PMEL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ketone body metabolic process (GO:1902224)9.28783659
2melanocyte differentiation (GO:0030318)8.27629336
3pigment cell differentiation (GO:0050931)7.56248608
4* pigment biosynthetic process (GO:0046148)7.33523266
5* pigment metabolic process (GO:0042440)5.64475865
6regulation of endothelial cell chemotaxis (GO:2001026)5.45349040
7neuroepithelial cell differentiation (GO:0060563)5.33050888
8endosome to melanosome transport (GO:0035646)5.16111355
9endosome to pigment granule transport (GO:0043485)5.16111355
10myotube differentiation (GO:0014902)5.07226213
11pigmentation (GO:0043473)5.04417552
12positive regulation of neuroblast proliferation (GO:0002052)4.95859240
13mesenchymal-epithelial cell signaling (GO:0060638)4.85300132
14negative regulation of hydrogen peroxide-induced cell death (GO:1903206)4.75825412
15aromatic amino acid family metabolic process (GO:0009072)4.70019363
16short-chain fatty acid metabolic process (GO:0046459)4.47273098
17negative regulation of response to reactive oxygen species (GO:1901032)4.31251717
18regulation of hydrogen peroxide-induced cell death (GO:1903205)4.27062217
19* melanosome organization (GO:0032438)4.25704713
20* pigment granule organization (GO:0048753)4.04922512
21melanosome localization (GO:0032400)4.03301761
22* melanin biosynthetic process (GO:0042438)33.6863890
23* melanin metabolic process (GO:0006582)30.3278108
24melanosome transport (GO:0032402)3.97841846
25regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.96111807
26pigment granule localization (GO:0051875)3.83560662
27establishment of melanosome localization (GO:0032401)3.82374967
28endothelial cell morphogenesis (GO:0001886)3.79903373
29* phenol-containing compound metabolic process (GO:0018958)3.78794619
30pigment granule transport (GO:0051904)3.75656957
31nerve growth factor signaling pathway (GO:0038180)3.72831524
32regulation of superoxide anion generation (GO:0032928)3.65831858
33somatic stem cell division (GO:0048103)3.63276901
34enteric nervous system development (GO:0048484)3.62574729
35establishment of pigment granule localization (GO:0051905)3.61827111
36regulation of integrin-mediated signaling pathway (GO:2001044)3.59967493
37mitotic G1 DNA damage checkpoint (GO:0031571)3.54139298
38semaphorin-plexin signaling pathway (GO:0071526)3.49445013
39regulation of neuroblast proliferation (GO:1902692)3.46264893
40basement membrane organization (GO:0071711)3.40312086
41inositol phosphate catabolic process (GO:0071545)3.26536247
42inositol phosphate dephosphorylation (GO:0046855)3.22624159
43columnar/cuboidal epithelial cell differentiation (GO:0002065)3.18834557
44calcium-mediated signaling using intracellular calcium source (GO:0035584)3.07629620
45mitotic G1/S transition checkpoint (GO:0044819)3.07361596
46positive regulation of receptor recycling (GO:0001921)3.04955932
47G1 DNA damage checkpoint (GO:0044783)3.02570610
48* secondary metabolite biosynthetic process (GO:0044550)27.4843211
49proline transport (GO:0015824)2.85346590
50peripheral nervous system development (GO:0007422)2.84095552
51negative regulation of interleukin-1 beta production (GO:0032691)2.84080429
52regulation of somitogenesis (GO:0014807)2.82553323
53retinal rod cell development (GO:0046548)2.80927100
54muscle cell migration (GO:0014812)2.80571224
55antigen processing and presentation via MHC class Ib (GO:0002475)2.79858469
56negative regulation of macroautophagy (GO:0016242)2.77482059
57cellular response to reactive nitrogen species (GO:1902170)2.75892236
58chondroitin sulfate catabolic process (GO:0030207)2.74201359
59cellular response to nitric oxide (GO:0071732)2.73538337
60regulation of protein sumoylation (GO:0033233)2.73013707
61negative regulation of transcription by competitive promoter binding (GO:0010944)2.72850638
62bone remodeling (GO:0046849)2.69728930
63negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.68363709
64dosage compensation (GO:0007549)2.65496306
65Rap protein signal transduction (GO:0032486)2.57011780
66fibroblast migration (GO:0010761)2.54460486
67negative regulation of organelle assembly (GO:1902116)2.50505201
68negative regulation of receptor-mediated endocytosis (GO:0048261)2.48441867
69barbed-end actin filament capping (GO:0051016)2.46764360
70response to epinephrine (GO:0071871)2.46763375
71positive regulation of neural precursor cell proliferation (GO:2000179)2.46608245
72regulation of sister chromatid cohesion (GO:0007063)2.45338907
73cGMP-mediated signaling (GO:0019934)2.44088211
74negative regulation of fatty acid biosynthetic process (GO:0045717)2.42652704
75dendritic spine organization (GO:0097061)2.41762871
76polyol catabolic process (GO:0046174)2.40104646
77mitotic sister chromatid segregation (GO:0000070)2.40055719
78stem cell division (GO:0017145)2.38087609
79regulation of superoxide metabolic process (GO:0090322)2.35668461
80vitamin A metabolic process (GO:0006776)2.35506359
81mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.34183108
82regulation of response to reactive oxygen species (GO:1901031)2.33989425
83response to nitric oxide (GO:0071731)2.33480781
84negative regulation of oxidative stress-induced cell death (GO:1903202)2.30830034
85pore complex assembly (GO:0046931)2.27876725
86cullin deneddylation (GO:0010388)2.27840172
87ventricular cardiac muscle cell development (GO:0055015)2.24247135
88regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.24045825
89cellular response to nerve growth factor stimulus (GO:1990090)2.23351633
90response to nerve growth factor (GO:1990089)2.23351633
91negative regulation of cellular response to oxidative stress (GO:1900408)2.21394832
