PMP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene localizes to myelin sheaths of the peripheral nervous system. The encoded protein can bind both the membrane layers of the sheaths and monomeric lipids, and is thought to provide stability to the sheath. A defect in this gene was shown to be a cause of dominant demyelinating CMT neuropathy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1myelination in peripheral nervous system (GO:0022011)9.19146067
2peripheral nervous system axon ensheathment (GO:0032292)9.19146067
3cellular component maintenance (GO:0043954)7.84922731
4axon ensheathment (GO:0008366)7.53451699
5ensheathment of neurons (GO:0007272)7.53451699
6postsynaptic membrane organization (GO:0001941)7.39317089
7myelin assembly (GO:0032288)7.05607835
8hemidesmosome assembly (GO:0031581)6.93548849
9axon ensheathment in central nervous system (GO:0032291)6.83917039
10central nervous system myelination (GO:0022010)6.83917039
11regulation of pigment cell differentiation (GO:0050932)6.63479156
12peptidyl-tyrosine autophosphorylation (GO:0038083)6.47408415
13L-amino acid import (GO:0043092)6.43091607
14peripheral nervous system development (GO:0007422)6.09622523
15presynaptic membrane assembly (GO:0097105)6.08872376
16cellular potassium ion homeostasis (GO:0030007)5.95600251
17neuron cell-cell adhesion (GO:0007158)5.87617044
18Leydig cell differentiation (GO:0033327)5.83003563
19amino acid import (GO:0043090)5.78140320
20positive regulation of developmental pigmentation (GO:0048087)5.61712693
21myelination (GO:0042552)5.61164893
22presynaptic membrane organization (GO:0097090)5.55069212
23positive regulation of neurological system process (GO:0031646)5.47854993
24sodium ion export (GO:0071436)5.44449792
25cell adhesion mediated by integrin (GO:0033627)5.43018603
26astrocyte differentiation (GO:0048708)5.34402133
27potassium ion import (GO:0010107)5.31396668
28locomotory exploration behavior (GO:0035641)5.29902550
29dermatan sulfate biosynthetic process (GO:0030208)5.19015915
30male sex determination (GO:0030238)5.07466890
31neurotransmitter uptake (GO:0001504)5.06416986
32potassium ion homeostasis (GO:0055075)4.95133470
33basement membrane organization (GO:0071711)4.92486831
34dermatan sulfate metabolic process (GO:0030205)4.80638886
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.66754250
36chondroitin sulfate catabolic process (GO:0030207)4.50638148
37regulation of synapse structural plasticity (GO:0051823)4.48508793
38cytoskeletal anchoring at plasma membrane (GO:0007016)4.46422589
39myelin maintenance (GO:0043217)4.43227855
40auditory behavior (GO:0031223)4.42387146
41neurotransmitter-gated ion channel clustering (GO:0072578)4.38580943
42astrocyte development (GO:0014002)4.37837909
43positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.37216370
44vocalization behavior (GO:0071625)4.36364125
45ionotropic glutamate receptor signaling pathway (GO:0035235)4.35208062
46calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.28694961
47regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.26551372
48extracellular fibril organization (GO:0043206)4.25128726
49proline transport (GO:0015824)4.20301905
50positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.17653276
51cerebellar granule cell differentiation (GO:0021707)4.16133735
52regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.15519833
53mechanosensory behavior (GO:0007638)4.14092258
54synaptic vesicle maturation (GO:0016188)4.12255182
55exploration behavior (GO:0035640)4.07578961
56collagen fibril organization (GO:0030199)4.04404511
57synaptic vesicle docking involved in exocytosis (GO:0016081)4.01199618
58positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.98974776
59synaptic vesicle exocytosis (GO:0016079)3.97704813
60acidic amino acid transport (GO:0015800)3.91102764
61oligodendrocyte differentiation (GO:0048709)3.89605568
62glutamate secretion (GO:0014047)3.87750246
63cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.87677720
64cellular sodium ion homeostasis (GO:0006883)3.87511519
65response to auditory stimulus (GO:0010996)3.85624247
66regulation of synaptic vesicle exocytosis (GO:2000300)3.84467591
67eye photoreceptor cell differentiation (GO:0001754)3.75437207
68photoreceptor cell differentiation (GO:0046530)3.75437207
69skin development (GO:0043588)3.73925141
70positive regulation of Rho protein signal transduction (GO:0035025)3.67500392
71collagen catabolic process (GO:0030574)3.66112623
72fibril organization (GO:0097435)3.64588259
73one-carbon compound transport (GO:0019755)3.63307012
74negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.62909163
75renal system development (GO:0072001)3.59656337
76regulation of neurotransmitter uptake (GO:0051580)3.57778488
77gamma-aminobutyric acid transport (GO:0015812)3.57169997
78synaptic transmission, glutamatergic (GO:0035249)3.55646044
79negative regulation of synaptic transmission, GABAergic (GO:0032229)3.55601433
80collagen metabolic process (GO:0032963)3.51952646
81long-term synaptic potentiation (GO:0060291)3.49408403
82negative regulation of bone resorption (GO:0045779)3.49047509
83C4-dicarboxylate transport (GO:0015740)3.48487458
84regulation of beta-amyloid formation (GO:1902003)3.47780996
85L-glutamate transport (GO:0015813)3.46707813
86protein heterotrimerization (GO:0070208)3.44566667
87regulation of neuronal synaptic plasticity (GO:0048168)3.43702045
88cranial nerve structural organization (GO:0021604)3.43202911
89cell communication by electrical coupling (GO:0010644)3.41244605
90extracellular matrix disassembly (GO:0022617)3.39302952
91endodermal cell differentiation (GO:0035987)3.38723313
92regulation of respiratory system process (GO:0044065)3.36023335
93multicellular organismal macromolecule metabolic process (GO:0044259)3.35053821
94regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.35036002
95multicellular organismal catabolic process (GO:0044243)3.33579863
96regulation of synaptic vesicle transport (GO:1902803)3.32900358
97regulation of glutamate receptor signaling pathway (GO:1900449)3.32577745
98membrane assembly (GO:0071709)3.32424338
99cell-substrate junction assembly (GO:0007044)3.32370119
100neurotransmitter secretion (GO:0007269)3.31864918
101regulation of inclusion body assembly (GO:0090083)3.30292227
102negative regulation of neurotransmitter transport (GO:0051589)3.29278321
103glial cell proliferation (GO:0014009)3.27399148
104regulation of synaptic transmission, glutamatergic (GO:0051966)3.26755088
105hyperosmotic salinity response (GO:0042538)3.26503758
106alanine transport (GO:0032328)3.25993341
107glutamate receptor signaling pathway (GO:0007215)3.21169720
108regulation of short-term neuronal synaptic plasticity (GO:0048172)3.19019046
109regulation of myelination (GO:0031641)3.18009938
110protein localization to synapse (GO:0035418)3.16495820
111signal complex assembly (GO:0007172)3.15438019
112growth hormone receptor signaling pathway (GO:0060396)3.14020471
113multicellular organismal metabolic process (GO:0044236)3.14018777
114neuromuscular process controlling balance (GO:0050885)3.11839281
115regulation of developmental pigmentation (GO:0048070)3.10415580
116regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.09402304
117positive regulation of p38MAPK cascade (GO:1900745)3.09133395
118bundle of His cell to Purkinje myocyte communication (GO:0086069)3.08730265
119negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.05647857
120fatty acid elongation (GO:0030497)3.05130518
121regulation of cardiac muscle cell contraction (GO:0086004)3.04798317
122cell-matrix adhesion (GO:0007160)3.03795631
123semaphorin-plexin signaling pathway (GO:0071526)3.00912583
124neuron-neuron synaptic transmission (GO:0007270)3.00456488
125positive regulation of potassium ion transmembrane transport (GO:1901381)2.98627659
126regulation of long-term neuronal synaptic plasticity (GO:0048169)2.98480491
127negative regulation of bone remodeling (GO:0046851)2.98031463
128neurotransmitter transport (GO:0006836)2.96968884
129surfactant homeostasis (GO:0043129)2.95652727
130transmission of nerve impulse (GO:0019226)2.95410028
131glial cell differentiation (GO:0010001)2.95152008
132positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.94680914
133cGMP-mediated signaling (GO:0019934)2.92747609
134positive regulation of T cell migration (GO:2000406)2.92720035
135regulation of neurotransmitter levels (GO:0001505)2.91554707
136positive regulation of synapse maturation (GO:0090129)2.90425945
137regulation of neurotransmitter transport (GO:0051588)2.90335595
138establishment of mitochondrion localization (GO:0051654)2.89584261
139cerebellar Purkinje cell layer development (GO:0021680)2.87736212
140negative regulation of neurotransmitter secretion (GO:0046929)2.87434839
141actin filament depolymerization (GO:0030042)2.80947738
142cellular response to cholesterol (GO:0071397)2.80849528
143regulation of synaptic plasticity (GO:0048167)2.80158002
144startle response (GO:0001964)2.80089214
145negative regulation of smooth muscle cell migration (GO:0014912)2.79952764
146membrane hyperpolarization (GO:0060081)2.78995798
147synapse assembly (GO:0007416)2.77903408
148negative regulation of cytosolic calcium ion concentration (GO:0051481)2.77270965
149negative regulation of inclusion body assembly (GO:0090084)2.77115506
150anatomical structure arrangement (GO:0048532)2.74082820
151regulation of sodium ion transmembrane transporter activity (GO:2000649)2.71582043
152cell junction organization (GO:0034330)2.70808228
153extracellular matrix organization (GO:0030198)2.69124678
154extracellular structure organization (GO:0043062)2.68033830
155regulation of neuron migration (GO:2001222)2.67354467
156cortical actin cytoskeleton organization (GO:0030866)2.66249958
157substrate adhesion-dependent cell spreading (GO:0034446)2.64242063
158cell-substrate adhesion (GO:0031589)2.63946231
159response to lipoprotein particle (GO:0055094)2.61536300
160filopodium assembly (GO:0046847)2.61500146
161cellular response to growth hormone stimulus (GO:0071378)2.61236144
162glycine transport (GO:0015816)2.58997105
163integrin-mediated signaling pathway (GO:0007229)2.58869582
164positive regulation of smooth muscle cell migration (GO:0014911)2.57351153
165cholesterol biosynthetic process (GO:0006695)2.52981348
166regulation of T cell migration (GO:2000404)2.52772089
167response to prostaglandin E (GO:0034695)2.52763080
168negative regulation of tissue remodeling (GO:0034104)2.50312602
169neuronal ion channel clustering (GO:0045161)2.49951249
170cell-cell junction organization (GO:0045216)2.48240958
171cell migration in hindbrain (GO:0021535)2.47420439
172Rho protein signal transduction (GO:0007266)2.45825118
173heterotypic cell-cell adhesion (GO:0034113)2.45401392
174layer formation in cerebral cortex (GO:0021819)2.42644953
175long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.39278833
176endocardial cushion development (GO:0003197)2.38921993
177regulation of fever generation (GO:0031620)2.37435420
178sex determination (GO:0007530)2.37064728
179glial cell migration (GO:0008347)2.35515558
180positive regulation of lymphocyte migration (GO:2000403)2.34038015
181phagocytosis, engulfment (GO:0006911)2.33391577
182response to magnesium ion (GO:0032026)2.32515267
183L-serine transport (GO:0015825)2.32282072
184regulation of Rac protein signal transduction (GO:0035020)2.29922931
185neuron projection regeneration (GO:0031102)2.29882353
186detection of temperature stimulus (GO:0016048)2.29152814
187positive regulation of protein tyrosine kinase activity (GO:0061098)2.27871728
188cortical cytoskeleton organization (GO:0030865)2.27199091
189regulation of heat generation (GO:0031650)2.25258819
190chemical homeostasis within a tissue (GO:0048875)2.24337697
191negative regulation of axon extension (GO:0030517)2.23889552
192cell-cell junction maintenance (GO:0045217)16.9899724
193cell junction maintenance (GO:0034331)13.6163755
194neuronal action potential propagation (GO:0019227)12.7470958

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.91823528
2ZNF263_19887448_ChIP-Seq_K562_Human4.84051569
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.11914858
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.59857549
