq_HepG2_Human1.45915167
31RXR_22108803_ChIP-Seq_LS180_Human1.45680128
32FOXH1_21741376_ChIP-Seq_ESCs_Human1.43683903
33* CTCF_20526341_ChIP-Seq_ESCs_Human1.41428664
34* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.37521136
35SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.36682401
36CLOCK_20551151_ChIP-Seq_293T_Human1.36617657
37E2F1_20622854_ChIP-Seq_HELA_Human1.35418529
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35081115
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30014657
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29888398
41GATA1_22025678_ChIP-Seq_K562_Human1.28209387
42* GATA6_21074721_ChIP-Seq_CACO-2_Human1.27383971
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.23932811
44* BCL6_27268052_Chip-Seq_Bcells_Human1.23050573
45GATA3_24758297_ChIP-Seq_MCF-7_Human1.21673193
46* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.17562946
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13512859
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11994151
49ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11654050
50YY1_22570637_ChIP-Seq_MALME-3M_Human1.11054068
51JARID2_20075857_ChIP-Seq_MESCs_Mouse1.09120499
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.07994051
53P68_20966046_ChIP-Seq_HELA_Human1.06983261
54RACK7_27058665_Chip-Seq_MCF-7_Human1.04245931
55ELK4_26923725_Chip-Seq_MESODERM_Mouse1.03999719
56CTCF_27219007_Chip-Seq_Bcells_Human1.03503028
57PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99741639
58CSB_26484114_Chip-Seq_FIBROBLAST_Human0.98182634
59CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.96763181
60SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96728128
61SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96658247
62FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96463481
63FOXA1_25329375_ChIP-Seq_VCAP_Human0.96463481
64KLF5_25053715_ChIP-Seq_YYC3_Human0.95710648
65KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94824944
66UBF1/2_26484160_Chip-Seq_HMECs_Human0.94717259
67AR_21572438_ChIP-Seq_LNCaP_Human0.93686020
68KAP1_22055183_ChIP-Seq_ESCs_Mouse0.93284834
69SMC4_20622854_ChIP-Seq_HELA_Human0.93174788
70GATA4_25053715_ChIP-Seq_YYC3_Human0.92926557
71RNF2_27304074_Chip-Seq_ESCs_Mouse0.91803146
72STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91694422
73IRF8_22096565_ChIP-ChIP_GC-B_Human0.91408891
74RUNX1_27514584_Chip-Seq_MCF-7_Human0.91247961
75EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.90948606
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90426959
77ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89830410
78ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87941602
79AHR_22903824_ChIP-Seq_MCF-7_Human0.87810040
80PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.86506560
81* HNFA_21074721_ChIP-Seq_CACO-2_Human0.85712696
82RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85078453
83CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83509504
84ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82865415
85AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82220715
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81645363
87Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.81207492
88SCL_19346495_ChIP-Seq_HPC-7_Human0.80874225
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79706594
90* PHF8_20622853_ChIP-Seq_HELA_Human0.77757965
91SMAD4_21741376_ChIP-Seq_ESCs_Human0.77492108
92ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.77284409
93SUZ12_27294783_Chip-Seq_ESCs_Mouse0.77132454
94TBL1_22424771_ChIP-Seq_293T_Human0.76993815
95P300_27268052_Chip-Seq_Bcells_Human0.75928157
96ARNT_22903824_ChIP-Seq_MCF-7_Human0.75685376
97ESR2_21235772_ChIP-Seq_MCF-7_Human0.73365007
98PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.72961407
99* RBPJ_21746931_ChIP-Seq_IB4_Human0.72791240
100RARA_24833708_ChIP-Seq_LIVER_Mouse0.72543793
101TP53_20018659_ChIP-ChIP_R1E_Mouse0.72329522
102* SA1_27219007_Chip-Seq_ERYTHROID_Human0.71430353
103* TBX20_22080862_ChIP-Seq_HEART_Mouse0.71405497
104* TBX20_22328084_ChIP-Seq_HEART_Mouse0.71405497
105NFYB_21822215_ChIP-Seq_K562_Human0.71000500
106AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.70840395
107SOX2_20726797_ChIP-Seq_SW620_Human0.70787071
108PHF8_20622854_ChIP-Seq_HELA_Human0.70345151
109SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.70277714
110OCT4_20526341_ChIP-Seq_ESCs_Human0.70036165
111SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.69596933
112EZH2_27294783_Chip-Seq_ESCs_Mouse0.69467064
113CBX2_22325352_ChIP-Seq_293T-Rex_Human0.69216790
114SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68728250
115NRF2_20460467_ChIP-Seq_MEFs_Mouse0.67860931
116NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.67860931
117* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.67366342
118BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.66315375
119CDX2_20551321_ChIP-Seq_CACO-2_Human0.66284643
120RAD21_21589869_ChIP-Seq_MESCs_Mouse0.66044094
121NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.65985441
122RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.65821000
123ESR1_21235772_ChIP-Seq_MCF-7_Human0.64578341
124CEBPB_22108803_ChIP-Seq_LS180_Human0.61311673
125STAT1_17558387_ChIP-Seq_HELA_Human0.59812303
126AR_20517297_ChIP-Seq_VCAP_Human0.57807382
127GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.57751603
128PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.57367965
129* RARB_24833708_ChIP-Seq_LIVER_Mouse0.57191822
130NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.56575714
131E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.56466465
132ESET_19884257_ChIP-Seq_ESCs_Mouse0.55539221
133NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.54263805
134FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.54134598
135MYC_19915707_ChIP-ChIP_AK7_Human0.53901144
136EGR1_19032775_ChIP-ChIP_M12_Human0.53573526
137FOXA1_25552417_ChIP-Seq_VCAP_Human0.53219328
138STAT3_1855785_ChIP-Seq_MESCs_Mouse0.52501467
139CBP_21632823_ChIP-Seq_H3396_Human0.52437532
140FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.52198634
141* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.50281363
142PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.50224815
143BCAT_22108803_ChIP-Seq_LS180_Human0.48290985
144LXR_22292898_ChIP-Seq_THP-1_Human0.46880131
145PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.46432738
146* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.45882710
147PPAR_26484153_Chip-Seq_NCI-H1993_Human0.45453874
148GATA6_25053715_ChIP-Seq_YYC3_Human0.45264686
149P53_21459846_ChIP-Seq_SAOS-2_Human0.43839591
150ESR1_20079471_ChIP-ChIP_T-47D_Human0.43743692
151* TAF2_19829295_ChIP-Seq_ESCs_Human0.42971100
152EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.42682338
153CDX2_22108803_ChIP-Seq_LS180_Human0.42364022
154FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.41711817
155GATA1_19941827_ChIP-Seq_MEL_Mouse0.41205221
156FOXO3_23340844_ChIP-Seq_DLD1_Human0.40338095
157PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.39917121
158STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.39692230
159TAF15_26573619_Chip-Seq_HEK293_Human0.39428026
160GATA2_19941826_ChIP-Seq_K562_Human0.38954198
161SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.38660422
162FOXH1_21741376_ChIP-Seq_EPCs_Human0.38610872
163ZNF263_19887448_ChIP-Seq_K562_Human0.38436646
164ERG_21242973_ChIP-ChIP_JURKAT_Human0.38034761
165* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.37507090
166MYC_27129775_Chip-Seq_CORNEA_Mouse0.37219986
167CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.36947479
168IRF1_19129219_ChIP-ChIP_H3396_Human0.36693959
169* CRX_20693478_ChIP-Seq_RETINA_Mouse0.36522285
170FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.36450088

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.37310041
2MP0005360_urolithiasis7.82001245
3MP0000647_abnormal_sebaceous_gland6.42705295
4MP0005275_abnormal_skin_tensile6.28488828
5MP0005085_abnormal_gallbladder_physiolo6.27585326
6MP0005365_abnormal_bile_salt6.05765549
7MP0008875_abnormal_xenobiotic_pharmacok5.05188476
8MP0002098_abnormal_vibrissa_morphology5.03304512
9MP0009379_abnormal_foot_pigmentation4.80676123
10MP0010234_abnormal_vibrissa_follicle4.63701112
11MP0003806_abnormal_nucleotide_metabolis4.26966391
12MP0003252_abnormal_bile_duct3.86494680
13MP0005501_abnormal_skin_physiology3.74880187
14MP0001188_hyperpigmentation3.58037774
15MP0005075_abnormal_melanosome_morpholog3.56229814
16MP0010329_abnormal_lipoprotein_level3.48667260
17MP0000377_abnormal_hair_follicle3.45684610
18MP0009840_abnormal_foam_cell3.13988933
19MP0005083_abnormal_biliary_tract2.97289799
20MP0005332_abnormal_amino_acid2.97116949
21MP0003195_calcinosis2.96363868
22MP0004947_skin_inflammation2.83535543
23MP0003453_abnormal_keratinocyte_physiol2.67272550
24MP0001666_abnormal_nutrient_absorption2.63744307
25MP0001216_abnormal_epidermal_layer2.61665941
26MP0010678_abnormal_skin_adnexa2.55724769
27MP0002060_abnormal_skin_morphology2.49882755
28MP0004019_abnormal_vitamin_homeostasis2.43998094
29MP0000383_abnormal_hair_follicle2.42220111
30MP0002095_abnormal_skin_pigmentation2.34055979
31MP0010771_integument_phenotype2.29998154
32MP0003191_abnormal_cellular_cholesterol2.16462815
33MP0002138_abnormal_hepatobiliary_system2.08572493
34MP0000609_abnormal_liver_physiology2.07520626
