PMS2P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.15714256
2positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.89174792
3mature B cell differentiation involved in immune response (GO:0002313)4.51085345
4regulation of B cell receptor signaling pathway (GO:0050855)4.28408229
5purine nucleotide salvage (GO:0032261)4.15049278
6positive regulation of B cell differentiation (GO:0045579)4.13050418
7mature B cell differentiation (GO:0002335)3.86740299
8dosage compensation (GO:0007549)3.78828144
9B cell receptor signaling pathway (GO:0050853)3.78478133
10positive regulation of granulocyte differentiation (GO:0030854)3.77707359
11Arp2/3 complex-mediated actin nucleation (GO:0034314)3.72338890
12negative thymic T cell selection (GO:0045060)3.62526698
13negative T cell selection (GO:0043383)3.56243290
14purine deoxyribonucleotide catabolic process (GO:0009155)3.49288428
15nucleotide salvage (GO:0043173)3.46884146
16nuclear pore complex assembly (GO:0051292)3.42930526
17T cell migration (GO:0072678)3.34418613
18regulation of gamma-delta T cell differentiation (GO:0045586)3.33295097
19regulation of B cell differentiation (GO:0045577)3.26482438
20positive thymic T cell selection (GO:0045059)3.22852365
21regulation of gamma-delta T cell activation (GO:0046643)3.22322245
22negative regulation of B cell apoptotic process (GO:0002903)3.19017110
23* mismatch repair (GO:0006298)3.14036876
24Peyers patch development (GO:0048541)3.13760160
25mucosal-associated lymphoid tissue development (GO:0048537)3.13760160
26response to peptidoglycan (GO:0032494)3.12627350
27pore complex assembly (GO:0046931)3.08968770
28positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.05711396
29definitive hemopoiesis (GO:0060216)2.99848182
30actin nucleation (GO:0045010)2.97544158
31positive regulation of alpha-beta T cell proliferation (GO:0046641)2.91596722
32T cell selection (GO:0045058)2.89935801
33regulation of alpha-beta T cell proliferation (GO:0046640)2.89817903
34positive T cell selection (GO:0043368)2.89485230
35purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.85730045
36immunoglobulin mediated immune response (GO:0016064)2.81056526
37spliceosomal tri-snRNP complex assembly (GO:0000244)2.78727867
38purine-containing compound salvage (GO:0043101)2.77151289
39neutrophil activation involved in immune response (GO:0002283)2.76240440
40thymic T cell selection (GO:0045061)2.73767616
41negative regulation of cell killing (GO:0031342)2.72128656
42negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.72128656
43regulation of B cell apoptotic process (GO:0002902)2.71984224
443-UTR-mediated mRNA stabilization (GO:0070935)2.70680799
45response to muramyl dipeptide (GO:0032495)2.67378939
46antigen processing and presentation of endogenous antigen (GO:0019883)2.63937935
47hepatocyte apoptotic process (GO:0097284)2.58759286
48snRNA processing (GO:0016180)2.58372627
49regulation of granulocyte differentiation (GO:0030852)2.57983869
50regulation of histone H3-K27 methylation (GO:0061085)2.57962835
51mitochondrial RNA metabolic process (GO:0000959)2.56441391
52chaperone mediated protein folding requiring cofactor (GO:0051085)2.56338005
53purine deoxyribonucleotide metabolic process (GO:0009151)2.55939665
54deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.53986952
55phosphatidylglycerol biosynthetic process (GO:0006655)2.51905541
56snRNA metabolic process (GO:0016073)2.51325563
57nuclear pore organization (GO:0006999)2.50113400
58tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.50008402
59RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.50008402
60antigen receptor-mediated signaling pathway (GO:0050851)2.49256378
61mast cell activation (GO:0045576)2.49023506
62positive regulation of interleukin-2 production (GO:0032743)2.47767736
63regulation of germinal center formation (GO:0002634)2.46602589
64response to UV-C (GO:0010225)2.46322778
65microtubule nucleation (GO:0007020)2.44871236
66negative regulation of erythrocyte differentiation (GO:0045647)2.44298934
67antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.43816617
68B cell mediated immunity (GO:0019724)2.42097322
69regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.42022943
70positive regulation of B cell activation (GO:0050871)2.40256244
71histamine secretion (GO:0001821)2.39700986
72positive regulation of alpha-beta T cell activation (GO:0046635)2.38686392
73ribosome biogenesis (GO:0042254)2.38440976
74positive regulation of T cell cytokine production (GO:0002726)2.37970204
75defense response to protozoan (GO:0042832)2.37895271
76B cell homeostasis (GO:0001782)2.37557508
77antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.37441194
78regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.36197169
79regulation of alpha-beta T cell activation (GO:0046634)2.35077850
80positive regulation of alpha-beta T cell differentiation (GO:0046638)2.34990856
81T cell proliferation (GO:0042098)2.34873175
82embryonic process involved in female pregnancy (GO:0060136)2.33144662
83deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.31359464
84response to protozoan (GO:0001562)2.29230459
85deoxyribonucleotide catabolic process (GO:0009264)2.28856523
86mannosylation (GO:0097502)2.27832001
87antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.27767479
88positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.26987444
89regulation of alpha-beta T cell differentiation (GO:0046637)2.26693710
90deoxyribose phosphate catabolic process (GO:0046386)2.25481351
91adenosine metabolic process (GO:0046085)2.24982279
92positive regulation of T cell differentiation (GO:0045582)2.24571703
93histone mRNA catabolic process (GO:0071044)2.24288836
94B cell activation involved in immune response (GO:0002312)2.23956747
95positive regulation of developmental pigmentation (GO:0048087)2.22253377
96histone H3-K4 methylation (GO:0051568)2.21193538
97positive regulation of B cell proliferation (GO:0030890)2.21064765
98positive regulation of interferon-beta production (GO:0032728)2.20499880
99folic acid-containing compound biosynthetic process (GO:0009396)2.18703031
100response to interleukin-15 (GO:0070672)2.17243636

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.93668478
2E2F7_22180533_ChIP-Seq_HELA_Human3.58096633
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.37203047
4CIITA_25753668_ChIP-Seq_RAJI_Human2.85616561
5SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.77157028
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.64013825
7MYC_22102868_ChIP-Seq_BL_Human2.63992095
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.52933928
9MYB_26560356_Chip-Seq_TH2_Human2.39958724
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.35740679
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.35658326
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.35617615
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.33408340
14VDR_21846776_ChIP-Seq_THP-1_Human2.31484866
15SPI1_23547873_ChIP-Seq_NB4_Human2.28106494
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.25437941
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.24392523
18VDR_23849224_ChIP-Seq_CD4+_Human2.24049386
19FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.13145732
20MYB_26560356_Chip-Seq_TH1_Human2.11494626
21FOXP3_21729870_ChIP-Seq_TREG_Human2.09480320
22ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.08846657
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.03265013
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.02944867
25UTX_26944678_Chip-Seq_JUKART_Human2.01884971
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.95515457
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.94265199
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.92578580
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.88317937
30SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.88208524
31MAF_26560356_Chip-Seq_TH1_Human1.87142298
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.87138360
33SCL_19346495_ChIP-Seq_HPC-7_Human1.86713012
34HOXB4_20404135_ChIP-ChIP_EML_Mouse1.83947722
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.80333705
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.79980686
