PMPCAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of membrane potential (GO:0045837)7.91704713
2protein K48-linked deubiquitination (GO:0071108)7.61398588
3histone deubiquitination (GO:0016578)6.98376058
4regulation of mitochondrial translation (GO:0070129)6.11990349
5histone H3-K9 demethylation (GO:0033169)5.82979875
6water-soluble vitamin biosynthetic process (GO:0042364)5.81075213
7positive regulation of endothelial cell differentiation (GO:0045603)5.66183094
8negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)5.58070569
9positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc5.57710554
10pseudouridine synthesis (GO:0001522)5.42212781
11protein neddylation (GO:0045116)5.36657599
12response to gravity (GO:0009629)5.01194327
13regulation of secondary heart field cardioblast proliferation (GO:0003266)4.98490168
14regulation of cardioblast proliferation (GO:0003264)4.98490168
15base-excision repair, AP site formation (GO:0006285)4.97663375
16pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.95519577
17protein complex biogenesis (GO:0070271)4.88308181
18kidney mesenchyme development (GO:0072074)4.83648140
19mitochondrial respiratory chain complex assembly (GO:0033108)4.83257477
20misfolded or incompletely synthesized protein catabolic process (GO:0006515)4.81296497
21negative regulation of DNA-templated transcription, elongation (GO:0032785)4.77775932
22outer ear morphogenesis (GO:0042473)4.61268643
23embryonic skeletal joint morphogenesis (GO:0060272)4.57007590
24regulation of glucocorticoid metabolic process (GO:0031943)4.37413815
25protein import into peroxisome matrix (GO:0016558)4.09608781
26pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.04586128
27regulation of response to osmotic stress (GO:0047484)4.04525231
28negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.04379332
29regulation of endothelial cell differentiation (GO:0045601)3.94435380
30pyrimidine nucleotide catabolic process (GO:0006244)3.93953220
31regulation of fatty acid beta-oxidation (GO:0031998)3.73642756
32resolution of meiotic recombination intermediates (GO:0000712)3.66321600
33protein K6-linked ubiquitination (GO:0085020)3.62618268
34protein localization to kinetochore (GO:0034501)3.61600309
35cytochrome complex assembly (GO:0017004)3.58880620
36middle ear morphogenesis (GO:0042474)3.56394092
37tooth mineralization (GO:0034505)3.49936365
38synaptonemal complex organization (GO:0070193)3.47422323
39regulation of glucocorticoid secretion (GO:2000849)3.46915352
40maturation of 5.8S rRNA (GO:0000460)3.41047821
41viral mRNA export from host cell nucleus (GO:0046784)3.40357976
42serotonin metabolic process (GO:0042428)3.40033826
43regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:23.39995779
44replication fork processing (GO:0031297)3.36352826
45transcription from mitochondrial promoter (GO:0006390)3.35605477
46embryonic heart tube development (GO:0035050)3.35057968
47positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)3.33566670
48cobalamin metabolic process (GO:0009235)3.32751565
49negative regulation of calcium ion transport into cytosol (GO:0010523)3.31590588
50thyroid gland development (GO:0030878)3.31083247
51oxidative phosphorylation (GO:0006119)3.30247825
52lymph vessel development (GO:0001945)3.29255840
53adaptation of signaling pathway (GO:0023058)3.26304442
54synaptonemal complex assembly (GO:0007130)3.25923715
55DNA replication checkpoint (GO:0000076)3.20048678
56cranial nerve morphogenesis (GO:0021602)3.18369449
57positive regulation of muscle cell apoptotic process (GO:0010661)3.13548101
58metanephric mesenchyme development (GO:0072075)3.12526271
59regulation of heart morphogenesis (GO:2000826)3.09964119
60myoblast migration (GO:0051451)3.02230486
61circadian behavior (GO:0048512)3.01956484
62mitochondrial RNA metabolic process (GO:0000959)3.00627558
63protein localization to chromosome, centromeric region (GO:0071459)3.00483517
64response to vitamin A (GO:0033189)2.99562735
65regulation of translational fidelity (GO:0006450)2.99287075
66organ induction (GO:0001759)2.99283343
67positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.98886952
68positive regulation of hair cycle (GO:0042635)2.97860674
