PMS2CL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1somatic diversification of immune receptors via somatic mutation (GO:0002566)4.38917426
2somatic hypermutation of immunoglobulin genes (GO:0016446)4.38917426
3positive regulation of protein homooligomerization (GO:0032464)4.26230731
4negative regulation of cAMP-mediated signaling (GO:0043951)4.18481579
5synaptic vesicle maturation (GO:0016188)4.03079945
6monoubiquitinated protein deubiquitination (GO:0035520)3.99154044
7histone H3-K9 methylation (GO:0051567)3.90974332
8snRNA transcription (GO:0009301)3.89753596
9positive regulation of CREB transcription factor activity (GO:0032793)3.86946674
10nonmotile primary cilium assembly (GO:0035058)3.54542552
11heart valve formation (GO:0003188)3.51468373
12protein K11-linked deubiquitination (GO:0035871)3.48863448
13histone H3-K9 modification (GO:0061647)3.40117912
14histone H3-K4 trimethylation (GO:0080182)3.36882108
15regulation of histone H3-K27 methylation (GO:0061085)3.21019509
16establishment of mitochondrion localization (GO:0051654)3.12444085
17cardiovascular system development (GO:0072358)3.10705828
18peptidyl-lysine trimethylation (GO:0018023)3.10400941
19protein localization to synapse (GO:0035418)3.08391151
20peptidyl-lysine methylation (GO:0018022)3.07011615
21striatum development (GO:0021756)2.94591929
22head development (GO:0060322)2.94153966
23establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.93644053
24mitochondrion transport along microtubule (GO:0047497)2.93644053
25mitochondrial respiratory chain complex I assembly (GO:0032981)2.92260789
26NADH dehydrogenase complex assembly (GO:0010257)2.92260789
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.92260789
28negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.92110398
29regulation of telomere maintenance (GO:0032204)2.90898925
30neurotransmitter-gated ion channel clustering (GO:0072578)2.87765266
31phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.87651840
32respiratory chain complex IV assembly (GO:0008535)2.86808737
33cell migration in hindbrain (GO:0021535)2.83557122
34gamma-aminobutyric acid transport (GO:0015812)2.76733069
35establishment of protein localization to Golgi (GO:0072600)2.75860612
36response to pheromone (GO:0019236)2.75553002
37negative regulation of synaptic transmission, GABAergic (GO:0032229)2.75329227
38adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.74759979
39postsynaptic membrane organization (GO:0001941)2.73671855
40neurofilament cytoskeleton organization (GO:0060052)2.73533203
41protein localization to Golgi apparatus (GO:0034067)2.73306431
42regulation of DNA endoreduplication (GO:0032875)2.72063508
43cell wall macromolecule catabolic process (GO:0016998)2.70545967
44neuron cell-cell adhesion (GO:0007158)2.70468301
45histone lysine methylation (GO:0034968)2.69202185
46negative regulation of mRNA processing (GO:0050686)2.67863971
47microtubule anchoring (GO:0034453)2.67031458
48pyrimidine nucleobase catabolic process (GO:0006208)2.66604257
49seminiferous tubule development (GO:0072520)2.66457454
50brain morphogenesis (GO:0048854)2.65502218
51neural tube formation (GO:0001841)2.63681820
52histone H3-K4 methylation (GO:0051568)2.63150964
53detection of light stimulus involved in sensory perception (GO:0050962)2.61939105
54detection of light stimulus involved in visual perception (GO:0050908)2.61939105
55negative regulation of organelle assembly (GO:1902116)2.61688476
56regulation of chromatin binding (GO:0035561)2.61662625
57pyrimidine dimer repair (GO:0006290)2.57698484
58histone deubiquitination (GO:0016578)2.56984604
