PMFBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.72670552
2spermatid development (GO:0007286)9.66072690
3motile cilium assembly (GO:0044458)9.31057375
4regulation of cilium movement (GO:0003352)9.03277250
5cilium movement (GO:0003341)8.53093497
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.86896376
7single fertilization (GO:0007338)7.71367559
8sperm capacitation (GO:0048240)7.57060553
9male meiosis (GO:0007140)7.24898600
10piRNA metabolic process (GO:0034587)7.14083235
11synaptonemal complex organization (GO:0070193)7.05481650
12rRNA modification (GO:0000154)6.85646984
13synaptonemal complex assembly (GO:0007130)6.85519567
14negative regulation of inclusion body assembly (GO:0090084)6.68989701
15microtubule depolymerization (GO:0007019)6.65196421
16centriole replication (GO:0007099)6.55145880
17fertilization (GO:0009566)6.46423115
18spermatogenesis (GO:0007283)6.45630258
19male gamete generation (GO:0048232)6.43379907
20organic cation transport (GO:0015695)6.17850677
21gamete generation (GO:0007276)5.92173666
22rRNA methylation (GO:0031167)5.69213266
23regulation of inclusion body assembly (GO:0090083)5.64456296
24ventricular system development (GO:0021591)5.56482353
25calcium ion-dependent exocytosis (GO:0017156)5.46190463
26cellular process involved in reproduction in multicellular organism (GO:0022412)5.38729495
27germ cell development (GO:0007281)5.38393908
28regulation of microtubule-based movement (GO:0060632)5.37837703
29response to pheromone (GO:0019236)5.26496696
30mitochondrial calcium ion transport (GO:0006851)5.23266776
31cell recognition (GO:0008037)5.01938081
32male meiosis I (GO:0007141)5.01626691
33spermatid nucleus differentiation (GO:0007289)4.95340710
34microtubule severing (GO:0051013)4.82529838
35chromosome organization involved in meiosis (GO:0070192)4.68825458
36multicellular organismal reproductive process (GO:0048609)4.68024554
37glycerol ether metabolic process (GO:0006662)4.66133717
38regulation of centriole replication (GO:0046599)4.65151595
39negative regulation of transcription regulatory region DNA binding (GO:2000678)4.58810244
40DNA methylation involved in gamete generation (GO:0043046)4.55826464
41protein targeting to Golgi (GO:0000042)4.55546122
42left/right pattern formation (GO:0060972)4.45604839
43cellular response to thyroid hormone stimulus (GO:0097067)4.39777135
44seminiferous tubule development (GO:0072520)4.39760859
45establishment of protein localization to Golgi (GO:0072600)4.34857557
46chromosome condensation (GO:0030261)4.31840427
47ether metabolic process (GO:0018904)4.30804861
48meiotic nuclear division (GO:0007126)4.29048041
49DNA packaging (GO:0006323)4.11917947
50meiosis I (GO:0007127)4.02700257
51retrograde transport, vesicle recycling within Golgi (GO:0000301)4.02164346
52positive regulation of osteoblast proliferation (GO:0033690)4.00498412
53monoubiquitinated protein deubiquitination (GO:0035520)3.94792112
54chaperone-mediated protein complex assembly (GO:0051131)3.86660987
55single strand break repair (GO:0000012)3.85631186
56ribosomal small subunit biogenesis (GO:0042274)3.83411925
57phosphatidylethanolamine biosynthetic process (GO:0006646)3.77351762
58genitalia morphogenesis (GO:0035112)3.76596037
59protein localization to Golgi apparatus (GO:0034067)3.75658781
60multicellular organismal development (GO:0007275)3.74330144
61protein polyglutamylation (GO:0018095)3.71409347
62positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.68476725
63sexual reproduction (GO:0019953)3.65045136
64ATP synthesis coupled proton transport (GO:0015986)3.61604100
65energy coupled proton transport, down electrochemical gradient (GO:0015985)3.61604100
66cytochrome complex assembly (GO:0017004)3.55290587
67granulocyte differentiation (GO:0030851)3.54209139
68response to thyroid hormone (GO:0097066)3.49687353
69viral transcription (GO:0019083)3.49407808
70microtubule polymerization or depolymerization (GO:0031109)3.44230090
71erythrocyte development (GO:0048821)3.44118055
72phosphatidylethanolamine metabolic process (GO:0046337)3.41709018
73mitochondrial respiratory chain complex I assembly (GO:0032981)3.38376314
74NADH dehydrogenase complex assembly (GO:0010257)3.38376314
75mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.38376314
76meiotic cell cycle (GO:0051321)3.34536108
77protein localization to cilium (GO:0061512)3.34488547
78translational termination (GO:0006415)3.33550659
79protein K11-linked deubiquitination (GO:0035871)3.32130791
80protein complex biogenesis (GO:0070271)3.31763635
81protein refolding (GO:0042026)3.30039930
82respiratory chain complex IV assembly (GO:0008535)3.29239685
83gas transport (GO:0015669)3.20015170
84regulation of spindle checkpoint (GO:0090231)3.19001414
85glycolytic process (GO:0006096)3.15811283
86mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.15663503
87negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.15000784
88oxygen transport (GO:0015671)3.12049014
89histone exchange (GO:0043486)3.09733439
90nucleus organization (GO:0006997)3.09322426
91regulation of transcription involved in cell fate commitment (GO:0060850)3.08759473
92mitochondrial respiratory chain complex assembly (GO:0033108)3.07676368
93negative regulation of bone mineralization (GO:0030502)3.04645075
94nucleoside diphosphate phosphorylation (GO:0006165)3.02596968
95carnitine transport (GO:0015879)3.02328094
96amino-acid betaine transport (GO:0015838)3.02328094
97cilium organization (GO:0044782)3.00883351
98polyol catabolic process (GO:0046174)3.00287473
99microtubule-based movement (GO:0007018)3.00164046
100mitotic sister chromatid cohesion (GO:0007064)2.92932248
101alditol metabolic process (GO:0019400)2.91653040
102intraciliary transport (GO:0042073)2.89898518
103cilium assembly (GO:0042384)2.89530701
104negative regulation of mast cell activation (GO:0033004)2.89290700
105sequestering of actin monomers (GO:0042989)2.89157952
106mannosylation (GO:0097502)2.87891582
107negative regulation of organelle assembly (GO:1902116)2.85687449
108carnitine transmembrane transport (GO:1902603)2.85016909
109SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.83230288
110protein targeting to ER (GO:0045047)2.82402281
111meiotic cell cycle process (GO:1903046)2.82070124
112mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.79989798
113cotranslational protein targeting to membrane (GO:0006613)2.79706689
114GTP biosynthetic process (GO:0006183)2.79403550
115cellular component assembly involved in morphogenesis (GO:0010927)2.78859061
116axoneme assembly (GO:0035082)2.78779530
117RNA localization (GO:0006403)2.78151204
118synapsis (GO:0007129)2.74417059
119ATP biosynthetic process (GO:0006754)2.74310226
120lactate metabolic process (GO:0006089)2.73158079
121regulation of transcription regulatory region DNA binding (GO:2000677)2.73073147
122cilium morphogenesis (GO:0060271)2.72548168
123centriole assembly (GO:0098534)2.70676715
124protein localization to endoplasmic reticulum (GO:0070972)2.70673998
125alanine transport (GO:0032328)2.70480504
126oligosaccharide catabolic process (GO:0009313)2.67550731
127establishment of protein localization to endoplasmic reticulum (GO:0072599)2.67160933
128positive regulation of erythrocyte differentiation (GO:0045648)2.66557610
129ribonucleoprotein complex biogenesis (GO:0022613)2.66188161
130nuclear envelope reassembly (GO:0031468)2.65994146
131mitotic nuclear envelope reassembly (GO:0007084)2.65994146
132cellular ketone body metabolic process (GO:0046950)2.64330725
133regulation of mitochondrial translation (GO:0070129)2.63942069
134translational elongation (GO:0006414)2.63276836
135nuclear pore complex assembly (GO:0051292)2.62853522
136interferon-gamma secretion (GO:0072643)2.61319804
137gene silencing by RNA (GO:0031047)2.60816724
138cellular protein complex disassembly (GO:0043624)2.58626395
139mesonephros development (GO:0001823)2.58089059
140RNA destabilization (GO:0050779)2.57870495
141regulation of centrosome cycle (GO:0046605)2.55864504
142positive regulation of macrophage activation (GO:0043032)2.55578187
143embryonic hemopoiesis (GO:0035162)2.55175344
144oxidative phosphorylation (GO:0006119)2.54185682
145ribosome biogenesis (GO:0042254)2.53579866
146regulation of cilium assembly (GO:1902017)2.52769946
147cellular component biogenesis (GO:0044085)2.52673802
148peptidyl-glutamic acid modification (GO:0018200)2.52589889
149dendritic cell differentiation (GO:0097028)2.51548177
150UTP biosynthetic process (GO:0006228)2.49836328
151polyamine biosynthetic process (GO:0006596)2.49810103
152regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.48288109
153fusion of sperm to egg plasma membrane (GO:0007342)14.0917901
154sperm motility (GO:0030317)13.9316096
155cell wall macromolecule catabolic process (GO:0016998)12.5203416
156cell wall macromolecule metabolic process (GO:0044036)12.5203416
157acrosome reaction (GO:0007340)11.8124229
158sperm-egg recognition (GO:0035036)11.5185890
159multicellular organism reproduction (GO:0032504)11.4627781
160acrosome assembly (GO:0001675)11.3299087
161plasma membrane fusion (GO:0045026)10.7428771
162cilium or flagellum-dependent cell motility (GO:0001539)10.6963272
163epithelial cilium movement (GO:0003351)10.3663565
164binding of sperm to zona pellucida (GO:0007339)10.3340375
165cell-cell recognition (GO:0009988)10.3039370
166axonemal dynein complex assembly (GO:0070286)10.1353014

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.34074864
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.46619154
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.78495892
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.31853654
5EZH2_22144423_ChIP-Seq_EOC_Human4.25336695
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.34716791
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.02754919
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.80565043
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.59493053
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.53544735
11VDR_22108803_ChIP-Seq_LS180_Human2.40982773
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.29809466
13CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.24706561
14ESR1_15608294_ChIP-ChIP_MCF-7_Human2.23757615
15ERA_21632823_ChIP-Seq_H3396_Human2.18336076
16TDRD3_21172665_ChIP-Seq_MCF-7_Human2.15364267
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.13549567
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.12336204
19CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.05327405
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00206910
21EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.99984512
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99597693
23ZNF274_21170338_ChIP-Seq_K562_Hela1.99554666
24GATA1_26923725_Chip-Seq_HPCs_Mouse1.95774516
25BCL6_27268052_Chip-Seq_Bcells_Human1.91751343
26VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.88246095
27EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.87094274
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85345073
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82729066
30KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.81761946
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.80701060
32TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.76543509
33STAT1_17558387_ChIP-Seq_HELA_Human1.71054280
34ELK4_26923725_Chip-Seq_MESODERM_Mouse1.70417726
35GATA3_21878914_ChIP-Seq_MCF-7_Human1.69792579
36EST1_17652178_ChIP-ChIP_JURKAT_Human1.69556604
37RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.66035710
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65268026
39RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.64233485
40BCOR_27268052_Chip-Seq_Bcells_Human1.63852301
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.63415875
42MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.63252689
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62968358
44MYC_19829295_ChIP-Seq_ESCs_Human1.62472048
45CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.61015120
46WDR5_24793694_ChIP-Seq_LNCAP_Human1.60850145
47GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.59126394
48* NANOG_20526341_ChIP-Seq_ESCs_Human1.58463604
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.57469887
50TAF2_19829295_ChIP-Seq_ESCs_Human1.57330509
51IRF1_19129219_ChIP-ChIP_H3396_Human1.57327498
52* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57174511
53P68_20966046_ChIP-Seq_HELA_Human1.55517262
54KAP1_22055183_ChIP-Seq_ESCs_Mouse1.52989842
55OCT4_20526341_ChIP-Seq_ESCs_Human1.52565762
56P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.52505757
57SOX2_22085726_ChIP-Seq_NPCs_Mouse1.52231791
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51116865
59CBP_20019798_ChIP-Seq_JUKART_Human1.51116865
60CTCF_20526341_ChIP-Seq_ESCs_Human1.50828236
61RAC3_21632823_ChIP-Seq_H3396_Human1.50687829
62E2F1_20622854_ChIP-Seq_HELA_Human1.50169735
63KDM2B_26808549_Chip-Seq_REH_Human1.49500355
64FOXA1_27270436_Chip-Seq_PROSTATE_Human1.49452842
65FOXA1_25329375_ChIP-Seq_VCAP_Human1.49452842
66TAL1_26923725_Chip-Seq_HPCs_Mouse1.48455021
67ELF1_20517297_ChIP-Seq_JURKAT_Human1.44731982
68GATA3_21867929_ChIP-Seq_CD8_Mouse1.42553953
69P300_27268052_Chip-Seq_Bcells_Human1.42516006
70ETS1_20019798_ChIP-Seq_JURKAT_Human1.42089221
71ER_23166858_ChIP-Seq_MCF-7_Human1.40027672
72SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.39410413
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36809820
74FOXH1_21741376_ChIP-Seq_ESCs_Human1.36511067
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.36473812
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.36192273
77REST_21632747_ChIP-Seq_MESCs_Mouse1.33148443
78PHF8_20622854_ChIP-Seq_HELA_Human1.32701850
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31767933
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31493588
81LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.30972670
82STAT1_20625510_ChIP-Seq_HELA_Human1.30854144
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29750513
84AR_25329375_ChIP-Seq_VCAP_Human1.29103903
85GATA3_21867929_ChIP-Seq_TH1_Mouse1.28550949
86VDR_23849224_ChIP-Seq_CD4+_Human1.27492948
87PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.27459081
88FLI1_21867929_ChIP-Seq_TH2_Mouse1.27284906
89P53_21459846_ChIP-Seq_SAOS-2_Human1.26767326
90SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26396184
91FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.25594040
92TAF15_26573619_Chip-Seq_HEK293_Human1.25444481
93SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.24781697
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24618637
95CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23993789
96GATA1_22025678_ChIP-Seq_K562_Human1.23395003
97SA1_27219007_Chip-Seq_Bcells_Human1.22018097
98RBPJ_21746931_ChIP-Seq_IB4_Human1.20513617
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20495143
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20495143
101HOXB7_26014856_ChIP-Seq_BT474_Human1.19909590
102NCOR_22424771_ChIP-Seq_293T_Human1.19825481
103* NANOG_19829295_ChIP-Seq_ESCs_Human1.19616686
104* SOX2_19829295_ChIP-Seq_ESCs_Human1.19616686
105GF1_26923725_Chip-Seq_HPCs_Mouse1.18516728
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17035359
107* P300_19829295_ChIP-Seq_ESCs_Human1.16672240
108SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.16082090
109SMC4_20622854_ChIP-Seq_HELA_Human1.15862519
110SOX2_21211035_ChIP-Seq_LN229_Human1.15072186
111CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14880388
112NANOG_18555785_Chip-Seq_ESCs_Mouse1.14481618
113RUNX1_26923725_Chip-Seq_HPCs_Mouse1.14250742
114GATA1_19941826_ChIP-Seq_K562_Human1.14168406
115CRX_20693478_ChIP-Seq_RETINA_Mouse1.13816641
116* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12745464
117RAD21_21589869_ChIP-Seq_MESCs_Mouse1.11885944
118ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11709183
119ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10888603
120AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10029844
121MYC_18940864_ChIP-ChIP_HL60_Human1.09445557
122PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08686590
123YY1_21170310_ChIP-Seq_MESCs_Mouse1.08595862
124PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08531608
125PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08248115
126SPI1_26923725_Chip-Seq_HPCs_Mouse1.07377932
127CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06751204
128RNF2_27304074_Chip-Seq_NSC_Mouse1.06735942
129CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06067542
130GABP_19822575_ChIP-Seq_HepG2_Human1.05974444
131OCT4_18555785_Chip-Seq_ESCs_Mouse1.04917286
132* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04030943
133EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03892152
134ERG_20517297_ChIP-Seq_VCAP_Human1.03661620
135ETV1_20927104_ChIP-Seq_GIST48_Human1.03438396
136P53_22387025_ChIP-Seq_ESCs_Mouse1.02504867
137FOXH1_21741376_ChIP-Seq_EPCs_Human1.01782979
138PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01684601
139TP53_22573176_ChIP-Seq_HFKS_Human1.01612487
140EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01026601
141SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00872000
142BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.00740966
143SMRT_27268052_Chip-Seq_Bcells_Human1.00272297
144SMAD4_21741376_ChIP-Seq_EPCs_Human0.99921260
145CMYC_18555785_Chip-Seq_ESCs_Mouse0.99871882
146LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99290089
147GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.98670732
148GATA6_21074721_ChIP-Seq_CACO-2_Human0.98612431
149MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98390057
150HNFA_21074721_ChIP-Seq_CACO-2_Human0.98201026
151ESET_19884257_ChIP-Seq_ESCs_Mouse0.98190430
152RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97962932
153CBX2_22325352_ChIP-Seq_293T-Rex_Human0.97948473
154OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97188564
155CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96939928
156HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.96784351
157EZH2_27294783_Chip-Seq_NPCs_Mouse0.96314601
158P300_18555785_Chip-Seq_ESCs_Mouse0.95534260
159VDR_24787735_ChIP-Seq_THP-1_Human0.95250543
160GATA3_26560356_Chip-Seq_TH1_Human0.95198642
161RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94885714
162CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.94704858
163SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94689919
164KLF4_18555785_Chip-Seq_ESCs_Mouse0.94333122
165NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.94175521
166CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93927141
167NFYB_21822215_ChIP-Seq_K562_Human0.93633736
168MYC_27129775_Chip-Seq_CORNEA_Mouse0.93415720
169YY1_22570637_ChIP-Seq_MALME-3M_Human0.92067226
170SOX9_26525672_Chip-Seq_HEART_Mouse0.92006046
171RXRA_24833708_ChIP-Seq_LIVER_Mouse0.91836589
172RARA_24833708_ChIP-Seq_LIVER_Mouse0.91769589
173ESRRB_18555785_Chip-Seq_ESCs_Mouse0.91602331
174GATA1_19941827_ChIP-Seq_MEL86_Mouse0.91506388
175NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90810061
176FUS_26573619_Chip-Seq_HEK293_Human0.90609533
177EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.90365307
178TBL1_22424771_ChIP-Seq_293T_Human0.89706740
179STAT3_18555785_ChIP-Seq_MESCs_Mouse0.89381027
180GF1B_26923725_Chip-Seq_HPCs_Mouse0.88734065
181KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.88420423

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002132_abnormal_respiratory_system6.17058993
2MP0003698_abnormal_male_reproductive6.11359203
3MP0001929_abnormal_gametogenesis5.50981711
4MP0008877_abnormal_DNA_methylation4.21474204
5MP0002210_abnormal_sex_determination3.44214429
6MP0002161_abnormal_fertility/fecundity3.35389816
7MP0006292_abnormal_olfactory_placode3.08701912
8MP0001145_abnormal_male_reproductive2.91227764
9MP0003136_yellow_coat_color2.90552297
10MP0005670_abnormal_white_adipose2.81416633
11MP0002653_abnormal_ependyma_morphology2.77454272
12MP0000653_abnormal_sex_gland2.54019264
13MP0005410_abnormal_fertilization16.2408764
14MP0004885_abnormal_endolymph1.93190469
15MP0002254_reproductive_system_inflammat1.92346588
16MP0000372_irregular_coat_pigmentation1.92013682
17MP0001485_abnormal_pinna_reflex1.80719764
18MP0005623_abnormal_meninges_morphology1.80480100
19MP0003718_maternal_effect1.77319055
20MP0008872_abnormal_physiological_respon1.75011791
21MP0002837_dystrophic_cardiac_calcinosis1.74147371
22MP0002138_abnormal_hepatobiliary_system1.73891345
23MP0003693_abnormal_embryo_hatching1.72876234
24MP0004147_increased_porphyrin_level1.69299749
25MP0002160_abnormal_reproductive_system1.61168256
26MP0004510_myositis1.48066469
27MP0003646_muscle_fatigue1.45753044
28MP0002282_abnormal_trachea_morphology1.44046582
29MP0003195_calcinosis1.41622375
30MP0008875_abnormal_xenobiotic_pharmacok1.36236057
31MP0002277_abnormal_respiratory_mucosa1.34756258
32MP0002822_catalepsy1.32853925
33MP0004233_abnormal_muscle_weight1.30072911
34MP0005646_abnormal_pituitary_gland1.19260870
35MP0001765_abnormal_ion_homeostasis1.18517994
36MP0005645_abnormal_hypothalamus_physiol1.14011613
37MP0005084_abnormal_gallbladder_morpholo1.12166735
38MP0009785_altered_susceptibility_to1.09401568
39MP0005360_urolithiasis1.08140354
40MP0003806_abnormal_nucleotide_metabolis1.07643752
41MP0005671_abnormal_response_to1.07567109
42MP0008995_early_reproductive_senescence1.05627677
43MP0000685_abnormal_immune_system1.03804642
44MP0009046_muscle_twitch1.01447575
45MP0002148_abnormal_hypersensitivity_rea1.01275157
46MP0008058_abnormal_DNA_repair1.00628838
47MP0001873_stomach_inflammation1.00595226
48MP0000678_abnormal_parathyroid_gland0.99777409
49MP0009333_abnormal_splenocyte_physiolog0.99167639
50MP0002095_abnormal_skin_pigmentation0.97609652
51MP0003186_abnormal_redox_activity0.97206831
52MP0001984_abnormal_olfaction0.96596786
53MP0005647_abnormal_sex_gland0.94173476
54MP0001188_hyperpigmentation0.94130763
55MP0001905_abnormal_dopamine_level0.93845503
56MP0005377_hearing/vestibular/ear_phenot0.93492871
57MP0003878_abnormal_ear_physiology0.93492871
58MP0005083_abnormal_biliary_tract0.91692805
59MP0009379_abnormal_foot_pigmentation0.90490120
60MP0002249_abnormal_larynx_morphology0.86316141
61MP0008469_abnormal_protein_level0.86064422
62MP0005408_hypopigmentation0.85033719
63MP0000026_abnormal_inner_ear0.83722229
64MP0005379_endocrine/exocrine_gland_phen0.82330858
65MP0005389_reproductive_system_phenotype0.80974257
66MP0001486_abnormal_startle_reflex0.80611459
67MP0005332_abnormal_amino_acid0.80235018
68MP0001963_abnormal_hearing_physiology0.79262989
69MP0000569_abnormal_digit_pigmentation0.75988938
70MP0003115_abnormal_respiratory_system0.75166996
71MP0003436_decreased_susceptibility_to0.74534279
72MP0010329_abnormal_lipoprotein_level0.73740197
73MP0005310_abnormal_salivary_gland0.73349638
74MP0005584_abnormal_enzyme/coenzyme_acti0.70982517
75MP0004142_abnormal_muscle_tone0.70064089
76MP0010386_abnormal_urinary_bladder0.66620004
77MP0009764_decreased_sensitivity_to0.66052941
78MP0005636_abnormal_mineral_homeostasis0.65306352
79MP0002723_abnormal_immune_serum0.65128506
80MP0002876_abnormal_thyroid_physiology0.64402869
81MP0010094_abnormal_chromosome_stability0.63793323
82MP0003656_abnormal_erythrocyte_physiolo0.63122057
83MP0003303_peritoneal_inflammation0.63069901
84MP0003011_delayed_dark_adaptation0.62231441
85MP0003880_abnormal_central_pattern0.61218131
86MP0005174_abnormal_tail_pigmentation0.60264629
87MP0005666_abnormal_adipose_tissue0.60022329
88MP0005365_abnormal_bile_salt0.59574778
89MP0002938_white_spotting0.58743167
90MP0002102_abnormal_ear_morphology0.58537410
91MP0000015_abnormal_ear_pigmentation0.58526358
92MP0002234_abnormal_pharynx_morphology0.57191421
93MP0002127_abnormal_cardiovascular_syste0.57184939
94MP0000049_abnormal_middle_ear0.57181004
95MP0002638_abnormal_pupillary_reflex0.57177156
96MP0003699_abnormal_female_reproductive0.53995284
97MP0000358_abnormal_cell_content/0.52724304
98MP0003950_abnormal_plasma_membrane0.51543454
99MP0001324_abnormal_eye_pigmentation0.50150879
100MP0002928_abnormal_bile_duct0.49149399
101MP0004036_abnormal_muscle_relaxation0.47032593
102MP0001293_anophthalmia0.46700352
103MP0001764_abnormal_homeostasis0.44819715
104MP0003329_amyloid_beta_deposits0.44022820
105MP0005551_abnormal_eye_electrophysiolog0.43314989
106MP0003111_abnormal_nucleus_morphology0.42399024
107MP0005253_abnormal_eye_physiology0.40793749
108MP0002269_muscular_atrophy0.40445230
109MP0003786_premature_aging0.40268810
110MP0003879_abnormal_hair_cell0.39855840
111MP0002736_abnormal_nociception_after0.38523033
112MP0001545_abnormal_hematopoietic_system0.37981115
113MP0005397_hematopoietic_system_phenotyp0.37981115
114MP0009115_abnormal_fat_cell0.36936007
115MP0000534_abnormal_ureter_morphology0.35678917
116MP0009278_abnormal_bone_marrow0.34159290
117MP0008057_abnormal_DNA_replication0.34028394
118MP0002971_abnormal_brown_adipose0.33744543
119MP0001119_abnormal_female_reproductive0.32961071
120MP0005391_vision/eye_phenotype0.32562869
121MP0006036_abnormal_mitochondrial_physio0.31543652
122MP0004742_abnormal_vestibular_system0.29992214
123MP0004811_abnormal_neuron_physiology0.29846669
124MP0008007_abnormal_cellular_replicative0.29516333
125MP0001727_abnormal_embryo_implantation0.29505008
126MP0003861_abnormal_nervous_system0.29263761
127MP0003942_abnormal_urinary_system0.29200563
128MP0001730_embryonic_growth_arrest0.27788439
129MP0000751_myopathy0.27524373
130MP0004133_heterotaxia0.26578713
131MP0002152_abnormal_brain_morphology0.26407137
132MP0004019_abnormal_vitamin_homeostasis0.26146696
133MP0001968_abnormal_touch/_nociception0.25763240
134MP0003633_abnormal_nervous_system0.25430857
135MP0004270_analgesia0.25155038
136MP0003948_abnormal_gas_homeostasis0.22188107
137MP0003787_abnormal_imprinting0.21761703
138MP0002169_no_abnormal_phenotype0.20221796
139MP0002873_normal_phenotype0.19969550
140MP0005423_abnormal_somatic_nervous0.19882491
141MP0003631_nervous_system_phenotype0.19725665
142MP0006035_abnormal_mitochondrial_morpho0.19622364
143MP0010307_abnormal_tumor_latency0.18992324
144MP0008961_abnormal_basal_metabolism0.18683910
145MP0002229_neurodegeneration0.18201675
146MP0002092_abnormal_eye_morphology0.18044145
147MP0002295_abnormal_pulmonary_circulatio0.18005990
148MP0002084_abnormal_developmental_patter0.17640405
149MP0001440_abnormal_grooming_behavior0.17599635
150MP0005375_adipose_tissue_phenotype0.17401237
151MP0000313_abnormal_cell_death0.16786534
152MP0000604_amyloidosis0.16756854
153MP0001849_ear_inflammation0.16193634
154MP0009672_abnormal_birth_weight0.16141407
155MP0002572_abnormal_emotion/affect_behav0.14474679
156MP0001661_extended_life_span0.14183273
157MP0004145_abnormal_muscle_electrophysio0.13844355
158MP0000001_mammalian_phenotype0.13590592
159MP0002139_abnormal_hepatobiliary_system0.12931663
160MP0002693_abnormal_pancreas_physiology0.12643168
161MP0006072_abnormal_retinal_apoptosis0.12612051
162MP0005195_abnormal_posterior_eye0.12541395
163MP0001672_abnormal_embryogenesis/_devel0.12411549

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.26937381
2Abnormal respiratory motile cilium morphology (HP:0005938)9.26937381
3Abnormal respiratory motile cilium physiology (HP:0012261)9.25441375
4Abnormal ciliary motility (HP:0012262)7.50698208
5Rhinitis (HP:0012384)7.43506921
6Chronic bronchitis (HP:0004469)7.06066166
7Infertility (HP:0000789)6.79250630
8Nasal polyposis (HP:0100582)6.27482150
9Short middle phalanx of the 5th finger (HP:0004220)5.31129352
10Abnormality of the nasal mucosa (HP:0000433)5.14450787
11Male infertility (HP:0003251)4.93907473
12Acanthocytosis (HP:0001927)4.64762816
13Bronchitis (HP:0012387)4.58585576
14Bronchiectasis (HP:0002110)4.42806074
15Nephronophthisis (HP:0000090)4.33981191
16Abnormality of the heme biosynthetic pathway (HP:0010472)4.25836185
17Acute necrotizing encephalopathy (HP:0006965)3.72561990
18Abnormal spermatogenesis (HP:0008669)3.71390158
19Mitochondrial inheritance (HP:0001427)3.55590446
20Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.51979979
21Petechiae (HP:0000967)3.45962965
22Abnormality of dental color (HP:0011073)3.44765968
23Recurrent sinusitis (HP:0011108)3.43974352
24Hepatocellular necrosis (HP:0001404)3.37216712
25Recurrent otitis media (HP:0000403)3.32866614
26Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)3.29655928
27Abnormality of the renal medulla (HP:0100957)3.29486926
28Hypoplastic iliac wings (HP:0002866)3.28023531
29Acute encephalopathy (HP:0006846)3.22469490
30Tetany (HP:0001281)3.20627576
31Abnormal mitochondria in muscle tissue (HP:0008316)3.18192124
32Abnormal number of erythroid precursors (HP:0012131)3.17077461
33Tubulointerstitial nephritis (HP:0001970)3.03770883
34Pallor (HP:0000980)3.03717622
35Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.03331544
36Progressive macrocephaly (HP:0004481)3.02459641
37Renal Fanconi syndrome (HP:0001994)3.02205978
38Increased CSF lactate (HP:0002490)3.00002494
39Abnormality of cells of the erythroid lineage (HP:0012130)2.96483379
40Recurrent bronchitis (HP:0002837)2.93598517
41Broad palm (HP:0001169)2.89618872
42Poikilocytosis (HP:0004447)2.89440643
43Reticulocytosis (HP:0001923)2.88978991
44Abnormality of the phalanges of the 5th finger (HP:0004213)2.87671532
45Impulsivity (HP:0100710)2.86213479
46Hepatic necrosis (HP:0002605)2.83935995
47Macrocytic anemia (HP:0001972)2.78388216
48Bony spicule pigmentary retinopathy (HP:0007737)2.75006258
49Severe visual impairment (HP:0001141)2.65677391
50Tubular atrophy (HP:0000092)2.61977812
51Abnormality of midbrain morphology (HP:0002418)2.60656243
52Molar tooth sign on MRI (HP:0002419)2.60656243
53Respiratory difficulties (HP:0002880)2.60011341
54Abnormal rod and cone electroretinograms (HP:0008323)2.59442879
55Aplasia/Hypoplasia of the sacrum (HP:0008517)2.57892961
56Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.51882983
57Protruding tongue (HP:0010808)2.50013637
58Abnormality of reticulocytes (HP:0004312)2.48262119
59Tubulointerstitial abnormality (HP:0001969)2.48227170
60Medial flaring of the eyebrow (HP:0010747)2.46088238
61Polycythemia (HP:0001901)2.45877757
62Attenuation of retinal blood vessels (HP:0007843)2.44754242
63Short 5th finger (HP:0009237)2.44096570
64Increased hepatocellular lipid droplets (HP:0006565)2.41657733
65Gonadotropin excess (HP:0000837)2.40836790
66Azoospermia (HP:0000027)2.34695730
67Cholecystitis (HP:0001082)2.34248637
68Abnormal gallbladder physiology (HP:0012438)2.34248637
69Glycosuria (HP:0003076)2.25535053
70Abnormality of urine glucose concentration (HP:0011016)2.25535053
71Abnormality of renal resorption (HP:0011038)2.24966165
72Brushfield spots (HP:0001088)2.23398505
73Abnormal hemoglobin (HP:0011902)2.23157129
