PMF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)8.90025462
2daunorubicin metabolic process (GO:0044597)8.90025462
3polyketide metabolic process (GO:0030638)8.90025462
4protein localization to kinetochore (GO:0034501)6.46160730
5regulation of nuclear cell cycle DNA replication (GO:0033262)6.10123706
6aminoglycoside antibiotic metabolic process (GO:0030647)5.66922524
7negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.47720418
8mitotic sister chromatid segregation (GO:0000070)5.40657533
9regulation of mammary gland epithelial cell proliferation (GO:0033599)5.37692951
10regulation of telomere maintenance via telomerase (GO:0032210)5.33206139
11protein localization to chromosome, centromeric region (GO:0071459)5.32023160
12negative regulation of telomerase activity (GO:0051974)5.15561132
13negative regulation of epidermis development (GO:0045683)5.14287589
14negative regulation of cell cycle G2/M phase transition (GO:1902750)5.12090582
15maintenance of protein location in nucleus (GO:0051457)5.09042587
16DNA deamination (GO:0045006)5.07230415
17DNA replication checkpoint (GO:0000076)5.05549224
18somite rostral/caudal axis specification (GO:0032525)5.03089477
19rRNA transcription (GO:0009303)4.92731880
20histone H4-K12 acetylation (GO:0043983)4.70823779
21regulation of response to osmotic stress (GO:0047484)4.69222543
22DNA replication-dependent nucleosome assembly (GO:0006335)4.62843167
23DNA replication-dependent nucleosome organization (GO:0034723)4.62843167
24sister chromatid segregation (GO:0000819)4.57203646
25histone H4-K8 acetylation (GO:0043982)4.56464832
26histone H4-K5 acetylation (GO:0043981)4.56464832
27negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.54877163
28positive regulation of DNA-dependent DNA replication (GO:2000105)4.53719376
29regulation of mitochondrial translation (GO:0070129)4.51642334
30rRNA methylation (GO:0031167)4.50591482
31rRNA modification (GO:0000154)4.46853555
32deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.30734511
33heterochromatin organization (GO:0070828)4.28493913
34negative regulation of telomere maintenance (GO:0032205)4.23273237
35nuclear pore complex assembly (GO:0051292)4.21120747
36negative regulation of epidermal cell differentiation (GO:0045605)4.20229462
37negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.17660146
38mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.15901919
39regulation of MHC class I biosynthetic process (GO:0045343)4.11370928
40chaperone-mediated protein transport (GO:0072321)4.10206542
41muscle organ morphogenesis (GO:0048644)4.09945649
42ribosomal small subunit assembly (GO:0000028)4.02013652
43notochord development (GO:0030903)3.98905990
44nuclear pore organization (GO:0006999)3.98638072
45proteasome assembly (GO:0043248)3.95886505
46protein complex biogenesis (GO:0070271)3.95506851
47metallo-sulfur cluster assembly (GO:0031163)3.94769175
48iron-sulfur cluster assembly (GO:0016226)3.94769175
49pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.94648652
50establishment of protein localization to mitochondrial membrane (GO:0090151)3.93732369
51regulation of translation in response to stress (GO:0043555)3.84853214
52DNA replication initiation (GO:0006270)3.84394170
53regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.82799092
54ribosome biogenesis (GO:0042254)3.82395438
55positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.82210964
56energy coupled proton transport, down electrochemical gradient (GO:0015985)3.81661803
57ATP synthesis coupled proton transport (GO:0015986)3.81661803
58negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.81424080
59negative regulation of ligase activity (GO:0051352)3.81424080
60regulation of cellular amino acid metabolic process (GO:0006521)3.80470159
61cytidine deamination (GO:0009972)3.80155527
62cytidine metabolic process (GO:0046087)3.80155527
63cytidine catabolic process (GO:0006216)3.80155527
64DNA unwinding involved in DNA replication (GO:0006268)3.79704931
65chromatin assembly (GO:0031497)3.79514775
66mitochondrial respiratory chain complex assembly (GO:0033108)3.75350279
67mitotic chromosome condensation (GO:0007076)3.72097727
68formation of translation preinitiation complex (GO:0001731)3.68215464
69mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.64469257
70mitochondrial respiratory chain complex I assembly (GO:0032981)3.64469257
71NADH dehydrogenase complex assembly (GO:0010257)3.64469257
72DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.64083676
73RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.61315415
74tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.61315415
75regulation of apoptotic process involved in morphogenesis (GO:1902337)3.59493565
76DNA duplex unwinding (GO:0032508)3.57824457
77anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.57187771
78signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.56278544
79signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.56278544
80signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.56278544
81intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.54933182
82signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.54933182
83cullin deneddylation (GO:0010388)3.54045681
84DNA geometric change (GO:0032392)3.53821209
85interferon-gamma production (GO:0032609)3.52935950
86pseudouridine synthesis (GO:0001522)3.52817375
87quinone metabolic process (GO:1901661)3.52513391
88mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.50303059
89regulation of cilium movement (GO:0003352)3.49149360
90DNA damage response, detection of DNA damage (GO:0042769)3.45449916
91signal transduction involved in DNA damage checkpoint (GO:0072422)3.43695374
92signal transduction involved in DNA integrity checkpoint (GO:0072401)3.43695374
93pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.42653981
94primitive streak formation (GO:0090009)3.42560900
95respiratory electron transport chain (GO:0022904)3.41235479
96ribosomal small subunit biogenesis (GO:0042274)3.38704980
97signal transduction involved in cell cycle checkpoint (GO:0072395)3.38007015
98nucleoside transmembrane transport (GO:1901642)3.37857380
99deoxyribonucleotide catabolic process (GO:0009264)3.36528129
100electron transport chain (GO:0022900)3.34403175
101histone H4-K16 acetylation (GO:0043984)3.31876868
102regulation of telomerase activity (GO:0051972)3.30514282
103pyrimidine nucleotide catabolic process (GO:0006244)3.30470636
104base-excision repair, AP site formation (GO:0006285)3.29228403
105oxidative phosphorylation (GO:0006119)3.28050258
106deoxyribose phosphate catabolic process (GO:0046386)3.27302580
107positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.27000143
108deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.26649195
109pore complex assembly (GO:0046931)3.25552615
110protein deneddylation (GO:0000338)3.22492693
111regulation of DNA-dependent DNA replication (GO:0090329)3.22022588
112RNA stabilization (GO:0043489)3.20488002
113mRNA stabilization (GO:0048255)3.20488002
114DNA strand elongation involved in DNA replication (GO:0006271)3.19453572
115cytochrome complex assembly (GO:0017004)3.19190208
116regulation of double-strand break repair (GO:2000779)3.18471341
117ribonucleoprotein complex biogenesis (GO:0022613)3.18124398
118mitotic G2/M transition checkpoint (GO:0044818)3.17699633
119protein targeting to mitochondrion (GO:0006626)3.17577818
120regulation of telomere maintenance (GO:0032204)3.17550110
121positive regulation of ligase activity (GO:0051351)3.17265983
122pyrimidine ribonucleoside catabolic process (GO:0046133)3.16202121
123nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.16083000
124branching involved in mammary gland duct morphogenesis (GO:0060444)3.14848295
125antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.11869010
126attachment of spindle microtubules to kinetochore (GO:0008608)3.11749037
127cell fate commitment involved in formation of primary germ layer (GO:0060795)3.11486402
128termination of RNA polymerase III transcription (GO:0006386)3.11046389
129transcription elongation from RNA polymerase III promoter (GO:0006385)3.11046389
130peptidyl-histidine modification (GO:0018202)3.10360549
131telomere maintenance via semi-conservative replication (GO:0032201)3.08069406
132regulation of double-strand break repair via homologous recombination (GO:0010569)3.06602743
133phenol-containing compound catabolic process (GO:0019336)3.04788638
134purine deoxyribonucleotide catabolic process (GO:0009155)3.04231221
135hormone catabolic process (GO:0042447)3.02783436
136DNA strand elongation (GO:0022616)3.02743292
137exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.02356628
138establishment of integrated proviral latency (GO:0075713)3.00866176
139establishment of protein localization to mitochondrion (GO:0072655)3.00069549
140mitochondrial DNA replication (GO:0006264)2.99220126
141regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.98196283
142kinetochore assembly (GO:0051382)2.98008100
143regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.97728051
144mitotic metaphase plate congression (GO:0007080)2.97622182
145transcription from mitochondrial promoter (GO:0006390)2.96801352
146spliceosomal snRNP assembly (GO:0000387)2.96615675
147intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.96497651
148regulation of posttranscriptional gene silencing (GO:0060147)2.95505053
149regulation of gene silencing by miRNA (GO:0060964)2.95505053
150regulation of gene silencing by RNA (GO:0060966)2.95505053
151GDP-mannose metabolic process (GO:0019673)2.95228631
152pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.94104437
153regulation of ubiquitin-protein transferase activity (GO:0051438)2.93604721
154DNA conformation change (GO:0071103)2.91974698
155apoptotic DNA fragmentation (GO:0006309)2.91462360
156maturation of SSU-rRNA (GO:0030490)2.91198547
157respiratory chain complex IV assembly (GO:0008535)2.91147131
158peptidyl-arginine omega-N-methylation (GO:0035247)2.89812930
159protein localization to chromosome (GO:0034502)2.89583805
160maturation of 5.8S rRNA (GO:0000460)2.89355728
161antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.88464679
162pre-miRNA processing (GO:0031054)2.87917439
163regulation of ligase activity (GO:0051340)2.86886670
164mitotic nuclear envelope disassembly (GO:0007077)2.86662944
165positive regulation of cell cycle arrest (GO:0071158)2.86479599
166inner mitochondrial membrane organization (GO:0007007)2.86099762
167chromatin assembly or disassembly (GO:0006333)2.85769540
168ubiquinone biosynthetic process (GO:0006744)2.84795892
169chromatin remodeling at centromere (GO:0031055)2.84680888
170DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.83438493
171DNA ligation (GO:0006266)2.83417889
172bone trabecula formation (GO:0060346)2.82655756
173translation (GO:0006412)2.82316291
174pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.82033345
175spindle assembly (GO:0051225)2.81199712
176protein localization to mitochondrion (GO:0070585)2.80142486
177CENP-A containing nucleosome assembly (GO:0034080)2.79626230
178response to dietary excess (GO:0002021)2.79300504
1792-deoxyribonucleotide metabolic process (GO:0009394)2.79266354
180mitotic recombination (GO:0006312)2.77906023
181positive regulation of protein deacetylation (GO:0090312)2.76844664
182regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.76756620
183histone arginine methylation (GO:0034969)2.76648523
184negative regulation by host of viral transcription (GO:0043922)2.75256081
185viral mRNA export from host cell nucleus (GO:0046784)2.75155306
186regulation of cellular amine metabolic process (GO:0033238)2.74319113
187negative regulation of B cell apoptotic process (GO:0002903)2.73040648
188cellular component biogenesis (GO:0044085)2.72729955
189deoxyribose phosphate metabolic process (GO:0019692)2.71683971

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.33152548
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.92384549
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.76084262
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.76084262
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.76084262
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.07117485
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.51926776
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.38306437
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.25304816
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.95131135
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.89468415
12* MYC_18555785_ChIP-Seq_MESCs_Mouse2.87132995
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.44591418
14SRF_21415370_ChIP-Seq_HL-1_Mouse2.41483884
15NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.41422116
16SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.40590554
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.40189538
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.38183652
19POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.35669897
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.25891715
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.20613957
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.18317909
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.08181204
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.06317894
25* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.05483460
26SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.03606978
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.98688961
28TCF3_18692474_ChIP-Seq_MEFs_Mouse1.95565185
29HOXB4_20404135_ChIP-ChIP_EML_Mouse1.93283209
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.92672789
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.92141698
32TCF3_18692474_ChIP-Seq_MESCs_Mouse1.91392029
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.91250116
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.86952609
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.84995038
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.84342517
37NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.78336763
38NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.73801229
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.72740399
40IRF1_19129219_ChIP-ChIP_H3396_Human1.71993077
41CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.71188351
42* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.69206378
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.69125553
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.67585036
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63632526
46* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.62746924
47CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.59866157
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.59777349
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.58343653
50KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.57791686
51RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53710390
52ETS1_20019798_ChIP-Seq_JURKAT_Human1.53639566
53* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.52397358
54SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.51883548
55BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.50295371
56GABP_17652178_ChIP-ChIP_JURKAT_Human1.48758485
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.47098326
58FOXP3_21729870_ChIP-Seq_TREG_Human1.46980750
59SOX2_18555785_ChIP-Seq_MESCs_Mouse1.42610983
60* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41572181
61NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.39977088
62NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.38894491
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37816252
64* XRN2_22483619_ChIP-Seq_HELA_Human1.34158804
65* MYC_22102868_ChIP-Seq_BL_Human1.33133075
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.33052718
67AR_21909140_ChIP-Seq_LNCAP_Human1.32699109
68MYC_18940864_ChIP-ChIP_HL60_Human1.32085746
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30230214
70* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.29170427
71HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.26017809
72POU5F1_16518401_ChIP-PET_MESCs_Mouse1.25870393
73POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.21742833
74KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.20350092
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20064265
76PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.19469544
77VDR_23849224_ChIP-Seq_CD4+_Human1.18995588
78OCT4_18692474_ChIP-Seq_MEFs_Mouse1.17712603
79HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16707392
80NANOG_18692474_ChIP-Seq_MEFs_Mouse1.15488862
81TTF2_22483619_ChIP-Seq_HELA_Human1.14286343
82* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13176784
83ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.12355707
84ELF1_17652178_ChIP-ChIP_JURKAT_Human1.10409851
85SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10347042
86MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10128353
87E2F1_21310950_ChIP-Seq_MCF-7_Human1.10102885
88SOX2_18692474_ChIP-Seq_MEFs_Mouse1.09628689
89EGR1_19374776_ChIP-ChIP_THP-1_Human1.09058615
90TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.08735288
91CIITA_25753668_ChIP-Seq_RAJI_Human1.08358066
92HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07681093
93NANOG_18692474_ChIP-Seq_MESCs_Mouse1.07657213
94* GABP_19822575_ChIP-Seq_HepG2_Human1.07341075
95SOX2_18692474_ChIP-Seq_MESCs_Mouse1.06738938
96IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.06538384
97KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06268038
98E2F1_17053090_ChIP-ChIP_MCF-7_Human1.03730122
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03107879
100PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01970402
101NANOG_16153702_ChIP-ChIP_HESCs_Human1.01353412
102CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99697110
103NANOG_21062744_ChIP-ChIP_HESCs_Human0.99134743
104DCP1A_22483619_ChIP-Seq_HELA_Human0.98929483
105TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98783343
106PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98393843
107* FOXP1_21924763_ChIP-Seq_HESCs_Human0.97931098
108THAP11_20581084_ChIP-Seq_MESCs_Mouse0.96031744
109BCL6_27268052_Chip-Seq_Bcells_Human0.95565413
110KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95107401
111* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95046078
112* KDM5A_27292631_Chip-Seq_BREAST_Human0.94954186
113SPI1_23547873_ChIP-Seq_NB4_Human0.94839714
