ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	neurofilament cytoskeleton organization (GO:0060052)	7.26171981
2	rRNA methylation (GO:0031167)	4.91640181
3	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.84847490
4	NADH dehydrogenase complex assembly (GO:0010257)	4.84847490
5	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.84847490
6	rRNA modification (GO:0000154)	4.48112428
7	platelet dense granule organization (GO:0060155)	4.43316166
8	behavioral response to nicotine (GO:0035095)	4.29112888
9	regulation of cilium movement (GO:0003352)	4.27376171
10	organelle disassembly (GO:1903008)	4.25097605
11	ribonucleoprotein complex disassembly (GO:0032988)	4.13743222
12	mitochondrial respiratory chain complex assembly (GO:0033108)	4.12354790
13	L-fucose catabolic process (GO:0042355)	4.11687398
14	fucose catabolic process (GO:0019317)	4.11687398
15	L-fucose metabolic process (GO:0042354)	4.11687398
16	protein complex biogenesis (GO:0070271)	4.10126983
17	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.07244409
18	protein targeting to Golgi (GO:0000042)	4.06317286
19	establishment of protein localization to Golgi (GO:0072600)	4.00220851
20	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.88629452
21	relaxation of smooth muscle (GO:0044557)	3.79766765
22	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.72141105
23	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.66738369
24	C4-dicarboxylate transport (GO:0015740)	3.62664208
25	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.58007440
26	prenylation (GO:0097354)	3.50390577
27	protein prenylation (GO:0018342)	3.50390577
28	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	3.48932952
29	DNA deamination (GO:0045006)	3.45357766
30	response to pheromone (GO:0019236)	3.42567185
31	mature B cell differentiation (GO:0002335)	3.41320125
32	chaperone-mediated protein transport (GO:0072321)	3.36040234
33	cilium or flagellum-dependent cell motility (GO:0001539)	3.35336988
34	epithelial cilium movement (GO:0003351)	3.35026810
35	anterograde synaptic vesicle transport (GO:0048490)	3.34112977
36	DNA damage response, detection of DNA damage (GO:0042769)	3.33834660
37	positive regulation of steroid hormone secretion (GO:2000833)	3.28500921
38	ubiquinone biosynthetic process (GO:0006744)	3.27331365
39	protein localization to Golgi apparatus (GO:0034067)	3.21734964
40	GTP biosynthetic process (GO:0006183)	3.20616858
41	ribosomal small subunit assembly (GO:0000028)	3.17715653
42	respiratory electron transport chain (GO:0022904)	3.17069070
43	electron transport chain (GO:0022900)	3.16341217
44	pseudouridine synthesis (GO:0001522)	3.10279403
45	germ cell migration (GO:0008354)	3.10045416
46	ubiquinone metabolic process (GO:0006743)	3.09646399
47	anterograde axon cargo transport (GO:0008089)	3.06793671
48	actin nucleation (GO:0045010)	3.04360701
49	phenylpropanoid metabolic process (GO:0009698)	3.01415219
50	regulation of meiosis I (GO:0060631)	3.00713413
51	preassembly of GPI anchor in ER membrane (GO:0016254)	2.97368266
52	protein targeting to mitochondrion (GO:0006626)	2.96823816
53	startle response (GO:0001964)	2.96359005
54	central nervous system projection neuron axonogenesis (GO:0021952)	2.94838447
55	neural tube formation (GO:0001841)	2.94357300
56	nonmotile primary cilium assembly (GO:0035058)	2.91932759
57	sympathetic nervous system development (GO:0048485)	2.91251163
58	positive regulation of calcium ion import (GO:0090280)	2.90150488
59	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.89852410
60	mitochondrial RNA metabolic process (GO:0000959)	2.88449340
61	regulation of Rac GTPase activity (GO:0032314)	2.82774146
62	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.82195670
63	ATP synthesis coupled proton transport (GO:0015986)	2.82195670
