PMEPA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)6.94179874
2protein heterotrimerization (GO:0070208)4.67027025
3bundle of His cell to Purkinje myocyte communication (GO:0086069)4.62940703
4collagen fibril organization (GO:0030199)4.62883456
5chondrocyte proliferation (GO:0035988)4.52016002
6dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.47525906
7skin morphogenesis (GO:0043589)4.25091463
8regulation of transforming growth factor beta2 production (GO:0032909)4.02120406
9endothelial cell chemotaxis (GO:0035767)3.90667826
10semaphorin-plexin signaling pathway (GO:0071526)3.84206758
11endodermal cell differentiation (GO:0035987)3.83656065
12regulation of apoptotic process involved in morphogenesis (GO:1902337)3.81707140
13cell adhesion mediated by integrin (GO:0033627)3.76530815
14cell-substrate adherens junction assembly (GO:0007045)3.69259421
15focal adhesion assembly (GO:0048041)3.69259421
16COPI coating of Golgi vesicle (GO:0048205)3.67557793
17Golgi transport vesicle coating (GO:0048200)3.67557793
18sequestering of extracellular ligand from receptor (GO:0035581)3.63570748
19wound healing, spreading of epidermal cells (GO:0035313)3.60196790
20mammary gland development (GO:0030879)3.54040846
21positive regulation of endothelial cell apoptotic process (GO:2000353)3.50533466
22regulation of water loss via skin (GO:0033561)3.48723453
23negative regulation of keratinocyte proliferation (GO:0010839)3.46363006
24activation of Rac GTPase activity (GO:0032863)3.46184745
25retina vasculature morphogenesis in camera-type eye (GO:0061299)3.44244669
26regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.39359435
27stress fiber assembly (GO:0043149)3.38080733
28muscle cell migration (GO:0014812)3.30614651
29lung vasculature development (GO:0060426)3.28455696
30branching involved in mammary gland duct morphogenesis (GO:0060444)3.25132470
31lung lobe morphogenesis (GO:0060463)3.24554760
32negative regulation of smooth muscle cell migration (GO:0014912)3.20965000
33extracellular fibril organization (GO:0043206)3.16555459
34negative regulation of fatty acid transport (GO:2000192)3.11997108
35dermatan sulfate biosynthetic process (GO:0030208)3.10815205
36cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.08054501
37virion attachment to host cell (GO:0019062)3.07115129
38adhesion of symbiont to host cell (GO:0044650)3.07115129
39collagen metabolic process (GO:0032963)3.06400041
40bone trabecula formation (GO:0060346)3.04506322
41collagen catabolic process (GO:0030574)3.02418078
42mesodermal cell differentiation (GO:0048333)2.99664072
43plasma membrane repair (GO:0001778)2.99179843
44substrate-dependent cell migration (GO:0006929)2.98814674
45cell junction assembly (GO:0034329)2.95051268
46negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.93772055
47keratinocyte proliferation (GO:0043616)2.93038522
48multicellular organismal macromolecule metabolic process (GO:0044259)2.91540935
49regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.91341268
50hemidesmosome assembly (GO:0031581)2.91002147
51establishment of skin barrier (GO:0061436)2.89670144
52hypotonic response (GO:0006971)2.87761916
53mesenchymal-epithelial cell signaling (GO:0060638)2.87080587
54regulation of cardioblast differentiation (GO:0051890)2.86514593
55protein retention in ER lumen (GO:0006621)2.86510368
56planar cell polarity pathway involved in neural tube closure (GO:0090179)2.83779541
57vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.83191099
58chondrocyte development (GO:0002063)2.82913687
59extracellular matrix disassembly (GO:0022617)2.82793814
60cell proliferation involved in metanephros development (GO:0072203)2.82303011
61maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.81489846
62cell junction organization (GO:0034330)2.80755022
63cardiac right ventricle morphogenesis (GO:0003215)2.80241077
64wound healing, spreading of cells (GO:0044319)2.79201781
65protein localization to endosome (GO:0036010)2.79020944
66cortical actin cytoskeleton organization (GO:0030866)2.77962657
67positive regulation of astrocyte differentiation (GO:0048711)2.77872348
68positive regulation of epidermal cell differentiation (GO:0045606)2.77108889
69dermatan sulfate metabolic process (GO:0030205)2.76816521
70surfactant homeostasis (GO:0043129)2.76647511
71multicellular organismal catabolic process (GO:0044243)2.76594404
72extracellular matrix assembly (GO:0085029)2.75215621
73endothelial cell morphogenesis (GO:0001886)2.74724592
74axon extension involved in axon guidance (GO:0048846)2.74226539
75neuron projection extension involved in neuron projection guidance (GO:1902284)2.74226539
76craniofacial suture morphogenesis (GO:0097094)2.74115959
77cell-substrate junction assembly (GO:0007044)2.72618735
78regulation of cell proliferation involved in kidney development (GO:1901722)2.72227490
79multicellular organismal metabolic process (GO:0044236)2.72213181
80epithelial cell-cell adhesion (GO:0090136)2.70177874
81glomerular basement membrane development (GO:0032836)2.69675692
82protein autoprocessing (GO:0016540)2.69536431
83ear development (GO:0043583)2.69130208
84positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.68561292
85regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.68518556
86positive regulation of keratinocyte differentiation (GO:0045618)2.68036369
87fibril organization (GO:0097435)2.66298843
88chemical homeostasis within a tissue (GO:0048875)2.65530555