59DNA double-strand break processing (GO:0000729)2.56621309
60presynaptic membrane assembly (GO:0097105)2.55810282
61mRNA splice site selection (GO:0006376)2.53761651
62histone H3 deacetylation (GO:0070932)2.52970142
63microtubule depolymerization (GO:0007019)2.49622150
64regulation of nuclear cell cycle DNA replication (GO:0033262)2.49061497
65dendrite morphogenesis (GO:0048813)2.48768628
66establishment of melanosome localization (GO:0032401)2.48663865
67cytochrome complex assembly (GO:0017004)2.48456863
68negative regulation of translation, ncRNA-mediated (GO:0040033)2.47708159
69regulation of translation, ncRNA-mediated (GO:0045974)2.47708159
70negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.47708159
71synaptic vesicle endocytosis (GO:0048488)2.46869166
72sensory perception of smell (GO:0007608)2.46524599
73cytoplasmic mRNA processing body assembly (GO:0033962)2.45165677
74establishment of pigment granule localization (GO:0051905)2.44606583
75replication fork processing (GO:0031297)2.43611508
76positive regulation of dendritic spine morphogenesis (GO:0061003)2.43035656
77phosphatidylinositol phosphorylation (GO:0046854)2.42435012
78intra-Golgi vesicle-mediated transport (GO:0006891)2.42127705
79histone H4-K16 acetylation (GO:0043984)2.41983348
80mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.41928473
81positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.41928473
82presynaptic membrane organization (GO:0097090)2.41597209
83negative regulation of digestive system process (GO:0060457)2.38624086
84negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.37905680
85ncRNA catabolic process (GO:0034661)2.37270380
86intestinal cholesterol absorption (GO:0030299)2.37021697
87regulation of cAMP-mediated signaling (GO:0043949)2.36688659
88protein K48-linked ubiquitination (GO:0070936)2.34980608
89protein complex biogenesis (GO:0070271)2.34825661
90rRNA catabolic process (GO:0016075)2.34302607
91positive regulation of T cell apoptotic process (GO:0070234)2.33878929
92ubiquinone biosynthetic process (GO:0006744)2.33871302
93regulation of mRNA splicing, via spliceosome (GO:0048024)2.33417051
94negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.33091835
95microtubule nucleation (GO:0007020)2.32825997
96protein K48-linked deubiquitination (GO:0071108)2.32085269
97regulation of protein homooligomerization (GO:0032462)2.31379772
98resolution of meiotic recombination intermediates (GO:0000712)2.28551591
99melanosome localization (GO:0032400)2.28342223
100melanosome transport (GO:0032402)2.27036693

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_21737748_ChIP-Seq_TLL_Human4.17472502
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.57584092
3TP63_19390658_ChIP-ChIP_HaCaT_Human3.14473010
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.94400919
5ZNF274_21170338_ChIP-Seq_K562_Hela2.84426162
6TAF15_26573619_Chip-Seq_HEK293_Human2.58730847
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.42670692
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.41838377
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.36598475
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.33747644
11CIITA_25753668_ChIP-Seq_RAJI_Human2.25073232
12EZH2_22144423_ChIP-Seq_EOC_Human2.24712692
13PKCTHETA_26484144_Chip-Seq_BREAST_Human2.17234092
14IGF1R_20145208_ChIP-Seq_DFB_Human2.13938956
15GABP_19822575_ChIP-Seq_HepG2_Human2.11857465
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.05198422
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.03810437
18FUS_26573619_Chip-Seq_HEK293_Human2.03675022
19SALL1_21062744_ChIP-ChIP_HESCs_Human1.98847382