114ELF1_20517297_ChIP-Seq_JURKAT_Human0.93074577
115CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91366376
116DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91039113
117* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90752479
118SCL_19346495_ChIP-Seq_HPC-7_Human0.90303126
119MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.89473216
120SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.89471070
121IRF8_22096565_ChIP-ChIP_GC-B_Human0.89189207
122FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88883598
123* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88726406
124RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.87189912
125PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.87184912
126CTCF_26484167_Chip-Seq_Bcells_Mouse0.87157690
127ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86993838
128EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.86729423
129* MAF_26560356_Chip-Seq_TH2_Human0.85585237
130ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84703631
131RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.83805146
132* MYB_26560356_Chip-Seq_TH2_Human0.83565920
133CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82563640
134STAT4_19710469_ChIP-ChIP_TH1__Mouse0.82065985
135ELK1_19687146_ChIP-ChIP_HELA_Human0.81973814
136TET1_21451524_ChIP-Seq_MESCs_Mouse0.80844446
137YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.80338444
138HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.78774813
139BCOR_27268052_Chip-Seq_Bcells_Human0.77978026
140POU5F1_16153702_ChIP-ChIP_HESCs_Human0.76904066
141YY1_22570637_ChIP-Seq_MALME-3M_Human0.75678723
142* NANOG_16518401_ChIP-PET_MESCs_Mouse0.75552107
143TFEB_21752829_ChIP-Seq_HELA_Human0.74846804
144* NCOR1_26117541_ChIP-Seq_K562_Human0.74459664
145SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.73804584

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.27539843
2MP0003011_delayed_dark_adaptation4.01624228
3MP0008057_abnormal_DNA_replication3.89433199
4MP0004264_abnormal_extraembryonic_tissu3.75927303
5MP0003806_abnormal_nucleotide_metabolis3.70232678
6MP0004957_abnormal_blastocyst_morpholog3.65357973
7MP0000372_irregular_coat_pigmentation3.27556705
8MP0002254_reproductive_system_inflammat3.18710544
9MP0005075_abnormal_melanosome_morpholog3.08320324
10MP0003890_abnormal_embryonic-extraembry3.00469305
11MP0005499_abnormal_olfactory_system2.82576420
12MP0005394_taste/olfaction_phenotype2.82576420
13MP0003077_abnormal_cell_cycle2.61793500
14MP0003111_abnormal_nucleus_morphology2.60678612
15MP0010094_abnormal_chromosome_stability2.59077699
16MP0003693_abnormal_embryo_hatching2.46476847
17MP0009333_abnormal_splenocyte_physiolog2.40641572
18MP0005671_abnormal_response_to2.37452307
19MP0003121_genomic_imprinting2.27318634
20MP0004147_increased_porphyrin_level2.26773969
21MP0003122_maternal_imprinting2.21681541
22MP0003646_muscle_fatigue2.19710926
23MP0010352_gastrointestinal_tract_polyps2.03626883
24MP0002396_abnormal_hematopoietic_system2.02640508
25MP0006035_abnormal_mitochondrial_morpho1.99546563
26MP0002332_abnormal_exercise_endurance1.97577716
27MP0001672_abnormal_embryogenesis/_devel1.96786201
28MP0005380_embryogenesis_phenotype1.96786201
29MP0004858_abnormal_nervous_system1.91854822
30MP0005257_abnormal_intraocular_pressure1.91101288
31MP0002163_abnormal_gland_morphology1.85355237
32MP0000350_abnormal_cell_proliferation1.84091429
33MP0002148_abnormal_hypersensitivity_rea1.82990573
34MP0000678_abnormal_parathyroid_gland1.82286679
35MP0002653_abnormal_ependyma_morphology1.80156654
36MP0003984_embryonic_growth_retardation1.78390872
37MP0002088_abnormal_embryonic_growth/wei1.78157179
38MP0003123_paternal_imprinting1.73239185
39MP0008007_abnormal_cellular_replicative1.70096986
40MP0003763_abnormal_thymus_physiology1.68688373
41MP0010030_abnormal_orbit_morphology1.62772945
42MP0008932_abnormal_embryonic_tissue1.62656253
43MP0001293_anophthalmia1.60373410
44MP0002277_abnormal_respiratory_mucosa1.58661977
45MP0003938_abnormal_ear_development1.58266527
46MP0001764_abnormal_homeostasis1.57753321
47MP0005084_abnormal_gallbladder_morpholo1.57030602
48MP0003705_abnormal_hypodermis_morpholog1.53683278
49MP0008058_abnormal_DNA_repair1.52127228
50MP0000490_abnormal_crypts_of1.49800992
51MP0008877_abnormal_DNA_methylation1.47402743
52MP0008995_early_reproductive_senescence1.46827526
53MP0003718_maternal_effect1.44303420
54MP0003315_abnormal_perineum_morphology1.43163772
55MP0008789_abnormal_olfactory_epithelium1.41364367
56MP0002085_abnormal_embryonic_tissue1.39251678
57MP0002127_abnormal_cardiovascular_syste1.38573073
58MP0002086_abnormal_extraembryonic_tissu1.35411233
59MP0000049_abnormal_middle_ear1.35179564
60MP0003786_premature_aging1.33913226
61MP0002398_abnormal_bone_marrow1.31920735
62MP0000313_abnormal_cell_death1.31241092
63MP0001730_embryonic_growth_arrest1.30356877
64MP0001835_abnormal_antigen_presentation1.28902824
65MP0002092_abnormal_eye_morphology1.27408589
66MP0001661_extended_life_span1.27378289
67MP0003567_abnormal_fetal_cardiomyocyte1.25475362
68MP0001873_stomach_inflammation1.25232988
69MP0002723_abnormal_immune_serum1.25030755
70MP0002932_abnormal_joint_morphology1.23423230
71MP0002132_abnormal_respiratory_system1.20410719
72MP0009697_abnormal_copulation1.19093907
73MP0004133_heterotaxia1.18918445
74MP0002420_abnormal_adaptive_immunity1.16815984
75MP0000762_abnormal_tongue_morphology1.15974529
76MP0001819_abnormal_immune_cell1.15736254
77MP0001919_abnormal_reproductive_system1.15369956
78MP0005000_abnormal_immune_tolerance1.15333449
79MP0001800_abnormal_humoral_immune1.13499289
80MP0001697_abnormal_embryo_size1.12849242
81MP0009785_altered_susceptibility_to1.12166755
82MP0005266_abnormal_metabolism1.12132801
83MP0002084_abnormal_developmental_patter1.11813993
84MP0001849_ear_inflammation1.11607339
85MP0006082_CNS_inflammation1.10376699
86MP0001727_abnormal_embryo_implantation1.09632854
87MP0004197_abnormal_fetal_growth/weight/1.09597969
88MP0005379_endocrine/exocrine_gland_phen1.08997626
89MP0000716_abnormal_immune_system1.08030198
90MP0005330_cardiomyopathy1.07772954
91MP0002080_prenatal_lethality1.05635253
