

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 6.98365681 |
| 2 | ATP synthesis coupled proton transport (GO:0015986) | 6.05700468 |
| 3 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 6.05700468 |
| 4 | protein complex biogenesis (GO:0070271) | 5.01636505 |
| 5 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.93656750 |
| 6 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.87955382 |
| 7 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.87955382 |
| 8 | NADH dehydrogenase complex assembly (GO:0010257) | 4.87955382 |
| 9 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.87741185 |
| 10 | respiratory electron transport chain (GO:0022904) | 4.78546201 |
| 11 | chaperone-mediated protein transport (GO:0072321) | 4.70323475 |
| 12 | electron transport chain (GO:0022900) | 4.69601695 |
| 13 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.68679899 |
| 14 | proteasome assembly (GO:0043248) | 4.43968274 |
| 15 | ribosomal small subunit assembly (GO:0000028) | 4.41311515 |
| 16 | viral transcription (GO:0019083) | 4.07720970 |
| 17 | translational termination (GO:0006415) | 4.04312606 |
| 18 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.99507934 |
| 19 | rRNA modification (GO:0000154) | 3.98912798 |
| 20 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.97459186 |
| 21 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.91542512 |
| 22 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.88229550 |
| 23 | termination of RNA polymerase III transcription (GO:0006386) | 3.88229550 |
| 24 | cotranslational protein targeting to membrane (GO:0006613) | 3.87529687 |
| 25 | maturation of SSU-rRNA (GO:0030490) | 3.85912114 |
| 26 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.83218417 |
| 27 | protein targeting to ER (GO:0045047) | 3.80408492 |
| 28 | ribosomal large subunit biogenesis (GO:0042273) | 3.76860075 |
| 29 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.75510752 |
| 30 | sequestering of actin monomers (GO:0042989) | 3.69937155 |
| 31 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.69254187 |
| 32 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.69254187 |
| 33 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.66521725 |
| 34 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.62395648 |
| 35 | inner mitochondrial membrane organization (GO:0007007) | 3.60843118 |
| 36 | protein localization to endoplasmic reticulum (GO:0070972) | 3.59999373 |
| 37 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.59381867 |
| 38 | DNA ligation (GO:0006266) | 3.56231631 |
| 39 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.54299751 |
| 40 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.54299751 |
| 41 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.54299751 |
| 42 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.53354812 |
| 43 | negative regulation of ligase activity (GO:0051352) | 3.52448552 |
| 44 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.52448552 |
| 45 | pseudouridine synthesis (GO:0001522) | 3.49626570 |
| 46 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.49413299 |
| 47 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.49413299 |
| 48 | translational elongation (GO:0006414) | 3.48507596 |
| 49 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.48339092 |
| 50 | respiratory chain complex IV assembly (GO:0008535) | 3.47727245 |
| 51 | * mismatch repair (GO:0006298) | 3.47009666 |
| 52 | regulation of mitochondrial translation (GO:0070129) | 3.44207815 |
| 53 | oxidative phosphorylation (GO:0006119) | 3.42111859 |
| 54 | cytochrome complex assembly (GO:0017004) | 3.40482047 |
| 55 | DNA deamination (GO:0045006) | 3.38893809 |
| 56 | protein neddylation (GO:0045116) | 3.38150879 |
| 57 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.36905430 |
| 58 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.36905430 |
| 59 | ATP biosynthetic process (GO:0006754) | 3.36645734 |
| 60 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.35458754 |
| 61 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.31066030 |
| 62 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.28675260 |
| 63 | hydrogen ion transmembrane transport (GO:1902600) | 3.26878117 |
| 64 | mannosylation (GO:0097502) | 3.26834048 |
| 65 | cullin deneddylation (GO:0010388) | 3.25720101 |
