PMS2P10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.90982995
2viral transcription (GO:0019083)4.80793719
3pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.75426557
4translational termination (GO:0006415)4.69221770
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.66157840
6cotranslational protein targeting to membrane (GO:0006613)4.58287733
7protein targeting to ER (GO:0045047)4.54497360
8protein localization to endoplasmic reticulum (GO:0070972)4.40858289
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.38873173
10mitochondrial respiratory chain complex I assembly (GO:0032981)4.38873173
11NADH dehydrogenase complex assembly (GO:0010257)4.38873173
12establishment of protein localization to endoplasmic reticulum (GO:0072599)4.36211250
13protein complex biogenesis (GO:0070271)4.27852804
14DNA deamination (GO:0045006)4.13225250
15translational elongation (GO:0006414)4.12664973
16ribosomal large subunit biogenesis (GO:0042273)4.07619580
17ribosomal small subunit biogenesis (GO:0042274)4.06062759
18deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.04807406
19pyrimidine nucleotide catabolic process (GO:0006244)4.03026773
20deoxyribonucleotide catabolic process (GO:0009264)4.00351487
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.97824416
22maturation of SSU-rRNA (GO:0030490)3.93722753
23rRNA modification (GO:0000154)3.93584949
24mitochondrial respiratory chain complex assembly (GO:0033108)3.93170006
25pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.92600707
26microtubule severing (GO:0051013)3.89556249
27deoxyribose phosphate catabolic process (GO:0046386)3.87356810
28viral life cycle (GO:0019058)3.77058149
29translational initiation (GO:0006413)3.76085014
30Arp2/3 complex-mediated actin nucleation (GO:0034314)3.63477304
31deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.61846451
32nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.60494911
33protein neddylation (GO:0045116)3.56216592
34ATP synthesis coupled proton transport (GO:0015986)3.49998262
35energy coupled proton transport, down electrochemical gradient (GO:0015985)3.49998262
36cellular protein complex disassembly (GO:0043624)3.49501986
37negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.49448362
38translation (GO:0006412)3.47458850
39response to pheromone (GO:0019236)3.47314903
40mismatch repair (GO:0006298)3.45631486
41purine nucleotide salvage (GO:0032261)3.45458069
42transcription elongation from RNA polymerase III promoter (GO:0006385)3.44229083
43termination of RNA polymerase III transcription (GO:0006386)3.44229083
44purine deoxyribonucleotide catabolic process (GO:0009155)3.43933060
45nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.43338082
46exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.43127880
47positive regulation of B cell differentiation (GO:0045579)3.41259578
48GTP biosynthetic process (GO:0006183)3.38762384
492-deoxyribonucleotide metabolic process (GO:0009394)3.36954311
50regulation of cellular amino acid metabolic process (GO:0006521)3.35142820
51positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.34919107
52DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.33643129
53organelle disassembly (GO:1903008)3.33528806
54purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.31033060
55deoxyribose phosphate metabolic process (GO:0019692)3.30085304
56signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.23944421
57intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.23944421
58signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.20287719
59signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.20287719
60signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.20287719
61tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.19203257
62RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.19203257
63regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.16385923
64base-excision repair, AP site formation (GO:0006285)3.15853304
65negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.15761561
66centriole replication (GO:0007099)3.14295252
67rRNA methylation (GO:0031167)3.13625809
68oxidative phosphorylation (GO:0006119)3.12199867
