ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	CENP-A containing nucleosome assembly (GO:0034080)	4.66391388
2	chromatin remodeling at centromere (GO:0031055)	4.51909753
3	DNA strand elongation involved in DNA replication (GO:0006271)	4.49548771
4	DNA replication initiation (GO:0006270)	4.44007891
5	DNA unwinding involved in DNA replication (GO:0006268)	4.35814716
6	DNA strand elongation (GO:0022616)	4.27060517
7	non-recombinational repair (GO:0000726)	4.25808246
8	double-strand break repair via nonhomologous end joining (GO:0006303)	4.25808246
9	DNA replication checkpoint (GO:0000076)	4.25328934
10	telomere maintenance via semi-conservative replication (GO:0032201)	4.24350711
11	DNA replication-independent nucleosome organization (GO:0034724)	4.19208953
12	DNA replication-independent nucleosome assembly (GO:0006336)	4.19208953
13	replication fork processing (GO:0031297)	4.09438864
14	mitotic metaphase plate congression (GO:0007080)	4.01808740
15	nucleobase biosynthetic process (GO:0046112)	3.96981955
16	purine nucleobase biosynthetic process (GO:0009113)	3.94321457
17	protein localization to kinetochore (GO:0034501)	3.87321968
18	nuclear pore organization (GO:0006999)	3.85363820
19	nuclear pore complex assembly (GO:0051292)	3.84805837
20	telomere maintenance via recombination (GO:0000722)	3.84803149
21	mitotic recombination (GO:0006312)	3.81762699
22	kinetochore organization (GO:0051383)	3.76538409
23	histone exchange (GO:0043486)	3.76253999
24	proteasome assembly (GO:0043248)	3.73051560
25	mitotic sister chromatid segregation (GO:0000070)	3.71179921
26	mitotic chromosome condensation (GO:0007076)	3.65499078
27	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.64576167
28	establishment of integrated proviral latency (GO:0075713)	3.63126280
29	metaphase plate congression (GO:0051310)	3.63118002
30	IMP biosynthetic process (GO:0006188)	3.59618344
31	ribosomal small subunit assembly (GO:0000028)	3.56950132
32	sister chromatid segregation (GO:0000819)	3.55412949
33	regulation of spindle organization (GO:0090224)	3.55272756
34	DNA replication-dependent nucleosome organization (GO:0034723)	3.49165409
35	DNA replication-dependent nucleosome assembly (GO:0006335)	3.49165409
36	negative regulation of fibroblast apoptotic process (GO:2000270)	3.48045409
37	nucleotide-excision repair, DNA gap filling (GO:0006297)	3.47393862
38	ribosome assembly (GO:0042255)	3.45103752
39	mitotic nuclear envelope disassembly (GO:0007077)	3.42629165
40	telomere maintenance via telomere lengthening (GO:0010833)	3.42173547
41	mitochondrial DNA replication (GO:0006264)	3.41212570
42	attachment of spindle microtubules to kinetochore (GO:0008608)	3.41156136
43	mitotic sister chromatid cohesion (GO:0007064)	3.39324493
44	establishment of chromosome localization (GO:0051303)	3.38094244
45	protein localization to chromosome, centromeric region (GO:0071459)	3.37178214
46	protein K6-linked ubiquitination (GO:0085020)	3.31129728
47	kinetochore assembly (GO:0051382)	3.28378806
48	DNA ligation (GO:0006266)	3.27461007
49	folic acid-containing compound biosynthetic process (GO:0009396)	3.25994895
50	translesion synthesis (GO:0019985)	3.23913163
51	maturation of SSU-rRNA (GO:0030490)	3.22882528
52	mitochondrial RNA metabolic process (GO:0000959)	3.22370534
53	viral mRNA export from host cell nucleus (GO:0046784)	3.21046710
54	DNA-dependent DNA replication (GO:0006261)	3.19698494
55	ribosome biogenesis (GO:0042254)	3.17370702
56	resolution of meiotic recombination intermediates (GO:0000712)	3.16890681
57	spindle checkpoint (GO:0031577)	3.16849830
58	negative regulation of mitotic sister chromatid separation (GO:2000816)	3.12833516
59	negative regulation of mitotic sister chromatid segregation (GO:0033048)	3.12833516
60	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	3.12833516
61	negative regulation of sister chromatid segregation (GO:0033046)	3.12833516
62	chromatin assembly or disassembly (GO:0006333)	3.12775481
63	membrane disassembly (GO:0030397)	3.12473669
64	nuclear envelope disassembly (GO:0051081)	3.12473669
65	pseudouridine synthesis (GO:0001522)	3.12359042
66	spindle assembly checkpoint (GO:0071173)	3.11437150
67	rRNA modification (GO:0000154)	3.11151373
68	negative regulation of chromosome segregation (GO:0051985)	3.10041041
69	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.08720146
70	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.08720146
71	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.08720146
72	cullin deneddylation (GO:0010388)	3.08423334
73	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.07889592
74	pore complex assembly (GO:0046931)	3.07153896
75	IMP metabolic process (GO:0046040)	3.07091801
76	mitotic spindle assembly checkpoint (GO:0007094)	3.06487589
77	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.05907356
78	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.05386403
79	regulation of centrosome cycle (GO:0046605)	3.03742901
80	regulation of mitotic metaphase/anaphase transition (GO:0030071)	3.03502524
81	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	3.02953736
82	chromosome segregation (GO:0007059)	3.02429643
83	rRNA methylation (GO:0031167)	3.01947466
84	ATP-dependent chromatin remodeling (GO:0043044)	3.01885199
85	meiotic chromosome segregation (GO:0045132)	3.01797519
86	DNA catabolic process, exonucleolytic (GO:0000738)	2.99495663
87	regulation of mitotic sister chromatid segregation (GO:0033047)	2.97704145