92negative regulation of response to oxidative stress (GO:1902883)2.21394832
93muscle cell cellular homeostasis (GO:0046716)2.21317446
94negative regulation of TOR signaling (GO:0032007)2.20795323
95mitotic DNA damage checkpoint (GO:0044773)2.20739262
96peptidyl-proline hydroxylation (GO:0019511)2.20259688
97negative regulation of chemokine production (GO:0032682)2.19934391
98sister chromatid segregation (GO:0000819)2.17923891
99cornea development in camera-type eye (GO:0061303)2.17076294
100mitotic G2 DNA damage checkpoint (GO:0007095)2.15847122
101autophagic vacuole fusion (GO:0000046)2.15248474
102negative regulation of interleukin-1 production (GO:0032692)2.14092960
103fusion of sperm to egg plasma membrane (GO:0007342)2.12072015
104negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.11941489
105osteoclast differentiation (GO:0030316)2.11189200
106regulation of centriole replication (GO:0046599)2.10798003
107cranial nerve development (GO:0021545)2.10087404
108gluconeogenesis (GO:0006094)2.09845123
1094-hydroxyproline metabolic process (GO:0019471)2.07171351
110positive regulation of osteoblast proliferation (GO:0033690)2.06843960
111cellular response to thyroid hormone stimulus (GO:0097067)2.06089352
112regulation of apoptotic cell clearance (GO:2000425)2.05432587
113layer formation in cerebral cortex (GO:0021819)2.05234991
114regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.03787422
115regulation of cellular respiration (GO:0043457)2.03487525
116mitotic DNA integrity checkpoint (GO:0044774)2.03297586
117sialylation (GO:0097503)2.03274370
118removal of superoxide radicals (GO:0019430)2.03148064
119cellular response to superoxide (GO:0071451)2.03148064
120cellular response to oxygen radical (GO:0071450)2.03148064
121positive regulation of response to oxidative stress (GO:1902884)2.00306164
122tyrosine metabolic process (GO:0006570)15.1551734
123developmental pigmentation (GO:0048066)12.8756945
124* phenol-containing compound biosynthetic process (GO:0046189)10.4163106
125* secondary metabolic process (GO:0019748)10.1675820
126Rac protein signal transduction (GO:0016601)1.96669384
127* organic hydroxy compound biosynthetic process (GO:1901617)1.96515005
128negative regulation of fatty acid metabolic process (GO:0045922)1.93019897
129establishment of nucleus localization (GO:0040023)1.90552602
130regulation of early endosome to late endosome transport (GO:2000641)1.90245676
131behavioral response to ethanol (GO:0048149)1.89692991
132centrosome duplication (GO:0051298)1.80806653
133myelin assembly (GO:0032288)1.80521317
134glycoprotein catabolic process (GO:0006516)1.78408220
135protein K6-linked ubiquitination (GO:0085020)1.77840304
136folic acid-containing compound biosynthetic process (GO:0009396)1.76562215
137positive regulation of DNA-dependent DNA replication (GO:2000105)1.76221647
138angiogenesis involved in wound healing (GO:0060055)1.76169890
139negative regulation of histone methylation (GO:0031061)1.75192946
140positive regulation of glucose transport (GO:0010828)1.73731559
141peptidyl-lysine dimethylation (GO:0018027)1.72884345
142positive chemotaxis (GO:0050918)1.72756940
143cellular glucuronidation (GO:0052695)1.70792713
144establishment of mitotic spindle orientation (GO:0000132)1.68910449
145regulation of oxidative stress-induced cell death (GO:1903201)1.65680961
146specification of organ identity (GO:0010092)1.64990737
147negative regulation of membrane potential (GO:0045837)1.63452377
148regulation of histone H3-K9 methylation (GO:0051570)1.62298936
149positive regulation of Rap GTPase activity (GO:0032854)1.61278754
150organelle membrane fusion (GO:0090174)1.60166110
151thymus development (GO:0048538)1.59298793
152glycolytic process (GO:0006096)1.55974627
153glucuronate metabolic process (GO:0019585)1.53110233
154uronic acid metabolic process (GO:0006063)1.53110233
155regulation of short-term neuronal synaptic plasticity (GO:0048172)1.51019250
156chondroitin sulfate biosynthetic process (GO:0030206)1.50373654
157establishment of mitotic spindle localization (GO:0040001)1.48861747
158regulation of cellular response to oxidative stress (GO:1900407)1.45760209
159spinal cord association neuron differentiation (GO:0021527)1.45019757
160cerebellar Purkinje cell layer development (GO:0021680)1.44949197
161phosphorylated carbohydrate dephosphorylation (GO:0046838)1.44082894

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse9.69447402
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat9.41125716
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.27759904
4E2F7_22180533_ChIP-Seq_HELA_Human4.42576898
5EGR1_19374776_ChIP-ChIP_THP-1_Human4.39073186
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.15372533
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.09023890
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.08604913
9GATA1_22025678_ChIP-Seq_K562_Human2.61873113
10HIF1A_21447827_ChIP-Seq_MCF-7_Human2.56716127
11CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.45938810
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.45444188
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.43953734
14THAP11_20581084_ChIP-Seq_MESCs_Mouse2.43507389
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.39113866
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.36117859
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32434793
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.26662198
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.20086044
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.14018700
