PMS2P11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1leukotriene biosynthetic process (GO:0019370)8.76129218
2leukotriene metabolic process (GO:0006691)5.55704601
3regulation of B cell receptor signaling pathway (GO:0050855)5.14654472
4positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.11522851
5response to pheromone (GO:0019236)5.06753642
6protein targeting to Golgi (GO:0000042)5.05124634
7Arp2/3 complex-mediated actin nucleation (GO:0034314)5.02261977
8establishment of protein localization to Golgi (GO:0072600)4.83212213
9retrograde transport, vesicle recycling within Golgi (GO:0000301)4.72247412
10one-carbon compound transport (GO:0019755)4.63556909
11icosanoid biosynthetic process (GO:0046456)4.62645215
12fatty acid derivative biosynthetic process (GO:1901570)4.62645215
13cytidine metabolic process (GO:0046087)4.55619217
14cytidine catabolic process (GO:0006216)4.55619217
15cytidine deamination (GO:0009972)4.55619217
16actin nucleation (GO:0045010)4.39750295
17positive regulation of granulocyte differentiation (GO:0030854)4.38040885
18pyrimidine ribonucleoside catabolic process (GO:0046133)4.37503782
19glutathione metabolic process (GO:0006749)4.28601357
20DNA deamination (GO:0045006)4.25516676
21negative regulation of calcium ion-dependent exocytosis (GO:0045955)4.24800413
22regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.24701172
23growth hormone secretion (GO:0030252)4.16966813
24glutathione biosynthetic process (GO:0006750)4.11278092
25DNA double-strand break processing (GO:0000729)4.08417222
26positive regulation of growth hormone secretion (GO:0060124)3.98370096
27T cell migration (GO:0072678)3.96343048
28negative T cell selection (GO:0043383)3.88888114
29nonribosomal peptide biosynthetic process (GO:0019184)3.82244944
30protein localization to Golgi apparatus (GO:0034067)3.67012884
31unsaturated fatty acid biosynthetic process (GO:0006636)3.64544816
32cellular response to interleukin-15 (GO:0071350)3.59954220
33mitochondrial calcium ion transport (GO:0006851)3.55697659
34nucleoside diphosphate catabolic process (GO:0009134)3.55314811
35response to lipoprotein particle (GO:0055094)3.53216118
36regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.49053330
37platelet dense granule organization (GO:0060155)3.46756015
38purine deoxyribonucleotide catabolic process (GO:0009155)3.45346801
39cysteine metabolic process (GO:0006534)3.42792812
40negative regulation of T cell apoptotic process (GO:0070233)3.40158784
41regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.38705036
42DNA demethylation (GO:0080111)3.36246548
43regulation of T cell receptor signaling pathway (GO:0050856)3.35792739
44* mismatch repair (GO:0006298)3.33579553
45detection of light stimulus involved in sensory perception (GO:0050962)3.30497328
46detection of light stimulus involved in visual perception (GO:0050908)3.30497328
47regulation of gamma-delta T cell differentiation (GO:0045586)3.28702829
48positive regulation of gamma-delta T cell activation (GO:0046645)3.24759509
49embryonic process involved in female pregnancy (GO:0060136)3.23734058
50regulation of regulatory T cell differentiation (GO:0045589)3.23277365
51negative regulation of JAK-STAT cascade (GO:0046426)3.22053062
52DNA dealkylation (GO:0035510)3.19708418
53regulation of establishment of cell polarity (GO:2000114)3.17538846
54oligosaccharide biosynthetic process (GO:0009312)3.09606904
55positive T cell selection (GO:0043368)3.07495838
56negative regulation of neurotransmitter secretion (GO:0046929)3.05580958
57cytolysis (GO:0019835)2.99245866
58positive regulation of alpha-beta T cell proliferation (GO:0046641)2.97714423