88	regulation of sister chromatid segregation (GO:0033045)	2.97704145
89	regulation of mitotic sister chromatid separation (GO:0010965)	2.97704145
90	postreplication repair (GO:0006301)	2.97618386
91	spliceosomal complex assembly (GO:0000245)	2.97202221
92	mitotic spindle checkpoint (GO:0071174)	2.97165896
93	* somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.97088006
94	* somatic hypermutation of immunoglobulin genes (GO:0016446)	2.97088006
95	regulation of chromosome segregation (GO:0051983)	2.96993223
96	histone H2A acetylation (GO:0043968)	2.96307169
97	regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	2.96080216
98	amino acid activation (GO:0043038)	2.95716897
99	tRNA aminoacylation (GO:0043039)	2.95716897
100	tRNA aminoacylation for protein translation (GO:0006418)	2.95511348
101	histone mRNA metabolic process (GO:0008334)	2.95303929
102	DNA double-strand break processing (GO:0000729)	2.94508944
103	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.93597456
104	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.93597456
105	isotype switching (GO:0045190)	2.93597456
106	telomere maintenance (GO:0000723)	2.93232437
107	telomere organization (GO:0032200)	2.93015667
108	DNA topological change (GO:0006265)	2.92160154
109	ribonucleoprotein complex biogenesis (GO:0022613)	2.91668603
110	lactate metabolic process (GO:0006089)	2.91597887
111	spliceosomal snRNP assembly (GO:0000387)	2.91331554
112	rRNA processing (GO:0006364)	2.90442402
113	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.90383640
114	L-serine metabolic process (GO:0006563)	2.90283000
115	* mismatch repair (GO:0006298)	2.89209425
116	protein deneddylation (GO:0000338)	2.89013266
117	regulation of centrosome duplication (GO:0010824)	2.89012545
118	formation of translation preinitiation complex (GO:0001731)	2.88952780
119	recombinational repair (GO:0000725)	2.88017721
120	double-strand break repair via homologous recombination (GO:0000724)	2.87811655
121	DNA duplex unwinding (GO:0032508)	2.87499666
122	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.86734367
123	DNA geometric change (GO:0032392)	2.86418279
124	intra-S DNA damage checkpoint (GO:0031573)	2.84832607
125	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.84462826
126	regulation of mitotic spindle checkpoint (GO:1903504)	2.84462826
127	regulation of centriole replication (GO:0046599)	2.84212724
128	regulation of DNA endoreduplication (GO:0032875)	2.84128725
129	transcription-coupled nucleotide-excision repair (GO:0006283)	2.82851458
130	base-excision repair (GO:0006284)	2.82807512
131	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	2.82296855
132	mitochondrial DNA metabolic process (GO:0032042)	2.81808993
133	snRNA processing (GO:0016180)	2.78265156
134	tetrahydrofolate metabolic process (GO:0046653)	2.75139909
135	double-strand break repair (GO:0006302)	2.75050072
136	* somatic recombination of immunoglobulin gene segments (GO:0016447)	2.74169975
137	cytoplasmic mRNA processing body assembly (GO:0033962)	2.73819139
138	* somatic diversification of immunoglobulins (GO:0016445)	2.71719127
139	positive regulation of chromosome segregation (GO:0051984)	2.69083462
140	DNA damage response, detection of DNA damage (GO:0042769)	2.68682790

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXM1_23109430_ChIP-Seq_U2OS_Human	4.52325787
2	E2F4_17652178_ChIP-ChIP_JURKAT_Human	4.37668517
3	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.82928546
4	* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	3.45809534
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.36533686
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.02664188
7	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.84197699
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.84069870
9	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.72257187
10	* MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.68377532
11	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.66900481
12	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.61694755
13	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.60384931
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.56301427
15	* MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.51116059
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.47808241
17	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.35193920
18	VDR_23849224_ChIP-Seq_CD4+_Human	2.34852847
19	E2F1_21310950_ChIP-Seq_MCF-7_Human	2.34308481
20	* KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.32163920
21	* CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.30870273
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.26321728
23	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.24281045
24	FOXP3_21729870_ChIP-Seq_TREG_Human	2.22654216
25	* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	2.17041370
26	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.16636541
27	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.15549352
28	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.12184379
29	XRN2_22483619_ChIP-Seq_HELA_Human	2.06722773
30	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.02361457
31	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.00772748
32	E2F7_22180533_ChIP-Seq_HELA_Human	10.3181679
33	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.95940523
34	ELK1_19687146_ChIP-ChIP_HELA_Human	1.86098586
35	CIITA_25753668_ChIP-Seq_RAJI_Human	1.84432299
36	* MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.83776338
