PMAIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1NIK/NF-kappaB signaling (GO:0038061)6.82477251
2regulation of dendritic cell antigen processing and presentation (GO:0002604)5.23284347
3antigen processing and presentation of endogenous antigen (GO:0019883)5.05813522
4regulation of interleukin-12 biosynthetic process (GO:0045075)4.99494321
5ribosome assembly (GO:0042255)4.47537023
6DNA strand elongation involved in DNA replication (GO:0006271)4.28495824
7DNA replication checkpoint (GO:0000076)4.26979051
8response to muramyl dipeptide (GO:0032495)4.22141328
9mitotic metaphase plate congression (GO:0007080)4.13120355
10DNA strand elongation (GO:0022616)4.12429607
11DNA unwinding involved in DNA replication (GO:0006268)4.11900688
12protein localization to kinetochore (GO:0034501)4.04374073
13establishment of integrated proviral latency (GO:0075713)4.03932518
14protein localization to chromosome, centromeric region (GO:0071459)4.00678868
15mitotic sister chromatid segregation (GO:0000070)3.92498122
16myeloid dendritic cell differentiation (GO:0043011)3.88265671
17natural killer cell mediated cytotoxicity (GO:0042267)3.86398314
18natural killer cell mediated immunity (GO:0002228)3.86398314
19telomere maintenance via semi-conservative replication (GO:0032201)3.83162375
20sister chromatid segregation (GO:0000819)3.77580558
21interferon-gamma secretion (GO:0072643)3.76622824
22regulation of DNA endoreduplication (GO:0032875)3.74596514
23growth hormone receptor signaling pathway (GO:0060396)3.71439697
24chromatin remodeling at centromere (GO:0031055)3.69387750
25CENP-A containing nucleosome assembly (GO:0034080)3.68563201
26IMP biosynthetic process (GO:0006188)3.67611772
27regulation of helicase activity (GO:0051095)3.59860326
28regulation of antigen processing and presentation (GO:0002577)3.58540359
29positive regulation of antigen processing and presentation (GO:0002579)3.57031184
30neutrophil activation involved in immune response (GO:0002283)3.56100437
31attachment of spindle microtubules to kinetochore (GO:0008608)3.51995401
32mitotic sister chromatid cohesion (GO:0007064)3.51937173
33antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.50588979
34antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.50588979
35formation of translation preinitiation complex (GO:0001731)3.50329872
36metaphase plate congression (GO:0051310)3.49901943
37folic acid-containing compound biosynthetic process (GO:0009396)3.48622034
38myeloid dendritic cell activation (GO:0001773)3.48433493
39DNA replication initiation (GO:0006270)3.47651910
40regulation of RIG-I signaling pathway (GO:0039535)3.47051199
41somatic hypermutation of immunoglobulin genes (GO:0016446)3.41997478
42somatic diversification of immune receptors via somatic mutation (GO:0002566)3.41997478
43telomere maintenance via recombination (GO:0000722)3.40321142
44negative regulation of chromosome segregation (GO:0051985)3.40123582
45immunoglobulin mediated immune response (GO:0016064)3.38935509
46negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.34634425
47negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.34634425
48negative regulation of mitotic sister chromatid segregation (GO:0033048)3.34634425
49negative regulation of mitotic sister chromatid separation (GO:2000816)3.34634425
50negative regulation of sister chromatid segregation (GO:0033046)3.34634425
51establishment of viral latency (GO:0019043)3.34274955
52pore complex assembly (GO:0046931)3.34069414
53negative thymic T cell selection (GO:0045060)3.33739795
54dendritic cell differentiation (GO:0097028)3.33590007
55mitotic nuclear envelope disassembly (GO:0007077)3.33137090
56purine nucleobase biosynthetic process (GO:0009113)3.32408391
57mitotic recombination (GO:0006312)3.30134565
58neutrophil activation (GO:0042119)3.29948683
59negative regulation of DNA-dependent DNA replication (GO:2000104)3.28471350
60cell adhesion mediated by integrin (GO:0033627)3.25418032
61IMP metabolic process (GO:0046040)3.24939609
62regulation of mitotic metaphase/anaphase transition (GO:0030071)3.24132674
63regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.24132674
64regulation of B cell receptor signaling pathway (GO:0050855)3.23699386
65positive regulation of interleukin-12 production (GO:0032735)3.22048643
66somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.18892530
67somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.18892530
68isotype switching (GO:0045190)3.18892530
69regulation of integrin activation (GO:0033623)3.18786975
70cellular protein complex localization (GO:0034629)3.18770994
71regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.18647233
72mitotic G2/M transition checkpoint (GO:0044818)3.16975056
73B cell mediated immunity (GO:0019724)3.16108440
74protein complex localization (GO:0031503)3.14951788
75positive regulation of chromosome segregation (GO:0051984)3.14447359
76negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.13274661
77DNA ligation (GO:0006266)3.13043709
78negative T cell selection (GO:0043383)3.12249591
79mitotic chromosome condensation (GO:0007076)3.11703609
80granulocyte activation (GO:0036230)3.11065495
81spindle checkpoint (GO:0031577)3.09856202
82regulation of mitotic sister chromatid separation (GO:0010965)3.09845838
83regulation of mitotic sister chromatid segregation (GO:0033047)3.09845838
84regulation of sister chromatid segregation (GO:0033045)3.09845838
85histone exchange (GO:0043486)3.09518880
86cellular response to growth hormone stimulus (GO:0071378)3.08747057
87mitotic spindle checkpoint (GO:0071174)3.08270201
88establishment of chromosome localization (GO:0051303)3.06462135
89nuclear envelope disassembly (GO:0051081)3.05108810
90membrane disassembly (GO:0030397)3.05108810
91regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.04832590
92nucleobase biosynthetic process (GO:0046112)3.04530176
93proteasome assembly (GO:0043248)3.04238736
94telomere maintenance via telomere lengthening (GO:0010833)3.01624253
95regulation of chromosome segregation (GO:0051983)3.01212461
96somatic recombination of immunoglobulin gene segments (GO:0016447)3.00560920
97mitotic spindle assembly checkpoint (GO:0007094)2.98946747
