PNKP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1leukocyte aggregation (GO:0070486)7.17190382
2disruption of cells of other organism involved in symbiotic interaction (GO:0051818)5.74885615
3killing of cells in other organism involved in symbiotic interaction (GO:0051883)5.74885615
4defense response to fungus (GO:0050832)5.56366573
5leukocyte migration involved in inflammatory response (GO:0002523)5.18966732
6neutrophil mediated immunity (GO:0002446)5.16850166
7respiratory burst (GO:0045730)4.81230885
8neutrophil activation involved in immune response (GO:0002283)4.79658991
9regulation of B cell receptor signaling pathway (GO:0050855)4.69405049
10Arp2/3 complex-mediated actin nucleation (GO:0034314)4.65700336
11response to fungus (GO:0009620)4.56335031
12pentose-phosphate shunt (GO:0006098)4.49007554
13killing of cells of other organism (GO:0031640)4.35377611
14disruption of cells of other organism (GO:0044364)4.35377611
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.28400401
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.28400401
17cellular extravasation (GO:0045123)4.27035629
18positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.26011992
19positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.15184598
20detection of bacterium (GO:0016045)4.12031029
21response to peptidoglycan (GO:0032494)4.09480170
22sequestering of metal ion (GO:0051238)4.07916269
23regulation of cytokine production involved in inflammatory response (GO:1900015)4.05295853
24negative regulation of phagocytosis (GO:0050765)4.02186519
25myeloid leukocyte mediated immunity (GO:0002444)4.01194778
26NADPH regeneration (GO:0006740)4.00855645
27negative regulation of erythrocyte differentiation (GO:0045647)3.93734243
28response to muramyl dipeptide (GO:0032495)3.93078694
29positive regulation of lamellipodium assembly (GO:0010592)3.91030474
30antigen processing and presentation of endogenous antigen (GO:0019883)3.89637565
31mannose metabolic process (GO:0006013)3.86510151
32positive regulation of gamma-delta T cell activation (GO:0046645)3.85900726
33thymic T cell selection (GO:0045061)3.83457591
34GDP-mannose metabolic process (GO:0019673)3.79815964
35detection of other organism (GO:0098543)3.70491638
36negative regulation of B cell apoptotic process (GO:0002903)3.51183768
37positive regulation of mast cell activation (GO:0033005)3.49112574
38purine deoxyribonucleotide catabolic process (GO:0009155)3.48532807
39cellular response to zinc ion (GO:0071294)3.47343137
40neutrophil activation (GO:0042119)3.40929378
41ribosomal small subunit assembly (GO:0000028)3.38830404
42positive regulation of histone deacetylation (GO:0031065)3.35581326
43production of molecular mediator involved in inflammatory response (GO:0002532)3.35225636
44regulation of B cell differentiation (GO:0045577)3.33900944
45leukocyte mediated cytotoxicity (GO:0001909)3.30880935
46sequestering of actin monomers (GO:0042989)3.29668050
47actin nucleation (GO:0045010)3.28446078
48viral transcription (GO:0019083)3.26278877
49negative regulation of growth of symbiont in host (GO:0044130)3.25316069
50negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.25316069
51modulation of growth of symbiont involved in interaction with host (GO:0044144)3.25316069
52regulation of growth of symbiont in host (GO:0044126)3.25316069
53modulation by virus of host process (GO:0019054)3.23120488
54negative thymic T cell selection (GO:0045060)3.20948622
55positive regulation of B cell differentiation (GO:0045579)3.16611242
56macrophage differentiation (GO:0030225)3.14279551
57negative regulation of innate immune response (GO:0045824)3.12954936
58regulation of interferon-beta biosynthetic process (GO:0045357)3.12919733
59modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.10180327
60modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.10180327
61positive regulation by organism of defense response of other organism involved in symbiotic interact3.10180327
62modulation by symbiont of host immune response (GO:0052553)3.10180327
63positive regulation by symbiont of host defense response (GO:0052509)3.10180327
64modulation by symbiont of host defense response (GO:0052031)3.10180327
65granulocyte activation (GO:0036230)3.07248519
66NIK/NF-kappaB signaling (GO:0038061)3.06355013
67T cell selection (GO:0045058)3.06257800
68pentose metabolic process (GO:0019321)3.05562337
69viral life cycle (GO:0019058)3.05190514
70regulation of mast cell activation (GO:0033003)3.05029209
71leukocyte degranulation (GO:0043299)3.05015945
72translational termination (GO:0006415)3.03537733
73regulation of mast cell degranulation (GO:0043304)3.01300150
74mitochondrial calcium ion transport (GO:0006851)3.00433237
75positive thymic T cell selection (GO:0045059)3.00274909
76leukotriene biosynthetic process (GO:0019370)2.99797088
77cellular response to virus (GO:0098586)2.99547021
78B cell receptor signaling pathway (GO:0050853)2.99498981
79positive regulation of protein deacetylation (GO:0090312)2.98160770
80positive T cell selection (GO:0043368)2.97828686
81immunoglobulin mediated immune response (GO:0016064)2.97761724
82positive regulation of lamellipodium organization (GO:1902745)2.97051752
83nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.96465990
84glucose catabolic process (GO:0006007)2.95273799