64	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.81356590
65	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.81356590
66	establishment of protein localization to mitochondrion (GO:0072655)	2.76175949
67	negative regulation of norepinephrine secretion (GO:0010700)	2.75759047
68	aggressive behavior (GO:0002118)	2.74334099
69	mature B cell differentiation involved in immune response (GO:0002313)	2.74220605
70	regulation of microtubule-based movement (GO:0060632)	2.71843668
71	regulation of dopamine secretion (GO:0014059)	2.70618646
72	positive regulation of vasculogenesis (GO:2001214)	2.69030513
73	intraciliary transport (GO:0042073)	2.68255888
74	mismatch repair (GO:0006298)	2.67093083
75	RNA methylation (GO:0001510)	2.66393366
76	detection of light stimulus involved in sensory perception (GO:0050962)	2.65735758
77	detection of light stimulus involved in visual perception (GO:0050908)	2.65735758
78	opioid receptor signaling pathway (GO:0038003)	2.65304287
79	protein neddylation (GO:0045116)	2.64368048
80	protein sumoylation (GO:0016925)	2.64121282
81	quinone biosynthetic process (GO:1901663)	2.62028359
82	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.59313481
83	termination of RNA polymerase III transcription (GO:0006386)	2.58349377
84	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.58349377
85	histone H2A ubiquitination (GO:0033522)	2.57576314
86	auditory receptor cell stereocilium organization (GO:0060088)	2.56840286
87	protein polyglutamylation (GO:0018095)	2.56493062
88	cilium movement (GO:0003341)	2.56193690
89	positive regulation of amino acid transport (GO:0051957)	2.55946527
90	mannosylation (GO:0097502)	2.55716787
91	synaptic transmission, cholinergic (GO:0007271)	2.53928782
92	CTP metabolic process (GO:0046036)	2.50362068
93	CTP biosynthetic process (GO:0006241)	2.50362068
94	UTP biosynthetic process (GO:0006228)	2.50006364
95	respiratory chain complex IV assembly (GO:0008535)	2.49839943
96	UTP metabolic process (GO:0046051)	2.49625077
97	protein localization to mitochondrion (GO:0070585)	2.48799133
98	axon cargo transport (GO:0008088)	2.48504086
99	short-term memory (GO:0007614)	2.47015748
100	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	2.46128294

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.45316894
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.26174240
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.11553768
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.09094991
5	TAF15_26573619_Chip-Seq_HEK293_Human	3.01370164
6	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.97297494
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.84664419
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.78009109
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.72468630
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.71971948
11	EWS_26573619_Chip-Seq_HEK293_Human	2.56503126
12	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.53771289
13	FUS_26573619_Chip-Seq_HEK293_Human	2.48593449
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.44247316
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.42426411
16	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.32485450
17	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.18168219
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.12745100
19	ELK1_19687146_ChIP-ChIP_HELA_Human	2.10989481
20	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.05753099
21	ER_23166858_ChIP-Seq_MCF-7_Human	2.05392031
22	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.05238007
23	VDR_23849224_ChIP-Seq_CD4+_Human	1.97955114
24	VDR_22108803_ChIP-Seq_LS180_Human	1.95148101
25	TP53_22573176_ChIP-Seq_HFKS_Human	1.94472633
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.90754451
27	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.83041192