| 66 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.24376110 |
| 67 | rRNA methylation (GO:0031167) | 3.21833306 |
| 68 | translation (GO:0006412) | 3.21749374 |
| 69 | platelet dense granule organization (GO:0060155) | 3.18052736 |
| 70 | establishment of integrated proviral latency (GO:0075713) | 3.18043865 |
| 71 | translational initiation (GO:0006413) | 3.17359844 |
| 72 | spliceosomal snRNP assembly (GO:0000387) | 3.14071566 |
| 73 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.13316298 |
| 74 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.13316298 |
| 75 | protein deneddylation (GO:0000338) | 3.12825673 |
| 76 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 3.12382090 |
| 77 | cellular protein complex disassembly (GO:0043624) | 3.11988003 |
| 78 | centriole replication (GO:0007099) | 3.11072598 |
| 79 | positive regulation of ligase activity (GO:0051351) | 3.08811392 |
| 80 | purine deoxyribonucleoside triphosphate metabolic process (GO:0009215) | 3.08605168 |
| 81 | viral life cycle (GO:0019058) | 3.08027204 |
| 82 | peptidyl-histidine modification (GO:0018202) | 3.07573502 |
| 83 | CENP-A containing nucleosome assembly (GO:0034080) | 3.05810349 |
| 84 | protein-cofactor linkage (GO:0018065) | 3.05427816 |
| 85 | protein targeting to mitochondrion (GO:0006626) | 3.04284494 |
| 86 | chromatin remodeling at centromere (GO:0031055) | 3.04111138 |
| 87 | GTP biosynthetic process (GO:0006183) | 3.03435424 |
| 88 | proton transport (GO:0015992) | 3.02860671 |
| 89 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.01481224 |
| 90 | replication fork processing (GO:0031297) | 2.99054285 |
| 91 | hydrogen transport (GO:0006818) | 2.98734832 |
| 92 | establishment of protein localization to mitochondrion (GO:0072655) | 2.93475708 |
| 93 | base-excision repair, AP site formation (GO:0006285) | 2.93458203 |
| 94 | cellular component biogenesis (GO:0044085) | 2.88052351 |
| 95 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.87855549 |
| 96 | protein localization to mitochondrion (GO:0070585) | 2.85734588 |
| 97 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 2.85358251 |
| 98 | spliceosomal complex assembly (GO:0000245) | 2.84496683 |
| 99 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.84373907 |
| 100 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 2.82654343 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.08767769 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.62401311 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.59487483 |
| 4 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.48137268 |
| 5 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 3.41855890 |
| 6 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.38739827 |
| 7 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.28542516 |
| 8 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.21640856 |
| 9 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.16401260 |
| 10 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.15588550 |
| 11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.07614342 |
| 12 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.96466489 |
| 13 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.93207690 |
| 14 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.88937523 |
| 15 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.87994899 |
| 16 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.84884917 |
| 17 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.82760637 |
| 18 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.59168401 |
| 19 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.52899646 |
| 20 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.39788908 |
| 21 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.36998751 |
| 22 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.16383514 |
| 23 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.11477811 |
| 24 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.04940485 |
| 25 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.04917091 |
| 26 | VDR_22108803_ChIP-Seq_LS180_Human | 1.94957984 |
| 27 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.93243497 |
| 28 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.89893163 |
| 29 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.86687601 |
| 30 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.83747848 |
