ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein complex biogenesis (GO:0070271)	5.86949533
2	mitochondrial respiratory chain complex assembly (GO:0033108)	5.33413978
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.24906500
4	NADH dehydrogenase complex assembly (GO:0010257)	5.12960696
5	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	5.12960696
6	mitochondrial respiratory chain complex I assembly (GO:0032981)	5.12960696
7	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.80297401
8	protein-cofactor linkage (GO:0018065)	4.60374790
9	ATP synthesis coupled proton transport (GO:0015986)	4.51576152
10	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.51576152
11	respiratory electron transport chain (GO:0022904)	4.22810384
12	electron transport chain (GO:0022900)	4.16998650
13	protein polyglutamylation (GO:0018095)	4.14671450
14	regulation of mitochondrial translation (GO:0070129)	4.05597699
15	cytochrome complex assembly (GO:0017004)	3.96749723
16	platelet dense granule organization (GO:0060155)	3.82135093
17	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.69040877
18	protein deneddylation (GO:0000338)	3.67539921
19	water-soluble vitamin biosynthetic process (GO:0042364)	3.62320506
20	proteasome assembly (GO:0043248)	3.57755740
21	cullin deneddylation (GO:0010388)	3.56658400
22	mannosylation (GO:0097502)	3.55132078
23	respiratory chain complex IV assembly (GO:0008535)	3.49763136
24	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.42437593
25	sequestering of actin monomers (GO:0042989)	3.41922374
26	mismatch repair (GO:0006298)	3.36518220
27	nonmotile primary cilium assembly (GO:0035058)	3.36400667
28	protein neddylation (GO:0045116)	3.33350759
29	termination of RNA polymerase III transcription (GO:0006386)	3.31076873
30	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.31076873
31	regulation of cilium movement (GO:0003352)	3.26809774
32	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.22030569
33	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.21751778
34	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.21751778
35	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.19007034
36	response to pheromone (GO:0019236)	3.14755469
37	hydrogen ion transmembrane transport (GO:1902600)	3.14278046
38	regulation of glucokinase activity (GO:0033131)	3.13059236
39	regulation of hexokinase activity (GO:1903299)	3.13059236
40	base-excision repair, AP site formation (GO:0006285)	3.11367483
41	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.10396716
42	regulation of mitotic spindle checkpoint (GO:1903504)	3.08997445
43	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.08997445
44	proton transport (GO:0015992)	3.01761158
45	pseudouridine synthesis (GO:0001522)	2.98603361
46	axoneme assembly (GO:0035082)	2.97544372
47	metallo-sulfur cluster assembly (GO:0031163)	2.97194108
48	iron-sulfur cluster assembly (GO:0016226)	2.97194108
49	fucose catabolic process (GO:0019317)	2.95867059
50	L-fucose metabolic process (GO:0042354)	2.95867059
51	L-fucose catabolic process (GO:0042355)	2.95867059
52	hydrogen transport (GO:0006818)	2.95394904
53	retinal cone cell development (GO:0046549)	2.91733039
54	rRNA modification (GO:0000154)	2.91559607
55	chaperone-mediated protein transport (GO:0072321)	2.91548699
56	adenosine metabolic process (GO:0046085)	2.88983543
57	pyrimidine nucleotide catabolic process (GO:0006244)	2.87740388
58	inositol phosphate catabolic process (GO:0071545)	2.84244490
59	ubiquinone biosynthetic process (GO:0006744)	2.82704870
60	DNA integration (GO:0015074)	2.82571450
61	GPI anchor metabolic process (GO:0006505)	2.82149766
62	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.81328560
63	preassembly of GPI anchor in ER membrane (GO:0016254)	2.80105755