59response to UV-C (GO:0010225)2.97706404
60phospholipid homeostasis (GO:0055091)2.95209862
61nerve growth factor signaling pathway (GO:0038180)2.93293094
62intra-Golgi vesicle-mediated transport (GO:0006891)2.91677273
63negative regulation of neurotransmitter transport (GO:0051589)2.89441652
64peptide biosynthetic process (GO:0043043)2.89387845
65regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.84500689
66negative thymic T cell selection (GO:0045060)2.82677985
67thrombin receptor signaling pathway (GO:0070493)2.82518705
68nuclear envelope reassembly (GO:0031468)2.76260876
69mitotic nuclear envelope reassembly (GO:0007084)2.76260876
70regulation of alpha-beta T cell proliferation (GO:0046640)2.74791535
71response to interleukin-15 (GO:0070672)2.73584913
72amyloid precursor protein catabolic process (GO:0042987)2.73375767
73definitive hemopoiesis (GO:0060216)2.71319437
74response to nitrosative stress (GO:0051409)2.70111036
75purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.65071206
76dopamine transport (GO:0015872)2.64315584
77positive regulation of B cell differentiation (GO:0045579)2.62575020
78positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.61839090
79negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.61638387
80regulation of cellular extravasation (GO:0002691)2.60806551
81regulation of granulocyte differentiation (GO:0030852)2.60338543
82NIK/NF-kappaB signaling (GO:0038061)2.59650192
83negative regulation of T cell receptor signaling pathway (GO:0050860)2.59029722
84regulation of gamma-delta T cell activation (GO:0046643)2.58915220
85regulation of establishment or maintenance of cell polarity (GO:0032878)2.58683908
86positive regulation of vasculogenesis (GO:2001214)2.58217229
87negative regulation of heart rate (GO:0010459)2.57070558
88regulation of germinal center formation (GO:0002634)2.56567610
89T cell receptor signaling pathway (GO:0050852)2.53876974
90ribosomal small subunit assembly (GO:0000028)2.53476268
91histone mRNA catabolic process (GO:0071044)2.53023621
92T cell costimulation (GO:0031295)2.52540911
93synaptic transmission, dopaminergic (GO:0001963)2.51982379
94bundle of His cell to Purkinje myocyte communication (GO:0086069)2.51549069
95positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.51019714
96lymphocyte costimulation (GO:0031294)2.49064001
97regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.48869611
98positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.47395258
99positive regulation of natural killer cell mediated immunity (GO:0002717)2.46556938
100positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.44484081

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.79967741
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.07520239
3IGF1R_20145208_ChIP-Seq_DFB_Human3.88882298
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.74925527
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.31801818
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.16200349
7TAF15_26573619_Chip-Seq_HEK293_Human2.72482079
8SCL_19346495_ChIP-Seq_HPC-7_Human2.53425318
9GBX2_23144817_ChIP-Seq_PC3_Human2.50170333
10VDR_22108803_ChIP-Seq_LS180_Human2.39746447
11ZNF274_21170338_ChIP-Seq_K562_Hela2.37424578
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.29029510
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.28571003
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.17490412
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12115089
16MYB_26560356_Chip-Seq_TH2_Human2.10599531
17FUS_26573619_Chip-Seq_HEK293_Human2.07365408
18RUNX_20019798_ChIP-Seq_JUKART_Human2.03322067
19ELF1_17652178_ChIP-ChIP_JURKAT_Human1.99765774
20SMAD_19615063_ChIP-ChIP_OVARY_Human1.90471767
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.88291402
22SUZ12_27294783_Chip-Seq_NPCs_Mouse1.81975140
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.77017348
24ER_23166858_ChIP-Seq_MCF-7_Human1.76500388
25GATA1_22025678_ChIP-Seq_K562_Human1.75263474
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70728527
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67263058
28GATA3_26560356_Chip-Seq_TH2_Human1.66020884
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.63051175
30BCAT_22108803_ChIP-Seq_LS180_Human1.57235626
31CBP_20019798_ChIP-Seq_JUKART_Human1.53844940
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53844940
33TP53_22573176_ChIP-Seq_HFKS_Human1.53449578
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46137590
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.44307182
36GATA3_27048872_Chip-Seq_THYMUS_Human1.44229350
37EWS_26573619_Chip-Seq_HEK293_Human1.44214176
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42658512
39VDR_23849224_ChIP-Seq_CD4+_Human1.38856111
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37837861
41IRF1_19129219_ChIP-ChIP_H3396_Human1.36510731
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.36366613
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34544037
44TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.27008928
45P300_19829295_ChIP-Seq_ESCs_Human1.26737232
46CRX_20693478_ChIP-Seq_RETINA_Mouse1.24504496
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.23751453
48MYB_26560356_Chip-Seq_TH1_Human1.22733045
49TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.18148705
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17508085
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15953237
52FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13986987
53RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.13929436
54CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13434446
55FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13345250
56CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12122447
57TCF4_22108803_ChIP-Seq_LS180_Human1.11978601
58GATA3_26560356_Chip-Seq_TH1_Human1.10103749
59IRF8_27001747_Chip-Seq_BMDM_Mouse1.09376668
60PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.08601678
61CDX2_22108803_ChIP-Seq_LS180_Human1.08113277
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07935099
63WDR5_24793694_ChIP-Seq_LNCAP_Human1.07732470
64SPI1_23547873_ChIP-Seq_NB4_Human1.07118169
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06906930
66PRDM14_20953172_ChIP-Seq_ESCs_Human1.06837211
67PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04789797
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04652501
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.04652501
70EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04643152
71OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03035647
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02568695
73NMYC_18555785_Chip-Seq_ESCs_Mouse1.02555476
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02448779
75PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01918612
76SMAD1_18555785_Chip-Seq_ESCs_Mouse0.99855764
77ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97631682
78P300_18555785_Chip-Seq_ESCs_Mouse0.97145263
79SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.94209631
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93999400
81OCT4_18555785_Chip-Seq_ESCs_Mouse0.92988015
82MYC_18940864_ChIP-ChIP_HL60_Human0.91890949
