PML

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)9.04053330
2polyketide metabolic process (GO:0030638)9.04053330
3doxorubicin metabolic process (GO:0044598)9.04053330
4protein localization to kinetochore (GO:0034501)6.27835497
5regulation of nuclear cell cycle DNA replication (GO:0033262)5.82038833
6aminoglycoside antibiotic metabolic process (GO:0030647)5.75309099
7histone H4-K12 acetylation (GO:0043983)5.37873429
8type I interferon signaling pathway (GO:0060337)5.31189670
9cellular response to type I interferon (GO:0071357)5.31189670
10response to type I interferon (GO:0034340)5.31011128
11regulation of mammary gland epithelial cell proliferation (GO:0033599)5.23609930
12negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.23206580
13histone H4-K8 acetylation (GO:0043982)5.03116055
14histone H4-K5 acetylation (GO:0043981)5.03116055
15mitotic sister chromatid segregation (GO:0000070)5.01519619
16negative regulation of epidermis development (GO:0045683)4.97792757
17somite rostral/caudal axis specification (GO:0032525)4.90613350
18negative regulation of cell cycle G2/M phase transition (GO:1902750)4.83710207
19nuclear pore complex assembly (GO:0051292)4.82729303
20heterochromatin organization (GO:0070828)4.82328511
21protein localization to chromosome, centromeric region (GO:0071459)4.81355631
22muscle organ morphogenesis (GO:0048644)4.78332414
23negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.65060023
24rRNA transcription (GO:0009303)4.64194477
25regulation of response to osmotic stress (GO:0047484)4.63720619
26antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.49877392
27interferon-gamma production (GO:0032609)4.44973519
28positive regulation of DNA-dependent DNA replication (GO:2000105)4.44343550
29nuclear pore organization (GO:0006999)4.36451348
30sister chromatid segregation (GO:0000819)4.32536702
31antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.29591866
32chromatin assembly (GO:0031497)4.27770636
33DNA replication-dependent nucleosome assembly (GO:0006335)4.27314600
34DNA replication-dependent nucleosome organization (GO:0034723)4.27314600
35antigen processing and presentation of endogenous antigen (GO:0019883)4.19773646
36regulation of T-helper 1 cell differentiation (GO:0045625)4.16171427
37DNA replication checkpoint (GO:0000076)4.12611984
38response to peptidoglycan (GO:0032494)4.12598497
39positive regulation of gamma-delta T cell activation (GO:0046645)4.10265238
40pre-miRNA processing (GO:0031054)3.99585446
41negative regulation of interleukin-12 production (GO:0032695)3.96070561
42negative regulation of epidermal cell differentiation (GO:0045605)3.95038475
43histone H4-K16 acetylation (GO:0043984)3.92688692
44immunoglobulin mediated immune response (GO:0016064)3.92384135
45NIK/NF-kappaB signaling (GO:0038061)3.86515725
46regulation of dendritic cell antigen processing and presentation (GO:0002604)3.78071245
47negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.76686894
48negative regulation of cell killing (GO:0031342)3.76686894
49notochord development (GO:0030903)3.75989675
50cytidine deamination (GO:0009972)3.75133277
51cytidine metabolic process (GO:0046087)3.75133277
52cytidine catabolic process (GO:0006216)3.75133277
53regulation of gene silencing by RNA (GO:0060966)3.73739596
54regulation of posttranscriptional gene silencing (GO:0060147)3.73739596
55regulation of gene silencing by miRNA (GO:0060964)3.73739596
56* maintenance of protein location in nucleus (GO:0051457)3.73257829
57regulation of interferon-alpha production (GO:0032647)3.72376786
58rRNA methylation (GO:0031167)3.71366104
59DNA unwinding involved in DNA replication (GO:0006268)3.69262203
60macrophage activation involved in immune response (GO:0002281)3.67759894
61pore complex assembly (GO:0046931)3.67337487
62positive regulation by symbiont of host defense response (GO:0052509)3.67286791
63modulation by symbiont of host defense response (GO:0052031)3.67286791
64modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.67286791
65modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.67286791
66positive regulation by organism of defense response of other organism involved in symbiotic interact3.67286791
67modulation by symbiont of host immune response (GO:0052553)3.67286791
68RNA stabilization (GO:0043489)3.66214091
69mRNA stabilization (GO:0048255)3.66214091
70* interferon-gamma-mediated signaling pathway (GO:0060333)3.66151119
71DNA duplex unwinding (GO:0032508)3.65264804
72regulation of type I interferon-mediated signaling pathway (GO:0060338)3.62704563
73DNA geometric change (GO:0032392)3.60853609
74nucleoside transmembrane transport (GO:1901642)3.59699648
75negative regulation of viral genome replication (GO:0045071)3.55876445
76germinal center formation (GO:0002467)3.54883986
77response to interferon-alpha (GO:0035455)3.52233100
78regulation of vitamin D biosynthetic process (GO:0060556)3.51800605
79rRNA modification (GO:0000154)3.51028485
80lipopolysaccharide-mediated signaling pathway (GO:0031663)3.50890205
81response to muramyl dipeptide (GO:0032495)3.45818523
82defense response to protozoan (GO:0042832)3.44824919
83antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.43125456
84formation of translation preinitiation complex (GO:0001731)3.42517329
85cellular response to exogenous dsRNA (GO:0071360)3.41295768
86positive regulation of interferon-alpha production (GO:0032727)3.40864582
87primitive streak formation (GO:0090009)3.39755659
88detection of other organism (GO:0098543)3.39594919
89detection of bacterium (GO:0016045)3.39578419
90hormone catabolic process (GO:0042447)3.39308530
91response to protozoan (GO:0001562)3.37828271
92myeloid dendritic cell differentiation (GO:0043011)3.37051260
93negative regulation of erythrocyte differentiation (GO:0045647)3.36838051
94trophectodermal cell differentiation (GO:0001829)3.35008053
95regulation of interferon-beta biosynthetic process (GO:0045357)3.33250867
96negative regulation of cytokine production involved in immune response (GO:0002719)3.32584132
97positive regulation of type 2 immune response (GO:0002830)3.31822414
98T-helper 1 type immune response (GO:0042088)3.31477428
99cell fate commitment involved in formation of primary germ layer (GO:0060795)3.29860517
100response to interferon-beta (GO:0035456)3.28646031
101ribosome biogenesis (GO:0042254)3.28639882
102regulation of antigen processing and presentation (GO:0002577)3.28383902