20FOXP3_21729870_ChIP-Seq_TREG_Human1.95949414
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.92168110
22VDR_23849224_ChIP-Seq_CD4+_Human1.91797865
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.83072289
24EWS_26573619_Chip-Seq_HEK293_Human1.77488430
25FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74802378
26KDM5A_27292631_Chip-Seq_BREAST_Human1.71096778
27IRF1_19129219_ChIP-ChIP_H3396_Human1.67497886
28REST_21632747_ChIP-Seq_MESCs_Mouse1.65872871
29VDR_22108803_ChIP-Seq_LS180_Human1.65409985
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.62891431
31GATA1_26923725_Chip-Seq_HPCs_Mouse1.62397854
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.61159708
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.56556063
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55738090
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.49304523
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47743461
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.47605117
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47328796
39KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.44214268
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40456120
41TP53_22573176_ChIP-Seq_HFKS_Human1.37871879
42CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.37667364
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37264006
44MYC_22102868_ChIP-Seq_BL_Human1.36503906
45ELK1_19687146_ChIP-ChIP_HELA_Human1.33225567
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31378106
47TP53_16413492_ChIP-PET_HCT116_Human1.30968622
48CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.30618266
49KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.29816484
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.29399173
51TTF2_22483619_ChIP-Seq_HELA_Human1.26929707
52AR_21572438_ChIP-Seq_LNCaP_Human1.25259744
53BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.25088554
54E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24283363
55ER_23166858_ChIP-Seq_MCF-7_Human1.23911945
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.23348445
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.23177038
58GBX2_23144817_ChIP-Seq_PC3_Human1.19546686
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.18484418
60CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17864966
61STAT3_23295773_ChIP-Seq_U87_Human1.16468478
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15875951
63SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15440011
64E2F1_17053090_ChIP-ChIP_MCF-7_Human1.15135352
65DCP1A_22483619_ChIP-Seq_HELA_Human1.14878333
66RARB_27405468_Chip-Seq_BRAIN_Mouse1.14295842
67CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.14217208
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.12220695
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.11473183
70CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.10907534
71RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10481875
72E2F1_21310950_ChIP-Seq_MCF-7_Human1.10015400
73RNF2_27304074_Chip-Seq_NSC_Mouse1.09784962
74FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.08676862
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08231380
76ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07318766
77MYC_18940864_ChIP-ChIP_HL60_Human1.06646613
78XRN2_22483619_ChIP-Seq_HELA_Human1.06361213
79SOX9_26525672_Chip-Seq_HEART_Mouse1.05577891
80PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03196719
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02516000
82CBP_20019798_ChIP-Seq_JUKART_Human1.02516000
83FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.00437763
84ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00222562
85MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99472387
86PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98383249
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97428948
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97098994
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96858141
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96354489
91REST_19997604_ChIP-ChIP_NEURONS_Mouse0.95430432
92POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94310337
93TCF4_23295773_ChIP-Seq_U87_Human0.92331066
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90908820
95SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90441944
96POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89456735
97MYC_18555785_ChIP-Seq_MESCs_Mouse0.87884542
98CTBP2_25329375_ChIP-Seq_LNCAP_Human0.86570246
99ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84578980
100ETV2_25802403_ChIP-Seq_MESCs_Mouse0.84027215

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting4.13556892
2MP0008877_abnormal_DNA_methylation3.29398729
3MP0003123_paternal_imprinting3.06102921
4MP0008057_abnormal_DNA_replication2.74947799
5MP0003121_genomic_imprinting2.64152491
6MP0000569_abnormal_digit_pigmentation2.63218628
7MP0002822_catalepsy2.50958966
8MP0005423_abnormal_somatic_nervous2.45721152
9MP0003122_maternal_imprinting2.41706097
10MP0005646_abnormal_pituitary_gland2.26108291
11MP0003880_abnormal_central_pattern2.17864367
12MP0009046_muscle_twitch2.13013732
13MP0005645_abnormal_hypothalamus_physiol2.00326302
14MP0004859_abnormal_synaptic_plasticity2.00083474
15MP0000778_abnormal_nervous_system1.85449906
16MP0001984_abnormal_olfaction1.84042199
17MP0005499_abnormal_olfactory_system1.81796265
18MP0005394_taste/olfaction_phenotype1.81796265
19MP0001529_abnormal_vocalization1.79195940
20MP0000631_abnormal_neuroendocrine_gland1.78251455
21MP0006035_abnormal_mitochondrial_morpho1.76840358
22MP0006292_abnormal_olfactory_placode1.74583114
23MP0003635_abnormal_synaptic_transmissio1.66834950
24MP0003693_abnormal_embryo_hatching1.61733026
25MP0002653_abnormal_ependyma_morphology1.56583425
26MP0002163_abnormal_gland_morphology1.53673405
27MP0010094_abnormal_chromosome_stability1.53504405
28MP0003656_abnormal_erythrocyte_physiolo1.53104941
29MP0008058_abnormal_DNA_repair1.46871755
30MP0000955_abnormal_spinal_cord1.46617863
31MP0002063_abnormal_learning/memory/cond1.43343845
32MP0001502_abnormal_circadian_rhythm1.42373534
33MP0005551_abnormal_eye_electrophysiolog1.35499046
34MP0002064_seizures1.35037404
35MP0004142_abnormal_muscle_tone1.33632696
36MP0005386_behavior/neurological_phenoty1.32925862
37MP0004924_abnormal_behavior1.32925862
38MP0006276_abnormal_autonomic_nervous1.32762392
39MP0008995_early_reproductive_senescence1.30836261
40MP0002557_abnormal_social/conspecific_i1.28083465
41MP0002572_abnormal_emotion/affect_behav1.27891339
42MP0001986_abnormal_taste_sensitivity1.27634103
43MP0001919_abnormal_reproductive_system1.26773636
44MP0000427_abnormal_hair_cycle1.24203172
45MP0008789_abnormal_olfactory_epithelium1.24148021
46MP0002272_abnormal_nervous_system1.22612603
47MP0002882_abnormal_neuron_morphology1.20256331
48MP0003111_abnormal_nucleus_morphology1.19440991
49MP0003786_premature_aging1.17322768
50MP0002184_abnormal_innervation1.17073733
51MP0003077_abnormal_cell_cycle1.16682008
52MP0005379_endocrine/exocrine_gland_phen1.15614727
53MP0001929_abnormal_gametogenesis1.15080195
54MP0003698_abnormal_male_reproductive1.12266167
55MP0002928_abnormal_bile_duct1.10650581
56MP0002210_abnormal_sex_determination1.09207035