21TFEB_21752829_ChIP-Seq_HELA_Human2.12450025
22EGR1_19032775_ChIP-ChIP_M12_Human2.05892212
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.05035089
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.02164055
25PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.00657174
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97558591
27PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.95874173
28MITF_21258399_ChIP-Seq_MELANOMA_Human1.82859914
29MYC_19030024_ChIP-ChIP_MESCs_Mouse1.80479895
30ESR1_15608294_ChIP-ChIP_MCF-7_Human1.75736257
31ZFX_18555785_ChIP-Seq_MESCs_Mouse1.74738037
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73496698
33ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.72059683
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.70686841
35CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.63420473
36CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.60678266
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59956887
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.59494208
39ZNF263_19887448_ChIP-Seq_K562_Human1.53826483
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.53131737
41CLOCK_20551151_ChIP-Seq_293T_Human1.43749518
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42458977
43ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.39857446
44GABP_19822575_ChIP-Seq_HepG2_Human1.39802718
45DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38076355
46NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.37557074
47DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.36842574
48DCP1A_22483619_ChIP-Seq_HELA_Human1.36740451
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.36652244
50FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.36600338
51ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.33908339
52ETS1_20019798_ChIP-Seq_JURKAT_Human1.30952233
53TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30268181
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30100038
55RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29609928
56CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28478834
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28420397
58DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.28108215
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.27747078
60GABP_17652178_ChIP-ChIP_JURKAT_Human1.26945834
61CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26367146
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.26364137
63ETV2_25802403_ChIP-Seq_MESCs_Mouse1.26261737
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26093561
65AR_21909140_ChIP-Seq_LNCAP_Human1.25703349
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24991709
67EST1_17652178_ChIP-ChIP_JURKAT_Human1.24483725
68BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23044256
69XRN2_22483619_ChIP-Seq_HELA_Human1.22696325
70SOX17_20123909_ChIP-Seq_XEN_Mouse1.22547068
71CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.22235789
72WT1_19549856_ChIP-ChIP_CCG9911_Human1.21947318
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21774517
74HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21508697
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20565192
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18300193
77SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.16687159
78SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.16687159
79SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16596341
80ELK1_19687146_ChIP-ChIP_HELA_Human1.14651314
81ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09479150
82SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.09380906
83BRD4_25478319_ChIP-Seq_HGPS_Human1.08887284
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07841021
85E2F1_21310950_ChIP-Seq_MCF-7_Human1.07426062
86PPAR_26484153_Chip-Seq_NCI-H1993_Human1.06466518
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06080616
88SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.05890203
89AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05808782
90TRIM28_21343339_ChIP-Seq_HEK293_Human1.05067002
91NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04514876
92P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03984761
93EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.02547012
94CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01767338
95FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.01298121
96ATF3_27146783_Chip-Seq_COLON_Human1.00922815
97TBX20_22328084_ChIP-Seq_HEART_Mouse1.00749050
98TBX20_22080862_ChIP-Seq_HEART_Mouse1.00749050
99ESR1_20079471_ChIP-ChIP_T-47D_Human0.99831990
100ETS1_22383799_ChIP-Seq_G1ME_Mouse0.99194683
101RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.99060974
102SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97799082
103GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.97759420
104UBF1/2_26484160_Chip-Seq_HMECs_Human0.97546604
105TTF2_22483619_ChIP-Seq_HELA_Human0.96812361
106KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95757616
107FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95717785
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95638538
109PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95059113
110CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95052165
111Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.93690039
112SMC4_20622854_ChIP-Seq_HELA_Human0.93256259
113CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90594624
114DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90333632
115MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.89695468
116SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.89521252