89cortical cytoskeleton organization (GO:0030865)2.65422189
90actin filament bundle assembly (GO:0051017)2.65091992
91actin filament bundle organization (GO:0061572)2.65091992
92protein localization to cell surface (GO:0034394)2.63204945
93negative regulation of catenin import into nucleus (GO:0035414)2.63142120
94cell migration involved in sprouting angiogenesis (GO:0002042)2.63073494
95intestinal epithelial cell development (GO:0060576)2.62650742
96tight junction assembly (GO:0070830)2.62625991
97positive regulation of blood vessel endothelial cell migration (GO:0043536)2.62601096
98renal filtration (GO:0097205)2.61702619
99regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.59652681
100apoptotic cell clearance (GO:0043277)2.59498537
101negative regulation of chondrocyte differentiation (GO:0032331)2.57594359
102cell proliferation involved in kidney development (GO:0072111)2.57563829
103establishment of protein localization to plasma membrane (GO:0090002)2.57545504
104positive regulation of protein localization to plasma membrane (GO:1903078)2.56738959
105membrane protein ectodomain proteolysis (GO:0006509)2.56640358
106positive regulation of epidermis development (GO:0045684)2.56475558
107positive regulation of osteoblast proliferation (GO:0033690)2.56085202
108multicellular organismal water homeostasis (GO:0050891)2.55205655
109regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.54919260
110camera-type eye morphogenesis (GO:0048593)2.54746210
111extracellular matrix organization (GO:0030198)2.53960020
112membrane raft organization (GO:0031579)2.53812734
113adherens junction organization (GO:0034332)2.52821205
114extracellular structure organization (GO:0043062)2.52551613
115cellular response to vitamin (GO:0071295)2.52082127
116gap junction assembly (GO:0016264)2.51662409
117basement membrane organization (GO:0071711)2.51561015
118negative regulation of cell fate specification (GO:0009996)2.51263379
119regulation of p38MAPK cascade (GO:1900744)2.50545551
120lymphangiogenesis (GO:0001946)2.50243166
121regulation of receptor binding (GO:1900120)2.48895492
122negative regulation of cartilage development (GO:0061037)2.48495316
123cytoskeletal anchoring at plasma membrane (GO:0007016)2.48229617
124actin filament depolymerization (GO:0030042)2.48033486
125protein targeting to plasma membrane (GO:0072661)2.47887099
126apical protein localization (GO:0045176)2.47758540
127asymmetric protein localization (GO:0008105)2.47436919
128cell differentiation involved in embryonic placenta development (GO:0060706)2.46235676
129peptidyl-proline hydroxylation (GO:0019511)2.45489749
130cell-cell junction assembly (GO:0007043)2.45298584
131regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.44448394
132negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.44426083
133metanephric mesenchyme development (GO:0072075)2.43986476
134hippo signaling (GO:0035329)2.42914148
135L-serine transport (GO:0015825)2.42051163
136platelet-derived growth factor receptor signaling pathway (GO:0048008)2.38691031
137heart valve morphogenesis (GO:0003179)2.37746388
138positive regulation of epithelial to mesenchymal transition (GO:0010718)2.37722835
139regulation of smooth muscle cell migration (GO:0014910)2.36959190
140regulation of cartilage development (GO:0061035)2.36240870
141adhesion of symbiont to host (GO:0044406)2.36132468
142vascular endothelial growth factor signaling pathway (GO:0038084)2.35654533
143glial cell migration (GO:0008347)2.34649233
144cardiac epithelial to mesenchymal transition (GO:0060317)2.34270158
145positive regulation of metanephros development (GO:0072216)2.33739043
146wound healing (GO:0042060)2.31886057
147adherens junction assembly (GO:0034333)2.30358456
148atrioventricular valve morphogenesis (GO:0003181)2.29154528
149response to gravity (GO:0009629)2.28800320
150positive regulation of cartilage development (GO:0061036)2.28506749
151branching involved in salivary gland morphogenesis (GO:0060445)2.28015092
152pattern specification involved in kidney development (GO:0061004)2.27620311
153positive regulation of axon extension (GO:0045773)2.27189292
154response to fluid shear stress (GO:0034405)2.27100142
155kidney mesenchyme development (GO:0072074)2.25611674
156face morphogenesis (GO:0060325)2.24220821
157keratan sulfate catabolic process (GO:0042340)2.22949314
158glomerular filtration (GO:0003094)2.22800120
159short-term memory (GO:0007614)2.22712121
160regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.22165150
161cellular response to vitamin D (GO:0071305)2.20236395
162cranial suture morphogenesis (GO:0060363)2.19607376
163negative regulation of anoikis (GO:2000811)2.18880820
164substrate adhesion-dependent cell spreading (GO:0034446)2.17974351
165regulation of collagen metabolic process (GO:0010712)2.17872820
166regulation of axon extension involved in axon guidance (GO:0048841)2.17383890

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.47221414
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.55977783
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.25163829
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.47183542
5KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.41869825
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.13381315
7ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.13028698
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.11993602