69positive regulation of hair follicle development (GO:0051798)2.97860674
70regulation of activin receptor signaling pathway (GO:0032925)2.96285401
71proteasome assembly (GO:0043248)2.96136676
72heterochromatin organization (GO:0070828)2.89288742
73regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.87441668
74protein localization to peroxisome (GO:0072662)2.86718006
75protein targeting to peroxisome (GO:0006625)2.86718006
76establishment of protein localization to peroxisome (GO:0072663)2.86718006
77cellular response to osmotic stress (GO:0071470)2.86216401
78neuron fate specification (GO:0048665)2.85726639
79L-phenylalanine metabolic process (GO:0006558)2.85605813
80erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.85605813
81mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.82760173
82mitochondrial respiratory chain complex I assembly (GO:0032981)2.82760173
83NADH dehydrogenase complex assembly (GO:0010257)2.82760173
84primary amino compound metabolic process (GO:1901160)2.82310139
85histone phosphorylation (GO:0016572)2.78996067
86pharyngeal system development (GO:0060037)2.77737076
87rhythmic behavior (GO:0007622)2.76596026
88retinal rod cell development (GO:0046548)2.75807094
89vitamin biosynthetic process (GO:0009110)2.75488224
90positive regulation of signal transduction by p53 class mediator (GO:1901798)2.74940784
91regulation of mammary gland epithelial cell proliferation (GO:0033599)2.73945156
92regulation of myeloid cell apoptotic process (GO:0033032)2.73483614
93regulation of corticosteroid hormone secretion (GO:2000846)2.70966627
94cochlea morphogenesis (GO:0090103)2.67453689
95pteridine-containing compound biosynthetic process (GO:0042559)2.67277480
96regulation of signal transduction by p53 class mediator (GO:1901796)2.65267283
97kinetochore assembly (GO:0051382)2.60509253
98N-terminal protein amino acid acetylation (GO:0006474)2.60140032
99positive regulation of fatty acid beta-oxidation (GO:0032000)2.59704685
100monoubiquitinated protein deubiquitination (GO:0035520)14.3805239

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.35638190
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.95344986
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.61075125
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.32807384
5CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.32651646
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.21674397
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.06983526
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.05626372
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.01632182
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.75187420
11CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.66147555
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.55712897
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.52160810
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.40279822
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.34182377
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.31745107
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.22673373
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.17147743
19GABP_19822575_ChIP-Seq_HepG2_Human2.14563573
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.13999424
21CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.11640499
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.07332517
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.07332517
24KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.07332517
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.03094015
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.98833219
27TTF2_22483619_ChIP-Seq_HELA_Human1.96024540
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.93226244
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.89635617
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.89623036
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89296663
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89114226
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.88694359
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.88396366
35ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.86467643
36DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.80029738