57MP0009745_abnormal_behavioral_response1.07156537
58MP0002067_abnormal_sensory_capabilities1.05359067
59MP0004811_abnormal_neuron_physiology1.05116926
60MP0004381_abnormal_hair_follicle1.00320579
61MP0002152_abnormal_brain_morphology0.99713132
62MP0000015_abnormal_ear_pigmentation0.99259281
63MP0003221_abnormal_cardiomyocyte_apopto0.96322181
64MP0002752_abnormal_somatic_nervous0.95808590
65MP0002909_abnormal_adrenal_gland0.95206916
66MP0002229_neurodegeneration0.93628319
67MP0002095_abnormal_skin_pigmentation0.93216833
68MP0002638_abnormal_pupillary_reflex0.90852725
69MP0001145_abnormal_male_reproductive0.90671315
70MP0004742_abnormal_vestibular_system0.89824723
71MP0005187_abnormal_penis_morphology0.88412965
72MP0001501_abnormal_sleep_pattern0.88027293
73MP0002160_abnormal_reproductive_system0.86788295
74MP0003861_abnormal_nervous_system0.86664445
75MP0004043_abnormal_pH_regulation0.85187278
76MP0000358_abnormal_cell_content/0.84748363
77MP0001968_abnormal_touch/_nociception0.83415994
78MP0000653_abnormal_sex_gland0.81824769
79MP0003890_abnormal_embryonic-extraembry0.81716540
80MP0003633_abnormal_nervous_system0.79598179
81MP0001486_abnormal_startle_reflex0.79595337
82MP0003011_delayed_dark_adaptation0.79525317
83MP0002066_abnormal_motor_capabilities/c0.78484961
84MP0001188_hyperpigmentation0.77872032
85MP0005389_reproductive_system_phenotype0.76754953
86MP0005174_abnormal_tail_pigmentation0.75654060
87MP0004885_abnormal_endolymph0.73296382
88MP0000647_abnormal_sebaceous_gland0.71417786
89MP0005195_abnormal_posterior_eye0.69140451
90MP0003879_abnormal_hair_cell0.68821871
91MP0005075_abnormal_melanosome_morpholog0.68630386
92MP0001764_abnormal_homeostasis0.67878719
93MP0003315_abnormal_perineum_morphology0.67836838
94MP0003646_muscle_fatigue0.65202125
95MP0000372_irregular_coat_pigmentation0.63851506
96MP0003631_nervous_system_phenotype0.62644851
97MP0002938_white_spotting0.60725500
98MP0008007_abnormal_cellular_replicative0.60254635
99MP0002161_abnormal_fertility/fecundity0.58790422
100MP0002736_abnormal_nociception_after0.58759555

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of alanine metabolism (HP:0010916)5.02734836
2Hyperalaninemia (HP:0003348)5.02734836
3Abnormality of pyruvate family amino acid metabolism (HP:0010915)5.02734836
4Chronic hepatic failure (HP:0100626)3.55955500
5Abnormality of DNA repair (HP:0003254)3.40701606
6Gait imbalance (HP:0002141)3.27276395
7Nephrogenic diabetes insipidus (HP:0009806)3.16355151
8Medial flaring of the eyebrow (HP:0010747)3.10560343
9Absent speech (HP:0001344)3.06166263
10Poor coordination (HP:0002370)3.04292411
11Congenital primary aphakia (HP:0007707)2.99746146
12Epileptic encephalopathy (HP:0200134)2.98153247
13Genetic anticipation (HP:0003743)2.79240218
14Type II lissencephaly (HP:0007260)2.76445899
15Retinal dysplasia (HP:0007973)2.74811137
16Cerebellar dysplasia (HP:0007033)2.71539017
17Progressive cerebellar ataxia (HP:0002073)2.58619054
18Drooling (HP:0002307)2.56875676
19Basal cell carcinoma (HP:0002671)2.51847836
20Pancreatic fibrosis (HP:0100732)2.48096491
21Excessive salivation (HP:0003781)2.44174067
22Abnormality of midbrain morphology (HP:0002418)2.41041583
23Molar tooth sign on MRI (HP:0002419)2.41041583
24Reticulocytopenia (HP:0001896)2.40049784
25Chromsome breakage (HP:0040012)2.33044603
26Protruding tongue (HP:0010808)2.32733834
27Abnormality of cells of the erythroid lineage (HP:0012130)2.32000987
28Hyperthyroidism (HP:0000836)2.28571322
29Nephronophthisis (HP:0000090)2.27503880
30Vaginal atresia (HP:0000148)2.23714457
31Hyperventilation (HP:0002883)2.21963701
32Abnormal hair whorl (HP:0010721)2.21903027
