PMS2P7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein complex biogenesis (GO:0070271)5.02384545
2mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.71330035
3mitochondrial respiratory chain complex I assembly (GO:0032981)4.71330035
4NADH dehydrogenase complex assembly (GO:0010257)4.71330035
5mitochondrial respiratory chain complex assembly (GO:0033108)4.70247264
6DNA deamination (GO:0045006)4.63257061
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.53282875
8respiratory chain complex IV assembly (GO:0008535)4.45811499
9rRNA modification (GO:0000154)4.27577159
10mismatch repair (GO:0006298)4.24926123
11cytochrome complex assembly (GO:0017004)4.16158126
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.07244658
13energy coupled proton transport, down electrochemical gradient (GO:0015985)4.07093621
14ATP synthesis coupled proton transport (GO:0015986)4.07093621
15protein deneddylation (GO:0000338)4.05663136
16cullin deneddylation (GO:0010388)3.98842813
17rRNA methylation (GO:0031167)3.84513856
18mannosylation (GO:0097502)3.81251179
19nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.70615164
20regulation of mitochondrial translation (GO:0070129)3.69620555
21exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.64941294
22chaperone-mediated protein transport (GO:0072321)3.63141219
23establishment of protein localization to mitochondrial membrane (GO:0090151)3.55614743
24respiratory electron transport chain (GO:0022904)3.53341622
25maturation of 5.8S rRNA (GO:0000460)3.50265179
26electron transport chain (GO:0022900)3.50155410
27DNA double-strand break processing (GO:0000729)3.49044490
28protein localization to kinetochore (GO:0034501)3.47158177
29pseudouridine synthesis (GO:0001522)3.38068393
30negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.36006745
31adenosine metabolic process (GO:0046085)3.34544366
32preassembly of GPI anchor in ER membrane (GO:0016254)3.32563575
33water-soluble vitamin biosynthetic process (GO:0042364)3.29384525
34attachment of spindle microtubules to kinetochore (GO:0008608)3.25984594
35base-excision repair, AP site formation (GO:0006285)3.21047615
36DNA ligation (GO:0006266)3.19068325
37positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.17017879
38DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.16711832
39platelet dense granule organization (GO:0060155)3.15691413
40signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.14310187
41signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.14310187
42signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.14310187
43peptidyl-histidine modification (GO:0018202)3.12611911
44tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.12428709
45RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.12428709
46negative regulation of telomere maintenance (GO:0032205)3.08861313
47regulation of cellular amino acid metabolic process (GO:0006521)3.08563360
48regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.07659841
49protein-cofactor linkage (GO:0018065)3.07324965
50intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.06567585
51signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.06567585
52GPI anchor biosynthetic process (GO:0006506)3.03996761
53inner mitochondrial membrane organization (GO:0007007)3.01060163
54L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.00126285
55GPI anchor metabolic process (GO:0006505)2.97046939
56regulation of mitotic spindle checkpoint (GO:1903504)2.97044527
57regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.97044527
58tRNA processing (GO:0008033)2.96890072
59signal transduction involved in DNA integrity checkpoint (GO:0072401)2.96810467
60signal transduction involved in DNA damage checkpoint (GO:0072422)2.96810467
61signal transduction involved in cell cycle checkpoint (GO:0072395)2.96296787
62tRNA modification (GO:0006400)2.93969267
63negative regulation of ligase activity (GO:0051352)2.92076799
64negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.92076799
65somatic hypermutation of immunoglobulin genes (GO:0016446)2.91509549
66somatic diversification of immune receptors via somatic mutation (GO:0002566)2.91509549
67behavioral response to nicotine (GO:0035095)2.91099382