37XRN2_22483619_ChIP-Seq_HELA_Human1.77296666
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.77009391
39NCOR1_26117541_ChIP-Seq_K562_Human1.73072487
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.71278694
41DCP1A_22483619_ChIP-Seq_HELA_Human1.69086709
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.68854083
43IRF1_19129219_ChIP-ChIP_H3396_Human1.67211025
44MYC_19030024_ChIP-ChIP_MESCs_Mouse1.66680442
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.66106120
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62048217
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.59798286
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.57946081
49AR_21909140_ChIP-Seq_LNCAP_Human1.54608569
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.51636989
51TP53_20018659_ChIP-ChIP_R1E_Mouse1.49539043
52CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.47974954
53SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.45064288
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43956765
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.42123795
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39904719
57FOXP3_21729870_ChIP-Seq_TREG_Human1.38603067
58CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.38025275
59VDR_23849224_ChIP-Seq_CD4+_Human1.34076227
60E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33855998
61CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.33766222
62EZH2_27304074_Chip-Seq_ESCs_Mouse1.33000480
63KDM5A_27292631_Chip-Seq_BREAST_Human1.27663995
64SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.27293032
65CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.22435885
66SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.21291230
67CREB1_15753290_ChIP-ChIP_HEK293T_Human1.21177289
68STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.18970353
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18276749
70NCOR_22424771_ChIP-Seq_293T_Human1.16649701
71GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13288715
72TBX5_21415370_ChIP-Seq_HL-1_Mouse1.12882920
73CTCF_21964334_Chip-Seq_Bcells_Human1.11007843
74PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10785535
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09536943
76TET1_21451524_ChIP-Seq_MESCs_Mouse1.09529972
77CIITA_25753668_ChIP-Seq_RAJI_Human1.08607404
78E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07983631
79KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05839513
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05520204
81RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03260182
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01130931
83CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00466553
84VDR_22108803_ChIP-Seq_LS180_Human1.00453353
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99012252
86RAC3_21632823_ChIP-Seq_H3396_Human0.96634519
87BCL6_27268052_Chip-Seq_Bcells_Human0.95854076
88ELK3_25401928_ChIP-Seq_HUVEC_Human0.94998892
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94766224
90GATA1_26923725_Chip-Seq_HPCs_Mouse0.94300866
91P68_20966046_ChIP-Seq_HELA_Human0.93947112
92NANOG_16153702_ChIP-ChIP_HESCs_Human0.93676783
93CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.93387321
94SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.89677105
95GATA1_22383799_ChIP-Seq_G1ME_Mouse0.87532473
96CTCF_20526341_ChIP-Seq_ESCs_Human0.87209639
97RARA_24833708_ChIP-Seq_LIVER_Mouse0.86483424
98MYC_18940864_ChIP-ChIP_HL60_Human0.86109912
99YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85541593
100LXR_22292898_ChIP-Seq_THP-1_Human0.85408420

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue8.27681366
2MP0002837_dystrophic_cardiac_calcinosis4.96886394
3MP0004185_abnormal_adipocyte_glucose3.52939842
4MP0005670_abnormal_white_adipose3.25896992
5MP0002736_abnormal_nociception_after3.18999224
6MP0002163_abnormal_gland_morphology2.82847315
7MP0001346_abnormal_lacrimal_gland2.67967243
8MP0005623_abnormal_meninges_morphology2.65401636
9MP0003122_maternal_imprinting2.64048561
10MP0003123_paternal_imprinting2.61194056
11MP0003890_abnormal_embryonic-extraembry2.55415694
12MP0000678_abnormal_parathyroid_gland2.48352761