74Small intestinal stenosis (HP:0012848)2.23072690
75Duodenal stenosis (HP:0100867)2.23072690
76Generalized aminoaciduria (HP:0002909)2.21437273
77Lipid accumulation in hepatocytes (HP:0006561)2.20214239
78Aplasia/Hypoplasia of the earlobes (HP:0009906)2.18808272
79Congenital sensorineural hearing impairment (HP:0008527)2.17856040
80Cerebral edema (HP:0002181)2.15036077
81Exertional dyspnea (HP:0002875)2.14860560
82Abnormality of liposaccharide metabolism (HP:0010968)2.12430808
83Abnormality of glycosphingolipid metabolism (HP:0004343)2.12430808
84Abnormality of glycolipid metabolism (HP:0010969)2.12430808
85Polyuria (HP:0000103)2.12345973
86Chronic hepatic failure (HP:0100626)2.11973887
87Abnormal platelet function (HP:0011869)2.07145078
88Impaired platelet aggregation (HP:0003540)2.07145078
89Dyschromatopsia (HP:0007641)2.02199284
90Absent/shortened dynein arms (HP:0200106)13.5447366
91Dynein arm defect of respiratory motile cilia (HP:0012255)13.5447366
92Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1255509
93Albinism (HP:0001022)1.99020345
94Abnormality of macular pigmentation (HP:0008002)1.98808677
95Spastic tetraparesis (HP:0001285)1.97296539
96Abnormality of homocysteine metabolism (HP:0010919)1.95776811
97Homocystinuria (HP:0002156)1.95776811
98Hypothermia (HP:0002045)1.95603342
99Hypoplastic ilia (HP:0000946)1.93432931
100Abnormality of the duodenum (HP:0002246)1.91839823
101Tubulointerstitial fibrosis (HP:0005576)1.90830622
102Abnormality of the wing of the ilium (HP:0011867)1.90445157
103Heterotopia (HP:0002282)1.90180211
104Hypoplasia of the thymus (HP:0000778)1.89504306
105Respiratory failure (HP:0002878)1.87693756
106Postaxial foot polydactyly (HP:0001830)1.86400314
107Optic disc pallor (HP:0000543)1.85858242
108Decreased central vision (HP:0007663)1.85726260
109Hypomagnesemia (HP:0002917)1.82521038
110Hyperinsulinemic hypoglycemia (HP:0000825)1.82372264
111Type I transferrin isoform profile (HP:0003642)1.82199447
112Hyperuricemia (HP:0002149)1.81135073
113Increased purine levels (HP:0004368)1.81135073
114True hermaphroditism (HP:0010459)1.80275094
115Stage 5 chronic kidney disease (HP:0003774)1.78962769
116Anophthalmia (HP:0000528)1.78190074
117Choroideremia (HP:0001139)1.77974417
118Anencephaly (HP:0002323)1.77397908
119Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.75803426
120Bile duct proliferation (HP:0001408)1.73202865
121Abnormal biliary tract physiology (HP:0012439)1.73202865
122Enlarged epiphyses (HP:0010580)1.72358572
123Polydipsia (HP:0001959)1.71950416
124Abnormal drinking behavior (HP:0030082)1.71950416
125Congenital hepatic fibrosis (HP:0002612)1.71779364
126Abnormality of the vertebral endplates (HP:0005106)1.70862454
127Pancreatic cysts (HP:0001737)1.70352085
128Vacuolated lymphocytes (HP:0001922)1.68888958
129Hypoplasia of the capital femoral epiphysis (HP:0003090)1.68852335
130Short ribs (HP:0000773)1.67580047
131Abnormality of the renal cortex (HP:0011035)1.66498094
132Abnormality of the lower motor neuron (HP:0002366)1.64650935
133Abnormality of renal excretion (HP:0011036)1.61211977
134Bell-shaped thorax (HP:0001591)1.60420474
135Oculomotor apraxia (HP:0000657)1.57668152
136Abnormality of the dental root (HP:0006486)1.56829743
137Taurodontia (HP:0000679)1.56829743
138Abnormality of permanent molar morphology (HP:0011071)1.56829743
139Fibular hypoplasia (HP:0003038)1.55226265
140Hemorrhage of the eye (HP:0011885)1.52619345
141Asymmetric septal hypertrophy (HP:0001670)1.50260054
142Microglossia (HP:0000171)1.47235198
143Abnormality of molar (HP:0011077)1.45222335
144Abnormality of molar morphology (HP:0011070)1.45222335
145Postaxial hand polydactyly (HP:0001162)1.45013961
146Renal dysplasia (HP:0000110)1.44948716
147Abnormality of dentin (HP:0010299)1.44388958
148Abnormality of the dental pulp (HP:0006479)1.43979692
149Absent frontal sinuses (HP:0002688)1.42875945
150Cystic liver disease (HP:0006706)1.41958040
151Bundle branch block (HP:0011710)1.41667337
152Amyotrophic lateral sclerosis (HP:0007354)1.39883988
153Pancreatic fibrosis (HP:0100732)1.39797358
154Facial cleft (HP:0002006)1.38614436
155J-shaped sella turcica (HP:0002680)1.36643262
156Neurofibrillary tangles (HP:0002185)1.36143136
157Deformed sella turcica (HP:0002681)1.36074783
158Hemiparesis (HP:0001269)1.35596115
159Aplasia/Hypoplasia of the lens (HP:0008063)1.35208724
160Chronic sinusitis (HP:0011109)1.34705875
161Decreased electroretinogram (ERG) amplitude (HP:0000654)1.34566121
162Gait imbalance (HP:0002141)1.32252266
163Absent epiphyses (HP:0010577)1.32195677
164Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.32195677
165Congenital primary aphakia (HP:0007707)1.31287323
166Abnormal urine output (HP:0012590)1.30377910
167Aplasia/Hypoplasia of the tongue (HP:0010295)1.27417286
168Supernumerary spleens (HP:0009799)1.22925129
169Broad distal phalanx of finger (HP:0009836)1.22872173
170Congenital malformation of the right heart (HP:0011723)1.22339133
171Double outlet right ventricle (HP:0001719)1.22339133
172Abnormality of saccadic eye movements (HP:0000570)1.20692359
173Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.20669215
174Truncal obesity (HP:0001956)1.19024220
175Short thorax (HP:0010306)1.18613330
176Constricted visual fields (HP:0001133)1.17948760
177Nephropathy (HP:0000112)1.17839823
178Abnormality of ocular smooth pursuit (HP:0000617)1.17783455
179Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.17203581
180Cerebral inclusion bodies (HP:0100314)1.16964789
181Pachygyria (HP:0001302)1.13210095
182Easy fatigability (HP:0003388)1.12026533
183Impaired proprioception (HP:0010831)1.11504079

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.35497410
2PDK38.35497410
3TESK15.83788432
4PDK25.38794014
5PRKD35.18309410
6ICK4.18583648
7TAOK33.01552406
8AKT32.58827495
9PNCK2.50005255
10PTK2B2.31208746
11TLK12.22062306
12WNK42.15342536
13ERN12.13260089
14ADRBK22.04071202
15STK392.02375994
16DDR21.95084462
17INSRR1.88345652
18MAP3K91.73226681
19STK381.68017369
20DYRK1B1.58814143
21FRK1.57186856
22NUAK11.55352478
23MAP4K21.52755220
24PLK21.49466461
25NEK21.49065774
26IKBKB1.33182423
27ABL21.27697722
28FLT31.23363231
29MATK1.22927776