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.11993602
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.11832278
11CLOCK_20551151_ChIP-Seq_293T_Human2.02148765
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.00242509
13* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.99958988
14KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.99046547
15EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.99022463
16WT1_19549856_ChIP-ChIP_CCG9911_Human1.98593552
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.97880656
18TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.97624629
19SMAD_19615063_ChIP-ChIP_OVARY_Human1.97508792
20EP300_21415370_ChIP-Seq_HL-1_Mouse1.96520970
21WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.93806674
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.92783934
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.91891678
24* CJUN_26792858_Chip-Seq_BT549_Human1.90897003
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.87729232
26RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.82406801
27ATF3_27146783_Chip-Seq_COLON_Human1.79208201
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.78713995
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.77150212
30* RUNX1_27514584_Chip-Seq_MCF-7_Human1.76637733
31JARID2_20064375_ChIP-Seq_MESCs_Mouse1.75816435
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.74495254
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.73852190
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72427807
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.70708465
36* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.69260205
37HIF1A_21447827_ChIP-Seq_MCF-7_Human1.67949605
38AR_21572438_ChIP-Seq_LNCaP_Human1.64708560
39TP53_18474530_ChIP-ChIP_U2OS_Human1.58615591
40EZH2_27304074_Chip-Seq_ESCs_Mouse1.56794402
41NRF2_20460467_ChIP-Seq_MEFs_Mouse1.56458769
42NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.56458769
43* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.54745126
44AR_21909140_ChIP-Seq_LNCAP_Human1.51737348
45* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.51659563
46SOX2_27498859_Chip-Seq_STOMACH_Mouse1.51269544
47CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.50995731
48PPAR_26484153_Chip-Seq_NCI-H1993_Human1.50531916
49* LXR_22292898_ChIP-Seq_THP-1_Human1.50423956
50TP53_16413492_ChIP-PET_HCT116_Human1.48846981
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.45039646
52DROSHA_22980978_ChIP-Seq_HELA_Human1.44636883
53* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.44399508
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38961910
55* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38724528
56RNF2_27304074_Chip-Seq_ESCs_Mouse1.38492010
57FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.36890551
58NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.36307899
59TP53_20018659_ChIP-ChIP_R1E_Mouse1.35662376
60* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.33973551
61BRD4_25478319_ChIP-Seq_HGPS_Human1.33615128
62EZH2_27294783_Chip-Seq_ESCs_Mouse1.31901959
63ESR1_21235772_ChIP-Seq_MCF-7_Human1.30750423
64* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.29150269
65SOX2_20726797_ChIP-Seq_SW620_Human1.28794911
66SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28534118
67SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.28371115
68SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.28371115
69* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28311210
70KDM2B_26808549_Chip-Seq_K562_Human1.28277564
71SMC1_22415368_ChIP-Seq_MEFs_Mouse1.27521563
72SOX9_24532713_ChIP-Seq_HFSC_Mouse1.26703944
73FOXO3_23340844_ChIP-Seq_DLD1_Human1.26341211
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26031651
75NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25987725
76GATA6_25053715_ChIP-Seq_YYC3_Human1.25594086
77IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24207850
78ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23947191
79EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23186471
80ELK3_25401928_ChIP-Seq_HUVEC_Human1.22548188
81TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22456599
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21958113
83AHR_22903824_ChIP-Seq_MCF-7_Human1.21775534
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20798523
85ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20496287
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20264610
87GATA3_24758297_ChIP-Seq_MCF-7_Human1.19800700
88ESR1_20079471_ChIP-ChIP_T-47D_Human1.19328270
89TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19275099
90GATA2_21666600_ChIP-Seq_HMVEC_Human1.19166400
91* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18470509
92* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17092658
93ERG_21242973_ChIP-ChIP_JURKAT_Human1.16728848
94* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15069512
95KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14834614
96EZH2_22144423_ChIP-Seq_EOC_Human1.14473321
97TP53_22127205_ChIP-Seq_IMR90_Human1.12645061
98TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11960266
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11167364
100* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10541317
101* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10128738
102GBX2_23144817_ChIP-Seq_PC3_Human1.09732927
103ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08886313
104CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08728203
105RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08454180
106NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07872995
107PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.07738303
108RING1B_27294783_Chip-Seq_NPCs_Mouse1.05823864
109UBF1/2_26484160_Chip-Seq_HMECs_Human1.02270712
110TBX20_22080862_ChIP-Seq_HEART_Mouse1.02018080
111TBX20_22328084_ChIP-Seq_HEART_Mouse1.02018080
112EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.01901377
113VDR_24787735_ChIP-Seq_THP-1_Human1.01415609
114CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01043493
115ISL1_27105846_Chip-Seq_CPCs_Mouse1.00639142
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00360253
117UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00098473
118PIAS1_25552417_ChIP-Seq_VCAP_Human0.99983429
119* TCF7_22412390_ChIP-Seq_EML_Mouse0.99515773
120FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98987505
121RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98716561
122PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97674972
123ARNT_22903824_ChIP-Seq_MCF-7_Human0.97629336
124RING1B_27294783_Chip-Seq_ESCs_Mouse0.96725035
125KLF5_25053715_ChIP-Seq_YYC3_Human0.96166142
126ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95568510
127ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95534321
128* TP53_23651856_ChIP-Seq_MEFs_Mouse0.95416251
129SMC4_20622854_ChIP-Seq_HELA_Human0.95062167
130TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95004981
131ZNF263_19887448_ChIP-Seq_K562_Human0.93081524
132CDX2_20551321_ChIP-Seq_CACO-2_Human0.92663609
133RACK7_27058665_Chip-Seq_MCF-7_Human0.92353534
134* SMAD3_21741376_ChIP-Seq_HESCs_Human0.91894788
135* TP63_22573176_ChIP-Seq_HFKS_Human0.91740161
136RXR_22108803_ChIP-Seq_LS180_Human0.90743776
137SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90584421
138KDM2B_26808549_Chip-Seq_DND41_Human0.90323636
139ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90270437
140TET1_21490601_ChIP-Seq_MESCs_Mouse0.90024029
141TET1_21451524_ChIP-Seq_MESCs_Mouse0.89773451
142EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89720330
143CREB1_26743006_Chip-Seq_LNCaP_Human0.89108689
144POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87857984
145TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85913702
146PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85424822
147GATA4_25053715_ChIP-Seq_YYC3_Human0.84596612

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.69539919
2MP0005275_abnormal_skin_tensile4.32305536
3MP0010234_abnormal_vibrissa_follicle3.89083645
4MP0005503_abnormal_tendon_morphology3.87879308
5MP0000579_abnormal_nail_morphology3.72398692
6MP0005623_abnormal_meninges_morphology3.48151579
7MP0003279_aneurysm3.29774743
8MP0000537_abnormal_urethra_morphology3.18859650
9MP0004272_abnormal_basement_membrane2.97443728
10MP0003705_abnormal_hypodermis_morpholog2.81693905
11MP0003453_abnormal_keratinocyte_physiol2.68644876
12MP0001849_ear_inflammation2.68208854
13MP0001958_emphysema2.67284390
14MP0002796_impaired_skin_barrier2.65988822
15MP0005409_darkened_coat_color2.41979568
16MP0003566_abnormal_cell_adhesion2.40735044
17MP0000467_abnormal_esophagus_morphology2.21676896
18MP0003091_abnormal_cell_migration2.05498995
19MP0005508_abnormal_skeleton_morphology2.03515291
20MP0009384_cardiac_valve_regurgitation1.94802864
21MP0005501_abnormal_skin_physiology1.94478677
22MP0010678_abnormal_skin_adnexa1.91421305
23MP0009250_abnormal_appendicular_skeleto1.86377641
24MP0001299_abnormal_eye_distance/1.85822320
25MP0001216_abnormal_epidermal_layer1.82588925
26MP0001542_abnormal_bone_strength1.81755980
27MP0000013_abnormal_adipose_tissue1.79995455
28MP0002295_abnormal_pulmonary_circulatio1.79656892
29MP0003385_abnormal_body_wall1.76086824
30MP0002098_abnormal_vibrissa_morphology1.75745300
31MP0005257_abnormal_intraocular_pressure1.74844482
32MP0000733_abnormal_muscle_development1.72707496
33MP0003045_fibrosis1.70083179
34MP0005023_abnormal_wound_healing1.67221417
35MP0004264_abnormal_extraembryonic_tissu1.63095067
36MP0000566_synostosis1.62531140
37MP0010771_integument_phenotype1.60033564
38MP0002108_abnormal_muscle_morphology1.55990592
39MP0002060_abnormal_skin_morphology1.54948161
40MP0010030_abnormal_orbit_morphology1.54759042
41MP0004185_abnormal_adipocyte_glucose1.52296785
42MP0000750_abnormal_muscle_regeneration1.52170649
43MP0000383_abnormal_hair_follicle1.49857036
44MP0000751_myopathy1.48131454
45MP0002896_abnormal_bone_mineralization1.47941403
46MP0010368_abnormal_lymphatic_system1.46579136
47MP0000462_abnormal_digestive_system1.46092026
48MP0000003_abnormal_adipose_tissue1.45927003
49MP0002933_joint_inflammation1.45730075
50MP0000627_abnormal_mammary_gland1.44096524
51MP0005375_adipose_tissue_phenotype1.41787093
52MP0002282_abnormal_trachea_morphology1.38624090
53MP0000767_abnormal_smooth_muscle1.35879127
54MP0001348_abnormal_lacrimal_gland1.35467467
55MP0004233_abnormal_muscle_weight1.31300441
56MP0003315_abnormal_perineum_morphology1.30267093
57MP0005666_abnormal_adipose_tissue1.29966161
58MP0000377_abnormal_hair_follicle1.28322368
59MP0000163_abnormal_cartilage_morphology1.28191884
60MP0001879_abnormal_lymphatic_vessel1.24874551
61MP0005390_skeleton_phenotype1.23588846
62MP0004134_abnormal_chest_morphology1.23489521
63MP0009053_abnormal_anal_canal1.21758617