35MP0002118_abnormal_lipid_homeostasis2.05990080
36MP0000367_abnormal_coat/_hair1.93723732
37MP0003300_gastrointestinal_ulcer1.86582633
38MP0001243_abnormal_dermal_layer1.85939309
39MP0005319_abnormal_enzyme/_coenzyme1.83062120
40MP0000427_abnormal_hair_cycle1.80908711
41MP0003868_abnormal_feces_composition1.78130371
42MP0003878_abnormal_ear_physiology1.71054161
43MP0005377_hearing/vestibular/ear_phenot1.71054161
44MP0005409_darkened_coat_color1.66586863
45MP0001764_abnormal_homeostasis1.64804955
46MP0005451_abnormal_body_composition1.62523479
47MP0009697_abnormal_copulation1.62247085
48MP0005584_abnormal_enzyme/coenzyme_acti1.58376400
49MP0000566_synostosis1.55322366
50MP0009931_abnormal_skin_appearance1.52306615
51MP0000015_abnormal_ear_pigmentation1.42357535
52MP0009643_abnormal_urine_homeostasis1.41919088
53MP0003186_abnormal_redox_activity1.36508195
54MP0004885_abnormal_endolymph1.34635438
55MP0003011_delayed_dark_adaptation1.31609877
56MP0005174_abnormal_tail_pigmentation1.29990556
57MP0005647_abnormal_sex_gland1.15310674
58MP0009764_decreased_sensitivity_to1.12715884
59MP0000598_abnormal_liver_morphology1.10425917
60MP0001191_abnormal_skin_condition1.09250285
61MP0003705_abnormal_hypodermis_morpholog1.08355982
62MP0003656_abnormal_erythrocyte_physiolo1.06931184
63MP0003941_abnormal_skin_development1.06700411
64MP0005636_abnormal_mineral_homeostasis1.05401349
65MP0000467_abnormal_esophagus_morphology1.00753304
66MP0002254_reproductive_system_inflammat0.98475027
67MP0009763_increased_sensitivity_to0.97432552
68MP0000604_amyloidosis0.97402752
69MP0002876_abnormal_thyroid_physiology0.92793177
70MP0010368_abnormal_lymphatic_system0.89888419
71MP0005084_abnormal_gallbladder_morpholo0.87585135
72MP0009642_abnormal_blood_homeostasis0.87444600
73MP0008469_abnormal_protein_level0.87383476
74MP0006036_abnormal_mitochondrial_physio0.86178461
75MP0009780_abnormal_chondrocyte_physiolo0.84135646
76MP0005408_hypopigmentation0.80902357
77MP0005670_abnormal_white_adipose0.80848431
78MP0003763_abnormal_thymus_physiology0.80829622
79MP0002078_abnormal_glucose_homeostasis0.76043153
80MP0009765_abnormal_xenobiotic_induced0.75782824
81MP0005376_homeostasis/metabolism_phenot0.75082804
82MP0001661_extended_life_span0.73482638
83MP0005220_abnormal_exocrine_pancreas0.71645542
84MP0001756_abnormal_urination0.71372546
85MP0002971_abnormal_brown_adipose0.70548549
86MP0005535_abnormal_body_temperature0.68741263
87MP0005334_abnormal_fat_pad0.67914848
88MP0001984_abnormal_olfaction0.64690545
89MP0005266_abnormal_metabolism0.62984548
90MP0009053_abnormal_anal_canal0.62680107
91MP0002136_abnormal_kidney_physiology0.62286312
92MP0004130_abnormal_muscle_cell0.61535220
93MP0003690_abnormal_glial_cell0.61515546
94MP0001851_eye_inflammation0.61434706
95MP0006035_abnormal_mitochondrial_morpho0.57356636
96MP0001784_abnormal_fluid_regulation0.56403972
97MP0005448_abnormal_energy_balance0.55836085
98MP0004782_abnormal_surfactant_physiolog0.54413612
99MP0010030_abnormal_orbit_morphology0.54009929
100MP0003329_amyloid_beta_deposits0.53626598
101MP0004043_abnormal_pH_regulation0.52607759
102MP0002009_preneoplasia0.52167534
103MP0005395_other_phenotype0.52022070
104MP0000639_abnormal_adrenal_gland0.51109124
105MP0002928_abnormal_bile_duct0.49223470
106MP0003638_abnormal_response/metabolism_0.48975602
107MP0003718_maternal_effect0.48376944
108MP0000762_abnormal_tongue_morphology0.48299382
109MP0000465_gastrointestinal_hemorrhage0.47421234
110MP0004858_abnormal_nervous_system0.47057599
111MP0002282_abnormal_trachea_morphology0.46746872
112MP0005503_abnormal_tendon_morphology0.45911331
113MP0005248_abnormal_Harderian_gland0.44539157
114MP0002822_catalepsy0.44273428
115MP0003724_increased_susceptibility_to0.44027320
116MP0005464_abnormal_platelet_physiology0.43910732
117MP0003566_abnormal_cell_adhesion0.43616888
118MP0003953_abnormal_hormone_level0.43314320
119MP0002837_dystrophic_cardiac_calcinosis0.42570496
120MP0008874_decreased_physiological_sensi0.40871906
121MP0005666_abnormal_adipose_tissue0.39323123
122MP0000579_abnormal_nail_morphology0.37454430
123MP0008873_increased_physiological_sensi0.36984284
124MP0002168_other_aberrant_phenotype0.36628607
125MP0005166_decreased_susceptibility_to0.36527743
126MP0006082_CNS_inflammation0.36504213
127MP0003436_decreased_susceptibility_to0.35890945
128MP0003075_altered_response_to0.35484661
129MP0000230_abnormal_systemic_arterial0.35442401
130MP0009672_abnormal_birth_weight0.34853694
131MP0008872_abnormal_physiological_respon0.34374382
132MP0002166_altered_tumor_susceptibility0.34339363
133MP0001765_abnormal_ion_homeostasis0.34176510
134MP0002177_abnormal_outer_ear0.33902657
135MP0002796_impaired_skin_barrier0.33314579
136MP0009115_abnormal_fat_cell0.32360787
137MP0000685_abnormal_immune_system0.30944809
138MP0004381_abnormal_hair_follicle0.30671700
139MP0001853_heart_inflammation0.28963480
140MP0002132_abnormal_respiratory_system0.28701530
141MP0001845_abnormal_inflammatory_respons0.28418071
142MP0000249_abnormal_blood_vessel0.28214384
143MP0001186_pigmentation_phenotype0.26754443
144MP0002970_abnormal_white_adipose0.26433965
145MP0005058_abnormal_lysosome_morphology0.26152344
146MP0009384_cardiac_valve_regurgitation0.26019865
147MP0001919_abnormal_reproductive_system0.26007272
148MP0002135_abnormal_kidney_morphology0.25889812
149MP0000538_abnormal_urinary_bladder0.25446003
150MP0001485_abnormal_pinna_reflex0.24611479
151MP0004264_abnormal_extraembryonic_tissu0.24573480
152MP0002148_abnormal_hypersensitivity_rea0.22915630
153MP0000372_irregular_coat_pigmentation0.22680811
154MP0000627_abnormal_mammary_gland0.21803837
155MP0000462_abnormal_digestive_system0.20595690
156MP0002006_tumorigenesis0.19788756
157MP0005671_abnormal_response_to0.18195820
158MP0001340_abnormal_eyelid_morphology0.17099376
159MP0002163_abnormal_gland_morphology0.16131038
160MP0005023_abnormal_wound_healing0.15831309
161MP0002249_abnormal_larynx_morphology0.15615902
162MP0005646_abnormal_pituitary_gland0.15315170
163MP0004185_abnormal_adipocyte_glucose0.14785482
164MP0009333_abnormal_splenocyte_physiolog0.13519532
165MP0001958_emphysema0.13239158
166MP0002877_abnormal_melanocyte_morpholog0.12986365
167MP0001849_ear_inflammation0.12026474
168MP0002111_abnormal_tail_morphology0.11951652
169MP0008004_abnormal_stomach_pH0.11686790
170MP0005508_abnormal_skeleton_morphology0.09552596
171MP0010386_abnormal_urinary_bladder0.08946790
172MP0010352_gastrointestinal_tract_polyps0.08538153
173MP0004742_abnormal_vestibular_system0.07948937
174MP0000751_myopathy0.06373443
175MP0005452_abnormal_adipose_tissue0.04440428
176MP0003045_fibrosis0.03606020
177MP0000516_abnormal_urinary_system0.02612889

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)9.73241255
2Woolly hair (HP:0002224)9.49438596
3Hypotrichosis (HP:0001006)9.35819746
4Onycholysis (HP:0001806)9.22196412
5Abnormal hair laboratory examination (HP:0003328)7.60988939
6Abnormality of hair growth rate (HP:0011363)7.40710559
7Slow-growing hair (HP:0002217)7.40710559
8Brittle hair (HP:0002299)7.20017301
9Intrahepatic cholestasis (HP:0001406)7.17446056
10Palmoplantar hyperkeratosis (HP:0000972)7.16528500
11Abnormality of aromatic amino acid family metabolism (HP:0004338)7.15951450
12Conjunctival hamartoma (HP:0100780)7.03354698
13Deep venous thrombosis (HP:0002625)7.02154577
14Erythroderma (HP:0001019)6.93651261
15Palmar hyperkeratosis (HP:0010765)6.80428997
16Erythema (HP:0010783)6.43461739
17Abnormality of monocarboxylic acid metabolism (HP:0010996)6.41273278
18Prolonged partial thromboplastin time (HP:0003645)6.24942827
19Hypobetalipoproteinemia (HP:0003563)6.16038055
20Xanthomatosis (HP:0000991)6.04338543
21Plantar hyperkeratosis (HP:0007556)5.80233294
22Absent eyelashes (HP:0000561)5.35666697
23Abnormality of the axillary hair (HP:0100134)5.32342932
24Abnormality of secondary sexual hair (HP:0009888)5.32342932
25Hyperlipoproteinemia (HP:0010980)5.30692991
26Abnormality of nail color (HP:0100643)5.13257650
27Alopecia of scalp (HP:0002293)4.93618261
28Complement deficiency (HP:0004431)4.90464092
29Congenital ichthyosiform erythroderma (HP:0007431)4.80997293
30Hamartoma of the eye (HP:0010568)4.78458835
31Dry hair (HP:0011359)4.73377577
32Joint hemorrhage (HP:0005261)4.72488690
33Hyperglycinemia (HP:0002154)4.70928958
34Hyperammonemia (HP:0001987)4.70546152
35Hypolipoproteinemia (HP:0010981)4.59925049
36Thick nail (HP:0001805)4.53094647
37Hyperglycinuria (HP:0003108)4.49105398
38Abnormality of glutamine family amino acid metabolism (HP:0010902)4.48113130
39Ketosis (HP:0001946)4.40218244
40Abnormality of serine family amino acid metabolism (HP:0010894)4.33206363
41Abnormality of glycine metabolism (HP:0010895)4.33206363
42Abnormality of sulfur amino acid metabolism (HP:0004339)4.27815590
43Epidermoid cyst (HP:0200040)4.26413588
44Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.21313507
45Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.18949099
46Abnormality of aspartate family amino acid metabolism (HP:0010899)4.18228185
47Abnormality of the common coagulation pathway (HP:0010990)4.17256940
48Fat malabsorption (HP:0002630)4.13576148
49Nail dystrophy (HP:0008404)4.07924922
50Absent hair (HP:0002298)4.07005463
51Abnormality of methionine metabolism (HP:0010901)4.02813965
52Hypoalphalipoproteinemia (HP:0003233)3.97983251