92MP0002138_abnormal_hepatobiliary_system1.05489243
93MP0003119_abnormal_digestive_system1.05355349
94MP0002102_abnormal_ear_morphology1.04597166
95MP0004145_abnormal_muscle_electrophysio1.02845933
96MP0006072_abnormal_retinal_apoptosis1.01527124
97MP0005389_reproductive_system_phenotype1.00738885
98MP0003787_abnormal_imprinting1.00524484
99MP0005332_abnormal_amino_acid1.00045282
100MP0002233_abnormal_nose_morphology1.00038441
101MP0004381_abnormal_hair_follicle0.99058333
102MP0002452_abnormal_antigen_presenting0.98898332
103MP0005645_abnormal_hypothalamus_physiol0.97895816
104MP0005025_abnormal_response_to0.97740082
105MP0002114_abnormal_axial_skeleton0.97540277
106MP0002837_dystrophic_cardiac_calcinosis0.97390034
107MP0003136_yellow_coat_color0.96783971
108MP0002019_abnormal_tumor_incidence0.95185944
109MP0000432_abnormal_head_morphology0.94269765
110MP0000428_abnormal_craniofacial_morphol0.93025573
111MP0003183_abnormal_peptide_metabolism0.92587860
112MP0001905_abnormal_dopamine_level0.90564682
113MP0002970_abnormal_white_adipose0.87996968
114MP0003195_calcinosis0.85828921
115MP0010307_abnormal_tumor_latency0.85691587
116MP0008875_abnormal_xenobiotic_pharmacok0.85305002
117MP0002160_abnormal_reproductive_system0.83652560
118MP0003878_abnormal_ear_physiology0.82920381
119MP0005377_hearing/vestibular/ear_phenot0.82920381
120MP0003935_abnormal_craniofacial_develop0.82224485
121MP0001119_abnormal_female_reproductive0.81857784
122MP0008872_abnormal_physiological_respon0.81846745
123MP0002210_abnormal_sex_determination0.81114611
124MP0008961_abnormal_basal_metabolism0.80650300
125MP0008469_abnormal_protein_level0.80235262
126MP0001929_abnormal_gametogenesis0.79996731
127MP0003755_abnormal_palate_morphology0.79643018
128MP0005391_vision/eye_phenotype0.78523207
129MP0001286_abnormal_eye_development0.78169179
130MP0001529_abnormal_vocalization0.78125086
131MP0005083_abnormal_biliary_tract0.76729820
132MP0002095_abnormal_skin_pigmentation0.76671865
133MP0000858_altered_metastatic_potential0.76626681
134MP0001853_heart_inflammation0.76165639
135MP0002249_abnormal_larynx_morphology0.76117860
136MP0005220_abnormal_exocrine_pancreas0.76027009
137MP0002751_abnormal_autonomic_nervous0.75916782
138MP0008770_decreased_survivor_rate0.74812996
139MP0005636_abnormal_mineral_homeostasis0.74723749
140MP0000465_gastrointestinal_hemorrhage0.72944683
141MP0000358_abnormal_cell_content/0.72674410
142MP0000689_abnormal_spleen_morphology0.72579854
143MP0008873_increased_physiological_sensi0.71996682
144MP0003186_abnormal_redox_activity0.71905116
145MP0002722_abnormal_immune_system0.71875208
146MP0003937_abnormal_limbs/digits/tail_de0.71419975
147MP0000653_abnormal_sex_gland0.71382321
148MP0005253_abnormal_eye_physiology0.70689383
149MP0001845_abnormal_inflammatory_respons0.69567626
150MP0001986_abnormal_taste_sensitivity0.69422236
151MP0002111_abnormal_tail_morphology0.68598981
152MP0005464_abnormal_platelet_physiology0.68411510
153MP0002925_abnormal_cardiovascular_devel0.67910213
154MP0009703_decreased_birth_body0.66975660
155MP0002098_abnormal_vibrissa_morphology0.65990370
156MP0005023_abnormal_wound_healing0.65989412
157MP0001348_abnormal_lacrimal_gland0.64686831
158MP0005508_abnormal_skeleton_morphology0.63801906
159MP0005384_cellular_phenotype0.63033185
160MP0002116_abnormal_craniofacial_bone0.62699563
161MP0005248_abnormal_Harderian_gland0.62405078
162MP0000750_abnormal_muscle_regeneration0.62196994
163MP0001145_abnormal_male_reproductive0.60387849
164MP0006036_abnormal_mitochondrial_physio0.59850122
165MP0002429_abnormal_blood_cell0.57553945
166MP0003448_altered_tumor_morphology0.57093070
167MP0000703_abnormal_thymus_morphology0.56916493

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.62399023
2Hypochromic microcytic anemia (HP:0004840)5.49192712
3Acute necrotizing encephalopathy (HP:0006965)5.05932405
4Abnormal mitochondria in muscle tissue (HP:0008316)4.99874303
5Multiple enchondromatosis (HP:0005701)4.96010520
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.88517574
7Acute encephalopathy (HP:0006846)4.67400667
8Mitochondrial inheritance (HP:0001427)4.63707390
9Hepatoblastoma (HP:0002884)4.53544032
10Rib fusion (HP:0000902)4.49321733
11Hepatocellular necrosis (HP:0001404)4.47733715
12Chromsome breakage (HP:0040012)4.40823115
13Increased CSF lactate (HP:0002490)4.23556869
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.21717805
15Decreased activity of mitochondrial respiratory chain (HP:0008972)4.21717805
16Ependymoma (HP:0002888)4.03814343
17Hepatic necrosis (HP:0002605)4.03785333
18Progressive macrocephaly (HP:0004481)4.03590060
19Nephroblastoma (Wilms tumor) (HP:0002667)4.00102042
20Increased intramyocellular lipid droplets (HP:0012240)3.83705616
21Rhabdomyosarcoma (HP:0002859)3.78591841
22Neoplasm of striated muscle (HP:0009728)3.71746320
23Embryonal renal neoplasm (HP:0011794)3.70795912
24Cerebral edema (HP:0002181)3.60976875
25Abnormality of the lower motor neuron (HP:0002366)3.55204182
26Abnormal lung lobation (HP:0002101)3.44326154
27Lactic acidosis (HP:0003128)3.40231728
28Increased muscle lipid content (HP:0009058)3.34700487
29Meckel diverticulum (HP:0002245)3.27021796
30Increased serum lactate (HP:0002151)3.25499162
31Rectal fistula (HP:0100590)3.24965293
32Rectovaginal fistula (HP:0000143)3.24965293
33Aplasia/Hypoplasia of the fovea (HP:0008060)3.18935901
34Hypoplasia of the fovea (HP:0007750)3.18935901
35Abnormality of the ileum (HP:0001549)3.07736395
36Partial duplication of thumb phalanx (HP:0009944)3.05996294
37Reduced antithrombin III activity (HP:0001976)3.05399618
38Testicular atrophy (HP:0000029)3.04723445
39Increased hepatocellular lipid droplets (HP:0006565)3.03557185
40Aplasia/Hypoplasia of the uvula (HP:0010293)3.02762024
41Exercise intolerance (HP:0003546)3.01403549
42Trismus (HP:0000211)2.95339365
43Fused cervical vertebrae (HP:0002949)2.94310277
44Impulsivity (HP:0100710)2.92623581
45Intestinal fistula (HP:0100819)2.92109220
46Lipid accumulation in hepatocytes (HP:0006561)2.89294318
47Colon cancer (HP:0003003)2.79975256
48Aplasia/hypoplasia of the humerus (HP:0006507)2.77254587
49Respiratory failure (HP:0002878)2.76479596
50Supernumerary spleens (HP:0009799)2.73851696