83STAT3_23295773_ChIP-Seq_U87_Human0.91490952
84GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.91352285
85EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89773858
86ZFX_18555785_Chip-Seq_ESCs_Mouse0.89034918
87NANOG_19829295_ChIP-Seq_ESCs_Human0.88849699
88SOX2_19829295_ChIP-Seq_ESCs_Human0.88849699
89MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.88764153
90STAT3_18555785_Chip-Seq_ESCs_Mouse0.88712620
91PU1_27457419_Chip-Seq_LIVER_Mouse0.88695136
92AR_20517297_ChIP-Seq_VCAP_Human0.87961413
93TCF4_23295773_ChIP-Seq_U87_Human0.87745551
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87316196
95GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87204114
96LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.87183293
97SMAD3_21741376_ChIP-Seq_EPCs_Human0.86610394
98CTCF_18555785_Chip-Seq_ESCs_Mouse0.85865265
99FLI1_21867929_ChIP-Seq_TH2_Mouse0.85817813
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85655868

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.40951822
2MP0003195_calcinosis3.23149213
3MP0002009_preneoplasia3.18331726
4MP0002166_altered_tumor_susceptibility3.08308408
5MP0003763_abnormal_thymus_physiology2.78103710
6MP0008995_early_reproductive_senescence2.64666623
7MP0000569_abnormal_digit_pigmentation2.53671847
8MP0006054_spinal_hemorrhage2.47889799
9MP0001835_abnormal_antigen_presentation2.43193000
10MP0008877_abnormal_DNA_methylation2.42829528
11MP0002102_abnormal_ear_morphology2.41818271
12MP0008004_abnormal_stomach_pH2.21719561
13MP0004147_increased_porphyrin_level2.21577305
14MP0003045_fibrosis2.16689707
15MP0005075_abnormal_melanosome_morpholog2.11401605
16MP0000465_gastrointestinal_hemorrhage2.11066478
17MP0000013_abnormal_adipose_tissue2.08139993
18MP0002006_tumorigenesis2.08051040
19MP0003786_premature_aging2.00497343
20MP0003183_abnormal_peptide_metabolism2.00284846
21MP0001800_abnormal_humoral_immune1.96397190
22MP0009785_altered_susceptibility_to1.88203129
23MP0002163_abnormal_gland_morphology1.86346161
24MP0005000_abnormal_immune_tolerance1.84963367
25MP0003283_abnormal_digestive_organ1.79154963
26MP0001501_abnormal_sleep_pattern1.75121391
27MP0003191_abnormal_cellular_cholesterol1.71483022
28MP0003252_abnormal_bile_duct1.70535034
29MP0003866_abnormal_defecation1.69031318
30MP0006082_CNS_inflammation1.66755080
31MP0002723_abnormal_immune_serum1.55158758
32MP0002736_abnormal_nociception_after1.53084591
33MP0009333_abnormal_splenocyte_physiolog1.52155398
34MP0002420_abnormal_adaptive_immunity1.51040363
35MP0005464_abnormal_platelet_physiology1.49267733
36MP0005379_endocrine/exocrine_gland_phen1.49166898
37MP0001819_abnormal_immune_cell1.47336935
38MP0002933_joint_inflammation1.47005817
39MP0005645_abnormal_hypothalamus_physiol1.46556572
40MP0002405_respiratory_system_inflammati1.45970981
41MP0003724_increased_susceptibility_to1.43300861
42MP0003787_abnormal_imprinting1.42739593
43MP0005025_abnormal_response_to1.42065005
44MP0002148_abnormal_hypersensitivity_rea1.41170429
45MP0005084_abnormal_gallbladder_morpholo1.40536166
46MP0000613_abnormal_salivary_gland1.38657208
47MP0000689_abnormal_spleen_morphology1.37084249
48MP0002452_abnormal_antigen_presenting1.36724151
49MP0002398_abnormal_bone_marrow1.36451590
50MP0009697_abnormal_copulation1.35025772
51MP0001873_stomach_inflammation1.30904203
52MP0002138_abnormal_hepatobiliary_system1.30118666
53MP0004145_abnormal_muscle_electrophysio1.29081322
54MP0000716_abnormal_immune_system1.24510139
55MP0000372_irregular_coat_pigmentation1.24427628
56MP0006276_abnormal_autonomic_nervous1.21640030
57MP0001664_abnormal_digestion1.19294457
58MP0001661_extended_life_span1.17616826
59MP0002909_abnormal_adrenal_gland1.14024523
60MP0002722_abnormal_immune_system1.12619593
61MP0003436_decreased_susceptibility_to1.09080960
62MP0002822_catalepsy1.08105639
63MP0009384_cardiac_valve_regurgitation1.07855880
64MP0010155_abnormal_intestine_physiology1.06268545
65MP0005085_abnormal_gallbladder_physiolo1.04882491
66MP0005551_abnormal_eye_electrophysiolog1.03612995
67MP0004381_abnormal_hair_follicle1.03165322
68MP0002136_abnormal_kidney_physiology1.02751954
69MP0000371_diluted_coat_color1.00141198
70MP0004133_heterotaxia0.99522051
71MP0000858_altered_metastatic_potential0.97601589
72MP0004484_altered_response_of0.95932656
73MP0000703_abnormal_thymus_morphology0.94064552
74MP0003567_abnormal_fetal_cardiomyocyte0.94058345
75MP0002429_abnormal_blood_cell0.93769289
76MP0005253_abnormal_eye_physiology0.92924497
77MP0005646_abnormal_pituitary_gland0.92314708
78MP0000516_abnormal_urinary_system0.91701933
79MP0005367_renal/urinary_system_phenotyp0.91701933
80MP0004947_skin_inflammation0.90680307
81MP0005332_abnormal_amino_acid0.90335094
82MP0000015_abnormal_ear_pigmentation0.88769488
83MP0002168_other_aberrant_phenotype0.87444067
84MP0002132_abnormal_respiratory_system0.86677944
85MP0003279_aneurysm0.86509891
86MP0002095_abnormal_skin_pigmentation0.83725773
87MP0002419_abnormal_innate_immunity0.81699366
88MP0001968_abnormal_touch/_nociception0.80988713
89MP0001727_abnormal_embryo_implantation0.80930383
90MP0001324_abnormal_eye_pigmentation0.80297910
91MP0001845_abnormal_inflammatory_respons0.79417666
92MP0000230_abnormal_systemic_arterial0.78455389
93MP0005310_abnormal_salivary_gland0.78429458
94MP0006072_abnormal_retinal_apoptosis0.78035545
95MP0001542_abnormal_bone_strength0.77600006
96MP0004142_abnormal_muscle_tone0.75453092
97MP0001529_abnormal_vocalization0.75226554
98MP0001986_abnormal_taste_sensitivity0.70968591
99MP0000470_abnormal_stomach_morphology0.70596809
100MP0004043_abnormal_pH_regulation0.69970063

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)5.22848589
2Severe combined immunodeficiency (HP:0004430)4.56178292
3T lymphocytopenia (HP:0005403)4.50382309
4Abnormality of T cell number (HP:0011839)4.03942693
5Elevated erythrocyte sedimentation rate (HP:0003565)3.77396800
6Dynein arm defect of respiratory motile cilia (HP:0012255)3.61082648
7Absent/shortened dynein arms (HP:0200106)3.61082648
8Chronic diarrhea (HP:0002028)3.59214748
9Palpebral edema (HP:0100540)3.51583125
10Combined immunodeficiency (HP:0005387)3.45028904
11Chronic sinusitis (HP:0011109)3.38541987
12Bilateral sensorineural hearing impairment (HP:0008619)3.21181584
13Thyroiditis (HP:0100646)3.17325240
14Autoimmune hemolytic anemia (HP:0001890)3.10257740
15Chronic mucocutaneous candidiasis (HP:0002728)3.08531186
16Recurrent cutaneous fungal infections (HP:0011370)3.08531186
17Thyroid-stimulating hormone excess (HP:0002925)3.01012571
18Prostate neoplasm (HP:0100787)2.96403800
19Enlarged epiphyses (HP:0010580)2.94842705
20Panhypogammaglobulinemia (HP:0003139)2.91273892
21Abnormality of T cells (HP:0002843)2.89379562
22Tubular atrophy (HP:0000092)2.89197649
23Keratoconjunctivitis (HP:0001096)2.88022840
24Metaphyseal dysplasia (HP:0100255)2.87930879
25Abnormal drinking behavior (HP:0030082)2.86267706
26Polydipsia (HP:0001959)2.86267706
27Recurrent bronchitis (HP:0002837)2.77774107
28IgG deficiency (HP:0004315)2.74502966
29Recurrent skin infections (HP:0001581)2.74236439
30Encephalitis (HP:0002383)2.72537310
31Autoimmune thrombocytopenia (HP:0001973)2.69915888
32Nephronophthisis (HP:0000090)2.63593152
33Cerebral hypomyelination (HP:0006808)2.58504458