68ubiquinone biosynthetic process (GO:0006744)2.88263914
69sequestering of actin monomers (GO:0042989)2.88151457
70anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.87518235
71L-fucose catabolic process (GO:0042355)2.86895862
72fucose catabolic process (GO:0019317)2.86895862
73L-fucose metabolic process (GO:0042354)2.86895862
74proteasome assembly (GO:0043248)2.86690604
75pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.86378355
76ribosomal small subunit assembly (GO:0000028)2.86103235
77DNA catabolic process, exonucleolytic (GO:0000738)2.83085272
78positive regulation of prostaglandin secretion (GO:0032308)2.81724635
79C-terminal protein lipidation (GO:0006501)2.80944987
80transcription elongation from RNA polymerase III promoter (GO:0006385)2.80090655
81termination of RNA polymerase III transcription (GO:0006386)2.80090655
82positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.77666546
83GTP biosynthetic process (GO:0006183)2.75624095
84mitochondrial RNA metabolic process (GO:0000959)2.75196682
85histone H2A acetylation (GO:0043968)2.75005114
86protein prenylation (GO:0018342)2.72487017
87prenylation (GO:0097354)2.72487017
88ribosomal large subunit biogenesis (GO:0042273)2.70448709
89replication fork processing (GO:0031297)2.69522532
90regulation of helicase activity (GO:0051095)2.66879780
91pyrimidine nucleotide catabolic process (GO:0006244)2.66426921
92ubiquinone metabolic process (GO:0006743)2.65300229
93tRNA metabolic process (GO:0006399)2.64898034
94spliceosomal snRNP assembly (GO:0000387)2.64316690
95DNA damage response, detection of DNA damage (GO:0042769)2.64055229
96amino acid salvage (GO:0043102)2.63507110
97L-methionine salvage (GO:0071267)2.63507110
98L-methionine biosynthetic process (GO:0071265)2.63507110
99positive regulation of ligase activity (GO:0051351)2.62708484
100RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.60789815

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.12698705
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.54403020
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.18526206
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.92190699
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.63268064
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.40638839
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.34914706
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.24793378
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.12930969
10VDR_23849224_ChIP-Seq_CD4+_Human2.94260132
11ZNF274_21170338_ChIP-Seq_K562_Hela2.90570445
12ELK1_19687146_ChIP-ChIP_HELA_Human2.78395965
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.60064311
14SRF_21415370_ChIP-Seq_HL-1_Mouse2.58463753
15FOXP3_21729870_ChIP-Seq_TREG_Human2.55011528
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.47474143
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.43478257
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.26621468
19MYC_18940864_ChIP-ChIP_HL60_Human2.08673075
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.07691173
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.06403502
22PADI4_21655091_ChIP-ChIP_MCF-7_Human1.98643490
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.94343648
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83382530
25IGF1R_20145208_ChIP-Seq_DFB_Human1.81435710
26VDR_22108803_ChIP-Seq_LS180_Human1.81391264
27EWS_26573619_Chip-Seq_HEK293_Human1.78157544
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.77668594
29DCP1A_22483619_ChIP-Seq_HELA_Human1.74722991
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73739269
31FUS_26573619_Chip-Seq_HEK293_Human1.65943296
32TAF15_26573619_Chip-Seq_HEK293_Human1.64320447
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.63616974
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.62289591
35HOXB4_20404135_ChIP-ChIP_EML_Mouse1.61282217
36GABP_19822575_ChIP-Seq_HepG2_Human1.60055896
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57478868
38TTF2_22483619_ChIP-Seq_HELA_Human1.56300090
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.55797206
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52231650
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51878461
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49589674
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.49283065
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46640594
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.42812234
46MYC_19030024_ChIP-ChIP_MESCs_Mouse1.42524715
47CIITA_25753668_ChIP-Seq_RAJI_Human1.42380317
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39128735
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34966050
50ELK1_22589737_ChIP-Seq_MCF10A_Human1.32445751
51TP53_22573176_ChIP-Seq_HFKS_Human1.32278528
52XRN2_22483619_ChIP-Seq_HELA_Human1.32025993
53IRF1_19129219_ChIP-ChIP_H3396_Human1.31919051
54E2F1_18555785_ChIP-Seq_MESCs_Mouse1.31790460
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26741517
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20315605
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.19701099
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17786509
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17220749
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16760942
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12570864
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11924064
63P300_19829295_ChIP-Seq_ESCs_Human1.11458454
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10427434
65FOXA1_25329375_ChIP-Seq_VCAP_Human1.10043106
66FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10043106
67KDM5A_27292631_Chip-Seq_BREAST_Human1.08065346
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.07942501
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07454242
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06575985
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05708434
72MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05239475
73FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04901700
74AR_20517297_ChIP-Seq_VCAP_Human1.03363963
75CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02802967
76BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01928524
77NELFA_20434984_ChIP-Seq_ESCs_Mouse1.01068544
78GBX2_23144817_ChIP-Seq_PC3_Human1.00372045
79EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.94898287
80ER_23166858_ChIP-Seq_MCF-7_Human0.94769266
81ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93168085
82GATA3_26560356_Chip-Seq_TH2_Human0.92164515
83NANOG_19829295_ChIP-Seq_ESCs_Human0.91650227
84SOX2_19829295_ChIP-Seq_ESCs_Human0.91650227
85MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.90712269
86POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89531721
87NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.88942297
88CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.87464741
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86756742
90CBP_20019798_ChIP-Seq_JUKART_Human0.86756742
91SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86378160
92NCOR_22424771_ChIP-Seq_293T_Human0.86065681
93IRF8_22096565_ChIP-ChIP_GC-B_Human0.85970905
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84485054
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.84063068
96ERG_20887958_ChIP-Seq_HPC-7_Mouse0.81279802
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80850760
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.80644159
99NFE2_27457419_Chip-Seq_LIVER_Mouse0.79882015
100SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.79164939

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.52108420
2MP0001529_abnormal_vocalization2.81929846
3MP0002736_abnormal_nociception_after2.74947568
4MP0008877_abnormal_DNA_methylation2.70000919
5MP0006072_abnormal_retinal_apoptosis2.68394460
6MP0000372_irregular_coat_pigmentation2.47025110
7MP0004147_increased_porphyrin_level2.34228101
8MP0003786_premature_aging2.27686393
9MP0005075_abnormal_melanosome_morpholog2.23001298
10MP0005084_abnormal_gallbladder_morpholo2.21172186
11MP0001968_abnormal_touch/_nociception2.16702869
12MP0010094_abnormal_chromosome_stability2.15010383
13MP0003718_maternal_effect2.08584538
14MP0005645_abnormal_hypothalamus_physiol2.08018831
15MP0002938_white_spotting2.00062558
16MP0003011_delayed_dark_adaptation1.99595892