37	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.82799575
38	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.81409347
39	* GABP_19822575_ChIP-Seq_HepG2_Human	1.78720435
40	* HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.77798890
41	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.77477481
42	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.77269361
43	TTF2_22483619_ChIP-Seq_HELA_Human	1.75385598
44	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.74175686
45	AR_21909140_ChIP-Seq_LNCAP_Human	1.69835870
46	DCP1A_22483619_ChIP-Seq_HELA_Human	1.66431641
47	TAF15_26573619_Chip-Seq_HEK293_Human	1.64528958
48	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.62421816
49	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.59724339
50	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.59545494
51	* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.54584223
52	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.54543675
53	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.52505389
54	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.52476000
55	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.49031164
56	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.45068778
57	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.43505043
58	* SRF_21415370_ChIP-Seq_HL-1_Mouse	1.38631346
59	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.38480424
60	* TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.37616771
61	ZNF274_21170338_ChIP-Seq_K562_Hela	1.36152458
62	KDM5A_27292631_Chip-Seq_BREAST_Human	1.35875643
63	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.34758385
64	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.34066068
65	MYC_22102868_ChIP-Seq_BL_Human	1.31125221
66	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.29512087
67	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.26899764
68	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.25390191
69	* ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.23186299
70	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.22216390
71	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.22083186
72	* CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.21226843
73	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.19545353
74	MYC_18940864_ChIP-ChIP_HL60_Human	1.14097724
75	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.12341451
76	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.09735420
77	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.09006960
78	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.03134092
79	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.02935354
80	ELF5_23300383_ChIP-Seq_T47D_Human	1.02528060
81	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.02307805
82	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.00300374
83	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.99731161
84	ER_23166858_ChIP-Seq_MCF-7_Human	0.99447447
85	IRF1_19129219_ChIP-ChIP_H3396_Human	0.99436301
86	* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.99386993
87	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.99300432
88	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.97373392
89	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.97329302
90	SOX9_26525672_Chip-Seq_HEART_Mouse	0.96861464
91	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.96826229
92	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.95918069
93	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.95527283
94	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.94910582
95	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.94392966
96	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.94288549
97	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.93338209
98	EWS_26573619_Chip-Seq_HEK293_Human	0.92773890
99	P300_19829295_ChIP-Seq_ESCs_Human	0.92611086
100	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.92072596
101	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.91272777
102	CHD1_26751641_Chip-Seq_LNCaP_Human	0.89712548
103	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.89082906
104	VDR_22108803_ChIP-Seq_LS180_Human	0.88684998
105	FUS_26573619_Chip-Seq_HEK293_Human	0.88308527
106	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.87994238
107	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.86851606
108	TFEB_21752829_ChIP-Seq_HELA_Human	0.86827713
109	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.86617097
110	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.84005215
111	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.82646305
112	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.81838675
113	SPI1_23547873_ChIP-Seq_NB4_Human	0.81512764
114	NANOG_21062744_ChIP-ChIP_HESCs_Human	0.80709083
115	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.79688791
116	TP53_22573176_ChIP-Seq_HFKS_Human	0.77510899
117	CBP_20019798_ChIP-Seq_JUKART_Human	0.77389401
118	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.77389401
119	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.76738817
120	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.73825482
121	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.73605467
122	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.72895814
123	IGF1R_20145208_ChIP-Seq_DFB_Human	0.72013084
124	* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.70853233
125	* PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.70644760