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.79654833
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.78663974
39GABP_19822575_ChIP-Seq_HepG2_Human1.78374365
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.76628255
41SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74402205
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.72702817
43DCP1A_22483619_ChIP-Seq_HELA_Human1.72032692
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.70008946
45MYB_21317192_ChIP-Seq_ERMYB_Mouse1.69663482
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.66909398
47MAF_26560356_Chip-Seq_TH2_Human1.65665906
48RUNX_20019798_ChIP-Seq_JUKART_Human1.63691060
49ERG_20887958_ChIP-Seq_HPC-7_Mouse1.61934948
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59275028
51GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.58143248
52NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57805303
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56604238
54TFEB_21752829_ChIP-Seq_HELA_Human1.55300518
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.53193911
56MYC_18358816_ChIP-ChIP_MESCs_Mouse1.52967882
57KDM5A_27292631_Chip-Seq_BREAST_Human1.51177473
58RUNX1_22412390_ChIP-Seq_EML_Mouse1.46334712
59MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45594460
60FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.44538833
61XRN2_22483619_ChIP-Seq_HELA_Human1.44169950
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.43865884
63GATA3_27048872_Chip-Seq_THYMUS_Human1.43434198
64MYC_18555785_ChIP-Seq_MESCs_Mouse1.43085509
65CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.42965082
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.41554563
67NELFA_20434984_ChIP-Seq_ESCs_Mouse1.40388563
68VDR_24763502_ChIP-Seq_THP-1_Human1.40355452
69FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.40205566
70CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.38497034
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.35692708
72FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.33433051
73YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33408917
74BRD4_27068464_Chip-Seq_AML-cells_Mouse1.33111202
75SRF_21415370_ChIP-Seq_HL-1_Mouse1.32762706
76SPI1_23127762_ChIP-Seq_K562_Human1.32429739
77BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.32160479
78STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.32123279
79MYC_19030024_ChIP-ChIP_MESCs_Mouse1.31498993
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.28254416
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28025594
82GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26272056
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26105976
84NCOR1_26117541_ChIP-Seq_K562_Human1.24111679
85E2F1_21310950_ChIP-Seq_MCF-7_Human1.23690888
86KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23410953
87HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22446532
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22148719
89ELK1_19687146_ChIP-ChIP_HELA_Human1.19436309
90GATA3_26560356_Chip-Seq_TH2_Human1.19097893
91MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18815495
92PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17328854
93IRF8_27001747_Chip-Seq_BMDM_Mouse1.15503092
94FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15406034
95TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14079813
96KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09875580
97PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09288281
98TCF7_22412390_ChIP-Seq_EML_Mouse1.06552208
99RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04808314
100POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04032429

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.30443695
2MP0003763_abnormal_thymus_physiology3.10888747
3MP0005671_abnormal_response_to2.86892653
4MP0000685_abnormal_immune_system2.78753869
5MP0002396_abnormal_hematopoietic_system2.66971496
6MP0003436_decreased_susceptibility_to2.65380315
7MP0001800_abnormal_humoral_immune2.58878542
8MP0008057_abnormal_DNA_replication2.56369767
9MP0008260_abnormal_autophagy2.54361200
10MP0005000_abnormal_immune_tolerance2.44161071
11MP0002398_abnormal_bone_marrow2.39383492
12MP0008058_abnormal_DNA_repair2.38838889
13MP0002723_abnormal_immune_serum2.16519565
14MP0002420_abnormal_adaptive_immunity2.15271562
15MP0002452_abnormal_antigen_presenting2.14841159
16MP0001819_abnormal_immune_cell2.11909474
17MP0009697_abnormal_copulation2.08867024
18MP0010094_abnormal_chromosome_stability2.06301459
19MP0000465_gastrointestinal_hemorrhage2.03370819
20MP0004808_abnormal_hematopoietic_stem2.01203147
21MP0002722_abnormal_immune_system2.00785765
22MP0000689_abnormal_spleen_morphology2.00600247
23MP0009333_abnormal_splenocyte_physiolog1.99023892
24MP0000703_abnormal_thymus_morphology1.98183640
25MP0000716_abnormal_immune_system1.96531836
26MP0002166_altered_tumor_susceptibility1.90831429
27MP0005464_abnormal_platelet_physiology1.88978016
28MP0009278_abnormal_bone_marrow1.88960161
29MP0003724_increased_susceptibility_to1.84897680
30MP0005025_abnormal_response_to1.80367901
31MP0003111_abnormal_nucleus_morphology1.80043567
32MP0002419_abnormal_innate_immunity1.79803984
33MP0001545_abnormal_hematopoietic_system1.77497616
34MP0005397_hematopoietic_system_phenotyp1.77497616
35MP0002429_abnormal_blood_cell1.76240792
36MP0002148_abnormal_hypersensitivity_rea1.72687801
37MP0005451_abnormal_body_composition1.62211707
38MP0005387_immune_system_phenotype1.60768203
39MP0001790_abnormal_immune_system1.60768203
40MP0005075_abnormal_melanosome_morpholog1.57657111
41MP0002019_abnormal_tumor_incidence1.56693437
42MP0002405_respiratory_system_inflammati1.56581570
43MP0009785_altered_susceptibility_to1.55760386
44MP0003786_premature_aging1.55342275
45MP0003221_abnormal_cardiomyocyte_apopto1.51506426
46MP0003866_abnormal_defecation1.51212608
47MP0003303_peritoneal_inflammation1.49980965
48MP0002006_tumorigenesis1.48453623
49MP0004381_abnormal_hair_follicle1.47859682
50MP0003172_abnormal_lysosome_physiology1.47799655
51MP0002009_preneoplasia1.47607173
52MP0008995_early_reproductive_senescence1.47113920
53MP0005310_abnormal_salivary_gland1.46975023
54MP0003656_abnormal_erythrocyte_physiolo1.45690573
55MP0004947_skin_inflammation1.41848512
56MP0003077_abnormal_cell_cycle1.37917971
57MP0000015_abnormal_ear_pigmentation1.35327604
58MP0009840_abnormal_foam_cell1.29587468
59MP0008877_abnormal_DNA_methylation1.27411988
60MP0001853_heart_inflammation1.26925540
61MP0005058_abnormal_lysosome_morphology1.26082014
62MP0001845_abnormal_inflammatory_respons1.23601694
63MP0010155_abnormal_intestine_physiology1.18954426
64MP0003693_abnormal_embryo_hatching1.18140721
65MP0001764_abnormal_homeostasis1.10288786
66MP0006035_abnormal_mitochondrial_morpho1.09653280
67MP0002332_abnormal_exercise_endurance1.06600078
68MP0001661_extended_life_span1.05928822
69MP0005645_abnormal_hypothalamus_physiol1.04640691
70MP0008469_abnormal_protein_level1.04283309
71MP0000858_altered_metastatic_potential1.01690576
72MP0003191_abnormal_cellular_cholesterol1.00740089
73MP0000313_abnormal_cell_death0.98857979
74MP0000490_abnormal_crypts_of0.96122291
75MP0001873_stomach_inflammation0.95732230
76MP0009764_decreased_sensitivity_to0.94166296
77MP0010307_abnormal_tumor_latency0.92705658
78MP0008007_abnormal_cellular_replicative0.92627027
79MP0004233_abnormal_muscle_weight0.92239084
80MP0009763_increased_sensitivity_to0.92094044
81MP0004957_abnormal_blastocyst_morpholog0.90013397
82MP0005266_abnormal_metabolism0.89502928
83MP0003045_fibrosis0.89337407
84MP0000371_diluted_coat_color0.89001631
85MP0000358_abnormal_cell_content/0.84405716
86MP0009765_abnormal_xenobiotic_induced0.82100249
87MP0008873_increased_physiological_sensi0.79317499
88MP0005621_abnormal_cell_physiology0.77576083
89MP0005384_cellular_phenotype0.73213773
90MP0000372_irregular_coat_pigmentation0.72824315
91MP0005376_homeostasis/metabolism_phenot0.69582646
92MP0003300_gastrointestinal_ulcer0.68042470
93MP0004185_abnormal_adipocyte_glucose0.64474608
94MP0002877_abnormal_melanocyte_morpholog0.63884630
95MP0003448_altered_tumor_morphology0.63255951
96MP0001533_abnormal_skeleton_physiology0.62574611
97MP0002132_abnormal_respiratory_system0.61696483
98MP0003646_muscle_fatigue0.61227969
99MP0000598_abnormal_liver_morphology0.59318958
100MP0008932_abnormal_embryonic_tissue0.57728522

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)5.08601088
2Autoimmune hemolytic anemia (HP:0001890)4.39745626
3Recurrent viral infections (HP:0004429)3.89622926
4Autoimmune thrombocytopenia (HP:0001973)3.67602495
5Granulocytopenia (HP:0001913)3.65848597
6Colitis (HP:0002583)3.61933711
7Recurrent fungal infections (HP:0002841)3.57051928
8Severe combined immunodeficiency (HP:0004430)3.56079719
9B lymphocytopenia (HP:0010976)3.50891926
10IgM deficiency (HP:0002850)3.50604927
11Elevated erythrocyte sedimentation rate (HP:0003565)3.48251223
12Recurrent abscess formation (HP:0002722)3.45894785
13Abnormality of B cell number (HP:0010975)3.32266611
14Meningitis (HP:0001287)3.29207336
15Panhypogammaglobulinemia (HP:0003139)3.28392180
16Increased IgE level (HP:0003212)3.26096553
17Abnormality of T cells (HP:0002843)3.20349102
18Abnormal delayed hypersensitivity skin test (HP:0002963)3.12506081
19Cellulitis (HP:0100658)3.10924983
20Abnormality of T cell physiology (HP:0011840)3.09064582
21Recurrent bacterial skin infections (HP:0005406)3.08764555
22T lymphocytopenia (HP:0005403)3.08266770
23Recurrent cutaneous fungal infections (HP:0011370)2.99484198
24Chronic mucocutaneous candidiasis (HP:0002728)2.99484198
25Eosinophilia (HP:0001880)2.97520556
26Combined immunodeficiency (HP:0005387)2.96424441
27Inflammation of the large intestine (HP:0002037)2.96363499
28Mediastinal lymphadenopathy (HP:0100721)2.94166948
29Spontaneous hematomas (HP:0007420)2.93219996
30Hypertensive crisis (HP:0100735)2.87537696
31Abnormality of eosinophils (HP:0001879)2.86869072
32Gastrointestinal inflammation (HP:0004386)2.84736215
33Aplasia/Hypoplasia of the thymus (HP:0010515)2.80188406
34Abnormality of T cell number (HP:0011839)2.78840981
35Fatigue (HP:0012378)2.78704946
36Chronic diarrhea (HP:0002028)2.71572522
37Pustule (HP:0200039)2.69686557
38Obstructive lung disease (HP:0006536)2.68501058
39Chronic obstructive pulmonary disease (HP:0006510)2.68501058
40J-shaped sella turcica (HP:0002680)2.66703461
41Leukocytosis (HP:0001974)2.64243360
42Acute hepatic failure (HP:0006554)2.57518466
43Eczematoid dermatitis (HP:0000976)2.52697666
44Lymphopenia (HP:0001888)2.50817010
45Abnormality of the fingertips (HP:0001211)2.50207109
46Encephalitis (HP:0002383)2.49964827
47Lymphoma (HP:0002665)2.45587823
48Acute lymphatic leukemia (HP:0006721)2.45389358
49Verrucae (HP:0200043)2.44722608
50Papilloma (HP:0012740)2.44722608
51Myositis (HP:0100614)2.44340992
52Recurrent skin infections (HP:0001581)2.42014285
53Thyroiditis (HP:0100646)2.40073946
54Viral hepatitis (HP:0006562)2.39584753
55Gastrointestinal infarctions (HP:0005244)2.36358915
56Petechiae (HP:0000967)2.31846481
57Chest pain (HP:0100749)2.30423414
58Vasculitis (HP:0002633)2.30407996
59Recurrent bronchitis (HP:0002837)2.28593590
60Abnormality of the thymus (HP:0000777)2.26387381
61Abnormality of cells of the lymphoid lineage (HP:0012140)2.25483404
62Prolonged bleeding time (HP:0003010)2.22756053
63Sepsis (HP:0100806)2.22015699
64Microvesicular hepatic steatosis (HP:0001414)2.21440698
65Amaurosis fugax (HP:0100576)2.21021094
66IgG deficiency (HP:0004315)2.20358691
67Epistaxis (HP:0000421)2.17093917
68Hypergammaglobulinemia (HP:0010702)2.13487920
69Osteomyelitis (HP:0002754)2.13100301
70Neurodegeneration (HP:0002180)2.11970304
71Recurrent sinusitis (HP:0011108)2.10971458
72Seborrheic dermatitis (HP:0001051)2.08715511
73Abnormality of the prostate (HP:0008775)2.07989021
74Gingival bleeding (HP:0000225)2.07280922
75Basal cell carcinoma (HP:0002671)2.00462568
76IgA deficiency (HP:0002720)1.99713433
77Urticaria (HP:0001025)1.97359152
78Poikiloderma (HP:0001029)1.97005640
79Anorexia (HP:0002039)1.96737918
80Premature ovarian failure (HP:0008209)1.96321181
81Progressive external ophthalmoplegia (HP:0000590)1.94821966
82Large eyes (HP:0001090)1.90144471
83Orthostatic hypotension (HP:0001278)1.89082675
84Prostate neoplasm (HP:0100787)1.86913376
85Neutropenia (HP:0001875)1.86697323
86Acute myeloid leukemia (HP:0004808)1.86279935