69purine-containing compound salvage (GO:0043101)3.07623438
70platelet dense granule organization (GO:0060155)3.07147851
71signal transduction involved in DNA damage checkpoint (GO:0072422)3.06530372
72signal transduction involved in DNA integrity checkpoint (GO:0072401)3.06530372
73cellular component biogenesis (GO:0044085)3.04453749
74UTP metabolic process (GO:0046051)3.03890281
75protein targeting to membrane (GO:0006612)3.03743298
76negative regulation of ligase activity (GO:0051352)3.03556939
77negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.03556939
78signal transduction involved in cell cycle checkpoint (GO:0072395)3.02028119
79aldehyde catabolic process (GO:0046185)3.01613844
80UTP biosynthetic process (GO:0006228)3.01389594
81grooming behavior (GO:0007625)3.01180314
82actin nucleation (GO:0045010)2.99858695
83protein complex disassembly (GO:0043241)2.99833976
84deoxyribonucleotide metabolic process (GO:0009262)2.99525462
85guanosine-containing compound biosynthetic process (GO:1901070)2.97951596
86arginine catabolic process (GO:0006527)2.97165581
87nuclear-transcribed mRNA catabolic process (GO:0000956)2.96356348
88macromolecular complex disassembly (GO:0032984)2.94709899
89purine deoxyribonucleotide metabolic process (GO:0009151)2.91741615
90purine nucleobase biosynthetic process (GO:0009113)2.91460094
91respiratory electron transport chain (GO:0022904)2.90457201
92electron transport chain (GO:0022900)2.89862796
93mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.89221312
94pseudouridine synthesis (GO:0001522)2.88303991
95anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.88197114
96antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.87845910
97heme biosynthetic process (GO:0006783)2.83755422
98protein maturation by protein folding (GO:0022417)2.82225288
99aggressive behavior (GO:0002118)2.81742072
100positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.79509856

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.51438639
2ELF1_17652178_ChIP-ChIP_JURKAT_Human4.05895829
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.04985086
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.75667981
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.65384487
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.63399078
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.57271679
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.42425601
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.12601198
10VDR_23849224_ChIP-Seq_CD4+_Human3.04513487
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.04033678
12FOXP3_21729870_ChIP-Seq_TREG_Human2.92428803
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.90829997
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.87029992
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.72012364
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.71227243
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.63906601
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.60573652
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.58927224
20ELK1_19687146_ChIP-ChIP_HELA_Human2.46101773
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.43475764
22HOXB4_20404135_ChIP-ChIP_EML_Mouse2.31435178
23IRF8_22096565_ChIP-ChIP_GC-B_Human2.31053584
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.22222003
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.20852059
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.14003015
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.12311519
28E2F4_17652178_ChIP-ChIP_JURKAT_Human2.09716946
29DCP1A_22483619_ChIP-Seq_HELA_Human2.07401485
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05827216
31GABP_19822575_ChIP-Seq_HepG2_Human2.03710699
32MYC_19030024_ChIP-ChIP_MESCs_Mouse2.01823536
33GATA1_22025678_ChIP-Seq_K562_Human2.01749622
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.01190862
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.99664347
36TTF2_22483619_ChIP-Seq_HELA_Human1.98087050
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.96115207
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.83721723
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.82670240
