PNLIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the lipase family of proteins. The encoded enzyme is secreted by the pancreas and hydrolyzes triglycerides in the small intestine, and is essential for the efficient digestion of dietary fats. Inhibition of the encoded enzyme may prevent high-fat diet-induced obesity in mice and result in weight loss in human patients with obesity. Mutations in this gene cause congenital pancreatic lipase deficiency, a rare disorder characterized by steatorrhea. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1transcytosis (GO:0045056)9.00517372
2sterol catabolic process (GO:0016127)7.77760587
3cholesterol catabolic process (GO:0006707)7.77760587
4cobalamin metabolic process (GO:0009235)7.23654996
5COPI coating of Golgi vesicle (GO:0048205)7.20282432
6Golgi transport vesicle coating (GO:0048200)7.20282432
7peptidyl-proline hydroxylation (GO:0019511)7.00025364
8phosphatidylinositol acyl-chain remodeling (GO:0036149)6.88228563
9polyketide metabolic process (GO:0030638)6.59328821
10doxorubicin metabolic process (GO:0044598)6.59328821
11daunorubicin metabolic process (GO:0044597)6.59328821
12phosphatidylglycerol acyl-chain remodeling (GO:0036148)6.58335164
13phosphatidylserine acyl-chain remodeling (GO:0036150)6.58012434
14negative regulation of digestive system process (GO:0060457)6.53374282
15glycolipid catabolic process (GO:0019377)6.37685150
16membrane lipid catabolic process (GO:0046466)6.28413529
17regulation of phospholipase A2 activity (GO:0032429)6.13842385
18regulation of keratinocyte differentiation (GO:0045616)6.07433796
19aminoglycoside antibiotic metabolic process (GO:0030647)6.01127352
20regulation of keratinocyte proliferation (GO:0010837)5.96139498
21fatty acid derivative transport (GO:1901571)5.94569504
22icosanoid transport (GO:0071715)5.94569504
23tetrapyrrole metabolic process (GO:0033013)5.84992405
24activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.72535462
25ceramide catabolic process (GO:0046514)5.71739201
26cysteine metabolic process (GO:0006534)5.65525871
27innate immune response in mucosa (GO:0002227)5.47467205
28positive regulation of nuclease activity (GO:0032075)5.46443746
29protein maturation by protein folding (GO:0022417)5.42995552
30protein hydroxylation (GO:0018126)5.40392487
31* intestinal absorption (GO:0050892)5.27395122
32valine metabolic process (GO:0006573)5.11320878
33proline biosynthetic process (GO:0006561)5.08426808
34endoplasmic reticulum unfolded protein response (GO:0030968)5.05409783
35regulation of nuclease activity (GO:0032069)4.96997794
36branched-chain amino acid catabolic process (GO:0009083)4.96893557
37response to endoplasmic reticulum stress (GO:0034976)4.92849258
38cellular response to unfolded protein (GO:0034620)4.90228253
39endocrine pancreas development (GO:0031018)4.74552322
40ER-nucleus signaling pathway (GO:0006984)4.69217614
41phospholipid catabolic process (GO:0009395)4.68929642
42phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.68181064
43cellular response to topologically incorrect protein (GO:0035967)4.64359767
44COPII vesicle coating (GO:0048208)4.60328220
45zinc ion transport (GO:0006829)4.55416426
46cellular modified amino acid catabolic process (GO:0042219)4.53146207
47phosphatidylserine metabolic process (GO:0006658)4.50441041
48branched-chain amino acid metabolic process (GO:0009081)4.48378851
49mucosal immune response (GO:0002385)4.45817974
50acute-phase response (GO:0006953)4.40807123
51ER overload response (GO:0006983)4.34811719
52regulation of acrosome reaction (GO:0060046)4.33304588
534-hydroxyproline metabolic process (GO:0019471)4.32316075
54intestinal epithelial cell development (GO:0060576)4.32120965
55mitochondrial calcium ion transport (GO:0006851)4.28598987
56retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.26077807
57maintenance of protein localization in organelle (GO:0072595)4.25796157
58signal peptide processing (GO:0006465)4.24243397
59negative regulation of epidermal cell differentiation (GO:0045605)4.17999831
60homocysteine metabolic process (GO:0050667)4.16573363
61water-soluble vitamin metabolic process (GO:0006767)4.15071402
62regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.13568455
63ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.08486791
64organ or tissue specific immune response (GO:0002251)4.06043855
65phosphatidylcholine acyl-chain remodeling (GO:0036151)4.00697626
66response to unfolded protein (GO:0006986)3.98294838
67steroid catabolic process (GO:0006706)3.88872468
68glutamine metabolic process (GO:0006541)3.87591432
69phosphatidic acid biosynthetic process (GO:0006654)3.84663694
70phosphatidic acid metabolic process (GO:0046473)3.84663694
71L-alpha-amino acid transmembrane transport (GO:1902475)3.82449525
72response to topologically incorrect protein (GO:0035966)3.81937658
73defense response to Gram-positive bacterium (GO:0050830)3.75811688
74positive regulation of heat generation (GO:0031652)3.75579973
75leukotriene biosynthetic process (GO:0019370)3.75444183
76alditol phosphate metabolic process (GO:0052646)3.74599113
77protein N-linked glycosylation via asparagine (GO:0018279)3.67432188
78peptidyl-asparagine modification (GO:0018196)3.65384633
79sphingolipid catabolic process (GO:0030149)3.64137437
80endothelial cell migration (GO:0043542)3.61959763
81negative regulation of epithelial cell differentiation (GO:0030857)3.59895952
82regulation of epidermal cell differentiation (GO:0045604)3.58763635
83aspartate family amino acid catabolic process (GO:0009068)3.58295528
84serine family amino acid biosynthetic process (GO:0009070)3.57085453
