PNISR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ionotropic glutamate receptor signaling pathway (GO:0035235)5.27562608
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.16254085
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.80170825
4glutamate receptor signaling pathway (GO:0007215)4.69929769
5presynaptic membrane assembly (GO:0097105)4.64707542
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.59657640
7vocalization behavior (GO:0071625)4.54361268
8synaptic transmission, glutamatergic (GO:0035249)4.51983931
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.48453210
10neuron cell-cell adhesion (GO:0007158)4.42819499
11locomotory exploration behavior (GO:0035641)4.26523800
12presynaptic membrane organization (GO:0097090)4.23730983
13neurotransmitter-gated ion channel clustering (GO:0072578)4.11315131
14pyrimidine nucleobase catabolic process (GO:0006208)4.06064936
15neuron-neuron synaptic transmission (GO:0007270)4.05391020
16protein localization to synapse (GO:0035418)4.04476931
17membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.04432095
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.03834099
19postsynaptic membrane organization (GO:0001941)4.03561287
20regulation of glutamate receptor signaling pathway (GO:1900449)3.99202349
21G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.97042271
22regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.95466262
23neuronal action potential propagation (GO:0019227)3.95184809
24regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.87912804
25synaptic vesicle docking involved in exocytosis (GO:0016081)3.86460353
26cerebellar Purkinje cell differentiation (GO:0021702)3.84467272
27negative regulation of translation, ncRNA-mediated (GO:0040033)3.80042353
28regulation of translation, ncRNA-mediated (GO:0045974)3.80042353
29negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.80042353
30epithelial cilium movement (GO:0003351)3.72981369
31behavioral response to nicotine (GO:0035095)3.68032767
32cerebellar granule cell differentiation (GO:0021707)3.64390044
33negative regulation of synaptic transmission, GABAergic (GO:0032229)3.64072624
34regulation of excitatory postsynaptic membrane potential (GO:0060079)3.63657611
35synaptic vesicle exocytosis (GO:0016079)3.62639967
36positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.61728045
37transmission of nerve impulse (GO:0019226)3.59547552
38gamma-aminobutyric acid signaling pathway (GO:0007214)3.58429862
39glutamate secretion (GO:0014047)3.57887143
40histone H3-K4 trimethylation (GO:0080182)3.55360106
41startle response (GO:0001964)3.52138136
42neural tube formation (GO:0001841)3.51659235
43regulation of postsynaptic membrane potential (GO:0060078)3.50870113
44L-amino acid import (GO:0043092)3.49870946
45gamma-aminobutyric acid transport (GO:0015812)3.46842038
46long-term memory (GO:0007616)3.44515398
47neuron recognition (GO:0008038)3.42115233
48regulation of synaptic vesicle exocytosis (GO:2000300)3.41528361
49regulation of respiratory system process (GO:0044065)3.41268920
50synaptic vesicle maturation (GO:0016188)3.38339153
51response to pheromone (GO:0019236)3.35920564
52spinal cord association neuron differentiation (GO:0021527)3.34296921
53neurotransmitter secretion (GO:0007269)3.32445572
54regulation of synaptic transmission, glutamatergic (GO:0051966)3.32414465
55viral transcription (GO:0019083)3.32061876
56ribosomal small subunit assembly (GO:0000028)3.28563152
57translational termination (GO:0006415)3.27893576
58cilium movement (GO:0003341)3.26718646
59negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.25366705
60exploration behavior (GO:0035640)3.25027370
61cell proliferation in forebrain (GO:0021846)3.24841498
62nonmotile primary cilium assembly (GO:0035058)3.23911727
63cellular potassium ion homeostasis (GO:0030007)3.23747152
64auditory behavior (GO:0031223)3.23281474
65membrane depolarization during action potential (GO:0086010)3.23269842
66interkinetic nuclear migration (GO:0022027)3.22641547
67intraciliary transport (GO:0042073)3.22290229
68mechanosensory behavior (GO:0007638)3.19247080
69somite development (GO:0061053)3.17148348
70nucleobase catabolic process (GO:0046113)3.16772432
71synaptic vesicle endocytosis (GO:0048488)3.15247352
72long-term synaptic potentiation (GO:0060291)3.15180889
73positive regulation of membrane potential (GO:0045838)3.14908407
74regulation of neuronal synaptic plasticity (GO:0048168)3.14886537
75membrane depolarization (GO:0051899)3.10179366
76histone H3-K9 methylation (GO:0051567)3.09969147
77axonal fasciculation (GO:0007413)3.09396351
78regulation of long-term neuronal synaptic plasticity (GO:0048169)3.05154178
79cell differentiation in hindbrain (GO:0021533)3.03068171
80response to histamine (GO:0034776)3.02868150
81regulation of respiratory gaseous exchange (GO:0043576)3.01429560
82positive regulation of synapse maturation (GO:0090129)3.01227401
83regulation of synaptic vesicle transport (GO:1902803)2.99997983
84regulation of synapse maturation (GO:0090128)2.98725849
85centriole replication (GO:0007099)2.96441222
86positive regulation of synapse assembly (GO:0051965)2.96169710
87membrane hyperpolarization (GO:0060081)2.96158038
88central nervous system myelination (GO:0022010)2.94226703
89axon ensheathment in central nervous system (GO:0032291)2.94226703
90mRNA splice site selection (GO:0006376)2.93808326
91positive regulation of neurotransmitter secretion (GO:0001956)2.93516525