64	centriole replication (GO:0007099)	2.78535041
65	negative regulation of heart rate (GO:0010459)	2.76904457
66	C-terminal protein lipidation (GO:0006501)	2.73204791
67	inner mitochondrial membrane organization (GO:0007007)	2.73072066
68	cilium morphogenesis (GO:0060271)	2.72777587
69	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.71331941
70	inositol phosphate dephosphorylation (GO:0046855)	2.71331941
71	negative regulation of membrane potential (GO:0045837)	2.70297583
72	intracellular protein transmembrane import (GO:0044743)	2.68367812
73	7-methylguanosine mRNA capping (GO:0006370)	2.67735770
74	epithelial cilium movement (GO:0003351)	2.67486350
75	detection of light stimulus involved in sensory perception (GO:0050962)	2.67112357
76	detection of light stimulus involved in visual perception (GO:0050908)	2.67112357
77	L-methionine salvage (GO:0071267)	2.67039251
78	L-methionine biosynthetic process (GO:0071265)	2.67039251
79	amino acid salvage (GO:0043102)	2.67039251
80	ATP biosynthetic process (GO:0006754)	2.63787094
81	7-methylguanosine RNA capping (GO:0009452)	2.60692508
82	RNA capping (GO:0036260)	2.60692508
83	ubiquinone metabolic process (GO:0006743)	2.58146714
84	gamma-aminobutyric acid transport (GO:0015812)	2.58046524
85	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.57049250
86	ATP hydrolysis coupled proton transport (GO:0015991)	2.55124120
87	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.55124120
88	S-adenosylmethionine metabolic process (GO:0046500)	2.54842461
89	protein localization to cilium (GO:0061512)	2.54421616
90	C-terminal protein amino acid modification (GO:0018410)	2.53870932
91	DNA double-strand break processing (GO:0000729)	2.53709771
92	tRNA processing (GO:0008033)	2.52109891
93	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.50610126
94	DNA deamination (GO:0045006)	2.50258929
95	cellular component biogenesis (GO:0044085)	2.50042650
96	spliceosomal snRNP assembly (GO:0000387)	2.49169709
97	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.49079515
98	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.49079515
99	GPI anchor biosynthetic process (GO:0006506)	2.48960934
100	GMP metabolic process (GO:0046037)	2.48223473

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.32796190
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.73552063
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.56329813
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.36805128
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.32106890
6	ZNF274_21170338_ChIP-Seq_K562_Hela	3.26518561
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.60239988
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.58180693
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.57170097
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.55182040
11	VDR_22108803_ChIP-Seq_LS180_Human	2.52898943
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.47813772
13	GBX2_23144817_ChIP-Seq_PC3_Human	2.37132570
14	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.33654490
15	ELK1_19687146_ChIP-ChIP_HELA_Human	2.29029022
16	IGF1R_20145208_ChIP-Seq_DFB_Human	2.28266829
17	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.28041189
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.26249394
19	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.09360959
20	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.08233867
21	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.96881689
22	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.94920802
23	FUS_26573619_Chip-Seq_HEK293_Human	1.92651157
24	FOXP3_21729870_ChIP-Seq_TREG_Human	1.92332709
25	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.90847520
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.86893359
27	EWS_26573619_Chip-Seq_HEK293_Human	1.85858032
