PMP22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an integral membrane protein that is a major component of myelin in the peripheral nervous system. Studies suggest two alternately used promoters drive tissue-specific expression. Various mutations of this gene are causes of Charcot-Marie-Tooth disease Type IA, Dejerine-Sottas syndrome, and hereditary neuropathy with liability to pressure palsies. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell-cell junction maintenance (GO:0045217)5.19375622
2neuronal action potential propagation (GO:0019227)4.58556655
3angiotensin maturation (GO:0002003)4.47929476
4peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.21056300
5cell junction maintenance (GO:0034331)4.08749714
6myelination in peripheral nervous system (GO:0022011)4.03523376
7peripheral nervous system axon ensheathment (GO:0032292)4.03523376
8adhesion of symbiont to host (GO:0044406)4.03211341
9ensheathment of neurons (GO:0007272)3.97771699
10axon ensheathment (GO:0008366)3.97771699
11barbed-end actin filament capping (GO:0051016)3.97070688
12detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.82772630
13detection of temperature stimulus involved in sensory perception (GO:0050961)3.82772630
14detection of temperature stimulus (GO:0016048)3.82582160
15peptidyl-tyrosine autophosphorylation (GO:0038083)3.62691734
16cell migration involved in heart development (GO:0060973)3.62644664
17cell adhesion mediated by integrin (GO:0033627)3.52700532
18regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.48079436
19regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.41933691
20myelination (GO:0042552)3.39602922
21central nervous system myelination (GO:0022010)3.32087266
22axon ensheathment in central nervous system (GO:0032291)3.32087266
23cGMP-mediated signaling (GO:0019934)3.26917863
24myelin maintenance (GO:0043217)3.25145684
25enteric nervous system development (GO:0048484)3.25136322
26keratan sulfate catabolic process (GO:0042340)3.24587158
27collagen fibril organization (GO:0030199)3.23010401
28hemidesmosome assembly (GO:0031581)3.17551390
29fatty acid elongation (GO:0030497)3.16340869
30extracellular fibril organization (GO:0043206)3.12297331
31peripheral nervous system neuron development (GO:0048935)3.11945433
32regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.11227748
33regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.09739386
34vascular endothelial growth factor signaling pathway (GO:0038084)3.07849510
35skin morphogenesis (GO:0043589)3.05751050
36regulation of extracellular matrix disassembly (GO:0010715)3.04673591
37extracellular matrix assembly (GO:0085029)3.03110560
38neurofilament cytoskeleton organization (GO:0060052)3.02909153
39membrane raft organization (GO:0031579)3.01769202
40basement membrane organization (GO:0071711)2.95320507
41collagen catabolic process (GO:0030574)2.94467843
42response to lipoprotein particle (GO:0055094)2.88823403
43myelin assembly (GO:0032288)2.88481513
44regulation of pigment cell differentiation (GO:0050932)2.86519352
45collagen metabolic process (GO:0032963)2.86404284
46protein heterotrimerization (GO:0070208)2.83045526
47glycosphingolipid catabolic process (GO:0046479)2.81757700
48positive regulation of receptor recycling (GO:0001921)2.81337311
49apoptotic cell clearance (GO:0043277)2.79695884
50multicellular organismal catabolic process (GO:0044243)2.77465103
51multicellular organismal macromolecule metabolic process (GO:0044259)2.76137122
52dermatan sulfate biosynthetic process (GO:0030208)2.74269514
53NADH metabolic process (GO:0006734)2.64698122
54cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.63302156
55glycolipid catabolic process (GO:0019377)2.61157392
56negative regulation of leukocyte chemotaxis (GO:0002689)2.60801857
57glomerular filtration (GO:0003094)2.59854021
58multicellular organismal metabolic process (GO:0044236)2.59310351
59regulation of membrane protein ectodomain proteolysis (GO:0051043)2.58418461
60positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.58218973
61fibril organization (GO:0097435)2.58071669
62cellular response to cadmium ion (GO:0071276)2.56163647
63peptidyl-proline hydroxylation (GO:0019511)2.55508838
64stress fiber assembly (GO:0043149)2.53747437
65response to water (GO:0009415)2.52839467
66cytoskeletal anchoring at plasma membrane (GO:0007016)2.52730339
67dermatan sulfate metabolic process (GO:0030205)2.51839210
68positive regulation of p38MAPK cascade (GO:1900745)2.50991806
69fat-soluble vitamin biosynthetic process (GO:0042362)2.50984719
70negative regulation of smooth muscle cell migration (GO:0014912)2.50855218
71extracellular matrix disassembly (GO:0022617)2.50637148
72chondroitin sulfate catabolic process (GO:0030207)2.50539129
73protein targeting to plasma membrane (GO:0072661)2.49798657
74positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.47749941
75sequestering of extracellular ligand from receptor (GO:0035581)2.45316066
76regulation of early endosome to late endosome transport (GO:2000641)2.44048862
77regulation of integrin-mediated signaling pathway (GO:2001044)2.43653324
78protein retention in ER lumen (GO:0006621)2.43188222
79endodermal cell differentiation (GO:0035987)2.42693733
80blood vessel maturation (GO:0001955)2.42592655
81type B pancreatic cell proliferation (GO:0044342)2.41990209
82cellular response to nitric oxide (GO:0071732)2.41678787
83amyloid precursor protein metabolic process (GO:0042982)2.41573862
84response to methylmercury (GO:0051597)2.41115606
85renal filtration (GO:0097205)2.40404604
86negative regulation of protein localization to cell surface (GO:2000009)2.38176869
87cholesterol biosynthetic process (GO:0006695)2.37682748
88protein localization to endosome (GO:0036010)2.37408279
89positive regulation of macrophage cytokine production (GO:0060907)2.36445686
90positive regulation of pseudopodium assembly (GO:0031274)2.36293012
91adhesion of symbiont to host cell (GO:0044650)2.35979132
92virion attachment to host cell (GO:0019062)2.35979132
93regulation of mononuclear cell migration (GO:0071675)2.35889033
94maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.34750456
95sterol biosynthetic process (GO:0016126)2.34556622
96phagocytosis, engulfment (GO:0006911)2.33597416
97long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.33426390
98positive regulation by symbiont of host defense response (GO:0052509)2.33160937
99modulation by symbiont of host defense response (GO:0052031)2.33160937
100modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.33160937
101modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.33160937
102positive regulation by organism of defense response of other organism involved in symbiotic interact2.33160937
103modulation by symbiont of host immune response (GO:0052553)2.33160937
104glomerular basement membrane development (GO:0032836)2.33146292
105negative regulation of chondrocyte differentiation (GO:0032331)2.32276458
106behavioral response to pain (GO:0048266)2.31335988
107negative regulation of calcium ion transport into cytosol (GO:0010523)2.31209345
108vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.31149048
109peptide catabolic process (GO:0043171)2.31030838
110sodium ion export (GO:0071436)2.30473577
111cellular response to nicotine (GO:0071316)2.30251261
112negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.29045630
113glial cell migration (GO:0008347)2.27965967
114membrane budding (GO:0006900)2.27878492
115plasma membrane repair (GO:0001778)2.27504200
116fructose metabolic process (GO:0006000)2.27023868
117lipoprotein transport (GO:0042953)2.25916757
118neuronal action potential (GO:0019228)2.25891694
119regulation of pseudopodium assembly (GO:0031272)2.25027985
120endothelial cell chemotaxis (GO:0035767)2.24028501
121extracellular matrix organization (GO:0030198)2.23778081
122negative regulation of protein autophosphorylation (GO:0031953)2.23656572
123long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.23648055
124regulation of amyloid precursor protein catabolic process (GO:1902991)2.23637687
125cyclooxygenase pathway (GO:0019371)2.23503115
126negative regulation of nitric oxide biosynthetic process (GO:0045019)2.22891719
127retina vasculature morphogenesis in camera-type eye (GO:0061299)2.22630883
128extracellular structure organization (GO:0043062)2.22536151
129mesenchymal-epithelial cell signaling (GO:0060638)2.21793241
130import into cell (GO:0098657)2.21698244
131negative regulation of homotypic cell-cell adhesion (GO:0034111)2.20664236
132vitamin A metabolic process (GO:0006776)2.19799263
133neutrophil activation involved in immune response (GO:0002283)2.19538734
134regulation of vitamin metabolic process (GO:0030656)2.19365966
135wound healing, spreading of epidermal cells (GO:0035313)2.19318252
136Golgi transport vesicle coating (GO:0048200)2.19173742
137COPI coating of Golgi vesicle (GO:0048205)2.19173742
138negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.19100721
139mitochondrial calcium ion homeostasis (GO:0051560)2.18802212
140actin filament capping (GO:0051693)2.18172792
141cortical actin cytoskeleton organization (GO:0030866)2.18144444
142cellular response to thyroid hormone stimulus (GO:0097067)2.18120473
143regulation of guanylate cyclase activity (GO:0031282)2.17174435
144regulation of lipoprotein metabolic process (GO:0050746)2.16868049
145chondrocyte proliferation (GO:0035988)2.16211823
146glycosylceramide metabolic process (GO:0006677)2.15319983
147negative regulation of dendrite morphogenesis (GO:0050774)2.15211378
148transcytosis (GO:0045056)2.15022433
149Leydig cell differentiation (GO:0033327)2.14610261
150regulation of smooth muscle cell migration (GO:0014910)2.14260585
151response to copper ion (GO:0046688)2.13429135
152positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.13336753
153cellular component maintenance (GO:0043954)2.12704689
154nerve growth factor signaling pathway (GO:0038180)2.12328456
155actin filament depolymerization (GO:0030042)2.11540250
156ceramide catabolic process (GO:0046514)2.11215984
157long-chain fatty acid biosynthetic process (GO:0042759)2.10932887
158hormone catabolic process (GO:0042447)2.10792054
159eosinophil chemotaxis (GO:0048245)2.09944874
160axon development (GO:0061564)2.09865983
161protein hydroxylation (GO:0018126)2.09561479
162semaphorin-plexin signaling pathway (GO:0071526)2.08421185
163negative regulation of platelet activation (GO:0010544)2.08338055
164positive regulation of smooth muscle cell migration (GO:0014911)2.08215378
165positive regulation of extracellular matrix organization (GO:1903055)2.07682921
166substrate adhesion-dependent cell spreading (GO:0034446)2.06369896
167cellular response to reactive nitrogen species (GO:1902170)2.04932960
168epithelial cell-cell adhesion (GO:0090136)2.04261890
169negative regulation of vascular permeability (GO:0043116)2.03875054