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.42849534
6CDX2_19796622_ChIP-Seq_MESCs_Mouse3.05411024
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.83460287
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.70814097
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.62513492
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.58127797
11REST_21632747_ChIP-Seq_MESCs_Mouse2.54539761
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.42623734
13RNF2_27304074_Chip-Seq_ESCs_Mouse2.37390244
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.34432710
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.34132634
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.30584685
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.22993579
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.22709049
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.22040640
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.15672086
21GATA1_22025678_ChIP-Seq_K562_Human1.98227429
22REST_18959480_ChIP-ChIP_MESCs_Mouse1.95808087
23TP53_16413492_ChIP-PET_HCT116_Human1.94723740
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.92451703
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.89557285
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.88127863
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.88097676
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83683027
29EP300_21415370_ChIP-Seq_HL-1_Mouse1.80016098
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.76561982
31GATA2_21666600_ChIP-Seq_HMVEC_Human1.73583966
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.70244652
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.70244652
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.68001650
35CLOCK_20551151_ChIP-Seq_293T_Human1.63535801
36RING1B_27294783_Chip-Seq_ESCs_Mouse1.62608881
37* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.54693366
38AHR_22903824_ChIP-Seq_MCF-7_Human1.52731495
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51733288
40SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.48923988
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48814783
42RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.48138104
43* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45229772
44SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.44573718
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.43983807
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43549196
47EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.42830958
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42460049
49CJUN_26792858_Chip-Seq_BT549_Human1.40382900
50DROSHA_22980978_ChIP-Seq_HELA_Human1.37527955
51GATA1_19941826_ChIP-Seq_K562_Human1.36265152
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36263219
53GBX2_23144817_ChIP-Seq_PC3_Human1.35427125
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34992679
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34915033
56AR_21572438_ChIP-Seq_LNCaP_Human1.33951959
57RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.32035180
58CTNNB1_20460455_ChIP-Seq_HCT116_Human1.31463539
59SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.30392656
60SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28520661
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28270842
62RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.27825974
63PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.27305623
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26730928
65SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.26591513
66TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26041339
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25177401
68SOX2_21211035_ChIP-Seq_LN229_Gbm1.23547448
69CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.23503235
70MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.23109374
71PPAR_26484153_Chip-Seq_NCI-H1993_Human1.21390884
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20495653
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.19784391
74PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19197368
75EED_16625203_ChIP-ChIP_MESCs_Mouse1.18837514
76SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.16794127
77WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16768541
78YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16543283
79HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16111827
80KDM2B_26808549_Chip-Seq_K562_Human1.15563731
81JARID2_20064375_ChIP-Seq_MESCs_Mouse1.15495057
82WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15466735
83NRF2_20460467_ChIP-Seq_MEFs_Mouse1.14732162
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.14732162
85AR_21909140_ChIP-Seq_LNCAP_Human1.14539957
86ELK3_25401928_ChIP-Seq_HUVEC_Human1.13986039
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13288010
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.12803608
89CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12534220
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.12023643
91EZH2_27294783_Chip-Seq_ESCs_Mouse1.11477503
92SMAD4_21799915_ChIP-Seq_A2780_Human1.11200728
93ESR1_21235772_ChIP-Seq_MCF-7_Human1.11062776
94ERG_21242973_ChIP-ChIP_JURKAT_Human1.11017289
95FOXO3_23340844_ChIP-Seq_DLD1_Human1.10834638
96SOX2_20726797_ChIP-Seq_SW620_Human1.10715274
97RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09701904
98OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.08576396
99TP53_18474530_ChIP-ChIP_U2OS_Human1.08521803
100RING1B_27294783_Chip-Seq_NPCs_Mouse1.08286699
101DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06786001
102EZH2_27304074_Chip-Seq_ESCs_Mouse1.06223630
103ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06075748
104GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05882022
105SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05757998
106TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04126065
107SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03720177
108CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02705307
109PIAS1_25552417_ChIP-Seq_VCAP_Human1.02353956
110KDM2B_26808549_Chip-Seq_DND41_Human1.02240648
111SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02089641
112LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00321079
113SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99990639
114SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99990639
115ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99209043
116ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98496611
117GATA1_26923725_Chip-Seq_HPCs_Mouse0.97676775
118NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97043131
119* LXR_22158963_ChIP-Seq_LIVER_Mouse0.95954309
120AR_19668381_ChIP-Seq_PC3_Human0.95296344
121JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94999597
122TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94973408
123PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94641161
124SMAD3_21741376_ChIP-Seq_ESCs_Human0.94628257
125KDM2B_26808549_Chip-Seq_JURKAT_Human0.93355910
126JARID2_20075857_ChIP-Seq_MESCs_Mouse0.93164010
127TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93102100
128P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93078999
129IGF1R_20145208_ChIP-Seq_DFB_Human0.92777868
130STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92560486
131GATA2_19941826_ChIP-Seq_K562_Human0.92409658
132JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91524760
133TCF4_18268006_ChIP-ChIP_LS174T_Human0.90070668
134TCF4_23295773_ChIP-Seq_U87_Human0.90023397
135TP63_23658742_ChIP-Seq_EP156T_Human0.89868555
136* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89621563
137EGR1_19032775_ChIP-ChIP_M12_Human0.89548219
138NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89376882
139SUZ12_27294783_Chip-Seq_ESCs_Mouse0.89360311
140P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88950075
141P300_19829295_ChIP-Seq_ESCs_Human0.88751675
142SOX9_26525672_Chip-Seq_HEART_Mouse0.88738135
143MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88634471
144STAT3_23295773_ChIP-Seq_U87_Human0.88097752
145NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.87974602
146FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87906368
147TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87394543
148WT1_19549856_ChIP-ChIP_CCG9911_Human0.87382705
149ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87061141
150RNF2_27304074_Chip-Seq_NSC_Mouse0.86720234
151SMAD4_21741376_ChIP-Seq_HESCs_Human0.85680741
152EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.85463848
153KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.85209518
154JUN_21703547_ChIP-Seq_K562_Human0.84944970

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004272_abnormal_basement_membrane6.84578603
2MP0008260_abnormal_autophagy5.61453638
3MP0000920_abnormal_myelination5.27046859
4MP0008438_abnormal_cutaneous_collagen5.18897731
5MP0003136_yellow_coat_color4.82901727
6MP0001968_abnormal_touch/_nociception4.24197864
7MP0005423_abnormal_somatic_nervous3.78903171
8MP0003045_fibrosis3.64326172
9MP0003880_abnormal_central_pattern3.59341485
10MP0000751_myopathy3.38832962
11MP0000749_muscle_degeneration3.22354871
12MP0001486_abnormal_startle_reflex3.22154989
13MP0003634_abnormal_glial_cell3.18566454
14MP0004885_abnormal_endolymph3.15213413
15MP0005275_abnormal_skin_tensile3.08272573
16MP0005623_abnormal_meninges_morphology3.04406234
17MP0000747_muscle_weakness2.94286476
18MP0009745_abnormal_behavioral_response2.77888599
19MP0002063_abnormal_learning/memory/cond2.74008174
20MP0001984_abnormal_olfaction2.52859668
21MP0005167_abnormal_blood-brain_barrier2.51018275
22MP0004381_abnormal_hair_follicle2.38036248
23MP0003315_abnormal_perineum_morphology2.34657347
24MP0004858_abnormal_nervous_system2.33252777
25MP0002572_abnormal_emotion/affect_behav2.30371376
26MP0001661_extended_life_span2.21377813
27MP0002734_abnormal_mechanical_nocicepti2.20657206
28MP0000013_abnormal_adipose_tissue2.18420506
29MP0005503_abnormal_tendon_morphology2.13254012
30MP0005646_abnormal_pituitary_gland2.08774362
31MP0002272_abnormal_nervous_system2.05651857
32MP0001502_abnormal_circadian_rhythm2.02952267
33MP0009780_abnormal_chondrocyte_physiolo1.89099016
34MP0003632_abnormal_nervous_system1.88830765
35MP0004782_abnormal_surfactant_physiolog1.88504668
36MP0002938_white_spotting1.81823320
37MP0009384_cardiac_valve_regurgitation1.80069645
38MP0003329_amyloid_beta_deposits1.68937763
39MP0002653_abnormal_ependyma_morphology1.67553953
40MP0001905_abnormal_dopamine_level1.63539446
41MP0002067_abnormal_sensory_capabilities1.62217703
42MP0001501_abnormal_sleep_pattern1.61464568
43MP0004145_abnormal_muscle_electrophysio1.60520779
44MP0000955_abnormal_spinal_cord1.60484193
45MP0002733_abnormal_thermal_nociception1.59647782
46MP0003631_nervous_system_phenotype1.57345073
47MP0000750_abnormal_muscle_regeneration1.55227751
48MP0001299_abnormal_eye_distance/1.50660471
49MP0005075_abnormal_melanosome_morpholog1.49439955
50MP0005171_absent_coat_pigmentation1.45910523
51MP0001485_abnormal_pinna_reflex1.44475520
52MP0008569_lethality_at_weaning1.44100521
53MP0003950_abnormal_plasma_membrane1.43066185
54MP0001177_atelectasis1.41100879
55MP0005551_abnormal_eye_electrophysiolog1.39590563
56MP0004742_abnormal_vestibular_system1.38070539
57MP0000604_amyloidosis1.36277783
58MP0002168_other_aberrant_phenotype1.36084114
59MP0004270_analgesia1.33474788
60MP0001963_abnormal_hearing_physiology1.30524391
61MP0006276_abnormal_autonomic_nervous1.30171506
62MP0003879_abnormal_hair_cell1.28286409
63MP0004134_abnormal_chest_morphology1.28164219
64MP0003633_abnormal_nervous_system1.26832630
65MP0002108_abnormal_muscle_morphology1.22796611
66MP0001529_abnormal_vocalization1.21248472
67MP0003075_altered_response_to1.20790721
68MP0001440_abnormal_grooming_behavior1.20754043
69MP0005408_hypopigmentation1.20338682
70MP0002152_abnormal_brain_morphology1.16629635
71MP0002909_abnormal_adrenal_gland1.14154974
72MP0004142_abnormal_muscle_tone1.13091528
73MP0002638_abnormal_pupillary_reflex1.11591467
74MP0001986_abnormal_taste_sensitivity1.07655526
75MP0009379_abnormal_foot_pigmentation1.07202400
76MP0000026_abnormal_inner_ear1.06811341
77MP0005253_abnormal_eye_physiology1.06555733
78MP0000579_abnormal_nail_morphology1.04093042