126	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.69917302
127	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.66565386
128	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	0.66233247

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	4.87552416
2	* MP0010094_abnormal_chromosome_stability	4.44428302
3	MP0003693_abnormal_embryo_hatching	4.39022855
4	* MP0003111_abnormal_nucleus_morphology	4.02231729
5	MP0003077_abnormal_cell_cycle	3.81243451
6	MP0008877_abnormal_DNA_methylation	3.69249215
7	MP0008007_abnormal_cellular_replicative	3.49682494
8	MP0004957_abnormal_blastocyst_morpholog	3.41970622
9	* MP0008058_abnormal_DNA_repair	3.17206635
10	MP0002396_abnormal_hematopoietic_system	2.89126447
11	MP0003121_genomic_imprinting	2.85659451
12	MP0003787_abnormal_imprinting	2.71813293
13	MP0003123_paternal_imprinting	2.67905663
14	MP0000372_irregular_coat_pigmentation	2.56417424
15	MP0008932_abnormal_embryonic_tissue	2.37442681
16	MP0004233_abnormal_muscle_weight	2.18572069
17	MP0006035_abnormal_mitochondrial_morpho	2.04958010
18	MP0005408_hypopigmentation	1.91722534
19	MP0000350_abnormal_cell_proliferation	1.89889559
20	MP0004808_abnormal_hematopoietic_stem	1.87859851
21	MP0002234_abnormal_pharynx_morphology	1.86287301
22	MP0002163_abnormal_gland_morphology	1.82638297
23	MP0003763_abnormal_thymus_physiology	1.82253789
24	MP0003122_maternal_imprinting	1.80455900
25	MP0003786_premature_aging	1.77916580
26	MP0001188_hyperpigmentation	1.75920766
27	MP0000427_abnormal_hair_cycle	1.71616422
28	MP0004147_increased_porphyrin_level	1.71296267
29	MP0001730_embryonic_growth_arrest	1.69232894
30	MP0000383_abnormal_hair_follicle	1.58274707
31	MP0002009_preneoplasia	1.52577876
32	MP0005379_endocrine/exocrine_gland_phen	1.51223261
33	MP0003890_abnormal_embryonic-extraembry	1.47375475
34	MP0006292_abnormal_olfactory_placode	1.46930738
35	MP0000703_abnormal_thymus_morphology	1.46354025
36	MP0001697_abnormal_embryo_size	1.42114825
37	MP0005380_embryogenesis_phenotype	1.38304459
38	MP0001672_abnormal_embryogenesis/_devel	1.38304459
39	MP0001529_abnormal_vocalization	1.32902381
40	MP0010307_abnormal_tumor_latency	1.30985572
41	MP0000490_abnormal_crypts_of	1.28252695
42	* MP0002398_abnormal_bone_marrow	1.27659362
43	MP0002085_abnormal_embryonic_tissue	1.25206205
44	MP0002080_prenatal_lethality	1.24500783
45	MP0009333_abnormal_splenocyte_physiolog	1.23566393
46	MP0003984_embryonic_growth_retardation	1.22829123
47	MP0010678_abnormal_skin_adnexa	1.22706189
48	MP0000313_abnormal_cell_death	1.21831845
49	MP0003880_abnormal_central_pattern	1.19977667
50	MP0002088_abnormal_embryonic_growth/wei	1.18983047
51	MP0003315_abnormal_perineum_morphology	1.18172595
52	MP0001661_extended_life_span	1.15286464
53	MP0010352_gastrointestinal_tract_polyps	1.14180774
54	MP0009697_abnormal_copulation	1.12577386
55	MP0002938_white_spotting	1.12073552
56	MP0002084_abnormal_developmental_patter	1.08963717
57	MP0002086_abnormal_extraembryonic_tissu	1.07810376
58	MP0002090_abnormal_vision	1.07750629
59	MP0005253_abnormal_eye_physiology	1.07485025
60	* MP0002210_abnormal_sex_determination	1.06183066
61	MP0003943_abnormal_hepatobiliary_system	1.05798604
62	MP0002095_abnormal_skin_pigmentation	1.05401512
63	MP0000569_abnormal_digit_pigmentation	1.04523435
64	MP0000015_abnormal_ear_pigmentation	1.03945070
65	MP0002722_abnormal_immune_system	1.03174944
66	* MP0002019_abnormal_tumor_incidence	1.01930993
67	MP0000689_abnormal_spleen_morphology	1.01509601
68	MP0001293_anophthalmia	0.98061569
69	MP0000428_abnormal_craniofacial_morphol	0.95079905
70	MP0005671_abnormal_response_to	0.94107002
71	MP0003567_abnormal_fetal_cardiomyocyte	0.93657463
72	MP0004197_abnormal_fetal_growth/weight/	0.91468064
73	MP0000613_abnormal_salivary_gland	0.90512635
74	MP0003646_muscle_fatigue	0.90039369
75	MP0004084_abnormal_cardiac_muscle	0.89905291
76	MP0002160_abnormal_reproductive_system	0.89672625
77	* MP0001145_abnormal_male_reproductive	0.87744315
78	MP0002102_abnormal_ear_morphology	0.87241697
79	MP0001346_abnormal_lacrimal_gland	0.87180664
80	MP0009672_abnormal_birth_weight	0.87169526
81	MP0000631_abnormal_neuroendocrine_gland	0.86724824
82	* MP0002429_abnormal_blood_cell	0.86603662
83	MP0005389_reproductive_system_phenotype	0.85880590
84	MP0005220_abnormal_exocrine_pancreas	0.85605112
85	MP0005083_abnormal_biliary_tract	0.85455451
86	MP0000647_abnormal_sebaceous_gland	0.84727927
87	MP0001764_abnormal_homeostasis	0.84505335
88	MP0006072_abnormal_retinal_apoptosis	0.84197703
89	MP0000371_diluted_coat_color	0.83693395
90	MP0006054_spinal_hemorrhage	0.83424422
91	* MP0001929_abnormal_gametogenesis	0.83271319
92	MP0005397_hematopoietic_system_phenotyp	0.82872527
93	MP0001545_abnormal_hematopoietic_system	0.82872527
94	MP0005367_renal/urinary_system_phenotyp	0.82813306
95	MP0000516_abnormal_urinary_system	0.82813306
96	MP0001119_abnormal_female_reproductive	0.81767689
97	MP0003937_abnormal_limbs/digits/tail_de	0.81483230
98	MP0005391_vision/eye_phenotype	0.81293605
99	MP0005171_absent_coat_pigmentation	0.81284951
100	* MP0000653_abnormal_sex_gland	0.80146502
101	MP0001324_abnormal_eye_pigmentation	0.79146061
102	MP0005646_abnormal_pituitary_gland	0.78534814
103	MP0002233_abnormal_nose_morphology	0.77627900
104	MP0001286_abnormal_eye_development	0.77292136
105	MP0004133_heterotaxia	0.77205576
106	MP0003755_abnormal_palate_morphology	0.76842386
107	* MP0000716_abnormal_immune_system	0.76237443