117MYC_18555785_ChIP-Seq_MESCs_Mouse0.89036125
118PU_27001747_Chip-Seq_BMDM_Mouse0.88537033
119TP53_18474530_ChIP-ChIP_U2OS_Human0.88481371
120TBX5_21415370_ChIP-Seq_HL-1_Mouse0.88285150
121ESR2_21235772_ChIP-Seq_MCF-7_Human0.88003360
122CREB1_15753290_ChIP-ChIP_HEK293T_Human0.87965536
123KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87489664
124GATA1_26923725_Chip-Seq_HPCs_Mouse0.87440257
125E2F1_17053090_ChIP-ChIP_MCF-7_Human0.87183104
126CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87046989
127PKCTHETA_26484144_Chip-Seq_BREAST_Human0.86697595
128CJUN_26792858_Chip-Seq_BT549_Human0.86510944
129ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.86072941
130TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85605137
131ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85447278
132BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85387121
133SALL1_21062744_ChIP-ChIP_HESCs_Human0.85081163
134KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.84962887
135FOXM1_23109430_ChIP-Seq_U2OS_Human0.84834179
136MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.84239193
137SOX9_26525672_Chip-Seq_HEART_Mouse0.84175703
138FOXO3_23340844_ChIP-Seq_DLD1_Human0.83609034
139SOX2_22085726_ChIP-Seq_NPCs_Mouse0.83217208
140SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82983568
141CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.82568315
142TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.82253852
143PADI4_21655091_ChIP-ChIP_MCF-7_Human0.82139638
144SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81731167
145VDR_24763502_ChIP-Seq_THP-1_Human0.81296157
146NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.80894153
147VDR_24787735_ChIP-Seq_THP-1_Human0.80039318
148FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.79703135
149PPARA_22158963_ChIP-Seq_LIVER_Mouse0.79634489
150TP63_17297297_ChIP-ChIP_HaCaT_Human0.78177503
151CTBP1_25329375_ChIP-Seq_LNCAP_Human0.77488661
152TCF7_22412390_ChIP-Seq_EML_Mouse0.75093035
153NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.74618443
154KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.74132002
155SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.73941885
156PCGF2_27294783_Chip-Seq_NPCs_Mouse0.73498003
157SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.73088134
158TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.73067997
159MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.73036734
160RUNX1_27514584_Chip-Seq_MCF-7_Human0.72979727
161NFIB_24661679_ChIP-Seq_LUNG_Mouse0.72215398
162HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.71745434
163ISL1_27105846_Chip-Seq_CPCs_Mouse0.71347001
164RXR_22158963_ChIP-Seq_LIVER_Mouse0.71022776
165TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.70282535
166MYC_19079543_ChIP-ChIP_MESCs_Mouse0.69136867
167EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.68507156
168PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.68348289
169GF1B_26923725_Chip-Seq_HPCs_Mouse0.68016033
170EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.67554228

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation9.64948435
2* MP0000372_irregular_coat_pigmentation9.60505548
3MP0005408_hypopigmentation6.02130482
4MP0003136_yellow_coat_color5.73665885
5MP0000371_diluted_coat_color4.61445068
6MP0004381_abnormal_hair_follicle4.52091180
7MP0005257_abnormal_intraocular_pressure4.20287579
8MP0002877_abnormal_melanocyte_morpholog3.49743573
9MP0000015_abnormal_ear_pigmentation3.48097530
10MP0002095_abnormal_skin_pigmentation3.44545639
11MP0003878_abnormal_ear_physiology3.08730949
12MP0005377_hearing/vestibular/ear_phenot3.08730949
13MP0001324_abnormal_eye_pigmentation2.75772878
14MP0005075_abnormal_melanosome_morpholog2.67229979
15MP0002075_abnormal_coat/hair_pigmentati2.63156274
16MP0002102_abnormal_ear_morphology2.50093870
17MP0005174_abnormal_tail_pigmentation2.28963662
18MP0000569_abnormal_digit_pigmentation2.19819656
19MP0001186_pigmentation_phenotype2.10893027
20MP0005248_abnormal_Harderian_gland1.84539768
21MP0002938_white_spotting1.77815188
22MP0004885_abnormal_endolymph1.63639773
23MP0002638_abnormal_pupillary_reflex1.39913501
24MP0005197_abnormal_uvea_morphology1.33390973
25MP0002090_abnormal_vision1.13406756
26MP0003705_abnormal_hypodermis_morpholog1.13405263
27MP0005409_darkened_coat_color1.05604577
28MP0003806_abnormal_nucleotide_metabolis1.04324279
29MP0008260_abnormal_autophagy0.94979966
30MP0002822_catalepsy0.85310558
31MP0010094_abnormal_chromosome_stability0.79409248
32MP0003453_abnormal_keratinocyte_physiol0.72336965
33MP0010234_abnormal_vibrissa_follicle0.71221230
34MP0001293_anophthalmia0.68904018
35MP0005253_abnormal_eye_physiology0.68477206
36MP0000733_abnormal_muscle_development0.64659997
37MP0000367_abnormal_coat/_hair0.63887792
38MP0005058_abnormal_lysosome_morphology0.61453604
39MP0003646_muscle_fatigue0.61306053
40MP0002089_abnormal_postnatal_growth/wei0.60349835
41MP0003011_delayed_dark_adaptation0.57281595
42MP0001485_abnormal_pinna_reflex0.53648391
43MP0003123_paternal_imprinting0.47776701
44MP0000377_abnormal_hair_follicle0.47005039
45MP0008932_abnormal_embryonic_tissue0.45779556
46MP0006054_spinal_hemorrhage0.43897962
47MP0002177_abnormal_outer_ear0.43250266
48MP0000762_abnormal_tongue_morphology0.41789738
49MP0002092_abnormal_eye_morphology0.41475029
50MP0010307_abnormal_tumor_latency0.41253478
51MP0005023_abnormal_wound_healing0.41113480
52MP0006138_congestive_heart_failure0.38864500
53MP0005391_vision/eye_phenotype0.38739396
54MP0003566_abnormal_cell_adhesion0.37688742
55MP0009697_abnormal_copulation0.37598293