33Short foot (HP:0001773)2.19204875
34Pancreatic cysts (HP:0001737)2.15985438
35Genital tract atresia (HP:0001827)2.15603874
36Lissencephaly (HP:0001339)2.14243300
37Progressive microcephaly (HP:0000253)2.14212817
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.10174974
39Squamous cell carcinoma (HP:0002860)2.09599519
40Failure to thrive in infancy (HP:0001531)2.03217199
41Broad-based gait (HP:0002136)2.02288180
42Birth length less than 3rd percentile (HP:0003561)2.01446571
43Truncal obesity (HP:0001956)1.98785000
44Status epilepticus (HP:0002133)1.97215312
45Myokymia (HP:0002411)1.96983804
46Overlapping toe (HP:0001845)1.94247057
47Febrile seizures (HP:0002373)1.94171836
48Hip dysplasia (HP:0001385)1.93491362
49Abnormality of the renal medulla (HP:0100957)1.91901646
50Fair hair (HP:0002286)1.91874979
51Bony spicule pigmentary retinopathy (HP:0007737)1.87486048
52Clumsiness (HP:0002312)1.87223893
53Polyphagia (HP:0002591)1.86838407
54Poikiloderma (HP:0001029)1.85339183
55Gastroesophageal reflux (HP:0002020)1.84454184
56Delayed myelination (HP:0012448)1.82695056
57Hypoplastic iliac wings (HP:0002866)1.81298069
58Specific learning disability (HP:0001328)1.80867598
59Gaze-evoked nystagmus (HP:0000640)1.77580931
60Short chin (HP:0000331)1.77362062
61Cutaneous melanoma (HP:0012056)1.76747447
62Aplasia/Hypoplasia of the uvula (HP:0010293)1.75976929
63Abnormality of reticulocytes (HP:0004312)1.73396718
64Stenosis of the external auditory canal (HP:0000402)1.72916023
6511 pairs of ribs (HP:0000878)1.72250988
66Hypoplasia of the corpus callosum (HP:0002079)1.71955305
67Astigmatism (HP:0000483)1.71654994
68Pachygyria (HP:0001302)1.70759871
69Volvulus (HP:0002580)1.70618803
70Intellectual disability, severe (HP:0010864)1.70187651
71Sensory axonal neuropathy (HP:0003390)1.69741951
72Ependymoma (HP:0002888)1.69405897
73Absent thumb (HP:0009777)1.68288708
74Increased serum lactate (HP:0002151)1.68133851
75Obsessive-compulsive behavior (HP:0000722)1.68023121
76Abnormal number of erythroid precursors (HP:0012131)1.67687229
77Dyskinesia (HP:0100660)1.67434692
78Aplasia/Hypoplasia of the brainstem (HP:0007362)1.66328932
79Hypoplasia of the brainstem (HP:0002365)1.66328932
80True hermaphroditism (HP:0010459)1.65940155
81Atonic seizures (HP:0010819)1.65782478
82Abnormality of chromosome stability (HP:0003220)1.65500311
83Ankle clonus (HP:0011448)1.65058554
84Thick eyebrow (HP:0000574)1.63653714
85Abnormality of the renal cortex (HP:0011035)1.61894332
86High anterior hairline (HP:0009890)1.61841090
87Absence seizures (HP:0002121)1.61419249
88Agitation (HP:0000713)1.61126797
89Asthma (HP:0002099)1.61091161
90Prominent nasal bridge (HP:0000426)1.59240097
91Renal tubular acidosis (HP:0001947)1.58950910
92Chorioretinal coloboma (HP:0000567)1.58789205
93Ectopic kidney (HP:0000086)1.58443340
94Attenuation of retinal blood vessels (HP:0007843)1.57701673
95Abnormality of the sella turcica (HP:0002679)1.56193883
96Atresia of the external auditory canal (HP:0000413)1.55465777
97Sloping forehead (HP:0000340)1.53046697
98Astrocytoma (HP:0009592)1.52712618
99Abnormality of the astrocytes (HP:0100707)1.52712618
100Abnormality of the labia minora (HP:0012880)1.52606604

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.71270178
2SIK22.61952253
3BRD42.58889010
4FRK2.53531212
5TAOK32.51190987
6MAPK132.18520262
7MAP3K42.15710861
8PRKD31.95732594
9CAMKK21.94146110
10MARK11.93326321
11MINK11.89763520
12CAMK1D1.73964234
13DYRK31.71500709
14MAP4K11.62342726
15NTRK21.52945899
16WNK41.49757420
17MAP4K21.49163751
18ZAK1.46035651
19PIK3CA1.42495873
20AKT31.32497203
21ICK1.31417321