13MP0000537_abnormal_urethra_morphology2.42794330
14MP0008775_abnormal_heart_ventricle2.41051974
15MP0001968_abnormal_touch/_nociception2.18030893
16MP0010234_abnormal_vibrissa_follicle2.17510135
17MP0002249_abnormal_larynx_morphology2.11793318
18MP0002877_abnormal_melanocyte_morpholog2.07217305
19MP0002277_abnormal_respiratory_mucosa1.98040412
20MP0005666_abnormal_adipose_tissue1.97367389
21MP0008058_abnormal_DNA_repair1.92048768
22MP0005367_renal/urinary_system_phenotyp1.88947440
23MP0000516_abnormal_urinary_system1.88947440
24MP0001270_distended_abdomen1.66441823
25MP0010307_abnormal_tumor_latency1.64928057
26MP0003693_abnormal_embryo_hatching1.62873757
27MP0004130_abnormal_muscle_cell1.60229722
28MP0001853_heart_inflammation1.59893220
29MP0004133_heterotaxia1.58973434
30MP0002160_abnormal_reproductive_system1.58947093
31MP0000049_abnormal_middle_ear1.57000115
32MP0001502_abnormal_circadian_rhythm1.56638124
33MP0003121_genomic_imprinting1.54662462
34MP0003942_abnormal_urinary_system1.41202218
35MP0010030_abnormal_orbit_morphology1.39340265
36MP0000681_abnormal_thyroid_gland1.38711546
37MP0005408_hypopigmentation1.38413521
38MP0003011_delayed_dark_adaptation1.37421642
39MP0001188_hyperpigmentation1.33553664
40MP0000372_irregular_coat_pigmentation1.31970317
41MP0000343_altered_response_to1.25032952
42MP0002735_abnormal_chemical_nociception1.21765696
43MP0001905_abnormal_dopamine_level1.16681338
44MP0005379_endocrine/exocrine_gland_phen1.16123923
45MP0004742_abnormal_vestibular_system1.11986935
46MP0005646_abnormal_pituitary_gland1.11053615
47MP0002234_abnormal_pharynx_morphology1.11052502
48MP0006292_abnormal_olfactory_placode1.09947048
49MP0003111_abnormal_nucleus_morphology1.07787485
50MP0009250_abnormal_appendicular_skeleto1.06324290
51MP0005375_adipose_tissue_phenotype1.06315081
52MP0003937_abnormal_limbs/digits/tail_de1.01539256
53MP0001486_abnormal_startle_reflex1.00948185
54MP0001849_ear_inflammation0.99899180
55MP0000538_abnormal_urinary_bladder0.99649919
56MP0000733_abnormal_muscle_development0.99438868
57MP0002282_abnormal_trachea_morphology0.99206027
58MP0003136_yellow_coat_color0.98703444
59MP0008007_abnormal_cellular_replicative0.93331443
60MP0000534_abnormal_ureter_morphology0.90661089
61MP0002932_abnormal_joint_morphology0.90377555
62MP0002938_white_spotting0.87390464
63MP0003077_abnormal_cell_cycle0.85132506
64MP0001666_abnormal_nutrient_absorption0.83626261
65MP0001879_abnormal_lymphatic_vessel0.81709080
66MP0003786_premature_aging0.80362571
67MP0005058_abnormal_lysosome_morphology0.78194522
68MP0001727_abnormal_embryo_implantation0.77020171
69MP0004147_increased_porphyrin_level0.76433244
70MP0002177_abnormal_outer_ear0.76159873
71MP0010094_abnormal_chromosome_stability0.74446237
72MP0001529_abnormal_vocalization0.73360046
73MP0005386_behavior/neurological_phenoty0.70508426
74MP0004924_abnormal_behavior0.70508426
75MP0005083_abnormal_biliary_tract0.69559413
76MP0001730_embryonic_growth_arrest0.68560965
77MP0003755_abnormal_palate_morphology0.68428593
78MP0004858_abnormal_nervous_system0.68249745
79MP0005389_reproductive_system_phenotype0.66880033
80MP0004782_abnormal_surfactant_physiolog0.64554966
81MP0002210_abnormal_sex_determination0.63069553
82MP0003137_abnormal_impulse_conducting0.63063223
83MP0009046_muscle_twitch0.62970848
84MP0001286_abnormal_eye_development0.62453378
85MP0009384_cardiac_valve_regurgitation0.62438030
86MP0001881_abnormal_mammary_gland0.61895640
87MP0001929_abnormal_gametogenesis0.61362456
88MP0005410_abnormal_fertilization0.60946417
89MP0005332_abnormal_amino_acid0.60661300
90MP0008932_abnormal_embryonic_tissue0.58431987
91MP0003699_abnormal_female_reproductive0.54145426
92MP0009765_abnormal_xenobiotic_induced0.53303878
93MP0001340_abnormal_eyelid_morphology0.52273979
94MP0003936_abnormal_reproductive_system0.52111771
95MP0009115_abnormal_fat_cell0.51636434
96MP0002114_abnormal_axial_skeleton0.50007467
97MP0002085_abnormal_embryonic_tissue0.49786879
98MP0003950_abnormal_plasma_membrane0.48945902
99MP0001963_abnormal_hearing_physiology0.46432301
100MP0000759_abnormal_skeletal_muscle0.46293526

Predicted human phenotypes

RankGene SetZ-score
1Meningioma (HP:0002858)7.01861828
2Hyperglycinemia (HP:0002154)5.06317444
3Methylmalonic aciduria (HP:0012120)4.97422610
4Lymphangioma (HP:0100764)4.91319592
5Methylmalonic acidemia (HP:0002912)4.62870259
6Melanoma (HP:0002861)4.42557267
7Hyperthyroidism (HP:0000836)3.97591725
8Neoplasm of the lung (HP:0100526)3.54251969
9Nonimmune hydrops fetalis (HP:0001790)3.47446012
10Birth length less than 3rd percentile (HP:0003561)3.33253651
11Benign neoplasm of the central nervous system (HP:0100835)3.24714745
12Neoplasm of the respiratory system (HP:0100606)3.16119935
13Short middle phalanx of the 5th finger (HP:0004220)3.04228517
14Abnormal gallbladder physiology (HP:0012438)2.99466138
15Cholecystitis (HP:0001082)2.99466138
16Abnormality of the phalanges of the hallux (HP:0010057)2.95574253
17Aplastic anemia (HP:0001915)2.73605497
18Concave nail (HP:0001598)2.73305460
19Abnormality of the vitamin B12 metabolism (HP:0004341)2.72664452
20Amblyopia (HP:0000646)2.71576206
21Small epiphyses (HP:0010585)2.55322871
22Neonatal onset (HP:0003623)2.51458295
23Abnormality of dicarboxylic acid metabolism (HP:0010995)2.50235414
24Dicarboxylic aciduria (HP:0003215)2.50235414
25Abnormality of vitamin B metabolism (HP:0004340)2.44601120
26Ketosis (HP:0001946)2.43394133
27Abnormality of glycine metabolism (HP:0010895)2.42947420
28Abnormality of serine family amino acid metabolism (HP:0010894)2.42947420
29Abnormality of the line of Schwalbe (HP:0008048)2.42251851
30Exostoses (HP:0100777)2.40605222
31Abnormality of the distal phalanges of the toes (HP:0010182)2.39234359
32Subacute progressive viral hepatitis (HP:0006572)2.35964782
33Multiple enchondromatosis (HP:0005701)2.35571887
34Ileus (HP:0002595)2.35266309
35Broad distal phalanx of finger (HP:0009836)2.33528219
36Abdominal distention (HP:0003270)2.32331897
37Ureteral duplication (HP:0000073)2.29402062
38Microretrognathia (HP:0000308)2.28449965
39Truncus arteriosus (HP:0001660)2.28355739
40Abnormality of aromatic amino acid family metabolism (HP:0004338)2.27018887
41Hypoplasia of the uterus (HP:0000013)2.25363222
42Abnormality of the parathyroid morphology (HP:0011766)2.25192102
43Ulnar deviation of the wrist (HP:0003049)2.24533370
44Squamous cell carcinoma (HP:0002860)2.23659625
45Enlarged penis (HP:0000040)2.22605595
46Lower limb asymmetry (HP:0100559)2.19995763
47Abnormality of the fetal cardiovascular system (HP:0010948)2.19274196
48Abnormal umbilical cord blood vessels (HP:0011403)2.19274196
49Single umbilical artery (HP:0001195)2.19274196
50Hyperammonemia (HP:0001987)2.19234012
51Periauricular skin pits (HP:0100277)2.17386931
52Preauricular pit (HP:0004467)2.17386931
53Neoplasm of the adrenal gland (HP:0100631)2.14565291
54Abnormality of serum amino acid levels (HP:0003112)2.13931054
55Lip pit (HP:0100267)2.11423109
56Abnormality of the aortic arch (HP:0012303)2.10574485
57Pancytopenia (HP:0001876)2.05362236
58Spastic paraparesis (HP:0002313)2.02715722
59Aplasia/Hypoplasia of the sacrum (HP:0008517)2.01400527
60Septate vagina (HP:0001153)2.00495356
61Cutaneous melanoma (HP:0012056)18.7188306
62Seborrheic dermatitis (HP:0001051)1.99182800
63Respiratory distress (HP:0002098)1.98810497
64Hepatocellular carcinoma (HP:0001402)1.98416026
65Abnormality of the 4th metacarpal (HP:0010012)1.97369429
66Neoplasm of the adrenal cortex (HP:0100641)1.97211171
67Hypoplastic left heart (HP:0004383)1.96898824
68Posterior embryotoxon (HP:0000627)1.95490456
69Anxiety (HP:0000739)1.95100878
70Short femoral neck (HP:0100864)1.93023720
71Obsessive-compulsive behavior (HP:0000722)1.92579743
72Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.90646891
73Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.90538630
74Abnormality of the middle phalanges of the toes (HP:0010183)1.86016351
75Atresia of the external auditory canal (HP:0000413)1.85560441
76Ectopic kidney (HP:0000086)1.84481763
77Aplasia/Hypoplasia of the earlobes (HP:0009906)1.81792816
78Conjunctival hamartoma (HP:0100780)1.74467465
79Short tibia (HP:0005736)1.74071972
80Double outlet right ventricle (HP:0001719)1.73025572
81Congenital malformation of the right heart (HP:0011723)1.73025572
82Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.71180624
83Abnormality of the pupil (HP:0000615)1.69584618
84Hyperkalemia (HP:0002153)1.69164509
85Torticollis (HP:0000473)1.69093190