53Hypoglycemic coma (HP:0001325)3.97359102
54Absent eyebrow (HP:0002223)3.86347021
55Conjugated hyperbilirubinemia (HP:0002908)3.81352501
56Abnormality of pyrimidine metabolism (HP:0004353)3.79643885
57Sparse eyelashes (HP:0000653)3.72405450
58Fine hair (HP:0002213)3.60798181
59Abnormality of the intrinsic pathway (HP:0010989)3.59608113
60Abnormality of complement system (HP:0005339)3.55988355
61Abnormality of fatty-acid metabolism (HP:0004359)3.55548917
62Hypercholesterolemia (HP:0003124)3.46591909
63Delayed CNS myelination (HP:0002188)3.35153624
64Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.33728057
65Ketoacidosis (HP:0001993)3.33677928
66Abnormal blistering of the skin (HP:0008066)3.30991552
67Hyperbilirubinemia (HP:0002904)3.30592808
68Abnormality of nucleobase metabolism (HP:0010932)3.28061217
69Abnormality of serum amino acid levels (HP:0003112)3.18676152
70Follicular hyperkeratosis (HP:0007502)3.18138675
71Steatorrhea (HP:0002570)3.10028713
72Right ventricular cardiomyopathy (HP:0011663)3.02731738
73Abnormality of purine metabolism (HP:0004352)3.02269883
74Palmoplantar keratoderma (HP:0000982)3.01907074
75Corneal erosion (HP:0200020)2.98783926
76Hepatocellular carcinoma (HP:0001402)2.94631265
77Fragile nails (HP:0001808)2.94196307
78Metabolic acidosis (HP:0001942)2.93470471
79Vascular calcification (HP:0004934)2.90993392
80Abnormality of dicarboxylic acid metabolism (HP:0010995)2.88691976
81Dicarboxylic aciduria (HP:0003215)2.88691976
82Gout (HP:0001997)2.87186552
83Myocardial infarction (HP:0001658)2.86648375
84Hypochromic microcytic anemia (HP:0004840)2.81154146
85Spontaneous abortion (HP:0005268)2.75070037
86Lethargy (HP:0001254)2.74279517
87Sparse scalp hair (HP:0002209)2.66265503
88Parakeratosis (HP:0001036)2.64976847
89Hypergammaglobulinemia (HP:0010702)2.59511445
90Cardiovascular calcification (HP:0011915)2.57308044
91Systemic lupus erythematosus (HP:0002725)2.57096484
92Gangrene (HP:0100758)2.55242541
93Generalized aminoaciduria (HP:0002909)2.54214916
94Hypoglycemic seizures (HP:0002173)2.53534730
95Malnutrition (HP:0004395)2.53495658
96Skin nodule (HP:0200036)2.53437572
97Congenital, generalized hypertrichosis (HP:0004540)2.49852702
98Abnormality of the pupil (HP:0000615)2.48989757
99Cerebral edema (HP:0002181)2.39546685
100Ridged nail (HP:0001807)2.39407921
101Spastic diplegia (HP:0001264)2.38909878
102Acanthocytosis (HP:0001927)2.37681260
103Glomerulonephritis (HP:0000099)2.37547097
104Hypohidrosis (HP:0000966)2.37452316
105Irritability (HP:0000737)2.37221916
106Hamartoma (HP:0010566)2.32219233
107Proximal tubulopathy (HP:0000114)2.30289513
108Neonatal onset (HP:0003623)2.29612660
109Abnormal gallbladder morphology (HP:0012437)2.29131371
110Enlarged kidneys (HP:0000105)2.27650426
111Mitral stenosis (HP:0001718)2.25912973
112Cholelithiasis (HP:0001081)2.24452400
113Abnormality of proline metabolism (HP:0010907)2.24088005
114Hydroxyprolinuria (HP:0003080)2.24088005
115Sensorimotor neuropathy (HP:0007141)2.23933069
116Vomiting (HP:0002013)2.23800834
117Late onset (HP:0003584)2.23462542
118Pancreatitis (HP:0001733)2.22630458
119Blepharitis (HP:0000498)2.21575629
120Milia (HP:0001056)2.20409080
121Esophageal varix (HP:0002040)2.18191399
122Recurrent gram-negative bacterial infections (HP:0005420)2.15850043
123Rickets (HP:0002748)2.14569819
124Abnormal gallbladder physiology (HP:0012438)2.13802676
125Cholecystitis (HP:0001082)2.13802676
126Alkalosis (HP:0001948)2.12015029
127Melanocytic nevus (HP:0000995)2.11996833
128Opisthotonus (HP:0002179)2.10383945
129Renal cortical cysts (HP:0000803)2.08469984
130Menorrhagia (HP:0000132)2.06937010
131Glycosuria (HP:0003076)2.05567008
132Abnormality of urine glucose concentration (HP:0011016)2.05567008
133Hyperinsulinemic hypoglycemia (HP:0000825)2.05326041
134Amyloidosis (HP:0011034)2.04417024
135Gingival bleeding (HP:0000225)2.03405199
136Brushfield spots (HP:0001088)2.03339056
137Abnormality of the salivary glands (HP:0010286)2.03190057
138Hyperuricemia (HP:0002149)2.02752459
139Increased purine levels (HP:0004368)2.02752459
140Acanthosis nigricans (HP:0000956)2.02058659
141Thrombophlebitis (HP:0004418)2.00315149
142Pili torti (HP:0003777)10.9907790
143Abnormal enzyme/coenzyme activity (HP:0012379)1.99504730
144Hypophosphatemic rickets (HP:0004912)1.98434216
145Coarse hair (HP:0002208)1.92212575
146Abnormality of the gallbladder (HP:0005264)1.90541610
147Hemorrhage of the eye (HP:0011885)1.90414069
148Pruritus (HP:0000989)1.89571215
149Poikilocytosis (HP:0004447)1.88242553
150Abnormality of the dental root (HP:0006486)1.84807921
151Taurodontia (HP:0000679)1.84807921
152Abnormality of permanent molar morphology (HP:0011071)1.84807921
153Abnormality of vitamin metabolism (HP:0100508)1.84590521
154Elevated hepatic transaminases (HP:0002910)1.83304095
155Status epilepticus (HP:0002133)1.81382883
156Urticaria (HP:0001025)1.77300950
157Conical tooth (HP:0000698)1.75458247
158Abnormality of molar morphology (HP:0011070)1.75134448
159Abnormality of molar (HP:0011077)1.75134448
160Advanced eruption of teeth (HP:0006288)1.68633530
161Septate vagina (HP:0001153)1.67625805
162Abnormality of the dental pulp (HP:0006479)1.66132295
163Split foot (HP:0001839)1.64254915
164Fatigable weakness (HP:0003473)1.64199577
165Abnormality of the neuromuscular junction (HP:0003398)1.64199577
166Oral leukoplakia (HP:0002745)1.64154098
167Papilloma (HP:0012740)1.61195026
168Verrucae (HP:0200043)1.61195026
169Skin ulcer (HP:0200042)1.56042387
170Natal tooth (HP:0000695)1.54206578
171Furrowed tongue (HP:0000221)1.53502792
172Xerostomia (HP:0000217)1.52915853
173Nasolacrimal duct obstruction (HP:0000579)1.50213188
174Hyperhidrosis (HP:0000975)1.49907865
175Lip pit (HP:0100267)1.40675226
176Aplasia involving bones of the upper limbs (HP:0009823)1.39339778
177Aplasia of the phalanges of the hand (HP:0009802)1.39339778
178Aplasia involving bones of the extremities (HP:0009825)1.39339778
179Hypoplastic labia majora (HP:0000059)1.35837323
180Ventricular tachycardia (HP:0004756)1.34113145
181Oligodontia (HP:0000677)1.30813169
182Abnormality of the labia majora (HP:0012881)1.22873882
183Eczematoid dermatitis (HP:0000976)1.22778609
184Ectropion (HP:0000656)1.19946408
185Multifactorial inheritance (HP:0001426)1.19419687
186Selective tooth agenesis (HP:0001592)1.19352894
187Dry skin (HP:0000958)1.18313416
188Duplicated collecting system (HP:0000081)1.17123749
189Neonatal short-limb short stature (HP:0008921)1.15293822
190Seborrheic dermatitis (HP:0001051)1.14314332
191Dehydration (HP:0001944)1.13299829
192Neonatal death (HP:0003811)1.12983320
193Craniofacial hyperostosis (HP:0004493)1.10506831
194Generalized hyperpigmentation (HP:0007440)1.10203039
195Abnormality of the fingernails (HP:0001231)1.09407184
196Abnormality of the lacrimal duct (HP:0011481)1.09089211
197Breast hypoplasia (HP:0003187)1.02234725
198Ureteral duplication (HP:0000073)0.98055867
199Depressed nasal tip (HP:0000437)0.97926022
200Abnormality of the renal collecting system (HP:0004742)0.97910923

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.36134079
2MAPKAPK35.63390539
3TGFBR15.08116915
4EEF2K5.03810347
5SIK14.53028552
6FGFR44.39506412
7ERN14.12857349
8INSRR3.16797537
9FER2.91192586
10TAOK32.86592927
11ERBB42.57771227
12RPS6KB22.42602845
13STK242.28850958
14MST1R2.28577743
15TRPM72.11947651
16PIK3CG1.99119254
17PRPF4B1.98963637
18MAP2K41.98375368
19MAPKAPK51.94995696
20LATS11.93665467
21FLT31.86950000
22PKN21.83476456
23PINK11.76356259
24MYLK1.75614536
25MAPK111.73700149
26STK391.66752946
27STK38L1.66010284
28DAPK21.61643424
29FGFR11.59939578
30TYK21.59310642
31FRK1.55698551
32NLK1.45002986
33ABL21.36998840
34PTK61.33982274
35NEK91.28944558
36TRIB31.28652096
37MAP3K141.24520388
38IRAK31.22104183
39PRKAA21.21927217
40MAP3K71.16490468
41MAP3K21.13091366
42KIT1.11573276
43FGFR21.10363801
44JAK21.05762431
45KDR1.05634643
46GRK61.04109157
47RPS6KB11.01261989
48JAK10.98885219
49LMTK20.98218648
50MAPKAPK20.96926259
51EIF2AK30.92119581
52TBK10.91793322
53PRKCZ0.90081238
54NEK60.89883512
55MAPK40.88414389
56TIE10.88313118
57ERBB20.85887459
58MAPK70.85358422
59SGK30.84203630
60TESK10.83196077
61IKBKB0.82071630
62MAP2K30.81901393
63LRRK20.81216911
64MET0.79616385
65PRKAA10.78160059
66MAP3K30.77927259
67SGK20.77332285
68MAPK120.75919426
69PRKACG0.75359717
70SMG10.74787792
71TAOK20.74153757
72WNK30.73820359
73MAP3K100.73653313
74DYRK1B0.72341516
75MAP2K60.71444884
76CDK60.70633094
77GSK3A0.70570346
78MARK20.70501616
79CSK0.70259647
80TAOK10.69722466
81GRK10.69632803
82MAPK150.69450372
83MAP3K130.69127750
84WNK40.67844781
85EPHA20.65320512
86CAMK1D0.64825198
87MAP3K110.64727188
88SGK2230.63269735
89SGK4940.63269735
90PDK40.62449144
91PDK30.62449144
92EPHB10.60237006
93RIPK10.60189241
94EPHA30.59112155
95TGFBR20.58927370
96AKT30.58626843
97PBK0.58590556
98MAP3K10.58403853
99IKBKE0.57457753
100PRKD20.57410986
101CAMK2G0.57212719
102EPHA40.53861112
103FGFR30.48299649
104HIPK20.48150670
105PTK20.48013692
106ADRBK10.47656146
107PRKCQ0.45501295
108RET0.43426997
109ITK0.43034547
110IGF1R0.42545789
111ICK0.42252436
112CSF1R0.41236701
113PDPK10.41219681
114MAP3K120.40872739
115CDC42BPA0.40081639
116PDK20.37224096
117CDK40.37150247
118MAP3K50.36579195
119CAMK40.36058208
120NUAK10.35938934
121STK30.35891009
122PRKD10.35343761
123EPHB20.35133677
124CSNK1G10.34873430
125PHKG20.34364958
126PHKG10.34364958
127PRKCG0.33746096
128HCK0.33098086
129SGK10.31948614
130MAP2K10.31693041
131IRAK10.30836166
132IRAK20.30407587
133OXSR10.30396513
134MTOR0.28658940
135ILK0.28590846
136PRKCA0.28126004
137BTK0.28080803
138CDK70.27042791
139MAPK30.27033892
140MAP3K60.26998950
141PKN10.26650636
142JAK30.26589935
143PRKCE0.25791089
144STK380.25737121
145ADRBK20.25016008
146CHUK0.24700249
147PDK10.24180878
148EGFR0.21630729
149MAP2K20.20833519
150ACVR1B0.20698058
151ABL10.20608954
152MAPK90.19083852

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.26248802
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.48922787
3Nitrogen metabolism_Homo sapiens_hsa009103.32037906
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.15056831
5Arginine biosynthesis_Homo sapiens_hsa002202.91263929
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.70876590
7Tryptophan metabolism_Homo sapiens_hsa003802.69748102
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.69179687
9Fatty acid degradation_Homo sapiens_hsa000712.57011935
10Complement and coagulation cascades_Homo sapiens_hsa046102.55098734
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.50487402
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.49683485
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.41114839
14Butanoate metabolism_Homo sapiens_hsa006502.29128344
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.14572101
16Peroxisome_Homo sapiens_hsa041462.13501765
17Propanoate metabolism_Homo sapiens_hsa006402.09494081
18Phototransduction_Homo sapiens_hsa047441.98379344
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.95550920
20Chemical carcinogenesis_Homo sapiens_hsa052041.93202573
21Histidine metabolism_Homo sapiens_hsa003401.93116997
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.92011272
23Sphingolipid metabolism_Homo sapiens_hsa006001.91153470
24Fatty acid metabolism_Homo sapiens_hsa012121.88956596
25PPAR signaling pathway_Homo sapiens_hsa033201.84118671
26beta-Alanine metabolism_Homo sapiens_hsa004101.81352858
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.78823831
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76858167
29Retinol metabolism_Homo sapiens_hsa008301.74820674
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.70240552
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.66076591
32Staphylococcus aureus infection_Homo sapiens_hsa051501.64574235
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.58420620
34Caffeine metabolism_Homo sapiens_hsa002321.57190196
35Selenocompound metabolism_Homo sapiens_hsa004501.52464595
36Phenylalanine metabolism_Homo sapiens_hsa003601.52303635
37Bile secretion_Homo sapiens_hsa049761.51923292
38Pyruvate metabolism_Homo sapiens_hsa006201.44718190
39Sulfur metabolism_Homo sapiens_hsa009201.39668946
40Tyrosine metabolism_Homo sapiens_hsa003501.38608145
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38140031
42Starch and sucrose metabolism_Homo sapiens_hsa005001.35384233
43Fatty acid elongation_Homo sapiens_hsa000621.33732044
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.24548617
45Folate biosynthesis_Homo sapiens_hsa007901.22728878
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.21894495
47Steroid biosynthesis_Homo sapiens_hsa001001.18412373
48Fat digestion and absorption_Homo sapiens_hsa049751.18356731
49ABC transporters_Homo sapiens_hsa020101.17956341
50Carbon metabolism_Homo sapiens_hsa012001.17844835
51Biosynthesis of amino acids_Homo sapiens_hsa012301.15565411
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08633788
53Vitamin digestion and absorption_Homo sapiens_hsa049771.05258652
54Arginine and proline metabolism_Homo sapiens_hsa003301.04703713
55ECM-receptor interaction_Homo sapiens_hsa045121.02271087
56Maturity onset diabetes of the young_Homo sapiens_hsa049501.02037729
57GnRH signaling pathway_Homo sapiens_hsa049121.00443740
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99816668
59Pancreatic secretion_Homo sapiens_hsa049720.99465254
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98489926
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.97035964
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92282456
63Renin secretion_Homo sapiens_hsa049240.90459905
64Sulfur relay system_Homo sapiens_hsa041220.89406741
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88017489
66Vitamin B6 metabolism_Homo sapiens_hsa007500.87970773
67Lysine degradation_Homo sapiens_hsa003100.87626429
68One carbon pool by folate_Homo sapiens_hsa006700.80567033
69Lysosome_Homo sapiens_hsa041420.78690982
70Glycerolipid metabolism_Homo sapiens_hsa005610.73812641
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71770318