28	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.83563331
29	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.78844056
30	TAF15_26573619_Chip-Seq_HEK293_Human	1.71787498
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.69601151
32	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.69250641
33	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.61525610
34	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.60466539
35	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.60062784
36	EZH2_22144423_ChIP-Seq_EOC_Human	1.56934947
37	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.55643756
38	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.51664621
39	P300_19829295_ChIP-Seq_ESCs_Human	1.50732434
40	ER_23166858_ChIP-Seq_MCF-7_Human	1.46540565
41	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.45959834
42	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.45300364
43	TP53_22573176_ChIP-Seq_HFKS_Human	1.44987305
44	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.44233482
45	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.43687949
46	DCP1A_22483619_ChIP-Seq_HELA_Human	1.35474132
47	TTF2_22483619_ChIP-Seq_HELA_Human	1.33903424
48	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.32409992
49	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.30684444
50	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.30039402
51	GABP_19822575_ChIP-Seq_HepG2_Human	1.26714925
52	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.26345128
53	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.24022160
54	IRF1_19129219_ChIP-ChIP_H3396_Human	1.23205051
55	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.22028628
56	CBP_20019798_ChIP-Seq_JUKART_Human	1.21250774
57	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.21250774
58	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.20372928
59	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.20372928
60	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.19300890
61	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.17144666
62	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.12185964
63	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.08723785
64	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.08602866
65	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.07941874
66	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.07426787
67	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.05985979
68	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.05226950
69	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.03913042
70	BCAT_22108803_ChIP-Seq_LS180_Human	1.03478383
71	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.02759976
72	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.01192109
73	NCOR_22424771_ChIP-Seq_293T_Human	0.99740174
74	SOX2_19829295_ChIP-Seq_ESCs_Human	0.99722101
75	NANOG_19829295_ChIP-Seq_ESCs_Human	0.99722101
76	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.98659797
77	AR_20517297_ChIP-Seq_VCAP_Human	0.98441053
78	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.97970765
79	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.97886515
80	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.96734238
81	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.95737339
82	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.95547568
83	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.93537005
84	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.93524418
85	AR_25329375_ChIP-Seq_VCAP_Human	0.91037386
86	RNF2_27304074_Chip-Seq_NSC_Mouse	0.90965964
87	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.90698609
88	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.89102666
89	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.88925998