85cellular protein complex disassembly (GO:0043624)2.94744654
86antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.93805697
87phosphatidylglycerol biosynthetic process (GO:0006655)2.90892424
88defense response to protozoan (GO:0042832)2.90268159
89negative regulation of interleukin-8 production (GO:0032717)2.89667230
90regulation of gamma-delta T cell differentiation (GO:0045586)2.88853528
91negative T cell selection (GO:0043383)2.88125813
92positive regulation of antigen processing and presentation (GO:0002579)2.86755126
93negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.84851291
94negative regulation of cell killing (GO:0031342)2.84851291
95cell killing (GO:0001906)2.84774122
96regulation of type I interferon-mediated signaling pathway (GO:0060338)2.81877530
97leukotriene metabolic process (GO:0006691)2.81865935
98DNA strand elongation involved in DNA replication (GO:0006271)2.81383775
99UV protection (GO:0009650)2.80962582
100telomere maintenance via semi-conservative replication (GO:0032201)2.80644525
101regulation of gamma-delta T cell activation (GO:0046643)2.78620511
102leukocyte cell-cell adhesion (GO:0007159)2.78392046
103regulation of dendritic cell antigen processing and presentation (GO:0002604)2.78383710
104response to protozoan (GO:0001562)2.78010777
105regulation of monocyte differentiation (GO:0045655)2.77762343
106regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.76231758
107negative regulation of interleukin-12 production (GO:0032695)2.75822683
108regulation of antigen processing and presentation (GO:0002577)2.75207961
109regulation of myeloid leukocyte mediated immunity (GO:0002886)2.74992700
110SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.74783454
111translational elongation (GO:0006414)2.74641451
112regulation of mast cell activation involved in immune response (GO:0033006)2.74253247
113protein complex disassembly (GO:0043241)2.72995725
114positive regulation of mast cell activation involved in immune response (GO:0033008)2.72262885
115positive regulation of mast cell degranulation (GO:0043306)2.72262885
116reactive oxygen species biosynthetic process (GO:1903409)2.72262738
117cotranslational protein targeting to membrane (GO:0006613)2.70586535
118DNA strand elongation (GO:0022616)2.69769459
119protein targeting to ER (GO:0045047)2.68791124
120negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.65549528
121defense response to Gram-positive bacterium (GO:0050830)2.63611390
122negative regulation of lymphocyte mediated immunity (GO:0002707)2.63166483
123macrophage activation involved in immune response (GO:0002281)2.62536603
124response to type I interferon (GO:0034340)2.59906443
125chronic inflammatory response (GO:0002544)2.59853133
126cellular response to interleukin-4 (GO:0071353)2.59028481
127DNA deamination (GO:0045006)2.57822880
128regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.57771308
129protein localization to endoplasmic reticulum (GO:0070972)2.56478679
130modulation by symbiont of host cellular process (GO:0044068)2.56337911
131erythrocyte maturation (GO:0043249)2.55895706
132deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.55888213
133B cell mediated immunity (GO:0019724)2.55818595
134regulation of leukocyte degranulation (GO:0043300)2.55248198
135ribosomal small subunit biogenesis (GO:0042274)2.54595730
136positive regulation of Cdc42 GTPase activity (GO:0043089)2.54400034
137regulation of ARF GTPase activity (GO:0032312)2.54348667
138establishment of protein localization to endoplasmic reticulum (GO:0072599)2.53991286
139negative regulation of myeloid cell apoptotic process (GO:0033033)2.53611366
140NADP metabolic process (GO:0006739)2.52964801
141tolerance induction (GO:0002507)2.52940136
142pyrimidine nucleotide catabolic process (GO:0006244)2.51544692
143type I interferon signaling pathway (GO:0060337)2.51013768
144cellular response to type I interferon (GO:0071357)2.51013768
145negative regulation of leukocyte mediated immunity (GO:0002704)2.50257855
146regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.50097381
1473-UTR-mediated mRNA stabilization (GO:0070935)2.49610090
148response to interleukin-4 (GO:0070670)2.48670181
149mature B cell differentiation involved in immune response (GO:0002313)2.48532760
150morphogenesis of an endothelium (GO:0003159)2.47852767
151endothelial tube morphogenesis (GO:0061154)2.47852767
152neutrophil chemotaxis (GO:0030593)2.47442124
153response to interferon-beta (GO:0035456)2.47203547
154regulation of B cell apoptotic process (GO:0002902)2.45966527
155protein kinase C signaling (GO:0070528)2.45732329
156lipoxygenase pathway (GO:0019372)2.45371802
157Peyers patch development (GO:0048541)2.45186412
158myeloid cell activation involved in immune response (GO:0002275)2.43110542
159pinocytosis (GO:0006907)2.41608593
160mast cell activation (GO:0045576)2.40993593

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.12836556
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.28101253
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.98485249
4IRF8_21731497_ChIP-ChIP_J774_Mouse2.91707542
5* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.90613858
6MYB_21317192_ChIP-Seq_ERMYB_Mouse2.79581166
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.75533696
8* VDR_21846776_ChIP-Seq_THP-1_Human2.67556041