| 31 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.80839224 |
| 32 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.80633786 |
| 33 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.77064793 |
| 34 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.76295339 |
| 35 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.74889849 |
| 36 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.70132048 |
| 37 | EWS_26573619_Chip-Seq_HEK293_Human | 1.68489043 |
| 38 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.68346939 |
| 39 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.65832042 |
| 40 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.60321430 |
| 41 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.56999561 |
| 42 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.56679279 |
| 43 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.56194002 |
| 44 | FUS_26573619_Chip-Seq_HEK293_Human | 1.54141010 |
| 45 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.51613380 |
| 46 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.47463914 |
| 47 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.41413697 |
| 48 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.36715815 |
| 49 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.34257046 |
| 50 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.30051724 |
| 51 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.29457611 |
| 52 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.29306380 |
| 53 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.28387348 |
| 54 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.21554880 |
| 55 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.16133639 |
| 56 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.15422685 |
| 57 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.15288895 |
| 58 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.14505807 |
| 59 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.12257492 |
| 60 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.11247987 |
| 61 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.10804063 |
| 62 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.10123180 |
| 63 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.09607209 |
| 64 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.09393385 |
| 65 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.08792814 |
| 66 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.05462407 |
| 67 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.05362130 |
| 68 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.04253984 |
| 69 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.03723312 |
| 70 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.03192625 |
| 71 | P300_19829295_ChIP-Seq_ESCs_Human | 1.00717057 |
| 72 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.00679648 |
| 73 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.98964271 |
| 74 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.98964271 |
| 75 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.98319637 |
| 76 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 0.97325291 |
| 77 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.95663911 |
| 78 | AR_20517297_ChIP-Seq_VCAP_Human | 0.94442634 |
| 79 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.94074763 |
| 80 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.93960955 |
| 81 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.93809252 |
| 82 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.93788535 |
| 83 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.93412079 |
| 84 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.92932765 |
| 85 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.92690768 |
| 86 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.92506907 |
| 87 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.90114905 |
| 88 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.88359236 |
| 89 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.88320398 |
| 90 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.87437622 |
| 91 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.87075043 |
| 92 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.85002568 |
| 93 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.84247036 |