30KIT1.22310737
31NME21.20202961
32OXSR11.18655127
33CHUK1.16390352
34CDK191.15813218
35MST41.11250058
36PDK11.09029018
37BMPR1B1.04542052
38CDK71.04433279
39ACVR1B1.03023450
40TNIK1.01966801
41DMPK1.01376437
42VRK21.00042897
43TRPM70.97897394
44TYRO30.96996916
45DYRK30.96543167
46TXK0.95404001
47VRK10.92215178
48CASK0.92012394
49SIK20.88024676
50JAK30.86933445
51DYRK20.86760556
52WNK10.84240485
53RPS6KA60.80494018
54MAPK150.79212459
55CAMK1G0.78418245
56CDK80.76117101
57MAP2K20.75195541
58GRK70.73870794
59RPS6KC10.67613279
60RPS6KL10.67613279
61NLK0.66286038
62BRD40.65580924
63MAP2K60.64700243
64CSF1R0.63523285
65TTK0.63405259
66LMTK20.63350078
67PASK0.62621824
68STK30.62558502
69PDPK10.61021547
70CHEK20.60810744
71IRAK10.56860072
72CCNB10.56547606
73ZAK0.55971703
74GRK10.54758235
75EEF2K0.53961700
76RIPK40.53876244
77TESK20.51575573
78MAP3K70.50673443
79SGK20.50313987
80EPHA30.50085462
81STK38L0.45841628
82CHEK10.45800245
83PAK10.45259988
84RPS6KA20.43165111
85RPS6KA50.43138799
86CAMK10.42913230
87PINK10.42532463
88MKNK20.42377163
89PLK40.41678092
90WEE10.41611204
91SGK10.41249700
92STK40.41176215
93SYK0.41168966
94SGK4940.40248117
95SGK2230.40248117
96NTRK20.39735906
97PRKCI0.38285478
98AKT10.37408878
99AURKB0.37086010
100OBSCN0.34952868
101PAK20.33523032
102ATM0.32510443
103CDC70.31699261
104IRAK20.31336019
105MTOR0.30591876
106PRKCG0.30227888
107NEK60.30076850
108MARK20.26678217
109ATR0.26657170
110MUSK0.26438215
111PRKAA10.22916066
112BRSK20.21289264
113PAK40.20328434
114PLK10.19240346
115CDK120.19170663
116CAMKK10.15802573
117RPS6KB10.15396174
118MAPKAPK50.14939323
119PRKCZ0.14253964
120MAP3K100.13506990
121WNK30.13203671
122CDK150.12772960
123MAP3K40.12222892
124BRSK10.10810083
125CSNK1D0.10763277
126CDK180.10269014
127MARK10.10150995
128GSK3B0.09728510
129CDK11A0.09115199
130CSNK2A10.07334289
131PAK60.07185142
132CDK20.07128924
133PRKCQ0.07103277
134CDK10.06979689
135PKN10.06206243
136STK110.05893718
137RPS6KA10.05870373
138MARK30.05803029
139CDK140.05701457
140CSNK2A20.05405200
141CAMK2A0.04433955
142PRKG10.03079124
143MAPK80.02928037
144PRKG20.02280906
145BRAF0.02275497
146PRKCB0.02124572
147PRKACG0.02112162
148CDK60.01196318
149MAP2K70.00720414
150PRKDC0.00160747
151CDK40.00061205
152MAPK1-0.0279410
153PRKCD-0.0262215
154PRKACA-0.0214276
155EGFR-0.0210105
156CSNK1E-0.0191215
157PRKCA-0.0153370
158RPS6KA3-0.0118477
159MAP3K5-0.0067719
160CDK3-0.0035080
161AURKA-0.0032458
162PRKACB-0.0020023

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.46172060
2Fatty acid biosynthesis_Homo sapiens_hsa000614.37347829
3Ribosome_Homo sapiens_hsa030104.21394297
4Vitamin B6 metabolism_Homo sapiens_hsa007503.74321622
5Oxidative phosphorylation_Homo sapiens_hsa001903.54099392
6Pyruvate metabolism_Homo sapiens_hsa006203.46311170
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.90950421
8Linoleic acid metabolism_Homo sapiens_hsa005912.82612972
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.69982679
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.68325623
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.66803039
12Propanoate metabolism_Homo sapiens_hsa006402.63165777
13Parkinsons disease_Homo sapiens_hsa050122.61891885
14Glucagon signaling pathway_Homo sapiens_hsa049222.52402280
15Basal transcription factors_Homo sapiens_hsa030222.39313797
16Carbohydrate digestion and absorption_Homo sapiens_hsa049732.33953351
17RNA polymerase_Homo sapiens_hsa030202.32555301
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.14577146
19Maturity onset diabetes of the young_Homo sapiens_hsa049502.10209181
20Allograft rejection_Homo sapiens_hsa053302.07544646
21Asthma_Homo sapiens_hsa053102.03253670
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.99765512
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.98909589
24Glycerolipid metabolism_Homo sapiens_hsa005611.98679163
25Type I diabetes mellitus_Homo sapiens_hsa049401.96386839
26Autoimmune thyroid disease_Homo sapiens_hsa053201.93751129
27Selenocompound metabolism_Homo sapiens_hsa004501.89800720
28Oocyte meiosis_Homo sapiens_hsa041141.85996320
29PPAR signaling pathway_Homo sapiens_hsa033201.83077880
30One carbon pool by folate_Homo sapiens_hsa006701.82567878
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.82362425
32Protein export_Homo sapiens_hsa030601.77713652
33Graft-versus-host disease_Homo sapiens_hsa053321.77330640
34Dorso-ventral axis formation_Homo sapiens_hsa043201.77166578
35Homologous recombination_Homo sapiens_hsa034401.76136136
36Pentose phosphate pathway_Homo sapiens_hsa000301.70985185
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.69402908
38Glycerophospholipid metabolism_Homo sapiens_hsa005641.69038863
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.68181046
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64348484
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.64250912
42Fructose and mannose metabolism_Homo sapiens_hsa000511.60211506
43Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.58475230
44Alzheimers disease_Homo sapiens_hsa050101.53052885
45Mineral absorption_Homo sapiens_hsa049781.49912742
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.48743958
47Fanconi anemia pathway_Homo sapiens_hsa034601.46712844
48Amphetamine addiction_Homo sapiens_hsa050311.43191122
49Proteasome_Homo sapiens_hsa030501.40753793
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.39666786
51Cardiac muscle contraction_Homo sapiens_hsa042601.39632345
52Olfactory transduction_Homo sapiens_hsa047401.38992771
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37846595
54Carbon metabolism_Homo sapiens_hsa012001.35903845
55Ether lipid metabolism_Homo sapiens_hsa005651.35108894
56Huntingtons disease_Homo sapiens_hsa050161.30916743
57Fatty acid metabolism_Homo sapiens_hsa012121.26536566
58Fat digestion and absorption_Homo sapiens_hsa049751.25080017
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24503037
60mRNA surveillance pathway_Homo sapiens_hsa030151.23966161
61Fatty acid degradation_Homo sapiens_hsa000711.21306471
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.18684796
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17050670