85coenzyme catabolic process (GO:0009109)3.56062511
86regulation of fever generation (GO:0031620)3.55859245
87leukotriene metabolic process (GO:0006691)3.51778760
88nucleotide-sugar biosynthetic process (GO:0009226)3.42340369
89neutrophil mediated immunity (GO:0002446)3.40628404
90multicellular organismal catabolic process (GO:0044243)3.40262778
91creatine metabolic process (GO:0006600)3.38390533
92protein N-linked glycosylation (GO:0006487)3.34435662
93progesterone metabolic process (GO:0042448)3.33637609
94antibacterial humoral response (GO:0019731)3.32121746
95positive regulation of wound healing (GO:0090303)3.31328147
96proline metabolic process (GO:0006560)3.29608033
97glycoside metabolic process (GO:0016137)3.29117453
98erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.25855990
99L-phenylalanine catabolic process (GO:0006559)3.25855990
100vesicle coating (GO:0006901)3.24192760
101negative regulation of hormone metabolic process (GO:0032351)3.24115167
102GDP-mannose metabolic process (GO:0019673)3.23908067
103positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.21875117
104mitochondrion distribution (GO:0048311)3.21662566
105multicellular organismal metabolic process (GO:0044236)3.20785194
106cell redox homeostasis (GO:0045454)3.18143616
107vitamin metabolic process (GO:0006766)3.16870223
108Golgi organization (GO:0007030)3.16021561
109primary alcohol catabolic process (GO:0034310)3.13895597
110phosphatidylglycerol metabolic process (GO:0046471)3.10257702
111pancreas development (GO:0031016)3.07792486
112antimicrobial humoral response (GO:0019730)3.06786767
113acute inflammatory response (GO:0002526)3.06434064
114negative regulation of epidermis development (GO:0045683)3.04242995
115* digestive system process (GO:0022600)3.02450824
116erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.02143329
117L-phenylalanine metabolic process (GO:0006558)3.02143329
118cholesterol metabolic process (GO:0008203)3.00481549
119extracellular matrix disassembly (GO:0022617)2.95305023
120regulation of calcium ion import (GO:0090279)2.95152656
121macroautophagy (GO:0016236)2.91273170
122maintenance of gastrointestinal epithelium (GO:0030277)2.90450705
123* sterol transport (GO:0015918)2.88980578
124* cholesterol transport (GO:0030301)2.88980578
125regulation of heat generation (GO:0031650)2.82901673
126membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.82279354
127UDP-N-acetylglucosamine metabolic process (GO:0006047)2.80632845
128arachidonic acid secretion (GO:0050482)2.79816216
129icosanoid secretion (GO:0032309)2.79816216
130retinal metabolic process (GO:0042574)2.78491131
131cellular response to cadmium ion (GO:0071276)2.77764512
132insulin-like growth factor receptor signaling pathway (GO:0048009)2.77527283
133regulation of digestive system process (GO:0044058)2.75048261
134L-serine metabolic process (GO:0006563)2.74454316
135regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)2.72913143
136biotin metabolic process (GO:0006768)2.72606174
137serine family amino acid metabolic process (GO:0009069)2.72594010
138regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.71192325
139sterol metabolic process (GO:0016125)2.70734570
140activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.69208737
141icosanoid biosynthetic process (GO:0046456)2.67183341
142fatty acid derivative biosynthetic process (GO:1901570)2.67183341
143glycine transport (GO:0015816)2.66929506
144regulation of oxidative stress-induced cell death (GO:1903201)2.65258155
145epithelial cell migration (GO:0010631)2.65039088
146alcohol catabolic process (GO:0046164)2.65034423
147regulation of triglyceride catabolic process (GO:0010896)2.63395378
148myeloid leukocyte mediated immunity (GO:0002444)2.60769093
149glandular epithelial cell differentiation (GO:0002067)2.60613151
150peptide catabolic process (GO:0043171)2.60225707
151calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.59594212
152polarized epithelial cell differentiation (GO:0030859)2.58104700
153cellular protein catabolic process (GO:0044257)2.57963872
154regulation of cholesterol homeostasis (GO:2000188)2.57435703
155long-chain fatty acid transport (GO:0015909)2.50477441
156cellular response to zinc ion (GO:0071294)2.45948787
157cellular glucuronidation (GO:0052695)2.39069750
158cellular zinc ion homeostasis (GO:0006882)2.38633577
159regulation of metalloenzyme activity (GO:0048552)2.37508489
160exocrine pancreas development (GO:0031017)15.7314984
161* digestion (GO:0007586)12.6572742
162protein retention in ER lumen (GO:0006621)12.2944510
163maintenance of protein localization in endoplasmic reticulum (GO:0035437)11.6836540
164* intestinal cholesterol absorption (GO:0030299)11.5312512

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.31493128
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.78088275
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.99055920
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.79369778
5GATA1_22025678_ChIP-Seq_K562_Human3.25862974
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.91487703
7ERG_21242973_ChIP-ChIP_JURKAT_Human2.77278808
8SOX2_27498859_Chip-Seq_STOMACH_Mouse2.76712496
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.68295196
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.67467159
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.55868929
12GATA4_25053715_ChIP-Seq_YYC3_Human2.54264989
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.45845749
14ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.39503043
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.18199237