34Abnormality of the renal cortex (HP:0011035)2.57106326
35Abolished electroretinogram (ERG) (HP:0000550)2.56384617
36Recurrent fungal infections (HP:0002841)2.55784762
37Keratoconjunctivitis sicca (HP:0001097)2.51823823
38Decreased central vision (HP:0007663)2.49084006
39Recurrent bacterial skin infections (HP:0005406)2.48573812
40Retinal atrophy (HP:0001105)2.46091387
41Inflammation of the large intestine (HP:0002037)2.44236518
42Infertility (HP:0000789)2.42448214
43Prominent metopic ridge (HP:0005487)2.39333761
44Abnormality of eosinophils (HP:0001879)2.39031306
45Large eyes (HP:0001090)2.36992440
46Tubulointerstitial fibrosis (HP:0005576)2.36343239
47Abnormality of DNA repair (HP:0003254)2.33093066
48Abnormality of the metopic suture (HP:0005556)2.32567297
49Colitis (HP:0002583)2.31145728
50Abnormality of the prostate (HP:0008775)2.29056871
51Abnormal respiratory motile cilium morphology (HP:0005938)2.27129226
52Abnormal respiratory epithelium morphology (HP:0012253)2.27129226
53Failure to thrive in infancy (HP:0001531)2.23906199
54Hypoplasia of the uterus (HP:0000013)2.21639397
55Gastrointestinal inflammation (HP:0004386)2.20305550
56Hematochezia (HP:0002573)2.16728149
57Hypoproteinemia (HP:0003075)2.16531381
58Stage 5 chronic kidney disease (HP:0003774)2.12430196
59Agammaglobulinemia (HP:0004432)2.09804488
60Abnormality of the renal medulla (HP:0100957)2.08736686
61Polyuria (HP:0000103)2.06338244
62Bronchitis (HP:0012387)2.05655085
63Congenital stationary night blindness (HP:0007642)2.04263357
64Increased circulating renin level (HP:0000848)2.03583332
65CNS hypomyelination (HP:0003429)2.01999964
66Menstrual irregularities (HP:0000858)2.00178554
67Recurrent abscess formation (HP:0002722)1.99166432
68Abnormality of incisor morphology (HP:0011063)1.97898498
69True hermaphroditism (HP:0010459)1.96664936
70Leukocytosis (HP:0001974)1.96121572
71Abnormal albumin level (HP:0012116)1.94897222
72Hypoalbuminemia (HP:0003073)1.94897222
73Recurrent viral infections (HP:0004429)1.94590936
74Pigmentary retinal degeneration (HP:0001146)1.92534043
75Abnormal delayed hypersensitivity skin test (HP:0002963)1.92336945
76B lymphocytopenia (HP:0010976)1.90689940
77Granulocytopenia (HP:0001913)1.90227337
78Medial flaring of the eyebrow (HP:0010747)1.89959950
79Joint swelling (HP:0001386)1.87098715
80Neonatal respiratory distress (HP:0002643)1.86995149
81Abnormal ciliary motility (HP:0012262)1.86846792
82Increased corneal curvature (HP:0100692)1.86020783
83Keratoconus (HP:0000563)1.86020783
84Periorbital edema (HP:0100539)1.84407230
85Oral leukoplakia (HP:0002745)1.84244413
86Tongue fasciculations (HP:0001308)1.82903572
87Facial edema (HP:0000282)1.82279227
88Poor speech (HP:0002465)1.82271351
89Recurrent corneal erosions (HP:0000495)1.81513753
90Dyskinesia (HP:0100660)1.80729549
91Lymphoma (HP:0002665)1.80491712
92Periodontitis (HP:0000704)1.80083669
93Keratitis (HP:0000491)1.79193592
94J-shaped sella turcica (HP:0002680)1.78303953
95Tubulointerstitial abnormality (HP:0001969)1.77754817
96Clubbing of toes (HP:0100760)1.77571596
97Neutropenia (HP:0001875)1.76143468
98Stomatitis (HP:0010280)1.75807563
99Type I diabetes mellitus (HP:0100651)1.74826210
100Chronic otitis media (HP:0000389)1.74015250

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK33.73140848
2KDR3.08478983
3CDK192.77876213
4INSRR2.77416254
5WNK42.73422608
6TESK22.50402494
7CSF1R2.36969629
8SYK2.18929023
9NUAK12.12421406
10BLK2.01935094
11PINK11.93730145
12ZAK1.93434553
13TEC1.83235564
14MAP4K21.83109107
15MAP4K11.78054466
16BRSK21.76105357
17ITK1.73632140
18CAMKK21.69015322
19GRK61.57992347
20FRK1.56028827
21BCKDK1.48942423