40XRN2_22483619_ChIP-Seq_HELA_Human1.80701471
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.80462328
42CIITA_25753668_ChIP-Seq_RAJI_Human1.80286236
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.80005275
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.76684788
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.72470066
46IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.69328518
47MYC_18940864_ChIP-ChIP_HL60_Human1.64525988
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56644209
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53053110
50KDM5A_27292631_Chip-Seq_BREAST_Human1.50480345
51ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46422403
52BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.44779201
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.41915385
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41556122
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40042327
56SPI1_23547873_ChIP-Seq_NB4_Human1.39490810
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.37216048
58CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.36823907
59FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.33735952
60IRF1_19129219_ChIP-ChIP_H3396_Human1.30094231
61MYB_26560356_Chip-Seq_TH2_Human1.29197943
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26605121
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25301783
64CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23257400
65IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18234671
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.17066404
67RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13277308
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10799202
69SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04644890
70PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.04619054
71FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03915858
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03405477
73MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.02684731
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00094901
75CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98071908
76ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97371180
77CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94908203
78ELK1_22589737_ChIP-Seq_MCF10A_Human0.94201101
79STAT4_19710469_ChIP-ChIP_TH1__Mouse0.93472465
80MYCN_18555785_ChIP-Seq_MESCs_Mouse0.93044312
81CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92215632
82TFEB_21752829_ChIP-Seq_HELA_Human0.92021655
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90805679
84TP53_22573176_ChIP-Seq_HFKS_Human0.90184738
85NANOG_18555785_ChIP-Seq_MESCs_Mouse0.89495724
86E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87676873
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85886858
88FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.85610544
89VDR_22108803_ChIP-Seq_LS180_Human0.85314545
90IGF1R_20145208_ChIP-Seq_DFB_Human0.83942931
91ELF5_23300383_ChIP-Seq_T47D_Human0.82352409
92MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.82194078
93EWS_26573619_Chip-Seq_HEK293_Human0.81548636
94MYC_22102868_ChIP-Seq_BL_Human0.81437787
95SCL_19346495_ChIP-Seq_HPC-7_Human0.80584850
96GATA3_27048872_Chip-Seq_THYMUS_Human0.80122414
97FOXA1_27270436_Chip-Seq_PROSTATE_Human0.79377309
98FOXA1_25329375_ChIP-Seq_VCAP_Human0.79377309
99MYB_26560356_Chip-Seq_TH1_Human0.78756504
100SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.77695431

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009697_abnormal_copulation3.61716904
2MP0001835_abnormal_antigen_presentation3.61520841
3MP0005645_abnormal_hypothalamus_physiol3.48188161
4MP0003806_abnormal_nucleotide_metabolis3.34095289
5MP0005075_abnormal_melanosome_morpholog3.09423675
6MP0002132_abnormal_respiratory_system2.89683158
7MP0004147_increased_porphyrin_level2.86882820
8MP0008058_abnormal_DNA_repair2.81766855
9MP0006036_abnormal_mitochondrial_physio2.64777851
10MP0003186_abnormal_redox_activity2.45064244
11MP0010094_abnormal_chromosome_stability2.43956385
12MP0000685_abnormal_immune_system2.21164111
13MP0003718_maternal_effect2.17058680
14MP0009379_abnormal_foot_pigmentation2.14089147
15MP0009785_altered_susceptibility_to2.11268314
16MP0001727_abnormal_embryo_implantation2.05470312
17MP0005464_abnormal_platelet_physiology2.02401588
18MP0006035_abnormal_mitochondrial_morpho2.01179296
19MP0003787_abnormal_imprinting1.95237502
20MP0005084_abnormal_gallbladder_morpholo1.94381045
21MP0002736_abnormal_nociception_after1.88423860
22MP0005671_abnormal_response_to1.77000048
23MP0008789_abnormal_olfactory_epithelium1.75475876
24MP0000372_irregular_coat_pigmentation1.72851910
25MP0003763_abnormal_thymus_physiology1.72507346
26MP0002837_dystrophic_cardiac_calcinosis1.71973039
27MP0003693_abnormal_embryo_hatching1.55613406
28MP0002166_altered_tumor_susceptibility1.51002137
29MP0005000_abnormal_immune_tolerance1.46966673
30MP0006292_abnormal_olfactory_placode1.44282271
31MP0001800_abnormal_humoral_immune1.43013248
32MP0002138_abnormal_hepatobiliary_system1.41001385
33MP0000689_abnormal_spleen_morphology1.40037222
34MP0002653_abnormal_ependyma_morphology1.36338003
35MP0002398_abnormal_bone_marrow1.35215001
36MP0002148_abnormal_hypersensitivity_rea1.31682627
37MP0003786_premature_aging1.31252727
38MP0003252_abnormal_bile_duct1.30836163
39MP0001819_abnormal_immune_cell1.29800488
40MP0002452_abnormal_antigen_presenting1.29717374
41MP0001529_abnormal_vocalization1.29073731
42MP0002420_abnormal_adaptive_immunity1.27792292
43MP0001905_abnormal_dopamine_level1.27225466
44MP0002095_abnormal_skin_pigmentation1.25393596
45MP0002254_reproductive_system_inflammat1.21739660
46MP0008872_abnormal_physiological_respon1.19382123
47MP0003077_abnormal_cell_cycle1.18198550
48MP0005646_abnormal_pituitary_gland1.18072730
49MP0002396_abnormal_hematopoietic_system1.18057967
50MP0002160_abnormal_reproductive_system1.17672906
51MP0002006_tumorigenesis1.17529516
52MP0003283_abnormal_digestive_organ1.17310854
53MP0002723_abnormal_immune_serum1.16973159
54MP0005387_immune_system_phenotype1.16288992
55MP0001790_abnormal_immune_system1.16288992
56MP0005499_abnormal_olfactory_system1.15292390
57MP0005394_taste/olfaction_phenotype1.15292390
58MP0001873_stomach_inflammation1.14272628
59MP0005408_hypopigmentation1.14192375
60MP0002019_abnormal_tumor_incidence1.13954550
61MP0002722_abnormal_immune_system1.12917791
62MP0005025_abnormal_response_to1.11448707
63MP0005636_abnormal_mineral_homeostasis1.10140426
64MP0000716_abnormal_immune_system1.08990773
65MP0006082_CNS_inflammation1.07390413
66MP0000358_abnormal_cell_content/1.07096381
67MP0002405_respiratory_system_inflammati1.06943780
68MP0002429_abnormal_blood_cell1.05900264
69MP0004142_abnormal_muscle_tone1.03009856
70MP0008875_abnormal_xenobiotic_pharmacok1.00597631
71MP0009333_abnormal_splenocyte_physiolog0.99213382
72MP0006072_abnormal_retinal_apoptosis0.95961810
73MP0003111_abnormal_nucleus_morphology0.91865124
74MP0009764_decreased_sensitivity_to0.91115891
75MP0002234_abnormal_pharynx_morphology0.90856301
76MP0002876_abnormal_thyroid_physiology0.90349531
77MP0005165_increased_susceptibility_to0.90214148
78MP0003121_genomic_imprinting0.88441721
79MP0008877_abnormal_DNA_methylation0.84062121
80MP0001968_abnormal_touch/_nociception0.83699080
81MP0004957_abnormal_blastocyst_morpholog0.81887624
82MP0008007_abnormal_cellular_replicative0.80544304
83MP0008932_abnormal_embryonic_tissue0.78626650
84MP0008469_abnormal_protein_level0.78606683
85MP0005389_reproductive_system_phenotype0.76565205
86MP0003866_abnormal_defecation0.75014791
87MP0005395_other_phenotype0.74748037
88MP0001845_abnormal_inflammatory_respons0.74745331
89MP0001542_abnormal_bone_strength0.73584940
90MP0002090_abnormal_vision0.71424409
91MP0009763_increased_sensitivity_to0.71264721
92MP0003656_abnormal_erythrocyte_physiolo0.70781350
93MP0002928_abnormal_bile_duct0.70618147
94MP0005220_abnormal_exocrine_pancreas0.70384211
95MP0005310_abnormal_salivary_gland0.70073513
96MP0000313_abnormal_cell_death0.69929551
97MP0005332_abnormal_amino_acid0.69777569
98MP0000490_abnormal_crypts_of0.69628743
99MP0009053_abnormal_anal_canal0.69600740
100MP0005330_cardiomyopathy0.67225512

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)5.26663971
2Panhypogammaglobulinemia (HP:0003139)4.52195159
3Acute encephalopathy (HP:0006846)4.37875479
4Acute necrotizing encephalopathy (HP:0006965)4.31704543
5Hepatocellular necrosis (HP:0001404)4.25001732
6Mitochondrial inheritance (HP:0001427)4.19146772
7Abnormal mitochondria in muscle tissue (HP:0008316)4.17963164
8Renal Fanconi syndrome (HP:0001994)4.05933564
9Increased hepatocellular lipid droplets (HP:0006565)4.01664445
10Increased CSF lactate (HP:0002490)3.91326274
11Lipid accumulation in hepatocytes (HP:0006561)3.75363251
12Hepatic necrosis (HP:0002605)3.65148071
13Progressive macrocephaly (HP:0004481)3.53877713
14Agammaglobulinemia (HP:0004432)3.41794069
15Severe combined immunodeficiency (HP:0004430)3.31086337
16Reticulocytopenia (HP:0001896)3.26005998
17Increased intramyocellular lipid droplets (HP:0012240)3.25274265
18B lymphocytopenia (HP:0010976)3.24841573
19Microvesicular hepatic steatosis (HP:0001414)3.08214729
20Abnormality of B cell number (HP:0010975)2.97588552
21Abnormality of the heme biosynthetic pathway (HP:0010472)2.96166114
22Increased serum lactate (HP:0002151)2.95495852
23Cerebral edema (HP:0002181)2.87986045
24Abnormality of cells of the erythroid lineage (HP:0012130)2.80086015
25Abnormality of the prostate (HP:0008775)2.76031489
26Increased muscle lipid content (HP:0009058)2.73212198
27Combined immunodeficiency (HP:0005387)2.71635929
28Lactic acidosis (HP:0003128)2.63440798
29Pancytopenia (HP:0001876)2.61650499
30Abnormal number of erythroid precursors (HP:0012131)2.61241121
31Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.59515708
32Hypoproteinemia (HP:0003075)2.54872907
333-Methylglutaconic aciduria (HP:0003535)2.53381403
34Cerebral palsy (HP:0100021)2.51869108
35Abnormality of renal resorption (HP:0011038)2.50709880
36Exertional dyspnea (HP:0002875)2.48371960
37Molar tooth sign on MRI (HP:0002419)2.45932357
38Abnormality of midbrain morphology (HP:0002418)2.45932357
39Type I transferrin isoform profile (HP:0003642)2.43060603
40Hypoplasia of the thymus (HP:0000778)2.42847999
41Elevated erythrocyte sedimentation rate (HP:0003565)2.38299831
42Obstructive lung disease (HP:0006536)2.38087247
43Chronic obstructive pulmonary disease (HP:0006510)2.38087247
44Decreased activity of mitochondrial respiratory chain (HP:0008972)2.36660199
45Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.36660199
46Abnormality of lateral ventricle (HP:0030047)2.32515142
47Recurrent viral infections (HP:0004429)2.29746730
48Chromosomal breakage induced by crosslinking agents (HP:0003221)2.27368098
49Pancreatic fibrosis (HP:0100732)2.26509377
50Prolonged neonatal jaundice (HP:0006579)2.21696897
51Exercise intolerance (HP:0003546)2.21185321
52Microretrognathia (HP:0000308)2.19023688
53Emotional lability (HP:0000712)2.15312847
54Thrombocytosis (HP:0001894)2.14991733
55Pancreatic cysts (HP:0001737)2.12442089
56Leukodystrophy (HP:0002415)2.12278412
57Prolonged bleeding time (HP:0003010)2.09378551
58Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.08397333
59Dynein arm defect of respiratory motile cilia (HP:0012255)2.08058820
60Absent/shortened dynein arms (HP:0200106)2.08058820
61Increased serum pyruvate (HP:0003542)2.07892730
62Respiratory failure (HP:0002878)2.06613441
63Medial flaring of the eyebrow (HP:0010747)2.06345456
64Thyroiditis (HP:0100646)2.03988116
65Aplasia/Hypoplasia of the thymus (HP:0010515)2.02292582
66Abnormal protein glycosylation (HP:0012346)2.01800491
67Abnormal glycosylation (HP:0012345)2.01800491
68Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.01800491
69Abnormal protein N-linked glycosylation (HP:0012347)2.01800491
70CNS hypomyelination (HP:0003429)2.01519316
71Meningitis (HP:0001287)1.98245183
72Neutropenia (HP:0001875)1.97630722
73CNS demyelination (HP:0007305)1.97568283
74Posterior subcapsular cataract (HP:0007787)1.96768898
75Chronic otitis media (HP:0000389)1.95898713
76Cerebral hypomyelination (HP:0006808)1.95546253
77Oral leukoplakia (HP:0002745)1.95058588
78Lethargy (HP:0001254)1.93108165
79Brushfield spots (HP:0001088)1.92519071
80Short tibia (HP:0005736)1.90215238
81Chromsome breakage (HP:0040012)1.87435889
82Pallor (HP:0000980)1.86284152
83Optic disc pallor (HP:0000543)1.84947090
84Abnormality of T cells (HP:0002843)1.82974888
85Median cleft lip (HP:0000161)1.82470407