170lipopolysaccharide biosynthetic process (GO:0009103)2.03651996
171positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.03441118
172positive regulation of endothelial cell apoptotic process (GO:2000353)2.00629255

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.76410951
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.03433914
3* CDX2_19796622_ChIP-Seq_MESCs_Mouse2.66309229
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.59205216
5ESR2_21235772_ChIP-Seq_MCF-7_Human2.23371635
6ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.06036627
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.03904756
8* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.03609761
9WT1_19549856_ChIP-ChIP_CCG9911_Human2.01824522
10CJUN_26792858_Chip-Seq_BT549_Human1.97628391
11* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.94693166
12SMAD_19615063_ChIP-ChIP_OVARY_Human1.89968201
13AR_21572438_ChIP-Seq_LNCaP_Human1.88050286
14GATA2_21666600_ChIP-Seq_HMVEC_Human1.87337135
15NRF2_20460467_ChIP-Seq_MEFs_Mouse1.82177126
16NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.82177126
17* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.77248370
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.76077816
19EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72634819
20RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72634819
21* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.68783826
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68384993
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.67706193
24TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.66419615
25* EP300_21415370_ChIP-Seq_HL-1_Mouse1.65860186
26* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.64642695
27SOX2_20726797_ChIP-Seq_SW620_Human1.58091266
28* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.56469394
29HIF1A_21447827_ChIP-Seq_MCF-7_Human1.54661409
30ESR1_20079471_ChIP-ChIP_T-47D_Human1.53248121
31CLOCK_20551151_ChIP-Seq_293T_Human1.52289630
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.51615808
33* TBX20_22080862_ChIP-Seq_HEART_Mouse1.50924561
34* TBX20_22328084_ChIP-Seq_HEART_Mouse1.50924561
35CDX2_20551321_ChIP-Seq_CACO-2_Human1.50892827
36* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50390397
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.49575061
38TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48704915
39* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.48004890
40BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.47394132
41* EED_16625203_ChIP-ChIP_MESCs_Mouse1.42880219
42CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.42749333
43JARID2_20075857_ChIP-Seq_MESCs_Mouse1.42617895
44AHR_22903824_ChIP-Seq_MCF-7_Human1.42077002
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.36983985
46BRD4_25478319_ChIP-Seq_HGPS_Human1.36684370
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36668581
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36587247
49NFIB_24661679_ChIP-Seq_LUNG_Mouse1.35405030
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34388405
51ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.34247494
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34186477
53PPAR_26484153_Chip-Seq_NCI-H1993_Human1.33842431
54GBX2_23144817_ChIP-Seq_PC3_Human1.33612187
55TP53_18474530_ChIP-ChIP_U2OS_Human1.23703206
56JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22371287
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20679337
58SMC1_22415368_ChIP-Seq_MEFs_Mouse1.18853386
59BP1_19119308_ChIP-ChIP_Hs578T_Human1.18658104
60NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.18579914
61LXR_22158963_ChIP-Seq_LIVER_Mouse1.18492764
62JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18421793
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18017472
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16439883
65* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.15752299
66JARID2_20064375_ChIP-Seq_MESCs_Mouse1.14520087
67SALL4_18804426_ChIP-ChIP_XEN_Mouse1.13994774
68* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13318939
69* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.13093280
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12106610
71RXR_22158963_ChIP-Seq_LIVER_Mouse1.11470127
72SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10587073
73VDR_24787735_ChIP-Seq_THP-1_Human1.09926013
74RNF2_27304074_Chip-Seq_ESCs_Mouse1.09460678
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.09241663
76EZH2_27304074_Chip-Seq_ESCs_Mouse1.08858357
77WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08835571
78TP53_16413492_ChIP-PET_HCT116_Human1.08608805
79SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06402968
80SA1_22415368_ChIP-Seq_MEFs_Mouse1.05545752
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05410613
82TP63_23658742_ChIP-Seq_EP156T_Human1.03562546
83EGR1_19032775_ChIP-ChIP_M12_Human1.02591026
84* EZH2_27294783_Chip-Seq_ESCs_Mouse1.02475990
85FOXO3_23340844_ChIP-Seq_DLD1_Human1.00956160
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.00902564
87IRF8_21731497_ChIP-ChIP_J774_Mouse1.00688265
88NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00411177
89SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00312465
90RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00227235
91* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99403858
92SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98273830
93SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98273830
94* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98189469
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97425353
96IRF8_27001747_Chip-Seq_BMDM_Mouse0.97188192
97ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.95546246
98WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95541424
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95151963
100PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94737182
101GATA1_22025678_ChIP-Seq_K562_Human0.94455296
102LXR_22292898_ChIP-Seq_THP-1_Human0.93338434
103P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93245631
104ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92700352
105* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.91368123
106* ELK3_25401928_ChIP-Seq_HUVEC_Human0.91239090
107KLF5_25053715_ChIP-Seq_YYC3_Human0.90983932
108NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90691516
109BCAT_22108803_ChIP-Seq_LS180_Human0.90419458
110* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.89659268
111FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.89633037
112* KDM2B_26808549_Chip-Seq_K562_Human0.89333621
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89230120
114SMAD4_21799915_ChIP-Seq_A2780_Human0.89016636
115P63_26484246_Chip-Seq_KERATINOCYTES_Human0.88704563
116* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.87790180
117DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87298824
118SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.86520256
119TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86387464
120NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.85227118
121UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85195670
122NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84890113
123FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.84202851
124GATA1_19941826_ChIP-Seq_K562_Human0.83450377
125IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.83311733
126CTNNB1_20460455_ChIP-Seq_HCT116_Human0.81845577
127SOX2_27498859_Chip-Seq_STOMACH_Mouse0.81522267
128UBF1/2_26484160_Chip-Seq_HMECs_Human0.79730456
129TP53_23651856_ChIP-Seq_MEFs_Mouse0.79641634
130SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79089554
131* RACK7_27058665_Chip-Seq_MCF-7_Human0.78796108

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.30172328
2MP0005275_abnormal_skin_tensile4.29925669
3MP0004272_abnormal_basement_membrane4.14166364
4MP0005503_abnormal_tendon_morphology3.99835061
5MP0001968_abnormal_touch/_nociception3.60392645
6* MP0000920_abnormal_myelination3.44111226
7MP0004858_abnormal_nervous_system3.44046999
8MP0002735_abnormal_chemical_nociception2.90279923
9MP0001958_emphysema2.69136509
10MP0003950_abnormal_plasma_membrane2.40054811
11MP0005360_urolithiasis2.28349650
12MP0002736_abnormal_nociception_after2.26198218
13MP0000751_myopathy2.24009492
14MP0003279_aneurysm2.21616654
15MP0002733_abnormal_thermal_nociception2.18258844
16MP0003045_fibrosis2.16218641
17* MP0003634_abnormal_glial_cell2.15287071
18MP0002734_abnormal_mechanical_nocicepti2.11399825
19MP0005058_abnormal_lysosome_morphology1.99545543
20MP0003136_yellow_coat_color1.98860865
21MP0005623_abnormal_meninges_morphology1.94184849
22MP0005171_absent_coat_pigmentation1.86717318
23MP0001986_abnormal_taste_sensitivity1.84518677
24MP0004270_analgesia1.81912442
25MP0001970_abnormal_pain_threshold1.76807500
26MP0005670_abnormal_white_adipose1.68335642
27MP0002108_abnormal_muscle_morphology1.51287866
28MP0003690_abnormal_glial_cell1.51072842
29MP0003705_abnormal_hypodermis_morpholog1.50505156
30MP0000604_amyloidosis1.48177482
31MP0002295_abnormal_pulmonary_circulatio1.46408545
32MP0002877_abnormal_melanocyte_morpholog1.46200323
33MP0009384_cardiac_valve_regurgitation1.39422243
34MP0005508_abnormal_skeleton_morphology1.37554508
35MP0003329_amyloid_beta_deposits1.35883647
36MP0006138_congestive_heart_failure1.28618198
37MP0003183_abnormal_peptide_metabolism1.27081883
38MP0003566_abnormal_cell_adhesion1.26980916
39MP0004134_abnormal_chest_morphology1.25422370
40MP0004510_myositis1.24982789
41MP0003633_abnormal_nervous_system1.24975043
42MP0009780_abnormal_chondrocyte_physiolo1.22728114
43MP0002933_joint_inflammation1.22533055
44MP0001299_abnormal_eye_distance/1.18010718
45MP0001533_abnormal_skeleton_physiology1.16360283
46MP0000013_abnormal_adipose_tissue1.15119981
47MP0003631_nervous_system_phenotype1.15113139
48MP0003656_abnormal_erythrocyte_physiolo1.13408153
49MP0005257_abnormal_intraocular_pressure1.11573689
50MP0001879_abnormal_lymphatic_vessel1.10983041
51MP0004019_abnormal_vitamin_homeostasis1.08669346
52MP0004084_abnormal_cardiac_muscle1.08589444
53MP0003632_abnormal_nervous_system1.07087363
54MP0001243_abnormal_dermal_layer1.06270053
55MP0005390_skeleton_phenotype1.04872529
56MP0002168_other_aberrant_phenotype1.04811531
57MP0001542_abnormal_bone_strength1.04707048
58MP0000750_abnormal_muscle_regeneration1.03878067
59MP0005164_abnormal_response_to1.02741005
60MP0010771_integument_phenotype1.01142918
61MP0003091_abnormal_cell_migration1.00760049
62MP0006082_CNS_inflammation0.98160454
63MP0000343_altered_response_to0.98017956
64MP0004883_abnormal_blood_vessel0.97601387
65MP0002060_abnormal_skin_morphology0.95911474
66MP0006276_abnormal_autonomic_nervous0.95269237
67MP0005409_darkened_coat_color0.95095384
68MP0003303_peritoneal_inflammation0.94159979