64MP0000538_abnormal_urinary_bladder1.19017740
65MP0002249_abnormal_larynx_morphology1.16299007
66MP0000749_muscle_degeneration1.13317871
67MP0003303_peritoneal_inflammation1.11832545
68MP0002877_abnormal_melanocyte_morpholog1.11686026
69MP0000678_abnormal_parathyroid_gland1.11206785
70MP0000762_abnormal_tongue_morphology1.09482948
71MP0002168_other_aberrant_phenotype1.07661931
72MP0002115_abnormal_skeleton_extremities1.07327597
73MP0010352_gastrointestinal_tract_polyps1.07254753
74MP0002998_abnormal_bone_remodeling1.06705563
75MP0003755_abnormal_palate_morphology1.05836722
76MP0000534_abnormal_ureter_morphology1.05580233
77MP0000759_abnormal_skeletal_muscle1.03435286
78MP0003942_abnormal_urinary_system1.02687755
79MP0004087_abnormal_muscle_fiber1.01472467
80MP0006054_spinal_hemorrhage1.01188003
81MP0009780_abnormal_chondrocyte_physiolo1.00992439
82MP0005164_abnormal_response_to1.00961431
83MP0005595_abnormal_vascular_smooth0.99631823
84MP0002113_abnormal_skeleton_development0.96984861
85MP0001533_abnormal_skeleton_physiology0.94823653
86MP0001243_abnormal_dermal_layer0.94493153
87MP0003300_gastrointestinal_ulcer0.93418715
88MP0003828_pulmonary_edema0.91214050
89MP0003191_abnormal_cellular_cholesterol0.89671854
90MP0004084_abnormal_cardiac_muscle0.88809879
91MP0005248_abnormal_Harderian_gland0.88330852
92MP0000516_abnormal_urinary_system0.88311343
93MP0005367_renal/urinary_system_phenotyp0.88311343
94MP0003115_abnormal_respiratory_system0.87814581
95MP0002234_abnormal_pharynx_morphology0.87683449
96MP0003941_abnormal_skin_development0.87372118
97MP0006138_congestive_heart_failure0.86733052
98MP0001177_atelectasis0.86372857
99MP0004510_myositis0.85877331
100MP0008004_abnormal_stomach_pH0.85193967
101MP0009931_abnormal_skin_appearance0.83212875
102MP0005670_abnormal_white_adipose0.82338591
103MP0004947_skin_inflammation0.81846324
104MP0002932_abnormal_joint_morphology0.81473414
105MP0005451_abnormal_body_composition0.81274140
106MP0005330_cardiomyopathy0.81156071
107MP0003123_paternal_imprinting0.81004012
108MP0001881_abnormal_mammary_gland0.80818074
109MP0003283_abnormal_digestive_organ0.80713821
110MP0005388_respiratory_system_phenotype0.80466575
111MP0002133_abnormal_respiratory_system0.80466575
112MP0000432_abnormal_head_morphology0.80456914
113MP0001614_abnormal_blood_vessel0.80209095
114MP0002128_abnormal_blood_circulation0.80008894
115MP0002837_dystrophic_cardiac_calcinosis0.79919972
116MP0000428_abnormal_craniofacial_morphol0.79664535
117MP0008260_abnormal_autophagy0.79530442
118MP0000747_muscle_weakness0.79511967
119MP0002116_abnormal_craniofacial_bone0.77939030
120MP0001340_abnormal_eyelid_morphology0.77376060
121MP0000049_abnormal_middle_ear0.76385699
122MP0003448_altered_tumor_morphology0.75754341
123MP0004130_abnormal_muscle_cell0.74848489
124MP0004858_abnormal_nervous_system0.74792793
125MP0000613_abnormal_salivary_gland0.74267694
126MP0009840_abnormal_foam_cell0.74121618
127MP0005620_abnormal_muscle_contractility0.73109573
128MP0005076_abnormal_cell_differentiation0.71877539
129MP0005197_abnormal_uvea_morphology0.70601397
130MP0000343_altered_response_to0.70488272
131MP0002925_abnormal_cardiovascular_devel0.70163152
132MP0005369_muscle_phenotype0.70159605
133MP0002089_abnormal_postnatal_growth/wei0.69542456
134MP0000858_altered_metastatic_potential0.69447238
135MP0003795_abnormal_bone_structure0.69264288
136MP0004883_abnormal_blood_vessel0.69258725
137MP0003935_abnormal_craniofacial_develop0.66477824
138MP0005165_increased_susceptibility_to0.63600440
139MP0010630_abnormal_cardiac_muscle0.62390578
140MP0002697_abnormal_eye_size0.61921896

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)7.69173215
2Protrusio acetabuli (HP:0003179)6.84218749
3Milia (HP:0001056)5.40804868
4Atrophic scars (HP:0001075)4.77265862
5Aortic dissection (HP:0002647)4.63297796
6Shallow orbits (HP:0000586)4.52035413
7Fragile nails (HP:0001808)4.32385247
8Cerebral aneurysm (HP:0004944)4.22811654
9Broad face (HP:0000283)4.21703481
10Onycholysis (HP:0001806)4.03778377
11Aortic aneurysm (HP:0004942)3.81356318
12Soft skin (HP:0000977)3.78081210
13Fragile skin (HP:0001030)3.73015586
14Peritonitis (HP:0002586)3.60205905
15Plantar hyperkeratosis (HP:0007556)3.53589994
16Selective tooth agenesis (HP:0001592)3.40097727
17Dilatation of the ascending aorta (HP:0005111)3.39180914
18Broad metatarsal (HP:0001783)3.33968793
19Increased connective tissue (HP:0009025)3.32236896
20Vascular tortuosity (HP:0004948)3.31498794
21Nail dystrophy (HP:0008404)3.29709439
22Alopecia of scalp (HP:0002293)3.24259922
23Spinal rigidity (HP:0003306)3.22609892
24Mitral valve prolapse (HP:0001634)3.21781226
25Genu recurvatum (HP:0002816)3.18326348
26Bladder diverticulum (HP:0000015)3.10945914
27Arterial tortuosity (HP:0005116)3.07663432
28Neonatal short-limb short stature (HP:0008921)3.06305256
29Hyperacusis (HP:0010780)3.03848050
30Hypoplasia of dental enamel (HP:0006297)3.03815121
31Wormian bones (HP:0002645)3.03660001
32Overgrowth (HP:0001548)3.03150478
33Abnormality of dentin (HP:0010299)3.02271226
34Distal lower limb amyotrophy (HP:0008944)2.98832000
35Ankyloglossia (HP:0010296)2.94569935
36Ankle contracture (HP:0006466)2.88471421
37Blue sclerae (HP:0000592)2.85612470
38Vertebral compression fractures (HP:0002953)2.80135898
39Abnormality of oral frenula (HP:0000190)2.70882956
40Type 1 muscle fiber predominance (HP:0003803)2.68483296
41Thick nail (HP:0001805)2.66845003