90	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.88221368
91	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.87759883
92	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.87422141
93	SMAD4_21799915_ChIP-Seq_A2780_Human	0.86785446
94	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.86115193
95	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.86069011
96	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.85657057
97	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.85301790
98	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.85091715
99	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.84631024
100	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.82645297

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.03823291
2	MP0008877_abnormal_DNA_methylation	2.94962719
3	MP0006072_abnormal_retinal_apoptosis	2.62116350
4	MP0002102_abnormal_ear_morphology	2.46907112
5	MP0002736_abnormal_nociception_after	2.44996495
6	MP0001529_abnormal_vocalization	2.41858116
7	MP0001984_abnormal_olfaction	2.40767081
8	MP0002837_dystrophic_cardiac_calcinosis	2.35916280
9	MP0001968_abnormal_touch/_nociception	2.31578459
10	MP0002938_white_spotting	2.30670107
11	MP0005551_abnormal_eye_electrophysiolog	2.26405133
12	MP0003122_maternal_imprinting	2.25396244
13	MP0008058_abnormal_DNA_repair	2.23779788
14	MP0004142_abnormal_muscle_tone	2.18789351
15	MP0005075_abnormal_melanosome_morpholog	2.06453324
16	MP0009046_muscle_twitch	2.06428851
17	MP0002234_abnormal_pharynx_morphology	2.04785920
18	MP0000569_abnormal_digit_pigmentation	2.02050651
19	MP0005084_abnormal_gallbladder_morpholo	1.96747792
20	MP0004147_increased_porphyrin_level	1.94793997
21	MP0003195_calcinosis	1.94742780
22	MP0003011_delayed_dark_adaptation	1.89175333
23	MP0005253_abnormal_eye_physiology	1.85940322
24	MP0003787_abnormal_imprinting	1.79296750
25	MP0001905_abnormal_dopamine_level	1.71917246
26	MP0003136_yellow_coat_color	1.69303795
27	MP0002653_abnormal_ependyma_morphology	1.67506214
28	MP0003121_genomic_imprinting	1.66147928
29	MP0002272_abnormal_nervous_system	1.65860499
30	MP0003718_maternal_effect	1.64624545
31	MP0003646_muscle_fatigue	1.62395790
32	MP0001486_abnormal_startle_reflex	1.61100209
33	MP0005645_abnormal_hypothalamus_physiol	1.59598463
34	MP0008872_abnormal_physiological_respon	1.55942820
35	MP0008995_early_reproductive_senescence	1.54129482
36	MP0009745_abnormal_behavioral_response	1.51210833
37	MP0008875_abnormal_xenobiotic_pharmacok	1.50978533
38	MP0006276_abnormal_autonomic_nervous	1.48662953
39	MP0008789_abnormal_olfactory_epithelium	1.44384287
40	MP0005646_abnormal_pituitary_gland	1.44120068
41	MP0001764_abnormal_homeostasis	1.43395891
42	MP0001986_abnormal_taste_sensitivity	1.40867363
43	MP0010386_abnormal_urinary_bladder	1.36845598
44	MP0002735_abnormal_chemical_nociception	1.34840597
45	MP0004133_heterotaxia	1.34732399
46	MP0003786_premature_aging	1.34200102
47	MP0004885_abnormal_endolymph	1.31708324
48	MP0002638_abnormal_pupillary_reflex	1.31082219
49	MP0004742_abnormal_vestibular_system	1.28627230
50	MP0006035_abnormal_mitochondrial_morpho	1.28269839
51	MP0006292_abnormal_olfactory_placode	1.27263473
52	MP0002064_seizures	1.23453453
53	MP0000372_irregular_coat_pigmentation	1.20286045
54	MP0005410_abnormal_fertilization	1.19218707
55	MP0009379_abnormal_foot_pigmentation	1.19116619
56	MP0002557_abnormal_social/conspecific_i	1.17593742
57	MP0002751_abnormal_autonomic_nervous	1.15740772
58	MP0005499_abnormal_olfactory_system	1.14751810
59	MP0005394_taste/olfaction_phenotype	1.14751810
60	MP0002822_catalepsy	1.13687984
61	MP0006036_abnormal_mitochondrial_physio	1.13279335
62	MP0005174_abnormal_tail_pigmentation	1.12878760
63	MP0002572_abnormal_emotion/affect_behav	1.09721481
64	MP0002095_abnormal_skin_pigmentation	1.09156335