92regulation of neurotransmitter secretion (GO:0046928)2.91936138
93forebrain neuron differentiation (GO:0021879)2.91317030
94positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.90589470
95dendritic spine morphogenesis (GO:0060997)2.89476250
96head development (GO:0060322)2.88704682
97positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.88139888
98neurotransmitter transport (GO:0006836)2.88008768
99regulation of collateral sprouting (GO:0048670)2.87502756
100otic vesicle formation (GO:0030916)2.86825843
101dendrite morphogenesis (GO:0048813)2.86503363
102synapse assembly (GO:0007416)2.84574540
103neuronal ion channel clustering (GO:0045161)2.84445804
104regulation of dendritic spine morphogenesis (GO:0061001)2.81948672
105amino acid import (GO:0043090)2.80960115
106ncRNA catabolic process (GO:0034661)2.80433257
107monoubiquitinated protein deubiquitination (GO:0035520)2.80319876
108response to auditory stimulus (GO:0010996)2.78751839
109adult walking behavior (GO:0007628)2.78741727
110behavioral fear response (GO:0001662)2.78419525
111behavioral defense response (GO:0002209)2.78419525
112neuronal stem cell maintenance (GO:0097150)2.78194103
113regulation of synaptic plasticity (GO:0048167)2.78029571
114cilium or flagellum-dependent cell motility (GO:0001539)2.76371309
115olfactory bulb development (GO:0021772)2.75454813
116learning (GO:0007612)2.74049152
117regulation of synapse assembly (GO:0051963)2.73897330
118cilium organization (GO:0044782)2.73701560
119regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.73423182
120regulation of vesicle fusion (GO:0031338)2.73376697
121cell differentiation in spinal cord (GO:0021515)2.72158156
122central nervous system projection neuron axonogenesis (GO:0021952)2.71137812
123cilium assembly (GO:0042384)2.70703809
124tongue development (GO:0043586)2.70558909
125appendage development (GO:0048736)2.70267385
126limb development (GO:0060173)2.70267385
127fear response (GO:0042596)2.69742361
128regulation of non-canonical Wnt signaling pathway (GO:2000050)2.69716557
129seminiferous tubule development (GO:0072520)2.69373914
130spinal cord development (GO:0021510)2.69050529
131regulation of telomere maintenance (GO:0032204)2.66818418
132regulation of neurotransmitter transport (GO:0051588)2.66804742
133rRNA catabolic process (GO:0016075)2.66632828
134axoneme assembly (GO:0035082)2.65872276
135positive regulation of neurotransmitter transport (GO:0051590)2.65602940
136peptidyl-lysine trimethylation (GO:0018023)2.65274587
137hindbrain development (GO:0030902)2.63490232
138synapse organization (GO:0050808)2.62867040
139calcium ion import (GO:0070509)2.61492436
140regulation of neurotransmitter levels (GO:0001505)2.61392513
141retinal ganglion cell axon guidance (GO:0031290)2.61235614
142negative regulation of cytosolic calcium ion concentration (GO:0051481)2.60430167
143neuron fate determination (GO:0048664)2.60127772
144cell migration in hindbrain (GO:0021535)2.58877062
145regulation of dendritic spine development (GO:0060998)2.58355992
146negative regulation of DNA-dependent DNA replication (GO:2000104)2.57705911
147neuromuscular synaptic transmission (GO:0007274)2.57422799
148positive regulation of dendritic spine morphogenesis (GO:0061003)2.57100072
149positive regulation of synaptic transmission, GABAergic (GO:0032230)2.56669525
150protein polyglutamylation (GO:0018095)2.55613959
151reciprocal meiotic recombination (GO:0007131)2.54981628
152reciprocal DNA recombination (GO:0035825)2.54981628
153cerebral cortex radially oriented cell migration (GO:0021799)2.54870672
154regulation of voltage-gated calcium channel activity (GO:1901385)2.54855041
155histone H3-K9 modification (GO:0061647)2.52817945
156negative regulation of astrocyte differentiation (GO:0048712)2.51129795
157activated T cell proliferation (GO:0050798)2.48619206
158regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.47800984
159dentate gyrus development (GO:0021542)2.47304556
160translational elongation (GO:0006414)2.47251372
161forebrain morphogenesis (GO:0048853)2.46656621
162regulation of cilium movement (GO:0003352)2.45425642
163cardiovascular system development (GO:0072358)2.44886483
164regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.44139709
165nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.43830424
166photoreceptor cell maintenance (GO:0045494)2.43456755
167axonemal dynein complex assembly (GO:0070286)2.43438506
168negative regulation of neurotransmitter transport (GO:0051589)2.41604530
169replication fork processing (GO:0031297)2.41272059
170negative regulation of transcription regulatory region DNA binding (GO:2000678)2.40240678
171cellular protein complex disassembly (GO:0043624)2.37210788
172regulation of gene silencing by RNA (GO:0060966)2.35931943
173regulation of posttranscriptional gene silencing (GO:0060147)2.35931943
174regulation of gene silencing by miRNA (GO:0060964)2.35931943
175kidney morphogenesis (GO:0060993)2.34755626
176protein localization to cilium (GO:0061512)2.34033690
177peptidyl-lysine methylation (GO:0018022)2.32790282
178pituitary gland development (GO:0021983)2.32548741
179establishment of mitochondrion localization (GO:0051654)2.30943907
180negative regulation of neurotransmitter secretion (GO:0046929)2.29914957
181cotranslational protein targeting to membrane (GO:0006613)2.29509242

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.90632310
2GBX2_23144817_ChIP-Seq_PC3_Human4.23324557
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.49796346
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.00536472
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.90268400
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.69309746
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.67109489
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.62459399
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.58723380
10VDR_22108803_ChIP-Seq_LS180_Human2.39276509
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.32975631
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.28475723
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.28475723
14TAF15_26573619_Chip-Seq_HEK293_Human2.25130696
15DROSHA_22980978_ChIP-Seq_HELA_Human2.25087995
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.24549399
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24312681
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.23848749
19SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.14590102
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.14132987
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.13233314
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.12497567
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.07029639
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.04774909
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99621114
26REST_21632747_ChIP-Seq_MESCs_Mouse1.99189724
27TP63_19390658_ChIP-ChIP_HaCaT_Human1.98282356
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.95403581
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.92988683
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88259306
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.85783564
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85344214
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.83357625
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82253052
35AR_21572438_ChIP-Seq_LNCaP_Human1.80190196
36SMAD4_21799915_ChIP-Seq_A2780_Human1.78599122
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76698736
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76629715
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.75967939
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75148490
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.74782537
42P300_19829295_ChIP-Seq_ESCs_Human1.71228406
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70324584
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68886105
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.68133906
46FUS_26573619_Chip-Seq_HEK293_Human1.67273016
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.66987647
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.62090813
49IRF1_19129219_ChIP-ChIP_H3396_Human1.58780120
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.56080832
51STAT3_23295773_ChIP-Seq_U87_Human1.46888295
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46600303
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45574737
54TP53_16413492_ChIP-PET_HCT116_Human1.42964773
55REST_18959480_ChIP-ChIP_MESCs_Mouse1.42398236
56AR_25329375_ChIP-Seq_VCAP_Human1.37996723
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37969998
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37893942
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36674978
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36283536
61TCF4_23295773_ChIP-Seq_U87_Human1.36037642
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35415998
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34345837
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34226066
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33945875
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32006401
67SOX2_21211035_ChIP-Seq_LN229_Gbm1.31961088
68NANOG_18555785_Chip-Seq_ESCs_Mouse1.31880144
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31107769
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.30855212
71HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30799865
72ZNF274_21170338_ChIP-Seq_K562_Hela1.30477599
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.28880903
74RNF2_27304074_Chip-Seq_NSC_Mouse1.28739020
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28704901
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28704901
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28553774
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28084608
79CBP_20019798_ChIP-Seq_JUKART_Human1.28084608
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25829624
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24755901
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21776429
83AR_19668381_ChIP-Seq_PC3_Human1.21533576
84AHR_22903824_ChIP-Seq_MCF-7_Human1.17279579
85P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17100561
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17061079
87RUNX2_22187159_ChIP-Seq_PCA_Human1.16971205
88E2F1_18555785_Chip-Seq_ESCs_Mouse1.16859238
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16609739
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15428765
91YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15204000
92MYC_18940864_ChIP-ChIP_HL60_Human1.13922226
93FLI1_27457419_Chip-Seq_LIVER_Mouse1.13480361
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12847099
95ER_23166858_ChIP-Seq_MCF-7_Human1.12715540
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11794172
97EWS_26573619_Chip-Seq_HEK293_Human1.11477544