42Axonal loss (HP:0003447)2.66365532
43Round ear (HP:0100830)2.65955758
44Hyperextensible skin (HP:0000974)2.64692887
45Abnormality of the distal phalanges of the toes (HP:0010182)2.62982166
46Trismus (HP:0000211)2.62915289
47Cervical subluxation (HP:0003308)2.58193048
48Pili torti (HP:0003777)2.56780693
49Mildly elevated creatine phosphokinase (HP:0008180)2.56237199
50Aplasia cutis congenita (HP:0001057)2.54652014
51Flat acetabular roof (HP:0003180)2.48793016
52Infantile muscular hypotonia (HP:0008947)2.46546262
53Increased variability in muscle fiber diameter (HP:0003557)2.46515290
54Scapular winging (HP:0003691)2.45819144
55Short nail (HP:0001799)2.44025311
56Spinal cord compression (HP:0002176)2.42720159
57Lower limb amyotrophy (HP:0007210)2.41842789
58Abnormality of the distal phalanx of the thumb (HP:0009617)2.41701555
59Hypotrichosis (HP:0001006)2.39986714
60Difficulty climbing stairs (HP:0003551)2.38933903
61Achilles tendon contracture (HP:0001771)2.33514455
62Advanced eruption of teeth (HP:0006288)2.32693301
63Ulnar bowing (HP:0003031)2.31789012
64Ridged nail (HP:0001807)2.31081561
65Bronchomalacia (HP:0002780)2.30001424
66Muscle fiber splitting (HP:0003555)2.29960482
67Natal tooth (HP:0000695)2.29561378
68Follicular hyperkeratosis (HP:0007502)2.28188382
69Vertebral arch anomaly (HP:0008438)2.26270208
70Biconcave vertebral bodies (HP:0004586)2.24622836
71Right ventricular cardiomyopathy (HP:0011663)2.23792205
72Osteolytic defects of the phalanges of the hand (HP:0009771)2.23136566
73Osteolytic defects of the hand bones (HP:0009699)2.23136566
74Venous abnormality (HP:0002624)2.22486087
75Aplasia involving bones of the upper limbs (HP:0009823)2.22243709
76Aplasia of the phalanges of the hand (HP:0009802)2.22243709
77Aplasia involving bones of the extremities (HP:0009825)2.22243709
78Abnormal ossification of hand bones (HP:0005921)2.22089041
79Abnormal delivery (HP:0001787)2.21548542
80Wide anterior fontanel (HP:0000260)2.21129778
81Aneurysm (HP:0002617)2.20709999
82Abnormality of the gastric mucosa (HP:0004295)2.20037773
83Coronal craniosynostosis (HP:0004440)2.18678210
84Focal segmental glomerulosclerosis (HP:0000097)2.17525619
85Mitral regurgitation (HP:0001653)2.17160330
86Elbow flexion contracture (HP:0002987)2.16717485
87Abnormality of carpal bone ossification (HP:0006257)2.16485831
88Abnormality of skeletal muscle fiber size (HP:0012084)2.16249860
89Wrist flexion contracture (HP:0001239)2.12835473
90Buphthalmos (HP:0000557)2.09464786
91Broad ribs (HP:0000885)2.09360289
92Abnormality of nail color (HP:0100643)2.09357039
93Abnormality of the acetabulum (HP:0003170)2.04197200
94Increased density of long bones (HP:0006392)2.03631756
95Deviation of the hallux (HP:0010051)2.02768255
96Abnormal blistering of the skin (HP:0008066)2.02725805
97Elfin facies (HP:0004428)2.02042311
98Aortic regurgitation (HP:0001659)2.00834676
99Osteoarthritis (HP:0002758)2.00583776
100Joint laxity (HP:0001388)1.99834238
101Camptodactyly of toe (HP:0001836)1.95541037
102Spondylolisthesis (HP:0003302)1.94550321
103Coxa vara (HP:0002812)1.92992047
104Abnormality of the Achilles tendon (HP:0005109)1.92518852
105Palmoplantar hyperkeratosis (HP:0000972)1.92253591
106Popliteal pterygium (HP:0009756)1.92028329
107Hallux valgus (HP:0001822)1.91896145
108Hypoplastic ischia (HP:0003175)1.91078534
109Venous insufficiency (HP:0005293)1.90697114
110Difficulty running (HP:0009046)1.88987566
111Vascular calcification (HP:0004934)1.88982723
112Abnormal hair laboratory examination (HP:0003328)1.88507272
113Bowel diverticulosis (HP:0005222)1.87432495
114Disproportionate tall stature (HP:0001519)1.87352224
115Hip contracture (HP:0003273)1.87250547
116Amelogenesis imperfecta (HP:0000705)1.87119992
117Abnormal vertebral ossification (HP:0100569)1.86642672
118Hypoplasia of the iris (HP:0007676)1.86072504
119Slender build (HP:0001533)1.85160140
120J-shaped sella turcica (HP:0002680)1.84868768
121Hyporeflexia of lower limbs (HP:0002600)1.84506479
122Sparse eyelashes (HP:0000653)1.83108686
123Congenital glaucoma (HP:0001087)1.82800138
124Bowed forearm bones (HP:0003956)1.81785296
125Bowing of the arm (HP:0006488)1.81785296
126Flattened epiphyses (HP:0003071)1.81212279
127Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.80987520
128Ventricular tachycardia (HP:0004756)1.80502994
129Abnormality of the calf musculature (HP:0001430)1.79761835
130Upper limb amyotrophy (HP:0009129)1.79577345
131Distal upper limb amyotrophy (HP:0007149)1.79577345
132Micronodular cirrhosis (HP:0001413)1.79564167
133Ureteral stenosis (HP:0000071)1.79293561
134Glomerulosclerosis (HP:0000096)1.78338339
135Epiphyseal dysplasia (HP:0002656)1.77448635
136Ectopia lentis (HP:0001083)1.77212310
137Neonatal death (HP:0003811)1.76858110
138Pterygium (HP:0001059)1.76828467
139Back pain (HP:0003418)1.76657097
140Arnold-Chiari malformation (HP:0002308)1.76642273
141Vertebral clefting (HP:0008428)1.76442234
142Striae distensae (HP:0001065)1.75241361
143Palmar hyperkeratosis (HP:0010765)1.74662559
144Vertebral hypoplasia (HP:0008417)1.74235437
145Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.74235437
146Nuclear cataract (HP:0100018)1.72652615
147Abnormal hand bone ossification (HP:0010660)1.71623318
148Distal lower limb muscle weakness (HP:0009053)1.71005522
149Short hallux (HP:0010109)1.70757370
150Growth hormone excess (HP:0000845)1.70637001
151Reduced subcutaneous adipose tissue (HP:0003758)1.70606441