98DNA catabolic process, exonucleolytic (GO:0000738)2.97923968
99spindle assembly checkpoint (GO:0071173)2.96369891
100Arp2/3 complex-mediated actin nucleation (GO:0034314)2.96092701
101non-recombinational repair (GO:0000726)2.95677916
102double-strand break repair via nonhomologous end joining (GO:0006303)2.95677916
103antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.95609923
104negative regulation of ligase activity (GO:0051352)2.95264990
105negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.95264990
106regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.95173531
107regulation of mitotic spindle checkpoint (GO:1903504)2.95173531
108negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.91841938
109negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.91718128
110DNA topological change (GO:0006265)2.90851932
111regulation of necroptotic process (GO:0060544)2.90822301
112positive regulation of interleukin-2 production (GO:0032743)2.90567232
113anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.89029709
114DNA replication-independent nucleosome organization (GO:0034724)2.88172897
115DNA replication-independent nucleosome assembly (GO:0006336)2.88172897
116negative regulation of mRNA processing (GO:0050686)2.87822478
117somatic cell DNA recombination (GO:0016444)2.87338019
118somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.87338019
119hepatocyte apoptotic process (GO:0097284)2.86196844
120ribosome biogenesis (GO:0042254)2.85687086
121T-helper cell differentiation (GO:0042093)2.85554674
122CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.85554674
123DNA replication-dependent nucleosome assembly (GO:0006335)2.84013402
124DNA replication-dependent nucleosome organization (GO:0034723)2.84013402
125regulation of interleukin-12 production (GO:0032655)2.83984861
126ribosomal large subunit biogenesis (GO:0042273)2.83073129
127DNA duplex unwinding (GO:0032508)2.81418223
128G1/S transition of mitotic cell cycle (GO:0000082)2.81190291
129cell cycle G1/S phase transition (GO:0044843)2.81190291
130interferon-gamma-mediated signaling pathway (GO:0060333)2.81104554
131regulation of centriole replication (GO:0046599)2.80177179
132DNA double-strand break processing (GO:0000729)2.80146302
133T cell differentiation involved in immune response (GO:0002292)2.79979111
134alpha-beta T cell differentiation involved in immune response (GO:0002293)2.79979111
135alpha-beta T cell activation involved in immune response (GO:0002287)2.79979111
136mature B cell differentiation (GO:0002335)2.79107581
137regulation of nuclear cell cycle DNA replication (GO:0033262)2.78727754
138regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.78698408
139positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.77336184
140somatic diversification of immunoglobulins (GO:0016445)2.76920181
141nucleotide-excision repair, DNA gap filling (GO:0006297)2.76893445
142heterochromatin organization (GO:0070828)2.76824789
143DNA geometric change (GO:0032392)2.76191276
144positive regulation of cell size (GO:0045793)2.76138988
145leukocyte mediated cytotoxicity (GO:0001909)2.73997529
146dendritic cell migration (GO:0036336)2.73871468
147negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.72787329
148cytokine secretion (GO:0050663)2.71186644
149positive regulation of gamma-delta T cell activation (GO:0046645)2.69203905
150lymphocyte mediated immunity (GO:0002449)2.66788601
151regulation of B cell apoptotic process (GO:0002902)2.64280413
152germinal center formation (GO:0002467)2.59735545
153negative regulation of B cell apoptotic process (GO:0002903)2.57359365
154necroptotic process (GO:0070266)2.56989999
155activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.55407967
156positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.53322910
157mature B cell differentiation involved in immune response (GO:0002313)2.48935054
158negative regulation of cell killing (GO:0031342)2.47070965
159negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.47070965
160regulation of MHC class I biosynthetic process (GO:0045343)2.46715976
161T cell activation involved in immune response (GO:0002286)2.45330212
162negative regulation of necroptotic process (GO:0060546)2.44398108
163JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.43715837
164positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.42979356
165regulation of response to interferon-gamma (GO:0060330)2.42509839
166regulation of interleukin-1 beta secretion (GO:0050706)2.42452894
167positive thymic T cell selection (GO:0045059)2.41544994
168negative regulation of B cell proliferation (GO:0030889)2.41418979
169regulation of T-helper 1 cell differentiation (GO:0045625)2.40341294
170regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.40198046
171positive regulation of natural killer cell differentiation (GO:0032825)2.39207888
172negative regulation of granulocyte differentiation (GO:0030853)2.38956129
173T cell migration (GO:0072678)2.38833103
174regulation of T cell tolerance induction (GO:0002664)2.38478335
175regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.36550406
176thymic T cell selection (GO:0045061)2.33820697
177regulation of protein heterodimerization activity (GO:0043497)2.33430255
178nuclear pore complex assembly (GO:0051292)2.32342311
179response to peptidoglycan (GO:0032494)2.32272545
180ruffle organization (GO:0031529)2.30304956
181regulation of B cell differentiation (GO:0045577)2.30014643
182tolerance induction (GO:0002507)2.30000181
183nuclear pore organization (GO:0006999)2.29003937
184tyrosine phosphorylation of STAT protein (GO:0007260)2.28982715
185cellular response to interferon-gamma (GO:0071346)2.28747270
186* positive regulation of protein oligomerization (GO:0032461)2.27414537
187actin nucleation (GO:0045010)2.27159591
188positive regulation of monocyte chemotaxis (GO:0090026)2.26444259
189embryonic process involved in female pregnancy (GO:0060136)2.25729174
190positive regulation of p38MAPK cascade (GO:1900745)2.24745581
191regulation of cellular extravasation (GO:0002691)2.24667076
1923-UTR-mediated mRNA stabilization (GO:0070935)2.24604590
193T cell apoptotic process (GO:0070231)2.24443875