| 94 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.83656776 |
| 95 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.83656776 |
| 96 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.83039420 |
| 97 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.82751572 |
| 98 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.81383377 |
| 99 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.80679133 |
| 100 | NCOR_22424771_ChIP-Seq_293T_Human | 0.79558372 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008058_abnormal_DNA_repair | 3.70484601 |
| 2 | MP0009379_abnormal_foot_pigmentation | 2.85025241 |
| 3 | MP0006072_abnormal_retinal_apoptosis | 2.57994059 |
| 4 | MP0005084_abnormal_gallbladder_morpholo | 2.55209554 |
| 5 | MP0000372_irregular_coat_pigmentation | 2.54346312 |
| 6 | MP0010094_abnormal_chromosome_stability | 2.50260964 |
| 7 | MP0002102_abnormal_ear_morphology | 2.45637653 |
| 8 | MP0008877_abnormal_DNA_methylation | 2.44871373 |
| 9 | MP0001529_abnormal_vocalization | 2.43717912 |
| 10 | MP0006292_abnormal_olfactory_placode | 2.35340792 |
| 11 | MP0003011_delayed_dark_adaptation | 2.32456883 |
| 12 | MP0003693_abnormal_embryo_hatching | 2.31142880 |
| 13 | MP0003186_abnormal_redox_activity | 2.27765485 |
| 14 | MP0006036_abnormal_mitochondrial_physio | 2.17960655 |
| 15 | MP0003718_maternal_effect | 2.17166650 |
| 16 | MP0008995_early_reproductive_senescence | 2.17152820 |
| 17 | MP0003786_premature_aging | 2.16472618 |
| 18 | MP0009697_abnormal_copulation | 2.10229685 |
| 19 | MP0003806_abnormal_nucleotide_metabolis | 2.00978994 |
| 20 | MP0006035_abnormal_mitochondrial_morpho | 1.98505682 |
| 21 | MP0002938_white_spotting | 1.97352311 |
| 22 | MP0004957_abnormal_blastocyst_morpholog | 1.78682045 |
| 23 | MP0005645_abnormal_hypothalamus_physiol | 1.78662599 |
| 24 | MP0005075_abnormal_melanosome_morpholog | 1.72325330 |
| 25 | MP0000569_abnormal_digit_pigmentation | 1.72264383 |
| 26 | MP0004147_increased_porphyrin_level | 1.71460789 |
| 27 | MP0002736_abnormal_nociception_after | 1.71178371 |
| 28 | MP0005253_abnormal_eye_physiology | 1.67657590 |
| 29 | MP0003111_abnormal_nucleus_morphology | 1.63103582 |
| 30 | MP0003195_calcinosis | 1.57889158 |
| 31 | MP0005551_abnormal_eye_electrophysiolog | 1.57485752 |
| 32 | MP0004142_abnormal_muscle_tone | 1.55881145 |
| 33 | MP0008875_abnormal_xenobiotic_pharmacok | 1.55234903 |
| 34 | MP0003880_abnormal_central_pattern | 1.52349856 |
| 35 | MP0001764_abnormal_homeostasis | 1.51652149 |
| 36 | MP0002234_abnormal_pharynx_morphology | 1.45374133 |
| 37 | MP0008789_abnormal_olfactory_epithelium | 1.42899636 |
| 38 | MP0003136_yellow_coat_color | 1.39643163 |
| 39 | MP0003077_abnormal_cell_cycle | 1.38210638 |
| 40 | MP0001905_abnormal_dopamine_level | 1.36838971 |
| 41 | MP0008872_abnormal_physiological_respon | 1.35414057 |
| 42 | MP0008007_abnormal_cellular_replicative | 1.33813184 |
| 43 | MP0002837_dystrophic_cardiac_calcinosis | 1.31874545 |
| 44 | MP0001986_abnormal_taste_sensitivity | 1.31042565 |
| 45 | MP0001968_abnormal_touch/_nociception | 1.29761663 |
| 46 | MP0001293_anophthalmia | 1.27692894 |
| 47 | MP0002638_abnormal_pupillary_reflex | 1.27332444 |
| 48 | MP0001984_abnormal_olfaction | 1.26328360 |
| 49 | MP0008932_abnormal_embryonic_tissue | 1.25340391 |
| 50 | MP0001835_abnormal_antigen_presentation | 1.13338162 |
| 51 | MP0001929_abnormal_gametogenesis | 1.10863534 |
| 52 | MP0005646_abnormal_pituitary_gland | 1.08044930 |
| 53 | MP0005671_abnormal_response_to | 1.06519561 |
| 54 | MP0002277_abnormal_respiratory_mucosa | 1.04117244 |
| 55 | MP0004145_abnormal_muscle_electrophysio | 1.03885557 |
| 56 | MP0003121_genomic_imprinting | 1.02114944 |
| 57 | MP0006276_abnormal_autonomic_nervous | 1.00291970 |
| 58 | MP0002095_abnormal_skin_pigmentation | 1.00048229 |
| 59 | MP0005410_abnormal_fertilization | 0.97433336 |
| 60 | MP0002210_abnormal_sex_determination | 0.97313408 |
| 61 | MP0010386_abnormal_urinary_bladder | 0.95930162 |
| 62 | MP0002751_abnormal_autonomic_nervous | 0.95691897 |
| 63 | MP0000653_abnormal_sex_gland | 0.95182129 |
| 64 | MP0008057_abnormal_DNA_replication | 0.95142535 |
| 65 | MP0000631_abnormal_neuroendocrine_gland | 0.93040737 |
| 66 | MP0002132_abnormal_respiratory_system | 0.92988705 |
| 67 | MP0005408_hypopigmentation | 0.92957675 |
| 68 | MP0005394_taste/olfaction_phenotype | 0.91709712 |