17MP0008995_early_reproductive_senescence1.95407190
18MP0003195_calcinosis1.94043107
19MP0005646_abnormal_pituitary_gland1.88752123
20MP0009697_abnormal_copulation1.87536319
21MP0006036_abnormal_mitochondrial_physio1.84308335
22MP0003787_abnormal_imprinting1.82732927
23MP0005551_abnormal_eye_electrophysiolog1.80649590
24MP0003880_abnormal_central_pattern1.76913773
25MP0005253_abnormal_eye_physiology1.76619705
26MP0006276_abnormal_autonomic_nervous1.74723382
27MP0008875_abnormal_xenobiotic_pharmacok1.72688859
28MP0003693_abnormal_embryo_hatching1.70598718
29MP0002653_abnormal_ependyma_morphology1.69081973
30MP0001905_abnormal_dopamine_level1.66042168
31MP0002102_abnormal_ear_morphology1.58332585
32MP0006035_abnormal_mitochondrial_morpho1.54464322
33MP0001986_abnormal_taste_sensitivity1.54320633
34MP0008872_abnormal_physiological_respon1.53654039
35MP0006292_abnormal_olfactory_placode1.51061624
36MP0004142_abnormal_muscle_tone1.43966915
37MP0003186_abnormal_redox_activity1.42139262
38MP0001764_abnormal_homeostasis1.41657578
39MP0001501_abnormal_sleep_pattern1.41390856
40MP0003111_abnormal_nucleus_morphology1.41324337
41MP0002876_abnormal_thyroid_physiology1.37936178
42MP0003806_abnormal_nucleotide_metabolis1.30366169
43MP0003121_genomic_imprinting1.29375686
44MP0000569_abnormal_digit_pigmentation1.25789903
45MP0002837_dystrophic_cardiac_calcinosis1.23772881
46MP0004133_heterotaxia1.23723054
47MP0004145_abnormal_muscle_electrophysio1.21982899
48MP0001984_abnormal_olfaction1.19845106
49MP0008789_abnormal_olfactory_epithelium1.18353049
50MP0002822_catalepsy1.14197465
51MP0009046_muscle_twitch1.12089660
52MP0002272_abnormal_nervous_system1.10128309
53MP0000631_abnormal_neuroendocrine_gland1.09981318
54MP0004957_abnormal_blastocyst_morpholog1.06700498
55MP0002735_abnormal_chemical_nociception1.05765087
56MP0003077_abnormal_cell_cycle1.05080042
57MP0002234_abnormal_pharynx_morphology1.05048583
58MP0009745_abnormal_behavioral_response1.04652878
59MP0010386_abnormal_urinary_bladder0.98627043
60MP0008775_abnormal_heart_ventricle0.95094798
61MP0001486_abnormal_startle_reflex0.94633145
62MP0005174_abnormal_tail_pigmentation0.94567827
63MP0002751_abnormal_autonomic_nervous0.94173094
64MP0002095_abnormal_skin_pigmentation0.93432376
65MP0002148_abnormal_hypersensitivity_rea0.90869580
66MP0001929_abnormal_gametogenesis0.90448780
67MP0002557_abnormal_social/conspecific_i0.89927430
68MP0005499_abnormal_olfactory_system0.89562433
69MP0005394_taste/olfaction_phenotype0.89562433
70MP0008007_abnormal_cellular_replicative0.88885776
71MP0005671_abnormal_response_to0.88605648
72MP0004885_abnormal_endolymph0.88337524
73MP0008932_abnormal_embryonic_tissue0.87791331
74MP0002733_abnormal_thermal_nociception0.86983861
75MP0002928_abnormal_bile_duct0.81417750
76MP0000358_abnormal_cell_content/0.80678418
77MP0000689_abnormal_spleen_morphology0.77314041
78MP0004742_abnormal_vestibular_system0.77219040
79MP0002572_abnormal_emotion/affect_behav0.76444787
80MP0001919_abnormal_reproductive_system0.76108108
81MP0001119_abnormal_female_reproductive0.74862513
82MP0000516_abnormal_urinary_system0.74052126
83MP0005367_renal/urinary_system_phenotyp0.74052126
84MP0000465_gastrointestinal_hemorrhage0.73231956
85MP0002277_abnormal_respiratory_mucosa0.72930552
86MP0002019_abnormal_tumor_incidence0.72709205
87MP0002210_abnormal_sex_determination0.71480221
88MP0005423_abnormal_somatic_nervous0.71299470
89MP0005389_reproductive_system_phenotype0.70353409
90MP0005395_other_phenotype0.70154009
91MP0003698_abnormal_male_reproductive0.70151646
92MP0001293_anophthalmia0.69265217
93MP0000653_abnormal_sex_gland0.68617791
94MP0003136_yellow_coat_color0.67815940
95MP0005266_abnormal_metabolism0.67639229
96MP0001145_abnormal_male_reproductive0.67481013
97MP0005332_abnormal_amino_acid0.66554365
98MP0002282_abnormal_trachea_morphology0.66232204
99MP0005410_abnormal_fertilization0.64993631
100MP0006054_spinal_hemorrhage0.64140233

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.71352669
2Mitochondrial inheritance (HP:0001427)4.59391038
3Abnormal mitochondria in muscle tissue (HP:0008316)4.33277166
4Hepatocellular necrosis (HP:0001404)4.19821552
5Acute encephalopathy (HP:0006846)4.14963209
6Increased CSF lactate (HP:0002490)4.14418201
7Increased hepatocellular lipid droplets (HP:0006565)4.02492983
8Progressive macrocephaly (HP:0004481)3.99927453
9Lipid accumulation in hepatocytes (HP:0006561)3.91647172
10Hepatic necrosis (HP:0002605)3.82825038
11Renal Fanconi syndrome (HP:0001994)3.66242033
12Pancreatic cysts (HP:0001737)3.21022948
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.17497799
14Pancreatic fibrosis (HP:0100732)3.16199134
15Cerebral edema (HP:0002181)3.10404775
16Type I transferrin isoform profile (HP:0003642)3.09941229
17Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.04381015
18Abnormal protein N-linked glycosylation (HP:0012347)3.04381015
19Abnormal protein glycosylation (HP:0012346)3.04381015
20Abnormal glycosylation (HP:0012345)3.04381015
21Microvesicular hepatic steatosis (HP:0001414)2.98946623
22Increased intramyocellular lipid droplets (HP:0012240)2.88695206
23Renal cortical cysts (HP:0000803)2.85580903
24Degeneration of anterior horn cells (HP:0002398)2.80978446
25Abnormality of the anterior horn cell (HP:0006802)2.80978446
263-Methylglutaconic aciduria (HP:0003535)2.79980719
27Increased serum lactate (HP:0002151)2.77557183
28True hermaphroditism (HP:0010459)2.74583455
29Medial flaring of the eyebrow (HP:0010747)2.73403425
30Lactic acidosis (HP:0003128)2.69635302
31Nephronophthisis (HP:0000090)2.64312311
32Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.62938205
33Methylmalonic acidemia (HP:0002912)2.61687653
34Abnormal number of erythroid precursors (HP:0012131)2.61094302
35Colon cancer (HP:0003003)2.59645585
36Exercise intolerance (HP:0003546)2.56721397
37Optic disc pallor (HP:0000543)2.54385412
38Abnormality of midbrain morphology (HP:0002418)2.52685784
39Molar tooth sign on MRI (HP:0002419)2.52685784
40Increased muscle lipid content (HP:0009058)2.48834269
41Exertional dyspnea (HP:0002875)2.47212079
42Abnormality of the renal cortex (HP:0011035)2.46319865
43Abolished electroretinogram (ERG) (HP:0000550)2.45612264
44Severe combined immunodeficiency (HP:0004430)2.38793530
45Respiratory failure (HP:0002878)2.34779375
46Methylmalonic aciduria (HP:0012120)2.30157287
47Type II lissencephaly (HP:0007260)2.29242813
48Abnormality of aspartate family amino acid metabolism (HP:0010899)2.29087985
49Decreased central vision (HP:0007663)2.28413324
50Abnormality of renal resorption (HP:0011038)2.28399343
51Bile duct proliferation (HP:0001408)2.24509237
52Abnormal biliary tract physiology (HP:0012439)2.24509237
53Congenital, generalized hypertrichosis (HP:0004540)2.23934815
54Attenuation of retinal blood vessels (HP:0007843)2.22475474
55Decreased activity of mitochondrial respiratory chain (HP:0008972)2.21619547
56Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.21619547
57Dicarboxylic aciduria (HP:0003215)2.18121990
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.18121990
59Aplastic anemia (HP:0001915)2.15114947
60Lethargy (HP:0001254)2.13419518
61Abnormality of the renal medulla (HP:0100957)2.13414652
62Cerebellar dysplasia (HP:0007033)2.10545112
63Abnormality of methionine metabolism (HP:0010901)2.08609639
64Congenital primary aphakia (HP:0007707)2.05382173
65Gait imbalance (HP:0002141)2.05073068
66Retinal dysplasia (HP:0007973)2.04493758
67Abnormality of cells of the erythroid lineage (HP:0012130)2.03143475
68Abnormality of lateral ventricle (HP:0030047)2.02724507
69Pancytopenia (HP:0001876)1.99762608
70Glycosuria (HP:0003076)1.99360244
71Abnormality of urine glucose concentration (HP:0011016)1.99360244
72Oral leukoplakia (HP:0002745)1.96920856
73Abnormality of the pons (HP:0007361)1.94679679
74Atrophy/Degeneration involving motor neurons (HP:0007373)1.94231368
75Panhypogammaglobulinemia (HP:0003139)1.93920837
76Decreased electroretinogram (ERG) amplitude (HP:0000654)1.92933875
77Hypoplasia of the pons (HP:0012110)1.92616189
78Nephrogenic diabetes insipidus (HP:0009806)1.91557600
79IgG deficiency (HP:0004315)1.90935137
80Pendular nystagmus (HP:0012043)1.90903999
81Congenital stationary night blindness (HP:0007642)1.90676446
82Hypothermia (HP:0002045)1.89958757
83Aplasia/hypoplasia of the uterus (HP:0008684)1.88398949
84Progressive microcephaly (HP:0000253)1.87605340