103negative regulation of gene silencing (GO:0060969)3.28218509
104mitotic chromosome condensation (GO:0007076)3.27411948
105maternal placenta development (GO:0001893)3.24141238
106positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.19451147
107positive regulation of antigen processing and presentation (GO:0002579)3.13119285
108cellular response to interferon-alpha (GO:0035457)3.08526931
109DNA replication initiation (GO:0006270)3.08087690
110regulation of DNA-dependent DNA replication (GO:0090329)3.06408122
111regulation of gamma-delta T cell activation (GO:0046643)3.06092775
112cellular response to virus (GO:0098586)3.04854726
113ribosomal small subunit biogenesis (GO:0042274)3.04440344
114positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.03933343
115regulation of type 2 immune response (GO:0002828)3.03772549
116positive regulation of natural killer cell differentiation (GO:0032825)3.02274462
117regulation of cilium movement (GO:0003352)3.00727667
118myeloid dendritic cell activation (GO:0001773)2.98815579
119intestinal epithelial cell development (GO:0060576)2.97745541
120regulation of chronic inflammatory response (GO:0002676)2.97098577
121phenol-containing compound catabolic process (GO:0019336)2.95743236
122regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.93518908
123DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.93226857
124negative regulation of innate immune response (GO:0045824)2.92090227
125regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.91160227
126negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.89767581
127establishment of endothelial barrier (GO:0061028)2.88940409
128spindle assembly (GO:0051225)2.88457621
129quinone metabolic process (GO:1901661)2.88331456
130leukocyte aggregation (GO:0070486)2.87692736
131positive regulation of chemokine biosynthetic process (GO:0045080)2.86485941
132regulation of gene silencing (GO:0060968)2.86252336
133* cellular response to interferon-gamma (GO:0071346)2.85688548
134regulation of chemokine biosynthetic process (GO:0045073)2.85588381
135negative regulation of nitric oxide biosynthetic process (GO:0045019)2.85419965
136intracellular estrogen receptor signaling pathway (GO:0030520)2.84608935
137mature B cell differentiation involved in immune response (GO:0002313)2.84263507
138positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.84195401
139mitotic nuclear envelope disassembly (GO:0007077)2.84082511
140regulation of vitamin metabolic process (GO:0030656)2.84009582
141regulation of cytokine secretion involved in immune response (GO:0002739)2.83195822
142histone H3-K4 methylation (GO:0051568)2.83144041
143detection of external biotic stimulus (GO:0098581)2.82662410
144transcription from mitochondrial promoter (GO:0006390)2.82145602
145B cell mediated immunity (GO:0019724)2.81357674
146pseudouridine synthesis (GO:0001522)2.80419801
147T cell migration (GO:0072678)2.80112575
148JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.78529171
149negative regulation of phagocytosis (GO:0050765)2.78058769
150response to dietary excess (GO:0002021)2.77891274
151negative regulation of T cell mediated immunity (GO:0002710)2.76077051
152activation of MAPKKK activity (GO:0000185)2.75756151
153DNA conformation change (GO:0071103)2.75164784
154mitochondrial DNA replication (GO:0006264)2.74318819
155mitochondrion distribution (GO:0048311)2.73808776
156regulation of T-helper 2 cell differentiation (GO:0045628)2.73469570
157regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.73324041
158* response to interferon-gamma (GO:0034341)2.72926692
159dendritic cell differentiation (GO:0097028)2.72888744
160lymphocyte chemotaxis (GO:0048247)2.72674309
161positive regulation of interferon-beta production (GO:0032728)2.72144165
162neutrophil activation involved in immune response (GO:0002283)2.71282895
163regulation of T cell tolerance induction (GO:0002664)2.71254716
164positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.71236116
165apoptotic DNA fragmentation (GO:0006309)2.70282034
166positive regulation of protein import into nucleus, translocation (GO:0033160)2.69857183
167coenzyme catabolic process (GO:0009109)2.69055909
168histone H3 acetylation (GO:0043966)2.68038146
169DNA damage response, detection of DNA damage (GO:0042769)2.68023030
170pteridine-containing compound biosynthetic process (GO:0042559)2.67662259
171positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.67162238
172CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.66783440
173regulation of interleukin-12 production (GO:0032655)2.66728351
174regulation of T-helper cell differentiation (GO:0045622)2.66452235
175cellular response to interferon-beta (GO:0035458)2.66069274
176tachykinin receptor signaling pathway (GO:0007217)2.66060458
177ribonucleoprotein complex biogenesis (GO:0022613)2.65733334
178regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.65673455
179nucleoside transport (GO:0015858)2.64962928
180response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.64666772
181response to host immune response (GO:0052572)2.64666772
182interferon-gamma secretion (GO:0072643)2.62756091
183regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.61314439
184cardiovascular system development (GO:0072358)2.61075161
185DNA damage response, signal transduction resulting in transcription (GO:0042772)2.60793630
186regulation of hippo signaling (GO:0035330)2.60125275
187mannose metabolic process (GO:0006013)2.59342969
188determination of adult lifespan (GO:0008340)2.58922368
189protein localization to chromosome (GO:0034502)2.58896928
190mitotic G2/M transition checkpoint (GO:0044818)2.58714477
191response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.58177996
192response to host (GO:0075136)2.58177996
193response to host defenses (GO:0052200)2.58177996
194membrane disassembly (GO:0030397)2.58170630
195nuclear envelope disassembly (GO:0051081)2.58170630
196negative regulation of production of molecular mediator of immune response (GO:0002701)2.56991906
197regulation of podosome assembly (GO:0071801)2.56776366
198tolerance induction (GO:0002507)2.56567609
199* defense response to virus (GO:0051607)2.55992025
200positive regulation of T-helper cell differentiation (GO:0045624)2.55448949

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.42694005
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.16707907
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.16707907
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.16707907
