PNKD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is thought to play a role in the regulation of myofibrillogenesis. Mutations in this gene have been associated with the movement disorder paroxysmal non-kinesigenic dyskinesia. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.33159993
2L-phenylalanine catabolic process (GO:0006559)4.32147860
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.32147860
4L-phenylalanine metabolic process (GO:0006558)4.16028884
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.16028884
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.14016520
7complement activation, alternative pathway (GO:0006957)3.82227061
8glutamate secretion (GO:0014047)3.81677649
9gamma-aminobutyric acid transport (GO:0015812)3.72019006
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.68783498
11synaptic vesicle exocytosis (GO:0016079)3.68017404
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.64655615
13positive regulation of lipoprotein lipase activity (GO:0051006)3.58651005
14positive regulation of triglyceride lipase activity (GO:0061365)3.58651005
15aromatic amino acid family catabolic process (GO:0009074)3.56178800
16neuronal action potential propagation (GO:0019227)3.55428308
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.54742062
18neurotransmitter secretion (GO:0007269)3.53198234
19locomotory exploration behavior (GO:0035641)3.52065129
20synaptic vesicle docking involved in exocytosis (GO:0016081)3.49389321
21cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.48216284
22glutamate metabolic process (GO:0006536)3.37168739
23cellular ketone body metabolic process (GO:0046950)3.35295385
24glycine transport (GO:0015816)3.34701731
25bile acid biosynthetic process (GO:0006699)3.32632806
26neutrophil activation involved in immune response (GO:0002283)3.30271851
27energy coupled proton transport, down electrochemical gradient (GO:0015985)3.30243577
28ATP synthesis coupled proton transport (GO:0015986)3.30243577
29aspartate family amino acid catabolic process (GO:0009068)3.28745685
30glycosphingolipid catabolic process (GO:0046479)3.27139030
31regulation of synaptic vesicle exocytosis (GO:2000300)3.26277919
32glyoxylate metabolic process (GO:0046487)3.24412029
33dicarboxylic acid biosynthetic process (GO:0043650)3.23888769
34vocalization behavior (GO:0071625)3.23138234
35dicarboxylic acid catabolic process (GO:0043649)3.21386461
36alpha-linolenic acid metabolic process (GO:0036109)3.20913505
37blood coagulation, intrinsic pathway (GO:0007597)3.19963598
38lysine metabolic process (GO:0006553)3.19124054
39lysine catabolic process (GO:0006554)3.19124054
40regulation of superoxide anion generation (GO:0032928)3.17110804
41kynurenine metabolic process (GO:0070189)3.16999536
42cell communication by electrical coupling (GO:0010644)3.16775397
43regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.16290856
44respiratory electron transport chain (GO:0022904)3.15430022
45regulation of neuronal synaptic plasticity (GO:0048168)3.13321647
46cellular response to thyroid hormone stimulus (GO:0097067)3.10988276
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.10140671
48electron transport chain (GO:0022900)3.08902926
49neurotransmitter-gated ion channel clustering (GO:0072578)3.08235957
50regulation of synaptic vesicle transport (GO:1902803)3.06438870
51regulation of glutamate receptor signaling pathway (GO:1900449)3.04122210
52response to thyroid hormone (GO:0097066)3.02887814
53mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.00952244
54positive regulation of fatty acid biosynthetic process (GO:0045723)3.00359302
55short-chain fatty acid metabolic process (GO:0046459)2.99868183
56cellular response to cadmium ion (GO:0071276)2.98421785
57* neuromuscular process controlling posture (GO:0050884)2.98186397
58sodium ion export (GO:0071436)2.98007212
59fibrinolysis (GO:0042730)2.96885235
60tryptophan catabolic process (GO:0006569)2.95617931
61indole-containing compound catabolic process (GO:0042436)2.95617931
62indolalkylamine catabolic process (GO:0046218)2.95617931
63neurotransmitter transport (GO:0006836)2.92715372
64regulation of macrophage chemotaxis (GO:0010758)2.91141361
65cellular potassium ion homeostasis (GO:0030007)2.90816240
66negative regulation of cholesterol transport (GO:0032375)2.90563528
67negative regulation of sterol transport (GO:0032372)2.90563528
68regulation of long-term neuronal synaptic plasticity (GO:0048169)2.89304172
69ketone body metabolic process (GO:1902224)2.88558546
70positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.87908143
71glycolipid catabolic process (GO:0019377)2.87663266
72coenzyme catabolic process (GO:0009109)2.86788773
73regulation of mononuclear cell migration (GO:0071675)2.86478955
74high-density lipoprotein particle remodeling (GO:0034375)2.83684690
75triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.83655241
76ATP hydrolysis coupled proton transport (GO:0015991)2.83555034
77energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.83555034
78ionotropic glutamate receptor signaling pathway (GO:0035235)2.83275421
79regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.83264747
80phospholipid efflux (GO:0033700)2.83099658
81acute-phase response (GO:0006953)2.82065706
82regulation of cholesterol esterification (GO:0010872)2.81608182
83regulation of neurotransmitter levels (GO:0001505)2.81340797
84sulfur amino acid catabolic process (GO:0000098)2.80864661
85positive regulation of cellular amine metabolic process (GO:0033240)2.80224563
86regulation of synapse structural plasticity (GO:0051823)2.79439275
87plasma lipoprotein particle remodeling (GO:0034369)2.78987468
88protein-lipid complex remodeling (GO:0034368)2.78987468
89alpha-amino acid catabolic process (GO:1901606)2.78536128
90protein carboxylation (GO:0018214)2.78000161
91peptidyl-glutamic acid carboxylation (GO:0017187)2.78000161
92protein localization to synapse (GO:0035418)2.77192987
93succinate metabolic process (GO:0006105)2.75872174
94cellular amino acid catabolic process (GO:0009063)2.74984003
95regulation of protein activation cascade (GO:2000257)2.71608317
96oligosaccharide catabolic process (GO:0009313)2.71301144
97bile acid metabolic process (GO:0008206)2.70802874
98fat-soluble vitamin biosynthetic process (GO:0042362)2.69416750
99phagosome maturation (GO:0090382)2.68335063
100central nervous system myelination (GO:0022010)2.67870443
101axon ensheathment in central nervous system (GO:0032291)2.67870443
102response to peptidoglycan (GO:0032494)2.67742502
103regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.67003152
104proline transport (GO:0015824)2.66776654
105cysteine metabolic process (GO:0006534)2.66641601
106transferrin transport (GO:0033572)2.66391731
107deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.66317275
108hydrogen peroxide biosynthetic process (GO:0050665)2.66054349
109negative regulation of myeloid cell apoptotic process (GO:0033033)2.65669622
110synaptic transmission, glutamatergic (GO:0035249)2.65483308
111tryptophan metabolic process (GO:0006568)2.65004842
112exploration behavior (GO:0035640)2.64934854
113fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.64917093
114regulation of oxidative phosphorylation (GO:0002082)2.64088951
115acetyl-CoA metabolic process (GO:0006084)2.63676497
116L-amino acid import (GO:0043092)2.62923853
117negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.61526092
118cellular response to zinc ion (GO:0071294)2.60720564
119adenosine receptor signaling pathway (GO:0001973)2.60111966
120aldehyde catabolic process (GO:0046185)2.59874924
121regulation of complement activation (GO:0030449)2.59290093
122cellular modified amino acid catabolic process (GO:0042219)2.58961480
123low-density lipoprotein particle remodeling (GO:0034374)2.58660717
124aromatic amino acid family metabolic process (GO:0009072)2.58046894
125serine family amino acid catabolic process (GO:0009071)2.57342925
126positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.56922021
127neuron-neuron synaptic transmission (GO:0007270)2.56740353
128tricarboxylic acid cycle (GO:0006099)2.55486726
129cyclooxygenase pathway (GO:0019371)2.54834502
130long-term memory (GO:0007616)2.54236077
131fatty acid elongation (GO:0030497)2.53857649
132ceramide catabolic process (GO:0046514)2.53289113
133cell communication involved in cardiac conduction (GO:0086065)2.52663830
134very long-chain fatty acid metabolic process (GO:0000038)2.52431120
1352-oxoglutarate metabolic process (GO:0006103)2.52036830
136chaperone-mediated protein transport (GO:0072321)2.51727477
137epoxygenase P450 pathway (GO:0019373)2.51657449
138cholesterol efflux (GO:0033344)2.51632347
139potassium ion import (GO:0010107)2.50811255
140reactive oxygen species biosynthetic process (GO:1903409)2.49542540
141activation of protein kinase A activity (GO:0034199)2.49066867
142reverse cholesterol transport (GO:0043691)2.48999315
143plasma lipoprotein particle clearance (GO:0034381)2.48275444
144positive regulation of membrane potential (GO:0045838)2.46622967
145cellular sodium ion homeostasis (GO:0006883)2.46589359
146glutamine family amino acid catabolic process (GO:0009065)2.46556294
147regulation of fibrinolysis (GO:0051917)2.46390453
148purine nucleotide salvage (GO:0032261)2.45991409
149negative regulation of synaptic transmission, GABAergic (GO:0032229)2.44928317
150negative regulation of blood coagulation (GO:0030195)2.44581709
151negative regulation of hemostasis (GO:1900047)2.44581709
152NADH metabolic process (GO:0006734)2.43939667
153regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.43816189
154amino sugar catabolic process (GO:0046348)2.43600699
155ferric iron transport (GO:0015682)2.43464107
156trivalent inorganic cation transport (GO:0072512)2.43464107
157ethanol oxidation (GO:0006069)2.42977781
158regulation of cholesterol biosynthetic process (GO:0045540)2.42769394
159xenobiotic catabolic process (GO:0042178)2.42762159
160positive regulation of potassium ion transmembrane transport (GO:1901381)2.42471657
161behavioral response to cocaine (GO:0048148)2.42443598
162hydrogen ion transmembrane transport (GO:1902600)2.41680554
163regulation of mast cell degranulation (GO:0043304)2.40768187
164nitrogen cycle metabolic process (GO:0071941)2.40764019
165negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.40640808
166protein activation cascade (GO:0072376)2.40101997
167alanine transport (GO:0032328)2.38007125
168macromolecular complex remodeling (GO:0034367)2.37916265
169negative regulation of interleukin-12 production (GO:0032695)2.37747068
170lipopolysaccharide-mediated signaling pathway (GO:0031663)2.37020110
171ribosomal small subunit biogenesis (GO:0042274)2.35865254
172protein neddylation (GO:0045116)2.33609080
173negative regulation of erythrocyte differentiation (GO:0045647)2.32831935
174protein maturation by protein folding (GO:0022417)2.30789864
175lipoxygenase pathway (GO:0019372)2.30656427
176urea metabolic process (GO:0019627)2.30640756
177complement activation (GO:0006956)2.29391537
178viral transcription (GO:0019083)2.29355542
179negative regulation of coagulation (GO:0050819)2.28193755
180negative regulation of fibrinolysis (GO:0051918)2.28043214
181pentose metabolic process (GO:0019321)2.27962303
182GDP-mannose metabolic process (GO:0019673)2.27422596
183acute inflammatory response (GO:0002526)2.27085483
184oxaloacetate metabolic process (GO:0006107)2.26947568
185arginine catabolic process (GO:0006527)2.26866459
186ATP biosynthetic process (GO:0006754)2.26353134

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.25308626
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.07786560
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.21546198
4RXR_22158963_ChIP-Seq_LIVER_Mouse2.79714813
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.78795295
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.60263541
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.56365142
8NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.55393934
9GBX2_23144817_ChIP-Seq_PC3_Human2.52036004
10* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.47289350
11SRY_22984422_ChIP-ChIP_TESTIS_Rat2.38402187
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.28058266
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.28058266
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.27162831
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.26991216
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.25861182
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25383539
18* REST_21632747_ChIP-Seq_MESCs_Mouse2.24197519
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24126022
20LXR_22158963_ChIP-Seq_LIVER_Mouse2.22490866
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.21284074
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.19806857
23FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.18239588
24* CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.11533378
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.11483906
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.09963295
27DROSHA_22980978_ChIP-Seq_HELA_Human2.07568018
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.04537069
29ERG_21242973_ChIP-ChIP_JURKAT_Human2.00744126
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.00713762
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.00648261
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00555208
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.99479777
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93476586
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.93269289
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.93141583
37VDR_21846776_ChIP-Seq_THP-1_Human1.91118359
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.90606660
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.89004819
40ELF1_20517297_ChIP-Seq_JURKAT_Human1.85530749
41ZNF263_19887448_ChIP-Seq_K562_Human1.85395381
42* IRF8_22096565_ChIP-ChIP_GC-B_Human1.83888899
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.81128280
44NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.73199806
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.72570703
46* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.71568250
47BCL6_27268052_Chip-Seq_Bcells_Human1.70372269
48IRF8_21731497_ChIP-ChIP_J774_Mouse1.69216820
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.61099656
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.60229692
51BCOR_27268052_Chip-Seq_Bcells_Human1.60154805
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.59150872
53* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.58200796
54RARG_19884340_ChIP-ChIP_MEFs_Mouse1.56080280
55TET1_21451524_ChIP-Seq_MESCs_Mouse1.55869488
56JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.55344565
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.55172631
58P68_20966046_ChIP-Seq_HELA_Human1.52542974
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.51889864
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.51657893
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49780923
62EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49252534
63* VDR_24763502_ChIP-Seq_THP-1_Human1.48355461
64LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.44628363
65DNAJC2_21179169_ChIP-ChIP_NT2_Human1.41491848
66AR_21572438_ChIP-Seq_LNCaP_Human1.39921049
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38298973
68EGR1_23403033_ChIP-Seq_LIVER_Mouse1.37916729
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.36716252
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35794607
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34815681
72NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.33557484
73RACK7_27058665_Chip-Seq_MCF-7_Human1.32284344
74MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32012892
75SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31465068
76PU.1_20513432_ChIP-Seq_Bcells_Mouse1.30796381
77SCL_19346495_ChIP-Seq_HPC-7_Human1.30432737
78SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30392073
79CTCF_18555785_ChIP-Seq_MESCs_Mouse1.30145526
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.30037766
81* GATA1_19941827_ChIP-Seq_MEL_Mouse1.28897281
82SA1_27219007_Chip-Seq_Bcells_Human1.28687572
83CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27630984
84CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27129998
85GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26614376
86ELK3_25401928_ChIP-Seq_HUVEC_Human1.25753685
87* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25664531
88PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25420173
89YY1_22570637_ChIP-Seq_MALME-3M_Human1.25333163
90RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23906553
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23595766
92* SPI1_23127762_ChIP-Seq_K562_Human1.23579522
93* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23466951
94NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23435813
95* CTCF_26484167_Chip-Seq_Bcells_Mouse1.23181504
96TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22107698
97MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.21390443
98* CTCF_20526341_ChIP-Seq_ESCs_Human1.20731205
99E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19498679
100CTCF_27219007_Chip-Seq_Bcells_Human1.19255769
101TAF15_26573619_Chip-Seq_HEK293_Human1.16611586
102IRF8_27001747_Chip-Seq_BMDM_Mouse1.16260841
103ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16157530
104* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16129613
105CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15746933
106STAT1_20625510_ChIP-Seq_HELA_Human1.14840996
107GATA1_19941826_ChIP-Seq_K562_Human1.14158154
108BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.12451257
109TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12225640
110CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11863474
111* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11370499
112SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10883128
113CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10597728
114RING1B_27294783_Chip-Seq_ESCs_Mouse1.09350237
115* SRF_21415370_ChIP-Seq_HL-1_Mouse1.08406792
116SPI1_20517297_ChIP-Seq_HL60_Human1.08317278
117RUNX1_22412390_ChIP-Seq_EML_Mouse1.06496395
118HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.06395913
119SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06364555
120CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05955314
121SPI1_23547873_ChIP-Seq_NB4_Human1.05774249
122E2F1_20622854_ChIP-Seq_HELA_Human1.05636771
123ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04985571
124HTT_18923047_ChIP-ChIP_STHdh_Human1.04908908
125PHF8_20622854_ChIP-Seq_HELA_Human1.04905668
126SMAD4_21799915_ChIP-Seq_A2780_Human1.04006939
127TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02584741
128* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02215776
129CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01583829
130* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00174802
131STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99710115
132TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99561715
133CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99439021
134ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99378136
135* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99216055
136PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98671303
137SOX2_21211035_ChIP-Seq_LN229_Gbm0.98323893
138* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97974181
139SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97343933
140SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97210105
141ESR2_21235772_ChIP-Seq_MCF-7_Human0.96860061
142* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96348218
143SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93170681
144SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92266922
145KDM2B_26808549_Chip-Seq_K562_Human0.91927388
146* FOXA2_19822575_ChIP-Seq_HepG2_Human0.91378944
147PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91264453
148EP300_21415370_ChIP-Seq_HL-1_Mouse0.90520841
149SMAD4_21741376_ChIP-Seq_HESCs_Human0.90071840
150TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89917356
151RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89535028
152ESR1_20079471_ChIP-ChIP_T-47D_Human0.88479490
153AR_19668381_ChIP-Seq_PC3_Human0.86993175
154CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86521218
155TET1_21490601_ChIP-Seq_MESCs_Mouse0.86361609
156ZNF274_21170338_ChIP-Seq_K562_Hela0.85430509
157MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84510524
158KLF4_19829295_ChIP-Seq_ESCs_Human0.84228653
159TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.80990070
160AR_25329375_ChIP-Seq_VCAP_Human0.80700632
161* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79420594
162TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.77997289
163SMAD3_21741376_ChIP-Seq_EPCs_Human0.77795502
164BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77784054
165LXR_22292898_ChIP-Seq_THP-1_Human0.77239185
166OCT4_19829295_ChIP-Seq_ESCs_Human0.75891120
167PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.75280546
168STAT3_23295773_ChIP-Seq_U87_Human0.75029799
169SMAD4_21741376_ChIP-Seq_EPCs_Human0.74885208
170P300_19829295_ChIP-Seq_ESCs_Human0.74271784
171* SMC4_20622854_ChIP-Seq_HELA_Human0.73824616
172RAD21_21589869_ChIP-Seq_MESCs_Mouse0.73151150
173SMAD3_21741376_ChIP-Seq_HESCs_Human0.73055773
174GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72994116
175RING1B_27294783_Chip-Seq_NPCs_Mouse0.72003137
176CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.71885109
177RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.71584976
178P53_22127205_ChIP-Seq_FIBROBLAST_Human0.70772729
179ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.68680627
180CBX2_27304074_Chip-Seq_ESCs_Mouse0.68209349

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.57546235
2MP0005058_abnormal_lysosome_morphology4.22599486
3MP0002139_abnormal_hepatobiliary_system3.78529659
4MP0003880_abnormal_central_pattern3.46086914
5MP0005360_urolithiasis3.37714085
6MP0005085_abnormal_gallbladder_physiolo3.10618811
7MP0002822_catalepsy3.03957478
8MP0003635_abnormal_synaptic_transmissio2.94298372
9MP0003303_peritoneal_inflammation2.78128133
10MP0005365_abnormal_bile_salt2.65496164
11MP0005464_abnormal_platelet_physiology2.65177147
12MP0004270_analgesia2.62896935
13MP0009745_abnormal_behavioral_response2.60527074
14MP0002064_seizures2.56648354
15MP0009046_muscle_twitch2.46594905
16MP0008875_abnormal_xenobiotic_pharmacok2.35089777
17MP0002148_abnormal_hypersensitivity_rea2.31764731
18MP0003436_decreased_susceptibility_to2.29393414
19MP0003172_abnormal_lysosome_physiology2.28208031
20MP0002063_abnormal_learning/memory/cond2.25880378
21MP0002272_abnormal_nervous_system2.25365035
22MP0000343_altered_response_to2.22746313
23MP0004510_myositis2.13512411
24MP0001486_abnormal_startle_reflex2.05722385
25MP0009785_altered_susceptibility_to2.05185579
26MP0003806_abnormal_nucleotide_metabolis2.03340307
27MP0003329_amyloid_beta_deposits2.01422764
28MP0003195_calcinosis1.96503701
29MP0001968_abnormal_touch/_nociception1.96130491
30MP0002572_abnormal_emotion/affect_behav1.95460444
31MP0003186_abnormal_redox_activity1.92897020
32MP0003646_muscle_fatigue1.92384742
33MP0009278_abnormal_bone_marrow1.91505430
34MP0005423_abnormal_somatic_nervous1.82905752
35MP0005397_hematopoietic_system_phenotyp1.81696282
36MP0001545_abnormal_hematopoietic_system1.81696282
37MP0002837_dystrophic_cardiac_calcinosis1.75390738
38MP0005025_abnormal_response_to1.75366138
39MP0002734_abnormal_mechanical_nocicepti1.73883915
40MP0001501_abnormal_sleep_pattern1.73788681
41MP0005332_abnormal_amino_acid1.71553487
42MP0002419_abnormal_innate_immunity1.70015423
43MP0004142_abnormal_muscle_tone1.68137842
44MP0002736_abnormal_nociception_after1.62430317
45MP0010329_abnormal_lipoprotein_level1.59650145
46MP0006082_CNS_inflammation1.59354043
47MP0000751_myopathy1.58462480
48MP0001853_heart_inflammation1.56058791
49MP0005083_abnormal_biliary_tract1.54776163
50MP0003690_abnormal_glial_cell1.51858354
51MP0009764_decreased_sensitivity_to1.51469673
52MP0008260_abnormal_autophagy1.50181082
53MP0005000_abnormal_immune_tolerance1.47964950
54MP0004043_abnormal_pH_regulation1.47768651
55MP0004885_abnormal_endolymph1.47593377
56MP0009840_abnormal_foam_cell1.47220968
57MP0008569_lethality_at_weaning1.46324222
58MP0002067_abnormal_sensory_capabilities1.44398460
59MP0005166_decreased_susceptibility_to1.44296936
60MP0001440_abnormal_grooming_behavior1.41874812
61MP0002733_abnormal_thermal_nociception1.39530959
62MP0008469_abnormal_protein_level1.38699702
63MP0001764_abnormal_homeostasis1.38448687
64MP0003724_increased_susceptibility_to1.38226278
65MP0003252_abnormal_bile_duct1.37120469
66MP0002735_abnormal_chemical_nociception1.33248822
67MP0005451_abnormal_body_composition1.32797860
68MP0005386_behavior/neurological_phenoty1.32767650
69MP0004924_abnormal_behavior1.32767650
70MP0005646_abnormal_pituitary_gland1.31578810
71MP0001970_abnormal_pain_threshold1.31480119
72MP0000920_abnormal_myelination1.31014672
73MP0004036_abnormal_muscle_relaxation1.29588122
74MP0005387_immune_system_phenotype1.28654359
75MP0001790_abnormal_immune_system1.28654359
76MP0001533_abnormal_skeleton_physiology1.28564634
77MP0008004_abnormal_stomach_pH1.28411280
78MP0001835_abnormal_antigen_presentation1.27924143
79MP0004858_abnormal_nervous_system1.27171952
80MP0003633_abnormal_nervous_system1.24973075
81MP0006276_abnormal_autonomic_nervous1.24131972
82MP0001845_abnormal_inflammatory_respons1.24060413
83MP0004147_increased_porphyrin_level1.22533836
84MP0006036_abnormal_mitochondrial_physio1.22392881
85MP0009780_abnormal_chondrocyte_physiolo1.21048667
86MP0003137_abnormal_impulse_conducting1.20958857
87MP0005584_abnormal_enzyme/coenzyme_acti1.19275243
88MP0002118_abnormal_lipid_homeostasis1.19207581
89MP0003879_abnormal_hair_cell1.19070442
90MP0004215_abnormal_myocardial_fiber1.17828467
91MP0001529_abnormal_vocalization1.17718001
92MP0003656_abnormal_erythrocyte_physiolo1.17211147
93MP0002066_abnormal_motor_capabilities/c1.16588894
94MP0009379_abnormal_foot_pigmentation1.15422734
95MP0005535_abnormal_body_temperature1.15360177
96MP0002909_abnormal_adrenal_gland1.14833979
97MP0001905_abnormal_dopamine_level1.14164136
98MP0002132_abnormal_respiratory_system1.13898071
99MP0000604_amyloidosis1.13591617
100MP0000955_abnormal_spinal_cord1.12302425
101MP0005636_abnormal_mineral_homeostasis1.10708460
102MP0003191_abnormal_cellular_cholesterol1.10648114
103MP0008872_abnormal_physiological_respon1.09906747
104MP0004811_abnormal_neuron_physiology1.09819278
105MP0002229_neurodegeneration1.09280697
106MP0003631_nervous_system_phenotype1.08914818
107MP0000749_muscle_degeneration1.08018240
108MP0005671_abnormal_response_to1.07999385
109MP0002723_abnormal_immune_serum1.06524156
110MP0009333_abnormal_splenocyte_physiolog1.05740061
111MP0005330_cardiomyopathy1.04163883
112MP0002452_abnormal_antigen_presenting1.03451145
113MP0004085_abnormal_heartbeat1.01333311
114MP0004084_abnormal_cardiac_muscle1.00593665
115MP0002557_abnormal_social/conspecific_i0.99782576
116MP0009763_increased_sensitivity_to0.98387525
117MP0004130_abnormal_muscle_cell0.97755669
118MP0000778_abnormal_nervous_system0.97418680
119MP0008874_decreased_physiological_sensi0.96794272
120MP0002653_abnormal_ependyma_morphology0.96365837
121MP0002882_abnormal_neuron_morphology0.95754574
122MP0001666_abnormal_nutrient_absorption0.95242796
123MP0009643_abnormal_urine_homeostasis0.95127502
124MP0000609_abnormal_liver_physiology0.95098839
125MP0006035_abnormal_mitochondrial_morpho0.93355927
126MP0003638_abnormal_response/metabolism_0.93218275
127MP0010155_abnormal_intestine_physiology0.92798530
128MP0001502_abnormal_circadian_rhythm0.92098412
129MP0003011_delayed_dark_adaptation0.90972125
130MP0002138_abnormal_hepatobiliary_system0.90016071
131MP0004019_abnormal_vitamin_homeostasis0.89478848
132MP0005165_increased_susceptibility_to0.88730785
133MP0000685_abnormal_immune_system0.88088869
134MP0005551_abnormal_eye_electrophysiolog0.87857837
135MP0003075_altered_response_to0.87321252
136MP0002998_abnormal_bone_remodeling0.87124790
137MP0001819_abnormal_immune_cell0.86762974
138MP0005167_abnormal_blood-brain_barrier0.86589904
139MP0002184_abnormal_innervation0.86084138
140MP0002420_abnormal_adaptive_immunity0.85920351
141MP0003634_abnormal_glial_cell0.85816781
142MP0004145_abnormal_muscle_electrophysio0.85712980
143MP0002876_abnormal_thyroid_physiology0.85032588
144MP0001756_abnormal_urination0.84543156
145MP0003632_abnormal_nervous_system0.84274841
146MP0004947_skin_inflammation0.82954271
147MP0009765_abnormal_xenobiotic_induced0.82900221
148MP0000747_muscle_weakness0.81879605
149MP0005310_abnormal_salivary_gland0.81747634
150MP0000858_altered_metastatic_potential0.81138882
151MP0002269_muscular_atrophy0.79245811
152MP0009642_abnormal_blood_homeostasis0.78186931
153MP0001984_abnormal_olfaction0.77924927
154MP0001485_abnormal_pinna_reflex0.77168429
155MP0001800_abnormal_humoral_immune0.77148545
156MP0004233_abnormal_muscle_weight0.77080685
157MP0006138_congestive_heart_failure0.76688855
158MP0005084_abnormal_gallbladder_morpholo0.76288874
159MP0003183_abnormal_peptide_metabolism0.75265252
160MP0002069_abnormal_eating/drinking_beha0.74705000
161MP0005319_abnormal_enzyme/_coenzyme0.70010044
162MP0005620_abnormal_muscle_contractility0.69843440
163MP0002090_abnormal_vision0.69605841
164MP0001663_abnormal_digestive_system0.67293850

Predicted human phenotypes

RankGene SetZ-score
1* Myokymia (HP:0002411)5.39375096
2Systemic lupus erythematosus (HP:0002725)5.28263332
3Abnormality of liposaccharide metabolism (HP:0010968)4.83553088
4Abnormality of glycosphingolipid metabolism (HP:0004343)4.83553088
5Abnormality of glycolipid metabolism (HP:0010969)4.83553088
6Focal motor seizures (HP:0011153)4.74490652
7Purpura (HP:0000979)4.39718077
8Abnormality of aromatic amino acid family metabolism (HP:0004338)4.07549459
9Petechiae (HP:0000967)3.74979370
10Glomerulonephritis (HP:0000099)3.62552537
11Increased cerebral lipofuscin (HP:0011813)3.55429742
12Intrahepatic cholestasis (HP:0001406)3.55124055
13Dysostosis multiplex (HP:0000943)3.41098717
14Deep venous thrombosis (HP:0002625)3.35190653
15Pheochromocytoma (HP:0002666)3.35121461
16Vacuolated lymphocytes (HP:0001922)3.33609967
17Generalized aminoaciduria (HP:0002909)3.28096386
18Focal seizures (HP:0007359)3.20218374
19Abnormality of complement system (HP:0005339)3.17577083
20Increased neuronal autofluorescent lipopigment (HP:0002074)3.17128549
21Renal Fanconi syndrome (HP:0001994)3.12740967
22Increased serum ferritin (HP:0003281)3.08422391
23Abnormality of macrophages (HP:0004311)3.07789164
24Ankle clonus (HP:0011448)3.04494896
25Hyperglycinemia (HP:0002154)3.01553063
26Mutism (HP:0002300)2.99240963
27Recurrent gram-negative bacterial infections (HP:0005420)2.97400208
28Hyperammonemia (HP:0001987)2.97093820
29Neuroendocrine neoplasm (HP:0100634)2.95224044
30Action tremor (HP:0002345)2.94692464
31Supranuclear gaze palsy (HP:0000605)2.94237032
32Ketosis (HP:0001946)2.93889400
33Epileptic encephalopathy (HP:0200134)2.82695577
34Visual hallucinations (HP:0002367)2.82309360
35Generalized tonic-clonic seizures (HP:0002069)2.80226538
36Joint hemorrhage (HP:0005261)2.79377731
37Abnormality of mucopolysaccharide metabolism (HP:0011020)2.77074540
38Abnormality of polysaccharide metabolism (HP:0011012)2.77074540
39Abnormality of glycosaminoglycan metabolism (HP:0004371)2.77074540
40Abnormality of glycine metabolism (HP:0010895)2.74779698
41Abnormality of serine family amino acid metabolism (HP:0010894)2.74779698
42Ventricular fibrillation (HP:0001663)2.73608205
43Mitochondrial inheritance (HP:0001427)2.73416416
44Xanthomatosis (HP:0000991)2.69377702
45Hyperventilation (HP:0002883)2.66870378
46Hyperglycinuria (HP:0003108)2.64715468
47Atonic seizures (HP:0010819)2.64320902
48Abnormality of iron homeostasis (HP:0011031)2.64201134
49Progressive cerebellar ataxia (HP:0002073)2.63120184
50Hyperlipoproteinemia (HP:0010980)2.62160306
51Acute encephalopathy (HP:0006846)2.61710645
52Prolonged bleeding time (HP:0003010)2.61082778
53Loss of speech (HP:0002371)2.59850442
54Hepatosplenomegaly (HP:0001433)2.58311999
55Cerebral edema (HP:0002181)2.56470463
56Abnormality of monocarboxylic acid metabolism (HP:0010996)2.56211137
57Anxiety (HP:0000739)2.55350351
58Exercise-induced myalgia (HP:0003738)2.54950486
59Ketoacidosis (HP:0001993)2.54370021
60Dysmetria (HP:0001310)2.53299043
61Status epilepticus (HP:0002133)2.53050973
62Neurofibrillary tangles (HP:0002185)2.53045244
63Delayed CNS myelination (HP:0002188)2.52974850
64Hypobetalipoproteinemia (HP:0003563)2.49896426
65Absence seizures (HP:0002121)2.49325674
66Urinary glycosaminoglycan excretion (HP:0003541)2.47513266
67Mucopolysacchariduria (HP:0008155)2.47513266
68Increased intramyocellular lipid droplets (HP:0012240)2.47480447
69Postural instability (HP:0002172)2.47292336
70Recurrent abscess formation (HP:0002722)2.46482537
71Prolonged partial thromboplastin time (HP:0003645)2.45046629
72Gout (HP:0001997)2.44363876
73Abnormal gallbladder physiology (HP:0012438)2.42721266
74Cholecystitis (HP:0001082)2.42721266
75Prolonged neonatal jaundice (HP:0006579)2.41212877
76Abnormality of the lower motor neuron (HP:0002366)2.41007664
77Epistaxis (HP:0000421)2.40972521
78Increased muscle lipid content (HP:0009058)2.40145582
79Dysdiadochokinesis (HP:0002075)2.39328995
80Sudden death (HP:0001699)2.38657145
81Febrile seizures (HP:0002373)2.37850177
82Axonal loss (HP:0003447)2.37136672
83Bundle branch block (HP:0011710)2.35632777
84Intention tremor (HP:0002080)2.32747425
85Abnormal mitochondria in muscle tissue (HP:0008316)2.32512771
86Decreased activity of mitochondrial respiratory chain (HP:0008972)2.32476390
87Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.32476390
88Gingival bleeding (HP:0000225)2.31605464
89Nausea (HP:0002018)2.28884258
90Abnormality of fatty-acid metabolism (HP:0004359)2.28030582
91Impaired social interactions (HP:0000735)2.27949019
92Abnormal social behavior (HP:0012433)2.27949019
93* Torticollis (HP:0000473)2.27626845
94Acute necrotizing encephalopathy (HP:0006965)2.27597612
95* Focal dystonia (HP:0004373)2.26967907
96Spastic gait (HP:0002064)2.26634776
97Impaired vibration sensation in the lower limbs (HP:0002166)2.26372809
98Increased CSF lactate (HP:0002490)2.26221849
99Dialeptic seizures (HP:0011146)2.24819290
100Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.22116927
101Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.22022799
102Poor eye contact (HP:0000817)2.21120581
103Complement deficiency (HP:0004431)2.19235121
104Neuronal loss in central nervous system (HP:0002529)2.17993298
105Menorrhagia (HP:0000132)2.16850842
106Progressive neurologic deterioration (HP:0002344)2.15983098
107Obstructive lung disease (HP:0006536)2.15587596
108Chronic obstructive pulmonary disease (HP:0006510)2.15587596
109Abnormality of lateral ventricle (HP:0030047)2.14658038
110* Craniofacial dystonia (HP:0012179)2.13759865
111Abnormal eating behavior (HP:0100738)2.12218999
112Abnormality of transition element cation homeostasis (HP:0011030)2.12023940
113Depression (HP:0000716)2.10344449
114Lethargy (HP:0001254)2.10237814
115Amyloidosis (HP:0011034)2.10096373
116Clonus (HP:0002169)2.08886962
117Cerebral hemorrhage (HP:0001342)2.08537482
118Hepatic necrosis (HP:0002605)2.05074299
119Syncope (HP:0001279)2.04019194
120Dicarboxylic aciduria (HP:0003215)2.03962221
121Abnormality of dicarboxylic acid metabolism (HP:0010995)2.03962221
122Abnormal platelet function (HP:0011869)2.03875744
123Impaired platelet aggregation (HP:0003540)2.03875744
124Metabolic acidosis (HP:0001942)2.02722566
125Increased hepatocellular lipid droplets (HP:0006565)2.01138996
126Abnormality of aspartate family amino acid metabolism (HP:0010899)1.99897002
127Abnormality of glutamine family amino acid metabolism (HP:0010902)1.99820029
128Cholelithiasis (HP:0001081)1.99670100
129Heart block (HP:0012722)1.99506006
130Nephritis (HP:0000123)1.99415001
131Abnormal gallbladder morphology (HP:0012437)1.98467872
132Scanning speech (HP:0002168)1.97880847
133Sensorimotor neuropathy (HP:0007141)1.97563641
134Hepatocellular necrosis (HP:0001404)1.97474753
135Prolonged QT interval (HP:0001657)1.96502508
136Hypoglycemic coma (HP:0001325)1.95989645
137Leukodystrophy (HP:0002415)1.95760729
138Cerebral inclusion bodies (HP:0100314)1.95713609
1393-Methylglutaconic aciduria (HP:0003535)1.93800214
140Urinary urgency (HP:0000012)1.93504387
141Increased circulating renin level (HP:0000848)1.92903691
142Recurrent bacterial skin infections (HP:0005406)1.92273217
143Urinary bladder sphincter dysfunction (HP:0002839)1.92067461
144Neonatal onset (HP:0003623)1.91418337
145Lipid accumulation in hepatocytes (HP:0006561)1.91048991
146Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.90349900
147Progressive macrocephaly (HP:0004481)1.90127000
148Myoglobinuria (HP:0002913)1.89677464
149Abnormality of the corticospinal tract (HP:0002492)1.89495817
150Hemiplegia (HP:0002301)1.89473168
151Spastic tetraparesis (HP:0001285)1.88848508
152Gaze-evoked nystagmus (HP:0000640)1.88474338
153Abnormality of methionine metabolism (HP:0010901)1.86742573
154Abnormality of sulfur amino acid metabolism (HP:0004339)1.86656536
155Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.86520428
156Tetraplegia (HP:0002445)1.86439709
157Respiratory failure (HP:0002878)1.86278789
158Exertional dyspnea (HP:0002875)1.85617112
159Opisthotonus (HP:0002179)1.85508633
160Ragged-red muscle fibers (HP:0003200)1.85159941
161Broad-based gait (HP:0002136)1.84921415
162Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.82110701
163Joint swelling (HP:0001386)1.80591038
164Eczematoid dermatitis (HP:0000976)1.80291717
165Nuclear cataract (HP:0100018)1.78622341
166Abnormality of the heme biosynthetic pathway (HP:0010472)1.76927158
167Lactic acidosis (HP:0003128)1.76906323
168Dementia (HP:0000726)1.76869090
169Abnormal pupillary function (HP:0007686)1.75946318
170Paralysis (HP:0003470)1.74426178
171Retinal atrophy (HP:0001105)1.71040518
172Abnormality of renal resorption (HP:0011038)1.70057690
173Irritability (HP:0000737)1.69535245
174Glycosuria (HP:0003076)1.67660491

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.61391767
2RIPK43.31003705
3EPHA43.29591643
4NTRK33.28177337
5ERN12.98232343
6MAP3K92.83467557
7IRAK32.81127425
8TESK22.66945106
9VRK22.55457895
10MAP3K42.49756163
11PRKD32.42869799
12PINK12.36831570
13MINK12.29134462
14TESK12.26464390
15BCKDK2.23552898
16DAPK22.17627678
17MAP2K42.11744142
18TAOK22.08857537
19PAK62.05849414
20MAP2K72.02469262
21LMTK21.96015786
22MATK1.93912681
23MAP3K121.93790614
24KSR21.89054145
25PHKG11.83380783
26PHKG21.83380783
27TBK11.80325666
28OXSR11.76923506
29PIM21.74495292
30MARK11.71195753
31STK161.67420857
32CAMKK11.63321599
33ABL21.62156358
34STK381.61782751
35BLK1.60864465
36ARAF1.58328877
37SGK2231.53796183
38SGK4941.53796183
39NTRK11.49382396
40STK391.46381526
41WNK41.40743065
42NTRK21.40095308
43TYK21.39161098
44CDK191.37763303
45MUSK1.37607089
46UHMK11.33889254
47WNK11.24979333
48CDK51.23681411
49MYLK1.22844224
50PDK41.21530714
51PDK31.21530714
52PRKCG1.21175185
53GRK51.20425150
54GRK71.19903258
55IKBKB1.19621841
56NEK11.19155811
57TAOK31.19131206
58MAP2K31.17028868
59MAP3K31.16872976
60CSF1R1.12853940
61CASK1.10235608
62PRPF4B1.09324928
63LRRK21.08036303
64CAMK2G1.05197014
65CAMK2A1.04412073
66DAPK11.03589223
67FGR1.03527784
68EIF2AK11.01655696
69IRAK21.01394338
70PDK21.00573020
71PRKG20.98575514
72TYRO30.97759603
73KDR0.97698919
74PAK30.96782908
75MAP4K10.95312370
76IKBKE0.94428173
77BMX0.93870739
78TRIB30.93868392
79FES0.93523193
80PDPK10.92964825
81MAPKAPK30.92275867
82CAMK2B0.89843977
83PRKCH0.89599216
84CCNB10.89279341
85SGK20.88938559
86CAMK10.88695583
87PKN10.88651656
88NEK60.88599121
89LATS20.87553267
90ICK0.87123497
91MAP3K130.85728959
92SGK30.85494970
93DDR20.84166351
94STK110.84158168
95NME10.84086291
96DAPK30.83876202
97MAP2K60.82882273
98SYK0.80440295
99PTK2B0.80309787
100WNK30.79132239
101PDK10.78833010
102MAPK130.78070072
103CDC42BPA0.77854940
104ZAP700.77562445
105TNIK0.77405315
106LIMK10.76966871
107KSR10.76699170
108CAMK2D0.76004748
109IRAK40.73590063
110PRKCZ0.72896202
111CDK150.72420202
112CDK180.72217360
113CAMKK20.71068537
114ILK0.69191840
115SIK10.69130811
116CDK140.68798463
117PLK20.67689784
118ADRBK20.66528462
119JAK30.64748393
120MAP3K20.62975805
121BCR0.62894625
122MAP3K70.62648315
123LYN0.62463343
124MAPK150.60647611
125GRK60.60580171
126CSK0.60455796
127CDK11A0.59310887
128TNK20.59208055
129TAOK10.58375838
130OBSCN0.58130390
131MAP3K50.57672922
132CAMK40.56364178
133MAP3K10.56005145
134PRKCE0.55283344
135ROCK20.54307003
136AKT30.53528536
137RET0.53433043
138VRK10.53394615
139PAK10.51765417
140PRKCD0.51302321
141MAPK120.51123092
142BRAF0.50869643
143SGK10.50853003
144PRKACG0.50845296
145RPS6KA30.50244187
146RIPK10.50115630
147MAP3K110.50022987
148ROCK10.49772751
149BRSK10.48877976
150PRKAA10.48073160
151CSNK1G20.47581059
152KIT0.46166231
153JAK20.42669420
154TGFBR20.42123701
155DYRK1B0.39445791
156SMG10.38027184
157PRKCA0.36286911
158CAMK1D0.35604816
159BTK0.35543487
160FYN0.34914691
161SCYL20.34793185

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.79159579
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.31785591
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.74656842
4Other glycan degradation_Homo sapiens_hsa005112.71847312
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.47802346
6Arginine biosynthesis_Homo sapiens_hsa002202.36116072
7Lysosome_Homo sapiens_hsa041422.28210849
8Butanoate metabolism_Homo sapiens_hsa006502.25131529
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.24377752
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.21489154
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.15285154
12Staphylococcus aureus infection_Homo sapiens_hsa051502.13480182
13Synaptic vesicle cycle_Homo sapiens_hsa047211.99664695
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.98282224
15Propanoate metabolism_Homo sapiens_hsa006401.97257587
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94946394
17Ribosome_Homo sapiens_hsa030101.94800962
18Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.89432279
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.85323913
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.83289212
21Fatty acid degradation_Homo sapiens_hsa000711.80477613
22Nicotine addiction_Homo sapiens_hsa050331.77682117
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69952435
24Fatty acid metabolism_Homo sapiens_hsa012121.65408347
25GABAergic synapse_Homo sapiens_hsa047271.64583994
26Glutathione metabolism_Homo sapiens_hsa004801.58493845
27Tryptophan metabolism_Homo sapiens_hsa003801.58493681
28Sulfur relay system_Homo sapiens_hsa041221.55535515
29Fatty acid elongation_Homo sapiens_hsa000621.55445429
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.54787019
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.51979538
32Rheumatoid arthritis_Homo sapiens_hsa053231.51546712
33Pyruvate metabolism_Homo sapiens_hsa006201.48691076
34Bile secretion_Homo sapiens_hsa049761.48550309
35Cardiac muscle contraction_Homo sapiens_hsa042601.39688741
36Mineral absorption_Homo sapiens_hsa049781.34590157
37Peroxisome_Homo sapiens_hsa041461.34176285
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.33573414
39Oxidative phosphorylation_Homo sapiens_hsa001901.31687943
40Circadian entrainment_Homo sapiens_hsa047131.29413258
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28014230
42Pertussis_Homo sapiens_hsa051331.27659100
43Proteasome_Homo sapiens_hsa030501.23966733
44Carbon metabolism_Homo sapiens_hsa012001.23608668
45Glutamatergic synapse_Homo sapiens_hsa047241.22891387
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.22245130
47PPAR signaling pathway_Homo sapiens_hsa033201.19263407
48Parkinsons disease_Homo sapiens_hsa050121.17736416
49beta-Alanine metabolism_Homo sapiens_hsa004101.17124842
50Galactose metabolism_Homo sapiens_hsa000521.15313514
51Olfactory transduction_Homo sapiens_hsa047401.14575902
52Vibrio cholerae infection_Homo sapiens_hsa051101.13230112
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.12023549
54Morphine addiction_Homo sapiens_hsa050321.10371531
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08258241
56Arachidonic acid metabolism_Homo sapiens_hsa005901.05605081
57Biosynthesis of amino acids_Homo sapiens_hsa012301.04343488
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.03907054
59SNARE interactions in vesicular transport_Homo sapiens_hsa041301.03561469
60Pentose phosphate pathway_Homo sapiens_hsa000301.03541434
61Phenylalanine metabolism_Homo sapiens_hsa003601.02691428
62Amphetamine addiction_Homo sapiens_hsa050311.01477774
63Salivary secretion_Homo sapiens_hsa049700.99953687
64Insulin secretion_Homo sapiens_hsa049110.99402617
65Caffeine metabolism_Homo sapiens_hsa002320.97257254
66Long-term potentiation_Homo sapiens_hsa047200.97038094
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96296624
68Folate biosynthesis_Homo sapiens_hsa007900.95729747
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.94416574
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.93301561
71Sulfur metabolism_Homo sapiens_hsa009200.92794533
72Complement and coagulation cascades_Homo sapiens_hsa046100.91823205
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91736338
74Gastric acid secretion_Homo sapiens_hsa049710.91516828
75Histidine metabolism_Homo sapiens_hsa003400.91153652
76Alzheimers disease_Homo sapiens_hsa050100.90746398
77Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.90617565
78Collecting duct acid secretion_Homo sapiens_hsa049660.90148040
79Dopaminergic synapse_Homo sapiens_hsa047280.85528339
80Tyrosine metabolism_Homo sapiens_hsa003500.85333472
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84957674
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83477294
83Tuberculosis_Homo sapiens_hsa051520.80856330
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80355785
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79261185
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79145729
87Osteoclast differentiation_Homo sapiens_hsa043800.79048775
88Chemical carcinogenesis_Homo sapiens_hsa052040.78882759
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.77499411
90Phagosome_Homo sapiens_hsa041450.77442249
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76132097
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75687466
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75267375
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74338507
95Fatty acid biosynthesis_Homo sapiens_hsa000610.73784169
96Arginine and proline metabolism_Homo sapiens_hsa003300.73075722
97Cholinergic synapse_Homo sapiens_hsa047250.72519703
98Vitamin B6 metabolism_Homo sapiens_hsa007500.72260910
99Leishmaniasis_Homo sapiens_hsa051400.70966916
100Taste transduction_Homo sapiens_hsa047420.68649540
101Calcium signaling pathway_Homo sapiens_hsa040200.67614486
102Cocaine addiction_Homo sapiens_hsa050300.62243625
103Malaria_Homo sapiens_hsa051440.60425599
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59691108
105Starch and sucrose metabolism_Homo sapiens_hsa005000.59653848
106Salmonella infection_Homo sapiens_hsa051320.58466948
107Legionellosis_Homo sapiens_hsa051340.57806896
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57649088
109Renin secretion_Homo sapiens_hsa049240.57421298
110Glycerolipid metabolism_Homo sapiens_hsa005610.56503100
111Huntingtons disease_Homo sapiens_hsa050160.56330850
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55471447
113Asthma_Homo sapiens_hsa053100.54861837
114Serotonergic synapse_Homo sapiens_hsa047260.54479923
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54207438
116Steroid biosynthesis_Homo sapiens_hsa001000.52292892
117Oxytocin signaling pathway_Homo sapiens_hsa049210.52018644
118Retinol metabolism_Homo sapiens_hsa008300.51534179
119ABC transporters_Homo sapiens_hsa020100.49557646
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48844706
121cAMP signaling pathway_Homo sapiens_hsa040240.48724598
122Long-term depression_Homo sapiens_hsa047300.47715119
123Prion diseases_Homo sapiens_hsa050200.46193141
124African trypanosomiasis_Homo sapiens_hsa051430.44649910
125Dilated cardiomyopathy_Homo sapiens_hsa054140.42580571
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41650936
127Fat digestion and absorption_Homo sapiens_hsa049750.41170867
128Glucagon signaling pathway_Homo sapiens_hsa049220.39843574
129Type II diabetes mellitus_Homo sapiens_hsa049300.39622100
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39465005
131Gap junction_Homo sapiens_hsa045400.38857485
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.36968176
133Fructose and mannose metabolism_Homo sapiens_hsa000510.36578230
134Allograft rejection_Homo sapiens_hsa053300.36276063
135GnRH signaling pathway_Homo sapiens_hsa049120.35825485
136Metabolic pathways_Homo sapiens_hsa011000.34145795
137Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33203714
138Vascular smooth muscle contraction_Homo sapiens_hsa042700.32884306
139Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30997561
140Hematopoietic cell lineage_Homo sapiens_hsa046400.26622716
141RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.26164686
142Adipocytokine signaling pathway_Homo sapiens_hsa049200.23902266
143Sphingolipid metabolism_Homo sapiens_hsa006000.23288355
144Intestinal immune network for IgA production_Homo sapiens_hsa046720.20504820

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »