PMVK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a peroxisomal enzyme that is a member of the galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase (GHMP) family of ATP-dependent enzymes. The encoded protein catalyzes the conversion of mevalonate 5-phosphate to mevalonate 5-diphosphate, which is the fifth step in the mevalonate pathway of isoprenoid biosynthesis. Mutations in this gene are linked to certain types of porokeratosis including disseminated superficial porokeratosis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)8.21753198
2axon ensheathment in central nervous system (GO:0032291)6.96798162
3central nervous system myelination (GO:0022010)6.96798162
4* cholesterol biosynthetic process (GO:0006695)6.96724515
5* sterol biosynthetic process (GO:0016126)6.11093814
6long-chain fatty acid biosynthetic process (GO:0042759)5.68976086
7deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.59854916
8isoprenoid biosynthetic process (GO:0008299)5.35979282
9long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)5.01551416
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.86632223
11long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.77764034
12ATP synthesis coupled proton transport (GO:0015986)4.74654750
13energy coupled proton transport, down electrochemical gradient (GO:0015985)4.74654750
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.73633477
15pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.65712776
16fatty-acyl-CoA biosynthetic process (GO:0046949)4.53683124
17fatty-acyl-CoA metabolic process (GO:0035337)4.39988565
18protein neddylation (GO:0045116)4.17932591
19myelination (GO:0042552)4.08314452
20glycerophospholipid catabolic process (GO:0046475)4.07066689
21ensheathment of neurons (GO:0007272)4.05548140
22axon ensheathment (GO:0008366)4.05548140
23deoxyribose phosphate biosynthetic process (GO:0046385)4.04579821
242-deoxyribonucleotide biosynthetic process (GO:0009265)4.04579821
25chaperone-mediated protein transport (GO:0072321)4.03497270
26respiratory electron transport chain (GO:0022904)4.02634704
27electron transport chain (GO:0022900)3.92843058
28thioester biosynthetic process (GO:0035384)3.90662763
29acyl-CoA biosynthetic process (GO:0071616)3.90662763
30erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.90606868
31L-phenylalanine catabolic process (GO:0006559)3.90606868
32pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.88156071
33substantia nigra development (GO:0021762)3.86263320
34protein maturation by protein folding (GO:0022417)3.83153473
35NADH metabolic process (GO:0006734)3.79572936
36negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.76145016
37fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.72824714
38amyloid precursor protein metabolic process (GO:0042982)3.68875089
39pyrimidine nucleotide catabolic process (GO:0006244)3.58145251
40deoxyribonucleotide catabolic process (GO:0009264)3.54092217
41oxidative phosphorylation (GO:0006119)3.53726310
42base-excision repair, AP site formation (GO:0006285)3.50278028
43very long-chain fatty acid metabolic process (GO:0000038)3.48210392
44L-phenylalanine metabolic process (GO:0006558)3.44749555
45erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.44749555
46amyloid precursor protein catabolic process (GO:0042987)3.44083806
47negative regulation of neurotransmitter transport (GO:0051589)3.39786201
48protein insertion into membrane (GO:0051205)3.38210406
49regulation of collateral sprouting (GO:0048670)3.33649111
50metallo-sulfur cluster assembly (GO:0031163)3.30846288
51iron-sulfur cluster assembly (GO:0016226)3.30846288
52mitochondrial calcium ion transport (GO:0006851)3.28658819
53deoxyribose phosphate catabolic process (GO:0046386)3.28342451
54mitotic nuclear envelope reassembly (GO:0007084)3.27766858
55nuclear envelope reassembly (GO:0031468)3.27766858
56glyoxylate metabolic process (GO:0046487)3.21284898
57aldehyde catabolic process (GO:0046185)3.19910032
58* acyl-CoA metabolic process (GO:0006637)3.18649590
59* thioester metabolic process (GO:0035383)3.18649590
60proline biosynthetic process (GO:0006561)3.17903330
61deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.17457141
622-deoxyribonucleotide metabolic process (GO:0009394)3.17071816
63negative regulation of neurotransmitter secretion (GO:0046929)3.15405400
64negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.10899313
65GDP-mannose metabolic process (GO:0019673)3.10005365
66energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.08973412
67ATP hydrolysis coupled proton transport (GO:0015991)3.08973412
68oligodendrocyte differentiation (GO:0048709)3.02884306
69* steroid biosynthetic process (GO:0006694)3.02525002
70nucleotide salvage (GO:0043173)3.01565514
71response to redox state (GO:0051775)2.99035152
72polyketide metabolic process (GO:0030638)2.96804095
73doxorubicin metabolic process (GO:0044598)2.96804095
74daunorubicin metabolic process (GO:0044597)2.96804095
75protein retention in ER lumen (GO:0006621)2.94967605
76deoxyribose phosphate metabolic process (GO:0019692)2.93788010
77coenzyme catabolic process (GO:0009109)2.93256665
78purine nucleotide salvage (GO:0032261)2.92442331
79cofactor catabolic process (GO:0051187)2.91890863
80nucleotide transmembrane transport (GO:1901679)2.90562000
81positive regulation of mitochondrial fission (GO:0090141)2.90097683
82purine deoxyribonucleotide catabolic process (GO:0009155)2.88939856
83response to methylmercury (GO:0051597)2.86156553
84protein targeting to mitochondrion (GO:0006626)2.84984077
85* alcohol biosynthetic process (GO:0046165)2.84400503
86UV protection (GO:0009650)2.84391962
87positive regulation of cellular amine metabolic process (GO:0033240)2.83602183
88regulation of mitochondrial translation (GO:0070129)2.83243883
89glutathione biosynthetic process (GO:0006750)2.81872624
90prostaglandin biosynthetic process (GO:0001516)2.80956925
91prostanoid biosynthetic process (GO:0046457)2.80956925
92neuron cell-cell adhesion (GO:0007158)2.79838429
93regulation of autophagic vacuole assembly (GO:2000785)2.79630320
94* cholesterol metabolic process (GO:0008203)2.79486092