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.98778717
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.70875687
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.19371214
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.96631857
9RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.95684876
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.84119544
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.74293133
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.60186710
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.58073363
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.56198598
15* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.54275716
16* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.51231618
17MYC_22102868_ChIP-Seq_BL_Human2.36363075
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.36284455
19* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.35729743
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.33941449
21VDR_24763502_ChIP-Seq_THP-1_Human2.24368364
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.22207255
23SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.21754784
24RARG_19884340_ChIP-ChIP_MEFs_Mouse2.18964565
25* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.18233851
26LXR_22292898_ChIP-Seq_THP-1_Human2.17895353
27MYC_18555785_ChIP-Seq_MESCs_Mouse2.17099285
28* TP63_19390658_ChIP-ChIP_HaCaT_Human2.16514422
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.14988159
30* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.12670995
31* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.11181222
32TCF3_18692474_ChIP-Seq_MEFs_Mouse2.08977697
33TCF3_18692474_ChIP-Seq_MESCs_Mouse2.02029335
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.96308520
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.95405083
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.95262191
37NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.94566523
38STAT3_1855785_ChIP-Seq_MESCs_Mouse1.92593961
39* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.92255931
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.87052533
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.86644719
42KDM2B_26808549_Chip-Seq_DND41_Human1.84132871
43TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.81998699
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.76851410
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.75051892
46STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.70839301
47NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.69626453
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.69293747
49MYC_19030024_ChIP-ChIP_MESCs_Mouse1.67599155
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63620856
51ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.62900517
52* SPI1_23127762_ChIP-Seq_K562_Human1.60849362
53* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.57810550
54ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.56492269
55MAF_26560356_Chip-Seq_TH2_Human1.55306481
56RACK7_27058665_Chip-Seq_MCF-7_Human1.53067519
57NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.52955744
58NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.52438293
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51772834
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.48983456
61MYB_26560356_Chip-Seq_TH2_Human1.48568630
62RUNX_20019798_ChIP-Seq_JUKART_Human1.48432736
63* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47995901
64MYC_18358816_ChIP-ChIP_MESCs_Mouse1.45217617
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.44475001
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.43946052
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43609502
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43566648
69SCL_19346495_ChIP-Seq_HPC-7_Human1.42864156
70HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41620711
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.39791967
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.35562982
73PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.34478807
74TCF7_22412390_ChIP-Seq_EML_Mouse1.32782620
75GATA1_19941827_ChIP-Seq_MEL_Mouse1.32769608
76* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30557821
77* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.29824363
78Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29678632
79GATA1_19941826_ChIP-Seq_K562_Human1.29671720
80TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.28477944
81* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.26729591
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26643342
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.26434601
84* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25067966
85* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.25004294
86BCL6_27268052_Chip-Seq_Bcells_Human1.23519181
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23466944
88GATA1_22025678_ChIP-Seq_K562_Human1.23438626
89SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23265619
90IRF1_19129219_ChIP-ChIP_H3396_Human1.23091721
91PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23073449
92CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22886439
93VDR_24787735_ChIP-Seq_THP-1_Human1.22114012
94RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21313252
95VDR_21846776_ChIP-Seq_THP-1_Human1.20589507
96ELF1_20517297_ChIP-Seq_JURKAT_Human1.20511208
97BCOR_27268052_Chip-Seq_Bcells_Human1.18823076
98CTCF_27219007_Chip-Seq_ERYTHROID_Human1.18454958
99* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.17737065
100TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.17669134
101IRF8_22096565_ChIP-ChIP_GC-B_Human1.17522959
102LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17470137
103* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.17084937
104* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.15504333
105SA1_27219007_Chip-Seq_ERYTHROID_Human1.15414236
106* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.15199042
107* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.14996268
108KDM2B_26808549_Chip-Seq_JURKAT_Human1.14775759
109CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13490065
110YY1_21170310_ChIP-Seq_MESCs_Mouse1.13025304
111NCOR1_26117541_ChIP-Seq_K562_Human1.11982942
112* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.11832915
113KDM2B_26808549_Chip-Seq_K562_Human1.11749534
114GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11400998
115CREB1_15753290_ChIP-ChIP_HEK293T_Human1.11114043
116SOX2_18692474_ChIP-Seq_MESCs_Mouse1.09628071
117FOXP3_21729870_ChIP-Seq_TREG_Human1.08832818
118* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08621280
119KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.06284737
120SOX2_18692474_ChIP-Seq_MEFs_Mouse1.06152842
121PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05707118
122* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05602558
123* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04918070
124STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04879512
125CIITA_25753668_ChIP-Seq_RAJI_Human1.04879410
126ELK3_25401928_ChIP-Seq_HUVEC_Human1.04708704
127ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04585229
128EST1_17652178_ChIP-ChIP_JURKAT_Human1.04134864
129NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04124247
130UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03880008
131P68_20966046_ChIP-Seq_HELA_Human1.03140482
132CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02095570
133KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02011341
134STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01446547
135* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01176715
136XRN2_22483619_ChIP-Seq_HELA_Human1.00811526
137VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00614771
138KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00109671
139TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99683661
140NANOG_21062744_ChIP-ChIP_HESCs_Human0.99174085
141KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99039632
142KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99031876
143KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98818612
144MYB_26560356_Chip-Seq_TH1_Human0.97785303
145ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97349868
146FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97193295
147* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97173434
148PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96800829
149NELFA_20434984_ChIP-Seq_ESCs_Mouse0.96548126
150* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.95370733
151* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.94907255
152CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94883698
153* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94860471
154SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94530480
155* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94025591
156IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92740011
157NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92518949
158E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92167792
159KDM5A_27292631_Chip-Seq_BREAST_Human0.91307033
160* SPI1_23547873_ChIP-Seq_NB4_Human0.87471491
161* MAF_26560356_Chip-Seq_TH1_Human0.87159927
162TP53_22127205_ChIP-Seq_IMR90_Human0.86879513
163E2F1_17053090_ChIP-ChIP_MCF-7_Human0.86027822
164UTX_26944678_Chip-Seq_JUKART_Human0.85623745
165* NANOG_16518401_ChIP-PET_MESCs_Mouse0.84736771
166E2F1_21310950_ChIP-Seq_MCF-7_Human0.84696673
167* RUNX1_22412390_ChIP-Seq_EML_Mouse0.83684921
168KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.83566706
169ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.83514155
170KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.83316588
171MYCN_18555785_ChIP-Seq_MESCs_Mouse0.83178611
172IRF8_21731497_ChIP-ChIP_J774_Mouse0.83085830
173KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.82477289
174TFEB_21752829_ChIP-Seq_HELA_Human0.81776176
175CDX2_20551321_ChIP-Seq_CACO-2_Human0.81716688
176AR_21909140_ChIP-Seq_LNCAP_Human0.81052635

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.47449167
2MP0003724_increased_susceptibility_to3.90291498
3MP0002254_reproductive_system_inflammat3.89122566
4MP0004264_abnormal_extraembryonic_tissu3.74840398
5MP0008057_abnormal_DNA_replication3.65306718
6MP0003011_delayed_dark_adaptation3.25811433
7MP0006292_abnormal_olfactory_placode3.15033479
8MP0004957_abnormal_blastocyst_morpholog3.11701921
9MP0009785_altered_susceptibility_to3.02730611
10MP0003300_gastrointestinal_ulcer2.88067359
11MP0010352_gastrointestinal_tract_polyps2.83613796
12MP0005075_abnormal_melanosome_morpholog2.80160838
13MP0003890_abnormal_embryonic-extraembry2.76030986
14MP0002148_abnormal_hypersensitivity_rea2.71839699
15* MP0005025_abnormal_response_to2.56372913
16MP0004510_myositis2.52315910
17MP0003705_abnormal_hypodermis_morpholog2.43710470
18MP0002419_abnormal_innate_immunity2.42795584
19MP0002396_abnormal_hematopoietic_system2.30746054
20MP0005058_abnormal_lysosome_morphology2.28904353
21MP0001533_abnormal_skeleton_physiology2.20628536
22MP0003077_abnormal_cell_cycle2.15206162
23MP0005394_taste/olfaction_phenotype2.12899965
24MP0005499_abnormal_olfactory_system2.12899965
25MP0009278_abnormal_bone_marrow2.10364075
26MP0004947_skin_inflammation2.08559932
27MP0002332_abnormal_exercise_endurance2.02951826
28MP0003111_abnormal_nucleus_morphology1.96635366
29MP0005257_abnormal_intraocular_pressure1.96275379
30MP0004858_abnormal_nervous_system1.95603452
31MP0010094_abnormal_chromosome_stability1.92944047
32MP0001672_abnormal_embryogenesis/_devel1.88991441
33MP0005380_embryogenesis_phenotype1.88991441
34MP0005451_abnormal_body_composition1.86504430
35MP0003121_genomic_imprinting1.81056706
36MP0009840_abnormal_foam_cell1.78605407
37MP0002088_abnormal_embryonic_growth/wei1.77827932
38MP0003984_embryonic_growth_retardation1.77079205
39MP0006082_CNS_inflammation1.76106438
40MP0009764_decreased_sensitivity_to1.75809323
41* MP0000350_abnormal_cell_proliferation1.67400421
42MP0003191_abnormal_cellular_cholesterol1.64979248
43MP0000490_abnormal_crypts_of1.63737934
44MP0002653_abnormal_ependyma_morphology1.63586136
45MP0001845_abnormal_inflammatory_respons1.62180284
46MP0003075_altered_response_to1.61509253
47MP0003172_abnormal_lysosome_physiology1.59306811
48MP0003122_maternal_imprinting1.58067166
49MP0002086_abnormal_extraembryonic_tissu1.51147130
50MP0000343_altered_response_to1.50539144
51MP0003693_abnormal_embryo_hatching1.49188460
52MP0006035_abnormal_mitochondrial_morpho1.48780872
53MP0008961_abnormal_basal_metabolism1.47869822
54MP0008469_abnormal_protein_level1.46242831
55MP0008438_abnormal_cutaneous_collagen1.44832030
56MP0003279_aneurysm1.44287176
57MP0001293_anophthalmia1.43177015
58MP0001849_ear_inflammation1.41270540
59MP0001835_abnormal_antigen_presentation1.40898800