51Vaginal fistula (HP:0004320)2.72132293
52Bifid tongue (HP:0010297)2.70963819
53Abnormal number of erythroid precursors (HP:0012131)2.70833355
54Hypochromic anemia (HP:0001931)2.70659397
55Medulloblastoma (HP:0002885)2.68300555
56Ragged-red muscle fibers (HP:0003200)2.67244940
57Anomalous pulmonary venous return (HP:0010772)2.67169854
58Astrocytoma (HP:0009592)2.66518426
59Abnormality of the astrocytes (HP:0100707)2.66518426
60Partial duplication of the phalanx of hand (HP:0009999)2.66452710
61Pancytopenia (HP:0001876)2.65809188
62Aplastic anemia (HP:0001915)2.61380388
63Cerebral palsy (HP:0100021)2.60756072
64Reticulocytopenia (HP:0001896)2.59887510
65Renal Fanconi syndrome (HP:0001994)2.58714187
66Short humerus (HP:0005792)2.57885824
67Small intestinal stenosis (HP:0012848)2.57763294
68Duodenal stenosis (HP:0100867)2.57763294
69Methylmalonic aciduria (HP:0012120)2.55425658
70Abnormality of the salivary glands (HP:0010286)2.55101246
71Preauricular skin tag (HP:0000384)2.54726734
72Dicarboxylic aciduria (HP:0003215)2.54071379
73Abnormality of dicarboxylic acid metabolism (HP:0010995)2.54071379
74Hyperglycinemia (HP:0002154)2.53705555
75Lethargy (HP:0001254)2.52303642
76Optic disc pallor (HP:0000543)2.47957186
77Abnormal protein glycosylation (HP:0012346)2.47840295
78Abnormal glycosylation (HP:0012345)2.47840295
79Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.47840295
80Abnormal protein N-linked glycosylation (HP:0012347)2.47840295
81Panhypogammaglobulinemia (HP:0003139)2.45902330
82Abnormality of cells of the erythroid lineage (HP:0012130)2.45659523
83Decreased electroretinogram (ERG) amplitude (HP:0000654)2.44093969
84Abnormality of the preputium (HP:0100587)2.43171143
85Microretrognathia (HP:0000308)2.42304762
86Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.41631830
87Pendular nystagmus (HP:0012043)2.41539080
88Type I transferrin isoform profile (HP:0003642)2.41003910
89Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.40711796
90Short 5th finger (HP:0009237)2.36155422
91Abnormality of the fovea (HP:0000493)2.34340467
92Abnormal cartilage morphology (HP:0002763)2.33538843
93Glioma (HP:0009733)2.33395284
94Microvesicular hepatic steatosis (HP:0001414)2.32222621
95Abnormality of chromosome segregation (HP:0002916)2.31918091
96Amyotrophic lateral sclerosis (HP:0007354)2.29552808
97Progressive muscle weakness (HP:0003323)2.29002225
98IgM deficiency (HP:0002850)2.28004579
99IgG deficiency (HP:0004315)2.27065807
100Aplasia/Hypoplasia of the sacrum (HP:0008517)2.26319267
101Abnormality of the pulmonary veins (HP:0011718)2.26316600
102Skin tags (HP:0010609)2.24450249
103Hyperinsulinemic hypoglycemia (HP:0000825)2.24309255
104Periauricular skin pits (HP:0100277)2.23542272
105Preauricular pit (HP:0004467)2.23542272
106Abnormality of T cells (HP:0002843)2.20289093
107Abnormality of chromosome stability (HP:0003220)2.20196091
108Hyperglycinuria (HP:0003108)2.19386008
109Large earlobe (HP:0009748)2.19096154
110Cleft eyelid (HP:0000625)2.19071699
111Combined immunodeficiency (HP:0005387)2.17969659
112Myelodysplasia (HP:0002863)2.17535945
113Shawl scrotum (HP:0000049)2.17130875
114Abnormality of the phalanges of the hallux (HP:0010057)2.16893644
115Nasolacrimal duct obstruction (HP:0000579)2.16623612
116Aplasia/Hypoplasia of the sternum (HP:0006714)2.16598726
117Tongue fasciculations (HP:0001308)2.15862233
118Abnormality of serine family amino acid metabolism (HP:0010894)2.15818874
119Abnormality of glycine metabolism (HP:0010895)2.15818874
120Abnormality of the prostate (HP:0008775)2.15532112
121CNS demyelination (HP:0007305)2.15330586
122Rhabdomyolysis (HP:0003201)2.14954092
123Horizontal nystagmus (HP:0000666)2.14795564
124Sloping forehead (HP:0000340)2.14615288
125Methylmalonic acidemia (HP:0002912)2.14082083
1263-Methylglutaconic aciduria (HP:0003535)2.12960683
127Abnormality of the duodenum (HP:0002246)2.11246072
128Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.10687408
129Emotional lability (HP:0000712)2.10550463
130Atresia of the external auditory canal (HP:0000413)2.10520825
131Muscle fiber atrophy (HP:0100295)2.10496092
132Embryonal neoplasm (HP:0002898)2.08922367
133Glossoptosis (HP:0000162)2.07923133
134Abnormality of T cell physiology (HP:0011840)2.06687944
135Duplication of thumb phalanx (HP:0009942)2.06620198
136Stomatitis (HP:0010280)2.05682591
137Premature ovarian failure (HP:0008209)2.05571973
138Aplasia/Hypoplasia of the macula (HP:0008059)2.05463710
139Carpal bone hypoplasia (HP:0001498)2.04864804
140Severe combined immunodeficiency (HP:0004430)2.03971644
141Increased IgM level (HP:0003496)2.03555079
142Respiratory difficulties (HP:0002880)2.03247804
143Atrophy/Degeneration involving motor neurons (HP:0007373)2.02468318
144Leukodystrophy (HP:0002415)2.02001436
145Increased serum pyruvate (HP:0003542)1.99781206
146Type 2 muscle fiber atrophy (HP:0003554)1.99225273
147Absent thumb (HP:0009777)1.98817137
148Malignant neoplasm of the central nervous system (HP:0100836)1.98551488
149Aplasia/hypoplasia of the uterus (HP:0008684)1.98060673
150Abnormality of T cell number (HP:0011839)1.96741524
151Degeneration of anterior horn cells (HP:0002398)1.96634003
152Abnormality of the anterior horn cell (HP:0006802)1.96634003
153Abnormality of small intestinal villus morphology (HP:0011472)1.96378538
154Villous atrophy (HP:0011473)1.96378538
155Horseshoe kidney (HP:0000085)1.95684861
156Bone marrow hypocellularity (HP:0005528)1.95080499
157Facial cleft (HP:0002006)1.94312543
158Cheilitis (HP:0100825)1.92515101
159Selective tooth agenesis (HP:0001592)1.91448804
160T lymphocytopenia (HP:0005403)1.91345490
161Abnormality of the distal phalanx of the thumb (HP:0009617)1.90598212
162Agammaglobulinemia (HP:0004432)1.90060058
163Renal duplication (HP:0000075)1.89444042
164Abnormality of serum amino acid levels (HP:0003112)1.89046297
165Vertebral fusion (HP:0002948)1.88264516
166Muscle fibrillation (HP:0010546)1.88136644
167Triphalangeal thumb (HP:0001199)1.87283427
168Supernumerary ribs (HP:0005815)1.87112809
169Abnormal delayed hypersensitivity skin test (HP:0002963)1.86923355
170Opisthotonus (HP:0002179)1.86911272
171Generalized hypotonia (HP:0001290)1.86167625