108	MP0005174_abnormal_tail_pigmentation	0.76127540
109	* MP0005384_cellular_phenotype	0.75878926
110	MP0006036_abnormal_mitochondrial_physio	0.75697397
111	MP0009780_abnormal_chondrocyte_physiolo	0.75656435
112	MP0010030_abnormal_orbit_morphology	0.75056226
113	MP0003861_abnormal_nervous_system	0.74985334
114	MP0003186_abnormal_redox_activity	0.74170693
115	MP0005248_abnormal_Harderian_gland	0.73867895
116	MP0009703_decreased_birth_body	0.73397212
117	MP0002822_catalepsy	0.73081136
118	MP0002751_abnormal_autonomic_nervous	0.73021251
119	MP0002098_abnormal_vibrissa_morphology	0.72421770
120	MP0001186_pigmentation_phenotype	0.71922704
121	MP0005395_other_phenotype	0.71844147
122	MP0002928_abnormal_bile_duct	0.71838258
123	MP0003718_maternal_effect	0.70121280
124	MP0001919_abnormal_reproductive_system	0.67984278
125	MP0001800_abnormal_humoral_immune	0.66654006
126	MP0002114_abnormal_axial_skeleton	0.63099812
127	* MP0005621_abnormal_cell_physiology	0.61546082
128	* MP0002420_abnormal_adaptive_immunity	0.61537413
129	MP0005075_abnormal_melanosome_morpholog	0.61529375
130	MP0000778_abnormal_nervous_system	0.61103779
131	MP0009379_abnormal_foot_pigmentation	0.60847240
132	MP0005409_darkened_coat_color	0.60663070
133	MP0002736_abnormal_nociception_after	0.60447922
134	MP0002111_abnormal_tail_morphology	0.59050661
135	* MP0001819_abnormal_immune_cell	0.58226053
136	MP0005076_abnormal_cell_differentiation	0.56084153
137	MP0000358_abnormal_cell_content/	0.55102836
138	MP0003935_abnormal_craniofacial_develop	0.54524433
139	* MP0003698_abnormal_male_reproductive	0.53884878
140	MP0003115_abnormal_respiratory_system	0.52829258
141	MP0002075_abnormal_coat/hair_pigmentati	0.52530435
142	MP0000465_gastrointestinal_hemorrhage	0.51990813
143	MP0003119_abnormal_digestive_system	0.51660250

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Birth length less than 3rd percentile (HP:0003561)	5.50610488
2	Chromsome breakage (HP:0040012)	4.21440380
3	Chromosomal breakage induced by crosslinking agents (HP:0003221)	4.06452879
4	Meckel diverticulum (HP:0002245)	3.41686131
5	Prostate neoplasm (HP:0100787)	3.40799293
6	Abnormality of chromosome stability (HP:0003220)	3.33183765
7	Abnormality of the ileum (HP:0001549)	3.27342905
8	Abnormality of the preputium (HP:0100587)	3.22785322
9	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.22767421
10	Patellar aplasia (HP:0006443)	3.22065024
11	Abnormality of the labia minora (HP:0012880)	3.03157012
12	Supernumerary spleens (HP:0009799)	2.99448657
13	Abnormal lung lobation (HP:0002101)	2.97793425
14	Aplasia/Hypoplasia of the patella (HP:0006498)	2.97370336
15	Breast hypoplasia (HP:0003187)	2.94677925
16	Aplastic anemia (HP:0001915)	2.91369834
17	Colon cancer (HP:0003003)	2.90872551
18	Cerebellar dysplasia (HP:0007033)	2.86295864
19	Myelodysplasia (HP:0002863)	2.79157941
20	Volvulus (HP:0002580)	2.75861542
21	Nephroblastoma (Wilms tumor) (HP:0002667)	2.74797777
22	Duodenal stenosis (HP:0100867)	2.71902835
23	Small intestinal stenosis (HP:0012848)	2.71902835
24	Papillary thyroid carcinoma (HP:0002895)	2.71890701
25	* Medulloblastoma (HP:0002885)	2.65771123
26	Abnormality of methionine metabolism (HP:0010901)	2.64050089
27	Ectopic kidney (HP:0000086)	2.62650762
28	Cerebral hypomyelination (HP:0006808)	2.59342607
29	Abnormality of the prostate (HP:0008775)	2.59260179
30	Embryonal renal neoplasm (HP:0011794)	2.57565111
31	Reticulocytopenia (HP:0001896)	2.54870947
32	Asplenia (HP:0001746)	2.49565527
33	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.46325702
34	11 pairs of ribs (HP:0000878)	2.45353892
35	Anterior segment dysgenesis (HP:0007700)	2.41455912
36	* Agnosia (HP:0010524)	2.41349229
37	Bone marrow hypocellularity (HP:0005528)	2.41263855
38	Acute lymphatic leukemia (HP:0006721)	2.39952676
39	Hypoplastic pelvis (HP:0008839)	2.36392607
40	Optic nerve coloboma (HP:0000588)	2.36205791
41	Sloping forehead (HP:0000340)	2.35222191
42	Renal cortical cysts (HP:0000803)	2.34791556
43	* Astrocytoma (HP:0009592)	2.33384052
44	* Abnormality of the astrocytes (HP:0100707)	2.33384052
45	Small hand (HP:0200055)	2.33259832
46	* Glioma (HP:0009733)	2.29755497
47	Abnormality of the renal cortex (HP:0011035)	2.28395288
48	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.27462915
49	Short 4th metacarpal (HP:0010044)	2.27462915
50	Abnormal number of incisors (HP:0011064)	2.27167235
51	Thyroid carcinoma (HP:0002890)	2.26364419
52	3-Methylglutaconic aciduria (HP:0003535)	2.24386808
53	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.24117140
54	Limb hypertonia (HP:0002509)	2.23036407
55	Increased serum lactate (HP:0002151)	2.22099376
56	Abnormality of the duodenum (HP:0002246)	2.21220604
57	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.17793041
58	Abnormality of the carotid arteries (HP:0005344)	2.13851955
59	Clubbing of toes (HP:0100760)	2.11482978
60	Abnormality of glycolysis (HP:0004366)	2.05654420
61	Absent thumb (HP:0009777)	2.04520176
62	Premature graying of hair (HP:0002216)	2.04386351
63	Increased nuchal translucency (HP:0010880)	2.03108630
64	Degeneration of anterior horn cells (HP:0002398)	2.02025670
65	Abnormality of the anterior horn cell (HP:0006802)	2.02025670
66	Acute myeloid leukemia (HP:0004808)	1.98428925
67	Pheochromocytoma (HP:0002666)	1.98303433
68	Tented upper lip vermilion (HP:0010804)	1.98176136
69	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.95822796
70	Tubulointerstitial nephritis (HP:0001970)	1.94714430
71	Pancreatic cysts (HP:0001737)	1.94642960