85Leukodystrophy (HP:0002415)1.86691771
86CNS demyelination (HP:0007305)1.85991293
87Abnormality of the prostate (HP:0008775)1.85947864
88Generalized aminoaciduria (HP:0002909)1.82734593
89Combined immunodeficiency (HP:0005387)1.82243440
90Sclerocornea (HP:0000647)1.81442463
91Stomach cancer (HP:0012126)1.81310511
92Aplasia/Hypoplasia of the tongue (HP:0010295)1.76686560
93Abnormality of the heme biosynthetic pathway (HP:0010472)1.75066058
94Male pseudohermaphroditism (HP:0000037)1.75042933
95Abnormal rod and cone electroretinograms (HP:0008323)1.71254803
96Prostate neoplasm (HP:0100787)1.70708739
97Respiratory difficulties (HP:0002880)1.70384912
98Emotional lability (HP:0000712)1.70276946
99Cystic liver disease (HP:0006706)1.69755435
100Hyperglycinuria (HP:0003108)1.69429163

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.79623094
2NUAK13.58527611
3TAOK33.25341244
4ZAK3.22211277
5MAP4K23.16475406
6STK162.62993502
7WNK32.56673282
8VRK12.28700546
9TAF12.13988346
10BUB11.97142882
11MST41.93247003
12CDC71.81751928
13CCNB11.70760091
14FRK1.69071170
15TLK11.69051904
16EIF2AK31.68675496
17SRPK11.65022308
18BCKDK1.56959507
19BMPR1B1.56571304
20PBK1.51979027
21TNIK1.45715813
22INSRR1.39112920
23PLK31.32498066
24TESK21.32355540
25MAP3K41.28027500
26NME11.25780095
27MAP3K121.24085642
28GRK11.20732419
29EIF2AK21.18399206
30TRIM281.18324515
31MAPK131.16987992
32ADRBK21.14964670
33CSNK1G31.14025942
34DYRK21.13404052
35BRSK21.10199496
36TXK1.02418375
37KIT0.98327964
38MAP2K70.96626626
39IKBKB0.96449582
40MKNK10.96012315
41CSNK1G10.93566295
42CSNK1G20.92740027
43FLT30.91151595
44TEC0.90774965
45DAPK10.87966222
46ATR0.87691784
47ERBB30.85753243
48MKNK20.85716194
49NEK10.83779009
50TTK0.82344659
51PDK20.80659855
52PINK10.78091421
53CSNK1A1L0.76297997
54PLK40.76284809
55WEE10.74204485
56TIE10.74171630
57EIF2AK10.74043755
58PLK20.73552798
59GRK60.67024598
60PLK10.66305281
61IRAK10.64986302
62PHKG20.64682685
63PHKG10.64682685
64DYRK30.61036179
65BCR0.60959043
66KDR0.60778243
67TSSK60.60307572
68MAP2K20.59798632
69CHEK20.58927614
70SYK0.58782658
71RPS6KA50.57555446
72CSF1R0.56898910
73CDK80.56830266
74MAPKAPK30.56327626
75CASK0.54190287
76PRKCQ0.52755278
77MAPKAPK50.51667780
78PAK30.51326535
79MAP4K10.50425453
80AURKB0.50409484
81PIM20.50323152
82IKBKE0.47447610
83PRKCG0.45517980
84MUSK0.44881857
85PKN10.44596533
86LIMK10.44095521
87LYN0.43987739
88PRKCE0.43287026
89MAP3K140.41729039
90FES0.41724393
91ITK0.40359020
92MARK10.40045556
93TBK10.39666160
94OXSR10.39367689
95CSNK2A10.38654376
96CSNK2A20.36601577
97ATM0.35383484
98AURKA0.34783569
99RPS6KA40.34685892
100MAP3K50.32981771

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.96104800
2Oxidative phosphorylation_Homo sapiens_hsa001903.52341086
3Protein export_Homo sapiens_hsa030603.50034097
4Parkinsons disease_Homo sapiens_hsa050123.07068436
5RNA polymerase_Homo sapiens_hsa030202.71573312
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.33416085
7Ribosome_Homo sapiens_hsa030102.30657720
8Homologous recombination_Homo sapiens_hsa034402.26936209
9Mismatch repair_Homo sapiens_hsa034302.15565581
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.11779636
11Base excision repair_Homo sapiens_hsa034102.10845581
12Huntingtons disease_Homo sapiens_hsa050162.04373123
13DNA replication_Homo sapiens_hsa030302.00807140
14Fanconi anemia pathway_Homo sapiens_hsa034601.99132951
15Basal transcription factors_Homo sapiens_hsa030221.96002698
16Alzheimers disease_Homo sapiens_hsa050101.87902509
17RNA degradation_Homo sapiens_hsa030181.85422506
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82724378
19Fatty acid elongation_Homo sapiens_hsa000621.81177043
20Spliceosome_Homo sapiens_hsa030401.76067686
21Non-homologous end-joining_Homo sapiens_hsa034501.74119233
22Nucleotide excision repair_Homo sapiens_hsa034201.70128424
23Phototransduction_Homo sapiens_hsa047441.68679183
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60324537
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.57740638
26Pyrimidine metabolism_Homo sapiens_hsa002401.55869145
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54265172
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.47301617
29Peroxisome_Homo sapiens_hsa041461.40872781