22BTK1.47484886
23TXK1.44980133
24TRIM281.43138652
25PIK3CA1.42004384
26IKBKE1.39897953
27JAK11.38670051
28CSK1.37454711
29LYN1.36208310
30MAP3K41.32232958
31FES1.28945985
32LCK1.26384567
33STK391.25579237
34MATK1.21735978
35PRKCQ1.20957371
36MST1R1.19662462
37ERBB31.17980969
38ZAP701.16196953
39VRK11.14891142
40OXSR11.14745628
41PRKCH1.14226173
42EPHA31.12803919
43MAP3K61.09369417
44TNK21.08462885
45DAPK11.08266350
46CCNB10.99982053
47STK160.99740352
48FGR0.97307120
49HCK0.97264446
50KIT0.95243967
51GRK70.89346945
52CDK60.84473628
53DYRK1B0.84092418
54GRK10.83525399
55PAK30.82743954
56IRAK40.82210319
57RPS6KA40.82199122
58VRK20.81416853
59PTK2B0.79464317
60BMPR20.78318901
61PASK0.75472276
62INSR0.74524733
63MST40.73299577
64PRKG20.73159018
65MAP2K70.72747528
66TYK20.72282018
67CAMKK10.71019896
68ADRBK20.70329679
69TESK10.70145343
70PRKCE0.69099478
71MAPKAPK50.68502883
72TIE10.66821521
73DAPK20.65235443
74JAK30.64642389
75MAPKAPK30.64327135
76OBSCN0.63382911
77MKNK10.61747665
78FYN0.60996014
79ACVR1B0.60332291
80STK38L0.57640346
81FGFR30.56670458
82PRKD30.56478734
83EGFR0.50893807
84DYRK1A0.50532077
85CLK10.50171334
86BCR0.47243841
87HIPK20.47057072
88WNK30.46849319
89MAPK70.46474834
90IKBKB0.43164389
91EIF2AK30.43135273
92PLK20.42562116
93IGF1R0.41225092
94CSNK1G30.40159782
95SCYL20.39992889
96PRKACA0.38344759
97PBK0.37745237
98MAPK130.36862453
99ADRBK10.36853753
100WNK10.36438342

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.86646432
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.27202034
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.13118804
4Graft-versus-host disease_Homo sapiens_hsa053323.02778328
5Allograft rejection_Homo sapiens_hsa053302.84837106
6Type I diabetes mellitus_Homo sapiens_hsa049402.68004008
7Autoimmune thyroid disease_Homo sapiens_hsa053202.53274316
8Linoleic acid metabolism_Homo sapiens_hsa005912.46292933
9Salivary secretion_Homo sapiens_hsa049702.34562157
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.31315927
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.28910335
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.11816155
13Primary bile acid biosynthesis_Homo sapiens_hsa001201.99110455
14Antigen processing and presentation_Homo sapiens_hsa046121.90670581
15Taste transduction_Homo sapiens_hsa047421.79144349
16Hematopoietic cell lineage_Homo sapiens_hsa046401.70052196
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.66153833
18Fanconi anemia pathway_Homo sapiens_hsa034601.64401326
19Asthma_Homo sapiens_hsa053101.57716394
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.57071657
21Ether lipid metabolism_Homo sapiens_hsa005651.56747719
22Arachidonic acid metabolism_Homo sapiens_hsa005901.41641635
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41539035
24Propanoate metabolism_Homo sapiens_hsa006401.36597304
25Rheumatoid arthritis_Homo sapiens_hsa053231.33279067
26T cell receptor signaling pathway_Homo sapiens_hsa046601.29551557
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20266599
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.19828723
29Proteasome_Homo sapiens_hsa030501.19384366
30RNA degradation_Homo sapiens_hsa030181.14562573
31Long-term depression_Homo sapiens_hsa047301.09522776
32Selenocompound metabolism_Homo sapiens_hsa004501.09073917
33Measles_Homo sapiens_hsa051621.08488424
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06188582
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01275765
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01247699
37Chemical carcinogenesis_Homo sapiens_hsa052041.00302649
38Serotonergic synapse_Homo sapiens_hsa047260.95654896