16GATA6_25053715_ChIP-Seq_YYC3_Human2.11215097
17CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.10574265
18TCF4_18268006_ChIP-ChIP_LS174T_Human1.96463160
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.89315264
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.88655635
21FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.64387457
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61696855
23NFYA_21822215_ChIP-Seq_K562_Human1.58313052
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57997381
25ETV1_20927104_ChIP-Seq_GIST48_Human1.57187017
26HNFA_21074721_ChIP-Seq_CACO-2_Human1.55852137
27PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.54169518
28PHF8_20622853_ChIP-Seq_HELA_Human1.50097544
29CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.48076670
30PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.45334814
31CREB1_26743006_Chip-Seq_LNCaP_Human1.45181911
32GATA6_21074721_ChIP-Seq_CACO-2_Human1.44778830
33KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.44260335
34KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.44260335
35KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.44260335
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43550439
37CLOCK_20551151_ChIP-Seq_293T_Human1.42413956
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41920762
39FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.41784533
40RBPJ_21746931_ChIP-Seq_IB4_Human1.40477292
41GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.40333622
42CHD1_26751641_Chip-Seq_LNCaP_Human1.40037435
43* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.39842869
44CBX2_22325352_ChIP-Seq_293T-Rex_Human1.39356620
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.37192978
46FOXA2_19822575_ChIP-Seq_HepG2_Human1.36329143
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35687782
48FOXO3_23340844_ChIP-Seq_DLD1_Human1.34495739
49CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.33497670
50FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.32244231
51AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.30467029
52FOXA1_25552417_ChIP-Seq_VCAP_Human1.30276651
53SOX2_20726797_ChIP-Seq_SW620_Human1.28325834
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.27472113
55NFYB_21822215_ChIP-Seq_K562_Human1.27038100
56TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26833580
57* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22145462
58JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21907909
59JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21501026
60CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21485764
61PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.21278611
62HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.19042369
63P63_26484246_Chip-Seq_KERATINOCYTES_Human1.17747221
64FOXH1_21741376_ChIP-Seq_ESCs_Human1.16256046
65EGR1_19032775_ChIP-ChIP_M12_Human1.16078527
66FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.14869470
67RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14372660
68CDX2_20551321_ChIP-Seq_CACO-2_Human1.14276882
69SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14184536
70LXR_22292898_ChIP-Seq_THP-1_Human1.11807717
71ZNF274_21170338_ChIP-Seq_K562_Hela1.11578307
72ERG_20517297_ChIP-Seq_VCAP_Human1.11442743
73ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11388358
74RUNX1_27514584_Chip-Seq_MCF-7_Human1.11100626
75ATF3_27146783_Chip-Seq_COLON_Human1.09636021
76DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08268826
77FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.08094402
78TP63_22573176_ChIP-Seq_HFKS_Human1.07268498
79SA1_27219007_Chip-Seq_ERYTHROID_Human1.07075014
80PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06847450
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06692774
82EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05507045
83ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05027636
84P68_20966046_ChIP-Seq_HELA_Human1.04526567
85CJUN_26792858_Chip-Seq_BT549_Human1.03740895
86KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02597886
87TAF15_26573619_Chip-Seq_HEK293_Human1.02453320
88RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02356701
89SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01725473
90TP53_18474530_ChIP-ChIP_U2OS_Human1.01586077
91KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00873234
92TBL1_22424771_ChIP-Seq_293T_Human0.98663857
93TRIM28_21343339_ChIP-Seq_HEK293_Human0.98070495
94ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98061931
95CEBPB_22108803_ChIP-Seq_LS180_Human0.97835275
96GATA3_24758297_ChIP-Seq_MCF-7_Human0.97832806
97FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97194186
98SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96515596
99TBX20_22328084_ChIP-Seq_HEART_Mouse0.96399932
100TBX20_22080862_ChIP-Seq_HEART_Mouse0.96399932
101SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.95726156
102ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93855075
103FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.93806278
104* ESET_19884257_ChIP-Seq_ESCs_Mouse0.93564252
105DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92483073
106NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.91103601
107KLF4_19829295_ChIP-Seq_ESCs_Human0.90196376
108ERA_21632823_ChIP-Seq_H3396_Human0.90136872
109GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90070079
110IRF1_19129219_ChIP-ChIP_H3396_Human0.89705574
111POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89327816
112CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88884188
113OCT4_20526341_ChIP-Seq_ESCs_Human0.87764813
114CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.87679203
115PPAR_26484153_Chip-Seq_NCI-H1993_Human0.87627523
116GATA3_21867929_ChIP-Seq_CD8_Mouse0.87615295
117GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.87126717
118CDX2_22108803_ChIP-Seq_LS180_Human0.87045432
119* CBP_21632823_ChIP-Seq_H3396_Human0.86971842
120RACK7_27058665_Chip-Seq_MCF-7_Human0.86837820
121SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86731363
122TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86370979
123SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.86175179
124SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.86175179
125TAF2_19829295_ChIP-Seq_ESCs_Human0.86017913
126KDM2B_26808549_Chip-Seq_K562_Human0.85727749
127SMAD4_21741376_ChIP-Seq_EPCs_Human0.85626887
128ELK4_26923725_Chip-Seq_MESODERM_Mouse0.85396411
129NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.85096961
130CTCF_27219007_Chip-Seq_Bcells_Human0.82251370
131GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.81998405
132BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.81474196
133GATA1_19941826_ChIP-Seq_K562_Human0.81443896
134PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.81020396
135P300_19829295_ChIP-Seq_ESCs_Human0.78911418
136NFIB_24661679_ChIP-Seq_LUNG_Mouse0.78877402
137ETV2_25802403_ChIP-Seq_MESCs_Mouse0.78519846
138SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78392424
139KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.77352854
140P53_21459846_ChIP-Seq_SAOS-2_Human0.76848531
141CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.76538963
142FOXA1_27270436_Chip-Seq_PROSTATE_Human0.76214556
143FOXA1_25329375_ChIP-Seq_VCAP_Human0.76214556
144PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.76174949
145FOXM1_26456572_ChIP-Seq_MCF-7_Human0.75874264
146LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.75553604
147TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.75167013
148EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.75047383
149FOXH1_21741376_ChIP-Seq_EPCs_Human0.74529233
150KLF5_25053715_ChIP-Seq_YYC3_Human0.74251967
151HTT_18923047_ChIP-ChIP_STHdh_Human0.74222924
152LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.73197621
153BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73024446
154FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.72894482
155NANOG_21062744_ChIP-ChIP_HESCs_Human0.72491851
156NANOG_19829295_ChIP-Seq_ESCs_Human0.71512713

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract9.63752545
2* MP0001666_abnormal_nutrient_absorption8.25460542
3MP0005220_abnormal_exocrine_pancreas6.82028942
4MP0005084_abnormal_gallbladder_morpholo5.27333663
5* MP0005365_abnormal_bile_salt4.48754930
6MP0005085_abnormal_gallbladder_physiolo3.57755845
7MP0002693_abnormal_pancreas_physiology3.48481808
8MP0002138_abnormal_hepatobiliary_system3.14836665
9* MP0003868_abnormal_feces_composition2.66127120
10MP0002139_abnormal_hepatobiliary_system2.58262917
11MP0001944_abnormal_pancreas_morphology2.58084488
12MP0001664_abnormal_digestion2.40432773
13MP0004264_abnormal_extraembryonic_tissu2.22671351
14MP0003252_abnormal_bile_duct2.07663080
15MP0003705_abnormal_hypodermis_morpholog2.04444750
16MP0002132_abnormal_respiratory_system1.92050202
17MP0002163_abnormal_gland_morphology1.88445717
18MP0002928_abnormal_bile_duct1.85169036
19MP0010234_abnormal_vibrissa_follicle1.82356341
20* MP0003959_abnormal_lean_body1.69848009
21MP0004233_abnormal_muscle_weight1.44803717
22MP0003283_abnormal_digestive_organ1.44312463
23MP0003300_gastrointestinal_ulcer1.43813596
24MP0003638_abnormal_response/metabolism_1.39887993
25MP0005165_increased_susceptibility_to1.37734273
26MP0008004_abnormal_stomach_pH1.33751524
27MP0009780_abnormal_chondrocyte_physiolo1.32124965
28* MP0005448_abnormal_energy_balance1.29488812
29* MP0002078_abnormal_glucose_homeostasis1.28716837
30* MP0002118_abnormal_lipid_homeostasis1.26244235
31MP0005379_endocrine/exocrine_gland_phen1.24032626
32MP0003045_fibrosis1.19364135
33MP0000003_abnormal_adipose_tissue1.18654002
34MP0008961_abnormal_basal_metabolism1.14288667
35MP0005332_abnormal_amino_acid1.13715459
36MP0002277_abnormal_respiratory_mucosa1.08425654
37MP0002877_abnormal_melanocyte_morpholog1.04293195
38MP0000470_abnormal_stomach_morphology1.03842732
39MP0003011_delayed_dark_adaptation0.99664149
40MP0009840_abnormal_foam_cell0.99323106
41MP0005535_abnormal_body_temperature0.98823977
42MP0006054_spinal_hemorrhage0.98265347
43MP0009643_abnormal_urine_homeostasis0.97433882
44MP0008789_abnormal_olfactory_epithelium0.95264608
45MP0005408_hypopigmentation0.95079146
46MP0000613_abnormal_salivary_gland0.93390242
47* MP0003953_abnormal_hormone_level0.87150988
48MP0004043_abnormal_pH_regulation0.86082955
49MP0004019_abnormal_vitamin_homeostasis0.83969230
50MP0010352_gastrointestinal_tract_polyps0.82894179
51MP0010678_abnormal_skin_adnexa0.79059592
52MP0005058_abnormal_lysosome_morphology0.78000995
53MP0009384_cardiac_valve_regurgitation0.77490387
54MP0003950_abnormal_plasma_membrane0.77389315
55MP0005499_abnormal_olfactory_system0.75860587
56MP0005394_taste/olfaction_phenotype0.75860587
57MP0003866_abnormal_defecation0.75123094
58MP0003195_calcinosis0.73644613
59MP0003183_abnormal_peptide_metabolism0.71453199
60MP0005451_abnormal_body_composition0.70136760
61MP0008872_abnormal_physiological_respon0.70112238
62MP0002970_abnormal_white_adipose0.69966327
63MP0002896_abnormal_bone_mineralization0.69080843
64MP0002909_abnormal_adrenal_gland0.66746912
65MP0004185_abnormal_adipocyte_glucose0.66210165