69* MP0002272_abnormal_nervous_system0.93801338
70MP0005408_hypopigmentation0.93242925
71MP0009840_abnormal_foam_cell0.91309687
72MP0009250_abnormal_appendicular_skeleto0.90847193
73MP0003828_pulmonary_edema0.90489726
74MP0002998_abnormal_bone_remodeling0.90269917
75MP0002971_abnormal_brown_adipose0.88931314
76MP0005388_respiratory_system_phenotype0.88107663
77MP0002133_abnormal_respiratory_system0.88107663
78MP0001270_distended_abdomen0.87926281
79MP0003011_delayed_dark_adaptation0.87235022
80MP0003191_abnormal_cellular_cholesterol0.87128438
81MP0003724_increased_susceptibility_to0.86728740
82MP0006054_spinal_hemorrhage0.86347515
83MP0000249_abnormal_blood_vessel0.86205520
84MP0005620_abnormal_muscle_contractility0.86203070
85MP0000372_irregular_coat_pigmentation0.84883839
86MP0000767_abnormal_smooth_muscle0.84469723
87MP0005330_cardiomyopathy0.84399995
88MP0005595_abnormal_vascular_smooth0.83964526
89MP0004036_abnormal_muscle_relaxation0.83307938
90MP0005023_abnormal_wound_healing0.83083007
91MP0004215_abnormal_myocardial_fiber0.83028634
92MP0001661_extended_life_span0.82204308
93* MP0000749_muscle_degeneration0.82156676
94* MP0000747_muscle_weakness0.80842133
95MP0010368_abnormal_lymphatic_system0.80650600
96MP0003075_altered_response_to0.79542355
97* MP0002067_abnormal_sensory_capabilities0.78782218
98MP0005167_abnormal_blood-brain_barrier0.78537667
99MP0003300_gastrointestinal_ulcer0.76936166
100MP0008775_abnormal_heart_ventricle0.74958461
101MP0000538_abnormal_urinary_bladder0.73395726
102MP0001849_ear_inflammation0.71801353
103MP0002751_abnormal_autonomic_nervous0.71723277
104MP0003172_abnormal_lysosome_physiology0.71418272
105MP0002896_abnormal_bone_mineralization0.70847720
106MP0010678_abnormal_skin_adnexa0.70655736
107MP0005165_increased_susceptibility_to0.70584676
108MP0000003_abnormal_adipose_tissue0.69685406
109MP0005197_abnormal_uvea_morphology0.68723516
110MP0005375_adipose_tissue_phenotype0.68647528
111MP0000163_abnormal_cartilage_morphology0.68533993
112MP0005166_decreased_susceptibility_to0.68279446
113MP0004145_abnormal_muscle_electrophysio0.66999419
114MP0000534_abnormal_ureter_morphology0.66964488
115MP0004484_altered_response_of0.66223773
116MP0010030_abnormal_orbit_morphology0.66168501
117MP0002972_abnormal_cardiac_muscle0.65983386
118MP0000759_abnormal_skeletal_muscle0.64882419
119MP0002938_white_spotting0.64322979
120MP0001544_abnormal_cardiovascular_syste0.63815918
121MP0005385_cardiovascular_system_phenoty0.63815918
122MP0003448_altered_tumor_morphology0.63749171
123MP0005365_abnormal_bile_salt0.63683756
124MP0000733_abnormal_muscle_development0.63555292
125MP0002115_abnormal_skeleton_extremities0.62621633
126MP0004087_abnormal_muscle_fiber0.62043743
127MP0005369_muscle_phenotype0.61909267
128MP0000230_abnormal_systemic_arterial0.61494942
129MP0000462_abnormal_digestive_system0.61254144
130MP0009115_abnormal_fat_cell0.61235425
131MP0001756_abnormal_urination0.60565912
132MP0003315_abnormal_perineum_morphology0.60129778
133MP0003385_abnormal_body_wall0.59741083

Predicted human phenotypes

RankGene SetZ-score
1* Termporal pattern (HP:0011008)6.27333448
2* Insidious onset (HP:0003587)6.27333448
3Peripheral hypomyelination (HP:0007182)5.84643958
4* Impaired proprioception (HP:0010831)5.76757204
5Upper limb muscle weakness (HP:0003484)5.08298583
6* Onion bulb formation (HP:0003383)5.08037546
7* Increased CSF protein (HP:0002922)4.83941520
8* Action tremor (HP:0002345)4.75295781
9* Steppage gait (HP:0003376)4.49631149
10* Hammertoe (HP:0001765)4.26698295
11* Foot dorsiflexor weakness (HP:0009027)4.23560801
12* Decreased number of peripheral myelinated nerve fibers (HP:0003380)4.16377167
13* Peripheral demyelination (HP:0011096)3.99796129
14Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.96836837
15* Abnormality of the foot musculature (HP:0001436)3.80185881
16Premature rupture of membranes (HP:0001788)3.77705426
17Abnormal pupillary function (HP:0007686)3.68125042
18Abnormality of liposaccharide metabolism (HP:0010968)3.64062485
19Abnormality of glycosphingolipid metabolism (HP:0004343)3.64062485
20Abnormality of glycolipid metabolism (HP:0010969)3.64062485
21* Decreased motor nerve conduction velocity (HP:0003431)3.45361427
22Protrusio acetabuli (HP:0003179)3.39454406
23Axonal loss (HP:0003447)3.33292698
24Nuclear cataract (HP:0100018)3.33129422
25Abnormality of glutamine family amino acid metabolism (HP:0010902)3.28151520
26Atrophic scars (HP:0001075)3.13602802
27White forelock (HP:0002211)3.03309217
28Hydroxyprolinuria (HP:0003080)3.01837184
29Abnormality of proline metabolism (HP:0010907)3.01837184
30Progressive sensorineural hearing impairment (HP:0000408)2.85498024
31Patchy hypopigmentation of hair (HP:0011365)2.85381067
32Spondylolisthesis (HP:0003302)2.84683469
33Fragile skin (HP:0001030)2.73689392
34Aortic dissection (HP:0002647)2.68631985
35Broad metatarsal (HP:0001783)2.65524451
36Hypomagnesemia (HP:0002917)2.64788609
37* Postural tremor (HP:0002174)2.64565995
38Dysostosis multiplex (HP:0000943)2.57925024
39* Distal sensory impairment (HP:0002936)2.45786600
40Absent frontal sinuses (HP:0002688)2.45711526
41Soft skin (HP:0000977)2.42456598
42Neurofibrillary tangles (HP:0002185)2.40960397
43* Abnormality of the vocal cords (HP:0008777)2.38542027
44Asymmetric septal hypertrophy (HP:0001670)2.37866395
45Ankle contracture (HP:0006466)2.37384954
46Abnormality of magnesium homeostasis (HP:0004921)2.36703391
47Cerebral aneurysm (HP:0004944)2.33545157
48Abnormality of complement system (HP:0005339)2.31988203
49Vertebral compression fractures (HP:0002953)2.31740708
50Bladder diverticulum (HP:0000015)2.28312045
51Complement deficiency (HP:0004431)2.28249145
52Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.27294332
53Thin bony cortex (HP:0002753)2.24909898
54Increased cerebral lipofuscin (HP:0011813)2.23078913
55Urinary glycosaminoglycan excretion (HP:0003541)2.18560755
56Mucopolysacchariduria (HP:0008155)2.18560755
57Pulmonary artery stenosis (HP:0004415)2.18522592
58Aneurysm (HP:0002617)2.16756398
59Mildly elevated creatine phosphokinase (HP:0008180)2.16448842
60Abnormality of polysaccharide metabolism (HP:0011012)2.16442114
61Abnormality of glycosaminoglycan metabolism (HP:0004371)2.16442114
62Abnormality of mucopolysaccharide metabolism (HP:0011020)2.16442114
63Aortic aneurysm (HP:0004942)2.15002203
64Malnutrition (HP:0004395)2.13637494
65Genu recurvatum (HP:0002816)2.11729558
66Pheochromocytoma (HP:0002666)2.11285135
67Osteolytic defects of the hand bones (HP:0009699)2.08627394
68Osteolytic defects of the phalanges of the hand (HP:0009771)2.08627394
69Mitral regurgitation (HP:0001653)2.08239333
70Supranuclear gaze palsy (HP:0000605)2.05014052
71Hyporeflexia of lower limbs (HP:0002600)2.04825511
72Myocardial infarction (HP:0001658)2.04814148
73Spinal rigidity (HP:0003306)2.04805309
74Systemic lupus erythematosus (HP:0002725)2.04588964
75Increased neuronal autofluorescent lipopigment (HP:0002074)2.04385725
76Abnormality of dentin (HP:0010299)2.02642971
77Wide anterior fontanel (HP:0000260)2.01981714
78Amyloidosis (HP:0011034)2.00637371
79Vascular tortuosity (HP:0004948)2.00480231
80* Ulnar claw (HP:0001178)11.5043607
81* Segmental peripheral demyelination/remyelination (HP:0003481)10.0779546
82Submucous cleft hard palate (HP:0000176)1.99551473
83Ovoid vertebral bodies (HP:0003300)1.96950359
84Zonular cataract (HP:0010920)1.96351087
85Wormian bones (HP:0002645)1.96044844
86Loss of speech (HP:0002371)1.95673497
87Difficulty walking (HP:0002355)1.92999520
88Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.92897456
89Progressive hearing impairment (HP:0001730)1.92676233
90Aortic regurgitation (HP:0001659)1.92653893
91Peritonitis (HP:0002586)1.90458358
92Follicular hyperkeratosis (HP:0007502)1.90239106
93Abnormality of skeletal muscle fiber size (HP:0012084)1.89897470
94Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.89348590
95Cupped ribs (HP:0000887)1.88380529
96Slender build (HP:0001533)1.87081094
97Striae distensae (HP:0001065)1.84326303
98Thoracolumbar scoliosis (HP:0002944)1.83515199
99Abnormality of calcium-phosphate metabolism (HP:0100530)1.83096506
100Distal lower limb muscle weakness (HP:0009053)1.83077202
101Mitral stenosis (HP:0001718)1.82262748
102Bowel diverticulosis (HP:0005222)1.80356658
103Distal arthrogryposis (HP:0005684)1.80053281
104Dilatation of the ascending aorta (HP:0005111)1.79873259
105Bundle branch block (HP:0011710)1.79605625
106Muscle fiber splitting (HP:0003555)1.78343890
107Neuroendocrine neoplasm (HP:0100634)1.77275468
108Aortic valve stenosis (HP:0001650)1.77027542
109Femoral bowing (HP:0002980)1.76856752
110Joint stiffness (HP:0001387)1.75575337
111Ulnar bowing (HP:0003031)1.75247729
112Limited hip movement (HP:0008800)1.75212328
113Distal upper limb amyotrophy (HP:0007149)1.74944224
114Upper limb amyotrophy (HP:0009129)1.74944224
115Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.74441139
116Hyperextensible skin (HP:0000974)1.73985292
117Mitral valve prolapse (HP:0001634)1.73892603
118Tibial bowing (HP:0002982)1.73697713
119Shallow orbits (HP:0000586)1.73070632
120Skin nodule (HP:0200036)1.72475869
121Abnormality of the vasculature of the conjunctiva (HP:0008054)1.71848328
122Neonatal short-limb short stature (HP:0008921)1.69812892
123Generalized amyotrophy (HP:0003700)1.69786699
124Delayed cranial suture closure (HP:0000270)1.69742908
125Protuberant abdomen (HP:0001538)1.69592348
126Disproportionate tall stature (HP:0001519)1.69348055
127Congenital sensorineural hearing impairment (HP:0008527)1.69145368
128Cerebral inclusion bodies (HP:0100314)1.67358408
129Increased connective tissue (HP:0009025)1.66608221
130Increased variability in muscle fiber diameter (HP:0003557)1.66200012
131Ectopia lentis (HP:0001083)1.65876718
132Arterial tortuosity (HP:0005116)1.65332291
133Increased corneal curvature (HP:0100692)1.64506761
134Keratoconus (HP:0000563)1.64506761
135Bone cyst (HP:0012062)1.64198247
136Conjunctival telangiectasia (HP:0000524)1.63545237
137Osteoarthritis (HP:0002758)1.63053903
138Wrist flexion contracture (HP:0001239)1.63007894
139Pterygium (HP:0001059)1.62790626
140Camptodactyly of toe (HP:0001836)1.62591778
141Hypoplasia of the iris (HP:0007676)1.60746727
142Overgrowth (HP:0001548)1.60629806
143Abnormal auditory evoked potentials (HP:0006958)1.58968572
144* Kyphoscoliosis (HP:0002751)1.57223753
145Cervical subluxation (HP:0003308)1.55311261
146Alopecia of scalp (HP:0002293)1.54400220
147Myotonia (HP:0002486)1.52641202
148Vacuolated lymphocytes (HP:0001922)1.52171395
149Lumbar hyperlordosis (HP:0002938)1.51800503
150Cerebral hemorrhage (HP:0001342)1.51382771
151Blue sclerae (HP:0000592)1.50597345
152Hypercortisolism (HP:0001578)1.49495998
153Metaphyseal dysplasia (HP:0100255)1.47761447
154Ankle clonus (HP:0011448)1.47716418
155Hypoventilation (HP:0002791)1.47202784
156Difficulty running (HP:0009046)1.47131179