30One carbon pool by folate_Homo sapiens_hsa006701.36397342
31Purine metabolism_Homo sapiens_hsa002301.35295543
32RNA transport_Homo sapiens_hsa030131.31788184
33Primary immunodeficiency_Homo sapiens_hsa053401.30888002
34Butanoate metabolism_Homo sapiens_hsa006501.29137790
35Propanoate metabolism_Homo sapiens_hsa006401.29073253
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28011160
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19464549
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17749399
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.17362478
40Sulfur metabolism_Homo sapiens_hsa009201.16219416
41Nitrogen metabolism_Homo sapiens_hsa009101.14374726
42Tryptophan metabolism_Homo sapiens_hsa003801.10788691
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.09668753
44Cardiac muscle contraction_Homo sapiens_hsa042601.09522534
45Selenocompound metabolism_Homo sapiens_hsa004501.05760513
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03973218
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.03191180
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99172417
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97587992
50Pyruvate metabolism_Homo sapiens_hsa006200.83840864
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83606478
52Metabolic pathways_Homo sapiens_hsa011000.83135053
53Nicotine addiction_Homo sapiens_hsa050330.80426015
54Linoleic acid metabolism_Homo sapiens_hsa005910.80421945
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79481236
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.79425602
57Glutathione metabolism_Homo sapiens_hsa004800.78456730
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75088031
59Collecting duct acid secretion_Homo sapiens_hsa049660.74671962
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74412822
61Caffeine metabolism_Homo sapiens_hsa002320.74370307
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71127882
63Regulation of autophagy_Homo sapiens_hsa041400.70956320
64Folate biosynthesis_Homo sapiens_hsa007900.65669546
65Chemical carcinogenesis_Homo sapiens_hsa052040.63728546
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63516364
67N-Glycan biosynthesis_Homo sapiens_hsa005100.62417406
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61861166
69Ether lipid metabolism_Homo sapiens_hsa005650.61015765
70Taste transduction_Homo sapiens_hsa047420.60406844
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55633524
72Asthma_Homo sapiens_hsa053100.53249520
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52960257
74Type I diabetes mellitus_Homo sapiens_hsa049400.51678049
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51478270
76Oocyte meiosis_Homo sapiens_hsa041140.50953482
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49811476
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49700139
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.49433819
80Fatty acid metabolism_Homo sapiens_hsa012120.46138158
81Arachidonic acid metabolism_Homo sapiens_hsa005900.45624144
82Rheumatoid arthritis_Homo sapiens_hsa053230.43097325
83Olfactory transduction_Homo sapiens_hsa047400.42866345
84beta-Alanine metabolism_Homo sapiens_hsa004100.40184908
85Retinol metabolism_Homo sapiens_hsa008300.38608341
86Steroid biosynthesis_Homo sapiens_hsa001000.38474725
87Cell cycle_Homo sapiens_hsa041100.37046905
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.35891717
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31256006
90Allograft rejection_Homo sapiens_hsa053300.31060617
91p53 signaling pathway_Homo sapiens_hsa041150.31011229
92Epstein-Barr virus infection_Homo sapiens_hsa051690.30603935
93Carbon metabolism_Homo sapiens_hsa012000.27527762
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27155557
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27047489
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26275423
97Glycerolipid metabolism_Homo sapiens_hsa005610.25021977
98mRNA surveillance pathway_Homo sapiens_hsa030150.24248716
99Fatty acid degradation_Homo sapiens_hsa000710.23506012
100Tyrosine metabolism_Homo sapiens_hsa003500.22077268

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