| 69 | MP0005499_abnormal_olfactory_system | 0.91709712 |
| 70 | MP0001145_abnormal_male_reproductive | 0.91190423 |
| 71 | MP0002163_abnormal_gland_morphology | 0.90994149 |
| 72 | MP0004133_heterotaxia | 0.86746276 |
| 73 | MP0005379_endocrine/exocrine_gland_phen | 0.86727653 |
| 74 | MP0002735_abnormal_chemical_nociception | 0.85057579 |
| 75 | MP0002928_abnormal_bile_duct | 0.83405001 |
| 76 | MP0002282_abnormal_trachea_morphology | 0.82423673 |
| 77 | MP0003698_abnormal_male_reproductive | 0.81176346 |
| 78 | MP0000358_abnormal_cell_content/ | 0.80252783 |
| 79 | MP0001119_abnormal_female_reproductive | 0.78011851 |
| 80 | MP0005391_vision/eye_phenotype | 0.75829429 |
| 81 | MP0005085_abnormal_gallbladder_physiolo | 0.75342662 |
| 82 | MP0005083_abnormal_biliary_tract | 0.74878828 |
| 83 | MP0005332_abnormal_amino_acid | 0.73388017 |
| 84 | MP0009046_muscle_twitch | 0.73325569 |
| 85 | MP0002019_abnormal_tumor_incidence | 0.72763311 |
| 86 | MP0005389_reproductive_system_phenotype | 0.72497282 |
| 87 | MP0002822_catalepsy | 0.72018620 |
| 88 | MP0002653_abnormal_ependyma_morphology | 0.70182592 |
| 89 | MP0005266_abnormal_metabolism | 0.69634147 |
| 90 | MP0003787_abnormal_imprinting | 0.68980295 |
| 91 | MP0000689_abnormal_spleen_morphology | 0.66862948 |
| 92 | MP0001346_abnormal_lacrimal_gland | 0.65579313 |
| 93 | MP0005195_abnormal_posterior_eye | 0.65086080 |
| 94 | MP0005636_abnormal_mineral_homeostasis | 0.64009343 |
| 95 | MP0002160_abnormal_reproductive_system | 0.63371288 |
| 96 | MP0000516_abnormal_urinary_system | 0.62688388 |
| 97 | MP0005367_renal/urinary_system_phenotyp | 0.62688388 |
| 98 | MP0009745_abnormal_behavioral_response | 0.62510930 |
| 99 | MP0002272_abnormal_nervous_system | 0.61940850 |
| 100 | MP0009333_abnormal_splenocyte_physiolog | 0.61878396 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 5.32975529 |
| 2 | Mitochondrial inheritance (HP:0001427) | 5.00936168 |
| 3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.91668610 |
| 4 | Hepatocellular necrosis (HP:0001404) | 4.77290800 |
| 5 | Acute encephalopathy (HP:0006846) | 4.63762204 |
| 6 | Progressive macrocephaly (HP:0004481) | 4.55777529 |
| 7 | Increased hepatocellular lipid droplets (HP:0006565) | 4.50105608 |
| 8 | Increased CSF lactate (HP:0002490) | 4.44001896 |
| 9 | Hepatic necrosis (HP:0002605) | 4.38811436 |
| 10 | 3-Methylglutaconic aciduria (HP:0003535) | 4.23998807 |
| 11 | Lipid accumulation in hepatocytes (HP:0006561) | 4.11499070 |
| 12 | Renal Fanconi syndrome (HP:0001994) | 3.84832769 |
| 13 | Abnormal number of erythroid precursors (HP:0012131) | 3.78341135 |
| 14 | Cerebral edema (HP:0002181) | 3.60962631 |
| 15 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.45031722 |
| 16 | Increased intramyocellular lipid droplets (HP:0012240) | 3.28881246 |
| 17 | Reticulocytopenia (HP:0001896) | 3.19571303 |
| 18 | Type I transferrin isoform profile (HP:0003642) | 3.05267665 |
| 19 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.03295912 |
| 20 | Increased serum lactate (HP:0002151) | 3.02296258 |
| 21 | Pancreatic cysts (HP:0001737) | 2.96818745 |
| 22 | Exertional dyspnea (HP:0002875) | 2.93163241 |
| 23 | Lactic acidosis (HP:0003128) | 2.88701727 |
| 24 | Aplastic anemia (HP:0001915) | 2.83727968 |
| 25 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.82938430 |
| 26 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.82938430 |
| 27 | Congenital, generalized hypertrichosis (HP:0004540) | 2.74595620 |
| 28 | Optic disc pallor (HP:0000543) | 2.72328172 |
| 29 | Exercise intolerance (HP:0003546) | 2.69732124 |
| 30 | Pancreatic fibrosis (HP:0100732) | 2.69659249 |
| 31 | Microvesicular hepatic steatosis (HP:0001414) | 2.68760166 |
| 32 | Increased muscle lipid content (HP:0009058) | 2.68585385 |
| 33 | Respiratory failure (HP:0002878) | 2.67230993 |
| 34 | Medial flaring of the eyebrow (HP:0010747) | 2.60223361 |
| 35 | Abnormality of the anterior horn cell (HP:0006802) | 2.55075616 |
| 36 | Degeneration of anterior horn cells (HP:0002398) | 2.55075616 |
| 37 | True hermaphroditism (HP:0010459) | 2.54768526 |
| 38 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.51000398 |
| 39 | Abnormal protein glycosylation (HP:0012346) | 2.49972830 |
| 40 | Abnormal glycosylation (HP:0012345) | 2.49972830 |
| 41 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.49972830 |