172Progressive microcephaly (HP:0000253)1.84904306
173Missing ribs (HP:0000921)1.84762964
174Squamous cell carcinoma (HP:0002860)1.83502140
175Exertional dyspnea (HP:0002875)1.82940041
176Macrocytic anemia (HP:0001972)1.80100042
177Neoplasm of the adrenal gland (HP:0100631)1.78110179
178Abnormality of glycolysis (HP:0004366)1.76966192
179Cutaneous melanoma (HP:0012056)1.75378225
180Cerebral hypomyelination (HP:0006808)1.74778012
181Abnormality of the heme biosynthetic pathway (HP:0010472)1.73882576
182Abolished electroretinogram (ERG) (HP:0000550)1.72212400
183Neutropenia (HP:0001875)1.69516897
184Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.69496604
185Abnormality of alanine metabolism (HP:0010916)1.69496604
186Hyperalaninemia (HP:0003348)1.69496604
187Autoimmune hemolytic anemia (HP:0001890)1.69120024
188Myoglobinuria (HP:0002913)1.67531034
189Encephalitis (HP:0002383)1.64386485

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.78953034
2VRK25.53318913
3GRK54.35678568
4GRK63.91747266
5ERN13.84991746
6TTK3.29637345
7BCKDK3.20778378
8GRK13.01992747
9ADRBK22.96595156
10KDR2.87922093
11TXK2.86825876
12CSF1R2.83495399
13NUAK12.48079126
14STK102.43599271
15TGFBR22.32835957
16STK162.27427076
17CDC72.15939328
18BUB12.15279153
19GRK72.09314633
20PBK2.08715765
21CDK72.07490052
22MAPK72.04138054
23MATK2.02649758
24MAP4K21.99622470
25TYRO31.79214761
26WEE11.77118068
27CHEK21.73349824
28PLK11.71410369
29MOS1.68817277
30NME11.56455726
31DAPK11.49813169
32MAP3K111.41502549
33PAK41.40705834
34NEK21.36855202
35EPHA21.36763910
36WNK11.30881688
37CSNK1G31.29031519
38MAP3K101.28788933
39MAP4K11.26739252
40SRPK11.20276532
41PRKG21.19142470
42CCNB11.17932819
43TAF11.17383575
44CAMK41.17171238
45EIF2AK21.14757188
46MAPKAPK31.12665970
47SMG11.11740713
48PLK31.07438707
49CHEK11.06989239
50TAOK31.02860052
51AURKB0.97491852
52AKT30.96386113
53CDK40.96232660
54TESK10.95696698
55CSNK1G10.95629517
56SCYL20.94662185
57HIPK20.94247982
58PDK20.93504759
59ADRBK10.92441261
60PASK0.90031643
61CSNK1A1L0.89645004
62LIMK10.89210208
63OBSCN0.88837599
64RPS6KA50.86743155
65AURKA0.84385173
66FES0.81087865
67CDK190.80548493
68AKT20.79629858
69MARK20.78763770
70TSSK60.77485646
71CSNK1G20.77320905
72ATR0.73847944
73RPS6KB20.73598557
74ACVR1B0.72482512
75STK40.72289171
76BRSK20.71660885
77MAP2K60.71380153
78TBK10.68861703
79MAP2K40.68767270
80FGFR30.68639419
81CDK20.67909066
82TEC0.67213423
83TESK20.66801197
84ALK0.65806988
85CSK0.64202116
86ABL20.64055744
87DYRK30.62850489
88EIF2AK10.62809499
89MKNK10.62270854
90ATM0.61644090
91PRKCQ0.60320458
92NTRK10.59113055
93DAPK30.58118385
94NME20.58073814
95MKNK20.57395754
96TRIM280.56960195
97NEK10.56888149
98VRK10.55913228
99IKBKE0.55429936
100PLK40.55183724
101PRKCI0.53424923
102LCK0.52318673
103PAK10.50523250
104PINK10.50487215
105CSNK2A20.50442653
106IKBKB0.49414333
107RPS6KA40.48051434
108BLK0.46892040
109MAP2K20.46849639
110MAPKAPK50.45570778
111ILK0.45034260
112BRSK10.44649426
113KIT0.44119524
114MST40.44025298
115TNK20.42881000
116CDK10.42878228
117ZAK0.42408291
118TLK10.42275632
119CDK80.41412022
120BTK0.40632725
121MAPK120.40504549
122LYN0.39693319
123MTOR0.39141801
124PIM10.37806344
125MAP3K80.37678107
126SYK0.37125586
127WNK30.34812758
128MAP2K70.34626429
129LATS20.31184552
130PRKCD0.30196281
131MAP3K70.29904219
132TAOK20.29617386
133YES10.27231284
134CSNK2A10.27011994
135MAPK40.26988664
136CSNK1E0.24703189
137DYRK20.24085328
138ITK0.23989864
139MAPKAPK20.23565137
140MAPK140.23493933
141MAP3K60.22497048
142CHUK0.22370560
143IGF1R0.21806828
144MAPK10.21561281
145PIM20.21130580
146BRD40.21116555
147STK38L0.21066234
148CDK11A0.20418839
149EIF2AK30.20017502
150CLK10.19968936
151ERBB20.18751932
152GSK3B0.18719496
153CDK150.18456807
154FLT30.18141328

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.40001793
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.38128445
3Vitamin B6 metabolism_Homo sapiens_hsa007504.22879230
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.65345035
5Mismatch repair_Homo sapiens_hsa034303.50821043
6Oxidative phosphorylation_Homo sapiens_hsa001903.09114058
7Parkinsons disease_Homo sapiens_hsa050122.92818573
8Homologous recombination_Homo sapiens_hsa034402.86305041
9Ribosome_Homo sapiens_hsa030102.78723769
10Fructose and mannose metabolism_Homo sapiens_hsa000512.53699667
11Base excision repair_Homo sapiens_hsa034102.49922713
12RNA transport_Homo sapiens_hsa030132.49248332
13Fanconi anemia pathway_Homo sapiens_hsa034602.48858343
14Cell cycle_Homo sapiens_hsa041102.37317710
15Spliceosome_Homo sapiens_hsa030402.30674330
16One carbon pool by folate_Homo sapiens_hsa006702.28062932
17Nucleotide excision repair_Homo sapiens_hsa034202.00096974
18Arachidonic acid metabolism_Homo sapiens_hsa005901.97394743
19RNA polymerase_Homo sapiens_hsa030201.94361475
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.94271669
21Galactose metabolism_Homo sapiens_hsa000521.90478297
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.85538742
23Huntingtons disease_Homo sapiens_hsa050161.82407688
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73024260
25Fatty acid elongation_Homo sapiens_hsa000621.70842892
26mRNA surveillance pathway_Homo sapiens_hsa030151.70754208
27RNA degradation_Homo sapiens_hsa030181.67001399
28Pyrimidine metabolism_Homo sapiens_hsa002401.64249526
29Alzheimers disease_Homo sapiens_hsa050101.63772839
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.63420303
31Protein export_Homo sapiens_hsa030601.58592456
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.57637218
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48269691
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.47709351
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.46451725
36Non-homologous end-joining_Homo sapiens_hsa034501.46308366
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.44309801
38p53 signaling pathway_Homo sapiens_hsa041151.40738937
39Linoleic acid metabolism_Homo sapiens_hsa005911.40194852
40Basal transcription factors_Homo sapiens_hsa030221.35468244
41Proteasome_Homo sapiens_hsa030501.30576347
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25798254
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.17544768