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.52055220
10SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.47002395
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.42711239
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.40036490
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.34579897
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.25945118
15* SPI1_23547873_ChIP-Seq_NB4_Human2.22315057
16MYC_22102868_ChIP-Seq_BL_Human2.19985943
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.19649010
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.17938439
19* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.15608477
20BRD4_27068464_Chip-Seq_AML-cells_Mouse2.13064893
21* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.09463641
22CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.08653062
23P68_20966046_ChIP-Seq_HELA_Human2.05859372
24KDM2B_26808549_Chip-Seq_SUP-B15_Human2.00061145
25STAT4_19710469_ChIP-ChIP_TH1__Mouse1.97611181
26EGR1_19374776_ChIP-ChIP_THP-1_Human1.96121614
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.92443041
28VDR_24763502_ChIP-Seq_THP-1_Human1.92313062
29* MAF_26560356_Chip-Seq_TH1_Human1.92087564
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91923812
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91179363
32SCL_19346495_ChIP-Seq_HPC-7_Human1.89731432
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.88532723
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.84218834
35ELF1_20517297_ChIP-Seq_JURKAT_Human1.82538786
36* KDM2B_26808549_Chip-Seq_DND41_Human1.82059378
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.81130812
38IRF8_27001747_Chip-Seq_BMDM_Mouse1.80126984
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.79179445
40TET1_21451524_ChIP-Seq_MESCs_Mouse1.76832810
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.76314341
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.75027476
43SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.73333481
44* UTX_26944678_Chip-Seq_JUKART_Human1.73325346
45RACK7_27058665_Chip-Seq_MCF-7_Human1.71915443
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.70949206
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.70422428
48JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.67417127
49SA1_27219007_Chip-Seq_ERYTHROID_Human1.67149454
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.66351767
51ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.65059146
52MYB_26560356_Chip-Seq_TH2_Human1.63614195
53* GABP_17652178_ChIP-ChIP_JURKAT_Human1.62654832
54RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62613570
55CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.59462102
56* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.56959874
57* SMC4_20622854_ChIP-Seq_HELA_Human1.55922494
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54894828
59CTCF_27219007_Chip-Seq_ERYTHROID_Human1.54621870
60* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.54038975
61MYB_26560356_Chip-Seq_TH1_Human1.52858057
62KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.52635971
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.52283954
64ETS1_20019798_ChIP-Seq_JURKAT_Human1.51593441
65FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.49206370
66VDR_23849224_ChIP-Seq_CD4+_Human1.46359912
67MAF_26560356_Chip-Seq_TH2_Human1.45881951
68E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.45313787
69PHF8_20622854_ChIP-Seq_HELA_Human1.44610424
70E2F1_20622854_ChIP-Seq_HELA_Human1.43624726
71EST1_17652178_ChIP-ChIP_JURKAT_Human1.42464901
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39864126
73IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38882922
74SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.38526238
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.38055560
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37586365
77* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.35539927
78KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35058430
79CTCF_26484167_Chip-Seq_Bcells_Mouse1.34600238
80EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34175066
81FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.32523080
82* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.32122674
83FOXP3_21729870_ChIP-Seq_TREG_Human1.29244046
84FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.29092784
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28803398
86PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28186744
87* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28170890
88CIITA_25753668_ChIP-Seq_RAJI_Human1.27883822
89NCOR1_26117541_ChIP-Seq_K562_Human1.27373464
90GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27290055
91STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.26012318
92RARB_24833708_ChIP-Seq_LIVER_Mouse1.25932056
93SPI1_23127762_ChIP-Seq_K562_Human1.25238372
94* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.25062955
95LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.24405063
96MYC_19079543_ChIP-ChIP_MESCs_Mouse1.24205534
97MYC_19030024_ChIP-ChIP_MESCs_Mouse1.23592554
98XRN2_22483619_ChIP-Seq_HELA_Human1.23406474
99CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22939189
100CTCF_21964334_Chip-Seq_Bcells_Human1.22445560
101YY1_22570637_ChIP-Seq_MALME-3M_Human1.22440565
102SRY_22984422_ChIP-ChIP_TESTIS_Rat1.21996577
103ELK3_25401928_ChIP-Seq_HUVEC_Human1.21247130
104CTCF_21964334_ChIP-Seq_BJAB-B_Human1.20659005
105* TCF7_22412390_ChIP-Seq_EML_Mouse1.20491536
106CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20391455
107SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19498217
108CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19097646
109PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.18736085
110* CREB1_26743006_Chip-Seq_LNCaP_Human1.17045186
111SA1_27219007_Chip-Seq_Bcells_Human1.16987239
112ERG_21242973_ChIP-ChIP_JURKAT_Human1.16200688
113CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15489650
114* FOXP1_21924763_ChIP-Seq_HESCs_Human1.14604023
115CTCF_18555785_ChIP-Seq_MESCs_Mouse1.14550769
116DCP1A_22483619_ChIP-Seq_HELA_Human1.13961159
117EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13694655
118* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12837666
119* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.12712461
120SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12150331
121PPARA_22158963_ChIP-Seq_LIVER_Mouse1.11910974
122VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11782164
123RARA_24833708_ChIP-Seq_LIVER_Mouse1.11592864
124CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11554866
125UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11516457
126* BCL6_27268052_Chip-Seq_Bcells_Human1.11167835
127SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.10442410
128CTCF_27219007_Chip-Seq_Bcells_Human1.10426896
129* CTCF_20526341_ChIP-Seq_ESCs_Human1.10128491
130* LXR_22292898_ChIP-Seq_THP-1_Human1.09336753
131PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09333951
132GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08888687
133P300_27268052_Chip-Seq_Bcells_Human1.07771285
134KDM2B_26808549_Chip-Seq_JURKAT_Human1.07234298
135SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05916886
136LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05737302
137* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.05293422
138GATA3_27048872_Chip-Seq_THYMUS_Human1.05129476
139PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04363675
140PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03926792
141FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03860336
142GATA1_19941827_ChIP-Seq_MEL_Mouse1.02978012
143MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02661384
144* GABP_19822575_ChIP-Seq_HepG2_Human1.02342458
145* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02012792
146NELFA_20434984_ChIP-Seq_ESCs_Mouse1.01511100
147NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01266771
148RUNX_20019798_ChIP-Seq_JUKART_Human1.01146631
149YY1_21170310_ChIP-Seq_MESCs_Mouse1.00174972
150PU_27001747_Chip-Seq_BMDM_Mouse0.99635251
151TFEB_21752829_ChIP-Seq_HELA_Human0.99578248
152GATA1_22025678_ChIP-Seq_K562_Human0.99160639
153* BCOR_27268052_Chip-Seq_Bcells_Human0.98007538

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.86729506
2MP0003436_decreased_susceptibility_to3.57151173
3MP0009785_altered_susceptibility_to3.42876202
4MP0001835_abnormal_antigen_presentation3.30960065
5MP0009278_abnormal_bone_marrow2.80898849
6MP0000685_abnormal_immune_system2.77124907
7MP0002419_abnormal_innate_immunity2.73119168
8MP0005025_abnormal_response_to2.66628059
9MP0003724_increased_susceptibility_to2.60421418
10MP0001800_abnormal_humoral_immune2.53526951
11MP0005000_abnormal_immune_tolerance2.45988584
12MP0002420_abnormal_adaptive_immunity2.32891266
13MP0001819_abnormal_immune_cell2.31057827
14MP0002452_abnormal_antigen_presenting2.28694203
15MP0001790_abnormal_immune_system2.27100187
16MP0005387_immune_system_phenotype2.27100187
17MP0005671_abnormal_response_to2.25129252
18MP0002723_abnormal_immune_serum2.24133417
19MP0005397_hematopoietic_system_phenotyp2.21576059
20MP0001545_abnormal_hematopoietic_system2.21576059
21MP0001853_heart_inflammation2.15369234
22MP0002148_abnormal_hypersensitivity_rea2.08266820
23MP0002405_respiratory_system_inflammati2.06619673
24MP0001849_ear_inflammation2.02142086
25MP0002398_abnormal_bone_marrow2.01524239
26MP0003763_abnormal_thymus_physiology1.96267486
27MP0003806_abnormal_nucleotide_metabolis1.94548557
28MP0002396_abnormal_hematopoietic_system1.92477296
29MP0000716_abnormal_immune_system1.91888384
30MP0005464_abnormal_platelet_physiology1.91682517
31MP0009333_abnormal_splenocyte_physiolog1.89506869
32MP0000465_gastrointestinal_hemorrhage1.85398454
33MP0009840_abnormal_foam_cell1.84093425
34MP0000689_abnormal_spleen_morphology1.79939223
35MP0003191_abnormal_cellular_cholesterol1.77169793
36MP0001845_abnormal_inflammatory_respons1.75068583
37MP0002722_abnormal_immune_system1.72676189
38MP0000858_altered_metastatic_potential1.71239000
39MP0001533_abnormal_skeleton_physiology1.70304385
40MP0002429_abnormal_blood_cell1.69568956
41MP0005076_abnormal_cell_differentiation1.65205163
42MP0004808_abnormal_hematopoietic_stem1.64752723
43MP0003693_abnormal_embryo_hatching1.63191806
44MP0003656_abnormal_erythrocyte_physiolo1.61789132
45MP0005083_abnormal_biliary_tract1.58455991
46MP0002933_joint_inflammation1.53994271
47MP0001986_abnormal_taste_sensitivity1.48534576
48MP0001873_stomach_inflammation1.48314431
49MP0005360_urolithiasis1.48010080
50MP0003300_gastrointestinal_ulcer1.47087794
51MP0010155_abnormal_intestine_physiology1.46987156
52MP0002166_altered_tumor_susceptibility1.42676080
53MP0002653_abnormal_ependyma_morphology1.39549676
54MP0008469_abnormal_protein_level1.37745741
55MP0005058_abnormal_lysosome_morphology1.37456315
56MP0002138_abnormal_hepatobiliary_system1.35276783
57MP0000703_abnormal_thymus_morphology1.34440341
58MP0003705_abnormal_hypodermis_morpholog1.31624245
59MP0000343_altered_response_to1.31011530
60MP0004947_skin_inflammation1.30666736
61MP0003866_abnormal_defecation1.25849169
62MP0006082_CNS_inflammation1.25831581
63MP0003111_abnormal_nucleus_morphology1.22828125
64MP0002822_catalepsy1.22255883
65MP0009764_decreased_sensitivity_to1.20513886
66MP0004858_abnormal_nervous_system1.18835859
67MP0004185_abnormal_adipocyte_glucose1.16948816
68MP0002837_dystrophic_cardiac_calcinosis1.15018191
69MP0003878_abnormal_ear_physiology1.14968760
70MP0005377_hearing/vestibular/ear_phenot1.14968760
71MP0001764_abnormal_homeostasis1.13691709
72MP0003279_aneurysm1.12849060
73MP0002019_abnormal_tumor_incidence1.11258665
74MP0008995_early_reproductive_senescence1.10539985
75MP0005174_abnormal_tail_pigmentation1.09788443
76MP0010030_abnormal_orbit_morphology1.08941485
77MP0009763_increased_sensitivity_to1.06662601
78MP0005075_abnormal_melanosome_morpholog1.05772711
79MP0003183_abnormal_peptide_metabolism1.04833124
80MP0005167_abnormal_blood-brain_barrier1.04346868
81MP0000490_abnormal_crypts_of1.03794982
82MP0002132_abnormal_respiratory_system1.00598508
83MP0003186_abnormal_redox_activity0.97299179
84MP0003075_altered_response_to0.97046756
85MP0003077_abnormal_cell_cycle0.95407439
86MP0005390_skeleton_phenotype0.94480949
87MP0002006_tumorigenesis0.92550096
88MP0003448_altered_tumor_morphology0.91826401
89MP0002249_abnormal_larynx_morphology0.90491033
90MP0004510_myositis0.90229416
91MP0005023_abnormal_wound_healing0.89353980
92MP0008260_abnormal_autophagy0.88930711
93MP0001851_eye_inflammation0.88563422
94MP0001663_abnormal_digestive_system0.87370773
95MP0000015_abnormal_ear_pigmentation0.85337896
96MP0004957_abnormal_blastocyst_morpholog0.85088264
97MP0010307_abnormal_tumor_latency0.83360402
98MP0000678_abnormal_parathyroid_gland0.82919520
99MP0008873_increased_physiological_sensi0.82140737
100MP0000003_abnormal_adipose_tissue0.81751572
101MP0000609_abnormal_liver_physiology0.81727897
102MP0002254_reproductive_system_inflammat0.81576992
103MP0009931_abnormal_skin_appearance0.80995003
104MP0005310_abnormal_salivary_gland0.79685970
105MP0006036_abnormal_mitochondrial_physio0.79674595
106MP0003172_abnormal_lysosome_physiology0.76795706
107MP0000470_abnormal_stomach_morphology0.76529860
108MP0009384_cardiac_valve_regurgitation0.76419198
109MP0006035_abnormal_mitochondrial_morpho0.75970240
110MP0005381_digestive/alimentary_phenotyp0.75914870
111MP0010094_abnormal_chromosome_stability0.74293714
112MP0002998_abnormal_bone_remodeling0.74106604
113MP0000604_amyloidosis0.72812922
114MP0009765_abnormal_xenobiotic_induced0.72469996
115MP0005451_abnormal_body_composition0.72226615
116MP0004381_abnormal_hair_follicle0.71993748
117MP0003828_pulmonary_edema0.71081450
118MP0003566_abnormal_cell_adhesion0.70857582
119MP0003136_yellow_coat_color0.69838590
120MP0005501_abnormal_skin_physiology0.69384744
121MP0000598_abnormal_liver_morphology0.68408486
122MP0003453_abnormal_keratinocyte_physiol0.65910539
123MP0000313_abnormal_cell_death0.65792504
124MP0008058_abnormal_DNA_repair0.65590386
125MP0000249_abnormal_blood_vessel0.64893891
126MP0005375_adipose_tissue_phenotype0.64259977
127MP0003786_premature_aging0.62258490
128MP0005319_abnormal_enzyme/_coenzyme0.62224634
129MP0002970_abnormal_white_adipose0.61827483
130MP0005666_abnormal_adipose_tissue0.60402883

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.13005522
2Recurrent abscess formation (HP:0002722)6.04416283
3Recurrent gram-negative bacterial infections (HP:0005420)5.45667847
4Recurrent bacterial skin infections (HP:0005406)5.22867344
5Chronic obstructive pulmonary disease (HP:0006510)4.72515170
6Obstructive lung disease (HP:0006536)4.72515170
7Spontaneous hematomas (HP:0007420)4.49993951
8Agammaglobulinemia (HP:0004432)4.11614995
9Abnormality of macrophages (HP:0004311)4.02037349
10Elevated erythrocyte sedimentation rate (HP:0003565)4.01654438
11Recurrent fungal infections (HP:0002841)3.80241032
12Stomatitis (HP:0010280)3.78046358
13Recurrent skin infections (HP:0001581)3.72106638
14Myositis (HP:0100614)3.53753906
15Mediastinal lymphadenopathy (HP:0100721)3.50901664
16Cellulitis (HP:0100658)3.47217727
17Gingivitis (HP:0000230)3.43596917
18Meningitis (HP:0001287)3.43342015
19Colitis (HP:0002583)3.42527762
20Urticaria (HP:0001025)3.36107906
21Chronic otitis media (HP:0000389)3.30309020
22Broad face (HP:0000283)3.28379461
23Vacuolated lymphocytes (HP:0001922)3.21385400
24Abnormality of the nasal mucosa (HP:0000433)3.16970466
25IgM deficiency (HP:0002850)3.12004016
26Entropion (HP:0000621)3.11346930
27Poikiloderma (HP:0001029)3.11111349
28Cervical subluxation (HP:0003308)3.10981469
29Thrombocytosis (HP:0001894)3.00033359
30J-shaped sella turcica (HP:0002680)2.99584055
31Pustule (HP:0200039)2.98810151
32Recurrent viral infections (HP:0004429)2.90337808
33Epistaxis (HP:0000421)2.89088513
34Joint stiffness (HP:0001387)2.88167650
35Testicular atrophy (HP:0000029)2.75871710
36Petechiae (HP:0000967)2.74902346
37Abnormal delayed hypersensitivity skin test (HP:0002963)2.72280367
38Microcytic anemia (HP:0001935)2.71043571
39Recurrent cutaneous fungal infections (HP:0011370)2.64777531
40Chronic mucocutaneous candidiasis (HP:0002728)2.64777531
41Abnormality of T cell physiology (HP:0011840)2.63627439
42Abnormality of cells of the erythroid lineage (HP:0012130)2.63114134
43Reticulocytopenia (HP:0001896)2.62948636
44Eosinophilia (HP:0001880)2.62360470
45Granulocytopenia (HP:0001913)2.57845924
46Abnormal number of erythroid precursors (HP:0012131)2.56119622
47Vasculitis (HP:0002633)2.56073559
48Nasal polyposis (HP:0100582)2.53621039
49Gastrointestinal inflammation (HP:0004386)2.53319696
50Hemorrhage of the eye (HP:0011885)2.53074489
51Abnormality of T cells (HP:0002843)2.52854598
52Leukocytosis (HP:0001974)2.51727946
53Gingival bleeding (HP:0000225)2.50244921
54Dysostosis multiplex (HP:0000943)2.48642090
55Inflammation of the large intestine (HP:0002037)2.48632121
56Recurrent bronchitis (HP:0002837)2.48087117
57Hypertensive crisis (HP:0100735)2.46192731
58Abnormality of cells of the lymphoid lineage (HP:0012140)2.45704174
59Lymphopenia (HP:0001888)2.40903361
60Hemoptysis (HP:0002105)2.40491920
61Prolonged bleeding time (HP:0003010)2.40198484
62Abnormality of T cell number (HP:0011839)2.37576720
63Gastrointestinal infarctions (HP:0005244)2.37506112
64IgG deficiency (HP:0004315)2.36931735
65Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.36195499
66Chest pain (HP:0100749)2.35966571
67Thin bony cortex (HP:0002753)2.35011489
68Hepatosplenomegaly (HP:0001433)2.34648516
69Hematochezia (HP:0002573)2.34619199
70Biconcave vertebral bodies (HP:0004586)2.34002523
71Skin ulcer (HP:0200042)2.33817720
72T lymphocytopenia (HP:0005403)2.32978511
73Pulmonary embolism (HP:0002204)2.31560619
74Abnormality of eosinophils (HP:0001879)2.31542210
75Abnormality of polysaccharide metabolism (HP:0011012)2.30672810
76Abnormality of glycosaminoglycan metabolism (HP:0004371)2.30672810
77Abnormality of mucopolysaccharide metabolism (HP:0011020)2.30672810
78Generalized aminoaciduria (HP:0002909)2.28933892
79Microvesicular hepatic steatosis (HP:0001414)2.26124039
80Increased neuronal autofluorescent lipopigment (HP:0002074)2.25880541
81Osteomyelitis (HP:0002754)2.23951896
82Abnormality of lateral ventricle (HP:0030047)2.23754553
83Broad distal phalanx of finger (HP:0009836)2.23486988
84Seborrheic dermatitis (HP:0001051)2.23402809
85Increased cerebral lipofuscin (HP:0011813)2.21013049
86Optic neuritis (HP:0100653)2.19940328
87Retrobulbar optic neuritis (HP:0100654)2.19940328
88Abnormality of B cell number (HP:0010975)2.19529167
89B lymphocytopenia (HP:0010976)2.19529167
90Panhypogammaglobulinemia (HP:0003139)2.18271376
91Obstructive sleep apnea (HP:0002870)2.16582609
92Abnormal platelet function (HP:0011869)2.13610982
93Impaired platelet aggregation (HP:0003540)2.13610982
94Sepsis (HP:0100806)2.10605288
95Urinary glycosaminoglycan excretion (HP:0003541)2.09814670
96Mucopolysacchariduria (HP:0008155)2.09814670
97Abnormality of the columella (HP:0009929)2.08567912
98Recurrent sinusitis (HP:0011108)2.05932612
99Pallor (HP:0000980)2.05700668
100Intestinal fistula (HP:0100819)2.05487040
101Orchitis (HP:0100796)2.04811693
102Nonimmune hydrops fetalis (HP:0001790)2.03897725
103Aplastic anemia (HP:0001915)2.01786196
104Autoimmune thrombocytopenia (HP:0001973)2.00644721
105Rough bone trabeculation (HP:0100670)1.99979848
106Stridor (HP:0010307)1.99401612
107Periodontitis (HP:0000704)1.99080565
108Joint hemorrhage (HP:0005261)1.98822412
109Hypochromic anemia (HP:0001931)1.98300147
110Interstitial pulmonary disease (HP:0006530)1.96709408
111Abnormality of DNA repair (HP:0003254)1.96448423
112Recurrent pneumonia (HP:0006532)1.94905410
113Aplasia/Hypoplasia of the thymus (HP:0010515)1.94129493
114Severe visual impairment (HP:0001141)1.92987710
115Hypergammaglobulinemia (HP:0010702)1.92407213
116Cutaneous photosensitivity (HP:0000992)1.92240905
117Hypertriglyceridemia (HP:0002155)1.92140826
118Increased serum ferritin (HP:0003281)1.91461809
119Restrictive lung disease (HP:0002091)1.91427823
120Abnormality of small intestinal villus morphology (HP:0011472)1.90557326
121Villous atrophy (HP:0011473)1.90557326
122Self-mutilation (HP:0000742)1.90535995
123Neutropenia (HP:0001875)1.89445393
124Rib fusion (HP:0000902)1.89315847
125Easy fatigability (HP:0003388)1.89238428
126Thoracic kyphosis (HP:0002942)1.88348245
127Ulnar bowing (HP:0003031)1.88234431
128Respiratory difficulties (HP:0002880)1.87696068
129Verrucae (HP:0200043)1.87499688
130Papilloma (HP:0012740)1.87499688
131Increased IgE level (HP:0003212)1.87437364
132Skin rash (HP:0000988)1.87359199
133Severe combined immunodeficiency (HP:0004430)1.85773950
134Poor head control (HP:0002421)1.85089604
135Pulmonary infiltrates (HP:0002113)1.84977275
136Encephalitis (HP:0002383)1.84972874
137Combined immunodeficiency (HP:0005387)1.84384367
138Lymphoma (HP:0002665)1.83861009
139Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.83163552
140Polygenic inheritance (HP:0010982)1.82597260
141Abnormality of iron homeostasis (HP:0011031)1.82496302
142Cerebral palsy (HP:0100021)1.81288532
143Abnormal platelet volume (HP:0011876)1.80006039
144Recurrent lower respiratory tract infections (HP:0002783)1.78555402
145Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.78303100
146Vaginal fistula (HP:0004320)1.76563500
147Truncus arteriosus (HP:0001660)1.72644303
148Abnormal trabecular bone morphology (HP:0100671)1.71983360

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK3.55575883
2MAP4K13.41365215
3IRAK43.30430982
4TESK23.23387341
5BUB12.96117514
6ERN12.92431915
7SMG12.73877183
8SIK12.49940124
9TEC2.40949587
10KDR2.35377212
11BTK2.25854898
12CSK2.24904387
13VRK22.13692461
14STK102.08055309
15EPHB12.06730782
16NME22.03049458
17GRK61.98814601
18ZAP701.97069872
19PRPF4B1.86347100
20INSRR1.85480377
21TAOK11.83367539
22FES1.83016116
23TLK11.79185027
24CLK11.65553566
25MAP3K101.64934329
26WEE11.62500067
27MAP2K31.62203754
28LRRK21.60250151
29STK161.57563774
30MAPK151.55862416
31ITK1.51358953
32TBK11.51040346
33BCKDK1.45496114
34PKN21.44347162
35RIPK41.38228838
36NME11.35708245
37CDK121.34073880
38SYK1.33050970
39TYK21.32269431
40MAP3K121.32003957
41PRKD21.31746406
42TAOK21.31274761
43PAK41.29866134
44EIF2AK11.28471673
45IKBKE1.28280969
46HCK1.25685976
47EIF2AK31.24572792
48TXK1.22446904
49MST1R1.20937372
50RIPK11.17191619
51MARK21.14341835
52IRAK31.14156882
53MAP3K81.13051790
54KIT1.11133272
55MAP2K61.09609934
56FGR1.09335659
57SIK21.06248487
58LYN1.04392458
59MAP3K31.01577835
60NEK21.00963528
61LCK1.00530221
62TESK10.98358341
63ICK0.96085644
64CSF1R0.94196237
65MATK0.91545145
66MAP3K10.84968191
67TTN0.84257971
68RPS6KA40.82998090
69FGFR40.81586822
70BMX0.81148223
71STK40.80762985
72TGFBR20.80697173
73TRIB30.80401910
74HIPK20.79583355
75MAP3K110.79451369
76DYRK30.77309284
77PIM10.77015928
78MAPK40.75859225
79FLT30.75818383
80RPS6KA20.75395521
81MAPK110.75112755
82MAPK120.72349627
83MAP3K70.72012527
84PIM20.71732955
85EEF2K0.68628015
86TTK0.67832810
87TRPM70.67794140
88IKBKB0.67095647
89CDC42BPA0.66997209
90CDK80.64833857
91EPHA20.64833539
92MAP3K140.64701329
93MAP2K20.60840973
94JAK30.60468447
95CCNB10.58654212
96MTOR0.58344385
97CDK40.56935022
98MYLK0.55274299
99CDK90.54901549
100ARAF0.53475159
101CHUK0.52229549
102DAPK30.51964097
103ZAK0.51131596
104IRAK20.50562876
105PRKCI0.49906158
106PTK20.49374004
107LIMK10.47864355
108RPS6KB20.46477806
109MAPKAPK20.46452627
110CDK190.46426836
111PRKCD0.46131429
112ILK0.45436790
113STK240.45310946
114MARK30.44589249
115RPS6KA60.44026365
116MUSK0.43705286
117RPS6KA50.43467112
118CDK70.43004741
119JAK10.41978504
120ABL10.41876923
121PRKG20.41644537
122TAOK30.40214803
123MAPK70.39819261
124FYN0.39608760
125VRK10.39112750
126RPS6KL10.38313360
127RPS6KC10.38313360
128RPS6KA10.37988360
129JAK20.37945876
130CAMK1D0.37125560
131PDPK10.36896557
132MAP3K130.36709482
133ATR0.36216020
134PTK60.35528019
135TNK20.34611792
136DAPK10.32910804
137AURKA0.32343895
138PRKD10.29579848

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.24599484
2Ribosome_Homo sapiens_hsa030102.80428473
3Leishmaniasis_Homo sapiens_hsa051402.52630433
4Staphylococcus aureus infection_Homo sapiens_hsa051502.50843877
5Primary immunodeficiency_Homo sapiens_hsa053402.40151164
6Pentose phosphate pathway_Homo sapiens_hsa000302.27646554
7Mismatch repair_Homo sapiens_hsa034302.23872133
8Notch signaling pathway_Homo sapiens_hsa043302.04947247
9Base excision repair_Homo sapiens_hsa034101.98120144
10Sulfur relay system_Homo sapiens_hsa041221.85769821
11Autoimmune thyroid disease_Homo sapiens_hsa053201.73545308
12Proteasome_Homo sapiens_hsa030501.71383289
13Nucleotide excision repair_Homo sapiens_hsa034201.64316216
14B cell receptor signaling pathway_Homo sapiens_hsa046621.61668143
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.55771674
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.53083372
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52795894
18Vitamin B6 metabolism_Homo sapiens_hsa007501.48919753
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.48735259
20Leukocyte transendothelial migration_Homo sapiens_hsa046701.47249899
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.47186639
22Other glycan degradation_Homo sapiens_hsa005111.46409147
23Homologous recombination_Homo sapiens_hsa034401.44083138
24Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.42637800
25Shigellosis_Homo sapiens_hsa051311.41654918
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.39651360
27Chronic myeloid leukemia_Homo sapiens_hsa052201.39081180
28Osteoclast differentiation_Homo sapiens_hsa043801.34059606
29Caffeine metabolism_Homo sapiens_hsa002321.33597645
30Hematopoietic cell lineage_Homo sapiens_hsa046401.31615320
31Pyrimidine metabolism_Homo sapiens_hsa002401.31492293
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.31003936
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.30382801
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.27966220
35RNA polymerase_Homo sapiens_hsa030201.27861039
36Antigen processing and presentation_Homo sapiens_hsa046121.26943452
37Non-small cell lung cancer_Homo sapiens_hsa052231.22039281
38Measles_Homo sapiens_hsa051621.21711574
39Folate biosynthesis_Homo sapiens_hsa007901.17589420
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17489131
41Bladder cancer_Homo sapiens_hsa052191.17426490
42One carbon pool by folate_Homo sapiens_hsa006701.14588688
43Asthma_Homo sapiens_hsa053101.13548097
44VEGF signaling pathway_Homo sapiens_hsa043701.12819961
45Spliceosome_Homo sapiens_hsa030401.12088685
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11413511
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11149160
48Pertussis_Homo sapiens_hsa051331.06201572
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.05503719
50HTLV-I infection_Homo sapiens_hsa051661.05201562
51Type I diabetes mellitus_Homo sapiens_hsa049400.97053057
52Histidine metabolism_Homo sapiens_hsa003400.96958959
53Viral myocarditis_Homo sapiens_hsa054160.95966333
54Apoptosis_Homo sapiens_hsa042100.95761501
55p53 signaling pathway_Homo sapiens_hsa041150.94400090
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94353777
57Allograft rejection_Homo sapiens_hsa053300.94133971
58Glutathione metabolism_Homo sapiens_hsa004800.93264085
59Legionellosis_Homo sapiens_hsa051340.92854767
60Glycerophospholipid metabolism_Homo sapiens_hsa005640.92458009
61Non-homologous end-joining_Homo sapiens_hsa034500.91191365
62Herpes simplex infection_Homo sapiens_hsa051680.89084812
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87274407
64Hepatitis C_Homo sapiens_hsa051600.87134737
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.87088731
66TNF signaling pathway_Homo sapiens_hsa046680.86372643
67Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86339995
68Pancreatic cancer_Homo sapiens_hsa052120.85500446
69Carbon metabolism_Homo sapiens_hsa012000.85441713
70Toll-like receptor signaling pathway_Homo sapiens_hsa046200.85074726
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.84624218
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84484815
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.83587441
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82269349
75T cell receptor signaling pathway_Homo sapiens_hsa046600.81462475
76Epstein-Barr virus infection_Homo sapiens_hsa051690.81195658
77Tuberculosis_Homo sapiens_hsa051520.81174924
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.80412696
79Protein export_Homo sapiens_hsa030600.80360986
80Cell cycle_Homo sapiens_hsa041100.80358338
81Biosynthesis of amino acids_Homo sapiens_hsa012300.80248820
82Systemic lupus erythematosus_Homo sapiens_hsa053220.79756657
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78953409
84Lysosome_Homo sapiens_hsa041420.75796755
85Salmonella infection_Homo sapiens_hsa051320.75472700
86Complement and coagulation cascades_Homo sapiens_hsa046100.72891250
87N-Glycan biosynthesis_Homo sapiens_hsa005100.72101936
88Chemokine signaling pathway_Homo sapiens_hsa040620.70696418
89Fructose and mannose metabolism_Homo sapiens_hsa000510.68900335
90Acute myeloid leukemia_Homo sapiens_hsa052210.68709333
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67755513
92Oxidative phosphorylation_Homo sapiens_hsa001900.66938601
93Rheumatoid arthritis_Homo sapiens_hsa053230.65432819
94Toxoplasmosis_Homo sapiens_hsa051450.64993561
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64956626
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63523422
97Malaria_Homo sapiens_hsa051440.63413794
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63272483
99Graft-versus-host disease_Homo sapiens_hsa053320.62903723
100Hepatitis B_Homo sapiens_hsa051610.60458718
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58900137
102Huntingtons disease_Homo sapiens_hsa050160.58825990
103Influenza A_Homo sapiens_hsa051640.58791780
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58152581
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.57207455
106Phagosome_Homo sapiens_hsa041450.56740467
107Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56037454
108ABC transporters_Homo sapiens_hsa020100.55262668
109Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.54928508
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.54927670
111Fanconi anemia pathway_Homo sapiens_hsa034600.54705009
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54699315
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54193507
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.52222407
115Parkinsons disease_Homo sapiens_hsa050120.51251860
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.51199718
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50796520
118Endocytosis_Homo sapiens_hsa041440.50673293
119Platelet activation_Homo sapiens_hsa046110.50516206
120Tryptophan metabolism_Homo sapiens_hsa003800.50184318
121Viral carcinogenesis_Homo sapiens_hsa052030.49613747
122Galactose metabolism_Homo sapiens_hsa000520.49169683
123beta-Alanine metabolism_Homo sapiens_hsa004100.48754951
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45731281
125RNA transport_Homo sapiens_hsa030130.43756473
126Starch and sucrose metabolism_Homo sapiens_hsa005000.43554661
127Inositol phosphate metabolism_Homo sapiens_hsa005620.43191644
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42358196
129Small cell lung cancer_Homo sapiens_hsa052220.41667869
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39850731
131mTOR signaling pathway_Homo sapiens_hsa041500.39645521
132SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39187777
133Prolactin signaling pathway_Homo sapiens_hsa049170.37192126
134Lysine degradation_Homo sapiens_hsa003100.37139055
135Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34122911
136African trypanosomiasis_Homo sapiens_hsa051430.33159696
137Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30073664

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