95response to lipoprotein particle (GO:0055094)2.78950850
96establishment of protein localization to mitochondrial membrane (GO:0090151)2.78240293
97aerobic respiration (GO:0009060)2.77966734
98establishment of mitochondrion localization (GO:0051654)2.77057232
99response to misfolded protein (GO:0051788)2.76838163
100pentose-phosphate shunt (GO:0006098)2.76481510
101establishment of protein localization to mitochondrion (GO:0072655)2.75756903
102peroxisome fission (GO:0016559)2.74603886
103pentose metabolic process (GO:0019321)2.70888923
104negative regulation of B cell apoptotic process (GO:0002903)2.69385211
105presynaptic membrane assembly (GO:0097105)2.68884627
106regulation of activation of Janus kinase activity (GO:0010533)2.68841015
107regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.68760555
108oxaloacetate metabolic process (GO:0006107)2.68760255
109terpenoid biosynthetic process (GO:0016114)2.67661817
110autophagic vacuole fusion (GO:0000046)2.66829276
111mitochondrial respiratory chain complex I assembly (GO:0032981)2.66596429
112NADH dehydrogenase complex assembly (GO:0010257)2.66596429
113mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.66596429
114presynaptic membrane organization (GO:0097090)2.65992805
115aromatic amino acid family catabolic process (GO:0009074)2.65714444
116glucose catabolic process (GO:0006007)2.64993606
117deoxyribonucleotide biosynthetic process (GO:0009263)2.62468987
118proline metabolic process (GO:0006560)2.61478367
119deoxyribonucleotide metabolic process (GO:0009262)2.61103772
120viral protein processing (GO:0019082)2.61027043
121negative regulation of cell size (GO:0045792)2.60589330
122hydrogen ion transmembrane transport (GO:1902600)2.60358612
123negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.60151711
124purine deoxyribonucleotide metabolic process (GO:0009151)2.59315858
125creatine metabolic process (GO:0006600)2.58841041
126gluconeogenesis (GO:0006094)2.58266909
127alkaloid metabolic process (GO:0009820)2.58044562
128COPI coating of Golgi vesicle (GO:0048205)2.57197065
129Golgi transport vesicle coating (GO:0048200)2.57197065
130protein complex biogenesis (GO:0070271)2.57085008
131* sterol metabolic process (GO:0016125)2.56451635
132branched-chain amino acid catabolic process (GO:0009083)2.56268976
133aminoglycoside antibiotic metabolic process (GO:0030647)2.55491087
134neural nucleus development (GO:0048857)2.55433671
135positive regulation of TOR signaling (GO:0032008)2.55418506
136ribosomal small subunit biogenesis (GO:0042274)2.55252018
137maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.55002679
138pyrimidine nucleobase catabolic process (GO:0006208)2.54851236
139mitochondrial respiratory chain complex assembly (GO:0033108)2.54039720
140negative regulation of protein localization to cell surface (GO:2000009)2.53996056
141protein localization to mitochondrion (GO:0070585)2.53816420
142mitochondrial fusion (GO:0008053)2.52738408
143nonribosomal peptide biosynthetic process (GO:0019184)2.51903092
144mannosylation (GO:0097502)2.51740660
145regulation of vacuole organization (GO:0044088)2.51704871
146peripheral nervous system development (GO:0007422)2.51391875
147fatty acid beta-oxidation (GO:0006635)2.51117363
148myelin maintenance (GO:0043217)2.51109948
149proton transport (GO:0015992)2.49828700
150monosaccharide biosynthetic process (GO:0046364)2.49722131
151regulation of release of cytochrome c from mitochondria (GO:0090199)2.49570067
152transmission of nerve impulse (GO:0019226)2.49308629
153nucleoside diphosphate biosynthetic process (GO:0009133)2.46861411
154water-soluble vitamin biosynthetic process (GO:0042364)2.46575365
155positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.46130199
156pyrimidine-containing compound transmembrane transport (GO:0072531)2.46013978
157regulation of cholesterol esterification (GO:0010872)2.45715580
158eye photoreceptor cell differentiation (GO:0001754)2.45497809
159photoreceptor cell differentiation (GO:0046530)2.45497809
160hydrogen transport (GO:0006818)2.45298037
161positive regulation of actin filament depolymerization (GO:0030836)2.45143648
162tyrosine metabolic process (GO:0006570)2.45051461
163positive regulation of prostaglandin secretion (GO:0032308)2.44180672
164peptidyl-arginine omega-N-methylation (GO:0035247)2.44171982
165purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.44132945
166pyrimidine nucleoside salvage (GO:0043097)2.43342903
167pyrimidine-containing compound salvage (GO:0008655)2.43342903
168detection of temperature stimulus involved in sensory perception (GO:0050961)2.43265721
169detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.43265721
170virion attachment to host cell (GO:0019062)2.43180529
171adhesion of symbiont to host cell (GO:0044650)2.43180529
172purine nucleoside diphosphate metabolic process (GO:0009135)2.42883926
173regulation of catecholamine metabolic process (GO:0042069)2.42143077
174regulation of dopamine metabolic process (GO:0042053)2.42143077
175heme transport (GO:0015886)2.41562787
176dopamine biosynthetic process (GO:0042416)2.41369234
177glutathione metabolic process (GO:0006749)2.41364951
178triglyceride biosynthetic process (GO:0019432)2.41024993
179fatty acid biosynthetic process (GO:0006633)2.39619084
180coenzyme A metabolic process (GO:0015936)2.39195432
181estrogen biosynthetic process (GO:0006703)2.39091759
182iron coordination entity transport (GO:1901678)2.38822610
183ATP biosynthetic process (GO:0006754)2.37857281
184proteasome assembly (GO:0043248)2.36605489

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.76884964
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.03495890
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.56418483
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.21088047
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.10581537
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.91423533
7TAF15_26573619_Chip-Seq_HEK293_Human2.74884736
8GBX2_23144817_ChIP-Seq_PC3_Human2.59576937
9LXR_22292898_ChIP-Seq_THP-1_Human2.28164668
10SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.24217052
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.20671334
12VDR_21846776_ChIP-Seq_THP-1_Human2.19817392
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.19219198
14SRY_22984422_ChIP-ChIP_TESTIS_Rat2.17931599
15THAP11_20581084_ChIP-Seq_MESCs_Mouse2.15879811
16CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.07209237
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.06242506
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.03332555
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.02759094
20ETS1_20019798_ChIP-Seq_JURKAT_Human1.98672366
21* TET1_21451524_ChIP-Seq_MESCs_Mouse1.98444393
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.96412807
23CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.92919198
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.90821960
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.90749552
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88678196
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.87667175
28CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.87570789
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.86100606
30MYC_18555785_ChIP-Seq_MESCs_Mouse1.85328401
31VDR_22108803_ChIP-Seq_LS180_Human1.85159688
32SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.78622867
33XRN2_22483619_ChIP-Seq_HELA_Human1.77038178
34EZH2_22144423_ChIP-Seq_EOC_Human1.76778563
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.76307753
36P68_20966046_ChIP-Seq_HELA_Human1.75669855
37ELF1_20517297_ChIP-Seq_JURKAT_Human1.75273518
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.74873807
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.72339520
40BCL6_27268052_Chip-Seq_Bcells_Human1.69977081
41ER_23166858_ChIP-Seq_MCF-7_Human1.67047661
42ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.66993620
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.65930050
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.65423851
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64805846
46GABP_19822575_ChIP-Seq_HepG2_Human1.63809363
47SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.63632214
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.62553034
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.62241834
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61801784
51SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.58589760
52SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.58101517
53CTCF_18555785_ChIP-Seq_MESCs_Mouse1.56022364
54* HTT_18923047_ChIP-ChIP_STHdh_Human1.55854133
55SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.53289110
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.52290587
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49753607
58SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.49559633
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48658113
60BCOR_27268052_Chip-Seq_Bcells_Human1.47915183
61SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.47538182
62* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.46398455
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46078633
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.45717846
65EZH2_27294783_Chip-Seq_ESCs_Mouse1.45633290
66SUZ12_27294783_Chip-Seq_ESCs_Mouse1.45611759
67P300_19829295_ChIP-Seq_ESCs_Human1.44674219
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44350026
69* SA1_27219007_Chip-Seq_ERYTHROID_Human1.44295182
70MTF2_20144788_ChIP-Seq_MESCs_Mouse1.44147271
71NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.43542281
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43347212
73* RACK7_27058665_Chip-Seq_MCF-7_Human1.42955878
74EZH2_18974828_ChIP-Seq_MESCs_Mouse1.42840359
75RNF2_18974828_ChIP-Seq_MESCs_Mouse1.42840359
76* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42837439
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42328740
78BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.41154660
79KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.39628214
80SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37924882
81RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36737637
82CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.36705635
83CTCF_26484167_Chip-Seq_Bcells_Mouse1.35220141
84GABP_17652178_ChIP-ChIP_JURKAT_Human1.34524551
85* ELK3_25401928_ChIP-Seq_HUVEC_Human1.32159819
86HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30642277
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30538902
88RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28916396
89* SA1_27219007_Chip-Seq_Bcells_Human1.28432630
90MYC_19030024_ChIP-ChIP_MESCs_Mouse1.28146595
91* YY1_22570637_ChIP-Seq_MALME-3M_Human1.27777486
92FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.27269874
93PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.27123909
94REST_21632747_ChIP-Seq_MESCs_Mouse1.27072965
95SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26675885
96FOXP1_21924763_ChIP-Seq_HESCs_Human1.26514373
97PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25890658
98CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25847349
99TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24937389
100PU.1_20513432_ChIP-Seq_Bcells_Mouse1.24053518
101IRF1_19129219_ChIP-ChIP_H3396_Human1.23711695
102ZNF263_19887448_ChIP-Seq_K562_Human1.23478983
103DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22735517
104SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.22627623
105GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21560942
106CTCF_20526341_ChIP-Seq_ESCs_Human1.21362868
107* SMC4_20622854_ChIP-Seq_HELA_Human1.21346841
108* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21322828
109DCP1A_22483619_ChIP-Seq_HELA_Human1.20037439
110KDM5A_27292631_Chip-Seq_BREAST_Human1.19694413
111MYC_19079543_ChIP-ChIP_MESCs_Mouse1.19117755
112REST_18959480_ChIP-ChIP_MESCs_Mouse1.18353856
113MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.17719009
114AR_21572438_ChIP-Seq_LNCaP_Human1.17010002
115* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16714589
116RXR_22158963_ChIP-Seq_LIVER_Mouse1.16387529
117MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.16049791
118MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15925563
119NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15114325
120* E2F1_20622854_ChIP-Seq_HELA_Human1.14610016
121* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.14337039
122FUS_26573619_Chip-Seq_HEK293_Human1.13611302
123* MYC_22102868_ChIP-Seq_BL_Human1.12973633
124CIITA_25753668_ChIP-Seq_RAJI_Human1.12177575
125PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11240443
126PHF8_20622854_ChIP-Seq_HELA_Human1.11084281
127CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10678046
128NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09992173
129UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09550449
130IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09346803
131SMAD3_21741376_ChIP-Seq_EPCs_Human1.09298706
132* CTCF_27219007_Chip-Seq_Bcells_Human1.09293607
133ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08964803
134* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.08581579
135SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.08495453
136PPARA_22158963_ChIP-Seq_LIVER_Mouse1.07170991
137PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07079010
138CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06803214
139TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06724090
140* RARB_24833708_ChIP-Seq_LIVER_Mouse1.06627995
141NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05944101
142NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05944101
143* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05797442
144SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04433274
145TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03338169
146RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03174969
147TTF2_22483619_ChIP-Seq_HELA_Human1.02442112
148OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02243588
149* CTCF_21964334_Chip-Seq_Bcells_Human1.01992224
150PIAS1_25552417_ChIP-Seq_VCAP_Human1.00968383
151* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00505665
152RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00339215
153FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99349398
154TAL1_26923725_Chip-Seq_HPCs_Mouse0.99149374
155WT1_19549856_ChIP-ChIP_CCG9911_Human0.99136283
156* CREB1_15753290_ChIP-ChIP_HEK293T_Human0.98037772
157LXR_22158963_ChIP-Seq_LIVER_Mouse0.97657739
158RNF2_27304074_Chip-Seq_ESCs_Mouse0.97524599
159JUN_21703547_ChIP-Seq_K562_Human0.96674059
160SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95860402
161CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.93929878
162STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93481525
163NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93368125
164NCOR_22424771_ChIP-Seq_293T_Human0.92844020
165EOMES_21245162_ChIP-Seq_HESCs_Human0.92567599
166CMYC_18555785_Chip-Seq_ESCs_Mouse0.92373401
167SOX2_19829295_ChIP-Seq_ESCs_Human0.91873668
168NANOG_19829295_ChIP-Seq_ESCs_Human0.91873668
169MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91845843
170PRDM14_20953172_ChIP-Seq_ESCs_Human0.91416495
171SRF_21415370_ChIP-Seq_HL-1_Mouse0.90818512
172ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90003116
173PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89797751
174SUZ12_18555785_Chip-Seq_ESCs_Mouse0.89650192
175NANOG_18555785_Chip-Seq_ESCs_Mouse0.88715826
176RNF2_27304074_Chip-Seq_NSC_Mouse0.86993047
177EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86813858
178RUNX1_27457419_Chip-Seq_LIVER_Mouse0.86502589
179EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.85810706
180EST1_17652178_ChIP-ChIP_JURKAT_Human0.85595953
181P300_18555785_Chip-Seq_ESCs_Mouse0.84040675
182FOXA1_21572438_ChIP-Seq_LNCaP_Human0.83180595
183JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.82107654
184ERG_21242973_ChIP-ChIP_JURKAT_Human0.81796689

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.81789298
2MP0000920_abnormal_myelination3.49623809
3MP0003880_abnormal_central_pattern3.25232455
4MP0003806_abnormal_nucleotide_metabolis3.24575158
5MP0001529_abnormal_vocalization3.24433093
6MP0001905_abnormal_dopamine_level3.14167745
7MP0003191_abnormal_cellular_cholesterol2.96888107
8MP0002139_abnormal_hepatobiliary_system2.84087342
9MP0002653_abnormal_ependyma_morphology2.65819388
10MP0004270_analgesia2.45494196
11MP0005451_abnormal_body_composition2.42891307
12MP0004142_abnormal_muscle_tone2.29862048
13MP0003690_abnormal_glial_cell2.29046132
14MP0006276_abnormal_autonomic_nervous2.18907217
15MP0005360_urolithiasis2.09183009
16MP0002272_abnormal_nervous_system2.04635550
17MP0003329_amyloid_beta_deposits1.99510608
18MP0004742_abnormal_vestibular_system1.96768666
19MP0008875_abnormal_xenobiotic_pharmacok1.91393951
20MP0002064_seizures1.90849728
21MP0001968_abnormal_touch/_nociception1.88330952
22MP0003195_calcinosis1.88150491
23MP0008789_abnormal_olfactory_epithelium1.86990358
24MP0005083_abnormal_biliary_tract1.79644070
25MP0003136_yellow_coat_color1.79622839
26MP0002734_abnormal_mechanical_nocicepti1.78034546
27MP0005501_abnormal_skin_physiology1.77148490
28MP0005464_abnormal_platelet_physiology1.76846891
29MP0005423_abnormal_somatic_nervous1.74131679
30MP0002736_abnormal_nociception_after1.73433306
31MP0001486_abnormal_startle_reflex1.72843490
32MP0000778_abnormal_nervous_system1.72107125
33MP0005085_abnormal_gallbladder_physiolo1.71396358
34MP0009745_abnormal_behavioral_response1.67794809
35MP0003075_altered_response_to1.65982974
36MP0003634_abnormal_glial_cell1.64267407
37MP0003950_abnormal_plasma_membrane1.63065869
38MP0005408_hypopigmentation1.60916546
39MP0005171_absent_coat_pigmentation1.60682725
40MP0001440_abnormal_grooming_behavior1.58823268
41MP0003879_abnormal_hair_cell1.56701166
42MP0009046_muscle_twitch1.56600938
43MP0005499_abnormal_olfactory_system1.55832386
44MP0005394_taste/olfaction_phenotype1.55832386
45MP0002733_abnormal_thermal_nociception1.51999875
46MP0000751_myopathy1.50314511
47MP0001485_abnormal_pinna_reflex1.48435790
48MP0005670_abnormal_white_adipose1.47724212
49MP0002876_abnormal_thyroid_physiology1.47520547