86Macrocytic anemia (HP:0001972)1.81016105
87Abnormality of methionine metabolism (HP:0010901)1.78663153
88Type 2 muscle fiber atrophy (HP:0003554)1.76930739
89Progressive microcephaly (HP:0000253)1.76458269
90IgM deficiency (HP:0002850)1.76350907
91Stomatitis (HP:0010280)1.75674133
92Congenital primary aphakia (HP:0007707)1.74590622
93Abnormality of reticulocytes (HP:0004312)1.74331352
94Abnormality of glycolysis (HP:0004366)1.73168940
95Abnormality of T cell physiology (HP:0011840)1.72609840
96Abnormality of aspartate family amino acid metabolism (HP:0010899)1.72199555
97Hyperglycinemia (HP:0002154)1.70549296
98Poor suck (HP:0002033)1.69139756
99Lymphoma (HP:0002665)1.68878165
100Abnormality of male internal genitalia (HP:0000022)1.68876430

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.05153775
2STK163.64636216
3MST43.31930672
4CCNB13.24935564
5SCYL23.12200319
6NUAK13.11539298
7TESK23.04476869
8MAPKAPK32.84198726
9NME22.75591066
10PIM22.63621085
11KDR2.41789965
12BCKDK2.38650529
13EIF2AK12.37762773
14NME12.13362819
15MAP4K11.96856750
16VRK11.91553834
17EIF2AK31.84781920
18ZAK1.71138195
19TLK11.62255181
20MAP4K21.61518756
21BMPR1B1.56557777
22TAOK31.47919588
23DAPK11.40573182
24TEC1.38669489
25SRPK11.37484371
26ARAF1.36862314
27BUB11.34911708
28CDC71.34622365
29RPS6KB21.31430397
30BTK1.25197845
31PBK1.20076616
32TESK11.18524733
33CDK191.14695480
34KIT1.12551380
35ILK1.12437138
36LRRK21.10020133
37TBK11.06928200
38DAPK31.03149013
39PIK3CA0.96656257
40WEE10.96217100
41BMPR20.91510071
42PLK40.90811466
43CSNK1G30.88961004
44IKBKB0.88095297
45AURKA0.83269938
46EIF2AK20.82869935
47TAOK20.82609678
48ITK0.80852191
49DYRK20.75270494
50PRKCQ0.74348365
51SYK0.73561194
52TXK0.73413482
53LIMK10.73038805
54RAF10.71911711
55LYN0.71756358
56RPS6KA50.70894277
57CSF1R0.67831543
58CSNK1G20.63682599
59AURKB0.60479492
60FLT30.60264225
61ATR0.59258129
62STK40.58571825
63CDK90.58506305
64PLK10.58346042
65JAK30.57510366
66CDK70.56301082
67CSNK1G10.54041053
68PAK10.53713057
69PINK10.53436382
70CDK80.53195854
71LCK0.52110569
72TGFBR10.50957239
73LMTK20.50717306
74CSNK1A1L0.49587242
75TAF10.49182107
76MAPKAPK50.49175608
77CSNK2A10.48561663
78CSNK2A20.46637191
79ABL10.46360774
80HIPK20.45512010
81INSRR0.44994330
82PASK0.40962746
83BRAF0.40033878
84EPHB20.39873244
85MUSK0.38644666
86DMPK0.37710211
87MATK0.37364170
88BRSK20.35938549
89GRK10.35563943
90ADRBK20.35471065
91PRKG20.35020579
92GRK50.33770459
93MAP3K140.33724252
94INSR0.33541159
95NEK10.32312512
96FRK0.31473807
97IKBKE0.30733857
98CHEK20.30307911
99MAPK30.27114475
100MAP2K60.25993438

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.08362484
2Proteasome_Homo sapiens_hsa030504.05820591
3Protein export_Homo sapiens_hsa030603.36057264
4Asthma_Homo sapiens_hsa053102.99634876
5Oxidative phosphorylation_Homo sapiens_hsa001902.78917147
6Parkinsons disease_Homo sapiens_hsa050122.55188839
7RNA polymerase_Homo sapiens_hsa030202.39819380
8Primary immunodeficiency_Homo sapiens_hsa053402.33091017
9Allograft rejection_Homo sapiens_hsa053302.30768507
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.18135114
11Graft-versus-host disease_Homo sapiens_hsa053322.13534446
12Autoimmune thyroid disease_Homo sapiens_hsa053202.11086994
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.01451259
14Type I diabetes mellitus_Homo sapiens_hsa049402.00372135
15Sulfur relay system_Homo sapiens_hsa041222.00208780
16Fatty acid elongation_Homo sapiens_hsa000621.95316241
17DNA replication_Homo sapiens_hsa030301.94202920
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.93796922
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.82953436
20Base excision repair_Homo sapiens_hsa034101.76973744
21Sulfur metabolism_Homo sapiens_hsa009201.63668871
22Pyrimidine metabolism_Homo sapiens_hsa002401.59659950
23RNA degradation_Homo sapiens_hsa030181.59439425
24Homologous recombination_Homo sapiens_hsa034401.59301143
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.56761775
26Huntingtons disease_Homo sapiens_hsa050161.56531911
27Mismatch repair_Homo sapiens_hsa034301.54781675
28Nucleotide excision repair_Homo sapiens_hsa034201.45745934
29Alzheimers disease_Homo sapiens_hsa050101.43085643
30Fanconi anemia pathway_Homo sapiens_hsa034601.41902380
31Spliceosome_Homo sapiens_hsa030401.35214154
32Systemic lupus erythematosus_Homo sapiens_hsa053221.30912433
33Antigen processing and presentation_Homo sapiens_hsa046121.29132049
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.27558233
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26856088
36Peroxisome_Homo sapiens_hsa041461.24044384
37Propanoate metabolism_Homo sapiens_hsa006401.23627115
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18832286
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.18625302
40Viral myocarditis_Homo sapiens_hsa054161.11717588
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.07211566
42Purine metabolism_Homo sapiens_hsa002301.07176873
43Non-homologous end-joining_Homo sapiens_hsa034501.06396555
44One carbon pool by folate_Homo sapiens_hsa006701.04259414
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03041772
46Hematopoietic cell lineage_Homo sapiens_hsa046401.02077993
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00707931
48RNA transport_Homo sapiens_hsa030130.98601403
49Carbon metabolism_Homo sapiens_hsa012000.97767687
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96030152
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92797001
52Basal transcription factors_Homo sapiens_hsa030220.92751566
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91667315
54Butanoate metabolism_Homo sapiens_hsa006500.88415122
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86756109
56Rheumatoid arthritis_Homo sapiens_hsa053230.86206260
57Herpes simplex infection_Homo sapiens_hsa051680.81332312
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.81129391
59Pentose phosphate pathway_Homo sapiens_hsa000300.79258365
60Biosynthesis of amino acids_Homo sapiens_hsa012300.77859644
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71837431
62Pyruvate metabolism_Homo sapiens_hsa006200.70004234
63Caffeine metabolism_Homo sapiens_hsa002320.69836577
64N-Glycan biosynthesis_Homo sapiens_hsa005100.68650766
65Tyrosine metabolism_Homo sapiens_hsa003500.67242057
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.65779989
67Metabolic pathways_Homo sapiens_hsa011000.65548185
68Cardiac muscle contraction_Homo sapiens_hsa042600.64773022
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62522263
70Leishmaniasis_Homo sapiens_hsa051400.61835780
71Epstein-Barr virus infection_Homo sapiens_hsa051690.59061658
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57278135
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.52870929
74Shigellosis_Homo sapiens_hsa051310.51914522
75Regulation of autophagy_Homo sapiens_hsa041400.51833796
76Glutathione metabolism_Homo sapiens_hsa004800.51767915
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.47332530
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.46925045
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45639964
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45608806
81Chemical carcinogenesis_Homo sapiens_hsa052040.44687423
82Cell cycle_Homo sapiens_hsa041100.42585143
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40206018
84Staphylococcus aureus infection_Homo sapiens_hsa051500.39717855
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39074590
86Arachidonic acid metabolism_Homo sapiens_hsa005900.36722877
87mRNA surveillance pathway_Homo sapiens_hsa030150.35830095
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34980146
89p53 signaling pathway_Homo sapiens_hsa041150.34957635
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34073298
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33007702
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32855456
93Alcoholism_Homo sapiens_hsa050340.31409676
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.29640971
95Linoleic acid metabolism_Homo sapiens_hsa005910.28611437
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26540323
97Retinol metabolism_Homo sapiens_hsa008300.26426139
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.25537164
99Oocyte meiosis_Homo sapiens_hsa041140.22707226
100Folate biosynthesis_Homo sapiens_hsa007900.22533643

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