152Tibial bowing (HP:0002982)1.70202265
153Cardiovascular calcification (HP:0011915)1.69620452
154Hyperparathyroidism (HP:0000843)1.68965624
155Limited hip movement (HP:0008800)1.68548973
156Obstructive sleep apnea (HP:0002870)1.67272357
157Osteopenia (HP:0000938)1.65533455
158Thin bony cortex (HP:0002753)1.65229999
159Interstitial pulmonary disease (HP:0006530)1.64575315
160Thin ribs (HP:0000883)1.64338995
161Acanthosis nigricans (HP:0000956)1.63919266
162Joint stiffness (HP:0001387)1.63912725
163Abnormality of the peritoneum (HP:0002585)1.62498842

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.39486814
2LMTK24.02648168
3TRIB33.89181066
4DDR23.49024304
5IRAK32.95279703
6EPHB22.78989400
7FER2.70767513
8TTN2.66238277
9EPHB12.64659426
10EPHA22.44639846
11PDGFRA2.38034140
12DMPK2.25687697
13NME22.22633761
14PIM22.19674801
15TGFBR22.08982575
16LATS21.99726970
17LATS11.92128874
18PTK2B1.87890930
19BMX1.74813944
20PAK21.71090235
21SIK11.69274294
22ARAF1.68775163
23EPHA31.68673070
24PTK21.68219365
25PAK31.56489922
26PIK3CA1.48295842
27CAMK1G1.46924260
28PAK41.45800916
29RIPK11.42581181
30STK391.31381641
31NTRK11.29065668
32PKN21.28666804
33LIMK11.27754669
34MAP3K91.26363294
35MOS1.25967671
36CAMK1D1.20855422
37PDGFRB1.18617976
38ROCK11.10746601
39TRPM71.10070055
40TYRO31.10027970
41TAOK11.09912562
42DAPK31.09352040
43MYLK1.07389491
44SMG11.06233859
45ROCK21.06161029
46ERN11.00863120
47FES1.00831209
48MET1.00081676
49MAP2K10.97416195
50SIK30.96773732
51STK380.95442130
52ILK0.93834268
53INSR0.91159580
54MAP3K120.89975802
55MAPKAPK30.89666357
56ERBB40.88467895
57PTK60.88456408
58PHKG20.87905963
59PHKG10.87905963
60PRKD10.86044460
61RET0.85390656
62PRKD20.84734520
63CDK140.83400134
64WNK40.82522682
65CDK80.81958226
66NEK90.80121132
67LRRK20.79183020
68RPS6KB20.78964406
69SCYL20.78610608
70PRKD30.77202363
71PLK20.76482083
72CSK0.76341025
73MARK20.74524164
74WNK10.73198443
75TESK10.69971189
76EPHA40.68531973
77CAMK2D0.65715169
78FGR0.65362810
79CAMK2G0.64823519
80PRKG20.63831360
81MAP3K20.63081273
82FGFR10.61652611
83KSR10.61485130
84PRKCE0.61228615
85PRKCI0.60908866
86CDK60.60832995
87CHUK0.60330268
88MAP3K30.58315858
89CDK150.58291737
90DYRK1B0.58184217
91NTRK30.57732832
92CDC42BPA0.57167963
93RPS6KA20.55077976
94PAK60.54341219
95STK38L0.54127607
96SRC0.52567267
97CDK180.52281399
98MTOR0.51269359
99GSK3A0.51240533
100FYN0.51219101
101CASK0.50233651
102CAMK2B0.50069695
103CDK11A0.49709012
104STK110.49016232
105ADRBK10.47194443
106NEK60.46183870
107PRKCH0.46030687
108MINK10.45827996
109CAMK2A0.45454661
110NUAK10.45121980
111MAPKAPK50.44745758
112IRAK10.44255297
113MELK0.44014997
114NLK0.43904533
115MAP2K20.43863035
116HIPK20.43511501
117PRPF4B0.43282435
118FGFR40.42505011
119CDK120.41693660
120ICK0.41196087
121STK30.40775421
122STK240.40076042
123CDK90.37934028
124ABL20.36636956
125IRAK20.36630671
126PDPK10.36234199
127MAPK120.36146773
128PDK20.36019492
129CDK50.35821917
130MUSK0.35437558
131TESK20.34373591
132MAPKAPK20.32528873
133MAP3K10.29450729
134EEF2K0.27876136
135DAPK10.27561564
136MAP3K70.27324119
137MAP3K60.26437878
138PAK10.24213820
139BRAF0.23047538
140CDK70.22223040
141MAP3K80.20916724
142ERBB20.20686796

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.15013653
2Focal adhesion_Homo sapiens_hsa045102.33101046
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.14040813
4Dilated cardiomyopathy_Homo sapiens_hsa054142.02199427
5Notch signaling pathway_Homo sapiens_hsa043302.01895474
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.89734070
7Proteoglycans in cancer_Homo sapiens_hsa052051.79504052
8AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.78406796
9Adherens junction_Homo sapiens_hsa045201.66730202
10Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.66558901
11Amoebiasis_Homo sapiens_hsa051461.61697896
12Bladder cancer_Homo sapiens_hsa052191.60027441
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.54383579
14Axon guidance_Homo sapiens_hsa043601.50894106
15TGF-beta signaling pathway_Homo sapiens_hsa043501.49404642
16Malaria_Homo sapiens_hsa051441.45043713
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.42477060
18Renal cell carcinoma_Homo sapiens_hsa052111.41458620
19Hippo signaling pathway_Homo sapiens_hsa043901.38246405
20Protein digestion and absorption_Homo sapiens_hsa049741.35963528
21Regulation of actin cytoskeleton_Homo sapiens_hsa048101.34725077
22Glioma_Homo sapiens_hsa052141.29825866
23Chronic myeloid leukemia_Homo sapiens_hsa052201.28142675
24Small cell lung cancer_Homo sapiens_hsa052221.24663836
25Melanoma_Homo sapiens_hsa052181.23594764
26PI3K-Akt signaling pathway_Homo sapiens_hsa041511.21775824
27Tight junction_Homo sapiens_hsa045301.17741233
28Rap1 signaling pathway_Homo sapiens_hsa040151.14428211
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14338175
30Gap junction_Homo sapiens_hsa045401.13209058
31Galactose metabolism_Homo sapiens_hsa000521.12783505
32Central carbon metabolism in cancer_Homo sapiens_hsa052301.10787030
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.10686980
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.09799565
35Vitamin B6 metabolism_Homo sapiens_hsa007501.09435284
36MicroRNAs in cancer_Homo sapiens_hsa052061.09167754
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08733358
38Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08625262
39Melanogenesis_Homo sapiens_hsa049161.06424199