79MP0005386_behavior/neurological_phenoty1.02582692
80MP0004924_abnormal_behavior1.02582692
81MP0002089_abnormal_postnatal_growth/wei1.01199308
82MP0002736_abnormal_nociception_after0.97760109
83MP0010771_integument_phenotype0.93968116
84MP0001958_emphysema0.93919378
85MP0001542_abnormal_bone_strength0.92737712
86MP0009046_muscle_twitch0.90229249
87MP0003279_aneurysm0.88957534
88MP0002822_catalepsy0.88760350
89MP0001970_abnormal_pain_threshold0.88558628
90MP0002269_muscular_atrophy0.87943013
91MP0002060_abnormal_skin_morphology0.79584336
92MP0002184_abnormal_innervation0.79246768
93MP0002752_abnormal_somatic_nervous0.79166400
94MP0004043_abnormal_pH_regulation0.76160753
95MP0003183_abnormal_peptide_metabolism0.75649398
96MP0000569_abnormal_digit_pigmentation0.74977244
97MP0003705_abnormal_hypodermis_morpholog0.74518849
98MP0003283_abnormal_digestive_organ0.72420536
99MP0002896_abnormal_bone_mineralization0.71130177
100MP0003787_abnormal_imprinting0.70826515
101MP0003137_abnormal_impulse_conducting0.70561281
102MP0002877_abnormal_melanocyte_morpholog0.68767968
103MP0005595_abnormal_vascular_smooth0.68573691
104MP0003690_abnormal_glial_cell0.68369972
105MP0000778_abnormal_nervous_system0.67719626
106MP0002069_abnormal_eating/drinking_beha0.65800476
107MP0000462_abnormal_digestive_system0.65537851
108MP0001915_intracranial_hemorrhage0.65513355
109MP0000631_abnormal_neuroendocrine_gland0.65218175
110MP0002229_neurodegeneration0.64442905
111MP0003385_abnormal_body_wall0.64090769
112MP0000003_abnormal_adipose_tissue0.63309106
113MP0004130_abnormal_muscle_cell0.62469547
114MP0002751_abnormal_autonomic_nervous0.59973334
115MP0004087_abnormal_muscle_fiber0.59189128
116MP0001348_abnormal_lacrimal_gland0.58939548
117MP0003861_abnormal_nervous_system0.58355577
118MP0000733_abnormal_muscle_development0.57989381
119MP0003172_abnormal_lysosome_physiology0.57480754
120MP0004859_abnormal_synaptic_plasticity0.57429949
121MP0002249_abnormal_larynx_morphology0.56923218
122MP0005330_cardiomyopathy0.56485783
123MP0008874_decreased_physiological_sensi0.55836999
124MP0003566_abnormal_cell_adhesion0.55465716
125MP0005166_decreased_susceptibility_to0.55296411
126MP0002106_abnormal_muscle_physiology0.54741170
127MP0002133_abnormal_respiratory_system0.54590827
128MP0005388_respiratory_system_phenotype0.54590827
129MP0004215_abnormal_myocardial_fiber0.52498314
130MP0010769_abnormal_survival0.52206181
131MP0004811_abnormal_neuron_physiology0.51078005
132MP0001849_ear_inflammation0.50892089
133MP0000639_abnormal_adrenal_gland0.50388550
134MP0000685_abnormal_immune_system0.49344839
135MP0002082_postnatal_lethality0.48587375
136MP0010770_preweaning_lethality0.48587375
137MP0010768_mortality/aging0.48031531
138MP0001270_distended_abdomen0.47300494
139MP0000566_synostosis0.47123340
140MP0002138_abnormal_hepatobiliary_system0.46667611
141MP0005195_abnormal_posterior_eye0.46478043
142MP0002735_abnormal_chemical_nociception0.46138719
143MP0004510_myositis0.46125524
144MP0005535_abnormal_body_temperature0.45120276
145MP0005369_muscle_phenotype0.43943492
146MP0002066_abnormal_motor_capabilities/c0.43577788
147MP0001186_pigmentation_phenotype0.43558545
148MP0002095_abnormal_skin_pigmentation0.42401587
149MP0003303_peritoneal_inflammation0.41977037
150MP0002882_abnormal_neuron_morphology0.41060497
151MP0003091_abnormal_cell_migration0.40668231
152MP0004233_abnormal_muscle_weight0.39451799
153MP0002837_dystrophic_cardiac_calcinosis0.38390025
154MP0009250_abnormal_appendicular_skeleto0.37638083
155MP0003635_abnormal_synaptic_transmissio0.37056965
156MP0002139_abnormal_hepatobiliary_system0.37028084
157MP0003300_gastrointestinal_ulcer0.36194654
158MP0002557_abnormal_social/conspecific_i0.35321463
159MP0005508_abnormal_skeleton_morphology0.34878912
160MP0002064_seizures0.34627996
161MP0002075_abnormal_coat/hair_pigmentati0.34187768
162MP0001943_abnormal_respiration0.33701519
163MP0000762_abnormal_tongue_morphology0.33017649
164MP0005083_abnormal_biliary_tract0.32839240

Predicted human phenotypes

RankGene SetZ-score
1Action tremor (HP:0002345)9.08544334
2Increased CSF protein (HP:0002922)7.88508382
3Upper limb muscle weakness (HP:0003484)6.74055399
4Peripheral hypomyelination (HP:0007182)6.73704846
5Onion bulb formation (HP:0003383)6.25463036
6Steppage gait (HP:0003376)6.20101269
7Focal motor seizures (HP:0011153)5.53961591
8Abnormal pupillary function (HP:0007686)5.48338543
9Abnormality of the vocal cords (HP:0008777)5.43029643
10Hammertoe (HP:0001765)5.38982420
11Decreased number of peripheral myelinated nerve fibers (HP:0003380)5.37684448
12Postural tremor (HP:0002174)5.36916426
13Decreased number of large peripheral myelinated nerve fibers (HP:0003387)5.25084449
14Foot dorsiflexor weakness (HP:0009027)5.12867172
15Neurofibrillary tangles (HP:0002185)4.97712130
16Peripheral demyelination (HP:0011096)4.97596227
17Myokymia (HP:0002411)4.88029899
18Decreased motor nerve conduction velocity (HP:0003431)4.79448828
19Diplopia (HP:0000651)4.79358180
20Abnormality of binocular vision (HP:0011514)4.79358180
21Abnormality of the foot musculature (HP:0001436)4.74255762
22Megalencephaly (HP:0001355)4.56929091
23Hemiplegia (HP:0002301)4.46179361
24Hemiparesis (HP:0001269)4.43518457
25Increased circulating renin level (HP:0000848)4.20429195
26Progressive sensorineural hearing impairment (HP:0000408)4.17319809
27Focal seizures (HP:0007359)4.10892364
28Split foot (HP:0001839)3.88610836
29Abnormal eating behavior (HP:0100738)3.51568765
30Cerebral inclusion bodies (HP:0100314)3.49951577
31Febrile seizures (HP:0002373)3.48496631
32Ankle clonus (HP:0011448)3.47865357
33Generalized tonic-clonic seizures (HP:0002069)3.41565024
34Atonic seizures (HP:0010819)3.40799976
35Epileptic encephalopathy (HP:0200134)3.38326982
36Supranuclear gaze palsy (HP:0000605)3.30273474
37Intention tremor (HP:0002080)3.29593849
38Dysdiadochokinesis (HP:0002075)3.18912687
39Morphological abnormality of the inner ear (HP:0011390)3.16034253
40Obstructive sleep apnea (HP:0002870)3.15188494
41Truncal ataxia (HP:0002078)3.04369644
42Spastic gait (HP:0002064)3.03535256
43Atrophic scars (HP:0001075)3.01234328
44Progressive hearing impairment (HP:0001730)2.92245470