| 42 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.49972830 |
| 43 | Respiratory difficulties (HP:0002880) | 2.43324443 |
| 44 | Nephronophthisis (HP:0000090) | 2.41994240 |
| 45 | Methylmalonic acidemia (HP:0002912) | 2.39790805 |
| 46 | Macrocytic anemia (HP:0001972) | 2.39439670 |
| 47 | Leukodystrophy (HP:0002415) | 2.34627818 |
| 48 | Generalized aminoaciduria (HP:0002909) | 2.32170915 |
| 49 | Abnormality of renal resorption (HP:0011038) | 2.31816655 |
| 50 | Colon cancer (HP:0003003) | 2.30245536 |
| 51 | Abnormality of the pons (HP:0007361) | 2.27865122 |
| 52 | Pancytopenia (HP:0001876) | 2.26861460 |
| 53 | Lethargy (HP:0001254) | 2.25963340 |
| 54 | Abnormality of midbrain morphology (HP:0002418) | 2.24200750 |
| 55 | Molar tooth sign on MRI (HP:0002419) | 2.24200750 |
| 56 | Hypothermia (HP:0002045) | 2.21743843 |
| 57 | Renal cortical cysts (HP:0000803) | 2.21209140 |
| 58 | Hypoplasia of the pons (HP:0012110) | 2.21176654 |
| 59 | Pallor (HP:0000980) | 2.13170204 |
| 60 | Oral leukoplakia (HP:0002745) | 2.10926149 |
| 61 | Gait imbalance (HP:0002141) | 2.08770709 |
| 62 | Short tibia (HP:0005736) | 2.07865789 |
| 63 | Methylmalonic aciduria (HP:0012120) | 2.07825816 |
| 64 | CNS demyelination (HP:0007305) | 2.07520646 |
| 65 | Congenital primary aphakia (HP:0007707) | 2.07139302 |
| 66 | Emotional lability (HP:0000712) | 2.02446048 |
| 67 | Glycosuria (HP:0003076) | 1.99697212 |
| 68 | Abnormality of urine glucose concentration (HP:0011016) | 1.99697212 |
| 69 | Abnormality of the renal cortex (HP:0011035) | 1.97799976 |
| 70 | Abnormality of the renal medulla (HP:0100957) | 1.94112250 |
| 71 | Reduced antithrombin III activity (HP:0001976) | 1.91702358 |
| 72 | Nephrogenic diabetes insipidus (HP:0009806) | 1.91185718 |
| 73 | Absent thumb (HP:0009777) | 1.89639081 |
| 74 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.88462969 |
| 75 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.86763320 |
| 76 | Chromsome breakage (HP:0040012) | 1.86376758 |
| 77 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.84767482 |
| 78 | Dicarboxylic aciduria (HP:0003215) | 1.84767482 |
| 79 | Panhypogammaglobulinemia (HP:0003139) | 1.84346484 |
| 80 | Severe combined immunodeficiency (HP:0004430) | 1.81995574 |
| 81 | Hyperphosphaturia (HP:0003109) | 1.81720382 |
| 82 | Meckel diverticulum (HP:0002245) | 1.79431053 |
| 83 | Congenital stationary night blindness (HP:0007642) | 1.78857686 |
| 84 | Abnormality of alanine metabolism (HP:0010916) | 1.78344439 |
| 85 | Hyperalaninemia (HP:0003348) | 1.78344439 |
| 86 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.78344439 |
| 87 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.76852876 |
| 88 | Abnormality of the ileum (HP:0001549) | 1.75768517 |
| 89 | Type II lissencephaly (HP:0007260) | 1.74976301 |
| 90 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.73899483 |
| 91 | Abolished electroretinogram (ERG) (HP:0000550) | 1.73221667 |
| 92 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.71726364 |
| 93 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.71715114 |
| 94 | Increased serum pyruvate (HP:0003542) | 1.70721298 |
| 95 | Type 2 muscle fiber atrophy (HP:0003554) | 1.70681885 |
| 96 | Duplicated collecting system (HP:0000081) | 1.67127174 |
| 97 | Neutropenia (HP:0001875) | 1.66516203 |
| 98 | Cerebellar dysplasia (HP:0007033) | 1.65865602 |
| 99 | Abnormality of methionine metabolism (HP:0010901) | 1.65684573 |
| 100 | IgG deficiency (HP:0004315) | 1.63694892 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 4.92235542 |
| 2 | BUB1 | 2.99520370 |
| 3 | MAP4K2 | 2.86537424 |
| 4 | VRK1 | 2.85053156 |
| 5 | ZAK | 2.82066486 |
| 6 | NUAK1 | 2.69161995 |
| 7 | NME1 | 2.64911687 |
| 8 | STK16 | 2.35513805 |
| 9 | SRPK1 | 2.26940495 |
| 10 | TAOK3 | 2.18091490 |
| 11 | BCKDK | 2.15590070 |
| 12 | MST4 | 2.10997375 |
| 13 | CDC7 | 2.02979921 |
| 14 | WNK3 | 2.01989187 |
| 15 | PBK | 1.92749752 |
| 16 | TRIM28 | 1.74262488 |
| 17 | EIF2AK3 | 1.71148911 |
| 18 | PLK3 | 1.65852614 |
| 19 | EIF2AK1 | 1.60557241 |
| 20 | TAF1 | 1.54433670 |
| 21 | TLK1 | 1.53078095 |
| 22 | PLK4 | 1.48356009 |
| 23 | CCNB1 | 1.47440471 |
| 24 | MAP3K12 | 1.44042128 |
| 25 | DYRK2 | 1.33152057 |
| 26 | NEK1 | 1.29246105 |
| 27 | BCR | 1.25384370 |
| 28 | TNIK | 1.21167841 |
| 29 | KDR | 1.19630887 |
| 30 | ADRBK2 | 1.17277036 |