50MP0003183_abnormal_peptide_metabolism1.47476549
51MP0003632_abnormal_nervous_system1.46302135
52MP0001970_abnormal_pain_threshold1.44420888
53MP0002229_neurodegeneration1.43792486
54MP0002572_abnormal_emotion/affect_behav1.43135122
55MP0002735_abnormal_chemical_nociception1.41656455
56MP0003635_abnormal_synaptic_transmissio1.38896652
57MP0003186_abnormal_redox_activity1.38269869
58MP0005645_abnormal_hypothalamus_physiol1.35395220
59MP0002163_abnormal_gland_morphology1.34115192
60MP0005551_abnormal_eye_electrophysiolog1.32561248
61MP0001986_abnormal_taste_sensitivity1.31647110
62MP0000343_altered_response_to1.30963518
63MP0004859_abnormal_synaptic_plasticity1.30754453
64MP0004924_abnormal_behavior1.30633904
65MP0005386_behavior/neurological_phenoty1.30633904
66MP0002837_dystrophic_cardiac_calcinosis1.30508655
67MP0005535_abnormal_body_temperature1.29811870
68MP0009840_abnormal_foam_cell1.29395629
69MP0001346_abnormal_lacrimal_gland1.28899613
70MP0000372_irregular_coat_pigmentation1.28876848
71MP0005379_endocrine/exocrine_gland_phen1.28250484
72MP0002148_abnormal_hypersensitivity_rea1.26046130
73MP0002822_catalepsy1.25815105
74MP0003011_delayed_dark_adaptation1.24699408
75MP0000681_abnormal_thyroid_gland1.24575350
76MP0004381_abnormal_hair_follicle1.24206992
77MP0002063_abnormal_learning/memory/cond1.23921126
78MP0000604_amyloidosis1.23225159
79MP0009278_abnormal_bone_marrow1.21418003
80MP0005332_abnormal_amino_acid1.20987427
81MP0003436_decreased_susceptibility_to1.20526344
82MP0002067_abnormal_sensory_capabilities1.20203097
83MP0004885_abnormal_endolymph1.20104578
84MP0008874_decreased_physiological_sensi1.19703120
85MP0000685_abnormal_immune_system1.17555420
86MP0002638_abnormal_pupillary_reflex1.13650163
87MP0005584_abnormal_enzyme/coenzyme_acti1.11480317
88MP0000750_abnormal_muscle_regeneration1.11097294
89MP0001984_abnormal_olfaction1.10953922
90MP0003718_maternal_effect1.10883243
91MP0003631_nervous_system_phenotype1.07719923
92MP0009379_abnormal_foot_pigmentation1.06820241
93MP0002882_abnormal_neuron_morphology1.06656307
94MP0005365_abnormal_bile_salt1.06007434
95MP0002066_abnormal_motor_capabilities/c1.05858053
96MP0000955_abnormal_spinal_cord1.05689594
97MP0001963_abnormal_hearing_physiology1.04894606
98MP0005666_abnormal_adipose_tissue1.04789595
99MP0002184_abnormal_innervation1.02900562
100MP0005165_increased_susceptibility_to1.02850630
101MP0005330_cardiomyopathy1.02542063
102MP0002090_abnormal_vision1.01993786
103MP0004858_abnormal_nervous_system1.01706378
104MP0002752_abnormal_somatic_nervous0.99490977
105MP0005410_abnormal_fertilization0.99095214
106MP0002118_abnormal_lipid_homeostasis0.98555490
107MP0001661_extended_life_span0.98170192
108MP0001501_abnormal_sleep_pattern0.96184311
109MP0006036_abnormal_mitochondrial_physio0.95345723
110MP0002295_abnormal_pulmonary_circulatio0.92656029
111MP0004782_abnormal_surfactant_physiolog0.92205420
112MP0002751_abnormal_autonomic_nervous0.92151733
113MP0000358_abnormal_cell_content/0.91992307
114MP0002971_abnormal_brown_adipose0.91475882
115MP0003172_abnormal_lysosome_physiology0.91301643
116MP0003638_abnormal_response/metabolism_0.91184517
117MP0000465_gastrointestinal_hemorrhage0.90658556
118MP0000747_muscle_weakness0.90249717
119MP0009643_abnormal_urine_homeostasis0.89668885
120MP0005025_abnormal_response_to0.89311562
121MP0005409_darkened_coat_color0.88894303
122MP0008260_abnormal_autophagy0.88254300
123MP0005253_abnormal_eye_physiology0.85544181
124MP0006035_abnormal_mitochondrial_morpho0.85208828
125MP0005319_abnormal_enzyme/_coenzyme0.84580305
126MP0001764_abnormal_homeostasis0.84176110
127MP0008569_lethality_at_weaning0.83808608
128MP0002557_abnormal_social/conspecific_i0.83801185
129MP0010386_abnormal_urinary_bladder0.83187461
130MP0001853_heart_inflammation0.81923687
131MP0000026_abnormal_inner_ear0.81432152
132MP0002796_impaired_skin_barrier0.79789656
133MP0009333_abnormal_splenocyte_physiolog0.78614701
134MP0004134_abnormal_chest_morphology0.78095073
135MP0000749_muscle_degeneration0.77016481
136MP0005195_abnormal_posterior_eye0.76240911
137MP0000566_synostosis0.76185562
138MP0001348_abnormal_lacrimal_gland0.75909501
139MP0001790_abnormal_immune_system0.75789997
140MP0005387_immune_system_phenotype0.75789997
141MP0001727_abnormal_embryo_implantation0.75021032
142MP0003656_abnormal_erythrocyte_physiolo0.73812101
143MP0003633_abnormal_nervous_system0.73689450
144MP0002970_abnormal_white_adipose0.71650502
145MP0005636_abnormal_mineral_homeostasis0.71484549
146MP0008058_abnormal_DNA_repair0.71435430
147MP0005084_abnormal_gallbladder_morpholo0.69388397
148MP0000678_abnormal_parathyroid_gland0.69334587
149MP0000759_abnormal_skeletal_muscle0.68564660
150MP0002078_abnormal_glucose_homeostasis0.68262840
151MP0009642_abnormal_blood_homeostasis0.68067016
152MP0005375_adipose_tissue_phenotype0.67736351
153MP0008469_abnormal_protein_level0.67428351
154MP0002138_abnormal_hepatobiliary_system0.66358395
155MP0002069_abnormal_eating/drinking_beha0.65759574
156MP0009764_decreased_sensitivity_to0.65375150
157MP0005452_abnormal_adipose_tissue0.64094933
158MP0005166_decreased_susceptibility_to0.63910296
159MP0005075_abnormal_melanosome_morpholog0.63687379
160MP0010771_integument_phenotype0.63473186

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)5.73873377
2Abnormality of glycolysis (HP:0004366)5.31936533
3Increased serum pyruvate (HP:0003542)5.31936533
4Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.77632062
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.72031172
6Degeneration of the lateral corticospinal tracts (HP:0002314)4.72031172
7Acute necrotizing encephalopathy (HP:0006965)4.56667953
8Neurofibrillary tangles (HP:0002185)4.35523589
9Congenital ichthyosiform erythroderma (HP:0007431)4.16313088
10Abnormal mitochondria in muscle tissue (HP:0008316)4.02561500
11Sensory axonal neuropathy (HP:0003390)3.99007448
12Acute encephalopathy (HP:0006846)3.95393002
13Mitochondrial inheritance (HP:0001427)3.84387443
14Progressive macrocephaly (HP:0004481)3.76088836
15Abnormality of the corticospinal tract (HP:0002492)3.75841078
16Leukodystrophy (HP:0002415)3.54782364
17Hepatocellular necrosis (HP:0001404)3.38056330
18Renal Fanconi syndrome (HP:0001994)3.36286584
19Ragged-red muscle fibers (HP:0003200)3.16215773
20Cerebral edema (HP:0002181)3.14100224
21Increased CSF lactate (HP:0002490)3.13530697
22Pheochromocytoma (HP:0002666)3.12983169
23Abnormality of aromatic amino acid family metabolism (HP:0004338)3.12885954
24Cerebral inclusion bodies (HP:0100314)3.12494656
25Dicarboxylic aciduria (HP:0003215)3.12294435
26Abnormality of dicarboxylic acid metabolism (HP:0010995)3.12294435
27Myokymia (HP:0002411)3.02514453
28Neuroendocrine neoplasm (HP:0100634)3.02149971
29Decreased activity of mitochondrial respiratory chain (HP:0008972)3.01459181
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.01459181
31Increased hepatocellular lipid droplets (HP:0006565)2.96432698
32Hepatic necrosis (HP:0002605)2.90689638
33Systemic lupus erythematosus (HP:0002725)2.88467149
34Cerebral palsy (HP:0100021)2.77910587
35Cerebral hemorrhage (HP:0001342)2.77576353
36Rhabdomyolysis (HP:0003201)2.76335008
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.75362759
38Abnormality of fatty-acid metabolism (HP:0004359)2.74036056
39Lipid accumulation in hepatocytes (HP:0006561)2.72236750
40Hypoplastic pelvis (HP:0008839)2.71868469
41Intrahepatic cholestasis (HP:0001406)2.68738436
42Hyperammonemia (HP:0001987)2.65326631
43Optic disc pallor (HP:0000543)2.62463034
443-Methylglutaconic aciduria (HP:0003535)2.60609302
45Spastic paraparesis (HP:0002313)2.58740354
46Cerebral hypomyelination (HP:0006808)2.58703646
47Retinal dysplasia (HP:0007973)2.57470605
48Peripheral hypomyelination (HP:0007182)2.57053290
49Dysostosis multiplex (HP:0000943)2.54181857
50Microvesicular hepatic steatosis (HP:0001414)2.53056833
51Abnormality of glycolipid metabolism (HP:0010969)2.51513389
52Abnormality of liposaccharide metabolism (HP:0010968)2.51513389
53Abnormality of glycosphingolipid metabolism (HP:0004343)2.51513389
54Agammaglobulinemia (HP:0004432)2.49422076
55Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.46860120
56Emotional lability (HP:0000712)2.45431894
57Cholecystitis (HP:0001082)2.43677191
58Abnormal gallbladder physiology (HP:0012438)2.43677191
59Methylmalonic acidemia (HP:0002912)2.40519676
60Distal lower limb muscle weakness (HP:0009053)2.40062184
61Hyperglycinemia (HP:0002154)2.39791470
62Anomalous pulmonary venous return (HP:0010772)2.39238462
63Supranuclear gaze palsy (HP:0000605)2.38610500
64Purpura (HP:0000979)2.38366642
65Opisthotonus (HP:0002179)2.37166571
66Autoamputation (HP:0001218)2.36778188
67Petechiae (HP:0000967)2.35734700
68Respiratory failure (HP:0002878)2.35702405
69Sensorimotor neuropathy (HP:0007141)2.35595231
70Loss of speech (HP:0002371)2.35091472
71Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.33186326
72Achilles tendon contracture (HP:0001771)2.32187460
73Akinesia (HP:0002304)2.31916154
74Spastic gait (HP:0002064)2.30775366
75Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.27754393
76Limb dystonia (HP:0002451)2.26846288
77Abnormality of the Achilles tendon (HP:0005109)2.26135516
78Growth hormone excess (HP:0000845)2.24850907
79Increased intramyocellular lipid droplets (HP:0012240)2.21987002
80Hypertensive crisis (HP:0100735)2.21192405
81Abnormality of renal resorption (HP:0011038)2.19207990
82Hypobetalipoproteinemia (HP:0003563)2.18830021
83Hypothermia (HP:0002045)2.16817246
84Erythroderma (HP:0001019)2.15911224
85Poor suck (HP:0002033)2.15545977
86Increased cerebral lipofuscin (HP:0011813)2.15207762
87Prolonged partial thromboplastin time (HP:0003645)2.13372446
88Myoglobinuria (HP:0002913)2.13299445
89Testicular atrophy (HP:0000029)2.12208657
90Myelomeningocele (HP:0002475)2.11375783
91Generalized aminoaciduria (HP:0002909)2.10971589
92Partial agenesis of the corpus callosum (HP:0001338)2.10742441
93Termporal pattern (HP:0011008)2.08380255
94Insidious onset (HP:0003587)2.08380255
95Lactic acidosis (HP:0003128)2.07106910
96Ketosis (HP:0001946)2.03716904
97Increased neuronal autofluorescent lipopigment (HP:0002074)2.03359626
98Polyphagia (HP:0002591)2.01785926
99Hypokinesia (HP:0002375)2.01515251
100Abnormality of the pulmonary veins (HP:0011718)2.01277268
101Increased serum lactate (HP:0002151)2.01262093
102Back pain (HP:0003418)2.00219060
103X-linked dominant inheritance (HP:0001423)1.99886308
104Vomiting (HP:0002013)1.99754321
105Amniotic constriction ring (HP:0009775)1.99498930
106Abnormality of placental membranes (HP:0011409)1.99498930
107Bulbar palsy (HP:0001283)1.99264350
108Vaginal atresia (HP:0000148)1.98990074
109Myopathic facies (HP:0002058)1.97899067
110Vertebral compression fractures (HP:0002953)1.97259744
111Microretrognathia (HP:0000308)1.96840200
112Abnormal hair whorl (HP:0010721)1.96825619
113Hyperlipoproteinemia (HP:0010980)1.95709368
114Aplasia/Hypoplasia of the sacrum (HP:0008517)1.94240034
115Exercise intolerance (HP:0003546)1.93663718
116Axonal loss (HP:0003447)1.93312344
117Fasciculations (HP:0002380)1.92042908
118Slow saccadic eye movements (HP:0000514)1.90900561
119Progressive neurologic deterioration (HP:0002344)1.90857275
120Neonatal onset (HP:0003623)1.89796223
121Genital tract atresia (HP:0001827)1.89589587
122Lethargy (HP:0001254)1.87535474
123Increased muscle lipid content (HP:0009058)1.87224077
124Hyperthyroidism (HP:0000836)1.87193823
125Progressive microcephaly (HP:0000253)1.86188797
126Exercise-induced myalgia (HP:0003738)1.85510656
127Diminished movement (HP:0002374)1.85350413
128Multiple enchondromatosis (HP:0005701)1.84375539
129Septate vagina (HP:0001153)1.84190776
130Morphological abnormality of the pyramidal tract (HP:0002062)1.81913125
131Vacuolated lymphocytes (HP:0001922)1.81894719
132Hypoplastic left heart (HP:0004383)1.81390107
133Exertional dyspnea (HP:0002875)1.80737985
134Increased IgE level (HP:0003212)1.80678764
135Muscle stiffness (HP:0003552)1.79941886
136Abnormality of polysaccharide metabolism (HP:0011012)1.79675577
137Abnormality of glycosaminoglycan metabolism (HP:0004371)1.79675577
138Abnormality of mucopolysaccharide metabolism (HP:0011020)1.79675577
139Stridor (HP:0010307)1.79310638
140Deep venous thrombosis (HP:0002625)1.79310571
141Xanthomatosis (HP:0000991)1.79062786
142Prolonged neonatal jaundice (HP:0006579)1.78995448
143Paraparesis (HP:0002385)1.78505000
144Broad distal phalanx of finger (HP:0009836)1.77533774
145Type I transferrin isoform profile (HP:0003642)1.77366496
146Intention tremor (HP:0002080)1.77221242
147Ankle clonus (HP:0011448)1.77194241
148Abnormal gallbladder morphology (HP:0012437)1.77105609
149Muscle fiber atrophy (HP:0100295)1.76567802
150CNS demyelination (HP:0007305)1.74610273
151Methylmalonic aciduria (HP:0012120)1.74460312
152Abnormality of the vitreous humor (HP:0004327)1.73255214
153Metabolic acidosis (HP:0001942)1.72103931
154Asymmetric septal hypertrophy (HP:0001670)1.71973775
155Atonic seizures (HP:0010819)1.71309750
156Centrally nucleated skeletal muscle fibers (HP:0003687)1.71145133
157Athetosis (HP:0002305)1.71004305
158Irregular epiphyses (HP:0010582)1.69756463
159Hepatosplenomegaly (HP:0001433)1.69397085
160Adrenal hypoplasia (HP:0000835)1.68425986
161Hypophosphatemic rickets (HP:0004912)1.67444425
162Glycosuria (HP:0003076)1.66699565
163Abnormality of urine glucose concentration (HP:0011016)1.66699565
164Hyperphosphaturia (HP:0003109)1.65031068
165Medial flaring of the eyebrow (HP:0010747)1.64917717
166Increased IgM level (HP:0003496)1.62884059

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.08439534
2VRK24.26669086
3BCR3.65711893
4PBK3.46806317
5OXSR13.28833373
6ERN13.27870357
7MAP3K113.13684819
8ARAF2.79530932
9CASK2.59919064
10LIMK12.58373711
11MST42.45594477
12EPHB12.31572831
13TNIK2.31484013
14WNK42.27597889
15PKN12.04261899
16CSNK1G32.00387819
17CDK191.88079808
18IRAK31.79600698
19BMPR1B1.74667607
20DYRK21.65230447
21NME11.64848379
22UHMK11.60491835
23MAPKAPK51.59708788
24PRPF4B1.54814888
25KDR1.49190262
26NEK11.46558223
27MARK11.46380148
28CSNK1A1L1.45726069
29MAP3K121.45564707
30TBK11.44756626
31GRK51.44227803
32CSNK1G11.42799699
33DAPK11.41139276
34FGR1.40947995
35MET1.40416742
36SMG11.40253737
37CSNK1G21.39615970
38NTRK11.39220294
39MAPKAPK31.38479072
40TESK21.35935720
41MAP4K11.29824775
42STK161.28810862
43SCYL21.28276027
44TAOK21.26732953
45TRIB31.24755234
46CCNB11.24542658
47PRKD31.22515073
48MAPK131.19508713
49LRRK21.13194888
50CAMK2B1.13072459
51TNK21.11750658
52PRKD21.09803396
53PNCK1.08571477
54ERBB41.06420934
55ADRBK21.02714435
56ROCK21.01246757
57AURKA1.00433695
58DYRK1B0.98136973
59LMTK20.97407706
60CAMK2G0.93287691
61PIM20.92661032
62PRKCE0.92014012
63SGK4940.91242703
64SGK2230.91242703
65NTRK20.91241400
66TAOK10.90577118
67BRAF0.89676089
68WNK10.88940500
69SIK10.88886319
70CAMK2D0.87536467
71NEK60.84348117
72CDK140.83528916
73CAMK2A0.83103137
74ABL20.80584192
75PRKCI0.79542741
76MAP2K70.79440826
77GRK70.79112195
78MAP4K20.77521735
79BCKDK0.76187977
80BMPR20.76108752
81NME20.75566338
82MARK20.75492728
83PRKCQ0.75283889
84ADRBK10.72722926
85BLK0.71575583
86FGFR20.70650106
87CDK50.68538775
88PLK20.68154569
89CDK180.67988531
90CDK150.67077249
91MAP3K90.65470581
92PAK30.62894356
93TLK10.61947434
94EPHA20.61380503
95MAP3K140.60644019
96CDK11A0.58622502
97ILK0.58408413
98SIK20.55118000
99TAOK30.55029515
100MAPK120.54821320
101AKT20.54542611
102PRKD10.54375659
103PAK60.54352092
104MINK10.53791465
105IRAK20.52853854
106PHKG20.51687576
107PHKG10.51687576
108MAP2K60.50897534
109MAP3K130.49826450
110MUSK0.48214339
111MAP2K40.48133125
112RPS6KA50.48110671
113MAP2K20.47867376
114PRKCG0.47341222
115PRKACA0.46785439
116DAPK20.46081502
117MAP3K50.46014745
118GRK10.44970785
119SRPK10.42554940
120EPHB20.42017370
121CDK80.41598275
122RAF10.40895692
123MYLK0.40492588
124KSR20.40168946
125CSF1R0.39003123
126OBSCN0.37977131
127ICK0.37227028
128BUB10.36804119
129PAK10.36271467
130TESK10.36088911
131PRKCZ0.35012363
132YES10.33972825
133PRKG20.33859150
134MAP3K10.33751924
135MAPK40.32500603
136DYRK1A0.32314458
137MAP3K40.31940243
138EPHA40.31426349
139MAP2K30.31402373
140PTK2B0.31373543
141RIPK40.30881696
142IRAK10.30430532
143CSNK2A20.30427710
144PKN20.29889275
145CDC42BPA0.29760998
146MAP3K60.29748069
147RPS6KA40.29533658
148CDK70.28731355
149VRK10.28141071
150IKBKB0.28045287
151DAPK30.27711312
152CSNK1A10.27495919
153GSK3A0.27034130
154CSNK2A10.26944042
155DYRK30.25717389
156FLT30.25180389

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001005.02977075
2* Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.87721419
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.92510709
4Fatty acid elongation_Homo sapiens_hsa000623.80691464
5Oxidative phosphorylation_Homo sapiens_hsa001903.73113228
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.08018812
7Parkinsons disease_Homo sapiens_hsa050122.92179482
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.80439884
9Proteasome_Homo sapiens_hsa030502.47111220
10Base excision repair_Homo sapiens_hsa034102.29630884
11Alzheimers disease_Homo sapiens_hsa050102.26482058
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.21051316
13Biosynthesis of amino acids_Homo sapiens_hsa012302.12348242
14Butanoate metabolism_Homo sapiens_hsa006502.09047495
15Sulfur metabolism_Homo sapiens_hsa009202.00355999
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.89970195
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.87268530
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.85220050
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.81694969
20Protein export_Homo sapiens_hsa030601.77404684
21Ether lipid metabolism_Homo sapiens_hsa005651.75892655
22Huntingtons disease_Homo sapiens_hsa050161.75683663
23Histidine metabolism_Homo sapiens_hsa003401.70605271
24Collecting duct acid secretion_Homo sapiens_hsa049661.66666862
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.62007934
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60212394
27Fructose and mannose metabolism_Homo sapiens_hsa000511.55848063
28DNA replication_Homo sapiens_hsa030301.46759401
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.45698905
30Fatty acid metabolism_Homo sapiens_hsa012121.42470358
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.38834339
32Propanoate metabolism_Homo sapiens_hsa006401.37249258
33Pyruvate metabolism_Homo sapiens_hsa006201.32351194
34Phenylalanine metabolism_Homo sapiens_hsa003601.32023350
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30703708
36Pyrimidine metabolism_Homo sapiens_hsa002401.29368685
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29005948
38Tyrosine metabolism_Homo sapiens_hsa003501.28704077
39Galactose metabolism_Homo sapiens_hsa000521.27836629
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.27349408
41* Peroxisome_Homo sapiens_hsa041461.26224210
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.25699337
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18149214
44Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.10540115
45Vibrio cholerae infection_Homo sapiens_hsa051101.08794327
46Vitamin B6 metabolism_Homo sapiens_hsa007501.07572011
47SNARE interactions in vesicular transport_Homo sapiens_hsa041301.06746577
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.05835275
49Lysosome_Homo sapiens_hsa041421.04777556
50Tryptophan metabolism_Homo sapiens_hsa003801.04744497
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.00958841
52Arginine and proline metabolism_Homo sapiens_hsa003301.00476466
53Linoleic acid metabolism_Homo sapiens_hsa005910.99501084
54Chemical carcinogenesis_Homo sapiens_hsa052040.94904568
55Synaptic vesicle cycle_Homo sapiens_hsa047210.93407832
56Glutathione metabolism_Homo sapiens_hsa004800.93278338
57Rheumatoid arthritis_Homo sapiens_hsa053230.93103035
58Serotonergic synapse_Homo sapiens_hsa047260.91247186
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89679001
60Other glycan degradation_Homo sapiens_hsa005110.89343229
61Cardiac muscle contraction_Homo sapiens_hsa042600.89302672
62beta-Alanine metabolism_Homo sapiens_hsa004100.86212524
63Sphingolipid metabolism_Homo sapiens_hsa006000.84598733
64Retinol metabolism_Homo sapiens_hsa008300.79049797
65Fatty acid degradation_Homo sapiens_hsa000710.78618659
66* Metabolic pathways_Homo sapiens_hsa011000.75443166
67Ribosome_Homo sapiens_hsa030100.71452567
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71383324
69Phototransduction_Homo sapiens_hsa047440.64847659
70GABAergic synapse_Homo sapiens_hsa047270.63108891
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62720687
72Fatty acid biosynthesis_Homo sapiens_hsa000610.62364904
73Phagosome_Homo sapiens_hsa041450.62142699
74Arginine biosynthesis_Homo sapiens_hsa002200.61861303
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60059169
76Folate biosynthesis_Homo sapiens_hsa007900.58986486
77Axon guidance_Homo sapiens_hsa043600.57910519
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57380047
79Arachidonic acid metabolism_Homo sapiens_hsa005900.55263912
80Mismatch repair_Homo sapiens_hsa034300.55235863
81Purine metabolism_Homo sapiens_hsa002300.55153121
82Allograft rejection_Homo sapiens_hsa053300.55077859
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54793134
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54082691
85PPAR signaling pathway_Homo sapiens_hsa033200.53401225
86Complement and coagulation cascades_Homo sapiens_hsa046100.52560328
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51545852
88Autoimmune thyroid disease_Homo sapiens_hsa053200.51099414
89Nucleotide excision repair_Homo sapiens_hsa034200.50136106
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48812827
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46342686
92N-Glycan biosynthesis_Homo sapiens_hsa005100.45142547
93Carbon metabolism_Homo sapiens_hsa012000.43723264
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43394962
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40771213
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.40769962
97Glutamatergic synapse_Homo sapiens_hsa047240.40618306
98Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40414340
99RNA polymerase_Homo sapiens_hsa030200.39902156
100Spliceosome_Homo sapiens_hsa030400.37618937
101Graft-versus-host disease_Homo sapiens_hsa053320.36641262
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36371349
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.35576763
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.35272596
105Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34000404
106Fat digestion and absorption_Homo sapiens_hsa049750.33268459
107Asthma_Homo sapiens_hsa053100.32617756
108Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.30162307
109Morphine addiction_Homo sapiens_hsa050320.28081991
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.27246104
111Staphylococcus aureus infection_Homo sapiens_hsa051500.25824053
112Type I diabetes mellitus_Homo sapiens_hsa049400.25588010
113One carbon pool by folate_Homo sapiens_hsa006700.24981575
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.23746733
115Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.23383527
116Nicotine addiction_Homo sapiens_hsa050330.22874189
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22503222
118Regulation of autophagy_Homo sapiens_hsa041400.22287131
119Vitamin digestion and absorption_Homo sapiens_hsa049770.22242012
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22027095
121Dopaminergic synapse_Homo sapiens_hsa047280.21994559
122Primary immunodeficiency_Homo sapiens_hsa053400.21870947
123Pentose phosphate pathway_Homo sapiens_hsa000300.21756188
124Shigellosis_Homo sapiens_hsa051310.21732905
125Long-term depression_Homo sapiens_hsa047300.21526677
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.20211169
127Prion diseases_Homo sapiens_hsa050200.20083837
128Endocytosis_Homo sapiens_hsa041440.19820210
129Cocaine addiction_Homo sapiens_hsa050300.18247322
130Nitrogen metabolism_Homo sapiens_hsa009100.18128862
131Pertussis_Homo sapiens_hsa051330.17820651
132Sulfur relay system_Homo sapiens_hsa041220.16933431
133Salmonella infection_Homo sapiens_hsa051320.16873965
134African trypanosomiasis_Homo sapiens_hsa051430.15279649
135Starch and sucrose metabolism_Homo sapiens_hsa005000.10268117
136Epstein-Barr virus infection_Homo sapiens_hsa051690.09748256

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