194positive regulation of protein import into nucleus, translocation (GO:0033160)2.24039728
195regulation of alpha-beta T cell proliferation (GO:0046640)2.23486006
196positive regulation of type 2 immune response (GO:0002830)2.22766766
197positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.22550306
198positive regulation of interferon-alpha production (GO:0032727)2.22017544

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human5.65396181
2E2F7_22180533_ChIP-Seq_HELA_Human4.74804635
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.25134883
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.98282359
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.94059246
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.68079373
7* TP63_17297297_ChIP-ChIP_HaCaT_Human3.61381304
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.59915280
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.86070529
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.80980414
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.79338396
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.78796024
13* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.78349191
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.72994864
15* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.72838516
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.68839951
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.66021580
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.65428829
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.60250552
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.53424300
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.41452727
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.40610680
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.39233822
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.30169010
25E2F1_21310950_ChIP-Seq_MCF-7_Human2.27674800
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.27342134
27VDR_23849224_ChIP-Seq_CD4+_Human2.25610276
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.23812426
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.22473493
30ETS1_20019798_ChIP-Seq_JURKAT_Human2.19847782
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.16213936
32FOXP3_21729870_ChIP-Seq_TREG_Human2.12177074
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.12028111
34DCP1A_22483619_ChIP-Seq_HELA_Human2.11148819
35KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.09052875
36AR_21909140_ChIP-Seq_LNCAP_Human2.02589347
37FOXM1_23109430_ChIP-Seq_U2OS_Human1.96594924
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.95475517
39* XRN2_22483619_ChIP-Seq_HELA_Human1.95162341
40* TTF2_22483619_ChIP-Seq_HELA_Human1.92796311
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90694688
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.89826238
43* MYB_26560356_Chip-Seq_TH2_Human1.88642156
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.87379766
45* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86257975
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.83502068
47MAF_26560356_Chip-Seq_TH1_Human1.81986765
48KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.80282821
49KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.80282821
50KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.80282821
51NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79196934
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78295205
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.77141896
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.77118551
55MYC_22102868_ChIP-Seq_BL_Human1.76619862
56SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.76426659
57* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.75794490
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.74423869
59BP1_19119308_ChIP-ChIP_Hs578T_Human1.71288589
60TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.70466028
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68967993
62* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.64316615
63HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63476496
64NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62487050
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62370118
66VDR_21846776_ChIP-Seq_THP-1_Human1.61521193
67SPI1_23547873_ChIP-Seq_NB4_Human1.61024871
68ELF1_17652178_ChIP-ChIP_JURKAT_Human1.58922083
69RUNX_20019798_ChIP-Seq_JUKART_Human1.58110699
70* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.57542578
71* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.57542578
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.54881075
73MYB_26560356_Chip-Seq_TH1_Human1.54551980
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54061405
75CLOCK_20551151_ChIP-Seq_293T_Human1.53616724
76STAT3_1855785_ChIP-Seq_MESCs_Mouse1.52386442
77* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.51749157
78GABP_19822575_ChIP-Seq_HepG2_Human1.51448730
79TCF7_22412390_ChIP-Seq_EML_Mouse1.51101524
80* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.48182811
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.47192230
82CIITA_25753668_ChIP-Seq_RAJI_Human1.46762757
83FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.45230522
84HIF1A_21447827_ChIP-Seq_MCF-7_Human1.45209946
85* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44785220
86ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43855975
87ELK3_25401928_ChIP-Seq_HUVEC_Human1.36694528
88RUNX1_22412390_ChIP-Seq_EML_Mouse1.34834674
89* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.34823034
90* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.34694515
91SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32006265
92ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31536525
93VDR_24763502_ChIP-Seq_THP-1_Human1.30795573
94SMAD_19615063_ChIP-ChIP_OVARY_Human1.28903010
95E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.28886611
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28779888
97ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.28737881
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28301355
99SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25659452
100MYC_18940864_ChIP-ChIP_HL60_Human1.23502685
101TFEB_21752829_ChIP-Seq_HELA_Human1.21932757
102PU_27001747_Chip-Seq_BMDM_Mouse1.21577197
103UTX_26944678_Chip-Seq_JUKART_Human1.19609439
104* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.19572780
105KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17639299
106KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15098896
107CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.15080881
108* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14430314
109SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.13954530
110KDM5A_27292631_Chip-Seq_BREAST_Human1.13671433
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13199327
112KDM2B_26808549_Chip-Seq_DND41_Human1.12846881
113PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12252966
114TRIM28_21343339_ChIP-Seq_HEK293_Human1.12132655
115NANOG_16153702_ChIP-ChIP_HESCs_Human1.11950348
116KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11509177
117* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.10934231
118* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.10717296
119FOXO3_23340844_ChIP-Seq_DLD1_Human1.10500716
120RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10036785
121SRF_21415370_ChIP-Seq_HL-1_Mouse1.10002764
122TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09683753
123RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07063687
124POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07006779
125TP63_19390658_ChIP-ChIP_HaCaT_Human1.06963925
126FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.05973155
127SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05351962
128CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04075074
129KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03629258
130PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03360489
131GATA3_27048872_Chip-Seq_THYMUS_Human1.03340236
132FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03111370
133MYC_19079543_ChIP-ChIP_MESCs_Mouse1.01128562
134PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00399829
135YY1_21170310_ChIP-Seq_MESCs_Mouse0.99990245
136POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99950740
137ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99134930
138GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98327591
139TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97981410
140NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97157523
141CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96765173
142VDR_24787735_ChIP-Seq_THP-1_Human0.96546849
143UBF1/2_26484160_Chip-Seq_HMECs_Human0.95991477
144STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95253060
145SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95147967
146NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94606536
147SALL1_21062744_ChIP-ChIP_HESCs_Human0.94219029
148MAF_26560356_Chip-Seq_TH2_Human0.94073376
149SOX2_16153702_ChIP-ChIP_HESCs_Human0.93274397
150ELK1_19687146_ChIP-ChIP_HELA_Human0.92948199
151SPI1_23127762_ChIP-Seq_K562_Human0.92641389
152ESR1_21235772_ChIP-Seq_MCF-7_Human0.92509759
153BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92216665
154EWS_26573619_Chip-Seq_HEK293_Human0.92040664
155CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91659604
156SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91283373
157* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90929688
158E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.90722832
159CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90543755
160MYC_18555785_ChIP-Seq_MESCs_Mouse0.88955220
161ZNF263_19887448_ChIP-Seq_K562_Human0.88941669
162CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.88501544
163BRD4_25478319_ChIP-Seq_HGPS_Human0.87045163
164EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.86944205
165* ATF3_27146783_Chip-Seq_COLON_Human0.86326054
166RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.85953544
167KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85904780
168* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85210883
169WT1_19549856_ChIP-ChIP_CCG9911_Human0.85106748

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010352_gastrointestinal_tract_polyps3.86231254
2MP0001835_abnormal_antigen_presentation3.72867348
3MP0008058_abnormal_DNA_repair3.66697330
4MP0002254_reproductive_system_inflammat3.47186675
5MP0002138_abnormal_hepatobiliary_system3.10691552
6MP0004510_myositis3.01275281
7MP0000685_abnormal_immune_system2.67481484
8MP0001853_heart_inflammation2.59379974
9MP0003303_peritoneal_inflammation2.45293616
10MP0008932_abnormal_embryonic_tissue2.45221046
11MP0003436_decreased_susceptibility_to2.44368372
12MP0001348_abnormal_lacrimal_gland2.37777246
13MP0002148_abnormal_hypersensitivity_rea2.34752425
14MP0002166_altered_tumor_susceptibility2.21377672
15MP0001800_abnormal_humoral_immune2.19218137
16MP0002452_abnormal_antigen_presenting2.16947761
17MP0001790_abnormal_immune_system2.15441933
18MP0005387_immune_system_phenotype2.15441933
19MP0002006_tumorigenesis2.14560809
20MP0005000_abnormal_immune_tolerance2.13578248
21MP0002877_abnormal_melanocyte_morpholog2.12829471
22MP0005671_abnormal_response_to2.08112276
23MP0009785_altered_susceptibility_to2.04565745
24MP0009697_abnormal_copulation2.02767666
25MP0003566_abnormal_cell_adhesion1.98437144
26MP0008057_abnormal_DNA_replication1.96694933
27MP0008877_abnormal_DNA_methylation1.95706471
28MP0002009_preneoplasia1.94687210
29MP0003786_premature_aging1.94427763
30MP0002419_abnormal_innate_immunity1.92410865
31MP0003941_abnormal_skin_development1.90040879
32MP0002723_abnormal_immune_serum1.89017369
33MP0010234_abnormal_vibrissa_follicle1.84751579
34MP0001873_stomach_inflammation1.83846087
35MP0004947_skin_inflammation1.83355135
36MP0001730_embryonic_growth_arrest1.83123314
37MP0005076_abnormal_cell_differentiation1.82763054
38MP0001819_abnormal_immune_cell1.80651999
39MP0002420_abnormal_adaptive_immunity1.78518883
40MP0002405_respiratory_system_inflammati1.73742463
41MP0003091_abnormal_cell_migration1.73197424
42MP0005025_abnormal_response_to1.73003747
43MP0003448_altered_tumor_morphology1.72197722
44MP0005310_abnormal_salivary_gland1.67568738
45MP0003453_abnormal_keratinocyte_physiol1.66807671
46MP0010307_abnormal_tumor_latency1.66642772
47MP0003806_abnormal_nucleotide_metabolis1.63846188
48MP0008007_abnormal_cellular_replicative1.57941601
49MP0010155_abnormal_intestine_physiology1.57496449
50* MP0000313_abnormal_cell_death1.55482815
51MP0003718_maternal_effect1.55450621
52MP0003705_abnormal_hypodermis_morpholog1.54833924
53MP0000569_abnormal_digit_pigmentation1.53969587
54MP0000858_altered_metastatic_potential1.53047368
55MP0003300_gastrointestinal_ulcer1.52992047
56MP0002398_abnormal_bone_marrow1.47995816
57MP0005623_abnormal_meninges_morphology1.42288195
58* MP0000716_abnormal_immune_system1.41511170
59MP0001672_abnormal_embryogenesis/_devel1.33315888
60MP0005380_embryogenesis_phenotype1.33315888
61MP0001697_abnormal_embryo_size1.32242560
62MP0002722_abnormal_immune_system1.23540554
63MP0009333_abnormal_splenocyte_physiolog1.21410833
64MP0005023_abnormal_wound_healing1.21338209
65MP0002080_prenatal_lethality1.21080381
66MP0001845_abnormal_inflammatory_respons1.18538268
67* MP0002429_abnormal_blood_cell1.17602926
68MP0002396_abnormal_hematopoietic_system1.17564779
69MP0004808_abnormal_hematopoietic_stem1.17419469
70MP0000689_abnormal_spleen_morphology1.14769909
71MP0003077_abnormal_cell_cycle1.14747276
72MP0003984_embryonic_growth_retardation1.14583517
73MP0001533_abnormal_skeleton_physiology1.14278219
74MP0003763_abnormal_thymus_physiology1.13288914
75MP0006082_CNS_inflammation1.11631415
76MP0006035_abnormal_mitochondrial_morpho1.10423248
77MP0002088_abnormal_embryonic_growth/wei1.10016755
78MP0000490_abnormal_crypts_of1.09217688
79MP0009672_abnormal_birth_weight1.07331682
80MP0000703_abnormal_thymus_morphology1.02449158
81MP0001545_abnormal_hematopoietic_system1.01725244
82MP0005397_hematopoietic_system_phenotyp1.01725244
83MP0002277_abnormal_respiratory_mucosa1.01707886
84MP0000350_abnormal_cell_proliferation1.01523668
85MP0000733_abnormal_muscle_development1.00163610
86MP0003890_abnormal_embryonic-extraembry0.99073908
87MP0001346_abnormal_lacrimal_gland0.98449562
88MP0002085_abnormal_embryonic_tissue0.98064292
89MP0001293_anophthalmia0.97553748
90MP0003045_fibrosis0.96234713
91MP0009278_abnormal_bone_marrow0.96070254
92MP0002086_abnormal_extraembryonic_tissu0.95774433
93MP0005464_abnormal_platelet_physiology0.95326069
94MP0003221_abnormal_cardiomyocyte_apopto0.94972246
95MP0002933_joint_inflammation0.94175148
96MP0004957_abnormal_blastocyst_morpholog0.92413452
97MP0004197_abnormal_fetal_growth/weight/0.92000615
98MP0000627_abnormal_mammary_gland0.91826244
99MP0002084_abnormal_developmental_patter0.91621543
100MP0001243_abnormal_dermal_layer0.87954318
101MP0009053_abnormal_anal_canal0.87887487
102MP0000358_abnormal_cell_content/0.85980127
103MP0001216_abnormal_epidermal_layer0.85774842
104MP0005058_abnormal_lysosome_morphology0.85596466
105MP0002998_abnormal_bone_remodeling0.83954979
106MP0005621_abnormal_cell_physiology0.83510755
107MP0003828_pulmonary_edema0.81593500
108MP0008438_abnormal_cutaneous_collagen0.81016980
109MP0000537_abnormal_urethra_morphology0.80972924
110MP0001188_hyperpigmentation0.80456843
111MP0005384_cellular_phenotype0.78173927
112MP0002019_abnormal_tumor_incidence0.77695762
113MP0010094_abnormal_chromosome_stability0.77266112
114MP0003693_abnormal_embryo_hatching0.77209389
115MP0002210_abnormal_sex_determination0.77184176
116MP0003111_abnormal_nucleus_morphology0.76441565
117MP0008469_abnormal_protein_level0.76192703
118MP0000767_abnormal_smooth_muscle0.74987271
119MP0005390_skeleton_phenotype0.74740144
120MP0002163_abnormal_gland_morphology0.72742514
121MP0001929_abnormal_gametogenesis0.72222247
122MP0001851_eye_inflammation0.72027525
123MP0001145_abnormal_male_reproductive0.70457569
124MP0006036_abnormal_mitochondrial_physio0.70347297
125MP0001881_abnormal_mammary_gland0.69461939
126MP0001191_abnormal_skin_condition0.69221170
127MP0003172_abnormal_lysosome_physiology0.68721007
128MP0003567_abnormal_fetal_cardiomyocyte0.67386350
129MP0001119_abnormal_female_reproductive0.65863291
130MP0001915_intracranial_hemorrhage0.65656429
131MP0003186_abnormal_redox_activity0.65631256
132MP0002060_abnormal_skin_morphology0.64569114
133MP0003866_abnormal_defecation0.63603749
134MP0004185_abnormal_adipocyte_glucose0.62786363
135MP0000343_altered_response_to0.62591529
136MP0000470_abnormal_stomach_morphology0.61826088
137MP0002136_abnormal_kidney_physiology0.61584233
138MP0001727_abnormal_embryo_implantation0.61147886
139MP0008873_increased_physiological_sensi0.60331055
140MP0000653_abnormal_sex_gland0.59206295

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.85372452
2Chromsome breakage (HP:0040012)4.54952086
3Recurrent abscess formation (HP:0002722)4.14592370
4Eczematoid dermatitis (HP:0000976)4.11034105
5Recurrent bacterial skin infections (HP:0005406)4.01759339
6Peritonitis (HP:0002586)3.75237631
7Recurrent fungal infections (HP:0002841)3.74994380
8Abnormality of chromosome stability (HP:0003220)3.71291070
9Hematochezia (HP:0002573)3.60669569
10Birth length less than 3rd percentile (HP:0003561)3.51586323
11Recurrent viral infections (HP:0004429)3.51492422
12B lymphocytopenia (HP:0010976)3.46207225
13Mediastinal lymphadenopathy (HP:0100721)3.34440408
14IgM deficiency (HP:0002850)3.32579110
15Abnormality of the preputium (HP:0100587)3.28941935
16Nephroblastoma (Wilms tumor) (HP:0002667)3.28136792
17IgA deficiency (HP:0002720)3.28004667
18Multiple enchondromatosis (HP:0005701)3.26352047
19Abnormality of B cell number (HP:0010975)3.24827570
20Meckel diverticulum (HP:0002245)3.19142825
21Progressive external ophthalmoplegia (HP:0000590)3.14052251
22IgG deficiency (HP:0004315)3.12015063
23Squamous cell carcinoma (HP:0002860)3.10028459
24Abnormality of the ileum (HP:0001549)3.07194298
25Elevated erythrocyte sedimentation rate (HP:0003565)3.05001872
26Myositis (HP:0100614)3.04068348
27Embryonal renal neoplasm (HP:0011794)3.02762409
28Carpal bone hypoplasia (HP:0001498)3.01068086
29Microvesicular hepatic steatosis (HP:0001414)3.00761800
30Reticulocytopenia (HP:0001896)2.95602379
31Aplasia/Hypoplasia of the uvula (HP:0010293)2.90676991
32Thrombocytosis (HP:0001894)2.87913790
33Rhabdomyosarcoma (HP:0002859)2.81630335