72Glutathione metabolism_Homo sapiens_hsa004800.70618089
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63409482
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61734359
75Pentose phosphate pathway_Homo sapiens_hsa000300.57075998
76Fatty acid biosynthesis_Homo sapiens_hsa000610.56320107
77Pertussis_Homo sapiens_hsa051330.53528431
78Collecting duct acid secretion_Homo sapiens_hsa049660.52318826
79VEGF signaling pathway_Homo sapiens_hsa043700.51025779
80Gastric acid secretion_Homo sapiens_hsa049710.50687062
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49138912
82Metabolic pathways_Homo sapiens_hsa011000.48759332
83Glioma_Homo sapiens_hsa052140.48534187
84Salivary secretion_Homo sapiens_hsa049700.48246430
85Serotonergic synapse_Homo sapiens_hsa047260.48118095
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46459792
87Ras signaling pathway_Homo sapiens_hsa040140.44267493
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43584762
89Circadian rhythm_Homo sapiens_hsa047100.39728120
90Long-term potentiation_Homo sapiens_hsa047200.36985746
91Allograft rejection_Homo sapiens_hsa053300.35893320
92Autoimmune thyroid disease_Homo sapiens_hsa053200.35426161
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.35346914
94Tuberculosis_Homo sapiens_hsa051520.34658952
95Graft-versus-host disease_Homo sapiens_hsa053320.34318427
96Melanogenesis_Homo sapiens_hsa049160.34244063
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33951501
98Dorso-ventral axis formation_Homo sapiens_hsa043200.32888508
99Asthma_Homo sapiens_hsa053100.32243342
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31906813
101Fructose and mannose metabolism_Homo sapiens_hsa000510.30489876
102Olfactory transduction_Homo sapiens_hsa047400.30174978
103Long-term depression_Homo sapiens_hsa047300.28826238
104Choline metabolism in cancer_Homo sapiens_hsa052310.28748992
105Aldosterone synthesis and secretion_Homo sapiens_hsa049250.27933833
106Galactose metabolism_Homo sapiens_hsa000520.27393363
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26871148
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.26848529
109Linoleic acid metabolism_Homo sapiens_hsa005910.24173173
110Prion diseases_Homo sapiens_hsa050200.23071285
111Type I diabetes mellitus_Homo sapiens_hsa049400.22781800
112Oxytocin signaling pathway_Homo sapiens_hsa049210.22467229
113Estrogen signaling pathway_Homo sapiens_hsa049150.21551787
114Insulin resistance_Homo sapiens_hsa049310.20100619
115Notch signaling pathway_Homo sapiens_hsa043300.19360307
116Acute myeloid leukemia_Homo sapiens_hsa052210.19050784
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.18896475
118Thyroid cancer_Homo sapiens_hsa052160.17115273
119Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16468715
120Platelet activation_Homo sapiens_hsa046110.15395094
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.14421754
122Amphetamine addiction_Homo sapiens_hsa050310.14353109
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.14012746
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.13984299
125Malaria_Homo sapiens_hsa051440.11749906
126Circadian entrainment_Homo sapiens_hsa047130.10940063
127Focal adhesion_Homo sapiens_hsa045100.08832653
128Glucagon signaling pathway_Homo sapiens_hsa049220.05485870
129Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2584366
130Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2494507
131Ether lipid metabolism_Homo sapiens_hsa00565-0.2392594
132Systemic lupus erythematosus_Homo sapiens_hsa05322-0.2174693
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2009012
134Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1918560
135Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1739962
136Protein digestion and absorption_Homo sapiens_hsa04974-0.1729097
137Hepatitis C_Homo sapiens_hsa05160-0.1710603
138Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1704197
139African trypanosomiasis_Homo sapiens_hsa05143-0.1608763
140Mineral absorption_Homo sapiens_hsa04978-0.1577438
141Insulin signaling pathway_Homo sapiens_hsa04910-0.1371492
142Regulation of autophagy_Homo sapiens_hsa04140-0.1212869
143Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0977280
144Renin-angiotensin system_Homo sapiens_hsa04614-0.0961904
145Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0930368
146Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0692526
147Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0668214
148Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0501751
149Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0370886
150AMPK signaling pathway_Homo sapiens_hsa04152-0.0106149

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