56MP0005623_abnormal_meninges_morphology0.37584260
57MP0010030_abnormal_orbit_morphology0.37112162
58MP0005187_abnormal_penis_morphology0.36123835
59MP0001188_hyperpigmentation0.35711157
60MP0005193_abnormal_anterior_eye0.35681333
61MP0001984_abnormal_olfaction0.34040472
62MP0003943_abnormal_hepatobiliary_system0.32702934
63MP0008569_lethality_at_weaning0.32605800
64MP0005551_abnormal_eye_electrophysiolog0.32128806
65MP0009840_abnormal_foam_cell0.31068788
66MP0001851_eye_inflammation0.29496958
67MP0001849_ear_inflammation0.29370957
68MP0000749_muscle_degeneration0.29020133
69MP0008770_decreased_survivor_rate0.28612410
70MP0003186_abnormal_redox_activity0.25796553
71MP0008438_abnormal_cutaneous_collagen0.25675507
72MP0003091_abnormal_cell_migration0.25208455
73MP0003567_abnormal_fetal_cardiomyocyte0.23768885
74MP0003634_abnormal_glial_cell0.22444808
75MP0000358_abnormal_cell_content/0.22245785
76MP0003111_abnormal_nucleus_morphology0.20198478
77MP0004233_abnormal_muscle_weight0.19998125
78MP0002396_abnormal_hematopoietic_system0.19931358
79MP0003950_abnormal_plasma_membrane0.19356405
80MP0004084_abnormal_cardiac_muscle0.19106918
81MP0003191_abnormal_cellular_cholesterol0.18894310
82MP0010352_gastrointestinal_tract_polyps0.18370045
83MP0001958_emphysema0.18347384
84MP0003172_abnormal_lysosome_physiology0.18116671
85MP0004197_abnormal_fetal_growth/weight/0.17226457
86MP0002751_abnormal_autonomic_nervous0.17037464
87MP0004957_abnormal_blastocyst_morpholog0.16865583
88MP0009046_muscle_twitch0.16444891
89MP0002060_abnormal_skin_morphology0.16015664
90MP0004808_abnormal_hematopoietic_stem0.14783118
91MP0004147_increased_porphyrin_level0.14323618
92MP0004924_abnormal_behavior0.13997437
93MP0005386_behavior/neurological_phenoty0.13997437
94MP0000647_abnormal_sebaceous_gland0.12365541
95MP0003385_abnormal_body_wall0.09899281
96MP0002697_abnormal_eye_size0.09889655
97MP0008007_abnormal_cellular_replicative0.09389651
98MP0001270_distended_abdomen0.08983293
99MP0002909_abnormal_adrenal_gland0.08800922
100MP0005621_abnormal_cell_physiology0.07901981
101MP0000639_abnormal_adrenal_gland0.07311275
102MP0002139_abnormal_hepatobiliary_system0.06869914
103MP0003938_abnormal_ear_development0.06342372
104MP0002752_abnormal_somatic_nervous0.05416535
105MP0001299_abnormal_eye_distance/0.03353281
106MP0003698_abnormal_male_reproductive0.03330014
107MP0001963_abnormal_hearing_physiology0.02922491
108MP0001915_intracranial_hemorrhage0.02679724
109MP0003300_gastrointestinal_ulcer0.02144450
110MP0009703_decreased_birth_body0.01257194
111MP0002229_neurodegeneration0.01119204
112MP0000955_abnormal_spinal_cord0.00756209
113MP0005164_abnormal_response_to0.00606837
114MP0000920_abnormal_myelination0.00600713
115MP0003937_abnormal_limbs/digits/tail_de0.00560104
116MP0000026_abnormal_inner_ear0.00308094
117MP0005384_cellular_phenotype-0.0335100
118MP0005508_abnormal_skeleton_morphology-0.0279697
119MP0003632_abnormal_nervous_system-0.0271150
120MP0002166_altered_tumor_susceptibility-0.0263668
121MP0000681_abnormal_thyroid_gland-0.0256219
122MP0000350_abnormal_cell_proliferation-0.0227243
123MP0000747_muscle_weakness-0.0215090
124MP0002269_muscular_atrophy-0.0214766
125MP0001697_abnormal_embryo_size-0.0155421
126MP0003077_abnormal_cell_cycle-0.0077773
127MP0005195_abnormal_posterior_eye-0.0035819
128MP0004272_abnormal_basement_membrane-0.0032179

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fovea (HP:0000493)9.93345783
2Ocular albinism (HP:0001107)9.53676343
3Iris hypopigmentation (HP:0007730)8.36275495
4Hypopigmentation of the fundus (HP:0007894)7.74275763
5Generalized hypopigmentation (HP:0007513)7.11031365
6White forelock (HP:0002211)6.48996042
7Congenital sensorineural hearing impairment (HP:0008527)6.31589898
8Subacute progressive viral hepatitis (HP:0006572)5.81599223
9Patchy hypopigmentation of hair (HP:0011365)5.79993639
10Hypoplasia of the iris (HP:0007676)5.20221849
11Cutaneous melanoma (HP:0012056)4.87336570
12Freckling (HP:0001480)4.61310203
13Heterochromia iridis (HP:0001100)4.55431430
14Generalized hypopigmentation of hair (HP:0011358)4.44184054
15Bilateral sensorineural hearing impairment (HP:0008619)4.31947687
16Aplasia/Hypoplasia affecting the fundus (HP:0008057)3.89235139
17Premature graying of hair (HP:0002216)3.86488853
18Albinism (HP:0001022)3.56280750
19Peripheral hypomyelination (HP:0007182)3.42630147
20Viral hepatitis (HP:0006562)3.32795482
21Micronodular cirrhosis (HP:0001413)3.22055001
22Hepatocellular carcinoma (HP:0001402)2.68246468
23Asymmetric septal hypertrophy (HP:0001670)2.64813219
24Melanoma (HP:0002861)2.45904132
25Mucopolysacchariduria (HP:0008155)2.20068607
26Urinary glycosaminoglycan excretion (HP:0003541)2.20068607
27Cerebral hypomyelination (HP:0006808)2.18916668
28Amblyopia (HP:0000646)2.16854296
29Abnormality of vision evoked potentials (HP:0000649)2.12660079
30Morphological abnormality of the inner ear (HP:0011390)2.10185783
31Abnormal auditory evoked potentials (HP:0006958)2.02375642
32Aplasia/Hypoplasia of the macula (HP:0008059)12.6207258
33Aplasia/Hypoplasia affecting the retina (HP:0008061)11.8333238
34Aplasia/Hypoplasia of the fovea (HP:0008060)11.7918122
35Hypoplasia of the fovea (HP:0007750)11.7918122
36Blue irides (HP:0000635)11.3606142
37Abnormality of polysaccharide metabolism (HP:0011012)1.97234289
38Abnormality of glycosaminoglycan metabolism (HP:0004371)1.97234289
39Abnormality of mucopolysaccharide metabolism (HP:0011020)1.97234289
40Facial cleft (HP:0002006)1.89638679
41Abnormality of the anterior horn cell (HP:0006802)1.89430621
42Degeneration of anterior horn cells (HP:0002398)1.89430621
43Dysostosis multiplex (HP:0000943)1.85202096