39Peroxisome_Homo sapiens_hsa041460.93343299
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91896082
41Sulfur relay system_Homo sapiens_hsa041220.88543853
42Regulation of autophagy_Homo sapiens_hsa041400.88210068
43Phototransduction_Homo sapiens_hsa047440.85801662
44Platelet activation_Homo sapiens_hsa046110.85763497
45Nicotine addiction_Homo sapiens_hsa050330.84946961
46Staphylococcus aureus infection_Homo sapiens_hsa051500.83463292
47Viral myocarditis_Homo sapiens_hsa054160.81393510
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81201043
49Leishmaniasis_Homo sapiens_hsa051400.79452687
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77325287
51Renin secretion_Homo sapiens_hsa049240.76880353
52RNA polymerase_Homo sapiens_hsa030200.76754727
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69673426
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68121728
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67632880
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66257143
57Olfactory transduction_Homo sapiens_hsa047400.65394568
58Homologous recombination_Homo sapiens_hsa034400.64090731
59Oxidative phosphorylation_Homo sapiens_hsa001900.64087818
60Pancreatic secretion_Homo sapiens_hsa049720.62278457
61Cardiac muscle contraction_Homo sapiens_hsa042600.61808279
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61322697
63Ovarian steroidogenesis_Homo sapiens_hsa049130.59033967
64Herpes simplex infection_Homo sapiens_hsa051680.58665672
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58538116
66Tryptophan metabolism_Homo sapiens_hsa003800.57295496
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57253512
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56799655
69Nitrogen metabolism_Homo sapiens_hsa009100.54186428
70Parkinsons disease_Homo sapiens_hsa050120.52955355
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.52810910
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51922934
73Circadian entrainment_Homo sapiens_hsa047130.50201586
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49594051
75Oocyte meiosis_Homo sapiens_hsa041140.49031776
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48519416
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48247893
78Morphine addiction_Homo sapiens_hsa050320.47667021
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46878969
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.45770376
81Dopaminergic synapse_Homo sapiens_hsa047280.45676545
82African trypanosomiasis_Homo sapiens_hsa051430.45500272
83Legionellosis_Homo sapiens_hsa051340.44740339
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44613246
85Salmonella infection_Homo sapiens_hsa051320.43666883
86Protein export_Homo sapiens_hsa030600.42331824
87Pyruvate metabolism_Homo sapiens_hsa006200.41879348
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.38018652
89Caffeine metabolism_Homo sapiens_hsa002320.37430178
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.37017347
91Retinol metabolism_Homo sapiens_hsa008300.35247176
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34433887
93Amphetamine addiction_Homo sapiens_hsa050310.34277086
94Huntingtons disease_Homo sapiens_hsa050160.33440008
95GABAergic synapse_Homo sapiens_hsa047270.33250427
96Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.32960910
97Basal transcription factors_Homo sapiens_hsa030220.31758928
98B cell receptor signaling pathway_Homo sapiens_hsa046620.30780402
99Calcium signaling pathway_Homo sapiens_hsa040200.28201205
100Shigellosis_Homo sapiens_hsa051310.27016899

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