72	Impulsivity (HP:0100710)	1.94607528
73	Gonadotropin excess (HP:0000837)	1.94460035
74	Abnormal number of erythroid precursors (HP:0012131)	1.93742673
75	Triphalangeal thumb (HP:0001199)	1.93738045
76	Selective tooth agenesis (HP:0001592)	1.93398232
77	* Lymphoma (HP:0002665)	1.91645452
78	Abnormality of alanine metabolism (HP:0010916)	1.89889421
79	Hyperalaninemia (HP:0003348)	1.89889421
80	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.89889421
81	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.88913732
82	Hepatic necrosis (HP:0002605)	1.88130611
83	Abnormality of cells of the erythroid lineage (HP:0012130)	1.88041558
84	Increased serum pyruvate (HP:0003542)	1.86682061
85	Acute encephalopathy (HP:0006846)	1.86600089
86	Horseshoe kidney (HP:0000085)	1.86460643
87	* Cafe-au-lait spot (HP:0000957)	1.85534924
88	Absent radius (HP:0003974)	1.84674805
89	Squamous cell carcinoma (HP:0002860)	1.83927769
90	Neuroendocrine neoplasm (HP:0100634)	1.79987053
91	Increased CSF lactate (HP:0002490)	1.79339515
92	Astigmatism (HP:0000483)	1.78598941
93	Lissencephaly (HP:0001339)	1.77970576
94	Postnatal microcephaly (HP:0005484)	1.76381813
95	Proximal placement of thumb (HP:0009623)	1.76057190
96	Slender long bone (HP:0003100)	1.75476328
97	Toxemia of pregnancy (HP:0100603)	1.74794513
98	Progressive inability to walk (HP:0002505)	1.74662024
99	Deviation of the thumb (HP:0009603)	1.74176394
100	Oral leukoplakia (HP:0002745)	1.74019678
101	Abnormality of the fingertips (HP:0001211)	1.73888142
102	Horizontal nystagmus (HP:0000666)	1.73784021
103	Atresia of the external auditory canal (HP:0000413)	1.73441200
104	* Rhabdomyosarcoma (HP:0002859)	1.72967291
105	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.72603393
106	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.72603393
107	Hyperventilation (HP:0002883)	1.72058166
108	Microtia (HP:0008551)	1.71450816
109	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.71104736
110	Homocystinuria (HP:0002156)	1.70982246
111	Abnormality of homocysteine metabolism (HP:0010919)	1.70982246
112	High anterior hairline (HP:0009890)	1.70602276
113	* Amaurosis fugax (HP:0100576)	1.69350591
114	Aplasia involving forearm bones (HP:0009822)	1.69234462
115	Absent forearm bone (HP:0003953)	1.69234462
116	* Neoplasm of the colon (HP:0100273)	1.68393622
117	Abnormal hair whorl (HP:0010721)	1.68042328
118	Cellular immunodeficiency (HP:0005374)	1.67196889
119	Neoplasm of the adrenal gland (HP:0100631)	1.66989483
120	Tracheoesophageal fistula (HP:0002575)	1.66977264
121	Hyperglycinuria (HP:0003108)	1.66927017
122	* Ependymoma (HP:0002888)	1.66855699
123	Duplicated collecting system (HP:0000081)	1.66679142
124	Abnormal auditory evoked potentials (HP:0006958)	1.66556445
125	Deep philtrum (HP:0002002)	1.66023535
126	Breast carcinoma (HP:0003002)	1.66015970
127	Prominent nose (HP:0000448)	1.65981747
128	Type II lissencephaly (HP:0007260)	1.65688167
129	Microretrognathia (HP:0000308)	1.65594151
130	Supernumerary bones of the axial skeleton (HP:0009144)	1.65445163
131	Cerebral edema (HP:0002181)	1.64361950
132	Chronic hepatic failure (HP:0100626)	1.63445696
133	Microvesicular hepatic steatosis (HP:0001414)	1.62296108
134	CNS hypomyelination (HP:0003429)	1.61490700
135	Neoplasm of the adrenal cortex (HP:0100641)	1.61395916
136	Small for gestational age (HP:0001518)	1.61393828
137	Embryonal neoplasm (HP:0002898)	1.61373372
138	Methylmalonic acidemia (HP:0002912)	1.60911662
139	Cutaneous melanoma (HP:0012056)	1.60845768
140	Tongue fasciculations (HP:0001308)	1.60218109
141	Carpal bone hypoplasia (HP:0001498)	1.60056581
142	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.58830371
143	Absent epiphyses (HP:0010577)	1.58830371
144	Microglossia (HP:0000171)	1.58548859
145	Overlapping toe (HP:0001845)	1.58367508
146	* Freckling (HP:0001480)	1.58353587
147	Type I transferrin isoform profile (HP:0003642)	1.57725063
148	Short thumb (HP:0009778)	1.57233608
149	Progressive external ophthalmoplegia (HP:0000590)	1.56285738
150	Lactic acidosis (HP:0003128)	1.56018438
151	Supernumerary ribs (HP:0005815)	1.55830238
152	Meningioma (HP:0002858)	1.55418818
153	Hepatocellular necrosis (HP:0001404)	1.55417740
154	Pancreatic fibrosis (HP:0100732)	1.54127654
155	Macrocytic anemia (HP:0001972)	1.53521311
156	Protruding tongue (HP:0010808)	1.52142711
157	High pitched voice (HP:0001620)	1.51178389
158	Breast aplasia (HP:0100783)	1.50034929
159	* Neoplasm of the pancreas (HP:0002894)	1.49645813
160	Intestinal atresia (HP:0011100)	1.49564345
161	Preaxial hand polydactyly (HP:0001177)	1.49141884

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDC7	4.48194124
2	PIK3CG	3.50317429
3	BUB1	3.46632364
4	WEE1	3.42083027
5	TRIM28	3.40601445
6	SRPK1	3.28319015
7	TSSK6	3.00645217
8	EIF2AK1	2.65026424
9	BRSK2	2.62612606
10	CCNB1	2.30037546
11	FRK	2.26801845
12	PBK	2.22844767
13	VRK1	2.15998192
14	MKNK1	2.09267607
15	PLK4	2.08308752
16	NEK2	2.06636671
17	BRSK1	1.93825214
18	SIK3	1.93795740
19	NUAK1	1.91414079
20	ERBB3	1.89613342
21	TAF1	1.88574917
22	MKNK2	1.85264419
23	PLK3	1.82852922
24	PLK1	1.80584616
25	ATR	1.76290997
26	EPHA4	1.72555496
27	TLK1	1.71355765
28	LATS1	1.58538690
29	PDK2	1.58336229
30	NME1	1.57643959
31	PASK	1.57570882
32	CDK8	1.55270031
33	TTK	1.54468380
34	MAP3K10	1.54286280
35	VRK2	1.53586494
36	BMPR1B	1.46835558
37	CDK7	1.46772639
38	FLT3	1.42963209
39	TNIK	1.41872392
40	EEF2K	1.41831722
41	CDK12	1.40768548
42	STK16	1.40036567
43	AURKB	1.36451355
44	CHEK2	1.35976904