44Congenital stationary night blindness (HP:0007642)1.80396720
45Scapular winging (HP:0003691)1.80335087
46Synophrys (HP:0000664)1.80291807
47Abnormal autonomic nervous system physiology (HP:0012332)1.79934617
48Rhabdomyosarcoma (HP:0002859)1.79054248
49Abnormal gallbladder physiology (HP:0012438)1.77742829
50Cholecystitis (HP:0001082)1.77742829
51Cerebral inclusion bodies (HP:0100314)1.74358759
52Abnormality of glycolipid metabolism (HP:0010969)1.73648509
53Abnormality of liposaccharide metabolism (HP:0010968)1.73648509
54Abnormality of glycosphingolipid metabolism (HP:0004343)1.73648509
55Decreased motor nerve conduction velocity (HP:0003431)1.73446473
56Renal cell carcinoma (HP:0005584)1.72402785
57Cerebral aneurysm (HP:0004944)1.70530439
58Adrenal hypoplasia (HP:0000835)1.68176946
59Underdeveloped nasal alae (HP:0000430)1.67617650
60Vertebral compression fractures (HP:0002953)1.66975184
61Spastic diplegia (HP:0001264)1.66088124
62Hypermelanotic macule (HP:0001034)1.64180279
63J-shaped sella turcica (HP:0002680)1.61658320
64Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.61311593
65Absent epiphyses (HP:0010577)1.61311593
66Megalencephaly (HP:0001355)1.61264570
67Visual hallucinations (HP:0002367)1.58632092
68Decreased lacrimation (HP:0000633)1.58425326
69Melanocytic nevus (HP:0000995)1.58124701
70Impaired proprioception (HP:0010831)1.51397936
71Hepatitis (HP:0012115)1.44680370
72Termporal pattern (HP:0011008)1.43065257
73Insidious onset (HP:0003587)1.43065257
74Horizontal nystagmus (HP:0000666)1.41608408
75Lip pit (HP:0100267)1.39961828
76Ulnar claw (HP:0001178)1.39554041
77Astigmatism (HP:0000483)1.39433286
78Frequent falls (HP:0002359)1.38417077
79Protrusio acetabuli (HP:0003179)1.36818765
80Aplasia cutis congenita (HP:0001057)1.35693159
81Abnormality of the anterior chamber (HP:0000593)1.34670393
82Tongue fasciculations (HP:0001308)1.33718684
83Tented upper lip vermilion (HP:0010804)1.33449917
84Morphological abnormality of the middle ear (HP:0008609)1.31626460
85Action tremor (HP:0002345)1.28346682
86Exercise-induced muscle cramps (HP:0003710)1.27910922
87Large for gestational age (HP:0001520)1.26313702
88Supernumerary ribs (HP:0005815)1.26022441
89Abnormality of the nasal septum (HP:0000419)1.25955243
90Photophobia (HP:0000613)1.24074077
91Supernumerary nipples (HP:0002558)1.22483952
92Narrow nasal bridge (HP:0000446)1.21426884
93Conjunctival hamartoma (HP:0100780)1.21011211
94Long toe (HP:0010511)1.19272450
95Neoplasm of striated muscle (HP:0009728)1.18440021
96Hand muscle atrophy (HP:0009130)1.17887103
97Hypoplasia of the capital femoral epiphysis (HP:0003090)1.17291902
98Fibular hypoplasia (HP:0003038)1.15797487
99Hamartoma of the eye (HP:0010568)1.14734633
100Neoplasm of the oral cavity (HP:0100649)1.12768603
101Abnormal pupillary function (HP:0007686)1.12115283
102Hypermetropia (HP:0000540)1.10885474
103Myelomeningocele (HP:0002475)1.10830674
104Coarse hair (HP:0002208)1.10807841
105Nasal speech (HP:0001611)1.10802424
106Ovoid vertebral bodies (HP:0003300)1.10235646
107Postural tremor (HP:0002174)1.09807985
108Neoplasm of the liver (HP:0002896)1.09322057
109Muscle fibrillation (HP:0010546)1.08856467
110Supernumerary bones of the axial skeleton (HP:0009144)1.07877861
111Intestinal atresia (HP:0011100)1.07553914
112Akinesia (HP:0002304)1.07539844
113Epidermoid cyst (HP:0200040)1.07286371
114Hypoplastic ischia (HP:0003175)1.06783093
115Loss of speech (HP:0002371)1.06496608
116Spastic paraplegia (HP:0001258)1.05995854
117Abnormality of the salivary glands (HP:0010286)1.05989800
118Spinal muscular atrophy (HP:0007269)1.05944461
119Poor head control (HP:0002421)1.05651516
120Ulnar deviation of finger (HP:0009465)1.04481331
121Joint stiffness (HP:0001387)1.03085672
122Leukodystrophy (HP:0002415)1.02264542
123Paraparesis (HP:0002385)1.01978519
124Decreased electroretinogram (ERG) amplitude (HP:0000654)1.01715610
125Intestinal polyposis (HP:0200008)1.01266652
126CNS hypomyelination (HP:0003429)1.01039848
127Cholelithiasis (HP:0001081)1.00243759
128Peripheral demyelination (HP:0011096)0.99637344
129Tracheomalacia (HP:0002779)0.99609027
130Synostosis of carpal bones (HP:0005048)0.97490318
131Premature rupture of membranes (HP:0001788)0.97302549
132Upper limb amyotrophy (HP:0009129)0.97077390
133Distal upper limb amyotrophy (HP:0007149)0.97077390
134Aortic aneurysm (HP:0004942)0.96774510
135Spastic paraparesis (HP:0002313)0.96446587
136Overlapping toe (HP:0001845)0.96014624
137Parkinsonism with favorable response to dopaminergic medication (HP:0002548)0.93907295
138Asymmetry of the thorax (HP:0001555)0.92321480
139Abnormality of the shoulder girdle musculature (HP:0001435)0.92114096
140Atelectasis (HP:0100750)0.91961541
141Hypopigmented skin patches (HP:0001053)0.91858236
142Paraplegia (HP:0010550)0.91616351
143Spontaneous hematomas (HP:0007420)0.91574548
144Distal sensory impairment (HP:0002936)0.88314470
145Decreased central vision (HP:0007663)0.88102629
146Carpal synostosis (HP:0009702)0.87940237
147Vascular tortuosity (HP:0004948)0.85710041
148Bladder diverticulum (HP:0000015)0.85435187
149Proximal amyotrophy (HP:0007126)0.84288093
150Acrocyanosis (HP:0001063)0.83308892
151Upper limb muscle weakness (HP:0003484)0.83276890
152Esophageal varix (HP:0002040)0.83062642
153Bladder neoplasm (HP:0009725)0.82856073
154Bladder carcinoma (HP:0002862)0.82856073
155Exostoses (HP:0100777)0.79973287
156Abnormal hemoglobin (HP:0011902)0.79000246
157Alacrima (HP:0000522)0.78752583

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MET5.60037594
2PDK24.43678213
3MARK34.32776535
4BMX3.95655312
5PKN23.70533784
6WEE13.49173349