22MKNK21.31410367
23PRKCH1.24412271
24DYRK21.23578148
25CSNK1A1L1.22663948
26NUAK11.21788879
27CAMK1G1.20532204
28ATR1.19856852
29EPHA41.19152265
30MAP3K111.18822155
31CCNB11.17372979
32CAMKK11.17330027
33CSNK1G21.16821381
34PIM21.15685628
35SGK31.11262882
36MAP3K91.11158057
37MAP2K41.09615351
38STK391.09171331
39SGK4941.07775527
40SGK2231.07775527
41PAK31.06690633
42STK111.06683743
43INSRR1.04393932
44PRKCG1.03696356
45SGK21.01139632
46CSNK1G30.98224114
47CHUK0.96288065
48TAF10.96191763
49CDK120.95761678
50TNK20.92743307
51PRKAA10.86793993
52MAP3K130.85792693
53RAF10.85158202
54TNIK0.83692558
55IKBKB0.82158444
56SGK10.79549712
57PRKCZ0.76984212
58CDK30.75307683
59DYRK1A0.74989391
60STK160.74868145
61CSNK1G10.74814788
62TYRO30.72974189
63BRSK20.72038632
64ATM0.72006061
65NEK20.70223236
66CDC70.70108174
67PKN20.69992448
68PDK20.69888621
69GSK3B0.69361338
70MAPK80.66731698
71MAP2K70.66385694
72FGFR20.66350407
73CSNK1D0.66217010
74MAPK110.65644165
75CAMK40.62454093
76CDK20.61177435
77CDK50.57215949
78PRKCQ0.57120169
79MAP3K60.56935298
80WNK10.55914594
81CHEK10.55167967
82CDK10.54941700
83BLK0.54128167
84MAPK100.53682041
85MTOR0.53211199
86MARK30.53095830
87KSR10.51961778
88CAMK10.50364357
89STK38L0.49788553
90RIPK40.49509120
91MAP3K50.47336297
92MAP2K60.46595985
93OXSR10.46589113
94RPS6KA50.46059592
95AKT20.45849873
96CSNK1E0.45842763
97PTK60.43194858
98MAPK140.42817863
99STK380.41471191
100RPS6KA30.39022722

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034602.94898028
2Basal transcription factors_Homo sapiens_hsa030222.68061034
3Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.54993902
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.53671385
5RNA polymerase_Homo sapiens_hsa030202.23447020
6Nicotine addiction_Homo sapiens_hsa050332.18724305
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.17478377
8Phototransduction_Homo sapiens_hsa047442.04994283
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.02487768
10Morphine addiction_Homo sapiens_hsa050321.66274402
11Homologous recombination_Homo sapiens_hsa034401.65833073
12Dorso-ventral axis formation_Homo sapiens_hsa043201.57856498
13Butanoate metabolism_Homo sapiens_hsa006501.55292641
14Sulfur relay system_Homo sapiens_hsa041221.53336197
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51597258
16mRNA surveillance pathway_Homo sapiens_hsa030151.50933522
17ABC transporters_Homo sapiens_hsa020101.43234108
18Phosphatidylinositol signaling system_Homo sapiens_hsa040701.42095399
19Spliceosome_Homo sapiens_hsa030401.41694407
20Synaptic vesicle cycle_Homo sapiens_hsa047211.40260280
21Lysine degradation_Homo sapiens_hsa003101.33996635
22Notch signaling pathway_Homo sapiens_hsa043301.31102025
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.28988715
24RNA degradation_Homo sapiens_hsa030181.27786327
25Alcoholism_Homo sapiens_hsa050341.23119028
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22986319
27FoxO signaling pathway_Homo sapiens_hsa040681.21124739
28GABAergic synapse_Homo sapiens_hsa047271.20939491
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20006074
30Choline metabolism in cancer_Homo sapiens_hsa052311.19007105
31Circadian rhythm_Homo sapiens_hsa047101.18874989
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.17997296
33ErbB signaling pathway_Homo sapiens_hsa040121.14454733
34Chronic myeloid leukemia_Homo sapiens_hsa052201.13619189
35p53 signaling pathway_Homo sapiens_hsa041151.13192617
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.11609572
37B cell receptor signaling pathway_Homo sapiens_hsa046621.11389110
38Glutamatergic synapse_Homo sapiens_hsa047241.10805740