65	MP0002928_abnormal_bile_duct	1.08960519
66	MP0002067_abnormal_sensory_capabilities	1.06283199
67	MP0003186_abnormal_redox_activity	1.01570860
68	MP0002733_abnormal_thermal_nociception	1.01090413
69	MP0001970_abnormal_pain_threshold	1.01060554
70	MP0000026_abnormal_inner_ear	1.00129152
71	MP0004043_abnormal_pH_regulation	0.99205521
72	MP0001929_abnormal_gametogenesis	0.97371816
73	MP0000631_abnormal_neuroendocrine_gland	0.97091568
74	MP0001501_abnormal_sleep_pattern	0.92565595
75	MP0002210_abnormal_sex_determination	0.91609634
76	MP0005332_abnormal_amino_acid	0.89742163
77	MP0002160_abnormal_reproductive_system	0.89115788
78	MP0005389_reproductive_system_phenotype	0.88767382
79	MP0003698_abnormal_male_reproductive	0.87494719
80	MP0002876_abnormal_thyroid_physiology	0.87454513
81	MP0001963_abnormal_hearing_physiology	0.86667418
82	MP0003635_abnormal_synaptic_transmissio	0.86139536
83	MP0002752_abnormal_somatic_nervous	0.85981979
84	MP0001485_abnormal_pinna_reflex	0.84944248
85	MP0002734_abnormal_mechanical_nocicepti	0.82564801
86	MP0009697_abnormal_copulation	0.81887319
87	MP0005423_abnormal_somatic_nervous	0.81732140
88	MP0000653_abnormal_sex_gland	0.80485445
89	MP0010094_abnormal_chromosome_stability	0.79770583
90	MP0005171_absent_coat_pigmentation	0.79267711
91	MP0005195_abnormal_posterior_eye	0.78267123
92	MP0000778_abnormal_nervous_system	0.78234051
93	MP0002184_abnormal_innervation	0.78109714
94	MP0004924_abnormal_behavior	0.77784883
95	MP0005386_behavior/neurological_phenoty	0.77784883
96	MP0002163_abnormal_gland_morphology	0.75940090
97	MP0003693_abnormal_embryo_hatching	0.75889513
98	MP0001145_abnormal_male_reproductive	0.75789662
99	MP0000358_abnormal_cell_content/	0.75534459
100	MP0002277_abnormal_respiratory_mucosa	0.75291396

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.10344889
2	Abnormal mitochondria in muscle tissue (HP:0008316)	4.83166300
3	Mitochondrial inheritance (HP:0001427)	4.60000402
4	Progressive macrocephaly (HP:0004481)	4.48286503
5	Acute encephalopathy (HP:0006846)	4.32265415
6	Hepatocellular necrosis (HP:0001404)	4.20426165
7	Increased CSF lactate (HP:0002490)	4.04998318
8	Hepatic necrosis (HP:0002605)	4.01011770
9	3-Methylglutaconic aciduria (HP:0003535)	3.66424954
10	Increased hepatocellular lipid droplets (HP:0006565)	3.59551158
11	Medial flaring of the eyebrow (HP:0010747)	3.37638066
12	Abnormality of midbrain morphology (HP:0002418)	3.36885173
13	Molar tooth sign on MRI (HP:0002419)	3.36885173
14	Cerebral edema (HP:0002181)	3.32519355
15	Pancreatic cysts (HP:0001737)	3.30856322
16	Lipid accumulation in hepatocytes (HP:0006561)	3.28891713
17	True hermaphroditism (HP:0010459)	3.05778436
18	Pancreatic fibrosis (HP:0100732)	3.00045906
19	Renal Fanconi syndrome (HP:0001994)	2.98876399
20	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.98867765
21	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.98867765
22	Nephronophthisis (HP:0000090)	2.98391206
23	Methylmalonic acidemia (HP:0002912)	2.97443015
24	Optic disc pallor (HP:0000543)	2.97104452
25	Gait imbalance (HP:0002141)	2.94448215
26	Congenital primary aphakia (HP:0007707)	2.91171019
27	Methylmalonic aciduria (HP:0012120)	2.75208639
28	Congenital, generalized hypertrichosis (HP:0004540)	2.72152753
29	Increased intramyocellular lipid droplets (HP:0012240)	2.70560610
30	Lactic acidosis (HP:0003128)	2.70214109
31	Abnormal number of erythroid precursors (HP:0012131)	2.69068598
32	Nephrogenic diabetes insipidus (HP:0009806)	2.64458974
33	Congenital stationary night blindness (HP:0007642)	2.60446258
34	Increased serum lactate (HP:0002151)	2.58568775
35	Abnormality of the labia minora (HP:0012880)	2.53096315
36	Colon cancer (HP:0003003)	2.49452753
37	Respiratory failure (HP:0002878)	2.47830770
38	Hypothermia (HP:0002045)	2.47617895