7TRIB32.58273278
8PLK22.29443845
9EIF2AK12.29328200
10PRKCH2.16701096
11EPHA32.09898501
12MST1R13.0746644
13ICK1.80434372
14MAP3K31.67408531
15SCYL21.62853325
16ERBB31.51648089
17PRKD31.45842641
18BMPR21.40237729
19DDR21.28811138
20CDK31.18915279
21PLK31.14396338
22SIK31.12963135
23NME21.11557342
24TRIM281.10901512
25MAP3K21.05199333
26LATS11.05048025
27GRK61.02518560
28PTK2B1.00452673
29BMPR1B0.99645746
30ERBB20.96661719
31MAPKAPK30.94042868
32GRK50.92263774
33MATK0.91398149
34BRSK10.91365388
35FLT30.91207891
36NEK60.87200674
37PLK10.86451336
38TTK0.86139139
39NEK10.84556211
40LRRK20.84045708
41GSK3A0.83953882
42PTK60.83858351
43TTN0.74793120
44ATR0.68106785
45CSNK1G10.63326070
46CAMKK10.63083129
47CSNK1G30.60012654
48CSNK1A1L0.59624586
49TGFBR20.58846520
50FGFR40.57563428
51CDK180.57300786
52RPS6KB20.56520944
53EIF2AK30.56195670
54RET0.56020519
55ACVR1B0.53624282
56ABL20.52101878
57CDK150.51070660
58CDK11A0.50602608
59PAK40.48262889
60FER0.47944491
61KSR20.46816966
62BUB10.45120954
63CDK140.43879969
64TBK10.43105699
65CSNK1G20.42908974
66EEF2K0.42515067
67KIT0.42205797
68PDGFRA0.41560331
69ILK0.39570204
70CDK70.38970026
71KSR10.38751174
72CAMKK20.37891838
73AKT20.36604163
74MINK10.36137150
75CCNB10.35687181
76ATM0.34067924
77CDK60.33829691
78RIPK10.33719647
79DYRK1A0.33585900
80UHMK10.33340608
81PRKG20.31841792
82MAPK100.29527446
83FGFR30.29057389
84TLK10.28663991
85CLK10.27898067
86LIMK10.27615212
87MAP3K130.26647822
88INSR0.25719060
89MAP3K110.25582071
90ERBB40.25106913
91PAK60.24241695
92PRKD20.24029899
93NTRK20.22951102
94ALK0.22916214
95DMPK0.22499045
96FGR0.22413342
97TYRO30.22028487
98PRKCE0.21876466
99MAP3K90.21832352
100MAP3K80.21773962
101ZAP700.21757450
102FRK0.21747761
103CSNK1A10.21271773
104DYRK1B0.20889683
105EGFR0.20558060
106FYN0.19617461
107PRKCZ0.19545557
108MAP4K10.19328206
109CDK10.19321151
110EPHB10.18688432
111MAPK120.18367577
112MAP2K10.17976878
113RPS6KA10.16283591
114BRSK20.16007702
115STK40.15536731
116RAF10.14420192
117NEK90.13864554
118CDK40.13507371
119CHEK20.12803445
120PDGFRB0.12566488
121BLK0.12243940
122LMTK20.12079677
123ABL10.11822158
124LATS20.11007628
125NEK20.10838551
126PAK20.10829046
127IGF1R0.10426653
128FGFR10.10398961
129STK30.10015423
130CAMK1D0.09809125
131MAPK30.09657299
132SRC0.09106396
133CSNK1D0.08627908
134NTRK10.08366293
135SGK30.08206341
136PAK30.08062425
137PTK20.07475649
138CDC70.07005869
139TRPM70.06752229
140FGFR20.06623705
141PRKAA20.05607770
142SGK20.05121384
143PRKACB0.04297384
144TYK20.04189048
145MAPK110.04095792
146JAK20.02624924
147AKT10.02572641
148NUAK10.02418819
149JAK10.02397012
150MAP3K10.02380308
151PRKCQ0.01944568
152LYN0.01940568
153STK380.01931930
154PRKD10.01898796
155MOS0.01842631

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005314.76205245
2Melanogenesis_Homo sapiens_hsa049164.09469848
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.15892155
4Non-homologous end-joining_Homo sapiens_hsa034503.13630998
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.77023722
6Central carbon metabolism in cancer_Homo sapiens_hsa052302.61884788
7Galactose metabolism_Homo sapiens_hsa000522.26465783
8Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.14190097
9Melanoma_Homo sapiens_hsa052182.03595604
10Tyrosine metabolism_Homo sapiens_hsa0035010.5285352
11Renal cell carcinoma_Homo sapiens_hsa052111.93314644
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.86586355
13Homologous recombination_Homo sapiens_hsa034401.77332672
14Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.75487527
15Mismatch repair_Homo sapiens_hsa034301.68625942
16Cell cycle_Homo sapiens_hsa041101.64957578
17Fatty acid elongation_Homo sapiens_hsa000621.55766605
18Adherens junction_Homo sapiens_hsa045201.52808823
19Thyroid cancer_Homo sapiens_hsa052161.49591627
20Biosynthesis of amino acids_Homo sapiens_hsa012301.48453747
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36208776
22Proteasome_Homo sapiens_hsa030501.33953268
23Fructose and mannose metabolism_Homo sapiens_hsa000511.32955447
24DNA replication_Homo sapiens_hsa030301.30464618
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29922869
26Starch and sucrose metabolism_Homo sapiens_hsa005001.28336058
27One carbon pool by folate_Homo sapiens_hsa006701.26711915
28Oxidative phosphorylation_Homo sapiens_hsa001901.24525610
29Parkinsons disease_Homo sapiens_hsa050121.23082586
30Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.17638716
31Protein export_Homo sapiens_hsa030601.15251472
32Pentose phosphate pathway_Homo sapiens_hsa000301.15122066
33Synaptic vesicle cycle_Homo sapiens_hsa047211.12828051
34Alzheimers disease_Homo sapiens_hsa050101.10650153
35Glutathione metabolism_Homo sapiens_hsa004801.09909158
36Systemic lupus erythematosus_Homo sapiens_hsa053221.08821342
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08387483
38Lysosome_Homo sapiens_hsa041421.07836265
39Malaria_Homo sapiens_hsa051441.07481140
40Sphingolipid metabolism_Homo sapiens_hsa006001.06149075
41HIF-1 signaling pathway_Homo sapiens_hsa040661.04250975
42Carbon metabolism_Homo sapiens_hsa012001.02501155
43Vitamin B6 metabolism_Homo sapiens_hsa007501.01803827
44Fanconi anemia pathway_Homo sapiens_hsa034600.99859566
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98201938
46Pyruvate metabolism_Homo sapiens_hsa006200.92262862
47Vibrio cholerae infection_Homo sapiens_hsa051100.89676453
48Base excision repair_Homo sapiens_hsa034100.87725849
49MicroRNAs in cancer_Homo sapiens_hsa052060.87095135
50N-Glycan biosynthesis_Homo sapiens_hsa005100.86317853
51Small cell lung cancer_Homo sapiens_hsa052220.86295509
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85388462
53Proteoglycans in cancer_Homo sapiens_hsa052050.84954446
54Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84332888
55Collecting duct acid secretion_Homo sapiens_hsa049660.81553313
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79352878
57Focal adhesion_Homo sapiens_hsa045100.74715737
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70786888
59mTOR signaling pathway_Homo sapiens_hsa041500.70300173
60Glioma_Homo sapiens_hsa052140.69801002
61Chronic myeloid leukemia_Homo sapiens_hsa052200.68838506
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65283167
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.65094228
64Axon guidance_Homo sapiens_hsa043600.64870675
65Huntingtons disease_Homo sapiens_hsa050160.63710858
66RNA transport_Homo sapiens_hsa030130.63260738
67Lysine degradation_Homo sapiens_hsa003100.61890327
68Viral carcinogenesis_Homo sapiens_hsa052030.61739311
69Nitrogen metabolism_Homo sapiens_hsa009100.59416985
70Prostate cancer_Homo sapiens_hsa052150.58985295
71Osteoclast differentiation_Homo sapiens_hsa043800.56542725
72Sulfur relay system_Homo sapiens_hsa041220.56208288
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.56137412
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55327955
75Alcoholism_Homo sapiens_hsa050340.51906676
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50846792
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.50550489
78VEGF signaling pathway_Homo sapiens_hsa043700.50293656
79Fatty acid metabolism_Homo sapiens_hsa012120.50040972
80Endometrial cancer_Homo sapiens_hsa052130.49294477
81Estrogen signaling pathway_Homo sapiens_hsa049150.46914840
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45661420
83Inositol phosphate metabolism_Homo sapiens_hsa005620.45469739
84Nucleotide excision repair_Homo sapiens_hsa034200.44649185
85ABC transporters_Homo sapiens_hsa020100.44226147
86Prolactin signaling pathway_Homo sapiens_hsa049170.43202108
87Bile secretion_Homo sapiens_hsa049760.43057574
88Phenylalanine metabolism_Homo sapiens_hsa003600.41827600
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41560693
90Glucagon signaling pathway_Homo sapiens_hsa049220.40023751
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38597586
92Insulin signaling pathway_Homo sapiens_hsa049100.37695006
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.37610739
94mRNA surveillance pathway_Homo sapiens_hsa030150.37518854
95RNA degradation_Homo sapiens_hsa030180.36830558
96Rap1 signaling pathway_Homo sapiens_hsa040150.36565826
97ErbB signaling pathway_Homo sapiens_hsa040120.36339563
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35857855
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35780981
100Hepatitis B_Homo sapiens_hsa051610.35087888
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35012517
102Butanoate metabolism_Homo sapiens_hsa006500.34655669
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.33352386
104p53 signaling pathway_Homo sapiens_hsa041150.32970538
105Hippo signaling pathway_Homo sapiens_hsa043900.32652674
106Folate biosynthesis_Homo sapiens_hsa007900.32385723
107Fat digestion and absorption_Homo sapiens_hsa049750.32019820
108Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.31825708
109Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30578769
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30092418
111Steroid biosynthesis_Homo sapiens_hsa001000.29051841
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28512868
113Ras signaling pathway_Homo sapiens_hsa040140.28284379
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28031584
115Colorectal cancer_Homo sapiens_hsa052100.27655621
116Pyrimidine metabolism_Homo sapiens_hsa002400.27123053
117Pathways in cancer_Homo sapiens_hsa052000.26625923
118Tight junction_Homo sapiens_hsa045300.26307570
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25927737
120Measles_Homo sapiens_hsa051620.25463945
121Linoleic acid metabolism_Homo sapiens_hsa005910.25036796
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24796918
123Arginine biosynthesis_Homo sapiens_hsa002200.24026949
124Oocyte meiosis_Homo sapiens_hsa041140.24019708
125Cyanoamino acid metabolism_Homo sapiens_hsa004600.23604165
126Insulin resistance_Homo sapiens_hsa049310.22953537
127AMPK signaling pathway_Homo sapiens_hsa041520.22057350
128Spliceosome_Homo sapiens_hsa030400.21716875
129Non-small cell lung cancer_Homo sapiens_hsa052230.21517103
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19917034
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.19587227
132Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.18677093
133Phagosome_Homo sapiens_hsa041450.18100623
134Propanoate metabolism_Homo sapiens_hsa006400.17967507
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.16866658
136Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.16861473
137Other glycan degradation_Homo sapiens_hsa005110.16777831
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.16488262
139FoxO signaling pathway_Homo sapiens_hsa040680.16389847
140Metabolic pathways_Homo sapiens_hsa011000.14808133
141Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.14775091
142Platelet activation_Homo sapiens_hsa046110.13755322
143Endocytosis_Homo sapiens_hsa041440.12689348
144Selenocompound metabolism_Homo sapiens_hsa004500.12134309
145Mineral absorption_Homo sapiens_hsa049780.11625718
146Pancreatic cancer_Homo sapiens_hsa052120.10596019
147Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.09077417
148Acute myeloid leukemia_Homo sapiens_hsa052210.08793924

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