| 31 | BRSK2 | 1.15838346 |
| 32 | FRK | 1.15372087 |
| 33 | TXK | 1.07546227 |
| 34 | MKNK1 | 1.06676327 |
| 35 | WEE1 | 1.06149186 |
| 36 | CSNK1G3 | 1.04665545 |
| 37 | NME2 | 1.04154517 |
| 38 | ATR | 0.97784354 |
| 39 | MAP3K4 | 0.97106835 |
| 40 | TESK2 | 0.96062487 |
| 41 | TTK | 0.95073925 |
| 42 | DYRK3 | 0.92370836 |
| 43 | FLT3 | 0.92362996 |
| 44 | MUSK | 0.91837437 |
| 45 | DAPK1 | 0.90690080 |
| 46 | BMPR1B | 0.89389674 |
| 47 | CDK19 | 0.88253952 |
| 48 | RPS6KA4 | 0.88143534 |
| 49 | PINK1 | 0.87188197 |
| 50 | MAPK13 | 0.86860661 |
| 51 | GRK1 | 0.86086069 |
| 52 | PLK1 | 0.82964839 |
| 53 | CSNK1G1 | 0.82227397 |
| 54 | IKBKB | 0.82116039 |
| 55 | INSRR | 0.78117001 |
| 56 | CDK8 | 0.76970804 |
| 57 | CSNK1G2 | 0.76606664 |
| 58 | AURKB | 0.76474331 |
| 59 | BMPR2 | 0.75516810 |
| 60 | CLK1 | 0.75143890 |
| 61 | PASK | 0.74700385 |
| 62 | CHEK2 | 0.72303697 |
| 63 | TSSK6 | 0.71640210 |
| 64 | RPS6KA5 | 0.70975504 |
| 65 | EIF2AK2 | 0.70550773 |
| 66 | MAPKAPK3 | 0.68684210 |
| 67 | CSNK1A1L | 0.66537087 |
| 68 | MAP2K7 | 0.64162330 |
| 69 | ERBB3 | 0.63237562 |
| 70 | PDK2 | 0.62695355 |
| 71 | MKNK2 | 0.61210467 |
| 72 | STK4 | 0.61032955 |
| 73 | CSNK2A2 | 0.60698694 |
| 74 | CSNK2A1 | 0.59124219 |
| 75 | KIT | 0.57178918 |
| 76 | TEC | 0.56334838 |
| 77 | NEK2 | 0.52282934 |
| 78 | LIMK1 | 0.47323327 |
| 79 | AURKA | 0.46861217 |
| 80 | CDK3 | 0.46510758 |
| 81 | GRK6 | 0.44484223 |
| 82 | PLK2 | 0.44076915 |
| 83 | OXSR1 | 0.44050623 |
| 84 | PRKCG | 0.43571506 |
| 85 | PHKG2 | 0.43423863 |
| 86 | PHKG1 | 0.43423863 |
| 87 | MARK3 | 0.42699892 |
| 88 | PIM2 | 0.42495440 |
| 89 | MAP4K1 | 0.42317864 |
| 90 | MINK1 | 0.42088916 |
| 91 | CSNK1A1 | 0.41103345 |
| 92 | ATM | 0.39296617 |
| 93 | BRSK1 | 0.37558270 |
| 94 | LYN | 0.36462079 |
| 95 | PKN1 | 0.36283128 |
| 96 | PIK3CG | 0.32810438 |
| 97 | PRKCE | 0.32417304 |
| 98 | ADRBK1 | 0.31618773 |
| 99 | MAPKAPK5 | 0.30660736 |
| 100 | GRK5 | 0.29088970 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.29749368 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 4.27930016 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 3.83623701 |
| 4 | Parkinsons disease_Homo sapiens_hsa05012 | 3.70962950 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 3.19773286 |
| 6 | Protein export_Homo sapiens_hsa03060 | 3.00340532 |
| 7 | Homologous recombination_Homo sapiens_hsa03440 | 2.57615505 |
| 8 | Huntingtons disease_Homo sapiens_hsa05016 | 2.57072726 |
| 9 | Mismatch repair_Homo sapiens_hsa03430 | 2.48175586 |
| 10 | Alzheimers disease_Homo sapiens_hsa05010 | 2.35973026 |
| 11 | DNA replication_Homo sapiens_hsa03030 | 2.29281317 |
| 12 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.09635020 |
| 13 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.08124888 |
| 14 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.05526256 |
| 15 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.97247563 |
| 16 | Spliceosome_Homo sapiens_hsa03040 | 1.96892636 |
| 17 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.88971326 |
| 18 | Base excision repair_Homo sapiens_hsa03410 | 1.87924729 |
| 19 | RNA degradation_Homo sapiens_hsa03018 | 1.74699864 |
| 20 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.73419958 |
| 21 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.61315112 |
| 22 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.58560093 |
| 23 | Asthma_Homo sapiens_hsa05310 | 1.51559152 |
| 24 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.44506251 |
| 25 | Purine metabolism_Homo sapiens_hsa00230 | 1.39257983 |
| 26 | RNA transport_Homo sapiens_hsa03013 | 1.38370425 |
| 27 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.33527227 |
| 28 | Basal transcription factors_Homo sapiens_hsa03022 | 1.32239035 |
| 29 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.31170744 |
| 30 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.30527603 |
| 31 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.27084649 |
| 32 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.19730316 |
| 33 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.17423162 |
| 34 | Phototransduction_Homo sapiens_hsa04744 | 1.10279277 |
| 35 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.09271508 |
| 36 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.09122907 |
