PMCH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include melanin-concentrating hormone (MCH), neuropeptide-glutamic acid-isoleucine (NEI), and neuropeptide-glycine-glutamic acid (NGE). Melanin-concentrating hormone is a 19-amino acid neuropeptide that stimulates hunger and may additionally regulate energy homeostasis, reproductive function, and sleep. Pseudogenes of this gene have been identified on chromosome 5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lung lobe morphogenesis (GO:0060463)9.96794870
2regulation of transmission of nerve impulse (GO:0051969)9.80791401
3negative regulation of DNA recombination (GO:0045910)9.41457499
4prostate gland growth (GO:0060736)8.99927350
5regulation of double-strand break repair via homologous recombination (GO:0010569)8.70481702
6sequestering of actin monomers (GO:0042989)7.73917060
7cranial suture morphogenesis (GO:0060363)7.53673757
8positive regulation of neurological system process (GO:0031646)7.15179980
9positive regulation of catecholamine secretion (GO:0033605)7.12355409
10adult feeding behavior (GO:0008343)6.65026388
11exocrine pancreas development (GO:0031017)6.42051647
12branching involved in prostate gland morphogenesis (GO:0060442)6.15551961
13viral transcription (GO:0019083)6.13924760
14negative regulation of response to food (GO:0032096)6.04168431
15negative regulation of appetite (GO:0032099)6.04168431
16craniofacial suture morphogenesis (GO:0097094)6.04022918
17lung vasculature development (GO:0060426)5.82587599
18translational termination (GO:0006415)5.81623039
19ribosomal small subunit assembly (GO:0000028)5.39474696
20negative regulation of bone resorption (GO:0045779)5.38478578
21synaptic vesicle maturation (GO:0016188)5.26332636
22regulation of calcineurin-NFAT signaling cascade (GO:0070884)5.09115564
23synaptic vesicle exocytosis (GO:0016079)5.02388525
24SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.97947167
25regulation of double-strand break repair (GO:2000779)4.92730647
26cotranslational protein targeting to membrane (GO:0006613)4.92687997
27photoreceptor cell differentiation (GO:0046530)4.90576032
28eye photoreceptor cell differentiation (GO:0001754)4.90576032
29protein targeting to ER (GO:0045047)4.87360525
30gland morphogenesis (GO:0022612)4.75287413
31oxygen transport (GO:0015671)4.75008301
32translational elongation (GO:0006414)4.71990019
33regulation of phospholipase A2 activity (GO:0032429)4.71396816
34establishment of protein localization to endoplasmic reticulum (GO:0072599)4.68024028
35gamma-aminobutyric acid signaling pathway (GO:0007214)4.66678936
36viral life cycle (GO:0019058)4.57055203
37regulation of short-term neuronal synaptic plasticity (GO:0048172)4.51509241
38protein localization to endoplasmic reticulum (GO:0070972)4.49970103
39lateral sprouting from an epithelium (GO:0060601)4.49084096
40positive regulation of protein import into nucleus, translocation (GO:0033160)4.48353207
41somite development (GO:0061053)4.46202140
42negative regulation of androgen receptor signaling pathway (GO:0060766)4.44906071
43regulation of response to food (GO:0032095)4.44330793
44mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.41596556
45negative regulation of bone remodeling (GO:0046851)4.37328615
46cellular protein complex disassembly (GO:0043624)4.33964179
47otic vesicle formation (GO:0030916)4.30101701
48regulation of synaptic vesicle exocytosis (GO:2000300)4.28857116
49regulation of smooth muscle cell apoptotic process (GO:0034391)4.24781936
50glutamate secretion (GO:0014047)4.22393639
51nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.19934785
52positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)4.18757480
53positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.06935079
54neurotransmitter catabolic process (GO:0042135)3.99725594
55negative regulation of tissue remodeling (GO:0034104)3.98522155
56proline transport (GO:0015824)3.94946815
57lung secretory cell differentiation (GO:0061140)3.93072237
58regulation of appetite (GO:0032098)3.88976002
59postsynaptic membrane organization (GO:0001941)3.86540683
60DNA replication initiation (GO:0006270)3.85834265
61limb bud formation (GO:0060174)3.84888418
62positive regulation of cardiac muscle hypertrophy (GO:0010613)3.84519017
63positive regulation of muscle hypertrophy (GO:0014742)3.84519017
64translational initiation (GO:0006413)3.81129805
65neurotransmitter secretion (GO:0007269)3.76322610
66neuron projection extension involved in neuron projection guidance (GO:1902284)3.74896834
67axon extension involved in axon guidance (GO:0048846)3.74896834
68positive regulation of amine transport (GO:0051954)3.74289573
69mammary gland development (GO:0030879)3.74091616
70mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.72974590
71regulation of dopamine metabolic process (GO:0042053)3.70959733
72regulation of catecholamine metabolic process (GO:0042069)3.70959733
73tachykinin receptor signaling pathway (GO:0007217)3.67902833
74protein localization to synapse (GO:0035418)3.66236110
75regulation of synaptic vesicle transport (GO:1902803)3.65824662
76protein complex disassembly (GO:0043241)3.61643571
77respiratory electron transport chain (GO:0022904)3.59788720
78cGMP biosynthetic process (GO:0006182)3.58532830
79ribosomal small subunit biogenesis (GO:0042274)3.58111899
80pyrimidine dimer repair (GO:0006290)3.57697334
81succinate metabolic process (GO:0006105)3.55424875
82centriole replication (GO:0007099)3.53081412
83negative regulation of response to DNA damage stimulus (GO:2001021)3.52798686
84electron transport chain (GO:0022900)3.52736166
85neuromuscular process controlling posture (GO:0050884)3.52634588
86energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.52358570
87ATP hydrolysis coupled proton transport (GO:0015991)3.52358570
88neuron cell-cell adhesion (GO:0007158)3.51559117
89macromolecular complex disassembly (GO:0032984)3.51237019
90insulin-like growth factor receptor signaling pathway (GO:0048009)3.51219859
91regulation of phospholipid biosynthetic process (GO:0071071)3.46700082
92response to laminar fluid shear stress (GO:0034616)3.44976543
93regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.42895518
94positive regulation of glycogen biosynthetic process (GO:0045725)3.42863150
95heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)3.39643072
96protein targeting to membrane (GO:0006612)3.37891836
97arachidonic acid secretion (GO:0050482)3.36541830
98icosanoid secretion (GO:0032309)3.36541830
99calcium-mediated signaling using intracellular calcium source (GO:0035584)3.35157897
100lung alveolus development (GO:0048286)3.32486358
101cerebellar Purkinje cell layer development (GO:0021680)3.31820208
102regulation of neurotransmitter levels (GO:0001505)3.30279863
103locomotory exploration behavior (GO:0035641)3.29807123
104neurotransmitter transport (GO:0006836)3.28692652
105positive regulation of glycolytic process (GO:0045821)3.25947008
106regulation of uterine smooth muscle contraction (GO:0070472)3.23248550
107maturation of SSU-rRNA (GO:0030490)3.21874908
108ATP synthesis coupled proton transport (GO:0015986)3.20559520
109energy coupled proton transport, down electrochemical gradient (GO:0015985)3.20559520
110neural tube formation (GO:0001841)3.20488487
111behavioral response to nicotine (GO:0035095)3.19180865
112negative regulation of response to nutrient levels (GO:0032108)3.16554999
113negative regulation of response to extracellular stimulus (GO:0032105)3.16554999
114positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.16157654
115regulation of vesicle fusion (GO:0031338)3.15781426
116organ growth (GO:0035265)3.15651799
117vesicle transport along microtubule (GO:0047496)3.12278829
118activation of protein kinase A activity (GO:0034199)3.11742063
119lens fiber cell development (GO:0070307)3.11123860
120positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.08114959
121inner ear receptor stereocilium organization (GO:0060122)3.07875946
122oxaloacetate metabolic process (GO:0006107)3.07688951
123layer formation in cerebral cortex (GO:0021819)3.07037767
124serotonin receptor signaling pathway (GO:0007210)3.06339151
125prostate gland epithelium morphogenesis (GO:0060740)3.06025558
126base-excision repair, AP site formation (GO:0006285)3.04937824
127epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.04367675
128transferrin transport (GO:0033572)3.03742555
129cilium or flagellum-dependent cell motility (GO:0001539)3.01581060
130regulation of catecholamine secretion (GO:0050433)2.99401499
131chaperone-mediated protein transport (GO:0072321)2.98986418
132establishment of protein localization to mitochondrial membrane (GO:0090151)2.96271394
133negative regulation of neurotransmitter secretion (GO:0046929)2.95276673
134regulation of protein kinase A signaling (GO:0010738)2.94588168
135neuron recognition (GO:0008038)2.94383414
136inositol phosphate-mediated signaling (GO:0048016)2.92851924
137trivalent inorganic cation transport (GO:0072512)2.88367719
138ferric iron transport (GO:0015682)2.88367719
139positive regulation of glycogen metabolic process (GO:0070875)2.87973239
140negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.87672846
141negative regulation of translation, ncRNA-mediated (GO:0040033)2.87672846
142regulation of translation, ncRNA-mediated (GO:0045974)2.87672846
143peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.86501570
144branch elongation of an epithelium (GO:0060602)2.86484164
145regulation of oxidative phosphorylation (GO:0002082)2.86326600
146omega-hydroxylase P450 pathway (GO:0097267)2.84982060
147mesenchymal cell proliferation (GO:0010463)2.84747286
148retinal ganglion cell axon guidance (GO:0031290)2.82937386
149negative regulation of osteoclast differentiation (GO:0045671)2.82802522
150exploration behavior (GO:0035640)2.81687940
151viral protein processing (GO:0019082)2.81538954
152NADH metabolic process (GO:0006734)2.78254415
153positive regulation of SMAD protein import into nucleus (GO:0060391)2.77857085
154presynaptic membrane assembly (GO:0097105)2.74182980
155tricarboxylic acid cycle (GO:0006099)2.73500257
156ionotropic glutamate receptor signaling pathway (GO:0035235)2.72655240
157gas transport (GO:0015669)2.71204387
158glutamate receptor signaling pathway (GO:0007215)2.70568006
159regulation of respiratory system process (GO:0044065)2.69271329
160respiratory system process (GO:0003016)2.69116506
161regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.67313281
162regulation of protein import into nucleus, translocation (GO:0033158)2.67093915
163hyperosmotic salinity response (GO:0042538)2.66998068
164positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.66099799
165organelle transport along microtubule (GO:0072384)2.65528544
166response to histamine (GO:0034776)2.62564483
167coenzyme catabolic process (GO:0009109)2.62385557
168negative regulation of microtubule polymerization (GO:0031115)2.62293837
169regulation of long-term neuronal synaptic plasticity (GO:0048169)2.61392498
170inner mitochondrial membrane organization (GO:0007007)2.58494594
171neuronal action potential propagation (GO:0019227)2.57330923
172regulation of feeding behavior (GO:0060259)2.57023567
173regulation of glutamate receptor signaling pathway (GO:1900449)2.55539448
174signal release (GO:0023061)2.55396548
175regulation of neuronal synaptic plasticity (GO:0048168)2.55077873
176synaptic vesicle docking involved in exocytosis (GO:0016081)2.54743129
177neurotransmitter uptake (GO:0001504)2.52352595
178vocalization behavior (GO:0071625)2.51988638
179positive regulation of blood pressure (GO:0045777)2.50392996
180positive regulation of uterine smooth muscle contraction (GO:0070474)2.49597531
181G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.48322498
182regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.47492458
183mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.46706239
184fatty acid elongation (GO:0030497)2.46342594
185cellular response to glucagon stimulus (GO:0071377)2.45455620
186aldehyde catabolic process (GO:0046185)2.45248185
187negative regulation of DNA repair (GO:0045738)19.2219729
188prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:00605211.4647404

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human4.62957930
2EZH2_22144423_ChIP-Seq_EOC_Human4.48573636
3TP63_19390658_ChIP-ChIP_HaCaT_Human3.84948848
4GBX2_23144817_ChIP-Seq_PC3_Human3.52792235
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.31143524
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.23680517
7RBPJ_22232070_ChIP-Seq_NCS_Mouse3.20286998
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.16670553
9CBX2_27304074_Chip-Seq_ESCs_Mouse3.01346187
10REST_21632747_ChIP-Seq_MESCs_Mouse2.89379934
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.88157859
12ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.76106235
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.69759324
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.68757756
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.67914158
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.66530673
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.63329422
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60510317
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58291807
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.57016644
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.51202958
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.46097323
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.44864546
24RNF2_18974828_ChIP-Seq_MESCs_Mouse2.30982436
25EZH2_18974828_ChIP-Seq_MESCs_Mouse2.30982436
26JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29058830
27RARB_27405468_Chip-Seq_BRAIN_Mouse2.23772562
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14915725
29EWS_26573619_Chip-Seq_HEK293_Human2.13606128
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.04293116
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.00203432
32TAF15_26573619_Chip-Seq_HEK293_Human1.97380463
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.95745272
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.93254323
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.89518707
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.88877078
37NR3C1_23031785_ChIP-Seq_PC12_Mouse1.85208006
38CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.83639526
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81677648
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.78850413
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77321971
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.73902119
43P300_19829295_ChIP-Seq_ESCs_Human1.73284011
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.73115041
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72721936
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.72198596
47GABP_17652178_ChIP-ChIP_JURKAT_Human1.71457212
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70494639
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.70494639
50KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.67432645
51DROSHA_22980978_ChIP-Seq_HELA_Human1.66324111
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.66101756
53AR_21572438_ChIP-Seq_LNCaP_Human1.65623971
54RNF2_27304074_Chip-Seq_NSC_Mouse1.63028742
55CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.61033915
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61022152
57EST1_17652178_ChIP-ChIP_JURKAT_Human1.60851137
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.59349001
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56520951
60HIF1A_21447827_ChIP-Seq_MCF-7_Human1.54826138
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.51399361
62EED_16625203_ChIP-ChIP_MESCs_Mouse1.49916271
63ZNF274_21170338_ChIP-Seq_K562_Hela1.49259920
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.48646334
65BCAT_22108803_ChIP-Seq_LS180_Human1.48322273
66TP53_20018659_ChIP-ChIP_R1E_Mouse1.47835060
67SOX2_21211035_ChIP-Seq_LN229_Gbm1.47543638
68* SMAD4_21799915_ChIP-Seq_A2780_Human1.47452599
69DNAJC2_21179169_ChIP-ChIP_NT2_Human1.45188007
70ERG_21242973_ChIP-ChIP_JURKAT_Human1.44992062
71PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.44961323
72GATA1_26923725_Chip-Seq_HPCs_Mouse1.41384277
73BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40367085
74MYC_18940864_ChIP-ChIP_HL60_Human1.39128674
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39036788
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38306777
77JUN_21703547_ChIP-Seq_K562_Human1.38122762
78ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38083821
79ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.35622694
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34948514
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33698606
82ZNF263_19887448_ChIP-Seq_K562_Human1.29043556
83ELK1_22589737_ChIP-Seq_MCF10A_Human1.28981158
84CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.25266949
85FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.23453435
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18938462
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18070794
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.15529484
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15046446
90FUS_26573619_Chip-Seq_HEK293_Human1.14224945
91ELK1_19687146_ChIP-ChIP_HELA_Human1.14130138
92* SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.13598148
93ER_23166858_ChIP-Seq_MCF-7_Human1.13198041
94SOX2_16153702_ChIP-ChIP_HESCs_Human1.12349661
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11148716
96EOMES_21245162_ChIP-Seq_HESCs_Human1.11023514
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11006900
98GATA3_21878914_ChIP-Seq_MCF-7_Human1.09278699
99E2F1_17053090_ChIP-ChIP_MCF-7_Human1.08219462
100* AR_25329375_ChIP-Seq_VCAP_Human1.07900638
101* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06622272
102RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05941438
103LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05390192
104GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04804934
105ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03788096
106TRIM28_21343339_ChIP-Seq_HEK293_Human1.03431688
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02053320
108CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01365125
109THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00878798
110ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00650153
111SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00459324
112IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99972286
113CBP_20019798_ChIP-Seq_JUKART_Human0.99972286
114EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98538815
115PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97838314
116SMAD3_21741376_ChIP-Seq_ESCs_Human0.97743274
117EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96790726
118WT1_19549856_ChIP-ChIP_CCG9911_Human0.96522207
119TBX3_20139965_ChIP-Seq_MESCs_Mouse0.96288819
120TBX3_20139965_ChIP-Seq_ESCs_Mouse0.95903405
121RING1B_27294783_Chip-Seq_NPCs_Mouse0.95068997
122KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94054000
123HTT_18923047_ChIP-ChIP_STHdh_Human0.93985974
124TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93588479
125RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93155862
126SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92541340
127BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91826734
128SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91535427
129PRDM14_20953172_ChIP-Seq_ESCs_Human0.91458132
130TP53_18474530_ChIP-ChIP_U2OS_Human0.90827883
131* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89558318
132SOX2_19829295_ChIP-Seq_ESCs_Human0.89515514
133NANOG_19829295_ChIP-Seq_ESCs_Human0.89515514
134TCF4_22108803_ChIP-Seq_LS180_Human0.89145960
135P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88643643
136EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87574279
137WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.87554460
138KLF5_20875108_ChIP-Seq_MESCs_Mouse0.87378638
139TP53_16413492_ChIP-PET_HCT116_Human0.86369585
140MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86364861
141SOX9_26525672_Chip-Seq_HEART_Mouse0.86067951
142YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85950787
143STAT6_21828071_ChIP-Seq_BEAS2B_Human0.85549102
144GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.85456796
145RUNX2_22187159_ChIP-Seq_PCA_Human0.85360660
146NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83568915
147NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83568915
148TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82883482

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology6.84565249
2MP0003880_abnormal_central_pattern4.84389869
3MP0004859_abnormal_synaptic_plasticity4.80473888
4MP0003122_maternal_imprinting4.29207496
5MP0000566_synostosis4.13288600
6MP0001346_abnormal_lacrimal_gland4.12740466
7MP0000537_abnormal_urethra_morphology3.67053908
8MP0003635_abnormal_synaptic_transmissio3.46026871
9MP0003938_abnormal_ear_development3.36925123
10MP0004270_analgesia3.35458966
11MP0000372_irregular_coat_pigmentation3.34579968
12MP0008995_early_reproductive_senescence3.16452259
13MP0002064_seizures3.11791093
14MP0009745_abnormal_behavioral_response2.95811524
15MP0003787_abnormal_imprinting2.93802182
16MP0002295_abnormal_pulmonary_circulatio2.93453886
17MP0006276_abnormal_autonomic_nervous2.89196596
18MP0005248_abnormal_Harderian_gland2.75794825
19MP0009046_muscle_twitch2.73302476
20MP0008961_abnormal_basal_metabolism2.66207485
21MP0002063_abnormal_learning/memory/cond2.64240578
22MP0000579_abnormal_nail_morphology2.54449401
23MP0003329_amyloid_beta_deposits2.51725347
24MP0000751_myopathy2.46250892
25MP0002282_abnormal_trachea_morphology2.39114482
26MP0001529_abnormal_vocalization2.35881966
27MP0002272_abnormal_nervous_system2.29259722
28MP0001968_abnormal_touch/_nociception2.27560071
29MP0005408_hypopigmentation2.23892005
30MP0005423_abnormal_somatic_nervous2.19707068
31MP0004133_heterotaxia2.19397570
32MP0001440_abnormal_grooming_behavior2.19281467
33MP0002572_abnormal_emotion/affect_behav2.19188807
34MP0002734_abnormal_mechanical_nocicepti2.15393217
35MP0003638_abnormal_response/metabolism_2.13087306
36MP0002837_dystrophic_cardiac_calcinosis2.10604426
37MP0004142_abnormal_muscle_tone2.05181123
38MP0006292_abnormal_olfactory_placode1.91682289
39MP0002736_abnormal_nociception_after1.90392085
40MP0001501_abnormal_sleep_pattern1.84507344
41MP0000604_amyloidosis1.81796994
42MP0001542_abnormal_bone_strength1.78924842
43MP0002067_abnormal_sensory_capabilities1.78906414
44MP0005187_abnormal_penis_morphology1.77218455
45MP0005394_taste/olfaction_phenotype1.75042792
46MP0005499_abnormal_olfactory_system1.75042792
47MP0003121_genomic_imprinting1.74380623
48MP0002233_abnormal_nose_morphology1.73848199
49MP0002638_abnormal_pupillary_reflex1.71077773
50MP0002733_abnormal_thermal_nociception1.67877215
51MP0001970_abnormal_pain_threshold1.67504507
52MP0004043_abnormal_pH_regulation1.64948426
53MP0005646_abnormal_pituitary_gland1.64653935
54MP0005171_absent_coat_pigmentation1.64624257
55MP0000462_abnormal_digestive_system1.63466984
56MP0002332_abnormal_exercise_endurance1.59930084
57MP0000534_abnormal_ureter_morphology1.57609965
58MP0008877_abnormal_DNA_methylation1.53954227
59MP0003690_abnormal_glial_cell1.52896486
60MP0004924_abnormal_behavior1.49839772
61MP0005386_behavior/neurological_phenoty1.49839772
62MP0002909_abnormal_adrenal_gland1.49645103
63MP0001177_atelectasis1.49413851
64MP0004858_abnormal_nervous_system1.47858063
65MP0008872_abnormal_physiological_respon1.45800915
66MP0008875_abnormal_xenobiotic_pharmacok1.42145550
67MP0001286_abnormal_eye_development1.41640907
68MP0002697_abnormal_eye_size1.40977769
69MP0000747_muscle_weakness1.40845826
70MP0000778_abnormal_nervous_system1.39485534
71MP0003633_abnormal_nervous_system1.39429550
72MP0001188_hyperpigmentation1.36068653
73MP0000383_abnormal_hair_follicle1.35230182
74MP0002184_abnormal_innervation1.33168760
75MP0005623_abnormal_meninges_morphology1.32260643
76MP0002108_abnormal_muscle_morphology1.31087907
77MP0003315_abnormal_perineum_morphology1.27960760
78MP0005448_abnormal_energy_balance1.27867355
79MP0006035_abnormal_mitochondrial_morpho1.25645229
80MP0002066_abnormal_motor_capabilities/c1.24959577
81MP0001486_abnormal_startle_reflex1.24727024
82MP0005535_abnormal_body_temperature1.23645178
83MP0002234_abnormal_pharynx_morphology1.23533095
84MP0009379_abnormal_foot_pigmentation1.23025386
85MP0001905_abnormal_dopamine_level1.22547715
86MP0002139_abnormal_hepatobiliary_system1.22414974
87MP0003123_paternal_imprinting1.21405548
88MP0003631_nervous_system_phenotype1.19274654
89MP0009780_abnormal_chondrocyte_physiolo1.18254521
90MP0003283_abnormal_digestive_organ1.17448435
91MP0003942_abnormal_urinary_system1.16169023
92MP0005084_abnormal_gallbladder_morpholo1.16070401
93MP0002557_abnormal_social/conspecific_i1.15751367
94MP0002822_catalepsy1.12195118
95MP0000955_abnormal_spinal_cord1.11864605
96MP0002102_abnormal_ear_morphology1.11346911
97MP0000647_abnormal_sebaceous_gland1.09901744
98MP0005360_urolithiasis1.08271992
99MP0003075_altered_response_to1.08190948
100MP0003755_abnormal_palate_morphology1.07588470
101MP0008569_lethality_at_weaning1.07400476
102MP0002735_abnormal_chemical_nociception1.06228233
103MP0002277_abnormal_respiratory_mucosa1.05871120
104MP0002249_abnormal_larynx_morphology1.05855980
105MP0005058_abnormal_lysosome_morphology1.05527904
106MP0002876_abnormal_thyroid_physiology1.05303572
107MP0009250_abnormal_appendicular_skeleto1.04455283
108MP0000026_abnormal_inner_ear1.03974475
109MP0004036_abnormal_muscle_relaxation1.02486519
110MP0005167_abnormal_blood-brain_barrier1.01929258
111MP0000631_abnormal_neuroendocrine_gland1.01901849
112MP0003634_abnormal_glial_cell1.01360676
113MP0010329_abnormal_lipoprotein_level1.00189009
114MP0004811_abnormal_neuron_physiology0.99370341
115MP0002229_neurodegeneration0.97714114
116MP0003119_abnormal_digestive_system0.97682040
117MP0002882_abnormal_neuron_morphology0.96171693
118MP0004084_abnormal_cardiac_muscle0.95934601
119MP0005266_abnormal_metabolism0.95623874
120MP0004885_abnormal_endolymph0.95558287
121MP0005379_endocrine/exocrine_gland_phen0.94280945
122MP0000920_abnormal_myelination0.93748626
123MP0008789_abnormal_olfactory_epithelium0.93207770
124MP0003632_abnormal_nervous_system0.92939488
125MP0002938_white_spotting0.92068215
126MP0000762_abnormal_tongue_morphology0.92036519
127MP0005197_abnormal_uvea_morphology0.91918154
128MP0001879_abnormal_lymphatic_vessel0.90771173
129MP0008874_decreased_physiological_sensi0.90756866
130MP0009703_decreased_birth_body0.89077962
131* MP0002069_abnormal_eating/drinking_beha0.88611158
132MP0000013_abnormal_adipose_tissue0.88332783
133MP0005332_abnormal_amino_acid0.85747269
134MP0004145_abnormal_muscle_electrophysio0.84827296
135* MP0005452_abnormal_adipose_tissue0.84600689
136MP0001984_abnormal_olfaction0.83884132
137MP0006036_abnormal_mitochondrial_physio0.82898373
138MP0003115_abnormal_respiratory_system0.81563006
139MP0001502_abnormal_circadian_rhythm0.81058865
140MP0002078_abnormal_glucose_homeostasis0.80336269
141MP0001293_anophthalmia0.79629010
142MP0005551_abnormal_eye_electrophysiolog0.78716350
143MP0005085_abnormal_gallbladder_physiolo0.78583528
144MP0004883_abnormal_blood_vessel0.77036395
145MP0002090_abnormal_vision0.76826589
146MP0004233_abnormal_muscle_weight0.74816487
147MP0002152_abnormal_brain_morphology0.74184024
148MP0003786_premature_aging0.72302776
149MP0004085_abnormal_heartbeat0.71412672
150MP0003879_abnormal_hair_cell0.67951453
151MP0000230_abnormal_systemic_arterial0.67935402
152MP0001943_abnormal_respiration0.67671888
153MP0005645_abnormal_hypothalamus_physiol0.67460361
154MP0001299_abnormal_eye_distance/0.66639141
155MP0000003_abnormal_adipose_tissue0.66414675
156MP0003136_yellow_coat_color0.66176294
157MP0003045_fibrosis0.65464840
158MP0005376_homeostasis/metabolism_phenot0.65417414
159MP0003937_abnormal_limbs/digits/tail_de0.65324672
160MP0003959_abnormal_lean_body0.65296147
161MP0004484_altered_response_of0.63080769
162MP0000163_abnormal_cartilage_morphology0.61290897
163MP0001324_abnormal_eye_pigmentation0.58808299
164MP0006072_abnormal_retinal_apoptosis0.57636773
165MP0005503_abnormal_tendon_morphology0.56374370
166MP0002081_perinatal_lethality0.54549417
167MP0001963_abnormal_hearing_physiology0.54111994
168MP0002133_abnormal_respiratory_system0.53696698
169MP0005388_respiratory_system_phenotype0.53696698
170MP0003385_abnormal_body_wall0.52466924
171MP0001727_abnormal_embryo_implantation0.52361227
172MP0005195_abnormal_posterior_eye0.51742109
173MP0001666_abnormal_nutrient_absorption0.51120768

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.04049290
2Atonic seizures (HP:0010819)5.07889048
3Chronic otitis media (HP:0000389)4.97117601
4Oligomenorrhea (HP:0000876)4.85423665
5Focal motor seizures (HP:0011153)4.77726830
6Visual hallucinations (HP:0002367)4.53239315
7Stomach cancer (HP:0012126)4.48305571
8Esophageal atresia (HP:0002032)4.43279785
9Abnormal hair whorl (HP:0010721)4.40816145
10Acute necrotizing encephalopathy (HP:0006965)4.36588282
11Pheochromocytoma (HP:0002666)4.35979105
12Abnormal number of erythroid precursors (HP:0012131)4.31677009
13Abnormal mitochondria in muscle tissue (HP:0008316)4.14909122
14Partial duplication of the phalanx of hand (HP:0009999)4.12097063
15Coronal craniosynostosis (HP:0004440)4.11844260
16Abnormality of cells of the erythroid lineage (HP:0012130)4.11132432
17Turricephaly (HP:0000262)4.05179512
18Abnormality of the phalanges of the 2nd finger (HP:0009541)4.04923866
19Absence seizures (HP:0002121)4.02127404
20Abnormal ciliary motility (HP:0012262)4.01593524
21Absent/shortened dynein arms (HP:0200106)3.97776418
22Dynein arm defect of respiratory motile cilia (HP:0012255)3.97776418
23Failure to thrive in infancy (HP:0001531)3.97028384
24Abnormality of the labia minora (HP:0012880)3.96960120
25Focal seizures (HP:0007359)3.96287076
26Polyphagia (HP:0002591)3.92805147
27Neuroendocrine neoplasm (HP:0100634)3.92471039
28Partial duplication of thumb phalanx (HP:0009944)3.88803860
29Buphthalmos (HP:0000557)3.85736883
30Progressive macrocephaly (HP:0004481)3.75469369
31Acute encephalopathy (HP:0006846)3.75230603
32Stenosis of the external auditory canal (HP:0000402)3.74711896
33Abnormality of the parietal bone (HP:0002696)3.72691164
34Abnormal respiratory epithelium morphology (HP:0012253)3.64524356
35Abnormal respiratory motile cilium morphology (HP:0005938)3.64524356
36Abnormal gallbladder physiology (HP:0012438)3.63333887
37Cholecystitis (HP:0001082)3.63333887
38Generalized tonic-clonic seizures (HP:0002069)3.61345286
39Poor suck (HP:0002033)3.57095891
40Broad metatarsal (HP:0001783)3.51925305
41Anxiety (HP:0000739)3.50701638
42Abnormal respiratory motile cilium physiology (HP:0012261)3.46378736
43Mitochondrial inheritance (HP:0001427)3.45038140
44Abnormality of the middle phalanges of the toes (HP:0010183)3.39382428
45Short clavicles (HP:0000894)3.38874531
46Epileptic encephalopathy (HP:0200134)3.37999379
47Hepatocellular necrosis (HP:0001404)3.23635118
48Abnormal eating behavior (HP:0100738)3.22429375
49Aplasia involving bones of the upper limbs (HP:0009823)3.21200692
50Aplasia of the phalanges of the hand (HP:0009802)3.21200692
51Aplasia involving bones of the extremities (HP:0009825)3.21200692
52Thyroid-stimulating hormone excess (HP:0002925)3.14706474
53Dialeptic seizures (HP:0011146)3.14527043