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10469993
99PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09607953
100PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09497938
101MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09174427
102EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09100840
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08867649
104RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08733740
105TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08715602
106RING1B_27294783_Chip-Seq_ESCs_Mouse1.08384760
107PRDM14_20953172_ChIP-Seq_ESCs_Human1.08075387
108KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07993711
109WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07943060
110P53_22387025_ChIP-Seq_ESCs_Mouse1.07691868
111ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07442318
112FLI1_21867929_ChIP-Seq_TH2_Mouse1.07291276
113CMYC_18555785_Chip-Seq_ESCs_Mouse1.05415145
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05113800
115IGF1R_20145208_ChIP-Seq_DFB_Human1.03521632
116BCAT_22108803_ChIP-Seq_LS180_Human1.02214012
117SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02122933
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01255575
119KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00769655
120SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00613211
121TCF4_22108803_ChIP-Seq_LS180_Human1.00009808
122TAL1_26923725_Chip-Seq_HPCs_Mouse0.99942708
123FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99909882
124RING1B_27294783_Chip-Seq_NPCs_Mouse0.99331570
125TP53_22573176_ChIP-Seq_HFKS_Human0.99178328
126TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98854305
127WDR5_24793694_ChIP-Seq_LNCAP_Human0.96822419
128STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96538110
129EZH2_27294783_Chip-Seq_NPCs_Mouse0.95781534
130SOX9_26525672_Chip-Seq_HEART_Mouse0.95363082
131SMAD3_21741376_ChIP-Seq_ESCs_Human0.95217876
132LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93952877

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.90123070
2MP0003880_abnormal_central_pattern4.41388526
3MP0003635_abnormal_synaptic_transmissio3.48932220
4MP0009745_abnormal_behavioral_response3.11357411
5MP0003787_abnormal_imprinting3.03822632
6MP0009046_muscle_twitch3.00917470
7MP0002064_seizures2.82774759
8MP0002063_abnormal_learning/memory/cond2.79400502
9MP0001486_abnormal_startle_reflex2.79163776
10MP0004270_analgesia2.73424992
11MP0005423_abnormal_somatic_nervous2.72098337
12MP0002572_abnormal_emotion/affect_behav2.63507027
13MP0002272_abnormal_nervous_system2.52841532
14MP0001968_abnormal_touch/_nociception2.40910951
15MP0001501_abnormal_sleep_pattern2.31505668
16MP0002067_abnormal_sensory_capabilities2.13887012
17MP0005409_darkened_coat_color2.10324815
18MP0002736_abnormal_nociception_after2.07905425
19MP0005646_abnormal_pituitary_gland2.06508734
20MP0001440_abnormal_grooming_behavior2.02203797
21MP0004885_abnormal_endolymph1.99518650
22MP0000778_abnormal_nervous_system1.98740579
23MP0009379_abnormal_foot_pigmentation1.95473341
24MP0002822_catalepsy1.93834868
25MP0002734_abnormal_mechanical_nocicepti1.93719003
26MP0003890_abnormal_embryonic-extraembry1.92353824
27MP0008569_lethality_at_weaning1.88888793
28MP0006292_abnormal_olfactory_placode1.86582098
29MP0008789_abnormal_olfactory_epithelium1.84744146
30MP0002557_abnormal_social/conspecific_i1.84506628
31MP0001188_hyperpigmentation1.83330278
32MP0000569_abnormal_digit_pigmentation1.82354953
33MP0004133_heterotaxia1.80015220
34MP0005551_abnormal_eye_electrophysiolog1.78297421
35MP0002735_abnormal_chemical_nociception1.74927569
36MP0001984_abnormal_olfaction1.66839237
37MP0002184_abnormal_innervation1.66275526
38MP0004145_abnormal_muscle_electrophysio1.60747366
39MP0008995_early_reproductive_senescence1.60613454
40MP0001293_anophthalmia1.54913263
41MP0009780_abnormal_chondrocyte_physiolo1.53655689
42MP0005386_behavior/neurological_phenoty1.51024369
43MP0004924_abnormal_behavior1.51024369
44MP0001502_abnormal_circadian_rhythm1.50868995
45MP0002882_abnormal_neuron_morphology1.43852010
46MP0003123_paternal_imprinting1.43806160
47MP0004142_abnormal_muscle_tone1.43480928
48MP0000955_abnormal_spinal_cord1.42936723
49MP0002938_white_spotting1.41075496
50MP0003567_abnormal_fetal_cardiomyocyte1.38747084
51MP0006072_abnormal_retinal_apoptosis1.37943653
52MP0004742_abnormal_vestibular_system1.37736311
53MP0008877_abnormal_DNA_methylation1.36477051
54MP0002102_abnormal_ear_morphology1.35501011
55MP0001970_abnormal_pain_threshold1.34952302
56MP0005171_absent_coat_pigmentation1.31419240
57MP0003122_maternal_imprinting1.29121687
58MP0002733_abnormal_thermal_nociception1.28309214
59MP0003121_genomic_imprinting1.27979034
60MP0001485_abnormal_pinna_reflex1.26930723
61MP0005645_abnormal_hypothalamus_physiol1.26527548
62MP0001986_abnormal_taste_sensitivity1.25525061
63MP0002066_abnormal_motor_capabilities/c1.23790104
64MP0000631_abnormal_neuroendocrine_gland1.18846649
65MP0006276_abnormal_autonomic_nervous1.16753866
66MP0002152_abnormal_brain_morphology1.16403406
67MP0001963_abnormal_hearing_physiology1.14678162
68MP0002928_abnormal_bile_duct1.14388656
69MP0003879_abnormal_hair_cell1.11311468
70MP0003633_abnormal_nervous_system1.10676654
71MP0008057_abnormal_DNA_replication1.10354936
72MP0004811_abnormal_neuron_physiology1.09138251
73MP0005377_hearing/vestibular/ear_phenot1.09009520
74MP0003878_abnormal_ear_physiology1.09009520
75MP0005253_abnormal_eye_physiology1.08541874
76MP0002638_abnormal_pupillary_reflex1.05558048
77MP0008058_abnormal_DNA_repair1.04622178
78MP0002229_neurodegeneration1.03892638
79MP0002752_abnormal_somatic_nervous1.03456907
80MP0010386_abnormal_urinary_bladder1.02897587
81MP0004147_increased_porphyrin_level1.02019137
82MP0003136_yellow_coat_color1.01261766
83MP0003631_nervous_system_phenotype1.00740560
84MP0003937_abnormal_limbs/digits/tail_de0.97469060
85MP0000427_abnormal_hair_cycle0.96201423
86MP0000920_abnormal_myelination0.95689878
87MP0002095_abnormal_skin_pigmentation0.94547233
88MP0002909_abnormal_adrenal_gland0.94424812
89MP0001286_abnormal_eye_development0.93818964
90MP0000566_synostosis0.92455778
91MP0001905_abnormal_dopamine_level0.92047764
92MP0005394_taste/olfaction_phenotype0.91879137
93MP0005499_abnormal_olfactory_system0.91879137
94MP0004085_abnormal_heartbeat0.90719218
95MP0003632_abnormal_nervous_system0.89192074
96MP0000026_abnormal_inner_ear0.89188363
97MP0002751_abnormal_autonomic_nervous0.87852590
98MP0005075_abnormal_melanosome_morpholog0.87678574
99MP0003690_abnormal_glial_cell0.87128601
100MP0005174_abnormal_tail_pigmentation0.87021316
101MP0002653_abnormal_ependyma_morphology0.87020180
102MP0002069_abnormal_eating/drinking_beha0.84710026
103MP0001529_abnormal_vocalization0.83826466
104MP0003698_abnormal_male_reproductive0.82017219
105MP0003634_abnormal_glial_cell0.81130281
106MP0002233_abnormal_nose_morphology0.80760812
107MP0005391_vision/eye_phenotype0.79695470
108MP0004215_abnormal_myocardial_fiber0.77846390
109MP0002210_abnormal_sex_determination0.77631942
110MP0002160_abnormal_reproductive_system0.77535151
111MP0003137_abnormal_impulse_conducting0.76698850
112MP0003119_abnormal_digestive_system0.75379607
113MP0003283_abnormal_digestive_organ0.74528999
114MP0001177_atelectasis0.73442410
115MP0001324_abnormal_eye_pigmentation0.73314871
116MP0003861_abnormal_nervous_system0.73187650
117MP0001299_abnormal_eye_distance/0.72421130
118MP0005195_abnormal_posterior_eye0.72389456
119MP0000015_abnormal_ear_pigmentation0.71876803
120MP0000653_abnormal_sex_gland0.69728587
121MP0003938_abnormal_ear_development0.68920199
122MP0008872_abnormal_physiological_respon0.66911947
123MP0001664_abnormal_digestion0.66859552
124MP0004043_abnormal_pH_regulation0.66393239
125MP0000751_myopathy0.66296772
126MP0010770_preweaning_lethality0.66276777
127MP0002082_postnatal_lethality0.66276777
128MP0004858_abnormal_nervous_system0.66047395
129MP0010769_abnormal_survival0.64276930
130MP0003329_amyloid_beta_deposits0.62530418
131MP0010768_mortality/aging0.61492748
132MP0001943_abnormal_respiration0.58917423
133MP0000049_abnormal_middle_ear0.56795738

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.35225268
2Epileptic encephalopathy (HP:0200134)4.82706414
3Febrile seizures (HP:0002373)4.54392477
4Focal seizures (HP:0007359)4.43315736
5Pancreatic fibrosis (HP:0100732)4.23246375
6Progressive cerebellar ataxia (HP:0002073)4.03420029
7Broad-based gait (HP:0002136)3.81699475
8Atonic seizures (HP:0010819)3.80101145
9Pancreatic cysts (HP:0001737)3.62394256
10True hermaphroditism (HP:0010459)3.59766022
11Hyperventilation (HP:0002883)3.51055244
12Gaze-evoked nystagmus (HP:0000640)3.41138137
13Abnormality of the renal medulla (HP:0100957)3.21532654
14Septo-optic dysplasia (HP:0100842)3.18668520
15Protruding tongue (HP:0010808)3.18550786
16Visual hallucinations (HP:0002367)3.08521225
17Absence seizures (HP:0002121)3.07928625
18Myokymia (HP:0002411)3.03998602
19Excessive salivation (HP:0003781)3.03597586
20Drooling (HP:0002307)3.03597586
21Dialeptic seizures (HP:0011146)2.98238033
22Hemiparesis (HP:0001269)2.92235719
23Diplopia (HP:0000651)2.82300732
24Abnormality of binocular vision (HP:0011514)2.82300732
25Genetic anticipation (HP:0003743)2.75106626
26Absent speech (HP:0001344)2.70584538
27Cystic liver disease (HP:0006706)2.65306583
28Blue irides (HP:0000635)2.64516556
29Generalized tonic-clonic seizures (HP:0002069)2.62187807
30Action tremor (HP:0002345)2.58000911
31Abnormality of the renal cortex (HP:0011035)2.52695362
32Colon cancer (HP:0003003)2.52341081
33Hemiplegia (HP:0002301)2.51070337
34Dysdiadochokinesis (HP:0002075)2.46607873
35Poor coordination (HP:0002370)2.45517274
36Reticulocytopenia (HP:0001896)2.44277514
37Scanning speech (HP:0002168)2.41750101
38Volvulus (HP:0002580)2.39658768
39Abnormal hair whorl (HP:0010721)2.38527455
40Vaginal atresia (HP:0000148)2.36630564
41Postaxial foot polydactyly (HP:0001830)2.35531011
42Truncal ataxia (HP:0002078)2.33819515
43Oligodactyly (hands) (HP:0001180)2.33614252
44Abnormality of the labia minora (HP:0012880)2.33263224
45Aplasia/Hypoplasia of the spleen (HP:0010451)2.32613677
46Rib fusion (HP:0000902)2.31669037
47Aplasia involving bones of the upper limbs (HP:0009823)2.31331846
48Aplasia of the phalanges of the hand (HP:0009802)2.31331846
49Aplasia involving bones of the extremities (HP:0009825)2.31331846
50Dysmetria (HP:0001310)2.29751235
51Abnormal respiratory epithelium morphology (HP:0012253)2.27240069
52Abnormal respiratory motile cilium morphology (HP:0005938)2.27240069
53Asplenia (HP:0001746)2.26378480
54Optic nerve hypoplasia (HP:0000609)2.23527746
55Supernumerary spleens (HP:0009799)2.22652776
56Widely spaced teeth (HP:0000687)2.21756891
57Bile duct proliferation (HP:0001408)2.20113724
58Abnormal biliary tract physiology (HP:0012439)2.20113724
59Chronic hepatic failure (HP:0100626)2.19916775
60Anencephaly (HP:0002323)2.18084448
61Impaired smooth pursuit (HP:0007772)2.17357460
62Poor eye contact (HP:0000817)2.14763922
63Congenital hepatic fibrosis (HP:0002612)2.13211758
64Abnormality of salivation (HP:0100755)2.13083067
65Sclerocornea (HP:0000647)2.12821959
66Growth hormone deficiency (HP:0000824)2.12506371
67Hepatoblastoma (HP:0002884)2.11773670
68Postaxial hand polydactyly (HP:0001162)2.10732278
69Dynein arm defect of respiratory motile cilia (HP:0012255)2.06992483
70Absent/shortened dynein arms (HP:0200106)2.06992483
71Exotropia (HP:0000577)2.05544201
72Narrow nasal bridge (HP:0000446)2.03800994
73Intestinal atresia (HP:0011100)2.03776196
74Narrow forehead (HP:0000341)2.03221599
75Abnormality of ocular smooth pursuit (HP:0000617)2.03164456
76Abnormality of cells of the erythroid lineage (HP:0012130)2.01385828
77Aqueductal stenosis (HP:0002410)2.00982653
78Gastroesophageal reflux (HP:0002020)1.99294856
79Tubular atrophy (HP:0000092)1.96329790
80Stereotypic behavior (HP:0000733)1.95755640
81Specific learning disability (HP:0001328)1.95250390
82Impaired social interactions (HP:0000735)1.94540273
83Abnormal social behavior (HP:0012433)1.94540273
84Fair hair (HP:0002286)1.94471582
85Polydipsia (HP:0001959)1.94366137
86Abnormal drinking behavior (HP:0030082)1.94366137
87Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94227712
88Acute lymphatic leukemia (HP:0006721)1.93455542
89Absent septum pellucidum (HP:0001331)1.93181325
90Supranuclear gaze palsy (HP:0000605)1.92295744
91Impaired vibration sensation in the lower limbs (HP:0002166)1.91470926
92Abnormal respiratory motile cilium physiology (HP:0012261)1.91227623
93Anophthalmia (HP:0000528)1.90848011
94Male pseudohermaphroditism (HP:0000037)1.89519530
95Aplasia/Hypoplasia of the tongue (HP:0010295)1.89116851
96Deeply set eye (HP:0000490)1.87147537
97Absent rod-and cone-mediated responses on ERG (HP:0007688)1.86901031
98Amblyopia (HP:0000646)1.85116549
99Postural instability (HP:0002172)1.83430545
100Preaxial hand polydactyly (HP:0001177)1.81172469
101Renal cortical cysts (HP:0000803)1.81058123
102Gait imbalance (HP:0002141)1.80367237
103Epileptiform EEG discharges (HP:0011182)1.78099737
104Abnormality of the septum pellucidum (HP:0007375)1.77741006
105Mixed hearing impairment (HP:0000410)1.77313949
106Clumsiness (HP:0002312)1.77301620
107Stomach cancer (HP:0012126)1.77284972
108Generalized hypopigmentation of hair (HP:0011358)1.76716996
109Hyperglycinemia (HP:0002154)1.75739291
110Thickened helices (HP:0000391)1.75689033
111Urinary bladder sphincter dysfunction (HP:0002839)1.75655432
112Neoplasm of the heart (HP:0100544)1.75024856
113Highly arched eyebrow (HP:0002553)1.74952159
114Midline defect of the nose (HP:0004122)1.73503567
115Abnormal ciliary motility (HP:0012262)1.73371890
116Abnormality of the aortic arch (HP:0012303)1.73230302
117Medial flaring of the eyebrow (HP:0010747)1.73123665
118Inappropriate behavior (HP:0000719)1.72870982
119Optic nerve coloboma (HP:0000588)1.72561173
120Hypoplastic nipples (HP:0002557)1.71199096
121Thyroid-stimulating hormone excess (HP:0002925)1.70776513
122Depressed nasal ridge (HP:0000457)1.70276650
123Abnormal rod and cone electroretinograms (HP:0008323)1.70179371
124Abnormality of chromosome stability (HP:0003220)1.68996917
125Autism (HP:0000717)1.68618847
126Multicystic kidney dysplasia (HP:0000003)1.68358791
127Abnormality of the corticospinal tract (HP:0002492)1.68123183
128Obsessive-compulsive behavior (HP:0000722)1.67091731
129Supernumerary bones of the axial skeleton (HP:0009144)1.67032020
130Dysmetric saccades (HP:0000641)1.66384647
131Short foot (HP:0001773)1.66024071
132Prominent nasal bridge (HP:0000426)1.65831196
133Ectopic kidney (HP:0000086)1.65361353
134Congenital stationary night blindness (HP:0007642)1.64579126
135Patellar aplasia (HP:0006443)1.64532671
136Broad foot (HP:0001769)1.64143780
137Congenital primary aphakia (HP:0007707)1.63632883
138Panhypogammaglobulinemia (HP:0003139)1.63019385
139Tubulointerstitial nephritis (HP:0001970)1.62732166
140Sloping forehead (HP:0000340)1.62150074
141Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.61116960
142Degeneration of the lateral corticospinal tracts (HP:0002314)1.61116960
143Genital tract atresia (HP:0001827)1.61012179
144Dandy-Walker malformation (HP:0001305)1.60948898
145Hip dysplasia (HP:0001385)1.60825391
146Confusion (HP:0001289)1.60386005
147Depression (HP:0000716)1.60165199
148Aganglionic megacolon (HP:0002251)1.59946692
149Anteriorly placed anus (HP:0001545)1.59638009
150Labial hypoplasia (HP:0000066)1.59197044
151Status epilepticus (HP:0002133)1.58877977
152Abnormality of the nasal septum (HP:0000419)1.58172546
153Nephronophthisis (HP:0000090)1.58051679
154Prolonged QT interval (HP:0001657)1.57865193
155Supernumerary ribs (HP:0005815)1.57582439
156EEG with generalized epileptiform discharges (HP:0011198)1.57265934
157Abnormal eating behavior (HP:0100738)1.56919587
158Nephrogenic diabetes insipidus (HP:0009806)1.55003911
159Cutaneous finger syndactyly (HP:0010554)1.54993534
160Impaired vibratory sensation (HP:0002495)1.54912981
161Anxiety (HP:0000739)1.54821374
162Ankle clonus (HP:0011448)1.54800197
163Tented upper lip vermilion (HP:0010804)1.54045162
164Abnormality of midbrain morphology (HP:0002418)1.53872127
165Molar tooth sign on MRI (HP:0002419)1.53872127
166Anal stenosis (HP:0002025)1.53155855

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.12847491
2EPHA43.97326175
3NTRK33.72068388
4TNIK3.57238261
5MAP3K42.74671179
6MAP2K72.54357019
7FRK2.44239223
8NTRK22.03259677
9PRPF4B2.02731972
10MAPK131.94265852
11SIK21.94067382
12CDC71.93241058
13MAP4K21.90946701
14PNCK1.79594901
15BMPR1B1.74134974
16BRD41.73878124
17CAMK1G1.65733895
18RIPK41.56758630
19INSRR1.56701216
20SGK21.53024246
21MARK11.52833334
22DAPK21.46590968
23DYRK21.41707581
24TAOK31.41108418
25MKNK21.33827407
26WNK11.33145332
27FES1.32658350
28SGK2231.31775641
29SGK4941.31775641
30CDK31.29471250
31WNK41.28627686
32OXSR11.28116240
33MAP2K41.27101446
34AKT31.24098067
35TEC1.23888284
36MAP3K131.19378528
37MAPK151.19220427
38PAK61.18224497
39SGK31.17889492
40DYRK31.16158010
41CDK191.14969039
42MAP3K91.14770112
43MINK11.13892502
44NEK61.13006023
45PASK1.12581526
46CDK51.10305159
47PLK21.07569782
48TNK21.06981275
49YES11.05668927
50MARK21.05350632
51SIK31.02819750
52DYRK1A1.02220990
53SGK11.00858396
54ZAK1.00799980
55CDC42BPA0.99706017
56NLK0.98057900
57CAMKK20.98003478
58STK380.96677816
59CAMK10.94802277
60PLK40.93919152
61MUSK0.92406136
62BRSK20.92175925
63TAF10.91834951
64CAMK2A0.90294105
65FGFR20.88430454
66CAMK2B0.88006882
67PRKCG0.86867711
68PHKG20.85045820
69PHKG10.85045820
70GRK10.84476038
71TXK0.82405390
72DAPK10.82065273
73NUAK10.81763712
74CAMK1D0.81352874
75KIT0.79217709
76PRKCH0.78298801
77KSR10.76759472
78UHMK10.75414400
79PRKD20.73354246
80CAMKK10.73169052
81NEK20.71164716
82CSNK1E0.70080897
83WEE10.69015461
84PRKCE0.67914404
85PINK10.67780115
86ITK0.67286471
87PKN10.66881805
88ATR0.66286933
89CAMK40.65986697
90MAP3K120.64804924
91MAP3K70.64597349
92PTK2B0.64223023
93STK110.63142328
94CSNK1G20.62794044
95PRKG10.62213948
96FGR0.62079106
97ATM0.61736643
98GRK70.61327460
99DYRK1B0.61055009
100STK390.60927403
101DMPK0.59831263
102ERBB20.59433717
103BMPR20.59415388
104MAPK70.59018583
105MAPK100.58410737
106TGFBR10.58282075
107MAP3K60.56932085
108BTK0.56633540
109PIK3CA0.56503940
110RPS6KA30.56271553
111MKNK10.55309555
112CSNK1A1L0.55138294
113OBSCN0.53914926
114TYRO30.53544579
115PRKD30.52527452
116GSK3B0.50342388
117CAMK2D0.49436587
118PRKDC0.48799292
119MAPK120.48739066
120CLK10.48558507
121FYN0.48153394
122ACVR1B0.46504573
123GRK50.46410328
124SYK0.46154016
125PRKCB0.46039045
126FLT30.43743954
127ADRBK20.43525858
128PRKCQ0.42949176
129ERBB30.40888802
130CSNK1G10.40824677
131CSNK1A10.40715958
132MAPK80.39849457
133BCR0.39255101
134WNK30.38100576
135PRKACA0.37786164
136PAK30.37398360

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.41647129
2Ribosome_Homo sapiens_hsa030102.98855799
3Glutamatergic synapse_Homo sapiens_hsa047242.88791125
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.85873368
5Circadian entrainment_Homo sapiens_hsa047132.77414107
6Morphine addiction_Homo sapiens_hsa050322.62821362
7GABAergic synapse_Homo sapiens_hsa047272.62243470
8Long-term potentiation_Homo sapiens_hsa047202.52899637
9Amphetamine addiction_Homo sapiens_hsa050312.34406927
10Olfactory transduction_Homo sapiens_hsa047402.23610457
11Salivary secretion_Homo sapiens_hsa049702.19575079
12Homologous recombination_Homo sapiens_hsa034402.17323206
13Synaptic vesicle cycle_Homo sapiens_hsa047212.16284560
14Taste transduction_Homo sapiens_hsa047422.14313575
15Non-homologous end-joining_Homo sapiens_hsa034502.04543980
16Fanconi anemia pathway_Homo sapiens_hsa034601.97699450
17Insulin secretion_Homo sapiens_hsa049111.92300012
18Dopaminergic synapse_Homo sapiens_hsa047281.88626219
19Long-term depression_Homo sapiens_hsa047301.86193983
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.85247312
21Calcium signaling pathway_Homo sapiens_hsa040201.83462301
22Linoleic acid metabolism_Homo sapiens_hsa005911.81012683
23Renin secretion_Homo sapiens_hsa049241.79887220
24RNA degradation_Homo sapiens_hsa030181.78341814
25Serotonergic synapse_Homo sapiens_hsa047261.74021022
26Phototransduction_Homo sapiens_hsa047441.73659441
27Gastric acid secretion_Homo sapiens_hsa049711.70793913
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68327254
29Cholinergic synapse_Homo sapiens_hsa047251.64278929
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60814634
31Basal transcription factors_Homo sapiens_hsa030221.59816453
32Cocaine addiction_Homo sapiens_hsa050301.58438038
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.55595461
34Oxytocin signaling pathway_Homo sapiens_hsa049211.54112122
35cAMP signaling pathway_Homo sapiens_hsa040241.49709727
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.46893491
37Oxidative phosphorylation_Homo sapiens_hsa001901.40301508
38Axon guidance_Homo sapiens_hsa043601.39933477
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36760056
40Parkinsons disease_Homo sapiens_hsa050121.33570860
41Butanoate metabolism_Homo sapiens_hsa006501.31646803
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.29473727
43Type II diabetes mellitus_Homo sapiens_hsa049301.23225698
44GnRH signaling pathway_Homo sapiens_hsa049121.21638855
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18309901
46Protein export_Homo sapiens_hsa030601.17630954
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15927163
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13658469
49Regulation of autophagy_Homo sapiens_hsa041401.12563252
50Primary immunodeficiency_Homo sapiens_hsa053401.11578086
51Circadian rhythm_Homo sapiens_hsa047101.09767094
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09115504
53ErbB signaling pathway_Homo sapiens_hsa040121.08977573
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07527294
55Propanoate metabolism_Homo sapiens_hsa006401.06186074
56Gap junction_Homo sapiens_hsa045401.04961229
57Pancreatic secretion_Homo sapiens_hsa049721.04549743
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03558200
59Spliceosome_Homo sapiens_hsa030401.02774676
60Vascular smooth muscle contraction_Homo sapiens_hsa042701.02682609
61Huntingtons disease_Homo sapiens_hsa050161.01867201
62Collecting duct acid secretion_Homo sapiens_hsa049660.99141227
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98826284
64Melanogenesis_Homo sapiens_hsa049160.96086977
65Nitrogen metabolism_Homo sapiens_hsa009100.93135523
66Choline metabolism in cancer_Homo sapiens_hsa052310.92719736
67Selenocompound metabolism_Homo sapiens_hsa004500.92375071
68Dorso-ventral axis formation_Homo sapiens_hsa043200.91911453
69Asthma_Homo sapiens_hsa053100.91343204
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.88856038
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.87539151
72Dilated cardiomyopathy_Homo sapiens_hsa054140.85949948
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.85242775
74Estrogen signaling pathway_Homo sapiens_hsa049150.84121746
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83161279
76Wnt signaling pathway_Homo sapiens_hsa043100.81805482
77MAPK signaling pathway_Homo sapiens_hsa040100.81539758
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79071050
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79013227
80Inositol phosphate metabolism_Homo sapiens_hsa005620.78336709
81Peroxisome_Homo sapiens_hsa041460.75735019
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75095720
83Glioma_Homo sapiens_hsa052140.74923334
84Alzheimers disease_Homo sapiens_hsa050100.72778864
85RNA transport_Homo sapiens_hsa030130.71492957
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70751587
87Notch signaling pathway_Homo sapiens_hsa043300.67998670
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67712098
89Ras signaling pathway_Homo sapiens_hsa040140.67509467
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65490520
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64549236
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64178121
93Thyroid hormone synthesis_Homo sapiens_hsa049180.64062602
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63588574
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62756011
96Caffeine metabolism_Homo sapiens_hsa002320.62439560
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61993548
98Base excision repair_Homo sapiens_hsa034100.61891329
99Rap1 signaling pathway_Homo sapiens_hsa040150.61842038
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61164544
101Colorectal cancer_Homo sapiens_hsa052100.59928121
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59196631
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58365604
104Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56875779
105ABC transporters_Homo sapiens_hsa020100.56372301
106Basal cell carcinoma_Homo sapiens_hsa052170.56231248
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55598055
108Hedgehog signaling pathway_Homo sapiens_hsa043400.55552425
109Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55476923
110Fatty acid biosynthesis_Homo sapiens_hsa000610.55303848
111Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55202317
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54778586
113Glycerolipid metabolism_Homo sapiens_hsa005610.54764065
114Lysine degradation_Homo sapiens_hsa003100.52238760
115RNA polymerase_Homo sapiens_hsa030200.51749017
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51265736
117Hippo signaling pathway_Homo sapiens_hsa043900.51117921
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50688699
119Glucagon signaling pathway_Homo sapiens_hsa049220.49596626
120Cardiac muscle contraction_Homo sapiens_hsa042600.49340027
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48333482
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47832971
123Vibrio cholerae infection_Homo sapiens_hsa051100.47092780
124Oocyte meiosis_Homo sapiens_hsa041140.46662402
125Steroid biosynthesis_Homo sapiens_hsa001000.46573400
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45756185
127Ovarian steroidogenesis_Homo sapiens_hsa049130.45363667
128Endometrial cancer_Homo sapiens_hsa052130.43515220
129SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43253310
130Ether lipid metabolism_Homo sapiens_hsa005650.43133599
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.41549313
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40259205
133Chemokine signaling pathway_Homo sapiens_hsa040620.38662839
134Alcoholism_Homo sapiens_hsa050340.38577724
135T cell receptor signaling pathway_Homo sapiens_hsa046600.37676586
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.36633782
137Renal cell carcinoma_Homo sapiens_hsa052110.35919406
138Non-small cell lung cancer_Homo sapiens_hsa052230.34208899
139African trypanosomiasis_Homo sapiens_hsa051430.32436535
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32380488
141Sphingolipid metabolism_Homo sapiens_hsa006000.32091017
142mRNA surveillance pathway_Homo sapiens_hsa030150.31861633
143Neurotrophin signaling pathway_Homo sapiens_hsa047220.31824041
144Mineral absorption_Homo sapiens_hsa049780.30762766
145Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28295139
146Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26198278

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