60MP0008004_abnormal_stomach_pH1.39881930
61MP0000678_abnormal_parathyroid_gland1.39773098
62MP0003453_abnormal_keratinocyte_physiol1.38481467
63MP0002998_abnormal_bone_remodeling1.38310843
64MP0002138_abnormal_hepatobiliary_system1.38002029
65MP0002277_abnormal_respiratory_mucosa1.37085944
66MP0003183_abnormal_peptide_metabolism1.36664910
67MP0001800_abnormal_humoral_immune1.35740023
68MP0003091_abnormal_cell_migration1.32972716
69MP0001853_heart_inflammation1.32920771
70MP0002085_abnormal_embryonic_tissue1.30782896
71MP0005464_abnormal_platelet_physiology1.29596266
72MP0002933_joint_inflammation1.28985283
73MP0005390_skeleton_phenotype1.25194119
74MP0000689_abnormal_spleen_morphology1.24627851
75MP0008007_abnormal_cellular_replicative1.24193999
76MP0005387_immune_system_phenotype1.24012185
77MP0001790_abnormal_immune_system1.24012185
78MP0000313_abnormal_cell_death1.22933225
79MP0001730_embryonic_growth_arrest1.22736538
80MP0002092_abnormal_eye_morphology1.22665176
81MP0002084_abnormal_developmental_patter1.21076376
82MP0002722_abnormal_immune_system1.21051646
83MP0002398_abnormal_bone_marrow1.19789178
84MP0002127_abnormal_cardiovascular_syste1.19439780
85MP0003123_paternal_imprinting1.18330705
86MP0004197_abnormal_fetal_growth/weight/1.18162586
87MP0005164_abnormal_response_to1.16223892
88MP0001873_stomach_inflammation1.15395348
89MP0005023_abnormal_wound_healing1.14170873
90MP0000685_abnormal_immune_system1.13945216
91MP0003938_abnormal_ear_development1.13392515
92MP0005166_decreased_susceptibility_to1.12609538
93MP0001348_abnormal_lacrimal_gland1.10634083
94MP0010030_abnormal_orbit_morphology1.07729543
95MP0001697_abnormal_embryo_size1.07711895
96MP0004133_heterotaxia1.04799255
97MP0000858_altered_metastatic_potential1.03879419
98MP0002080_prenatal_lethality1.03358855
99MP0003448_altered_tumor_morphology1.02046347
100MP0003436_decreased_susceptibility_to1.01686425
101MP0005266_abnormal_metabolism1.01237556
102MP0001542_abnormal_bone_strength1.00137715
103MP0005671_abnormal_response_to0.99996904
104MP0008932_abnormal_embryonic_tissue0.99930990
105MP0002932_abnormal_joint_morphology0.99841286
106* MP0002429_abnormal_blood_cell0.99641489
107* MP0002019_abnormal_tumor_incidence0.99122573
108MP0000604_amyloidosis0.99043237
109MP0002405_respiratory_system_inflammati0.98378491
110MP0004808_abnormal_hematopoietic_stem0.98375896
111MP0002132_abnormal_respiratory_system0.97684727
112MP0000703_abnormal_thymus_morphology0.97270286
113* MP0000716_abnormal_immune_system0.96455385
114MP0008058_abnormal_DNA_repair0.96197193
115MP0001958_emphysema0.95840012
116MP0003763_abnormal_thymus_physiology0.95779691
117MP0006054_spinal_hemorrhage0.95569414
118MP0008770_decreased_survivor_rate0.94904609
119MP0003828_pulmonary_edema0.94420670
120MP0003045_fibrosis0.93640265
121MP0008260_abnormal_autophagy0.93581838
122MP0005000_abnormal_immune_tolerance0.92980491
123MP0004883_abnormal_blood_vessel0.92232143
124MP0002452_abnormal_antigen_presenting0.92034913
125MP0002970_abnormal_white_adipose0.91707899
126MP0009763_increased_sensitivity_to0.91067052
127MP0000249_abnormal_blood_vessel0.90823242
128MP0002925_abnormal_cardiovascular_devel0.90459763
129MP0001663_abnormal_digestive_system0.89585224
130MP0003806_abnormal_nucleotide_metabolis0.88977648
131MP0003787_abnormal_imprinting0.88005001
132MP0002420_abnormal_adaptive_immunity0.87954993
133MP0005167_abnormal_blood-brain_barrier0.86883047
134MP0001819_abnormal_immune_cell0.86750099
135MP0000465_gastrointestinal_hemorrhage0.85474058
136MP0003119_abnormal_digestive_system0.84662888
137MP0000432_abnormal_head_morphology0.84064416
138MP0009333_abnormal_splenocyte_physiolog0.83955190
139MP0002723_abnormal_immune_serum0.83453601
140MP0003566_abnormal_cell_adhesion0.81927723
141MP0005165_increased_susceptibility_to0.80647456
142MP0003866_abnormal_defecation0.80391685
143MP0005076_abnormal_cell_differentiation0.80075654
144MP0000428_abnormal_craniofacial_morphol0.79897305
145MP0001851_eye_inflammation0.79537367
146MP0010155_abnormal_intestine_physiology0.76764417
147MP0005310_abnormal_salivary_gland0.76184277
148MP0003786_premature_aging0.75814505
149MP0002114_abnormal_axial_skeleton0.75558260
150MP0000049_abnormal_middle_ear0.75236680
151MP0002877_abnormal_melanocyte_morpholog0.75185928
152MP0001545_abnormal_hematopoietic_system0.74639569
153MP0005397_hematopoietic_system_phenotyp0.74639569
154MP0003795_abnormal_bone_structure0.74185629
155MP0000767_abnormal_smooth_muscle0.72732727
156MP0003656_abnormal_erythrocyte_physiolo0.72517366
157MP0003690_abnormal_glial_cell0.72502888
158MP0005275_abnormal_skin_tensile0.69788283
159MP0008874_decreased_physiological_sensi0.69271620
160MP0005595_abnormal_vascular_smooth0.68909754
161MP0009765_abnormal_xenobiotic_induced0.65311766

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.18996261
2Hypochromic microcytic anemia (HP:0004840)5.75931446
3Multiple enchondromatosis (HP:0005701)4.72994411
4Ependymoma (HP:0002888)4.59064952
5Myositis (HP:0100614)4.56091275
6Orchitis (HP:0100796)4.53310026
7Hepatoblastoma (HP:0002884)4.47540057
8Rib fusion (HP:0000902)4.39938491
9Retrobulbar optic neuritis (HP:0100654)4.16605408
10Optic neuritis (HP:0100653)4.16605408
11Eczematoid dermatitis (HP:0000976)4.09467398
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.96347722
13Abnormality of the lower motor neuron (HP:0002366)3.85375941
14Neoplasm of striated muscle (HP:0009728)3.77430013
15Abnormality of macrophages (HP:0004311)3.76645338
16Abnormality of glycosphingolipid metabolism (HP:0004343)3.75297651
17Abnormality of glycolipid metabolism (HP:0010969)3.75297651
18Abnormality of liposaccharide metabolism (HP:0010968)3.75297651
19Rhabdomyosarcoma (HP:0002859)3.71836278
20Recurrent bacterial skin infections (HP:0005406)3.58641501
21Chromsome breakage (HP:0040012)3.55209332
22Recurrent abscess formation (HP:0002722)3.42760779
23Systemic lupus erythematosus (HP:0002725)3.42211772
24Mediastinal lymphadenopathy (HP:0100721)3.41647474
25Increased IgE level (HP:0003212)3.38126808
26Nephroblastoma (Wilms tumor) (HP:0002667)3.37756087
27Stomatitis (HP:0010280)3.20112059
28Dysostosis multiplex (HP:0000943)3.17770012
29Astrocytoma (HP:0009592)3.12597651
30Abnormality of the astrocytes (HP:0100707)3.12597651
31Embryonal renal neoplasm (HP:0011794)3.11779955
32Keratoconjunctivitis sicca (HP:0001097)3.07655903
33Recurrent fungal infections (HP:0002841)3.07380676
34Hypochromic anemia (HP:0001931)3.07227078
35Vasculitis (HP:0002633)3.05994482
36Interstitial pulmonary disease (HP:0006530)3.02237886
37Fused cervical vertebrae (HP:0002949)3.01119467
38Loss of speech (HP:0002371)3.00325899
39Recurrent viral infections (HP:0004429)2.92340658
40Trismus (HP:0000211)2.91536931
41Pulmonary infiltrates (HP:0002113)2.91493029
42Increased cerebral lipofuscin (HP:0011813)2.87770508
43Testicular atrophy (HP:0000029)2.85686034
44Keratoconjunctivitis (HP:0001096)2.84958853
45Rectal fistula (HP:0100590)2.83871246
46Rectovaginal fistula (HP:0000143)2.83871246
47Abnormality of the salivary glands (HP:0010286)2.81351205
48Intestinal fistula (HP:0100819)2.80789704
49Abnormal delayed hypersensitivity skin test (HP:0002963)2.77365714
50Emphysema (HP:0002097)2.73348301
51Partial duplication of thumb phalanx (HP:0009944)2.72724896
52Gastrointestinal stroma tumor (HP:0100723)2.72561120
53Increased IgM level (HP:0003496)2.71799935
54Hemoptysis (HP:0002105)2.70511875
55Autoimmune thrombocytopenia (HP:0001973)2.69829685
56Nasal polyposis (HP:0100582)2.69381031
57Meningitis (HP:0001287)2.68871880
58Aplasia/hypoplasia of the humerus (HP:0006507)2.67861085
59Hypoplasia of the fovea (HP:0007750)2.67464725
60Aplasia/Hypoplasia of the fovea (HP:0008060)2.67464725
61Meckel diverticulum (HP:0002245)2.64747615
62Short humerus (HP:0005792)2.63652295
63Cellulitis (HP:0100658)2.60473562
64Hypergammaglobulinemia (HP:0010702)2.59921368
65Preauricular skin tag (HP:0000384)2.59510923
66Colitis (HP:0002583)2.57678381
67Recurrent skin infections (HP:0001581)2.56470260
68Abnormal lung lobation (HP:0002101)2.56447265
69Ragged-red muscle fibers (HP:0003200)2.56327494
70Abnormality of polysaccharide metabolism (HP:0011012)2.56005617
71Abnormality of glycosaminoglycan metabolism (HP:0004371)2.56005617
72Abnormality of mucopolysaccharide metabolism (HP:0011020)2.56005617
73Large earlobe (HP:0009748)2.55813689
74Gastrointestinal infarctions (HP:0005244)2.54985464
75Aplasia/Hypoplasia of the uvula (HP:0010293)2.53473826
76Chronic mucocutaneous candidiasis (HP:0002728)2.53256709
77Recurrent cutaneous fungal infections (HP:0011370)2.53256709
78Abnormality of the ileum (HP:0001549)2.49995351
79Increased neuronal autofluorescent lipopigment (HP:0002074)2.49417991
80Vaginal fistula (HP:0004320)2.46257410
81Gingivitis (HP:0000230)2.44520160
82Skin tags (HP:0010609)2.43535595
83Chronic obstructive pulmonary disease (HP:0006510)2.42836322
84Obstructive lung disease (HP:0006536)2.42836322
85Urinary glycosaminoglycan excretion (HP:0003541)2.42779905
86Mucopolysacchariduria (HP:0008155)2.42779905
87Amyotrophic lateral sclerosis (HP:0007354)2.42629018
88Combined immunodeficiency (HP:0005387)2.41764789
89Spontaneous hematomas (HP:0007420)2.41085301
90Abnormality of the nasal mucosa (HP:0000433)2.40266294
91Impulsivity (HP:0100710)2.38487429
92Supernumerary spleens (HP:0009799)2.37026382
93Reduced antithrombin III activity (HP:0001976)2.36363774
94Partial duplication of the phalanx of hand (HP:0009999)2.35806796
95Medulloblastoma (HP:0002885)2.35170759
96Abnormal cartilage morphology (HP:0002763)2.34292041
97Recurrent gram-negative bacterial infections (HP:0005420)2.34079833
98Encephalitis (HP:0002383)2.32661172
99Glioma (HP:0009733)2.31378120
100Cheilitis (HP:0100825)2.31155186
101Gastrointestinal inflammation (HP:0004386)2.30398554
102Vacuolated lymphocytes (HP:0001922)2.28838183
103Spondylolisthesis (HP:0003302)2.28057476
104Inflammation of the large intestine (HP:0002037)2.26468725
105Abnormality of the pericardium (HP:0001697)2.25481710
106Increased serum ferritin (HP:0003281)2.25186224
107Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.24115653
108Horizontal nystagmus (HP:0000666)2.23050642
109Pustule (HP:0200039)2.22039458
110Peritonitis (HP:0002586)2.22006380
111Hematochezia (HP:0002573)2.19187054
112Hyperinsulinemic hypoglycemia (HP:0000825)2.19127763
113Arterial thrombosis (HP:0004420)2.18048185
114Shawl scrotum (HP:0000049)2.17684709
115Urticaria (HP:0001025)2.17604573
116Petechiae (HP:0000967)2.16671495
117Thin bony cortex (HP:0002753)2.16483692
118Anomalous pulmonary venous return (HP:0010772)2.16028265
119Malnutrition (HP:0004395)2.15384956
120Polygenic inheritance (HP:0010982)2.13905357
121Myelodysplasia (HP:0002863)2.13134675
122Amyloidosis (HP:0011034)2.11838858
123Prolonged bleeding time (HP:0003010)2.10903845
124Small intestinal stenosis (HP:0012848)2.09642770
125Duodenal stenosis (HP:0100867)2.09642770
126Abnormality of the pleura (HP:0002103)2.09383319
127Gangrene (HP:0100758)2.09002655
128Protrusio acetabuli (HP:0003179)2.08472211
129Abnormality of chromosome segregation (HP:0002916)2.07797987
130Short 5th finger (HP:0009237)2.07638904
131Abnormality of small intestinal villus morphology (HP:0011472)2.07108637
132Villous atrophy (HP:0011473)2.07108637
133Restrictive lung disease (HP:0002091)2.06502555
134Pseudobulbar signs (HP:0002200)2.06171916
135Autoimmune hemolytic anemia (HP:0001890)2.03986232
136Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.03666728
137Recurrent bronchitis (HP:0002837)2.02778557
138Progressive muscle weakness (HP:0003323)2.02145609
139Neoplasm of the oral cavity (HP:0100649)2.01358198
140Purpura (HP:0000979)2.01305557
141Vertebral fusion (HP:0002948)2.00313229
142Hypertensive crisis (HP:0100735)1.99815604
143Bifid tongue (HP:0010297)1.99662889
144Nuclear cataract (HP:0100018)1.99647182
145Vertebral compression fractures (HP:0002953)1.96413269
146Tongue fasciculations (HP:0001308)1.94471439
147Elevated erythrocyte sedimentation rate (HP:0003565)1.94212755
148Agammaglobulinemia (HP:0004432)1.93919308
149Cervical subluxation (HP:0003308)1.93747768
150Chest pain (HP:0100749)1.93256088
151Abnormality of the distal phalanx of the thumb (HP:0009617)1.93173079
152Axonal loss (HP:0003447)1.92289418
153Epistaxis (HP:0000421)1.91749802
154Supernumerary ribs (HP:0005815)1.91432074
155Upper motor neuron abnormality (HP:0002127)1.90581371
156Generalized hypotonia (HP:0001290)1.89901267
157Abnormality of the preputium (HP:0100587)1.89240321
158Joint stiffness (HP:0001387)1.89044966
159Renal duplication (HP:0000075)1.88626732
160Arthralgia (HP:0002829)1.88515614
161Increased connective tissue (HP:0009025)1.87358792
162Microretrognathia (HP:0000308)1.87342847
163Hypopigmentation of the fundus (HP:0007894)1.87124392
164Abnormality of the phalanges of the hallux (HP:0010057)1.87029402
165Missing ribs (HP:0000921)1.86884644
166Abnormality of the fovea (HP:0000493)1.86512978
167Lymphopenia (HP:0001888)1.85763044
168Periauricular skin pits (HP:0100277)1.85673615
169Preauricular pit (HP:0004467)1.85673615
170Chronic otitis media (HP:0000389)1.84263613
171Glossoptosis (HP:0000162)1.84226096
172Acne (HP:0001061)1.84140969
173Abnormality of the musculature of the hand (HP:0001421)1.83740075
174Anorexia (HP:0002039)1.83203293
175Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.82962725
176Leukocytosis (HP:0001974)1.82522213
177Abnormality of iron homeostasis (HP:0011031)1.82315718
178Abnormality of cells of the lymphoid lineage (HP:0012140)1.81821616
179Atrophy/Degeneration involving motor neurons (HP:0007373)1.81388723
180Glomerulopathy (HP:0100820)1.81319027
181Malignant neoplasm of the central nervous system (HP:0100836)1.81294682
182Pendular nystagmus (HP:0012043)1.81262650
183Hand muscle atrophy (HP:0009130)1.81222487
184Atresia of the external auditory canal (HP:0000413)1.81099606
185Polycythemia (HP:0001901)1.80688896
186Keratitis (HP:0000491)1.80352740
187Aplasia/Hypoplasia of the sternum (HP:0006714)1.79976335
188Aplasia/Hypoplasia of the macula (HP:0008059)1.79641858
189Neoplasm of the heart (HP:0100544)1.79581452
190Abnormality of the pulmonary veins (HP:0011718)1.77974349
191Selective tooth agenesis (HP:0001592)1.76364847
192Supernumerary bones of the axial skeleton (HP:0009144)1.75833954
193Angiofibromas (HP:0010615)1.74452702
194Adenoma sebaceum (HP:0009720)1.74452702
195Abnormality of the duodenum (HP:0002246)1.74326793
196Volvulus (HP:0002580)1.74170339

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.45992545
2ERN14.80696776
3GRK64.07641431
4GRK53.72037756
5IRAK33.00313613
6CSF1R2.95878257
7TAOK22.89330032
8STK102.87356469
9TGFBR22.78970634
10TBK12.59793539
11PRPF4B2.56600687
12RIPK42.56259269
13TTK2.45219500
14MAP3K142.44477756
15GRK12.35178714
16ADRBK22.33913648
17MATK2.14227870
18IKBKE2.07732836
19IRAK42.05563936
20MAP3K101.97209617
21TYRO31.93120752
22CDK71.83015692
23EPHA21.77148333
24EPHB11.74394077
25GRK71.72427260
26MAP3K111.71569576
27CDC42BPA1.66398700
28MAP3K31.65120382
29JAK11.63858663
30SMG11.63095885
31MOS1.60257982
32DDR21.56323788
33MAP4K11.51169525
34WNK11.49802385
35MAP3K131.44502039
36TAOK11.39556278
37FGFR31.36181566
38PAK41.30526709
39CDC71.26401172
40PRKG21.20710675
41NEK21.20225120
42TNK21.15368568
43PLK11.13699472
44CSK1.10981188
45CAMK41.10022463
46TXK1.04042350
47ALK1.00370394
48SIK30.98730884
49MARK20.98525204
50RPS6KB20.98408325
51CDK40.95179550
52EPHA30.94485966
53MAP3K10.94378551
54IRAK10.93289651
55CHEK10.92583253
56BLK0.90241612
57BUB10.85223134
58WEE10.83385938
59FGR0.82836073
60IKBKB0.82634799
61EEF2K0.79380066
62TAOK30.79041013
63LYN0.78840356
64JAK20.78380369
65FES0.75176379
66MAP3K60.74832152
67TESK10.73809769
68BRD40.72734437
69MTOR0.72041316
70MARK30.70844601
71PDGFRA0.68900572
72MAP3K70.68733049
73TYK20.68718369
74TTN0.68025905
75ADRBK10.66853803
76JAK30.66726384
77AKT20.66686859
78MAPK110.66566755
79PIM10.64920851
80NTRK10.64538541
81TRPM70.63588463
82KIT0.63433872
83TLK10.62713224
84* HIPK20.61358296
85RPS6KA20.60969996
86STK40.60106729
87IRAK20.60001948
88RPS6KC10.59808256
89RPS6KL10.59808256
90CDK20.59498451
91MAP3K50.59096279
92FLT30.58706944
93PTK60.58576630
94EIF2AK20.57485546
95ITK0.57286032
96BMPR20.56853245
97AURKB0.55367771
98AKT30.53814667
99CHUK0.53635826
100TESK20.53003233
101PDPK10.52441614
102ATM0.51443489
103MAP2K60.51017529
104RPS6KA60.50941465
105* MAPK70.50418888
106BMX0.49008566
107ATR0.48990634
108KDR0.47274325
109MAP3K80.47197935
110DYRK30.45945498
111LMTK20.45918693
112LRRK20.45907590
113CLK10.44527952
114PRKCI0.44265900
115PDK10.42272320
116HCK0.42010911
117ZAP700.41935135
118MAPK120.41076562
119ABL20.41048364
120PKN20.39962009
121SIK20.38867347
122RIPK10.38421509
123MAP2K20.37035670
124DAPK30.36746584
125AURKA0.35481777
126LCK0.34244949
127PRKD20.33420174
128* CHEK20.33082642
129NME20.32390984
130TRIB30.31827497
131PAK10.31392358
132BTK0.31091491
133MAPKAPK30.30530547
134SYK0.29662410
135SIK10.28888377
136CDK10.28277875
137MAP2K40.27641480
138IGF1R0.27584271
139PRKCD0.27295978
140INSR0.26817311
141MAPK140.25891222
142* MAPK10.24711082
143ICK0.24481080
144MAP2K30.23348847
145PIM20.23216906
146TGFBR10.23182932
147MELK0.22854333
148FGFR40.22146419
149MAPK40.22119093
150MAPKAPK20.21994803
151CDK60.21931048
152PTK20.21882292
153SRPK10.20287677

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.98828944
2Vitamin B6 metabolism_Homo sapiens_hsa007503.80784279
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.72863119
4Allograft rejection_Homo sapiens_hsa053302.83964469
5DNA replication_Homo sapiens_hsa030302.75553101
6Fructose and mannose metabolism_Homo sapiens_hsa000512.53788820
7Osteoclast differentiation_Homo sapiens_hsa043802.46745908
8Graft-versus-host disease_Homo sapiens_hsa053322.42971738
9Mismatch repair_Homo sapiens_hsa034302.40605089
10Autoimmune thyroid disease_Homo sapiens_hsa053202.38967181
11Asthma_Homo sapiens_hsa053102.30760396
12Staphylococcus aureus infection_Homo sapiens_hsa051502.23113832
13TNF signaling pathway_Homo sapiens_hsa046682.10481446
14One carbon pool by folate_Homo sapiens_hsa006702.06787660
15RNA transport_Homo sapiens_hsa030132.06218877
16Ribosome_Homo sapiens_hsa030101.89392983
17Primary immunodeficiency_Homo sapiens_hsa053401.88195890
18Galactose metabolism_Homo sapiens_hsa000521.84999739
19Base excision repair_Homo sapiens_hsa034101.83725979
20Fanconi anemia pathway_Homo sapiens_hsa034601.82395842
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.74898522
22Tuberculosis_Homo sapiens_hsa051521.74452291
23Type I diabetes mellitus_Homo sapiens_hsa049401.74313121
24Pertussis_Homo sapiens_hsa051331.71667307
25Cell cycle_Homo sapiens_hsa041101.70692098
26Homologous recombination_Homo sapiens_hsa034401.69816938
27Rheumatoid arthritis_Homo sapiens_hsa053231.68324198
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.65846081
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.60672654
30mRNA surveillance pathway_Homo sapiens_hsa030151.59579955
31Spliceosome_Homo sapiens_hsa030401.56249439
32Arachidonic acid metabolism_Homo sapiens_hsa005901.56087332
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.52899610
34Viral myocarditis_Homo sapiens_hsa054161.52841476
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.41253757
36p53 signaling pathway_Homo sapiens_hsa041151.35918116
37Thyroid cancer_Homo sapiens_hsa052161.35470878
38B cell receptor signaling pathway_Homo sapiens_hsa046621.34950934
39mTOR signaling pathway_Homo sapiens_hsa041501.33890859
40Lysosome_Homo sapiens_hsa041421.32030274
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.26782885
42RNA degradation_Homo sapiens_hsa030181.25702197
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.24334616
44* Herpes simplex infection_Homo sapiens_hsa051681.22604635
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20037619
46Chemokine signaling pathway_Homo sapiens_hsa040621.14815437
47Pentose and glucuronate interconversions_Homo sapiens_hsa000401.14388564
48Salmonella infection_Homo sapiens_hsa051321.14284530
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12076921
50* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.09854210
51Other glycan degradation_Homo sapiens_hsa005111.09636406
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08873153
53Linoleic acid metabolism_Homo sapiens_hsa005911.08460570
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07847386
55Nucleotide excision repair_Homo sapiens_hsa034201.03788395
56MicroRNAs in cancer_Homo sapiens_hsa052061.03397672
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02706007
58Intestinal immune network for IgA production_Homo sapiens_hsa046721.02367545
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.01538457
60Non-homologous end-joining_Homo sapiens_hsa034501.01461071
61Apoptosis_Homo sapiens_hsa042100.97639566
62Antigen processing and presentation_Homo sapiens_hsa046120.96472794
63Shigellosis_Homo sapiens_hsa051310.96354839
64Leishmaniasis_Homo sapiens_hsa051400.96132363
65Amoebiasis_Homo sapiens_hsa051460.95937116
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93268279
67Notch signaling pathway_Homo sapiens_hsa043300.93073704
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.92220511
69Phagosome_Homo sapiens_hsa041450.91477553
70Measles_Homo sapiens_hsa051620.89975768
71Prolactin signaling pathway_Homo sapiens_hsa049170.86847203
72Viral carcinogenesis_Homo sapiens_hsa052030.83148256
73Hematopoietic cell lineage_Homo sapiens_hsa046400.82926670
74HTLV-I infection_Homo sapiens_hsa051660.81717535
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.80169715
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.79416005
77Non-small cell lung cancer_Homo sapiens_hsa052230.78064242
78T cell receptor signaling pathway_Homo sapiens_hsa046600.75614124
79RNA polymerase_Homo sapiens_hsa030200.73905324
80Pentose phosphate pathway_Homo sapiens_hsa000300.73883888
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73430190
82Small cell lung cancer_Homo sapiens_hsa052220.72612972
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72389688
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.71999174
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.71622906
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71054482
87Pyrimidine metabolism_Homo sapiens_hsa002400.70953667
88Prion diseases_Homo sapiens_hsa050200.69372610
89Inositol phosphate metabolism_Homo sapiens_hsa005620.67718204
90* Pathways in cancer_Homo sapiens_hsa052000.65463360
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.61595413
92African trypanosomiasis_Homo sapiens_hsa051430.60794003
93Pancreatic cancer_Homo sapiens_hsa052120.60665924
94Bladder cancer_Homo sapiens_hsa052190.60592223
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58766495
96Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58374662
97Sulfur relay system_Homo sapiens_hsa041220.57814104
98Basal transcription factors_Homo sapiens_hsa030220.57431806
99* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56283957
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55924404
101Basal cell carcinoma_Homo sapiens_hsa052170.55727232
102Platelet activation_Homo sapiens_hsa046110.54482773
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.54134227
104* Influenza A_Homo sapiens_hsa051640.53487405
105Folate biosynthesis_Homo sapiens_hsa007900.53479269
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52877005
107* Acute myeloid leukemia_Homo sapiens_hsa052210.52482996
108Legionellosis_Homo sapiens_hsa051340.52443727
109Lysine degradation_Homo sapiens_hsa003100.52193131
110Insulin resistance_Homo sapiens_hsa049310.52003041
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50149775
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49665666
113Chronic myeloid leukemia_Homo sapiens_hsa052200.49439068
114Epstein-Barr virus infection_Homo sapiens_hsa051690.48963421
115Toxoplasmosis_Homo sapiens_hsa051450.48372225
116Proteoglycans in cancer_Homo sapiens_hsa052050.48130053
117Systemic lupus erythematosus_Homo sapiens_hsa053220.47531234
118Hepatitis B_Homo sapiens_hsa051610.47068737
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45827002
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.44981330
121Hepatitis C_Homo sapiens_hsa051600.44941581
122Colorectal cancer_Homo sapiens_hsa052100.43394535
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42211951
124VEGF signaling pathway_Homo sapiens_hsa043700.40280843
125Choline metabolism in cancer_Homo sapiens_hsa052310.39854471
126Rap1 signaling pathway_Homo sapiens_hsa040150.39393363
127Selenocompound metabolism_Homo sapiens_hsa004500.39351363
128Malaria_Homo sapiens_hsa051440.38733419
129Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38508150
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38470353
131MAPK signaling pathway_Homo sapiens_hsa040100.38408550
132Renal cell carcinoma_Homo sapiens_hsa052110.37993370
133* Endocytosis_Homo sapiens_hsa041440.37717296
134Focal adhesion_Homo sapiens_hsa045100.37319243
135GnRH signaling pathway_Homo sapiens_hsa049120.37229704
136Toll-like receptor signaling pathway_Homo sapiens_hsa046200.36922588
137Dorso-ventral axis formation_Homo sapiens_hsa043200.36347434
138SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35675598
139Chemical carcinogenesis_Homo sapiens_hsa052040.35493366
140Type II diabetes mellitus_Homo sapiens_hsa049300.35370182
141Adherens junction_Homo sapiens_hsa045200.34723768
142Complement and coagulation cascades_Homo sapiens_hsa046100.33356374
143HIF-1 signaling pathway_Homo sapiens_hsa040660.32588019
144Hippo signaling pathway_Homo sapiens_hsa043900.31635364
145FoxO signaling pathway_Homo sapiens_hsa040680.29155279
146Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26870255
147Prostate cancer_Homo sapiens_hsa052150.26489865
148Sphingolipid metabolism_Homo sapiens_hsa006000.23315938

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