54Supranuclear gaze palsy (HP:0000605)3.10171096
55Aqueductal stenosis (HP:0002410)3.07776171
56Right ventricular cardiomyopathy (HP:0011663)3.05784641
57Cerebral hemorrhage (HP:0001342)3.01910850
58Aplasia/Hypoplasia of the clavicles (HP:0006710)3.01859763
59Cerebral inclusion bodies (HP:0100314)2.98769143
60Dysdiadochokinesis (HP:0002075)2.98582151
61Abnormality of pain sensation (HP:0010832)2.97861383
62Impaired pain sensation (HP:0007328)2.97861383
63Cerebral edema (HP:0002181)2.96796107
64Neurofibrillary tangles (HP:0002185)2.95503916
65Nasolacrimal duct obstruction (HP:0000579)2.94857611
66Leukodystrophy (HP:0002415)2.89586833
67Progressive cerebellar ataxia (HP:0002073)2.86939091
68Decreased lacrimation (HP:0000633)2.86286001
69Abnormality of the antihelix (HP:0009738)2.83347182
70Congenital glaucoma (HP:0001087)2.81221128
71Decreased muscle mass (HP:0003199)2.74414017
72Synostosis involving the elbow (HP:0003938)2.71726014
73Humeroradial synostosis (HP:0003041)2.71726014
74Psychosis (HP:0000709)2.70093138
75Chronic sinusitis (HP:0011109)2.67204888
76Thickened helices (HP:0000391)2.66548893
77Megalencephaly (HP:0001355)2.65925725
78Increased CSF lactate (HP:0002490)2.65678315
79Hypoventilation (HP:0002791)2.65660720
80Macrocytic anemia (HP:0001972)2.62935774
81Premature skin wrinkling (HP:0100678)2.62202879
82Generalized myoclonic seizures (HP:0002123)2.60274631
83Narrow nasal bridge (HP:0000446)2.57957038
84Split foot (HP:0001839)2.57908447
85Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.54073791
86Short 4th metacarpal (HP:0010044)2.54073791
87Ulnar bowing (HP:0003031)2.53048274
88Gastrointestinal atresia (HP:0002589)2.52493020
89Bronchomalacia (HP:0002780)2.51855584
90Conjunctival hamartoma (HP:0100780)2.51778347
91Broad distal phalanx of finger (HP:0009836)2.50685323
92Optic disc pallor (HP:0000543)2.49488526
93Hepatic necrosis (HP:0002605)2.49303740
94Concave nail (HP:0001598)2.48839528
95Febrile seizures (HP:0002373)2.46969280
96Neoplasm of the peripheral nervous system (HP:0100007)2.45793753
97Delayed CNS myelination (HP:0002188)2.45580916
98Respiratory distress (HP:0002098)2.44402284
99Progressive inability to walk (HP:0002505)2.42490197
100Status epilepticus (HP:0002133)2.42227171
101Reticulocytopenia (HP:0001896)2.42022040
102Cutaneous finger syndactyly (HP:0010554)2.41646030
103Dysmetria (HP:0001310)2.41075845
104Sleep apnea (HP:0010535)2.40781186
105Rhinitis (HP:0012384)2.38884767
106Lipid accumulation in hepatocytes (HP:0006561)2.38503178
107Generalized hypotonia (HP:0001290)2.36249281
108Depression (HP:0000716)2.35986356
109Abnormality of the 2nd finger (HP:0004100)2.35731841
110Resting tremor (HP:0002322)2.33743685
111Delusions (HP:0000746)2.31375968
112Action tremor (HP:0002345)2.30236842
113Oral leukoplakia (HP:0002745)2.27591212
114EEG with generalized epileptiform discharges (HP:0011198)2.27315299
115Ketoacidosis (HP:0001993)2.25716047
116Abnormality of the nasolacrimal system (HP:0000614)2.23962613
117Bifid uvula (HP:0000193)2.23884649
118Epileptiform EEG discharges (HP:0011182)2.21138062
119Hypsarrhythmia (HP:0002521)2.20767615
120Myotonia (HP:0002486)2.19569685
121Trigonocephaly (HP:0000243)2.19534116
122Sensorimotor neuropathy (HP:0007141)2.18278960
123Abnormality of the lacrimal duct (HP:0011481)2.18119219
124Respiratory failure (HP:0002878)2.17084623
125Hypoplasia of the maxilla (HP:0000327)2.17076189
126Sparse scalp hair (HP:0002209)2.16357594
127Long nose (HP:0003189)2.15652072
128Gout (HP:0001997)2.14797442
129Shallow orbits (HP:0000586)2.12110861
130Poikiloderma (HP:0001029)2.11341897
131Esotropia (HP:0000565)2.10156587
132Esophageal neoplasm (HP:0100751)2.10019202
133Neoplasm of head and neck (HP:0012288)2.10019202
134Hypoplastic labia majora (HP:0000059)2.09412348
135Coxa valga (HP:0002673)2.09211243
136Truncal ataxia (HP:0002078)2.08319637
137Agitation (HP:0000713)2.07796698
138Duplication of thumb phalanx (HP:0009942)2.07791285
139Brushfield spots (HP:0001088)2.07291054
140Severe global developmental delay (HP:0011344)2.07204408
141Aplasia/Hypoplasia of the hallux (HP:0008362)2.07184824
142Enlarged kidneys (HP:0000105)2.06946884
143Sensory axonal neuropathy (HP:0003390)2.06798234
144Craniofacial dystonia (HP:0012179)2.06030496
145Alacrima (HP:0000522)2.04882403
146Focal dystonia (HP:0004373)2.04682410
147Hemiplegia (HP:0002301)2.03798896
148Wide anterior fontanel (HP:0000260)2.00928229
149Cutaneous syndactyly (HP:0012725)2.00556471
150Abnormality of incisor morphology (HP:0011063)1.99395143
151Labial hypoplasia (HP:0000066)1.99196003
152Emotional lability (HP:0000712)1.98721769
153Torticollis (HP:0000473)1.96891787
154X-linked dominant inheritance (HP:0001423)1.96160423
155Hyperventilation (HP:0002883)1.96037056
156Axonal loss (HP:0003447)1.94852881
157Scanning speech (HP:0002168)1.93209290
158Palpitations (HP:0001962)1.92409537
159Abnormality of the labia majora (HP:0012881)1.91327155
160Anteriorly placed anus (HP:0001545)1.91180928
161Absent septum pellucidum (HP:0001331)1.91126243
162Hypoplastic ischia (HP:0003175)1.87218093
163Nasal polyposis (HP:0100582)1.86844478
164Papilledema (HP:0001085)1.86430719
165Pulmonary artery stenosis (HP:0004415)1.84411766
166Increased corneal curvature (HP:0100692)1.83447641
167Keratoconus (HP:0000563)1.83447641
168Cholelithiasis (HP:0001081)1.83399787
169Ankle clonus (HP:0011448)1.82412740
170Postural instability (HP:0002172)1.82410217
171Exercise intolerance (HP:0003546)1.81167143
172Abnormality of the pubic bones (HP:0003172)1.79877230
173Hyperlipoproteinemia (HP:0010980)1.79854470
174Anterior segment dysgenesis (HP:0007700)1.79568970
175Abnormality of the 4th metacarpal (HP:0010012)1.79031307
176Abnormality of the corticospinal tract (HP:0002492)1.78676032
177Neonatal onset (HP:0003623)1.78587632
178Underdeveloped supraorbital ridges (HP:0009891)1.78279526
179Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.78171662
180Decreased central vision (HP:0007663)1.77802332
181Symphalangism affecting the phalanges of the hand (HP:0009773)1.77340938
182Intellectual disability, moderate (HP:0002342)1.76692621
183Hypoplasia of the iris (HP:0007676)1.76280749
184Overriding aorta (HP:0002623)1.75948157
185Mutism (HP:0002300)1.73810095
186Hypogonadotrophic hypogonadism (HP:0000044)1.73195328
187Lactic acidosis (HP:0003128)1.73113532
188Hypoplastic female external genitalia (HP:0012815)1.73035821
189Hemiparesis (HP:0001269)1.72592784
190Urinary urgency (HP:0000012)1.72577573
191Rapidly progressive (HP:0003678)1.72500890
192Exercise-induced myalgia (HP:0003738)1.71961868
193Horizontal nystagmus (HP:0000666)1.71844176
194Abnormal gallbladder morphology (HP:0012437)1.71788193
195Abnormality of the vocal cords (HP:0008777)1.70093516
196Bradykinesia (HP:0002067)1.69499571

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR26.89357606
2MAP3K125.58202288
3MAP3K43.90204816
4NTRK33.18152157
5MAPK153.17974404
6STK243.16691878
7MAP2K43.13381630
8MAP3K92.82445491
9MAP2K72.75024517
10RIPK42.72377144
11BMPR1B2.67275063
12VRK22.64067801
13PASK2.56530610
14MAP3K62.55073625
15ERBB32.44661537
16MINK12.38507933
17GRK52.31561521
18CASK2.31419139
19NME12.13368818
20FES2.07181795
21GRK71.88033896
22PNCK1.84426472
23PLK21.82478848
24MARK11.79277953
25UHMK11.76756784
26NTRK21.75702548
27EPHA41.73382428
28RIPK11.71649459
29ALK1.66509999
30SGK21.64752266
31CDK191.62654313
32ARAF1.61139515
33NEK21.58376454
34AKT31.58301500
35SIK21.55614999
36LMTK21.43335569
37FGFR11.42644048
38BRD41.42255208
39DYRK31.37216621
40RPS6KA41.31471957
41BUB11.30120922
42STK31.27757639
43CDK51.26720273
44KSR21.26636459
45NTRK11.25312445
46BCR1.23243270
47MAP3K111.17724386
48CAMK1G1.13560947
49TNIK1.12834123
50PAK61.12365167
51ADRBK11.09194218
52STK38L1.09162960
53PAK31.08240731
54OXSR11.07324289
55LIMK11.06566018
56CDK141.06367844
57PRKCG1.03707434
58MAPK71.03689234
59BLK0.99080456
60CSNK1G30.98910872
61DAPK20.98312091
62CSNK1G20.97911920
63CAMKK20.95689712
64TNK20.94580389
65FER0.94398892
66DAPK10.93251793
67PHKG10.92699671
68PHKG20.92699671
69GRK60.92128162
70CDK180.92100724
71CAMKK10.90593134
72CDK150.89579606
73CAMK2A0.88572918
74VRK10.85474532
75TAOK30.84841848
76WNK30.81409473
77STK390.81315818
78MYLK0.80491839
79INSRR0.80351194
80SGK30.78957481
81BCKDK0.78492248
82PINK10.77228419
83CDK11A0.76791714
84TGFBR10.76718697
85MAPK130.75909769
86CSNK1A1L0.73082648
87PRKCH0.71523683
88LATS20.70643165
89EPHA30.68632870
90KSR10.67817505
91PDK10.67463012
92TSSK60.67356764
93BMPR20.67136473
94CAMK2B0.66068731
95ROCK20.66059500
96CAMK2D0.65855417
97TLK10.61111265
98RET0.59819983
99MAP3K130.59537422
100MAP3K20.59500155
101MAPK40.59493412
102BRSK20.59355404
103CSK0.58735618
104ADRBK20.57947310
105SGK10.57884245
106PRKACB0.57071323
107PKN20.57057395
108PRKG20.55916088
109DYRK1A0.55687398
110PDPK10.54971708
111MAP3K50.54597086
112BRSK10.54502137
113DYRK20.53014103
114TYRO30.52789178
115MAP3K10.52489217
116MAP2K30.52400237
117NEK10.51285087
118CAMK2G0.50051631
119PIK3CA0.49826864
120PRKCZ0.49285394
121RPS6KB20.49262004
122LATS10.47728789
123WNK40.47444174
124OBSCN0.47065167
125FGR0.45560497
126PTK2B0.45534755
127DDR20.45360147
128FLT30.45248992
129PRKG10.44930532
130RPS6KA60.44923415
131MARK30.44758266
132CSNK1G10.44438169
133SIK10.41840564
134PRKCE0.41676924
135RPS6KL10.41425534
136RPS6KC10.41425534
137FYN0.41199783
138DAPK30.40435123
139PRKD30.39763700
140MST40.38710281
141MAP4K20.37872077
142NUAK10.37204278
143SGK4940.36962742
144SGK2230.36962742
145IKBKE0.36455121
146CAMK10.36339068
147CDC42BPA0.35868787
148RPS6KA30.35070223
149ABL20.33958952
150ROCK10.33719900
151PRKCB0.32428357
152PRKACA0.32020546
153TTN0.31727230
154PRKCA0.31475879
155RPS6KA50.31167547
156MUSK0.30212234
157MATK0.29921564
158PAK20.28556084
159MAP2K20.27684974
160AKT10.25916097
161EPHB10.25025352
162EPHB20.24950995
163STK110.23407561
164ZAP700.20214941
165CSNK2A10.19933604
166PKN10.19523641
167HIPK20.18887612
168PDGFRB0.18787345
169MAPK30.18622184
170SIK30.18437599
171RPS6KA10.18188369

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.55702711
2Nicotine addiction_Homo sapiens_hsa050333.78323153
3Oxidative phosphorylation_Homo sapiens_hsa001903.65117581
4Synaptic vesicle cycle_Homo sapiens_hsa047213.44156543
5Parkinsons disease_Homo sapiens_hsa050122.97586318
6GABAergic synapse_Homo sapiens_hsa047272.75253270
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.65614892
8Collecting duct acid secretion_Homo sapiens_hsa049662.57823968
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.49819259
10Alzheimers disease_Homo sapiens_hsa050102.44911996
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.42022691
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.32846954
13Ovarian steroidogenesis_Homo sapiens_hsa049132.31390492
14Morphine addiction_Homo sapiens_hsa050322.18388751
15Vibrio cholerae infection_Homo sapiens_hsa051102.15122131
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.98601409
17Sulfur relay system_Homo sapiens_hsa041221.97815110
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.97103407
19Huntingtons disease_Homo sapiens_hsa050161.91261900
20Olfactory transduction_Homo sapiens_hsa047401.90480316
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.90266342
22Folate biosynthesis_Homo sapiens_hsa007901.77965299
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.70136467
24Long-term potentiation_Homo sapiens_hsa047201.69636584
25Circadian entrainment_Homo sapiens_hsa047131.68432760
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62014525
27Taste transduction_Homo sapiens_hsa047421.56741757
28Protein export_Homo sapiens_hsa030601.51927103
29Pyruvate metabolism_Homo sapiens_hsa006201.50773193
30Dopaminergic synapse_Homo sapiens_hsa047281.48022858
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43407484
32Cardiac muscle contraction_Homo sapiens_hsa042601.43157497
33Glutamatergic synapse_Homo sapiens_hsa047241.42136192
34Renin secretion_Homo sapiens_hsa049241.33295519
35Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.29888740
36Amphetamine addiction_Homo sapiens_hsa050311.27871829
37Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.25658105
38Nitrogen metabolism_Homo sapiens_hsa009101.24922816
39Fatty acid elongation_Homo sapiens_hsa000621.23407623
40Long-term depression_Homo sapiens_hsa047301.23364721
41Mineral absorption_Homo sapiens_hsa049781.21964587
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21883075
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.21535793
44Salivary secretion_Homo sapiens_hsa049701.19745533
45Cholinergic synapse_Homo sapiens_hsa047251.14921764
46Insulin secretion_Homo sapiens_hsa049111.13705560
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13074589
48Chemical carcinogenesis_Homo sapiens_hsa052041.13068846
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.12467442
50Carbon metabolism_Homo sapiens_hsa012001.11926393
51TGF-beta signaling pathway_Homo sapiens_hsa043501.11416989
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11184799
53Gastric acid secretion_Homo sapiens_hsa049711.09359529
54Serotonergic synapse_Homo sapiens_hsa047261.09232308
55Arginine biosynthesis_Homo sapiens_hsa002201.08602316
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05391655
57SNARE interactions in vesicular transport_Homo sapiens_hsa041301.05142959
58Sulfur metabolism_Homo sapiens_hsa009201.04890034
59Butanoate metabolism_Homo sapiens_hsa006500.98334437
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.97031104
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94848683
62Proteasome_Homo sapiens_hsa030500.92675615
63Basal cell carcinoma_Homo sapiens_hsa052170.92434311
64Biosynthesis of amino acids_Homo sapiens_hsa012300.90688069
65Linoleic acid metabolism_Homo sapiens_hsa005910.90297944
66Tryptophan metabolism_Homo sapiens_hsa003800.88940535
67Gap junction_Homo sapiens_hsa045400.86157980
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84831935
69Cocaine addiction_Homo sapiens_hsa050300.84328834
70ABC transporters_Homo sapiens_hsa020100.84099067
71Propanoate metabolism_Homo sapiens_hsa006400.83042891
72Phagosome_Homo sapiens_hsa041450.81743632
73Pentose phosphate pathway_Homo sapiens_hsa000300.79565087
74Calcium signaling pathway_Homo sapiens_hsa040200.79460511
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79187729
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78531591
77Prion diseases_Homo sapiens_hsa050200.76628596
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74435037
79Basal transcription factors_Homo sapiens_hsa030220.74211993
80Rheumatoid arthritis_Homo sapiens_hsa053230.73097632
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72839157
82GnRH signaling pathway_Homo sapiens_hsa049120.70180605
83Fatty acid metabolism_Homo sapiens_hsa012120.69558417
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.68359711
85Type II diabetes mellitus_Homo sapiens_hsa049300.67255137
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66326734
87Phenylalanine metabolism_Homo sapiens_hsa003600.66253534
88Oxytocin signaling pathway_Homo sapiens_hsa049210.64713429
89Bile secretion_Homo sapiens_hsa049760.64277038
90Phototransduction_Homo sapiens_hsa047440.63183199
91Galactose metabolism_Homo sapiens_hsa000520.63182016
92Hedgehog signaling pathway_Homo sapiens_hsa043400.63007522
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.62806811
94Melanoma_Homo sapiens_hsa052180.61562147
95Malaria_Homo sapiens_hsa051440.61285431
96Fructose and mannose metabolism_Homo sapiens_hsa000510.58656174
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58279383
98Prostate cancer_Homo sapiens_hsa052150.57979117
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.57965537
100Estrogen signaling pathway_Homo sapiens_hsa049150.57106162
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55283645
102Vitamin digestion and absorption_Homo sapiens_hsa049770.55168526
103Colorectal cancer_Homo sapiens_hsa052100.54204930
104Thyroid hormone synthesis_Homo sapiens_hsa049180.54175806
105Type I diabetes mellitus_Homo sapiens_hsa049400.53490243
106Glucagon signaling pathway_Homo sapiens_hsa049220.53071585
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52786292
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52171822
109HIF-1 signaling pathway_Homo sapiens_hsa040660.50956763
110Protein digestion and absorption_Homo sapiens_hsa049740.50494758
111Oocyte meiosis_Homo sapiens_hsa041140.49547667
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49393871
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46818292
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45828738
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45729048
116Alcoholism_Homo sapiens_hsa050340.45529586
117Selenocompound metabolism_Homo sapiens_hsa004500.44342709
118Axon guidance_Homo sapiens_hsa043600.42369085
119p53 signaling pathway_Homo sapiens_hsa041150.41167641
120Pathways in cancer_Homo sapiens_hsa052000.39535042
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39342254
122Fatty acid degradation_Homo sapiens_hsa000710.39219515
123Peroxisome_Homo sapiens_hsa041460.39119283
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.38939127
125Complement and coagulation cascades_Homo sapiens_hsa046100.38774270
126Dilated cardiomyopathy_Homo sapiens_hsa054140.37820151
127Hippo signaling pathway_Homo sapiens_hsa043900.37188184
128cAMP signaling pathway_Homo sapiens_hsa040240.36876333
129mTOR signaling pathway_Homo sapiens_hsa041500.36694198
130mRNA surveillance pathway_Homo sapiens_hsa030150.35576610
131Melanogenesis_Homo sapiens_hsa049160.35336874
132Ras signaling pathway_Homo sapiens_hsa040140.35294072
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35013953
134RNA polymerase_Homo sapiens_hsa030200.34727262
135Vitamin B6 metabolism_Homo sapiens_hsa007500.34706312
136Arginine and proline metabolism_Homo sapiens_hsa003300.33256864
137Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32984193
138Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32795665
139cGMP-PKG signaling pathway_Homo sapiens_hsa040220.30283033
140Fatty acid biosynthesis_Homo sapiens_hsa000610.29548222
141Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28116226
142Wnt signaling pathway_Homo sapiens_hsa043100.27851810
143Amoebiasis_Homo sapiens_hsa051460.26899077
144Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24217237
145Cyanoamino acid metabolism_Homo sapiens_hsa004600.23591115
146Metabolic pathways_Homo sapiens_hsa011000.23429025
147Starch and sucrose metabolism_Homo sapiens_hsa005000.23413605
148PPAR signaling pathway_Homo sapiens_hsa033200.22917971
149Phosphatidylinositol signaling system_Homo sapiens_hsa040700.22069095
150Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21143986
151Glioma_Homo sapiens_hsa052140.21094853
152Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.17270459
153Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.14902589
154Tyrosine metabolism_Homo sapiens_hsa003500.12959688

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