40Viral myocarditis_Homo sapiens_hsa054161.05674369
41Fructose and mannose metabolism_Homo sapiens_hsa000511.05667799
42Cocaine addiction_Homo sapiens_hsa050301.04740623
43GnRH signaling pathway_Homo sapiens_hsa049121.04608107
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.04217082
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04185790
46Pancreatic cancer_Homo sapiens_hsa052121.02902371
47Platelet activation_Homo sapiens_hsa046111.01836258
48Estrogen signaling pathway_Homo sapiens_hsa049151.01133347
49Glycosaminoglycan degradation_Homo sapiens_hsa005311.00953605
50Fatty acid biosynthesis_Homo sapiens_hsa000611.00863524
51ErbB signaling pathway_Homo sapiens_hsa040121.00005097
52Oxytocin signaling pathway_Homo sapiens_hsa049210.98926992
53Basal cell carcinoma_Homo sapiens_hsa052170.98656394
54Wnt signaling pathway_Homo sapiens_hsa043100.98440383
55Hedgehog signaling pathway_Homo sapiens_hsa043400.98183014
56AMPK signaling pathway_Homo sapiens_hsa041520.97526249
57Insulin signaling pathway_Homo sapiens_hsa049100.97388777
58Long-term depression_Homo sapiens_hsa047300.96590959
59Phenylalanine metabolism_Homo sapiens_hsa003600.94899737
60VEGF signaling pathway_Homo sapiens_hsa043700.94561520
61Prostate cancer_Homo sapiens_hsa052150.93609751
62Ras signaling pathway_Homo sapiens_hsa040140.92961397
63Renin secretion_Homo sapiens_hsa049240.92045684
64Hepatitis C_Homo sapiens_hsa051600.91476220
65Shigellosis_Homo sapiens_hsa051310.90729519
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90345997
67Cholinergic synapse_Homo sapiens_hsa047250.89732391
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.89414722
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88333702
70Toxoplasmosis_Homo sapiens_hsa051450.88211311
71Pathways in cancer_Homo sapiens_hsa052000.87999442
72Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87342210
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.87133756
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.84402598
75Endocytosis_Homo sapiens_hsa041440.83138346
76Salivary secretion_Homo sapiens_hsa049700.82637399
77Bile secretion_Homo sapiens_hsa049760.82608421
78Salmonella infection_Homo sapiens_hsa051320.81400432
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80485614
80TNF signaling pathway_Homo sapiens_hsa046680.79113818
81Dorso-ventral axis formation_Homo sapiens_hsa043200.78985047
82HIF-1 signaling pathway_Homo sapiens_hsa040660.78758783
83Non-small cell lung cancer_Homo sapiens_hsa052230.78530177
84MAPK signaling pathway_Homo sapiens_hsa040100.78423400
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78189690
86Dopaminergic synapse_Homo sapiens_hsa047280.76572073
87Osteoclast differentiation_Homo sapiens_hsa043800.76312573
88Gastric acid secretion_Homo sapiens_hsa049710.75851925
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75467835
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75187330
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.74485202
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73922791
93Rheumatoid arthritis_Homo sapiens_hsa053230.71603168
94N-Glycan biosynthesis_Homo sapiens_hsa005100.70970713
95cAMP signaling pathway_Homo sapiens_hsa040240.70528459
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70169827
97Insulin resistance_Homo sapiens_hsa049310.69179986
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69085427
99Phagosome_Homo sapiens_hsa041450.68960543
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68251821
101Acute myeloid leukemia_Homo sapiens_hsa052210.67219093
102Amphetamine addiction_Homo sapiens_hsa050310.66073186
103Vibrio cholerae infection_Homo sapiens_hsa051100.65888219
104Long-term potentiation_Homo sapiens_hsa047200.65592622
105Prion diseases_Homo sapiens_hsa050200.64205738
106Circadian entrainment_Homo sapiens_hsa047130.63818739
107Endometrial cancer_Homo sapiens_hsa052130.63156590
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.62570037
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62056402
110Serotonergic synapse_Homo sapiens_hsa047260.61935143
111Colorectal cancer_Homo sapiens_hsa052100.60199308
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58834783
113Pentose phosphate pathway_Homo sapiens_hsa000300.58327125
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.58023996
115mTOR signaling pathway_Homo sapiens_hsa041500.56566817
116Choline metabolism in cancer_Homo sapiens_hsa052310.54333150
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54085182
118Thyroid cancer_Homo sapiens_hsa052160.53539728
119PPAR signaling pathway_Homo sapiens_hsa033200.53151578
120Circadian rhythm_Homo sapiens_hsa047100.52625643
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52093909
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51761939
123HTLV-I infection_Homo sapiens_hsa051660.51315921
124Sulfur relay system_Homo sapiens_hsa041220.50165792
125Steroid biosynthesis_Homo sapiens_hsa001000.47487091
126Glucagon signaling pathway_Homo sapiens_hsa049220.46149563
127Pancreatic secretion_Homo sapiens_hsa049720.45781941
128Apoptosis_Homo sapiens_hsa042100.45300738
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44104805
130Other glycan degradation_Homo sapiens_hsa005110.43471182
131Glycerolipid metabolism_Homo sapiens_hsa005610.42906975
132Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41639412
133Lysosome_Homo sapiens_hsa041420.41487996

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