157Autoamputation (HP:0001218)1.45768337
158Glomerulonephritis (HP:0000099)1.45535516
159Bradycardia (HP:0001662)1.44817713
160Type 1 muscle fiber predominance (HP:0003803)1.44034348

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB13.85277350
2MAPKAPK53.13491633
3STK392.96575495
4NTRK12.94027833
5PDK22.90146786
6LIMK12.86542149
7LMTK22.46621595
8KSR22.41446990
9MAP3K22.27539673
10IRAK22.10622597
11MET2.10538365
12RET1.98743728
13EPHA31.92029588
14TGFBR21.90504774
15RIPK41.74607133
16IRAK11.74364685
17MAP3K121.74055858
18DDR21.66459438
19ABL21.66003001
20MAP3K31.63496446
21PAK41.61399658
22ACVR1B1.60090957
23MST1R1.57316692
24PBK1.56467906
25WNK41.52844661
26FER1.50604570
27TNIK1.45744127
28IRAK31.43122292
29EPHB21.40469466
30MST41.38512381
31PTK2B1.35435823
32WNK11.32478291
33PRKD31.28345900
34GRK51.26800768
35MATK1.22197850
36MAP2K11.21630265
37MAP2K21.19403104
38TYK21.18193223
39CDC42BPA1.17373096
40FGFR21.15484987
41SGK2231.14455954
42SGK4941.14455954
43PIM21.10313040
44CAMK1D1.09571588
45STK241.08754658
46TESK11.07906154
47NME21.04113257
48MAPKAPK31.03150791
49LATS21.03107789
50PIK3CA1.02993898
51UHMK11.01200812
52ERBB41.00101942
53NEK90.99533065
54PHKG10.98813868
55PHKG20.98813868
56PRKG20.98006629
57TRPM70.97736550
58MUSK0.95434379
59TTN0.92751735
60BMX0.92418114
61PTK20.91792382
62MAPK70.90880798
63PAK60.89976565
64MINK10.89161719
65MAP3K10.88968727
66CAMK1G0.87578409
67PDGFRA0.86659840
68ROCK20.86622411
69PRKD10.84043760
70CAMK2B0.83881768
71GSK3A0.81805307
72ERBB20.81600450
73TRIB30.81490789
74LRRK20.81093049
75PRKCE0.80510664
76PLK20.80350720
77ARAF0.79947578
78CAMKK20.76962501
79RPS6KA20.75682686
80ROCK10.75443783
81MARK30.73292754
82BLK0.71156785
83PDGFRB0.70644719
84DAPK30.70145608
85PRPF4B0.70042650
86SIK30.69741046
87CAMK2D0.69477732
88MAPK120.69099209
89TIE10.68500475
90TESK20.68329565
91RIPK10.67931838
92PKN10.67433727
93MYLK0.66250892
94EPHA20.64601443
95TBK10.62789839
96NEK60.61583782
97TAOK20.61509676
98BCR0.61296881
99SRC0.60760282
100GRK70.59622252
101ERN10.58550644
102MOS0.57928028
103MAPK40.57140753
104CDK140.56417002
105PTK60.55200547
106PAK30.55052961
107SIK10.54620861
108MARK20.54530357
109MAPKAPK20.53829630
110YES10.52925082
111JAK10.52435825
112FYN0.52169747
113CAMK2A0.51291195
114FGFR30.50918587
115FGFR40.49074305
116CDK50.48327304
117ADRBK10.47917748
118DMPK0.47875970
119NEK10.46274451
120TYRO30.46156083
121NLK0.45574132
122PRKCH0.45078590
123PAK20.43940065
124FRK0.43294283
125ILK0.42970681
126BMPR1B0.42899396
127IGF1R0.42178720
128PRKAA20.42120209
129PDPK10.41681982
130PKN20.41466763
131CAMK2G0.40146053
132INSR0.40053187
133MARK10.40034654
134PRKD20.38077619
135EPHA40.37594779
136STK380.37342039
137CDK180.32428058
138PRKACG0.31170133
139NTRK30.30957560
140ABL10.29741685

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001002.70308925
2ECM-receptor interaction_Homo sapiens_hsa045122.48710251
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.46203796
4PPAR signaling pathway_Homo sapiens_hsa033202.00884840
5Cyanoamino acid metabolism_Homo sapiens_hsa004601.94108062
6Fatty acid elongation_Homo sapiens_hsa000621.85562095
7Lysosome_Homo sapiens_hsa041421.81854334
8Protein digestion and absorption_Homo sapiens_hsa049741.76714533
9Mineral absorption_Homo sapiens_hsa049781.71489491
10Galactose metabolism_Homo sapiens_hsa000521.65284221
11Phagosome_Homo sapiens_hsa041451.61974032
12Amoebiasis_Homo sapiens_hsa051461.59878161
13Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.58739099
14Fat digestion and absorption_Homo sapiens_hsa049751.58595629
15Vitamin digestion and absorption_Homo sapiens_hsa049771.54132068
16Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.53260419
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50943374
18Dorso-ventral axis formation_Homo sapiens_hsa043201.49155051
19Focal adhesion_Homo sapiens_hsa045101.49116203
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.38892642
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.32063725
22Fructose and mannose metabolism_Homo sapiens_hsa000511.31217091
23Salmonella infection_Homo sapiens_hsa051321.30481057
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.29047687
25Ether lipid metabolism_Homo sapiens_hsa005651.24808858
26Malaria_Homo sapiens_hsa051441.23888191
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23602325
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.23373227
29Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.22919688
30Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.20766548
31Sphingolipid metabolism_Homo sapiens_hsa006001.19123356
32Pertussis_Homo sapiens_hsa051331.17112708
33Arginine and proline metabolism_Homo sapiens_hsa003301.14982086
34Complement and coagulation cascades_Homo sapiens_hsa046101.14845752
35Dilated cardiomyopathy_Homo sapiens_hsa054141.14834537
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14631238
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.14389856
38Viral myocarditis_Homo sapiens_hsa054161.13213796
39Axon guidance_Homo sapiens_hsa043601.12426402
40Toxoplasmosis_Homo sapiens_hsa051451.09957241
41Renin-angiotensin system_Homo sapiens_hsa046141.09363086
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06743712
43Sphingolipid signaling pathway_Homo sapiens_hsa040711.06546249
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05046251
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.04050122
46Rheumatoid arthritis_Homo sapiens_hsa053231.03116357
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02630066
48Endocytosis_Homo sapiens_hsa041441.01735387
49Leukocyte transendothelial migration_Homo sapiens_hsa046701.01016623
50Prion diseases_Homo sapiens_hsa050200.99991739
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97879745
52Bile secretion_Homo sapiens_hsa049760.96896775
53Proteoglycans in cancer_Homo sapiens_hsa052050.96536497
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95608775
55Staphylococcus aureus infection_Homo sapiens_hsa051500.94492251
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89878659
57Starch and sucrose metabolism_Homo sapiens_hsa005000.88503587
58Melanoma_Homo sapiens_hsa052180.88127430
59Tight junction_Homo sapiens_hsa045300.87686392
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86833016
61Glutathione metabolism_Homo sapiens_hsa004800.85670016
62PI3K-Akt signaling pathway_Homo sapiens_hsa041510.85453407
63Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84347612
64Leishmaniasis_Homo sapiens_hsa051400.83761691
65Glioma_Homo sapiens_hsa052140.83596476
66Platelet activation_Homo sapiens_hsa046110.83470255
67Renal cell carcinoma_Homo sapiens_hsa052110.81317351
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80850876
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78986688
70Tuberculosis_Homo sapiens_hsa051520.77497080
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.76906441
72African trypanosomiasis_Homo sapiens_hsa051430.76179449
73Vibrio cholerae infection_Homo sapiens_hsa051100.75863481
74Adherens junction_Homo sapiens_hsa045200.74469907
75Thyroid cancer_Homo sapiens_hsa052160.73778671
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.73613486
77Pentose phosphate pathway_Homo sapiens_hsa000300.73568856
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73363086
79Osteoclast differentiation_Homo sapiens_hsa043800.73169979
80Rap1 signaling pathway_Homo sapiens_hsa040150.72633471
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72277779
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71892161
83Arginine biosynthesis_Homo sapiens_hsa002200.70999849
84Hedgehog signaling pathway_Homo sapiens_hsa043400.70967629
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70750405
86Gap junction_Homo sapiens_hsa045400.70101198
87Ras signaling pathway_Homo sapiens_hsa040140.68403891
88Shigellosis_Homo sapiens_hsa051310.67821634
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67279917
90Sulfur metabolism_Homo sapiens_hsa009200.66676710
91Salivary secretion_Homo sapiens_hsa049700.66104929
92Thyroid hormone synthesis_Homo sapiens_hsa049180.64983024
93Renin secretion_Homo sapiens_hsa049240.63923553
94TGF-beta signaling pathway_Homo sapiens_hsa043500.62862608
95Other glycan degradation_Homo sapiens_hsa005110.61781400
96Synaptic vesicle cycle_Homo sapiens_hsa047210.61653502
97Histidine metabolism_Homo sapiens_hsa003400.61485026
98Long-term depression_Homo sapiens_hsa047300.61365449
99Chemokine signaling pathway_Homo sapiens_hsa040620.61205831
100Folate biosynthesis_Homo sapiens_hsa007900.61113795
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61072273
102VEGF signaling pathway_Homo sapiens_hsa043700.60643692
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.60377845
104Melanogenesis_Homo sapiens_hsa049160.60109666
105Glycerolipid metabolism_Homo sapiens_hsa005610.59578916
106Toll-like receptor signaling pathway_Homo sapiens_hsa046200.59544779
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59047878
108Cholinergic synapse_Homo sapiens_hsa047250.58254706
109Pancreatic cancer_Homo sapiens_hsa052120.57257243
110Cocaine addiction_Homo sapiens_hsa050300.57129675
111GnRH signaling pathway_Homo sapiens_hsa049120.56422295
112Gastric acid secretion_Homo sapiens_hsa049710.56169103
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55620009
114Estrogen signaling pathway_Homo sapiens_hsa049150.54522789
115ErbB signaling pathway_Homo sapiens_hsa040120.54383633
116TNF signaling pathway_Homo sapiens_hsa046680.52672750
117Chronic myeloid leukemia_Homo sapiens_hsa052200.52327487
118Fatty acid degradation_Homo sapiens_hsa000710.52001185
119Hepatitis C_Homo sapiens_hsa051600.51675934
120Pathways in cancer_Homo sapiens_hsa052000.51012479
121Small cell lung cancer_Homo sapiens_hsa052220.50708947
122Arachidonic acid metabolism_Homo sapiens_hsa005900.50429449
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.50088936
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49777820
125Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49301476
126Collecting duct acid secretion_Homo sapiens_hsa049660.48701247
127Pancreatic secretion_Homo sapiens_hsa049720.48580545
128Fatty acid metabolism_Homo sapiens_hsa012120.48196415
129Endometrial cancer_Homo sapiens_hsa052130.48054141
130Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46138973
131Tryptophan metabolism_Homo sapiens_hsa003800.45323591
132beta-Alanine metabolism_Homo sapiens_hsa004100.44859068
133Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41324401
134Bladder cancer_Homo sapiens_hsa052190.41178043
135Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39137371
136Chemical carcinogenesis_Homo sapiens_hsa052040.38587487
137Phenylalanine metabolism_Homo sapiens_hsa003600.36527946
138HIF-1 signaling pathway_Homo sapiens_hsa040660.35997762
139Insulin resistance_Homo sapiens_hsa049310.35398967

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