34Gastrointestinal infarctions (HP:0005244)2.80476354
35Orchitis (HP:0100796)2.78439554
36Duodenal stenosis (HP:0100867)2.76736333
37Small intestinal stenosis (HP:0012848)2.76736333
38Autoimmune hemolytic anemia (HP:0001890)2.76346825
39Myocardial infarction (HP:0001658)2.75882805
40Recurrent skin infections (HP:0001581)2.74764243
41Myelodysplasia (HP:0002863)2.74416451
42Recurrent cutaneous fungal infections (HP:0011370)2.69926610
43Chronic mucocutaneous candidiasis (HP:0002728)2.69926610
44Interstitial pulmonary disease (HP:0006530)2.69723882
45Osteolytic defects of the phalanges of the hand (HP:0009771)2.67475771
46Osteolytic defects of the hand bones (HP:0009699)2.67475771
47Aplastic anemia (HP:0001915)2.67188842
48Pulmonary infiltrates (HP:0002113)2.64953203
49Amaurosis fugax (HP:0100576)2.63838019
50Fatigue (HP:0012378)2.62666517
51Autoimmune thrombocytopenia (HP:0001973)2.61597228
52Arterial thrombosis (HP:0004420)2.61265105
53Leukocytosis (HP:0001974)2.60877237
54Abnormality of macrophages (HP:0004311)2.60352696
55Medulloblastoma (HP:0002885)2.60040951
56Retrobulbar optic neuritis (HP:0100654)2.59458604
57Optic neuritis (HP:0100653)2.59458604
58Colitis (HP:0002583)2.58305049
59Chronic otitis media (HP:0000389)2.57044064
60Lymphoma (HP:0002665)2.55066722
61Basal cell carcinoma (HP:0002671)2.53135208
62Eosinophilia (HP:0001880)2.52473139
63Acute lymphatic leukemia (HP:0006721)2.51265583
64Short middle phalanx of the 5th finger (HP:0004220)2.48084237
65Combined immunodeficiency (HP:0005387)2.47027287
66Periodontitis (HP:0000704)2.44415458
67Increased IgE level (HP:0003212)2.43564357
68Abnormal lung lobation (HP:0002101)2.43029768
69Abnormality of the peritoneum (HP:0002585)2.41685201
70Nasal polyposis (HP:0100582)2.39899293
71Inflammation of the large intestine (HP:0002037)2.39806050
72Volvulus (HP:0002580)2.35055014
73Selective tooth agenesis (HP:0001592)2.33548845
74Stomatitis (HP:0010280)2.30778030
75Pancytopenia (HP:0001876)2.29333036
76Reduced antithrombin III activity (HP:0001976)2.28879347
77Abnormal delayed hypersensitivity skin test (HP:0002963)2.27003931
78Progressive muscle weakness (HP:0003323)2.26226235
79Sloping forehead (HP:0000340)2.26111810
80Gingivitis (HP:0000230)2.25935120
81Abnormality of the duodenum (HP:0002246)2.24400591
82Granulocytopenia (HP:0001913)2.23677362
83Gastrointestinal inflammation (HP:0004386)2.23216597
84Persistence of primary teeth (HP:0006335)2.21724741
85Pustule (HP:0200039)2.21070081
86Sensory axonal neuropathy (HP:0003390)2.19932877
87Abnormality of the pons (HP:0007361)2.19668008
88Cleft eyelid (HP:0000625)2.19337397
89Thick nail (HP:0001805)2.18450147
90Clubbing of toes (HP:0100760)2.17243175
91Acute myeloid leukemia (HP:0004808)2.14495873
92Recurrent gram-negative bacterial infections (HP:0005420)2.14386919
93Atrophic scars (HP:0001075)2.14270781
94Cellulitis (HP:0100658)2.12168147
95Abnormality of T cell number (HP:0011839)2.12104428
96Abnormality of cells of the lymphoid lineage (HP:0012140)2.11018439
97Milia (HP:0001056)2.10334783
98Esophageal varix (HP:0002040)2.09713783
99Ectopic kidney (HP:0000086)2.08955140
100Vasculitis (HP:0002633)2.08758598
101Spondylolisthesis (HP:0003302)2.08591253
102Abnormal number of incisors (HP:0011064)2.08408806
103Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.08380407
104Macrocytic anemia (HP:0001972)2.07668012
105Gastrointestinal stroma tumor (HP:0100723)2.07389998
106Prostate neoplasm (HP:0100787)2.07051776
107Lymphopenia (HP:0001888)2.06515665
108Abnormality of the prostate (HP:0008775)2.05591720
109Oral leukoplakia (HP:0002745)2.04441130
110Abnormality of eosinophils (HP:0001879)2.04317141
111Spastic diplegia (HP:0001264)2.04034702
112Increased IgM level (HP:0003496)2.02657350
113Chest pain (HP:0100749)2.00057362
114Neoplasm of the colon (HP:0100273)1.99869766
115Cellular immunodeficiency (HP:0005374)1.99711492
116Cortical dysplasia (HP:0002539)1.99109026
117Horseshoe kidney (HP:0000085)1.98622571
118Hypoplasia of the pons (HP:0012110)1.98083645
119Premature rupture of membranes (HP:0001788)1.97535629
120Abnormality of the labia minora (HP:0012880)1.96752414
121Viral hepatitis (HP:0006562)1.96693319
122Obstructive lung disease (HP:0006536)1.96649790
123Chronic obstructive pulmonary disease (HP:0006510)1.96649790
124Skin ulcer (HP:0200042)1.96141020
125Anhidrosis (HP:0000970)1.96028687
126Cafe-au-lait spot (HP:0000957)1.95642845
127Increased density of long bones (HP:0006392)1.94944488
128Type I transferrin isoform profile (HP:0003642)1.93079217
129Agnosia (HP:0010524)1.91900276
130Abnormality of methionine metabolism (HP:0010901)1.91673227
131Increased nuchal translucency (HP:0010880)1.91442711
132Poikiloderma (HP:0001029)1.90591244
133Abnormality of the nasal mucosa (HP:0000433)1.90540238
134Increased hepatocellular lipid droplets (HP:0006565)1.89336503
135Breast carcinoma (HP:0003002)1.88467878
136Aplasia/Hypoplasia of the sacrum (HP:0008517)1.87711114
137T lymphocytopenia (HP:0005403)1.87342893
138Abnormality of T cells (HP:0002843)1.86917459
139Syringomyelia (HP:0003396)1.86909012
140Spinal cord lesions (HP:0100561)1.86909012
141Degeneration of anterior horn cells (HP:0002398)1.86138693
142Abnormality of the anterior horn cell (HP:0006802)1.86138693
143Cutaneous melanoma (HP:0012056)1.86052121
144Vertebral compression fractures (HP:0002953)1.86035784
145Thyroiditis (HP:0100646)1.84490952
146Agammaglobulinemia (HP:0004432)1.84211514
147Severe combined immunodeficiency (HP:0004430)1.83438401
148Absent frontal sinuses (HP:0002688)1.83400779
149Absent thumb (HP:0009777)1.81358656
150Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.81309432
151Triphalangeal thumb (HP:0001199)1.80754899
152Panhypogammaglobulinemia (HP:0003139)1.80277918
153Megaloblastic anemia (HP:0001889)1.79078057
154Hypergammaglobulinemia (HP:0010702)1.78773424
155Abnormality of the carotid arteries (HP:0005344)1.78223635
156Prominent nose (HP:0000448)1.77467545
157Abnormality of T cell physiology (HP:0011840)1.76276713
158Embryonal neoplasm (HP:0002898)1.76074182
159Recurrent bronchitis (HP:0002837)1.76011150
160Stenosis of the external auditory canal (HP:0000402)1.75889319
161Chronic diarrhea (HP:0002028)1.74990701
162Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.74763800
163Abnormal protein N-linked glycosylation (HP:0012347)1.74763800
164Abnormal protein glycosylation (HP:0012346)1.74763800
165Abnormal glycosylation (HP:0012345)1.74763800
166Abnormality of the nasal septum (HP:0000419)1.74754767
167Ependymoma (HP:0002888)1.74151406
168Absent radius (HP:0003974)1.73653570
169Vacuolated lymphocytes (HP:0001922)1.72775762
170Abnormality of the gastric mucosa (HP:0004295)1.71292418
171Porencephaly (HP:0002132)1.69693269
172Hydroxyprolinuria (HP:0003080)1.68772078
173Abnormality of proline metabolism (HP:0010907)1.68772078
174Frequent falls (HP:0002359)1.68554417
175Tetraparesis (HP:0002273)1.66716833
176Spinal muscular atrophy (HP:0007269)1.65973164
177Cervical subluxation (HP:0003308)1.62762205
178Gastrointestinal carcinoma (HP:0002672)1.62598602
179Malignant gastrointestinal tract tumors (HP:0006749)1.62598602
180Cheilitis (HP:0100825)1.61844056
181Fused cervical vertebrae (HP:0002949)1.61635980
182Dilatation of the ascending aorta (HP:0005111)1.61228483
183Meningitis (HP:0001287)1.59704056
184Acrocyanosis (HP:0001063)1.59525772
185Stomach cancer (HP:0012126)1.58893965
186Colon cancer (HP:0003003)1.58611908
187Hemoptysis (HP:0002105)1.58595736
188Trismus (HP:0000211)1.57855033

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.88244676
2BUB14.74599036
3IKBKB3.21427898
4TYK23.17990285
5EPHA23.14616011
6TTK2.94418117
7CHUK2.61356498
8SRPK12.53666262
9MAP3K132.53268606
10BRSK22.50649357
11MKNK12.50405441
12MKNK22.48164135
13TBK12.45973379
14NME22.39475950
15ZAK2.31831592
16JAK32.31131748
17CDK122.23615226
18TAF12.23355492
19VRK22.18561532
20STK102.17025271
21FLT32.06550794
22MAP4K12.00156055
23PLK31.94515886
24PLK41.93520773
25IRAK31.92819609
26IRAK41.88295180
27VRK11.86132709
28NEK11.82626881
29RPS6KA41.70946002
30PASK1.70126433
31JAK11.70018822
32EPHB11.64781338
33STK161.64214056
34IKBKE1.61879483
35CSF1R1.55365269
36PLK11.51683563
37RIPK41.51498275
38CHEK21.45394366
39NUAK11.45313400
40PIM21.44829920
41PIM11.44623937
42BLK1.42530308
43ERBB41.38067442
44PBK1.37343264
45TRIM281.36603696
46MST41.34539167
47LRRK21.32317575
48SMG11.31396215
49ATR1.30738174
50CSK1.30150918
51PAK41.26734864
52TESK11.25496933
53TSSK61.23277754
54RIPK11.23165330
55EPHA31.22660243
56KIT1.21618844
57TESK21.17067599
58TTN1.16417972
59MAP3K31.14970119
60BMX1.14245309
61BRSK11.12723671
62FGR1.11809317
63EIF2AK11.10863502
64PTK61.10539255
65STK241.09502740
66FGFR41.02392336
67AURKB1.01541960
68MAP3K101.00109656
69MAP2K30.99659468
70MAP3K80.99242936
71CHEK10.99102626
72NLK0.96187991
73CDK60.94405154
74ZAP700.93886458
75SCYL20.93218552
76NEK90.90943083
77MAP2K20.90538954
78ITK0.89132193
79CDK190.88110715
80RPS6KB20.87946117
81MAPKAPK20.87860353
82CDK40.82692273
83STK40.81865064
84GRK60.81324798
85ALK0.81313232
86TRPM70.80911123
87FGFR30.79655381
88MOS0.77985883
89EIF2AK20.77002394
90MELK0.73988589
91CDK70.72909357
92ATM0.72475804
93STK30.72022257
94SIK30.71356536
95TGFBR10.70510104
96TLK10.69948470
97TXK0.69762077
98PRKAA20.69510927
99PTK20.68760615
100LCK0.63899314
101NME10.63061140
102ACVR1B0.62169049
103CLK10.61007651
104JAK20.60970033
105CDK90.60266776
106BMPR20.59972734
107BRAF0.59144303
108IRAK10.58353395
109MATK0.58321793
110HCK0.58263470
111AURKA0.57949846
112TNIK0.56889724
113TEC0.56607236
114BTK0.56495212
115EEF2K0.55200245
116CDK30.52737827
117BRD40.51744351
118DYRK1B0.51658509
119IRAK20.51275803
120TAOK20.50713739
121RPS6KA50.50408193
122MAPKAPK30.50378742
123PKN20.49032993
124DYRK30.48668344
125KDR0.47047246
126PAK20.46478208
127DAPK10.46157136
128NEK20.45761416
129CDC70.45422046
130TGFBR20.44722364
131CDK20.44292428
132EIF2AK30.44013287
133BCR0.43767618
134ABL10.43627548
135CDK80.43000578
136EGFR0.42208375
137GSK3A0.41565745
138PDGFRB0.41425139
139ERBB30.40565297
140CSNK2A10.40101579
141PRKCI0.39972366
142CSNK2A20.38455777
143STK38L0.37897912
144WEE10.37814072
145MAP3K50.37481138
146RPS6KA10.37378893
147TAOK30.37041429
148PAK10.36877068
149SYK0.36655202
150MET0.35701087
151INSR0.35291311
152RET0.35183945
153CDK10.35100450
154PKN10.33343900
155LATS20.32594624
156LATS10.31625236
157CCNB10.31367183
158PRPF4B0.30260803
159BMPR1B0.28408427

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.91417422
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.90282279
3Antigen processing and presentation_Homo sapiens_hsa046122.56858758
4Homologous recombination_Homo sapiens_hsa034402.48046432
5Base excision repair_Homo sapiens_hsa034102.33703513
6Graft-versus-host disease_Homo sapiens_hsa053322.29913178
7RNA polymerase_Homo sapiens_hsa030202.18491392
8TNF signaling pathway_Homo sapiens_hsa046682.08905535
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.05967038
10Ribosome_Homo sapiens_hsa030102.04661627
11Osteoclast differentiation_Homo sapiens_hsa043802.04000409
12Toxoplasmosis_Homo sapiens_hsa051452.03080190
13Nucleotide excision repair_Homo sapiens_hsa034202.02438522
14Asthma_Homo sapiens_hsa053101.94643956
15RNA degradation_Homo sapiens_hsa030181.94518117
16Allograft rejection_Homo sapiens_hsa053301.87623192
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.86619643
18* Apoptosis_Homo sapiens_hsa042101.86595544
19Fanconi anemia pathway_Homo sapiens_hsa034601.83820870
20Small cell lung cancer_Homo sapiens_hsa052221.82278876
21Shigellosis_Homo sapiens_hsa051311.80320117
22Measles_Homo sapiens_hsa051621.79512022
23Legionellosis_Homo sapiens_hsa051341.75741594
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.72092296
25Pyrimidine metabolism_Homo sapiens_hsa002401.69010068
26* p53 signaling pathway_Homo sapiens_hsa041151.67718747
27Basal transcription factors_Homo sapiens_hsa030221.62808841
28B cell receptor signaling pathway_Homo sapiens_hsa046621.59764277
29Herpes simplex infection_Homo sapiens_hsa051681.58729972
30Epstein-Barr virus infection_Homo sapiens_hsa051691.47081876
31Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.46725829
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.46520200
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46461234
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46056499
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.43695480