39	Cutaneous melanoma (HP:0012056)	2.41751081
40	Abnormality of the renal medulla (HP:0100957)	2.38379189
41	Hyperglycinemia (HP:0002154)	2.35977040
42	Type I transferrin isoform profile (HP:0003642)	2.31443500
43	Exertional dyspnea (HP:0002875)	2.28889205
44	Exercise intolerance (HP:0003546)	2.28423113
45	Generalized aminoaciduria (HP:0002909)	2.25792135
46	Abnormality of the renal cortex (HP:0011035)	2.25109689
47	Type II lissencephaly (HP:0007260)	2.22646842
48	Retinal dysplasia (HP:0007973)	2.21859555
49	Genital tract atresia (HP:0001827)	2.20952127
50	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.19165560
51	Vaginal atresia (HP:0000148)	2.18587937
52	Glycosuria (HP:0003076)	2.16539093
53	Abnormality of urine glucose concentration (HP:0011016)	2.16539093
54	Increased muscle lipid content (HP:0009058)	2.15819451
55	Sclerocornea (HP:0000647)	2.15735333
56	Abnormality of cells of the erythroid lineage (HP:0012130)	2.15191200
57	Renal cortical cysts (HP:0000803)	2.11114804
58	Abnormal protein glycosylation (HP:0012346)	2.11048557
59	Abnormal glycosylation (HP:0012345)	2.11048557
60	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.11048557
61	Abnormal protein N-linked glycosylation (HP:0012347)	2.11048557
62	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.08331926
63	Dicarboxylic aciduria (HP:0003215)	2.08331926
64	Polyphagia (HP:0002591)	2.08299009
65	Lethargy (HP:0001254)	2.07949967
66	Aplasia/hypoplasia of the uterus (HP:0008684)	2.07121294
67	Attenuation of retinal blood vessels (HP:0007843)	2.05046603
68	Leukodystrophy (HP:0002415)	2.03604092
69	Focal motor seizures (HP:0011153)	1.98034329
70	Dialeptic seizures (HP:0011146)	1.96411168
71	Abolished electroretinogram (ERG) (HP:0000550)	1.95522584
72	Hypoplasia of the fovea (HP:0007750)	1.94415714
73	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.94415714
74	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.92274932
75	Emotional lability (HP:0000712)	1.91414157
76	Specific learning disability (HP:0001328)	1.91127284
77	Abnormality of the fovea (HP:0000493)	1.89999813
78	Aplastic anemia (HP:0001915)	1.87301336
79	Chronic hepatic failure (HP:0100626)	1.86485943
80	Hemiparesis (HP:0001269)	1.86436769
81	Inability to walk (HP:0002540)	1.84617719
82	Progressive inability to walk (HP:0002505)	1.82911081
83	Ketosis (HP:0001946)	1.81497227
84	Abnormal biliary tract physiology (HP:0012439)	1.78002793
85	Bile duct proliferation (HP:0001408)	1.78002793
86	Progressive microcephaly (HP:0000253)	1.77834258
87	CNS demyelination (HP:0007305)	1.76617662
88	Cystic liver disease (HP:0006706)	1.76169149
89	Occipital encephalocele (HP:0002085)	1.75388699
90	Poor coordination (HP:0002370)	1.75075516
91	Abnormality of vitamin B metabolism (HP:0004340)	1.74002470
92	Absent thumb (HP:0009777)	1.71628732
93	Abnormal rod and cone electroretinograms (HP:0008323)	1.71602377
94	Limb dystonia (HP:0002451)	1.70094220
95	Pancytopenia (HP:0001876)	1.70090911
96	Ependymoma (HP:0002888)	1.68915662
97	Postaxial hand polydactyly (HP:0001162)	1.68619642
98	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.68248023
99	Pendular nystagmus (HP:0012043)	1.67543933
100	Abnormality of macular pigmentation (HP:0008002)	1.67456186

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.85113158
2	VRK2	4.07137487
3	FRK	3.16134181
4	TAOK3	2.69869856
5	NUAK1	2.67824085
6	BCKDK	2.56938507
7	ZAK	2.41997741
8	VRK1	2.36839141
9	WNK3	2.35377165
10	MAP3K4	2.11214578
11	STK16	2.00572925
12	ADRBK2	1.88772420
13	GRK1	1.79472591
14	DYRK2	1.65586833
15	TLK1	1.64186701
16	BUB1	1.59855087
17	TNIK	1.56739182
18	TRIM28	1.53738976
19	MAPK13	1.48852220
20	MAP2K7	1.46048732
21	MST4	1.45505351
22	CSNK1G3	1.42118009
23	PINK1	1.39784546
24	CSNK1G2	1.37711529
25	BMPR1B	1.33155280
26	MARK1	1.33037240
27	PLK4	1.32681047
28	TXK	1.32622488
29	INSRR	1.31726724
30	CDC7	1.24991223
31	PAK3	1.24378326
32	NME1	1.22002533
33	PLK3	1.20684386
34	CASK	1.18075370
35	CSNK1G1	1.11820043
36	FLT3	1.05982857
37	CSNK1A1L	1.04784530
38	CCNB1	1.04258172
39	NEK1	1.03195185
40	ACVR1B	0.98488569
41	BRSK2	0.93993681
42	MAPKAPK5	0.89925611
43	MUSK	0.88837431
44	MAP3K12	0.88811284
45	RPS6KA5	0.88595771
46	BCR	0.86816551
47	PLK2	0.86290761
48	SRPK1	0.85010639
49	CAMKK2	0.83606140
50	ADRBK1	0.76574072
51	TIE1	0.76498802
52	GRK7	0.76370280
53	PRKCG	0.76352430
54	PRKCE	0.74489323
55	CDK8	0.74424986
56	TESK2	0.73866541
57	EIF2AK3	0.70000452
58	IKBKB	0.68445532
59	PLK1	0.68393932
60	EPHA3	0.67076191
61	MAP2K2	0.65878504
62	GRK5	0.65414321
63	EIF2AK1	0.63801055
64	ERBB3	0.63701703
65	PHKG2	0.62254825
66	PHKG1	0.62254825
67	RPS6KA4	0.61785683
68	DYRK3	0.61022457
69	PASK	0.60859768
70	CDK3	0.55590949
71	PKN1	0.53573028
72	FGFR2	0.51031346
73	WEE1	0.51006305
74	TSSK6	0.50734616
75	WNK4	0.50655732
76	TAF1	0.50280119
77	ATR	0.48501931
78	CSNK1A1	0.47545614
79	MKNK1	0.46353789
80	PDK2	0.45075434
81	MINK1	0.45028375
82	PRKCI	0.43528670
83	GRK6	0.43311153
84	CSNK2A1	0.42825163
85	TEC	0.42463689
86	CSNK2A2	0.41791256
87	OXSR1	0.41773136
88	STK38L	0.41337268
89	MAPK15	0.40404276
90	PTK2B	0.39542205
91	NLK	0.39442446
92	CHEK2	0.39234432
93	AURKB	0.38911996
94	TGFBR1	0.37803555
95	EPHA4	0.37269567
96	LIMK1	0.36930021
97	DAPK1	0.36469587
98	PNCK	0.35899543
99	PRKACA	0.35276978
100	PRKACB	0.34739109

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.35830519
2	Protein export_Homo sapiens_hsa03060	3.59971576
3	Parkinsons disease_Homo sapiens_hsa05012	3.48450125
4	RNA polymerase_Homo sapiens_hsa03020	3.09883377
5	Proteasome_Homo sapiens_hsa03050	2.88350448
6	Huntingtons disease_Homo sapiens_hsa05016	2.49538187
7	Ribosome_Homo sapiens_hsa03010	2.47042230
8	Alzheimers disease_Homo sapiens_hsa05010	2.33629164
9	Mismatch repair_Homo sapiens_hsa03430	2.21587491
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.19913012
11	Homologous recombination_Homo sapiens_hsa03440	2.12494790
12	Fanconi anemia pathway_Homo sapiens_hsa03460	2.05234075
13	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.98958641
14	Phototransduction_Homo sapiens_hsa04744	1.94884742
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.92478027
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.85040768
17	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.78197126
18	Fatty acid elongation_Homo sapiens_hsa00062	1.77307641
19	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.76257581
20	Butanoate metabolism_Homo sapiens_hsa00650	1.66520484
21	Cardiac muscle contraction_Homo sapiens_hsa04260	1.62088961
22	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.57453064
23	Base excision repair_Homo sapiens_hsa03410	1.52428689
24	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.45281940
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.43512912
26	Nucleotide excision repair_Homo sapiens_hsa03420	1.42838643
27	Collecting duct acid secretion_Homo sapiens_hsa04966	1.39315877
28	Nicotine addiction_Homo sapiens_hsa05033	1.38878945
29	Pyrimidine metabolism_Homo sapiens_hsa00240	1.35880668
30	RNA degradation_Homo sapiens_hsa03018	1.33774636
31	Basal transcription factors_Homo sapiens_hsa03022	1.32315695
32	DNA replication_Homo sapiens_hsa03030	1.31712333
33	Propanoate metabolism_Homo sapiens_hsa00640	1.26381961
34	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.24228952
35	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.22975126
36	Tryptophan metabolism_Homo sapiens_hsa00380	1.19716991
37	Purine metabolism_Homo sapiens_hsa00230	1.19325075
38	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.18256413
39	Spliceosome_Homo sapiens_hsa03040	1.11572795
40	Peroxisome_Homo sapiens_hsa04146	1.10366098