66MP0003879_abnormal_hair_cell0.64838199
67MP0000013_abnormal_adipose_tissue0.63799869
68MP0003656_abnormal_erythrocyte_physiolo0.62722420
69MP0008875_abnormal_xenobiotic_pharmacok0.62228813
70MP0005375_adipose_tissue_phenotype0.61741113
71MP0000490_abnormal_crypts_of0.59401894
72MP0000609_abnormal_liver_physiology0.59162330
73MP0003566_abnormal_cell_adhesion0.58765187
74MP0010329_abnormal_lipoprotein_level0.57150774
75MP0008438_abnormal_cutaneous_collagen0.56733226
76MP0001731_abnormal_postnatal_growth0.56061891
77MP0010386_abnormal_urinary_bladder0.55983917
78MP0001873_stomach_inflammation0.55205176
79MP0001502_abnormal_circadian_rhythm0.53130125
80MP0005187_abnormal_penis_morphology0.52680749
81MP0005377_hearing/vestibular/ear_phenot0.52334234
82MP0003878_abnormal_ear_physiology0.52334234
83MP0002234_abnormal_pharynx_morphology0.52330200
84MP0006036_abnormal_mitochondrial_physio0.51434875
85MP0003806_abnormal_nucleotide_metabolis0.50980262
86MP0001663_abnormal_digestive_system0.49681281
87* MP0000598_abnormal_liver_morphology0.48164146
88MP0009703_decreased_birth_body0.47340912
89MP0003943_abnormal_hepatobiliary_system0.47130920
90* MP0005452_abnormal_adipose_tissue0.46923638
91MP0005381_digestive/alimentary_phenotyp0.46447099
92MP0002876_abnormal_thyroid_physiology0.46315025
93MP0001501_abnormal_sleep_pattern0.46298727
94MP0003172_abnormal_lysosome_physiology0.45164203
95MP0000538_abnormal_urinary_bladder0.43666919
96MP0009765_abnormal_xenobiotic_induced0.43173949
97MP0003795_abnormal_bone_structure0.42696425
98MP0002098_abnormal_vibrissa_morphology0.42457895
99MP0001765_abnormal_ion_homeostasis0.42222270
100MP0005410_abnormal_fertilization0.41627528
101MP0005334_abnormal_fat_pad0.41558480
102MP0001764_abnormal_homeostasis0.41003613
103MP0002069_abnormal_eating/drinking_beha0.39862688
104MP0001845_abnormal_inflammatory_respons0.39018661
105MP0000371_diluted_coat_color0.37971244
106MP0008469_abnormal_protein_level0.37227796
107MP0005319_abnormal_enzyme/_coenzyme0.37126022
108MP0005360_urolithiasis0.36564834
109MP0005166_decreased_susceptibility_to0.36412464
110MP0002060_abnormal_skin_morphology0.36218878
111MP0003091_abnormal_cell_migration0.35971534
112MP0002089_abnormal_postnatal_growth/wei0.34795277
113MP0002136_abnormal_kidney_physiology0.34546235
114MP0000678_abnormal_parathyroid_gland0.34076546
115* MP0009642_abnormal_blood_homeostasis0.33139600
116MP0004272_abnormal_basement_membrane0.32908814
117MP0001485_abnormal_pinna_reflex0.32781616
118MP0003329_amyloid_beta_deposits0.32741912
119MP0002822_catalepsy0.32631150
120MP0001756_abnormal_urination0.32566404
121MP0000367_abnormal_coat/_hair0.32137542
122MP0002796_impaired_skin_barrier0.31058875
123MP0003186_abnormal_redox_activity0.30860831
124MP0000377_abnormal_hair_follicle0.30736974
125MP0003436_decreased_susceptibility_to0.30536473
126MP0000750_abnormal_muscle_regeneration0.30045761
127MP0002168_other_aberrant_phenotype0.29681805
128MP0009763_increased_sensitivity_to0.29589907
129MP0005248_abnormal_Harderian_gland0.29570304
130MP0000462_abnormal_digestive_system0.29526392
131MP0005636_abnormal_mineral_homeostasis0.29417974
132MP0002837_dystrophic_cardiac_calcinosis0.28676200
133MP0005595_abnormal_vascular_smooth0.28104573
134MP0005395_other_phenotype0.25730105
135MP0000858_altered_metastatic_potential0.25222541
136MP0003941_abnormal_skin_development0.24753569

Predicted human phenotypes

RankGene SetZ-score
1Gout (HP:0001997)6.68227291
2Exocrine pancreatic insufficiency (HP:0001738)5.71772563
3Abnormal pancreas size (HP:0012094)5.46016959
4Decreased subcutaneous fat (HP:0001002)4.74505282
5Abnormality of the intrinsic pathway (HP:0010989)4.67136042
6Abnormality of the pleura (HP:0002103)4.62682524
7Abnormality of the pancreatic islet cells (HP:0006476)4.54677261
8Abnormality of endocrine pancreas physiology (HP:0012093)4.54677261
9Short chin (HP:0000331)4.54161113
10Tetraparesis (HP:0002273)4.52741621
11Hyperinsulinemic hypoglycemia (HP:0000825)4.32092053
12Type I diabetes mellitus (HP:0100651)4.30424558
13Ketoacidosis (HP:0001993)4.29172167
14Abnormality of subcutaneous fat tissue (HP:0001001)4.27651169
15Hypoglycemic seizures (HP:0002173)4.23275034
16Hypoglycemic coma (HP:0001325)4.17305782
17Ketosis (HP:0001946)3.85792830
18Hypoplasia of the pons (HP:0012110)3.78353944
19Pancreatitis (HP:0001733)3.71489431
20Maternal diabetes (HP:0009800)3.66598862
21Abnormality of aromatic amino acid family metabolism (HP:0004338)3.66220125
22Tubulointerstitial fibrosis (HP:0005576)3.60926981
23Ileus (HP:0002595)3.59510927
24Late onset (HP:0003584)3.59068670
25Abnormality of the pons (HP:0007361)3.51474012
26Rectal prolapse (HP:0002035)3.46924559
27* Fat malabsorption (HP:0002630)3.46304811
28* Steatorrhea (HP:0002570)3.45177274
29Vascular calcification (HP:0004934)3.42225871
30Male infertility (HP:0003251)3.41970815
31Hypoproteinemia (HP:0003075)3.38528284
32Hydroxyprolinuria (HP:0003080)3.33811900
33Abnormality of proline metabolism (HP:0010907)3.33811900
34Premature skin wrinkling (HP:0100678)3.29991943
35Carpal bone hypoplasia (HP:0001498)3.22883409
36Symptomatic seizures (HP:0011145)3.22309146
37Tubulointerstitial nephritis (HP:0001970)3.22275658
38Cortical dysplasia (HP:0002539)3.18795281
39Anal atresia (HP:0002023)3.12400497
40Hyperglycemia (HP:0003074)3.10727990
41Abnormality of the common coagulation pathway (HP:0010990)3.09806776
42Cardiovascular calcification (HP:0011915)3.00139433
43Hyperuricemia (HP:0002149)2.96047691
44Increased purine levels (HP:0004368)2.96047691
45Joint stiffness (HP:0001387)2.93482805
46Abnormal tarsal ossification (HP:0008369)2.75420731