86Abnormality of vitamin metabolism (HP:0100508)1.67425159
87Irregular vertebral endplates (HP:0003301)1.65799334
88Cholelithiasis (HP:0001081)1.65071545
89Abnormality of the phalanges of the 5th finger (HP:0004213)1.64196595
90Premature ovarian failure (HP:0008209)1.63535922
91Impulsivity (HP:0100710)1.62244567
92Abnormality of subcutaneous fat tissue (HP:0001001)1.62152928
93Spinal cord compression (HP:0002176)1.61281707
94Genu recurvatum (HP:0002816)1.60728229
95Aplasia/Hypoplasia of the tibia (HP:0005772)1.60638176
96Absent phalangeal crease (HP:0006109)1.60242133
97Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.59905495
98Asymmetric septal hypertrophy (HP:0001670)1.57881846
99Abnormality of the tricuspid valve (HP:0001702)1.57318757
100Asymmetry of the thorax (HP:0001555)1.57029006

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K137.15465010
2FRK6.12456888
3FGFR22.99488018
4MAP3K142.89552518
5CDK122.80431794
6STK162.46208104
7NEK12.20395773
8EIF2AK12.13215556
9CSNK1G32.04365446
10EEF2K2.00140435
11WEE11.88633779
12KDR1.87685771
13NME21.78998997
14CSNK1A1L1.75905097
15PLK41.72815760
16CSNK1G11.68955162
17BRD41.66550001
18CSNK1G21.60630634
19CDC71.59653786
20BCKDK1.48876032
21TAOK11.45808277
22PLK31.43201384
23PLK11.43151305
24SRPK11.41791898
25TAOK21.37317211
26ILK1.34715738
27MAPKAPK31.30517906
28IKBKB1.27353807
29NUAK11.26185440
30NEK21.25496782
31CHEK21.24268440
32TTK1.21670109
33ZAK1.19050957
34WNK11.16180518
35MKNK21.14943711
36CDK81.14135443
37ATR1.08220192
38CDK71.07293264
39AURKA1.04176494
40MAP2K30.99719925
41ARAF0.94180872
42MAP3K70.93857216
43RAF10.93522173
44BRSK20.93108050
45KSR20.90285644
46TRPM70.87774053
47FGFR30.87139432
48TRIB30.84641631
49STK110.82363845
50MAPKAPK50.80451797
51PRPF4B0.79614962
52RPS6KB20.77263908
53MAPK130.75728158
54WNK40.75594947
55MAP3K100.72653484
56STK40.71545986
57PBK0.68063630
58MAP3K90.67711380
59BUB10.66654279
60ACVR1B0.63114025
61CDK40.62202869
62ATM0.60983123
63BRSK10.60222224
64PKN20.57921041
65MOS0.55505973
66PRKD30.54070555
67MARK30.52838853
68PRKAA20.51717167
69TRIM280.46808367
70ERBB40.45972370
71CHUK0.45294059
72VRK20.43693905
73CCNB10.43622726
74VRK10.43022452
75TLK10.42989353
76SGK10.42911630
77MAPK110.42375076
78BMX0.42348005
79CDK20.41886967
80PAK10.40972304
81CSNK1A10.38901233
82CSNK2A10.37425706
83BRAF0.36153245
84KSR10.36076019
85MET0.34934604
86DYRK30.34385051
87MAPK120.33314051
88AKT20.31395570
89CHEK10.31264140
90CSNK2A20.30703528
91MAP3K80.30571321
92EPHA40.30205982
93EPHB20.29839579
94TAOK30.28283667
95NME10.27932966
96CSNK1D0.27433036
97SIK30.26184689
98TEC0.24164342
99PRKD20.23638940
100BMPR20.23611685

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009205.45105172
2Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005345.01977070
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.38951294
4Sulfur relay system_Homo sapiens_hsa041223.32464489
5Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.20370106
6Base excision repair_Homo sapiens_hsa034102.88613483
7DNA replication_Homo sapiens_hsa030302.82698621
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.67913442
9Homologous recombination_Homo sapiens_hsa034402.27661633
10Mismatch repair_Homo sapiens_hsa034302.18392151
11Basal transcription factors_Homo sapiens_hsa030222.16127866
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.09636525
13Collecting duct acid secretion_Homo sapiens_hsa049662.02583435
14Cysteine and methionine metabolism_Homo sapiens_hsa002701.90709084
15Fanconi anemia pathway_Homo sapiens_hsa034601.83497429
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.83275555
17One carbon pool by folate_Homo sapiens_hsa006701.77950979
18Fatty acid biosynthesis_Homo sapiens_hsa000611.69680654
19Proteasome_Homo sapiens_hsa030501.68922154
20Spliceosome_Homo sapiens_hsa030401.53691090
21Renin-angiotensin system_Homo sapiens_hsa046141.51327826
22Nucleotide excision repair_Homo sapiens_hsa034201.44279357
23Type II diabetes mellitus_Homo sapiens_hsa049301.40292677
24p53 signaling pathway_Homo sapiens_hsa041151.36605917
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.31703044
26RNA degradation_Homo sapiens_hsa030181.31681675
27Adipocytokine signaling pathway_Homo sapiens_hsa049201.31022459
28Glutathione metabolism_Homo sapiens_hsa004801.24529115
29Nitrogen metabolism_Homo sapiens_hsa009101.22063862
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21363653
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20180703
32RNA transport_Homo sapiens_hsa030131.16880903
33Tryptophan metabolism_Homo sapiens_hsa003801.15810853
34Fatty acid elongation_Homo sapiens_hsa000621.07093354
35Oxidative phosphorylation_Homo sapiens_hsa001901.06548285
36Pyrimidine metabolism_Homo sapiens_hsa002401.06309307
37RNA polymerase_Homo sapiens_hsa030201.01290759
38Other glycan degradation_Homo sapiens_hsa005111.00329189
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97043050
40Peroxisome_Homo sapiens_hsa041460.94532683
41Protein export_Homo sapiens_hsa030600.92441308
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91691712
43Ribosome_Homo sapiens_hsa030100.91532319
44Glycosaminoglycan degradation_Homo sapiens_hsa005310.89362823
45Maturity onset diabetes of the young_Homo sapiens_hsa049500.88668051
46Pyruvate metabolism_Homo sapiens_hsa006200.80636224
47Basal cell carcinoma_Homo sapiens_hsa052170.76657242
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74293262
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73509397
50Cell cycle_Homo sapiens_hsa041100.72923821
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71624053
52TGF-beta signaling pathway_Homo sapiens_hsa043500.69075156
53Non-homologous end-joining_Homo sapiens_hsa034500.65982112
54Biosynthesis of amino acids_Homo sapiens_hsa012300.64442869
55Hippo signaling pathway_Homo sapiens_hsa043900.60993789
56Synaptic vesicle cycle_Homo sapiens_hsa047210.60403724
57Fatty acid metabolism_Homo sapiens_hsa012120.57588020
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56798626
59Folate biosynthesis_Homo sapiens_hsa007900.55538427
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55515325
61Glycerolipid metabolism_Homo sapiens_hsa005610.54453809
62Purine metabolism_Homo sapiens_hsa002300.52575465
63Huntingtons disease_Homo sapiens_hsa050160.52216687
64Metabolic pathways_Homo sapiens_hsa011000.50483533
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48919911
66mRNA surveillance pathway_Homo sapiens_hsa030150.48805055
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42685272
68Endometrial cancer_Homo sapiens_hsa052130.42620316
69Retinol metabolism_Homo sapiens_hsa008300.42279944
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42130477
71N-Glycan biosynthesis_Homo sapiens_hsa005100.39938662
72Nicotine addiction_Homo sapiens_hsa050330.37944899
73MicroRNAs in cancer_Homo sapiens_hsa052060.36833071
74Carbon metabolism_Homo sapiens_hsa012000.36822317
75Parkinsons disease_Homo sapiens_hsa050120.36219168
76mTOR signaling pathway_Homo sapiens_hsa041500.36132965
77Colorectal cancer_Homo sapiens_hsa052100.35031185
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34410587
79Herpes simplex infection_Homo sapiens_hsa051680.33657348
80Insulin resistance_Homo sapiens_hsa049310.32034691
81Wnt signaling pathway_Homo sapiens_hsa043100.31689548
82Vitamin digestion and absorption_Homo sapiens_hsa049770.31493988
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29369369
84Insulin signaling pathway_Homo sapiens_hsa049100.28565861
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25897427
86Pentose phosphate pathway_Homo sapiens_hsa000300.25782051
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25434984
88Arginine and proline metabolism_Homo sapiens_hsa003300.23574519
89Vitamin B6 metabolism_Homo sapiens_hsa007500.22465243
90Oocyte meiosis_Homo sapiens_hsa041140.20910962
91Phototransduction_Homo sapiens_hsa047440.20419820
92FoxO signaling pathway_Homo sapiens_hsa040680.20233206
93Propanoate metabolism_Homo sapiens_hsa006400.19883215
94Notch signaling pathway_Homo sapiens_hsa043300.19665784
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.19266929
96Olfactory transduction_Homo sapiens_hsa047400.19050097
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.17552768
98Dorso-ventral axis formation_Homo sapiens_hsa043200.16583385
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16281294
100Fat digestion and absorption_Homo sapiens_hsa049750.16225851

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