45	BRD4	1.32235409
46	WNK3	1.30916018
47	CHEK1	1.29148915
48	TXK	1.28438011
49	NEK1	1.26972031
50	CASK	1.24765695
51	DYRK3	1.23250854
52	CLK1	1.15883520
53	EIF2AK3	1.15442741
54	RPS6KB2	1.13525151
55	KIT	1.12095630
56	PRPF4B	1.08158267
57	MAP4K2	1.07562596
58	STK3	1.07351724
59	NEK6	1.03578526
60	YES1	1.03176919
61	ATM	1.02893113
62	PNCK	0.99102022
63	AURKA	0.98742595
64	ACVR1B	0.98176711
65	MAP3K4	0.97612207
66	ZAK	0.90102187
67	PRKD3	0.89771042
68	PLK2	0.89707810
69	CDK4	0.88047454
70	MAP4K1	0.87921759
71	MAPK13	0.86046229
72	BMPR2	0.84583444
73	CDK2	0.81542633
74	STK4	0.81023265
75	ERBB4	0.79279684
76	CDK1	0.75622792
77	AKT3	0.75441597
78	TEC	0.75234966
79	DAPK1	0.74354295
80	STK10	0.70757110
81	SGK2	0.67995373
82	MAP3K8	0.67760122
83	EIF2AK2	0.65173026
84	MST1R	0.64723534
85	CSNK1A1L	0.62702285
86	RPS6KB1	0.61997293
87	PIK3CA	0.61525842
88	STK39	0.61241382
89	ADRBK2	0.60903206
90	INSRR	0.60801925
91	TGFBR1	0.59064863
92	CSNK2A2	0.58571702
93	FER	0.58255608
94	NME2	0.56842044
95	CSNK1G1	0.56618235
96	PAK3	0.56071907
97	PIM1	0.56003498
98	MELK	0.54850310
99	ITK	0.52504742
100	BTK	0.51977661
101	GRK6	0.51904723
102	CSF1R	0.51553771
103	BRAF	0.51077477
104	CDK19	0.50306160
105	TAOK2	0.50209283
106	MAP3K12	0.49549413
107	STK38L	0.49029437
108	MET	0.48524943
109	CSNK2A1	0.47588619
110	MARK3	0.47291286
111	PRKCE	0.47103475
112	PRKCI	0.46437654
113	CSNK1E	0.45976855
114	STK24	0.45165823
115	RPS6KL1	0.44403585
116	RPS6KC1	0.44403585
117	MAP3K14	0.42279958
118	GRK1	0.41812206
119	MUSK	0.40546643
120	RPS6KA4	0.39928908
121	PHKG2	0.39838382
122	PHKG1	0.39838382
123	BCR	0.38827656
124	RPS6KA6	0.37879879
125	PAK4	0.37671762
126	RPS6KA5	0.36995131
127	CSNK1G3	0.36715208
128	KSR1	0.36713635
129	MAP2K7	0.36159919
130	TESK2	0.36059533
131	PRKDC	0.35708241
132	MST4	0.33255825
133	CAMK1D	0.31161106
134	MAPK14	0.30043237
135	SYK	0.28125253
136	LCK	0.27560960
137	ALK	0.27557260
138	SCYL2	0.27103403

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	4.69416506
2	* Mismatch repair_Homo sapiens_hsa03430	4.12295304
3	Homologous recombination_Homo sapiens_hsa03440	3.15977828
4	Base excision repair_Homo sapiens_hsa03410	3.13430207
5	Spliceosome_Homo sapiens_hsa03040	3.12907098
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.09908804
7	Cell cycle_Homo sapiens_hsa04110	2.90131032
8	RNA polymerase_Homo sapiens_hsa03020	2.85247369
9	Nucleotide excision repair_Homo sapiens_hsa03420	2.77869942
10	RNA transport_Homo sapiens_hsa03013	2.72603480
11	* Fanconi anemia pathway_Homo sapiens_hsa03460	2.63223975
12	Ribosome_Homo sapiens_hsa03010	2.39181532
13	Non-homologous end-joining_Homo sapiens_hsa03450	2.35320564
14	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.20408357
15	Proteasome_Homo sapiens_hsa03050	2.19324884
16	mRNA surveillance pathway_Homo sapiens_hsa03015	2.11999031
17	RNA degradation_Homo sapiens_hsa03018	2.03466159
18	Propanoate metabolism_Homo sapiens_hsa00640	2.02629094
19	Basal transcription factors_Homo sapiens_hsa03022	1.99566279
20	Pyrimidine metabolism_Homo sapiens_hsa00240	1.99077968
21	One carbon pool by folate_Homo sapiens_hsa00670	1.98543006
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.92707092
23	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.83728019
24	Fatty acid elongation_Homo sapiens_hsa00062	1.73850555
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.45183315
26	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.32882656
27	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.32808439
28	Purine metabolism_Homo sapiens_hsa00230	1.32570895
29	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.30930265
30	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.30929956
31	Oocyte meiosis_Homo sapiens_hsa04114	1.25188595
32	p53 signaling pathway_Homo sapiens_hsa04115	1.24737373
33	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.24650038
34	Lysine degradation_Homo sapiens_hsa00310	1.19527258
35	Butanoate metabolism_Homo sapiens_hsa00650	1.15796481
36	Primary immunodeficiency_Homo sapiens_hsa05340	1.13585665
37	Viral carcinogenesis_Homo sapiens_hsa05203	1.05359556
38	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.04027366
39	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.02660083
40	Colorectal cancer_Homo sapiens_hsa05210	0.98747332
41	Pyruvate metabolism_Homo sapiens_hsa00620	0.98576773
42	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.88046945
43	HTLV-I infection_Homo sapiens_hsa05166	0.86031902
44	Oxidative phosphorylation_Homo sapiens_hsa00190	0.85896819
45	Herpes simplex infection_Homo sapiens_hsa05168	0.85836762
46	Fatty acid metabolism_Homo sapiens_hsa01212	0.80843019
47	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.80641267
48	Alcoholism_Homo sapiens_hsa05034	0.79417278
49	Antigen processing and presentation_Homo sapiens_hsa04612	0.78659540
50	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.77158875
51	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.76431457
52	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.72747709
53	Measles_Homo sapiens_hsa05162	0.68606340
54	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.68231610
55	Parkinsons disease_Homo sapiens_hsa05012	0.66266025
56	Non-small cell lung cancer_Homo sapiens_hsa05223	0.64092872
57	MicroRNAs in cancer_Homo sapiens_hsa05206	0.64074920
58	Carbon metabolism_Homo sapiens_hsa01200	0.62652583
59	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.62230243
60	Steroid biosynthesis_Homo sapiens_hsa00100	0.61553346
61	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.60986473
62	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.60349190
63	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.59783394
64	Hepatitis B_Homo sapiens_hsa05161	0.59571547
65	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.59467407
66	Regulation of autophagy_Homo sapiens_hsa04140	0.58523693
67	Acute myeloid leukemia_Homo sapiens_hsa05221	0.55870272
68	Peroxisome_Homo sapiens_hsa04146	0.54561396
69	Small cell lung cancer_Homo sapiens_hsa05222	0.53715200
70	Thyroid cancer_Homo sapiens_hsa05216	0.53619542
71	Metabolic pathways_Homo sapiens_hsa01100	0.53293260
72	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.52575317
73	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.51642928
74	Prostate cancer_Homo sapiens_hsa05215	0.49832732
75	Endometrial cancer_Homo sapiens_hsa05213	0.49647924
76	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.48938011
77	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.46309382
78	Melanoma_Homo sapiens_hsa05218	0.46113822
79	Protein export_Homo sapiens_hsa03060	0.45349172
80	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.44967363
81	Pancreatic cancer_Homo sapiens_hsa05212	0.44075624
82	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.41199931
83	Adherens junction_Homo sapiens_hsa04520	0.40715093
84	Influenza A_Homo sapiens_hsa05164	0.40686153
85	Glutathione metabolism_Homo sapiens_hsa00480	0.40652950
86	Olfactory transduction_Homo sapiens_hsa04740	0.37038102
87	Alzheimers disease_Homo sapiens_hsa05010	0.35604875
88	Basal cell carcinoma_Homo sapiens_hsa05217	0.35419816
89	Phototransduction_Homo sapiens_hsa04744	0.35243741
90	Pathways in cancer_Homo sapiens_hsa05200	0.34862598
91	Huntingtons disease_Homo sapiens_hsa05016	0.33999130
92	Allograft rejection_Homo sapiens_hsa05330	0.33745168
93	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.33683299
94	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.33526705
95	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.33436218
96	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.33392320
97	mTOR signaling pathway_Homo sapiens_hsa04150	0.32014959
98	Apoptosis_Homo sapiens_hsa04210	0.31710417
99	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.31595716
100	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.31539107
101	Wnt signaling pathway_Homo sapiens_hsa04310	0.31273323
102	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.31052641
103	Glioma_Homo sapiens_hsa05214	0.30060991
104	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.29454660
105	Shigellosis_Homo sapiens_hsa05131	0.29242265
106	beta-Alanine metabolism_Homo sapiens_hsa00410	0.28968561
107	Type I diabetes mellitus_Homo sapiens_hsa04940	0.28748030
108	Sulfur metabolism_Homo sapiens_hsa00920	0.27758498
109	Nicotine addiction_Homo sapiens_hsa05033	0.27351736
110	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.26871146
111	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.26115669
112	Folate biosynthesis_Homo sapiens_hsa00790	0.26055415
113	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.26016748
114	Selenocompound metabolism_Homo sapiens_hsa00450	0.25761640
115	Arginine and proline metabolism_Homo sapiens_hsa00330	0.23789264
116	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.23714087
117	Hippo signaling pathway_Homo sapiens_hsa04390	0.22776825
118	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.22605512
119	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.22277275
120	FoxO signaling pathway_Homo sapiens_hsa04068	0.22000174
121	Legionellosis_Homo sapiens_hsa05134	0.21535992
122	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.21209589
123	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.20859197
124	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.20705151
125	Viral myocarditis_Homo sapiens_hsa05416	0.19890310
126	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.19863727
127	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.19761694
128	Long-term potentiation_Homo sapiens_hsa04720	0.19596786
129	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.19476651
130	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.19338143
131	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.19093940
132	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.18378428
133	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.18220022
134	Platelet activation_Homo sapiens_hsa04611	0.18044140
135	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.17503981
136	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.16651349
137	Notch signaling pathway_Homo sapiens_hsa04330	0.15814126
138	Glucagon signaling pathway_Homo sapiens_hsa04922	0.15667397
139	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.14799125
140	Fatty acid degradation_Homo sapiens_hsa00071	0.14776700
141	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.14654648
142	ABC transporters_Homo sapiens_hsa02010	0.13861164
143	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.13511030
144	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.13396586
145	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.13137962
146	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.12764622
147	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.11005054
148	Circadian rhythm_Homo sapiens_hsa04710	0.08077721

PMS2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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