36mRNA surveillance pathway_Homo sapiens_hsa030151.42330038
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.40662225
38Influenza A_Homo sapiens_hsa051641.40147791
39Tuberculosis_Homo sapiens_hsa051521.40018837
40Chronic myeloid leukemia_Homo sapiens_hsa052201.36344037
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.36000282
42Viral myocarditis_Homo sapiens_hsa054161.34397047
43Selenocompound metabolism_Homo sapiens_hsa004501.34113483
44Protein export_Homo sapiens_hsa030601.33637804
45Pertussis_Homo sapiens_hsa051331.32104613
46T cell receptor signaling pathway_Homo sapiens_hsa046601.27063203
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.27011350
48Salmonella infection_Homo sapiens_hsa051321.26779979
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.26608634
50Jak-STAT signaling pathway_Homo sapiens_hsa046301.23362559
51MicroRNAs in cancer_Homo sapiens_hsa052061.22620473
52Chemokine signaling pathway_Homo sapiens_hsa040621.22313316
53* Viral carcinogenesis_Homo sapiens_hsa052031.21765012
54Primary immunodeficiency_Homo sapiens_hsa053401.21426851
55Malaria_Homo sapiens_hsa051441.20499068
56Hepatitis B_Homo sapiens_hsa051611.18130590
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18086170
58Acute myeloid leukemia_Homo sapiens_hsa052211.17233752
59Transcriptional misregulation in cancer_Homo sapiens_hsa052021.11036556
60HTLV-I infection_Homo sapiens_hsa051661.08731723
61Purine metabolism_Homo sapiens_hsa002301.05463809
62Adherens junction_Homo sapiens_hsa045201.04762900
63Hematopoietic cell lineage_Homo sapiens_hsa046401.03837886
64Type I diabetes mellitus_Homo sapiens_hsa049401.03699903
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02339080
66Pancreatic cancer_Homo sapiens_hsa052121.02323766
67Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.01988441
68Proteoglycans in cancer_Homo sapiens_hsa052050.95215699
69Amoebiasis_Homo sapiens_hsa051460.90134607
70One carbon pool by folate_Homo sapiens_hsa006700.85342151
71Hepatitis C_Homo sapiens_hsa051600.84966362
72HIF-1 signaling pathway_Homo sapiens_hsa040660.83813519
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83684762
74African trypanosomiasis_Homo sapiens_hsa051430.83523523
75Autoimmune thyroid disease_Homo sapiens_hsa053200.82205681
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.81961855
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81847863
78Rheumatoid arthritis_Homo sapiens_hsa053230.81561568
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80471839
80Colorectal cancer_Homo sapiens_hsa052100.78333162
81Focal adhesion_Homo sapiens_hsa045100.77793512
82Biosynthesis of amino acids_Homo sapiens_hsa012300.77027340
83TGF-beta signaling pathway_Homo sapiens_hsa043500.76276585
84Cell cycle_Homo sapiens_hsa041100.75469591
85Pathways in cancer_Homo sapiens_hsa052000.72282329
86Bladder cancer_Homo sapiens_hsa052190.68935698
87DNA replication_Homo sapiens_hsa030300.68653622
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67972719
89VEGF signaling pathway_Homo sapiens_hsa043700.67318984
90Other glycan degradation_Homo sapiens_hsa005110.65149979
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64948797
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64672055
93Lysosome_Homo sapiens_hsa041420.64212760
94Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63398223
95Spliceosome_Homo sapiens_hsa030400.60841494
96Prolactin signaling pathway_Homo sapiens_hsa049170.60791968
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59961830
98Oocyte meiosis_Homo sapiens_hsa041140.59580760
99Non-homologous end-joining_Homo sapiens_hsa034500.59343094
100Mismatch repair_Homo sapiens_hsa034300.58442541
101Prostate cancer_Homo sapiens_hsa052150.58310865
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58227041
103Renin-angiotensin system_Homo sapiens_hsa046140.57519234
104MAPK signaling pathway_Homo sapiens_hsa040100.57285741
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.56925355
106Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55778715
107Vitamin B6 metabolism_Homo sapiens_hsa007500.55693797
108Hippo signaling pathway_Homo sapiens_hsa043900.55352909
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54526432
110Platelet activation_Homo sapiens_hsa046110.53725228
111FoxO signaling pathway_Homo sapiens_hsa040680.53364658
112RNA transport_Homo sapiens_hsa030130.52805816
113ECM-receptor interaction_Homo sapiens_hsa045120.52162062
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51989849
115Proteasome_Homo sapiens_hsa030500.50596461
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49526398
117Staphylococcus aureus infection_Homo sapiens_hsa051500.49225709
118Parkinsons disease_Homo sapiens_hsa050120.46777462
119Renal cell carcinoma_Homo sapiens_hsa052110.45344507
120Phagosome_Homo sapiens_hsa041450.45159334
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42427602
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42187825
123Huntingtons disease_Homo sapiens_hsa050160.41707181
124Alcoholism_Homo sapiens_hsa050340.41673619
125Systemic lupus erythematosus_Homo sapiens_hsa053220.41051743
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.38735480
127Notch signaling pathway_Homo sapiens_hsa043300.38260293
128Folate biosynthesis_Homo sapiens_hsa007900.38005227
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37893426
130Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.37892750
131Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37557664
1322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.35762231
133Carbon metabolism_Homo sapiens_hsa012000.33744901
134Pyruvate metabolism_Homo sapiens_hsa006200.32464453
135Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30599776
136Thyroid cancer_Homo sapiens_hsa052160.25750699
137Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23527777
138Pentose phosphate pathway_Homo sapiens_hsa000300.21991245
139Glutathione metabolism_Homo sapiens_hsa004800.21732262
140Oxidative phosphorylation_Homo sapiens_hsa001900.21506480
141Propanoate metabolism_Homo sapiens_hsa006400.21265630
142N-Glycan biosynthesis_Homo sapiens_hsa005100.16878403

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