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.02287018
42	Regulation of autophagy_Homo sapiens_hsa04140	1.01611425
43	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.00273827
44	Nitrogen metabolism_Homo sapiens_hsa00910	0.96921185
45	Sulfur metabolism_Homo sapiens_hsa00920	0.95819700
46	Linoleic acid metabolism_Homo sapiens_hsa00591	0.94201283
47	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.92579511
48	Non-homologous end-joining_Homo sapiens_hsa03450	0.91164672
49	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.88125793
50	Metabolic pathways_Homo sapiens_hsa01100	0.87512576
51	One carbon pool by folate_Homo sapiens_hsa00670	0.86355240
52	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.86286353
53	Glutathione metabolism_Homo sapiens_hsa00480	0.85243849
54	RNA transport_Homo sapiens_hsa03013	0.82142444
55	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.77041814
56	GABAergic synapse_Homo sapiens_hsa04727	0.76928980
57	Caffeine metabolism_Homo sapiens_hsa00232	0.76234195
58	Selenocompound metabolism_Homo sapiens_hsa00450	0.75498910
59	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.73177695
60	Taste transduction_Homo sapiens_hsa04742	0.71200678
61	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.68605829
62	Folate biosynthesis_Homo sapiens_hsa00790	0.68587821
63	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.68125550
64	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.67935820
65	Ether lipid metabolism_Homo sapiens_hsa00565	0.67315351
66	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.63164824
67	Chemical carcinogenesis_Homo sapiens_hsa05204	0.63106876
68	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.61339264
69	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.61296325
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.59716659
71	Morphine addiction_Homo sapiens_hsa05032	0.56938203
72	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.55661792
73	Fatty acid metabolism_Homo sapiens_hsa01212	0.52656819
74	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.51929256
75	Steroid biosynthesis_Homo sapiens_hsa00100	0.50331974
76	Olfactory transduction_Homo sapiens_hsa04740	0.47774001
77	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.47553025
78	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.46399987
79	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.44552475
80	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.42011888
81	Vibrio cholerae infection_Homo sapiens_hsa05110	0.40351652
82	Retinol metabolism_Homo sapiens_hsa00830	0.40315849
83	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.39063240
84	Oocyte meiosis_Homo sapiens_hsa04114	0.36827919
85	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.36743278
86	Circadian entrainment_Homo sapiens_hsa04713	0.36270097
87	Pyruvate metabolism_Homo sapiens_hsa00620	0.34826304
88	Serotonergic synapse_Homo sapiens_hsa04726	0.34475872
89	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.34463271
90	Glutamatergic synapse_Homo sapiens_hsa04724	0.34436438
91	Sulfur relay system_Homo sapiens_hsa04122	0.32848609
92	Tyrosine metabolism_Homo sapiens_hsa00350	0.32442733
93	Fatty acid degradation_Homo sapiens_hsa00071	0.31359017
94	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.30770012
95	beta-Alanine metabolism_Homo sapiens_hsa00410	0.30175878
96	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.30038692
97	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.28716965
98	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.27345164
99	Rheumatoid arthritis_Homo sapiens_hsa05323	0.26785585
100	ABC transporters_Homo sapiens_hsa02010	0.26717493

PMS2P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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