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.83041192
29	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.82681161
30	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.71991578
31	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.71199510
32	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.68007838
33	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.67193782
34	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.63757841
35	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.63594771
36	BCAT_22108803_ChIP-Seq_LS180_Human	1.61317823
37	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.61057075
38	SMAD4_21799915_ChIP-Seq_A2780_Human	1.55238017
39	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.53223485
40	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.52105478
41	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.51631137
42	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.48668963
43	P300_19829295_ChIP-Seq_ESCs_Human	1.46979181
44	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.46521679
45	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.39204305
46	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.37756575
47	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.36294439
48	AR_20517297_ChIP-Seq_VCAP_Human	1.35945555
49	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35332772
50	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.32071635
51	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.32029046
52	TCF4_22108803_ChIP-Seq_LS180_Human	1.31193037
53	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.29066246
54	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.28158620
55	AR_25329375_ChIP-Seq_VCAP_Human	1.28145574
56	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.26315586
57	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.24869925
58	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.23997399
59	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.23997399
60	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.22438060
61	FOXP3_21729870_ChIP-Seq_TREG_Human	1.22012142
62	MYC_18940864_ChIP-ChIP_HL60_Human	1.21391162
63	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.20448901
64	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19834308
65	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19834308
66	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.18805370
67	RUNX2_22187159_ChIP-Seq_PCA_Human	1.17558741
68	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16404552
69	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.15364820
70	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.13617526
71	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.13500140
72	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.12931722
73	TCF4_23295773_ChIP-Seq_U87_Human	1.10898506
74	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.07420155
75	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.07419045
76	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.07048334
77	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.06525864
78	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.06278588
79	TAF2_19829295_ChIP-Seq_ESCs_Human	1.04888043
80	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.04558882
81	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.04544567
82	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.04334540
83	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04091484
84	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.03710014
85	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.03359257
86	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.03161581
87	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.03005287
88	CDX2_22108803_ChIP-Seq_LS180_Human	1.02472044
89	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.02312129
90	GABP_19822575_ChIP-Seq_HepG2_Human	1.02254245
91	NCOR_22424771_ChIP-Seq_293T_Human	1.02216993
92	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02171097
93	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.01701334
94	STAT3_23295773_ChIP-Seq_U87_Human	1.01113169
95	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.00686169
96	SMRT_27268052_Chip-Seq_Bcells_Human	1.00589264
97	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.00168294
98	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.00098224
99	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.99174380
100	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.98802634

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010386_abnormal_urinary_bladder	4.86817483
2	MP0002102_abnormal_ear_morphology	3.18782023
3	MP0003806_abnormal_nucleotide_metabolis	2.86344731
4	MP0003950_abnormal_plasma_membrane	2.80707613
5	MP0005379_endocrine/exocrine_gland_phen	2.61532784
6	MP0002163_abnormal_gland_morphology	2.54192825
7	MP0000569_abnormal_digit_pigmentation	2.49283796
8	MP0004742_abnormal_vestibular_system	2.36505347
9	MP0002876_abnormal_thyroid_physiology	2.33967645
10	MP0002653_abnormal_ependyma_morphology	2.32815638
11	MP0000538_abnormal_urinary_bladder	2.28797881
12	MP0003787_abnormal_imprinting	2.24224720
13	MP0005551_abnormal_eye_electrophysiolog	2.21701329
14	MP0005645_abnormal_hypothalamus_physiol	2.09432323
15	MP0001529_abnormal_vocalization	2.06573036
16	MP0002735_abnormal_chemical_nociception	1.93875643
17	MP0008875_abnormal_xenobiotic_pharmacok	1.80513894
18	MP0005187_abnormal_penis_morphology	1.75893331
19	MP0005646_abnormal_pituitary_gland	1.73436515
20	MP0002272_abnormal_nervous_system	1.70112453
21	MP0002638_abnormal_pupillary_reflex	1.66993362
22	MP0006276_abnormal_autonomic_nervous	1.64875608
23	MP0004215_abnormal_myocardial_fiber	1.63018557
24	MP0009046_muscle_twitch	1.61254444
25	MP0004145_abnormal_muscle_electrophysio	1.59007298
26	MP0001486_abnormal_startle_reflex	1.58392840
27	MP0001501_abnormal_sleep_pattern	1.53841441
28	MP0008872_abnormal_physiological_respon	1.52365953
29	MP0001764_abnormal_homeostasis	1.51713872
30	MP0000372_irregular_coat_pigmentation	1.50658966
31	MP0009764_decreased_sensitivity_to	1.50397477
32	MP0002822_catalepsy	1.50208144
33	MP0008058_abnormal_DNA_repair	1.49189290
34	MP0002751_abnormal_autonomic_nervous	1.46786562
35	MP0009745_abnormal_behavioral_response	1.46466972
36	MP0004142_abnormal_muscle_tone	1.45786426
37	MP0006072_abnormal_retinal_apoptosis	1.43452676
38	MP0002557_abnormal_social/conspecific_i	1.40515923
39	MP0002009_preneoplasia	1.38773009
40	MP0003011_delayed_dark_adaptation	1.38413185
41	MP0004133_heterotaxia	1.34296667
42	MP0002837_dystrophic_cardiac_calcinosis	1.34293796
43	MP0006036_abnormal_mitochondrial_physio	1.33897476
44	MP0002184_abnormal_innervation	1.30339246
45	MP0003646_muscle_fatigue	1.29700410
46	MP0005410_abnormal_fertilization	1.28831035
47	MP0005310_abnormal_salivary_gland	1.25232254
48	MP0005253_abnormal_eye_physiology	1.24462203
49	MP0003315_abnormal_perineum_morphology	1.23935728
50	MP0001348_abnormal_lacrimal_gland	1.23270035
51	MP0001970_abnormal_pain_threshold	1.23122038
52	MP0003186_abnormal_redox_activity	1.18840608
53	MP0004924_abnormal_behavior	1.18560779
54	MP0005386_behavior/neurological_phenoty	1.18560779
55	MP0000955_abnormal_spinal_cord	1.16980589
56	MP0002938_white_spotting	1.16736955
57	MP0001664_abnormal_digestion	1.14859195
58	MP0002572_abnormal_emotion/affect_behav	1.12831094
59	MP0003718_maternal_effect	1.12698327
60	MP0005670_abnormal_white_adipose	1.12103724
61	MP0009697_abnormal_copulation	1.12085212
62	MP0005085_abnormal_gallbladder_physiolo	1.11878557
63	MP0004043_abnormal_pH_regulation	1.11254201
64	MP0009278_abnormal_bone_marrow	1.08536838
65	MP0003252_abnormal_bile_duct	1.06488683
66	MP0002067_abnormal_sensory_capabilities	1.00268066
67	MP0003121_genomic_imprinting	0.98729642
68	MP0002752_abnormal_somatic_nervous	0.98454384
69	MP0005389_reproductive_system_phenotype	0.93939141
70	MP0001919_abnormal_reproductive_system	0.93244280
71	MP0002733_abnormal_thermal_nociception	0.88097830
72	MP0004084_abnormal_cardiac_muscle	0.87746870
73	MP0005636_abnormal_mineral_homeostasis	0.84896092
74	MP0005647_abnormal_sex_gland	0.84468538
75	MP0009765_abnormal_xenobiotic_induced	0.83882408
76	MP0006035_abnormal_mitochondrial_morpho	0.83695180
77	MP0002736_abnormal_nociception_after	0.81768835
78	MP0003635_abnormal_synaptic_transmissio	0.81322602
79	MP0005332_abnormal_amino_acid	0.80688669
80	MP0001765_abnormal_ion_homeostasis	0.77589133
81	MP0008775_abnormal_heart_ventricle	0.76738044
82	MP0005195_abnormal_posterior_eye	0.76046769
83	MP0005266_abnormal_metabolism	0.75704373
84	MP0003880_abnormal_central_pattern	0.75639430
85	MP0005535_abnormal_body_temperature	0.75547823
86	MP0000647_abnormal_sebaceous_gland	0.73788754
87	MP0002064_seizures	0.73037110
88	MP0003633_abnormal_nervous_system	0.72957977
89	MP0003137_abnormal_impulse_conducting	0.70100846
90	MP0002160_abnormal_reproductive_system	0.69479986
91	MP0003693_abnormal_embryo_hatching	0.68425309
92	MP0002063_abnormal_learning/memory/cond	0.68322065
93	MP0003698_abnormal_male_reproductive	0.67427508
94	MP0002928_abnormal_bile_duct	0.67236158
95	MP0001905_abnormal_dopamine_level	0.67006977
96	MP0002229_neurodegeneration	0.64013555
97	MP0000631_abnormal_neuroendocrine_gland	0.63178502
98	MP0001984_abnormal_olfaction	0.63020424
99	MP0001929_abnormal_gametogenesis	0.62796312
100	MP0002069_abnormal_eating/drinking_beha	0.62704278

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic fibrosis (HP:0100732)	4.59905754
2	Acute necrotizing encephalopathy (HP:0006965)	4.44688041
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.11054168
4	Acute encephalopathy (HP:0006846)	4.09143408
5	Pancreatic cysts (HP:0001737)	4.05571630
6	3-Methylglutaconic aciduria (HP:0003535)	3.86006012
7	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.74703709
8	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.74703709
9	Progressive macrocephaly (HP:0004481)	3.64831804
10	True hermaphroditism (HP:0010459)	3.61553440
11	Tubulointerstitial nephritis (HP:0001970)	3.57257050
12	Cerebral edema (HP:0002181)	3.41562021
13	Mitochondrial inheritance (HP:0001427)	3.26541501
14	Elevated erythrocyte sedimentation rate (HP:0003565)	3.26371298
15	Absent/shortened dynein arms (HP:0200106)	3.22667528
16	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.22667528
17	Renal cortical cysts (HP:0000803)	3.04161494
18	Ulnar claw (HP:0001178)	3.03702505
19	Increased CSF lactate (HP:0002490)	2.90229211
20	Volvulus (HP:0002580)	2.87066410
21	Constricted visual fields (HP:0001133)	2.77287271
22	Anencephaly (HP:0002323)	2.73403278
23	Abnormality of the renal collecting system (HP:0004742)	2.71222314
24	Medial flaring of the eyebrow (HP:0010747)	2.63250724
25	Hypoplasia of the pons (HP:0012110)	2.58244405
26	Duplicated collecting system (HP:0000081)	2.54369368
27	Abnormality of the pons (HP:0007361)	2.54175362
28	Cystic liver disease (HP:0006706)	2.52725743
29	Polyphagia (HP:0002591)	2.52097123
30	Molar tooth sign on MRI (HP:0002419)	2.51274341
31	Abnormality of midbrain morphology (HP:0002418)	2.51274341
32	Abnormality of the renal cortex (HP:0011035)	2.46979923
33	Amniotic constriction ring (HP:0009775)	2.42219512
34	Abnormality of placental membranes (HP:0011409)	2.42219512
35	Optic disc pallor (HP:0000543)	2.40993214
36	Nephrogenic diabetes insipidus (HP:0009806)	2.40279895
37	Type I transferrin isoform profile (HP:0003642)	2.38885206
38	Hepatocellular necrosis (HP:0001404)	2.38392921
39	Hepatic necrosis (HP:0002605)	2.35660313
40	Nephronophthisis (HP:0000090)	2.32985190
41	Congenital hepatic fibrosis (HP:0002612)	2.29581004
42	Increased serum lactate (HP:0002151)	2.27767953
43	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.27189265
44	Gait imbalance (HP:0002141)	2.23993879
45	Optic neuritis (HP:0100653)	2.23051101
46	Retrobulbar optic neuritis (HP:0100654)	2.23051101
47	Chronic bronchitis (HP:0004469)	2.20645791
48	Abnormality of the renal medulla (HP:0100957)	2.18002860
49	Acute lymphatic leukemia (HP:0006721)	2.16899486
50	Abnormality of lateral ventricle (HP:0030047)	2.16532226
51	Postaxial foot polydactyly (HP:0001830)	2.16114801
52	Abnormal ciliary motility (HP:0012262)	2.14548270
53	Congenital primary aphakia (HP:0007707)	2.13994620
54	Male pseudohermaphroditism (HP:0000037)	2.13875296
55	Abnormal respiratory epithelium morphology (HP:0012253)	2.13083640
56	Abnormal respiratory motile cilium morphology (HP:0005938)	2.13083640
57	Long foot (HP:0001833)	2.13058335
58	Occipital encephalocele (HP:0002085)	2.10057333
59	Abnormality of the anterior horn cell (HP:0006802)	2.09169080
60	Degeneration of anterior horn cells (HP:0002398)	2.09169080
61	Genital tract atresia (HP:0001827)	2.06616793
62	Lactic acidosis (HP:0003128)	2.06488009
63	Febrile seizures (HP:0002373)	2.06199542
64	Microvesicular hepatic steatosis (HP:0001414)	2.05491410
65	Increased serum pyruvate (HP:0003542)	2.03919680
66	Abnormal protein N-linked glycosylation (HP:0012347)	2.01917589
67	Abnormal protein glycosylation (HP:0012346)	2.01917589
68	Abnormal glycosylation (HP:0012345)	2.01917589
69	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.01917589
70	Renal Fanconi syndrome (HP:0001994)	2.01912900
71	Adactyly (HP:0009776)	2.00063418
72	Type 2 muscle fiber atrophy (HP:0003554)	1.98420965
73	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.97706859
74	Aplastic anemia (HP:0001915)	1.95904002
75	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.91525377
76	Lethargy (HP:0001254)	1.89258885
77	Bile duct proliferation (HP:0001408)	1.89057508
78	Abnormal biliary tract physiology (HP:0012439)	1.89057508
79	Respiratory failure (HP:0002878)	1.86201127
80	Metaphyseal dysplasia (HP:0100255)	1.84318190
81	Leukodystrophy (HP:0002415)	1.83368771
82	Abnormality of alanine metabolism (HP:0010916)	1.83180509
83	Hyperalaninemia (HP:0003348)	1.83180509
84	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.83180509
85	Vaginal atresia (HP:0000148)	1.81323394
86	Hyperglycinuria (HP:0003108)	1.80872217
87	Segmental peripheral demyelination/remyelination (HP:0003481)	1.78925427
88	Opisthotonus (HP:0002179)	1.77393718
89	Pulmonary artery stenosis (HP:0004415)	1.75873182
90	Proximal tubulopathy (HP:0000114)	1.74967571
91	Severe visual impairment (HP:0001141)	1.73466239
92	Poor coordination (HP:0002370)	1.72857187
93	Sclerocornea (HP:0000647)	1.72739568
94	Exercise intolerance (HP:0003546)	1.71896321
95	Abnormal respiratory motile cilium physiology (HP:0012261)	1.71236533
96	Epidermoid cyst (HP:0200040)	1.69904183
97	Reticulocytopenia (HP:0001896)	1.68937792
98	Abnormality of renal resorption (HP:0011038)	1.68719251
99	Abnormal number of erythroid precursors (HP:0012131)	1.68358428
100	Orchitis (HP:0100796)	1.66726971

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NEK1	4.76690630
2	TAOK3	4.28010018
3	NUAK1	2.74965157
4	WNK4	2.74307665
5	MAP3K12	2.65673952
6	MST4	2.61857275
7	WNK3	2.55875861
8	TXK	2.41524601
9	MAP4K2	2.33314833
10	MAPK13	2.30339378
11	PINK1	2.01540242
12	BCR	1.97029145
13	EIF2AK3	1.87371060
14	BCKDK	1.80403636
15	ADRBK2	1.80319165
16	STK39	1.69795457
17	GRK7	1.66707560
18	SRPK1	1.63355098
19	TNIK	1.60097225
20	NEK2	1.54397880
21	EIF2AK1	1.54352387
22	OXSR1	1.54102046
23	EPHA4	1.41859086
24	DYRK2	1.33393755
25	EPHB1	1.32778456
26	MAP2K7	1.21879088
27	TRIM28	1.17458165
28	TAOK1	1.14427196
29	MARK1	1.10644020
30	FRK	1.10481086
31	MAP3K4	1.09000690
32	MINK1	1.07935694
33	MST1R	1.05531011
34	PAK3	1.05039104
35	PBK	1.01545452
36	PLK4	1.01532453
37	MKNK2	0.91171905
38	EPHA3	0.90917966
39	PDK2	0.89988595
40	TLK1	0.87158745
41	TGFBR2	0.84736326
42	IRAK1	0.84640445
43	LMTK2	0.83377969
44	ROCK2	0.77742168
45	ERBB3	0.77076099
46	CASK	0.74493784
47	PIM2	0.72011017
48	ZAK	0.71732041
49	GRK1	0.70170726
50	INSRR	0.67376315
51	TEC	0.66090674
52	MYLK	0.63781291
53	MAPK15	0.62458729
54	BLK	0.57723355
55	DAPK1	0.55945872
56	MET	0.55358507
57	PHKG1	0.55093377
58	PHKG2	0.55093377
59	CAMK2A	0.54167430
60	PKN1	0.51842863
61	PRKCE	0.51519846
62	MAPK4	0.51224673
63	BUB1	0.51119094
64	DYRK3	0.50979492
65	ADRBK1	0.49866588
66	MKNK1	0.49121114
67	PRKG2	0.48964352
68	PRKG1	0.47568467
69	CAMKK2	0.47460060
70	MUSK	0.47174863
71	AKT2	0.46890082
72	CSNK1E	0.46297930
73	CSNK2A2	0.45930519
74	TIE1	0.45703781
75	TBK1	0.44820511
76	CSNK1A1	0.44603530
77	WNK1	0.44110183
78	TYK2	0.43456999
79	CDK3	0.42331153
80	KIT	0.42306288
81	ILK	0.42204300
82	PRKACA	0.41849941
83	PRKCG	0.41783274
84	PRKCD	0.41523711
85	BRD4	0.40981114
86	CSNK1G2	0.40728186
87	BMPR1B	0.40696442
88	CSNK1G3	0.39734202
89	PIK3CG	0.38907582
90	PRKACB	0.38808402
91	DMPK	0.37471037
92	RPS6KA4	0.37238262
93	IRAK3	0.31696827
94	STK3	0.31409310
95	ACVR1B	0.29658955
96	VRK1	0.28912923
97	NME2	0.28461487
98	CAMK2B	0.28043854
99	TGFBR1	0.27998012
100	TSSK6	0.27853357

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.65436648
2	Parkinsons disease_Homo sapiens_hsa05012	3.20046364
3	Basal transcription factors_Homo sapiens_hsa03022	2.61187859
4	Ribosome_Homo sapiens_hsa03010	2.60791596
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.58668284
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.55311895
7	Protein export_Homo sapiens_hsa03060	2.55157555
8	Huntingtons disease_Homo sapiens_hsa05016	2.52140953
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.46938841
10	Alzheimers disease_Homo sapiens_hsa05010	2.37095652
11	Sulfur relay system_Homo sapiens_hsa04122	2.26323791
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.15683867
13	RNA polymerase_Homo sapiens_hsa03020	2.00342760
14	Steroid biosynthesis_Homo sapiens_hsa00100	1.97528833
15	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.87506061
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.86423012
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.83862888
18	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.82352187
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.73206111
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.71903709
21	Non-homologous end-joining_Homo sapiens_hsa03450	1.66761237
22	Phototransduction_Homo sapiens_hsa04744	1.64749350
23	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.62445867
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.58658291
25	Taste transduction_Homo sapiens_hsa04742	1.53835881
26	Propanoate metabolism_Homo sapiens_hsa00640	1.53547974
27	Proteasome_Homo sapiens_hsa03050	1.42516638
28	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.38301340
29	One carbon pool by folate_Homo sapiens_hsa00670	1.35858029
30	Nitrogen metabolism_Homo sapiens_hsa00910	1.35226607
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.35185658
32	Olfactory transduction_Homo sapiens_hsa04740	1.34030766
33	Sulfur metabolism_Homo sapiens_hsa00920	1.28868476
34	Homologous recombination_Homo sapiens_hsa03440	1.26650647
35	Butanoate metabolism_Homo sapiens_hsa00650	1.25996738
36	Cardiac muscle contraction_Homo sapiens_hsa04260	1.25748628
37	Ether lipid metabolism_Homo sapiens_hsa00565	1.25578387
38	RNA degradation_Homo sapiens_hsa03018	1.21048340
39	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.19961621
40	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.14926352
41	RNA transport_Homo sapiens_hsa03013	1.14921482
42	Pyrimidine metabolism_Homo sapiens_hsa00240	1.12609285
43	Base excision repair_Homo sapiens_hsa03410	1.12256343
44	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.05508488
45	Asthma_Homo sapiens_hsa05310	1.05099017
46	Glutathione metabolism_Homo sapiens_hsa00480	1.04726665
47	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.00814862
48	Nicotine addiction_Homo sapiens_hsa05033	0.99566298
49	Tryptophan metabolism_Homo sapiens_hsa00380	0.99094287
50	Allograft rejection_Homo sapiens_hsa05330	0.98921764
51	Nucleotide excision repair_Homo sapiens_hsa03420	0.97086795
52	Regulation of autophagy_Homo sapiens_hsa04140	0.97078494
53	Purine metabolism_Homo sapiens_hsa00230	0.91654431
54	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.81140340
55	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.80300967
56	Metabolic pathways_Homo sapiens_hsa01100	0.78243054
57	Fat digestion and absorption_Homo sapiens_hsa04975	0.72228480
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.71645353
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.70911382
60	Glutamatergic synapse_Homo sapiens_hsa04724	0.68333534
61	Type I diabetes mellitus_Homo sapiens_hsa04940	0.67847932
62	Graft-versus-host disease_Homo sapiens_hsa05332	0.66714273
63	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.66188961
64	Rheumatoid arthritis_Homo sapiens_hsa05323	0.64932230
65	Retinol metabolism_Homo sapiens_hsa00830	0.64674666
66	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.64410826
67	Folate biosynthesis_Homo sapiens_hsa00790	0.63758720
68	Peroxisome_Homo sapiens_hsa04146	0.62038557
69	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.61385719
70	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.59190149
71	Serotonergic synapse_Homo sapiens_hsa04726	0.59005611
72	Salivary secretion_Homo sapiens_hsa04970	0.56900408
73	African trypanosomiasis_Homo sapiens_hsa05143	0.56475764
74	Circadian entrainment_Homo sapiens_hsa04713	0.56284393
75	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.56138291
76	Collecting duct acid secretion_Homo sapiens_hsa04966	0.55345869
77	Spliceosome_Homo sapiens_hsa03040	0.55189468
78	Mismatch repair_Homo sapiens_hsa03430	0.54844413
79	Chemical carcinogenesis_Homo sapiens_hsa05204	0.54504561
80	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.53795829
81	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.51658039
82	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.51205411
83	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.50067046
84	Pyruvate metabolism_Homo sapiens_hsa00620	0.49542538
85	Oocyte meiosis_Homo sapiens_hsa04114	0.49497303
86	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.48889185
87	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.43854679
88	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.41428176
89	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.41224227
90	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40407411
91	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.39793527
92	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.39780161
93	Long-term depression_Homo sapiens_hsa04730	0.38332017
94	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.37063442
95	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.36086114
96	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.34540419
97	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.34187486
98	GABAergic synapse_Homo sapiens_hsa04727	0.31572164
99	Renin secretion_Homo sapiens_hsa04924	0.30842457
100	Pancreatic secretion_Homo sapiens_hsa04972	0.30700422

PMS2P9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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