47Abnormal sex determination (HP:0012244)2.71982545
48Sex reversal (HP:0012245)2.71982545
49Large for gestational age (HP:0001520)2.71429841
50Ventricular fibrillation (HP:0001663)2.67003381
51Abnormality of small intestinal villus morphology (HP:0011472)2.60783297
52Villous atrophy (HP:0011473)2.60783297
53Abnormality of glutamine family amino acid metabolism (HP:0010902)2.58586117
54Conjugated hyperbilirubinemia (HP:0002908)2.57989616
55Insulin-resistant diabetes mellitus (HP:0000831)2.57601168
56Congenital glaucoma (HP:0001087)2.57522737
57Long foot (HP:0001833)2.57093959
58Dysostosis multiplex (HP:0000943)2.55488362
59Pancreatic islet-cell hyperplasia (HP:0004510)2.54713774
60Hyperglycinemia (HP:0002154)2.51091444
61Esophageal varix (HP:0002040)2.50052498
62Unilateral renal agenesis (HP:0000122)2.49043630
63Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.48507924
64Hypoplasia of the odontoid process (HP:0003311)2.47247877
65Acute hepatic failure (HP:0006554)2.46050460
66Abnormality of sulfur amino acid metabolism (HP:0004339)2.46027500
67Small epiphyses (HP:0010585)2.44346090
68Abnormal biliary tract morphology (HP:0012440)2.42490585
69Hyperphosphatemia (HP:0002905)2.38960299
70Facial shape deformation (HP:0011334)2.34732977
71Potter facies (HP:0002009)2.34732977
72Type I transferrin isoform profile (HP:0003642)2.34287921
73Abnormality of purine metabolism (HP:0004352)2.31949937
74Abnormal protein glycosylation (HP:0012346)2.26515686
75Abnormal glycosylation (HP:0012345)2.26515686
76Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.26515686
77Abnormal protein N-linked glycosylation (HP:0012347)2.26515686
78Abnormality of the renal cortex (HP:0011035)2.26262990
79Reduced antithrombin III activity (HP:0001976)2.25539119
80Fatigue (HP:0012378)2.25340606
81Progressive muscle weakness (HP:0003323)2.23286409
82Ankyloglossia (HP:0010296)2.20549391
83Cortical visual impairment (HP:0100704)2.18384034
84Pectus carinatum (HP:0000768)2.18191190
85Hyperglycinuria (HP:0003108)2.16926816
86Urinary glycosaminoglycan excretion (HP:0003541)2.13774821
87Mucopolysacchariduria (HP:0008155)2.13774821
88Severe short stature (HP:0003510)2.13769574
89Barrel-shaped chest (HP:0001552)2.13319693
90Limb hypertonia (HP:0002509)2.12698505
91Popliteal pterygium (HP:0009756)2.12483363
92Hypsarrhythmia (HP:0002521)2.11789872
93Right ventricular cardiomyopathy (HP:0011663)2.10963637
94Abnormal foot bone ossification (HP:0010675)2.10011040
95Tubulointerstitial abnormality (HP:0001969)2.09081243
96Abnormality of the right ventricle (HP:0001707)2.09010660
97Type II lissencephaly (HP:0007260)2.08922594
98Prenatal maternal abnormality (HP:0002686)2.07835416
99Insulin resistance (HP:0000855)2.07698902
100Malnutrition (HP:0004395)2.04725362
101Prolonged QT interval (HP:0001657)2.04564603
102Abnormality of methionine metabolism (HP:0010901)2.03395592
103Hypoplasia of the uterus (HP:0000013)2.03363980
104EEG with generalized epileptiform discharges (HP:0011198)2.02375645
105Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.01880801
106Paraparesis (HP:0002385)2.01237480
107Abnormality of glycine metabolism (HP:0010895)2.00440940
108Abnormality of serine family amino acid metabolism (HP:0010894)2.00440940
109Azoospermia (HP:0000027)1.99793638
110Neonatal death (HP:0003811)1.99239195
111Lower limb hyperreflexia (HP:0002395)1.98871391
112Double outlet right ventricle (HP:0001719)1.98099903
113Congenital malformation of the right heart (HP:0011723)1.98099903
114Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.96287421
115Myocardial infarction (HP:0001658)1.95629063
116Abnormality of the odontoid process (HP:0003310)1.95000564
117Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93753782
118Epileptiform EEG discharges (HP:0011182)1.91799314
119Optic nerve hypoplasia (HP:0000609)1.90303972
120Flattened epiphyses (HP:0003071)1.88451936
121Abnormality of mucopolysaccharide metabolism (HP:0011020)1.87974762
122Abnormality of polysaccharide metabolism (HP:0011012)1.87974762
123Abnormality of glycosaminoglycan metabolism (HP:0004371)1.87974762
124Abdominal pain (HP:0002027)1.87842506
125Glucose intolerance (HP:0000833)1.87523274
126Intrahepatic cholestasis (HP:0001406)1.86043897
127Epiphyseal dysplasia (HP:0002656)1.84472102
128Tubular atrophy (HP:0000092)1.83651675
129Vacuolated lymphocytes (HP:0001922)1.83320190
130Abnormality of chloride homeostasis (HP:0011422)1.81130945
131Increased CSF protein (HP:0002922)1.71249239
132Abnormality of aspartate family amino acid metabolism (HP:0010899)1.68583802
133Cerebellar dysplasia (HP:0007033)1.65841489
134Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.63029758
135Vertebral compression fractures (HP:0002953)1.60798056
136Hypercalciuria (HP:0002150)1.60158090
137Stenosis of the external auditory canal (HP:0000402)1.50610991
138Increased circulating renin level (HP:0000848)1.49148509
139Glossoptosis (HP:0000162)1.48043735
140Goiter (HP:0000853)1.47852416
141Congenital, generalized hypertrichosis (HP:0004540)1.45680250
142Neoplasm of the pancreas (HP:0002894)1.42669548
143Mitral stenosis (HP:0001718)1.42606230
144Abnormal cartilage morphology (HP:0002763)1.40955985
145Dehydration (HP:0001944)1.38508533
146Abnormal spermatogenesis (HP:0008669)1.36749435
147Deformed sella turcica (HP:0002681)1.36090200
148Abnormality of the nasal septum (HP:0000419)1.34585518
149Portal hypertension (HP:0001409)1.29384080
150Bifid uvula (HP:0000193)1.26482090
151Abnormality of monocarboxylic acid metabolism (HP:0010996)1.25913876
152Hyperammonemia (HP:0001987)1.23523766
153Abnormal hemoglobin (HP:0011902)1.20978706
154Abnormality of the distal phalanges of the toes (HP:0010182)1.20818097
155Abnormality of fatty-acid metabolism (HP:0004359)1.20000127
156Renal tubular acidosis (HP:0001947)1.19255849
157Gowers sign (HP:0003391)1.18705716

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.86319711
2ERN14.65108690
3EIF2AK34.53886620
4EPHA24.51469621
5INSRR4.25806053
6MAP2K24.09243217
7TRIB33.25784834
8FRK3.18067470
9TAOK33.02957557
10PKN22.63111683
11MAP3K122.19277166
12MST1R2.16622494
13MAPK152.13295947
14IRAK32.11992649
15GRK11.90105682
16PRKG21.89564627
17MAPKAPK31.75727678
18SCYL21.70612382
19MAP2K11.70170892
20ZAP701.66506994
21MAP3K21.59904394
22STK161.48992281
23EIF2AK11.48381980
24WNK41.48078060
25PTK61.38881557
26DYRK1A1.36809470
27PAK21.36345683
28TBK11.29818591
29NLK1.29065291
30FLT31.22932960
31LATS11.20113520
32MST41.17976891
33TRPM71.16167500
34PDGFRB1.14902976
35PASK1.14120965
36BMPR1B1.05423650
37ERBB41.04665966
38SIK11.01921144
39CAMKK21.01669323
40PRKD31.00885520
41CAMKK10.97400590
42HIPK20.93808726
43MAP3K10.91767741
44IRAK20.91249758
45NME10.87550234
46PRKCH0.87089787
47DYRK1B0.86335188
48RET0.85488348
49STK240.83263829
50EEF2K0.82704432
51PDGFRA0.82253240
52STK38L0.81513641
53OXSR10.81191221
54RPS6KB20.76677328
55PIK3CA0.76642397
56PIK3CG0.76597278
57RIPK10.73203106
58MTOR0.70785145
59ACVR1B0.69381991
60FGFR40.68243395
61PIM20.68084249
62NTRK10.66744947
63DAPK20.65812509
64IRAK10.63738949
65TESK10.63040169
66MYLK0.62831660
67ROCK10.62258263
68EPHA30.61627848
69ERBB30.60771001
70MAP3K140.60223069
71EPHB10.59619228
72NME20.58504105
73FER0.58492138
74KSR20.55015464
75PRKCI0.54538079
76IRAK40.54163445
77PTK20.52578814
78PRKCZ0.50652500
79PDPK10.50473030
80JAK20.50297036
81DAPK10.49972573
82PDK20.49054848
83MAP3K50.48101713
84RPS6KB10.47768096
85STK390.47355811
86CDK190.46491129
87STK380.45218327
88MET0.44352447
89MAP2K60.44101429
90FGFR30.43037494
91PRKD10.42371883
92BCR0.41582456
93PRKD20.41199076
94LRRK20.40146987
95NEK60.39350914
96SGK30.39167698
97MAP3K70.36796603
98PDK10.36795105
99NTRK30.36593831
100MELK0.35393025
101DAPK30.34255117
102CDK80.34119886
103BMPR20.30836120
104CAMK1D0.30415676
105MAPK30.30180418
106UHMK10.29759183
107CDC42BPA0.27894993
108SGK20.26307905
109MAP3K40.25764845
110IGF1R0.25729637
111ILK0.25376244
112TSSK60.25288136
113GSK3A0.25107935
114ABL10.24907237
115PAK40.23854294
116PRKAA10.23707799
117MAP3K30.23607839
118PAK30.21897432
119JAK10.21672714
120PRKACB0.21321278
121FGFR20.21025470
122BMX0.20493524
123MAPK120.20351094
124SGK2230.19498327
125SGK4940.19498327
126STK30.19415561
127WNK10.19402419
128MAPK10.18846429
129TGFBR20.18357283
130LMTK20.18260364
131MAP3K90.18211761
132MUSK0.18134456
133PRKCA0.17956504
134RPS6KA10.16688242
135CSNK1A1L0.16062741
136CSNK1G20.16040914
137PRKCQ0.14712845
138RPS6KA30.14189415
139AKT10.13983650
140EGFR0.13573994
141TAOK20.13311463
142CSNK1A10.13271307
143CAMK1G0.13137100
144CSNK1G10.13033838
145PRKACA0.12483316
146MAP2K40.11438520
147CSNK1E0.11410380
148PRKCE0.10895966
149CHUK0.10657101
150ALK0.10552900
151NEK10.09752365
152CAMK40.09582420

Predicted pathways (KEGG)

RankGene SetZ-score
1* Pancreatic secretion_Homo sapiens_hsa049728.19405872
2Protein digestion and absorption_Homo sapiens_hsa049745.65178915
3Maturity onset diabetes of the young_Homo sapiens_hsa049505.00801696
4* Fat digestion and absorption_Homo sapiens_hsa049754.86494566
5Protein export_Homo sapiens_hsa030603.75467061
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.76651430
7Folate biosynthesis_Homo sapiens_hsa007902.60632002
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.07956175
9* Glycerolipid metabolism_Homo sapiens_hsa005612.00640009
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.97082217
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.96638708
12Steroid biosynthesis_Homo sapiens_hsa001001.93385693
13Renin-angiotensin system_Homo sapiens_hsa046141.54613556
14Propanoate metabolism_Homo sapiens_hsa006401.51022132
15Carbohydrate digestion and absorption_Homo sapiens_hsa049731.50624204
16Insulin secretion_Homo sapiens_hsa049111.35492255
17Starch and sucrose metabolism_Homo sapiens_hsa005001.19184259
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12635847
19N-Glycan biosynthesis_Homo sapiens_hsa005101.11732763
20Linoleic acid metabolism_Homo sapiens_hsa005911.07206135
21Sulfur metabolism_Homo sapiens_hsa009200.98826271
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97699731
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96577105
24Selenocompound metabolism_Homo sapiens_hsa004500.96373520
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94623375
26Arginine and proline metabolism_Homo sapiens_hsa003300.85353314
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84002690
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80584761
29Other glycan degradation_Homo sapiens_hsa005110.79507834
30Vibrio cholerae infection_Homo sapiens_hsa051100.78683777
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78671641
32Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76665474
33Influenza A_Homo sapiens_hsa051640.75175672
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73034813
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67251572
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67078813
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66724957
38Notch signaling pathway_Homo sapiens_hsa043300.64951923
39Biosynthesis of amino acids_Homo sapiens_hsa012300.63359821
40Glutathione metabolism_Homo sapiens_hsa004800.63314705
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62393036
42Vitamin B6 metabolism_Homo sapiens_hsa007500.60898771
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57556582
44Type II diabetes mellitus_Homo sapiens_hsa049300.56143447
45Steroid hormone biosynthesis_Homo sapiens_hsa001400.56069567
46Type I diabetes mellitus_Homo sapiens_hsa049400.51795605
47One carbon pool by folate_Homo sapiens_hsa006700.51520553
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51450699
49Chemical carcinogenesis_Homo sapiens_hsa052040.51269302
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51021025
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50753289
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.49447360
53Histidine metabolism_Homo sapiens_hsa003400.48053970
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46471395
55Legionellosis_Homo sapiens_hsa051340.46265061
56Lysosome_Homo sapiens_hsa041420.46157806
57Endometrial cancer_Homo sapiens_hsa052130.45016737
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44653313
59Tryptophan metabolism_Homo sapiens_hsa003800.43580730
60Fatty acid degradation_Homo sapiens_hsa000710.39982468
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.39694286
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39671832
63Insulin resistance_Homo sapiens_hsa049310.38751139
64Nitrogen metabolism_Homo sapiens_hsa009100.37897179
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36650891
66beta-Alanine metabolism_Homo sapiens_hsa004100.36367219
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35173198
68Regulation of autophagy_Homo sapiens_hsa041400.33487136
69Cocaine addiction_Homo sapiens_hsa050300.32819932
70Retinol metabolism_Homo sapiens_hsa008300.32636560
71VEGF signaling pathway_Homo sapiens_hsa043700.31699591
72mTOR signaling pathway_Homo sapiens_hsa041500.30372661
73Prostate cancer_Homo sapiens_hsa052150.28962643
74Arginine biosynthesis_Homo sapiens_hsa002200.28323032
75Sphingolipid metabolism_Homo sapiens_hsa006000.27731986
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27568667
77Pyruvate metabolism_Homo sapiens_hsa006200.25920398
78Mineral absorption_Homo sapiens_hsa049780.25104627
79Ether lipid metabolism_Homo sapiens_hsa005650.24093806
80Thyroid hormone synthesis_Homo sapiens_hsa049180.23932780
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22574974
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22357168
83Arachidonic acid metabolism_Homo sapiens_hsa005900.22267377
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.22048978
85Estrogen signaling pathway_Homo sapiens_hsa049150.20948986
86Fructose and mannose metabolism_Homo sapiens_hsa000510.19073339
87ABC transporters_Homo sapiens_hsa020100.18397034
88Tight junction_Homo sapiens_hsa045300.18351131
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.17791186
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.17451553
91Calcium signaling pathway_Homo sapiens_hsa040200.17226514
92Hepatitis C_Homo sapiens_hsa051600.15793867
93Toxoplasmosis_Homo sapiens_hsa051450.15497813
94Complement and coagulation cascades_Homo sapiens_hsa046100.15139412
95Bile secretion_Homo sapiens_hsa049760.14977861
96Insulin signaling pathway_Homo sapiens_hsa049100.14741182
97Ovarian steroidogenesis_Homo sapiens_hsa049130.14730159
98Pancreatic cancer_Homo sapiens_hsa052120.14161950
99Non-small cell lung cancer_Homo sapiens_hsa052230.14033323
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.13954746
101* Metabolic pathways_Homo sapiens_hsa011000.13316212
102Cholinergic synapse_Homo sapiens_hsa047250.13220852
103Glucagon signaling pathway_Homo sapiens_hsa049220.12871647
104Bladder cancer_Homo sapiens_hsa052190.11342159
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.10917833
106Gastric acid secretion_Homo sapiens_hsa049710.10859639
107AMPK signaling pathway_Homo sapiens_hsa041520.10853767
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.08792769
109Fatty acid metabolism_Homo sapiens_hsa012120.07388903
110Inositol phosphate metabolism_Homo sapiens_hsa005620.07314082
111Prion diseases_Homo sapiens_hsa050200.07115893
112Circadian rhythm_Homo sapiens_hsa047100.06984994
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.06930649
114Lysine degradation_Homo sapiens_hsa003100.06362944
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.06093364
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.05244915
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.05239134
118Butanoate metabolism_Homo sapiens_hsa006500.05191068
119Galactose metabolism_Homo sapiens_hsa000520.03649047
120Peroxisome_Homo sapiens_hsa041460.02964882
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.02511985
122Adherens junction_Homo sapiens_hsa045200.01974468
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.01564410
124Phototransduction_Homo sapiens_hsa04744-0.0952047
125Proteasome_Homo sapiens_hsa03050-0.0917261
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514-0.0915659
127TGF-beta signaling pathway_Homo sapiens_hsa04350-0.0737696
128TNF signaling pathway_Homo sapiens_hsa04668-0.0655851
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120-0.0574218
130Pentose phosphate pathway_Homo sapiens_hsa00030-0.0539170
131Collecting duct acid secretion_Homo sapiens_hsa04966-0.0522005
132Tyrosine metabolism_Homo sapiens_hsa00350-0.0274150
133Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860-0.0234487
134Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.0163487
135Ras signaling pathway_Homo sapiens_hsa04014-0.0089146
136Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.0020845

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