45Scanning speech (HP:0002168)2.88437439
46Abnormality of proline metabolism (HP:0010907)2.83219288
47Hydroxyprolinuria (HP:0003080)2.83219288
48Abnormality of the diencephalon (HP:0010662)2.82670297
49Hyperventilation (HP:0002883)2.79130686
50Degeneration of the lateral corticospinal tracts (HP:0002314)2.75384398
51Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.75384398
52Anomalous pulmonary venous return (HP:0010772)2.67332154
53Distal sensory impairment (HP:0002936)2.63581024
54Absence seizures (HP:0002121)2.62700294
55Metabolic alkalosis (HP:0200114)2.56340602
56Dialeptic seizures (HP:0011146)2.56126331
57Abnormality of the corticospinal tract (HP:0002492)2.51521296
58Progressive cerebellar ataxia (HP:0002073)2.50499196
59Aplasia involving bones of the upper limbs (HP:0009823)2.50001421
60Aplasia of the phalanges of the hand (HP:0009802)2.50001421
61Aplasia involving bones of the extremities (HP:0009825)2.50001421
62Hypomagnesemia (HP:0002917)2.49985908
63Dysmetria (HP:0001310)2.46583118
64Abnormality of cochlea (HP:0000375)2.45824671
65Insomnia (HP:0100785)2.45059957
66Postural instability (HP:0002172)2.44744350
67Limb dystonia (HP:0002451)2.43007568
68Alacrima (HP:0000522)2.42067622
69Abnormal sex determination (HP:0012244)2.38264885
70Sex reversal (HP:0012245)2.38264885
71Fragile skin (HP:0001030)2.38026356
72Mutism (HP:0002300)2.37218048
73Urinary bladder sphincter dysfunction (HP:0002839)2.37084070
74Kyphoscoliosis (HP:0002751)2.34416834
75Akinesia (HP:0002304)2.30288836
76Hypokalemic alkalosis (HP:0001949)2.29679506
77Abnormality of the pulmonary veins (HP:0011718)2.29567636
78Anxiety (HP:0000739)2.21666617
79Lower limb muscle weakness (HP:0007340)2.21463565
80Sleep apnea (HP:0010535)2.19827593
81Urinary urgency (HP:0000012)2.19579729
82Polyphagia (HP:0002591)2.17398018
83Spastic tetraparesis (HP:0001285)2.15930678
84Abnormality of magnesium homeostasis (HP:0004921)2.15672513
85Hyporeflexia of lower limbs (HP:0002600)2.11516125
86Torticollis (HP:0000473)2.10058035
87Rigidity (HP:0002063)2.05830279
88Abnormality of calcium-phosphate metabolism (HP:0100530)2.04767371
89Turricephaly (HP:0000262)2.03604203
90Oligodactyly (hands) (HP:0001180)2.03458508
91Tetraplegia (HP:0002445)2.01149768
92Premature rupture of membranes (HP:0001788)2.00997195
93Overriding aorta (HP:0002623)2.00666135
94Ulnar claw (HP:0001178)16.3031057
95Segmental peripheral demyelination/remyelination (HP:0003481)13.4380090
96Termporal pattern (HP:0011008)11.6037384
97Insidious onset (HP:0003587)11.6037384
98Impaired proprioception (HP:0010831)11.3322932
99Rapidly progressive (HP:0003678)1.97054414
100Cerebral hypomyelination (HP:0006808)1.96572000
101Absent speech (HP:0001344)1.92369422
102Drooling (HP:0002307)1.92158631
103Hypoplasia of the uterus (HP:0000013)1.87636070
104Thickened helices (HP:0000391)1.87287560
105Status epilepticus (HP:0002133)1.87243961
106Epileptiform EEG discharges (HP:0011182)1.85431681
107Papilledema (HP:0001085)1.84308420
108Decreased lacrimation (HP:0000633)1.83803120
109Depression (HP:0000716)1.82486551
110Protrusio acetabuli (HP:0003179)1.82288996
111Bradykinesia (HP:0002067)1.81868444
112Stereotypic behavior (HP:0000733)1.81068709
113Hypoplasia of the corpus callosum (HP:0002079)1.80848850
114Double outlet right ventricle (HP:0001719)1.80009800
115Congenital malformation of the right heart (HP:0011723)1.80009800
116Apathy (HP:0000741)1.79974335
117Neuronal loss in central nervous system (HP:0002529)1.79813923
118Bowel incontinence (HP:0002607)1.79564956
119Impaired vibration sensation in the lower limbs (HP:0002166)1.78870042
120Excessive salivation (HP:0003781)1.78066944
121Clonus (HP:0002169)1.77450167
122Elfin facies (HP:0004428)1.75141882
123Difficulty walking (HP:0002355)1.74741258
124Bronchomalacia (HP:0002780)1.73167718
125Truncus arteriosus (HP:0001660)1.72761823
126Muscle fiber splitting (HP:0003555)1.72131843
127Retinal dysplasia (HP:0007973)1.71865100
128Morphological abnormality of the pyramidal tract (HP:0002062)1.70675223
129Abnormal drinking behavior (HP:0030082)1.68083474
130Polydipsia (HP:0001959)1.68083474
131Bundle branch block (HP:0011710)1.67351324
132Abnormal auditory evoked potentials (HP:0006958)1.63429543
133Ankle contracture (HP:0006466)1.60731739
134Cerebral aneurysm (HP:0004944)1.56661997
135Abnormality of glutamine family amino acid metabolism (HP:0010902)1.56009429
136Alopecia of scalp (HP:0002293)1.55308648
137Bladder diverticulum (HP:0000015)1.51396544
138Aortic dissection (HP:0002647)1.50784631
139Abnormality of the pupil (HP:0000615)1.48145816
140Soft skin (HP:0000977)1.46032348
141Slow progression (HP:0003677)1.42944196
142Peritonitis (HP:0002586)1.34524103
143Germ cell neoplasia (HP:0100728)1.33430521
144Gait ataxia (HP:0002066)1.30406573
145Mitral valve prolapse (HP:0001634)1.27680450
146Aplasia cutis congenita (HP:0001057)1.26710063
147Aplasia/hypoplasia of the uterus (HP:0008684)1.24229285
148Hypercalciuria (HP:0002150)1.18460376
149Pes cavus (HP:0001761)1.17007097
150Osteolytic defects of the phalanges of the hand (HP:0009771)1.15380052
151Osteolytic defects of the hand bones (HP:0009699)1.15380052
152Esophageal atresia (HP:0002032)1.14957466
153Milia (HP:0001056)1.14461597
154Dilatation of the ascending aorta (HP:0005111)1.07253631
155Renovascular hypertension (HP:0100817)1.03554258
156Gonadal dysgenesis (HP:0000133)1.01264567
157Childhood onset (HP:0011463)1.00509632
158Overgrowth (HP:0001548)1.00400067
159Heterogeneous (HP:0001425)1.00378447
160Gastrointestinal infarctions (HP:0005244)0.97288172
161Genu recurvatum (HP:0002816)0.96389247
162Juvenile onset (HP:0003621)0.95206220
163Ureteral stenosis (HP:0000071)0.94361508
164Pterygium (HP:0001059)0.92908827
165Striae distensae (HP:0001065)0.87983358
166Wormian bones (HP:0002645)0.87175620
167Ureteral obstruction (HP:0006000)0.84757937
168Neonatal short-limb short stature (HP:0008921)0.83143492
169Blue sclerae (HP:0000592)0.82798441
170Hypoventilation (HP:0002791)0.81094452
171Increased corneal curvature (HP:0100692)0.80406077
172Keratoconus (HP:0000563)0.80406077
173Hyperextensible skin (HP:0000974)0.79863561