64Other glycan degradation_Homo sapiens_hsa005111.16552682
65Antigen processing and presentation_Homo sapiens_hsa046121.16184815
66Cysteine and methionine metabolism_Homo sapiens_hsa002701.16172698
67Nucleotide excision repair_Homo sapiens_hsa034201.15415752
68RNA transport_Homo sapiens_hsa030131.12522921
69Renin secretion_Homo sapiens_hsa049241.08582229
70Purine metabolism_Homo sapiens_hsa002301.08346546
71Rheumatoid arthritis_Homo sapiens_hsa053231.08240339
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.97711519
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97005129
74Spliceosome_Homo sapiens_hsa030400.93293087
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93092990
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92009064
77DNA replication_Homo sapiens_hsa030300.90021656
78Biosynthesis of amino acids_Homo sapiens_hsa012300.87684043
79Hedgehog signaling pathway_Homo sapiens_hsa043400.86503395
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.85860661
81Collecting duct acid secretion_Homo sapiens_hsa049660.85677112
82Staphylococcus aureus infection_Homo sapiens_hsa051500.85364275
83Insulin secretion_Homo sapiens_hsa049110.84061292
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82843065
85Base excision repair_Homo sapiens_hsa034100.82240470
86Glutathione metabolism_Homo sapiens_hsa004800.81488886
87Butanoate metabolism_Homo sapiens_hsa006500.81246786
88Phototransduction_Homo sapiens_hsa047440.78784837
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78740570
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77576427
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77535329
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77496638
93Estrogen signaling pathway_Homo sapiens_hsa049150.76466992
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75867313
95Regulation of autophagy_Homo sapiens_hsa041400.73402049
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.73159840
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.72176089
98Thyroid hormone synthesis_Homo sapiens_hsa049180.72140599
99Renin-angiotensin system_Homo sapiens_hsa046140.71083263
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.71062991
101Bile secretion_Homo sapiens_hsa049760.70966227
102Arachidonic acid metabolism_Homo sapiens_hsa005900.69104574
103Mismatch repair_Homo sapiens_hsa034300.68785319
104Retinol metabolism_Homo sapiens_hsa008300.67809979
105Long-term potentiation_Homo sapiens_hsa047200.65277312
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63259227
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62823712
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62725279
109Chemical carcinogenesis_Homo sapiens_hsa052040.62615199
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.59263474
111Primary immunodeficiency_Homo sapiens_hsa053400.59185425
112Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58416388
113Legionellosis_Homo sapiens_hsa051340.56948530
114Peroxisome_Homo sapiens_hsa041460.55584569
115Calcium signaling pathway_Homo sapiens_hsa040200.55172855
116Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52981270
117Taste transduction_Homo sapiens_hsa047420.52393964
118Protein digestion and absorption_Homo sapiens_hsa049740.52211693
119Sulfur relay system_Homo sapiens_hsa041220.52019269
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51920192
121Synaptic vesicle cycle_Homo sapiens_hsa047210.51665650
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50829470
123Salivary secretion_Homo sapiens_hsa049700.50240774
124Inositol phosphate metabolism_Homo sapiens_hsa005620.49507369
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47382988
126Pancreatic secretion_Homo sapiens_hsa049720.47002944
127Tryptophan metabolism_Homo sapiens_hsa003800.46671607
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45929326
129Endocytosis_Homo sapiens_hsa041440.45809986
130Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45359949
131AMPK signaling pathway_Homo sapiens_hsa041520.45022915
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44845969
133Gastric acid secretion_Homo sapiens_hsa049710.44456943
134Nitrogen metabolism_Homo sapiens_hsa009100.44379359
135ABC transporters_Homo sapiens_hsa020100.44274217
136Caffeine metabolism_Homo sapiens_hsa002320.43887209
137African trypanosomiasis_Homo sapiens_hsa051430.42606003
138NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42130784
139Nicotine addiction_Homo sapiens_hsa050330.41951149
140Sphingolipid metabolism_Homo sapiens_hsa006000.41303211
141Epstein-Barr virus infection_Homo sapiens_hsa051690.40403795
142Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38071218
143Lysosome_Homo sapiens_hsa041420.38007723
144Metabolic pathways_Homo sapiens_hsa011000.37256066
145Leishmaniasis_Homo sapiens_hsa051400.37205870
146Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35978175
147Vascular smooth muscle contraction_Homo sapiens_hsa042700.34939436
148cAMP signaling pathway_Homo sapiens_hsa040240.34654888
149Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33004014
150Circadian entrainment_Homo sapiens_hsa047130.32892281
151Pyrimidine metabolism_Homo sapiens_hsa002400.32232343
152Systemic lupus erythematosus_Homo sapiens_hsa053220.31473203
153Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30121386
154Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29270491
155VEGF signaling pathway_Homo sapiens_hsa043700.28760037
156Cocaine addiction_Homo sapiens_hsa050300.22163437
157Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.16969325
158Sulfur metabolism_Homo sapiens_hsa009200.16045120
159RNA degradation_Homo sapiens_hsa030180.14919877
160Alcoholism_Homo sapiens_hsa050340.11231495
161Wnt signaling pathway_Homo sapiens_hsa043100.10853777
162N-Glycan biosynthesis_Homo sapiens_hsa005100.10270546
163Basal cell carcinoma_Homo sapiens_hsa052170.09934777
164Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.09860094
165Type II diabetes mellitus_Homo sapiens_hsa049300.08890424
166Cell cycle_Homo sapiens_hsa041100.08812932
167HIF-1 signaling pathway_Homo sapiens_hsa040660.07698903

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