44Propanoate metabolism_Homo sapiens_hsa006401.17213640
45Peroxisome_Homo sapiens_hsa041461.13064584
46Graft-versus-host disease_Homo sapiens_hsa053321.12596777
47Thyroid cancer_Homo sapiens_hsa052161.10507007
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10393519
49Autoimmune thyroid disease_Homo sapiens_hsa053201.10047863
50Allograft rejection_Homo sapiens_hsa053301.04922585
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02220489
52Pyruvate metabolism_Homo sapiens_hsa006200.99860107
53Herpes simplex infection_Homo sapiens_hsa051680.97315555
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96183117
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95486942
56Pentose phosphate pathway_Homo sapiens_hsa000300.89053115
57Asthma_Homo sapiens_hsa053100.87446171
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87275406
59Cardiac muscle contraction_Homo sapiens_hsa042600.84876972
60Sulfur relay system_Homo sapiens_hsa041220.80017214
61Folate biosynthesis_Homo sapiens_hsa007900.79452932
62Type I diabetes mellitus_Homo sapiens_hsa049400.78153665
63Sulfur metabolism_Homo sapiens_hsa009200.77967886
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77464515
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73058761
66Other glycan degradation_Homo sapiens_hsa005110.72748636
67Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72094533
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.68482571
69Primary immunodeficiency_Homo sapiens_hsa053400.67993885
70MicroRNAs in cancer_Homo sapiens_hsa052060.67817978
71mTOR signaling pathway_Homo sapiens_hsa041500.67616056
72Basal cell carcinoma_Homo sapiens_hsa052170.65717431
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65597970
74Butanoate metabolism_Homo sapiens_hsa006500.65384584
75Purine metabolism_Homo sapiens_hsa002300.64228930
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59885044
77Fatty acid metabolism_Homo sapiens_hsa012120.58952718
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.57373399
79Rheumatoid arthritis_Homo sapiens_hsa053230.55950888
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55915805
81Tyrosine metabolism_Homo sapiens_hsa003500.55721282
82HTLV-I infection_Homo sapiens_hsa051660.55633512
83Viral carcinogenesis_Homo sapiens_hsa052030.55435044
84Chemical carcinogenesis_Homo sapiens_hsa052040.54414661
85Fatty acid degradation_Homo sapiens_hsa000710.53899331
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.53604018
87Pathways in cancer_Homo sapiens_hsa052000.52515536
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52371664
89Selenocompound metabolism_Homo sapiens_hsa004500.51237430
90Acute myeloid leukemia_Homo sapiens_hsa052210.50236012
91Apoptosis_Homo sapiens_hsa042100.49315173
92Viral myocarditis_Homo sapiens_hsa054160.48736526
93Notch signaling pathway_Homo sapiens_hsa043300.48213694
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47442156
95N-Glycan biosynthesis_Homo sapiens_hsa005100.47354337
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46362112
97Arginine and proline metabolism_Homo sapiens_hsa003300.46030047
98Biosynthesis of amino acids_Homo sapiens_hsa012300.45813721
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45787740
100Systemic lupus erythematosus_Homo sapiens_hsa053220.44602688
101Hedgehog signaling pathway_Homo sapiens_hsa043400.42423876
102Regulation of autophagy_Homo sapiens_hsa041400.42160743
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41108243
104Tryptophan metabolism_Homo sapiens_hsa003800.40993350
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.40386453
106Carbon metabolism_Homo sapiens_hsa012000.40292257
107Epstein-Barr virus infection_Homo sapiens_hsa051690.40235666
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40037903
109Bladder cancer_Homo sapiens_hsa052190.39113343
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38064270
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37222220
112Small cell lung cancer_Homo sapiens_hsa052220.37067323
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.36643128
114beta-Alanine metabolism_Homo sapiens_hsa004100.36114933
115Steroid biosynthesis_Homo sapiens_hsa001000.35490273
116Ether lipid metabolism_Homo sapiens_hsa005650.34458804
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.34396427
118Phenylalanine metabolism_Homo sapiens_hsa003600.34141406
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34003511
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.33328601
121Non-small cell lung cancer_Homo sapiens_hsa052230.30758343
122Glutathione metabolism_Homo sapiens_hsa004800.29968372
123Hippo signaling pathway_Homo sapiens_hsa043900.29485937
124Metabolic pathways_Homo sapiens_hsa011000.28166281
125Cyanoamino acid metabolism_Homo sapiens_hsa004600.28110489
126Oocyte meiosis_Homo sapiens_hsa041140.26643819
127Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26136263
128Inositol phosphate metabolism_Homo sapiens_hsa005620.25303253
129Phototransduction_Homo sapiens_hsa047440.24098540
130Legionellosis_Homo sapiens_hsa051340.23371039
131Ovarian steroidogenesis_Homo sapiens_hsa049130.22903332
132Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22882784
133Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.22769406
134Antigen processing and presentation_Homo sapiens_hsa046120.22749577
135Influenza A_Homo sapiens_hsa051640.19608860
136Phospholipase D signaling pathway_Homo sapiens_hsa040720.19470724
137Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17760141
138Wnt signaling pathway_Homo sapiens_hsa043100.17018890
139Leukocyte transendothelial migration_Homo sapiens_hsa046700.16566951
140Pancreatic cancer_Homo sapiens_hsa052120.15664895
141Hematopoietic cell lineage_Homo sapiens_hsa046400.14949428
142African trypanosomiasis_Homo sapiens_hsa051430.13167771
143Leishmaniasis_Homo sapiens_hsa051400.12841924
144PI3K-Akt signaling pathway_Homo sapiens_hsa041510.12010027
145Colorectal cancer_Homo sapiens_hsa052100.11990000
146Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.11742535
147Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.11221501

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