174Variable expressivity (HP:0003828)0.79080524
175Split hand (HP:0001171)0.78236145
176Muscular dystrophy (HP:0003560)0.77511325
177Venous insufficiency (HP:0005293)0.75354842
178Bowel diverticulosis (HP:0005222)0.74484914
179Wrist flexion contracture (HP:0001239)0.74451900
180Abnormality of dentin (HP:0010299)0.73044705
181Infantile muscular hypotonia (HP:0008947)0.71701730
182Vertebral compression fractures (HP:0002953)0.70622196
183Venous abnormality (HP:0002624)0.69095921
184Trismus (HP:0000211)0.68800423
185Increased connective tissue (HP:0009025)0.67600510
186Gastrointestinal atresia (HP:0002589)0.67452443
187Nephrolithiasis (HP:0000787)0.66851257
188Axonal loss (HP:0003447)0.66841703
189Tetraparesis (HP:0002273)0.66045865
190Follicular hyperkeratosis (HP:0007502)0.66036768
191Ectopia lentis (HP:0001083)0.65700529
192Hypoplasia of the iris (HP:0007676)0.64368728
193Hematuria (HP:0000790)0.64030390

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.65540859
2IRAK25.84929609
3IRAK14.33819582
4CASK4.26672202
5NTRK23.85944198
6EPHB13.57024899
7STK392.89453710
8EPHA42.79919394
9PRKD32.57834538
10RET2.46278727
11UHMK12.44746572
12PTK62.32323392
13WNK42.25867061
14PHKG22.12962806
15PHKG12.12962806
16ICK2.03637167
17MARK21.99857701
18CAMK2B1.93679706
19KSR21.87137420
20ERBB21.80720260
21CAMK2G1.79968502
22MAP3K21.63588264
23FGFR21.52296091
24NEK61.52258288
25NTRK31.51864880
26PTK2B1.48862084
27PNCK1.47430093
28LIMK11.44036281
29SGK21.43398472
30PTK21.41955546
31CAMK2D1.38140824
32PINK11.36865919
33EPHB21.36350033
34LMTK21.34119854
35CAMKK11.31759926
36NTRK11.29465080
37MAP3K41.26932320
38TTN1.25215360
39TRIB31.23102077
40TNK21.21043565
41CAMK2A1.17134584
42MAPK151.12342355
43ERBB41.11917377
44ERBB31.11536611
45MAPKAPK51.08345427
46FES1.06527080
47DAPK21.05663597
48PLK21.05387634
49CAMK1D1.04855403
50WNK11.03934058
51STK101.03536118
52SGK11.03305025
53LRRK21.02469962
54LATS11.02036259
55SGK30.99252204
56PBK0.97925571
57CSNK1G20.96465195
58PRKCG0.96461462
59MAPK100.95986259
60PAK40.91734321
61SIK10.88665378
62PAK60.88593800
63SCYL20.88547487
64CSK0.88423477
65MAP2K10.88264137
66CDK50.88199261
67CAMK1G0.85439333
68MST40.83914532
69MET0.83900984
70MAPK120.82126427
71TNIK0.80822441
72ROCK10.79470320
73DYRK1B0.76452695
74DYRK1A0.75809439
75GSK3A0.75781454
76MINK10.74984219
77FYN0.74088854
78ROCK20.69677192
79JAK20.69427955
80PAK30.66689609
81SRC0.65520883
82TSSK60.64261168
83MAP2K70.63893925
84FER0.63401631
85CSNK1A1L0.62719942
86BMX0.61430983
87STK380.60425522
88CSNK1G30.60321847
89DDR20.59485964
90KSR10.58138582
91CAMK10.58069104
92MOS0.56914571
93PDGFRA0.56491247
94YES10.55786634
95CDK60.55459687
96ALK0.54935314
97SIK20.53955113
98PRKG10.53718348
99PRKD10.53296773
100RPS6KA30.50930327
101GRK50.50888728
102PRKCB0.50630037
103CSNK1G10.50416649
104ILK0.50239240
105TGFBR20.49817016
106RPS6KA20.49805452
107CDK11A0.49459034
108SGK2230.49325596
109SGK4940.49325596
110MAPK70.49309982
111ARAF0.49176079
112CAMKK20.49105807
113MAP2K40.47798213
114MAPK40.46414833
115PKN10.45895398
116MAP3K110.45030110
117PKN20.44922498
118ADRBK10.44091107
119DYRK20.43523997
120TESK20.43065896
121RIPK10.42707016
122CDK30.42537322
123LATS20.42376885
124PRKCZ0.42039950
125PRKCQ0.42009340
126MAP4K10.41921694
127DMPK0.41337981
128STK38L0.41134412
129TYRO30.41088741
130INSR0.40974348
131MARK10.40370149
132BMPR20.39947058
133CSNK1D0.39895357
134MAP3K10.39084183
135TGFBR10.38662858
136MAP2K60.37564438
137CAMK40.36269540
138PDGFRB0.35224149
139PRKCH0.34985725
140RAF10.34170368
141CSNK1A10.32296030
142MAP3K140.31883825
143PRKCE0.31784211
144CDK140.31631880
145PRPF4B0.31048610
146PIK3CA0.30718864
147PRKDC0.30293559
148TESK10.29566030
149FGR0.28920755
150MTOR0.28164030
151MAPK130.26908609
152CDK180.25254097
153IGF1R0.24179071
154MAP3K90.23908946
155MAP3K80.23410782
156NEK90.23238598
157CDK150.23211039
158BMPR1B0.22929452
159MATK0.22845712

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.00874019
2Nicotine addiction_Homo sapiens_hsa050333.16592176
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.01260980
4Cell adhesion molecules (CAMs)_Homo sapiens_hsa045142.94412017
5Viral myocarditis_Homo sapiens_hsa054162.65294504
6Morphine addiction_Homo sapiens_hsa050322.33591142
7Small cell lung cancer_Homo sapiens_hsa052222.30471201
8Synaptic vesicle cycle_Homo sapiens_hsa047212.25775694
9Protein digestion and absorption_Homo sapiens_hsa049742.21457054
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.20151944
11Amoebiasis_Homo sapiens_hsa051462.19864280
12Dilated cardiomyopathy_Homo sapiens_hsa054142.18974666
13Focal adhesion_Homo sapiens_hsa045102.18155606
14Amphetamine addiction_Homo sapiens_hsa050312.13577608
15Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.08170288
16Axon guidance_Homo sapiens_hsa043602.05532257
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.97021853
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.81582140
19Toxoplasmosis_Homo sapiens_hsa051451.81450979
20Cocaine addiction_Homo sapiens_hsa050301.77520643
21Dorso-ventral axis formation_Homo sapiens_hsa043201.72714591
22Tight junction_Homo sapiens_hsa045301.61827112
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.61033453
24Steroid biosynthesis_Homo sapiens_hsa001001.60257808
25Hedgehog signaling pathway_Homo sapiens_hsa043401.52644566
26cAMP signaling pathway_Homo sapiens_hsa040241.49865139
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44658701
28Glioma_Homo sapiens_hsa052141.41212727
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.38891030
30Histidine metabolism_Homo sapiens_hsa003401.32964604
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.28639911
32Oxytocin signaling pathway_Homo sapiens_hsa049211.22598857
33Vitamin B6 metabolism_Homo sapiens_hsa007501.22253055
34Taste transduction_Homo sapiens_hsa047421.19152911
35Calcium signaling pathway_Homo sapiens_hsa040201.16609870
36African trypanosomiasis_Homo sapiens_hsa051431.12805815
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10247644
38beta-Alanine metabolism_Homo sapiens_hsa004101.08556754
39Proteoglycans in cancer_Homo sapiens_hsa052051.07667093
40Fatty acid elongation_Homo sapiens_hsa000621.06992665
41Estrogen signaling pathway_Homo sapiens_hsa049151.06980977
42ErbB signaling pathway_Homo sapiens_hsa040121.06591056
43Pancreatic secretion_Homo sapiens_hsa049721.05660196
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03495670
45Platelet activation_Homo sapiens_hsa046111.01793636
46Prolactin signaling pathway_Homo sapiens_hsa049171.01695395
47Endometrial cancer_Homo sapiens_hsa052131.00136387
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99264251
49Long-term potentiation_Homo sapiens_hsa047200.98978202
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98889626
51Thyroid cancer_Homo sapiens_hsa052160.98242843
52Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97316247
53Bladder cancer_Homo sapiens_hsa052190.96739487
54Gap junction_Homo sapiens_hsa045400.94789525
55Prion diseases_Homo sapiens_hsa050200.92899049
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.92671030
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.92121992
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91845150
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91446372
60Cholinergic synapse_Homo sapiens_hsa047250.90844968
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90549720
62Long-term depression_Homo sapiens_hsa047300.89783898
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87973004
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.87718038
65Gastric acid secretion_Homo sapiens_hsa049710.87693508
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87679972
67GnRH signaling pathway_Homo sapiens_hsa049120.87404601
68Butanoate metabolism_Homo sapiens_hsa006500.86839325
69PPAR signaling pathway_Homo sapiens_hsa033200.84905946
70VEGF signaling pathway_Homo sapiens_hsa043700.84456427
71Chronic myeloid leukemia_Homo sapiens_hsa052200.84451709
72Choline metabolism in cancer_Homo sapiens_hsa052310.83675841
73PI3K-Akt signaling pathway_Homo sapiens_hsa041510.83276288
74Arginine and proline metabolism_Homo sapiens_hsa003300.79174895
75Olfactory transduction_Homo sapiens_hsa047400.78980042
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.78677341
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78433685
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77408400
79Circadian rhythm_Homo sapiens_hsa047100.75787550
80Adherens junction_Homo sapiens_hsa045200.74475556
81Renin secretion_Homo sapiens_hsa049240.73620660
82Chemokine signaling pathway_Homo sapiens_hsa040620.72235484
83Fatty acid metabolism_Homo sapiens_hsa012120.71234060
84Notch signaling pathway_Homo sapiens_hsa043300.71047313
85Circadian entrainment_Homo sapiens_hsa047130.70008774
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67660872
87Bile secretion_Homo sapiens_hsa049760.65256020
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65101871
89Fatty acid biosynthesis_Homo sapiens_hsa000610.64630852
90Shigellosis_Homo sapiens_hsa051310.64432031
91Dopaminergic synapse_Homo sapiens_hsa047280.63313248
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.62958058
93Collecting duct acid secretion_Homo sapiens_hsa049660.62178312
94Hepatitis C_Homo sapiens_hsa051600.61629302
95Salivary secretion_Homo sapiens_hsa049700.61520269
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61483264
97Alcoholism_Homo sapiens_hsa050340.60674139
98MicroRNAs in cancer_Homo sapiens_hsa052060.60397613
99Thyroid hormone synthesis_Homo sapiens_hsa049180.59879126
100Vibrio cholerae infection_Homo sapiens_hsa051100.58991053
101Inositol phosphate metabolism_Homo sapiens_hsa005620.58856157
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58416268
103Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57662278
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56876547
105Nitrogen metabolism_Homo sapiens_hsa009100.56156410
106Cardiac muscle contraction_Homo sapiens_hsa042600.56051547
107Rap1 signaling pathway_Homo sapiens_hsa040150.54897740
108Hippo signaling pathway_Homo sapiens_hsa043900.54804720
109MAPK signaling pathway_Homo sapiens_hsa040100.54280745
110Insulin secretion_Homo sapiens_hsa049110.54133427
111Pathways in cancer_Homo sapiens_hsa052000.53390053
112Melanoma_Homo sapiens_hsa052180.52722208
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52659542
114Mineral absorption_Homo sapiens_hsa049780.51441642
115Salmonella infection_Homo sapiens_hsa051320.50593229
116Osteoclast differentiation_Homo sapiens_hsa043800.50243895
117Melanogenesis_Homo sapiens_hsa049160.49761508
118Glutamatergic synapse_Homo sapiens_hsa047240.49106505
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48705136
120Oocyte meiosis_Homo sapiens_hsa041140.48324902
121Sulfur metabolism_Homo sapiens_hsa009200.48301764
122Ras signaling pathway_Homo sapiens_hsa040140.47553215
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47260242
124Endocytosis_Homo sapiens_hsa041440.46228689
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.44011997
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43787127
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39922469
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.36803200
129Serotonergic synapse_Homo sapiens_hsa047260.36566055
130Non-small cell lung cancer_Homo sapiens_hsa052230.36118745
131Ether lipid metabolism_Homo sapiens_hsa005650.35892622
132Phototransduction_Homo sapiens_hsa047440.35596550
133GABAergic synapse_Homo sapiens_hsa047270.35214902
134Renal cell carcinoma_Homo sapiens_hsa052110.34676817
135Phagosome_Homo sapiens_hsa041450.34039512
136Arginine biosynthesis_Homo sapiens_hsa002200.33852801
137ABC transporters_Homo sapiens_hsa020100.33762083
138cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33650467
139Pertussis_Homo sapiens_hsa051330.33344334
140Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33186155
141Hematopoietic cell lineage_Homo sapiens_hsa046400.32970065
142Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32353470
143Wnt signaling pathway_Homo sapiens_hsa043100.32181790
144AMPK signaling pathway_Homo sapiens_hsa041520.29675437
145mTOR signaling pathway_Homo sapiens_hsa041500.29398852
146Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26094371

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