| 37 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.04785177 |
| 38 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.00444572 |
| 39 | Peroxisome_Homo sapiens_hsa04146 | 0.98547195 |
| 40 | Allograft rejection_Homo sapiens_hsa05330 | 0.98233533 |
| 41 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.95874405 |
| 42 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.94162211 |
| 43 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.94043333 |
| 44 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.92922398 |
| 45 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.84830859 |
| 46 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.83246013 |
| 47 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.81313553 |
| 48 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.79839535 |
| 49 | Metabolic pathways_Homo sapiens_hsa01100 | 0.79133595 |
| 50 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.77030330 |
| 51 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.75045189 |
| 52 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.74035219 |
| 53 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.73619937 |
| 54 | Cell cycle_Homo sapiens_hsa04110 | 0.73381395 |
| 55 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.70568670 |
| 56 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.68685714 |
| 57 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.66143008 |
| 58 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.62766771 |
| 59 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.61346693 |
| 60 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.60695653 |
| 61 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.59827885 |
| 62 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.59563133 |
| 63 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.56858506 |
| 64 | Olfactory transduction_Homo sapiens_hsa04740 | 0.55883806 |
| 65 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.55695123 |
| 66 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.54884165 |
| 67 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.54761808 |
| 68 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.54650179 |
| 69 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.52456195 |
| 70 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.52063089 |
| 71 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.49476248 |
| 72 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.48583300 |
| 73 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.47833779 |
| 74 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.47251391 |
| 75 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.46599629 |
| 76 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.46320559 |
| 77 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.46145192 |
| 78 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.44624552 |
| 79 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.42209123 |
| 80 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.41820290 |
| 81 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.40391126 |
| 82 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.38729590 |
| 83 | Retinol metabolism_Homo sapiens_hsa00830 | 0.36546169 |
| 84 | Sulfur relay system_Homo sapiens_hsa04122 | 0.35164575 |
| 85 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.34853995 |
| 86 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.33144813 |
| 87 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.33051211 |
| 88 | Carbon metabolism_Homo sapiens_hsa01200 | 0.32656661 |
| 89 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.32566430 |
| 90 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.32551220 |
| 91 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.31435983 |
| 92 | Taste transduction_Homo sapiens_hsa04742 | 0.31229043 |
| 93 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.30714064 |
| 94 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.30020421 |
| 95 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.27182861 |
| 96 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.26897538 |
| 97 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.26344641 |
| 98 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.25568261 |
| 99 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.24880827 |
| 100 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.24448193 |