87Arterial thrombosis (HP:0004420)1.84267277
88Stomatitis (HP:0010280)1.83740674
89Dyschromatopsia (HP:0007641)1.83681834
90Constricted visual fields (HP:0001133)1.80188154
91Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.79899626
92Hypoplasia of the thymus (HP:0000778)1.79023011
93Prominent nose (HP:0000448)1.76379744
94Mesangial abnormality (HP:0001966)1.75758472
95Villous atrophy (HP:0011473)1.75171494
96Abnormality of small intestinal villus morphology (HP:0011472)1.75171494
97Hepatitis (HP:0012115)1.74089735
98Abnormality of macrophages (HP:0004311)1.72923662
99Abnormality of the peritoneum (HP:0002585)1.72389549
100Abnormality of DNA repair (HP:0003254)1.71675361

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.00996485
2MAP4K13.35013519
3TAOK33.03483183
4NUAK12.53076286
5ERN12.51080922
6JAK32.44486707
7MAP2K32.38484757
8MAP3K142.18418678
9CDK121.90177336
10GRK61.81897075
11TBK11.79121515
12KIT1.77807705
13TXK1.76181398
14SCYL21.75103177
15BTK1.73973893
16BMPR21.71532452
17EIF2AK31.70606533
18SIK21.64339215
19IRAK41.62584317
20NEK11.62463307
21SYK1.59583297
22RIPK41.58793648
23BRD41.56578455
24SMG11.54301512
25BLK1.52743797
26FLT31.51503790
27IKBKB1.41842835
28IKBKE1.39049893
29KDR1.36115209
30CAMKK21.33533569
31FES1.32846634
32MAPK111.30637509
33IRAK31.30042468
34RPS6KB21.27651313
35VRK21.23453462
36TESK21.19188730
37TEC1.16238090
38BCKDK1.15297061
39HCK1.13287784
40DYRK31.11434452
41MAPKAPK31.11422704
42LCK1.08329461
43PBK1.07600219
44SRPK11.06394332
45MAPKAPK51.05586420
46MARK31.02371748
47LYN0.98868840
48RPS6KA40.96415496
49EPHA30.96403492
50LATS10.95841247
51ITK0.92470423
52ATR0.90533432
53CSF1R0.90356210
54RPS6KA50.87046797
55PIM20.86051710
56MAP3K60.85961785
57RAF10.85071945
58PKN20.83572356
59CDK90.82036841
60NME20.80912655
61IRAK20.79416319
62PIM10.78161459
63SIK30.77483452
64TYK20.76598957
65PIK3CG0.72442007
66IRAK10.72251483
67CSNK1A1L0.72104479
68NEK20.70739865
69DAPK10.70164667
70JAK20.69997416
71FGR0.69372503
72TRPM70.64198977
73ZAP700.64098517
74CCNB10.63994026
75MAP3K30.63072533
76CSNK1G30.61075766
77MAP3K130.60550621
78CDK40.59691440
79CLK10.59157229
80JAK10.57798545
81MAP3K110.57539673
82PRPF4B0.56044948
83STK40.55707207
84MAP3K10.54940911
85CSK0.54325101
86MAP3K40.52673678
87TNK20.52325919
88MATK0.52276681
89MAP3K50.51050629
90CHUK0.50481458
91EEF2K0.50141276
92CDK80.45939680
93CDK60.44863085
94VRK10.42961114
95CDK70.42627655
96STK100.40271668
97MAPK120.39850321
98MAP2K40.39660052
99CHEK10.38927760
100PRKCQ0.37813616

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.52821032
2Allograft rejection_Homo sapiens_hsa053302.28906639
3Asthma_Homo sapiens_hsa053102.08852061
4Graft-versus-host disease_Homo sapiens_hsa053322.08273906
5RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.05370693
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.04409175
7Leishmaniasis_Homo sapiens_hsa051402.02714716
8Autoimmune thyroid disease_Homo sapiens_hsa053202.02581787
9Herpes simplex infection_Homo sapiens_hsa051681.93598436
10Measles_Homo sapiens_hsa051621.88906399
11Other glycan degradation_Homo sapiens_hsa005111.78481763
12Non-homologous end-joining_Homo sapiens_hsa034501.77830183
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.75408185
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.73060807
15Type I diabetes mellitus_Homo sapiens_hsa049401.72565376
16Spliceosome_Homo sapiens_hsa030401.72183792
17Base excision repair_Homo sapiens_hsa034101.63421877
18B cell receptor signaling pathway_Homo sapiens_hsa046621.59260996
19DNA replication_Homo sapiens_hsa030301.56819892
20Mismatch repair_Homo sapiens_hsa034301.55393293
21Fanconi anemia pathway_Homo sapiens_hsa034601.50176654
22Acute myeloid leukemia_Homo sapiens_hsa052211.50111657
23Epstein-Barr virus infection_Homo sapiens_hsa051691.49158196
24Influenza A_Homo sapiens_hsa051641.48645819
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.48408729
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.46995807
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44649437
28Antigen processing and presentation_Homo sapiens_hsa046121.43668815
29Systemic lupus erythematosus_Homo sapiens_hsa053221.39658426
30Legionellosis_Homo sapiens_hsa051341.35650924
31mRNA surveillance pathway_Homo sapiens_hsa030151.33223158
32Viral myocarditis_Homo sapiens_hsa054161.32076799
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.29109146
34Osteoclast differentiation_Homo sapiens_hsa043801.28390167
35Viral carcinogenesis_Homo sapiens_hsa052031.27434451
36Homologous recombination_Homo sapiens_hsa034401.27305477
37Regulation of autophagy_Homo sapiens_hsa041401.26127080
38One carbon pool by folate_Homo sapiens_hsa006701.26090035
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.25816187
40Shigellosis_Homo sapiens_hsa051311.25226142
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.24967789
42Hematopoietic cell lineage_Homo sapiens_hsa046401.24295883
43Apoptosis_Homo sapiens_hsa042101.23744837
44Proteasome_Homo sapiens_hsa030501.21447059
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.21173906
46Tuberculosis_Homo sapiens_hsa051521.19363149
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.19196093
48T cell receptor signaling pathway_Homo sapiens_hsa046601.18651138
49Non-small cell lung cancer_Homo sapiens_hsa052231.18571365
50Nucleotide excision repair_Homo sapiens_hsa034201.17923645
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17048351
52Hepatitis B_Homo sapiens_hsa051611.16125604
53Toxoplasmosis_Homo sapiens_hsa051451.16035184
54Toll-like receptor signaling pathway_Homo sapiens_hsa046201.15203178
55RNA transport_Homo sapiens_hsa030131.12330559
56RNA polymerase_Homo sapiens_hsa030201.10425197
57Transcriptional misregulation in cancer_Homo sapiens_hsa052021.08753768
58Pyrimidine metabolism_Homo sapiens_hsa002401.08660854
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.04294982
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04213445
61RNA degradation_Homo sapiens_hsa030181.03045924
62p53 signaling pathway_Homo sapiens_hsa041150.92393989
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91008831
64Pancreatic cancer_Homo sapiens_hsa052120.89386812
65Platelet activation_Homo sapiens_hsa046110.81821503
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80780822
67mTOR signaling pathway_Homo sapiens_hsa041500.79216816
68HTLV-I infection_Homo sapiens_hsa051660.77487352
69N-Glycan biosynthesis_Homo sapiens_hsa005100.76160711
70Cell cycle_Homo sapiens_hsa041100.75432535
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75257889
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.70108125
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69398743
74TNF signaling pathway_Homo sapiens_hsa046680.68738808
75Rheumatoid arthritis_Homo sapiens_hsa053230.68693123
76Chronic myeloid leukemia_Homo sapiens_hsa052200.65238597
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64114708
78Alcoholism_Homo sapiens_hsa050340.62173980
79Salmonella infection_Homo sapiens_hsa051320.62011571
80Basal transcription factors_Homo sapiens_hsa030220.61820077
81Inositol phosphate metabolism_Homo sapiens_hsa005620.60158806
82Purine metabolism_Homo sapiens_hsa002300.58852138
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57553913
84Staphylococcus aureus infection_Homo sapiens_hsa051500.57363082
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56817461
86Prolactin signaling pathway_Homo sapiens_hsa049170.56323980
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56191075
88Hepatitis C_Homo sapiens_hsa051600.55562785
89Sulfur relay system_Homo sapiens_hsa041220.55017332
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46263380
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.41533481
92Choline metabolism in cancer_Homo sapiens_hsa052310.39255541
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39140703
94Thyroid cancer_Homo sapiens_hsa052160.37831703
95Phagosome_Homo sapiens_hsa041450.36462693
96Pertussis_Homo sapiens_hsa051330.34778569
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34520042
98Lysosome_Homo sapiens_hsa041420.33645016
99Chemokine signaling pathway_Homo sapiens_hsa040620.33276950
100Colorectal cancer_Homo sapiens_hsa052100.30080200

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