39Regulation of autophagy_Homo sapiens_hsa041401.09120794
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08834502
41mTOR signaling pathway_Homo sapiens_hsa041501.08151439
42Ribosome_Homo sapiens_hsa030101.06512144
43T cell receptor signaling pathway_Homo sapiens_hsa046601.02915731
44Inositol phosphate metabolism_Homo sapiens_hsa005621.02728671
45Non-small cell lung cancer_Homo sapiens_hsa052231.01977765
46Axon guidance_Homo sapiens_hsa043600.99607945
47Dopaminergic synapse_Homo sapiens_hsa047280.98499285
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.98183635
49Endometrial cancer_Homo sapiens_hsa052130.96802962
50Collecting duct acid secretion_Homo sapiens_hsa049660.94126789
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92466943
52Selenocompound metabolism_Homo sapiens_hsa004500.92391075
53RNA transport_Homo sapiens_hsa030130.92263600
54Fatty acid biosynthesis_Homo sapiens_hsa000610.86388891
55Cocaine addiction_Homo sapiens_hsa050300.84550202
56Cholinergic synapse_Homo sapiens_hsa047250.82001890
57Olfactory transduction_Homo sapiens_hsa047400.81301485
58Pyrimidine metabolism_Homo sapiens_hsa002400.79621063
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79132823
60Renal cell carcinoma_Homo sapiens_hsa052110.78684281
61Mismatch repair_Homo sapiens_hsa034300.77828820
62Cell cycle_Homo sapiens_hsa041100.77668784
63Glioma_Homo sapiens_hsa052140.76278050
64Nucleotide excision repair_Homo sapiens_hsa034200.76162404
65Melanoma_Homo sapiens_hsa052180.75844676
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75691757
67Colorectal cancer_Homo sapiens_hsa052100.75488602
68VEGF signaling pathway_Homo sapiens_hsa043700.73129182
69Prolactin signaling pathway_Homo sapiens_hsa049170.73079499
70Type II diabetes mellitus_Homo sapiens_hsa049300.70876631
71Primary immunodeficiency_Homo sapiens_hsa053400.69793221
72NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69159049
73Long-term depression_Homo sapiens_hsa047300.68898626
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68592711
75Acute myeloid leukemia_Homo sapiens_hsa052210.68312213
76Prostate cancer_Homo sapiens_hsa052150.67073998
77Base excision repair_Homo sapiens_hsa034100.66838335
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65949061
79Epstein-Barr virus infection_Homo sapiens_hsa051690.64917415
80Viral carcinogenesis_Homo sapiens_hsa052030.62718206
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61849481
82MAPK signaling pathway_Homo sapiens_hsa040100.61081964
83Serotonergic synapse_Homo sapiens_hsa047260.59289002
84Hedgehog signaling pathway_Homo sapiens_hsa043400.57884394
85Circadian entrainment_Homo sapiens_hsa047130.57547220
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56504860
87Insulin secretion_Homo sapiens_hsa049110.55878756
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.55227649
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50355747
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.50293488
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50216511
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50203413
93Pancreatic cancer_Homo sapiens_hsa052120.48935178
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47945898
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46784368
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46114993
97Ether lipid metabolism_Homo sapiens_hsa005650.45741041
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45429770
99Vibrio cholerae infection_Homo sapiens_hsa051100.45351253
100Wnt signaling pathway_Homo sapiens_hsa043100.45135731

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »