PNLIPP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.16573337
2DNA deamination (GO:0045006)4.45818336
3piRNA metabolic process (GO:0034587)4.28538671
4response to pheromone (GO:0019236)4.22095771
5fucose catabolic process (GO:0019317)4.16061480
6L-fucose metabolic process (GO:0042354)4.16061480
7L-fucose catabolic process (GO:0042355)4.16061480
8tryptophan catabolic process (GO:0006569)3.92027768
9indole-containing compound catabolic process (GO:0042436)3.92027768
10indolalkylamine catabolic process (GO:0046218)3.92027768
11kynurenine metabolic process (GO:0070189)3.81743761
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.80087614
13water-soluble vitamin biosynthetic process (GO:0042364)3.78263177
14negative regulation of telomere maintenance (GO:0032205)3.70582653
15regulation of cilium movement (GO:0003352)3.61875977
16DNA methylation involved in gamete generation (GO:0043046)3.60756677
17axoneme assembly (GO:0035082)3.55713911
18platelet dense granule organization (GO:0060155)3.53619802
19indolalkylamine metabolic process (GO:0006586)3.45291334
20epithelial cilium movement (GO:0003351)3.34108733
21pyrimidine nucleobase catabolic process (GO:0006208)3.33625079
22protein localization to cilium (GO:0061512)3.29426787
23mannosylation (GO:0097502)3.22540771
24detection of light stimulus involved in sensory perception (GO:0050962)3.20229825
25detection of light stimulus involved in visual perception (GO:0050908)3.20229825
26respiratory chain complex IV assembly (GO:0008535)3.15575947
27tryptophan metabolic process (GO:0006568)3.09628615
28nucleobase catabolic process (GO:0046113)3.06828165
29protein-cofactor linkage (GO:0018065)3.05531564
30centriole replication (GO:0007099)3.04919359
31amine catabolic process (GO:0009310)2.96358720
32cellular biogenic amine catabolic process (GO:0042402)2.96358720
33protein complex biogenesis (GO:0070271)2.95111885
34synaptic transmission, cholinergic (GO:0007271)2.94417348
35protein polyglutamylation (GO:0018095)2.92605290
36preassembly of GPI anchor in ER membrane (GO:0016254)2.92046690
37tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.91594000
38RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.91594000
39regulation of rhodopsin mediated signaling pathway (GO:0022400)2.90954424
40nonmotile primary cilium assembly (GO:0035058)2.89540450
41regulation of nuclear cell cycle DNA replication (GO:0033262)2.87796868
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.87648853
43mitochondrial respiratory chain complex I assembly (GO:0032981)2.87648853
44NADH dehydrogenase complex assembly (GO:0010257)2.87648853
45cilium morphogenesis (GO:0060271)2.87633549
46regulation of meiosis I (GO:0060631)2.85138332
47rhodopsin mediated signaling pathway (GO:0016056)2.81803956
48ubiquinone biosynthetic process (GO:0006744)2.75609843
49kidney morphogenesis (GO:0060993)2.74925690
50cytochrome complex assembly (GO:0017004)2.70929690
51detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.70814362
52mitochondrial respiratory chain complex assembly (GO:0033108)2.70122115
53inositol phosphate catabolic process (GO:0071545)2.70087320
54regulation of hexokinase activity (GO:1903299)2.69852434
55regulation of glucokinase activity (GO:0033131)2.69852434
56G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.69759431
57intraciliary transport (GO:0042073)2.66936850
58rRNA catabolic process (GO:0016075)2.66020336
59ubiquinone metabolic process (GO:0006743)2.65821132
60regulation of microtubule-based movement (GO:0060632)2.63947792
61S-adenosylmethionine metabolic process (GO:0046500)2.63901351
62GPI anchor metabolic process (GO:0006505)2.62561717
63cellular ketone body metabolic process (GO:0046950)2.60401200
64regulation of telomere maintenance (GO:0032204)2.60123225
65regulation of action potential (GO:0098900)2.58839040
66cilium movement (GO:0003341)2.58520413
67proline transport (GO:0015824)2.58321041
68negative regulation of mast cell activation (GO:0033004)2.55458438
69cornea development in camera-type eye (GO:0061303)2.54791250
70cytidine deamination (GO:0009972)2.54144331
71cytidine metabolic process (GO:0046087)2.54144331
72cytidine catabolic process (GO:0006216)2.54144331
73photoreceptor cell maintenance (GO:0045494)2.53943953
74negative regulation of cytosolic calcium ion concentration (GO:0051481)2.53415640
75aromatic amino acid family catabolic process (GO:0009074)2.52091022
76negative regulation of synaptic transmission, GABAergic (GO:0032229)2.51911113
77regulation of memory T cell differentiation (GO:0043380)2.51561484
78regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.50373329
79cilium organization (GO:0044782)2.49791991
80behavioral response to ethanol (GO:0048149)2.49444006
81positive regulation of oligodendrocyte differentiation (GO:0048714)2.49297336
82positive regulation of prostaglandin secretion (GO:0032308)2.47334840
83indole-containing compound metabolic process (GO:0042430)2.46456042
84gamma-aminobutyric acid transport (GO:0015812)2.46206290
85neuronal action potential (GO:0019228)2.44860210
86base-excision repair, AP site formation (GO:0006285)2.44667157
87oxidative demethylation (GO:0070989)2.43125044
88cilium assembly (GO:0042384)2.43070320
89positive regulation of meiosis (GO:0045836)2.41482272
90nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.40262096
91C4-dicarboxylate transport (GO:0015740)2.39716636
92neuronal action potential propagation (GO:0019227)2.39109222
93positive regulation of fatty acid transport (GO:2000193)2.38847242
94alanine transport (GO:0032328)2.38808662
95DNA demethylation (GO:0080111)2.37994784
96establishment of protein localization to Golgi (GO:0072600)2.37414275
97polyol catabolic process (GO:0046174)2.37402100
98glycerophospholipid catabolic process (GO:0046475)2.37353345
99neural tube formation (GO:0001841)2.36575031
100somatic hypermutation of immunoglobulin genes (GO:0016446)2.35386533

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.03383282
2IGF1R_20145208_ChIP-Seq_DFB_Human3.30929806
3VDR_22108803_ChIP-Seq_LS180_Human2.97318515
4GBX2_23144817_ChIP-Seq_PC3_Human2.71027175
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.64956342
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.40862048
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.40731205
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40332232
9EZH2_22144423_ChIP-Seq_EOC_Human2.27656660
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.25599758
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.21610090
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.18819059
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.07325439
14CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96874588
15SALL1_21062744_ChIP-ChIP_HESCs_Human1.90840643
16ER_23166858_ChIP-Seq_MCF-7_Human1.86913647
17P300_19829295_ChIP-Seq_ESCs_Human1.85557297
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.83500406
19FUS_26573619_Chip-Seq_HEK293_Human1.80237244
20GABP_17652178_ChIP-ChIP_JURKAT_Human1.76584888
21TP53_22573176_ChIP-Seq_HFKS_Human1.74688523
22EWS_26573619_Chip-Seq_HEK293_Human1.71506714
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.63712064
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.62953712
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.60035619
26TAF15_26573619_Chip-Seq_HEK293_Human1.59426481
27IRF1_19129219_ChIP-ChIP_H3396_Human1.53587655
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.52974426
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.52810043
30REST_21632747_ChIP-Seq_MESCs_Mouse1.50189192
31SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46101647
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45976327
33BCAT_22108803_ChIP-Seq_LS180_Human1.43497178
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42591924
35FOXA1_27270436_Chip-Seq_PROSTATE_Human1.41726130
36FOXA1_25329375_ChIP-Seq_VCAP_Human1.41726130
37MYC_18940864_ChIP-ChIP_HL60_Human1.41426246
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40549352
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39639295
40CBP_20019798_ChIP-Seq_JUKART_Human1.39639295
41NFE2_27457419_Chip-Seq_LIVER_Mouse1.38863082
42NANOG_19829295_ChIP-Seq_ESCs_Human1.38815939
43SOX2_19829295_ChIP-Seq_ESCs_Human1.38815939
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38117226
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.37699620
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36642658
47STAT3_23295773_ChIP-Seq_U87_Human1.35373562
48TCF4_23295773_ChIP-Seq_U87_Human1.34986822
49ETV2_25802403_ChIP-Seq_MESCs_Mouse1.34600641
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34420567
51EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34021349
52GATA3_21878914_ChIP-Seq_MCF-7_Human1.32062498
53AR_25329375_ChIP-Seq_VCAP_Human1.30815767
54SMAD4_21799915_ChIP-Seq_A2780_Human1.30471591
55GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29596129
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29292124
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.28902359
58KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27645696
59TCF4_22108803_ChIP-Seq_LS180_Human1.27176399
60NCOR_22424771_ChIP-Seq_293T_Human1.26658549
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26316639
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24324649
63AR_20517297_ChIP-Seq_VCAP_Human1.22735354
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22234794
65HOXB7_26014856_ChIP-Seq_BT474_Human1.22026586
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.21111884
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.20847289
68VDR_23849224_ChIP-Seq_CD4+_Human1.20353532
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.20327077
70FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19367593
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.18559014
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18016765
73REST_18959480_ChIP-ChIP_MESCs_Mouse1.16045546
74RUNX2_22187159_ChIP-Seq_PCA_Human1.14993959
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13801149
76CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.13136614
77SMAD4_21741376_ChIP-Seq_EPCs_Human1.12667669
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11574316
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11574316
80MYC_19829295_ChIP-Seq_ESCs_Human1.11555140
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11291082
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09246700
83FLI1_21867929_ChIP-Seq_TH2_Mouse1.09006032
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08765001
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.08424120
86CRX_20693478_ChIP-Seq_RETINA_Mouse1.08065988
87CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.07599898
88P53_22387025_ChIP-Seq_ESCs_Mouse1.06878795
89ELK1_19687146_ChIP-ChIP_HELA_Human1.05147421
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.04903548
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04343397
92AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04190685
93AR_21572438_ChIP-Seq_LNCaP_Human1.03801668
94SRF_21415370_ChIP-Seq_HL-1_Mouse1.03731214
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03289894
96CDX2_22108803_ChIP-Seq_LS180_Human1.01939008
97NANOG_20526341_ChIP-Seq_ESCs_Human1.01011017
98FOXH1_21741376_ChIP-Seq_EPCs_Human1.00848516
99HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00749507
100TAF2_19829295_ChIP-Seq_ESCs_Human0.98599282

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.27930628
2MP0003787_abnormal_imprinting3.11581758
3MP0002837_dystrophic_cardiac_calcinosis3.05250199
4MP0003195_calcinosis2.63771312
5MP0002102_abnormal_ear_morphology2.49991294
6MP0005551_abnormal_eye_electrophysiolog2.47746857
7MP0001968_abnormal_touch/_nociception2.37306150
8MP0002876_abnormal_thyroid_physiology2.20405630
9MP0002736_abnormal_nociception_after2.12060670
10MP0002638_abnormal_pupillary_reflex2.07838033
11MP0003880_abnormal_central_pattern2.02559272
12MP0006072_abnormal_retinal_apoptosis1.97955158
13MP0009046_muscle_twitch1.96675432
14MP0002163_abnormal_gland_morphology1.95710300
15MP0001986_abnormal_taste_sensitivity1.91855606
16MP0001501_abnormal_sleep_pattern1.89889336
17MP0008872_abnormal_physiological_respon1.89868301
18MP0002653_abnormal_ependyma_morphology1.85110531
19MP0003646_muscle_fatigue1.83408017
20MP0004043_abnormal_pH_regulation1.81243203
21MP0002272_abnormal_nervous_system1.80438623
22MP0003011_delayed_dark_adaptation1.79118296
23MP0009745_abnormal_behavioral_response1.75754126
24MP0000569_abnormal_digit_pigmentation1.75683680
25MP0005253_abnormal_eye_physiology1.74179764
26MP0001984_abnormal_olfaction1.71432267
27MP0003136_yellow_coat_color1.70141496
28MP0006276_abnormal_autonomic_nervous1.69386410
29MP0008875_abnormal_xenobiotic_pharmacok1.67155974
30MP0010386_abnormal_urinary_bladder1.66771646
31MP0005083_abnormal_biliary_tract1.64178620
32MP0004147_increased_porphyrin_level1.62387880
33MP0004142_abnormal_muscle_tone1.60934408
34MP0000427_abnormal_hair_cycle1.54549345
35MP0002254_reproductive_system_inflammat1.54318774
36MP0005646_abnormal_pituitary_gland1.53566918
37MP0004133_heterotaxia1.52282300
38MP0005377_hearing/vestibular/ear_phenot1.49894528
39MP0003878_abnormal_ear_physiology1.49894528
40MP0003121_genomic_imprinting1.44960354
41MP0005645_abnormal_hypothalamus_physiol1.43736794
42MP0005379_endocrine/exocrine_gland_phen1.42447408
43MP0002909_abnormal_adrenal_gland1.41612354
44MP0005075_abnormal_melanosome_morpholog1.40581019
45MP0005084_abnormal_gallbladder_morpholo1.40522131
46MP0001486_abnormal_startle_reflex1.40065477
47MP0006292_abnormal_olfactory_placode1.38670281
48MP0004885_abnormal_endolymph1.38518404
49MP0005365_abnormal_bile_salt1.37115407
50MP0003252_abnormal_bile_duct1.35807986
51MP0002938_white_spotting1.34045945
52MP0001502_abnormal_circadian_rhythm1.31859165
53MP0005085_abnormal_gallbladder_physiolo1.30284847
54MP0002735_abnormal_chemical_nociception1.28260019
55MP0000372_irregular_coat_pigmentation1.26218932
56MP0001970_abnormal_pain_threshold1.23700391
57MP0008058_abnormal_DNA_repair1.23158784
58MP0002572_abnormal_emotion/affect_behav1.22688227
59MP0003122_maternal_imprinting1.22381035
60MP0005423_abnormal_somatic_nervous1.21679315
61MP0001485_abnormal_pinna_reflex1.18001518
62MP0002064_seizures1.16533680
63MP0000631_abnormal_neuroendocrine_gland1.14291675
64MP0002557_abnormal_social/conspecific_i1.14111441
65MP0002733_abnormal_thermal_nociception1.13774087
66MP0001529_abnormal_vocalization1.09555216
67MP0003635_abnormal_synaptic_transmissio1.07310779
68MP0005174_abnormal_tail_pigmentation1.05270261
69MP0001905_abnormal_dopamine_level1.04554670
70MP0004145_abnormal_muscle_electrophysio1.02118605
71MP0002063_abnormal_learning/memory/cond1.00111932
72MP0004924_abnormal_behavior0.98170907
73MP0005386_behavior/neurological_phenoty0.98170907
74MP0002734_abnormal_mechanical_nocicepti0.96540686
75MP0003137_abnormal_impulse_conducting0.94121912
76MP0002067_abnormal_sensory_capabilities0.94102591
77MP0002928_abnormal_bile_duct0.93449491
78MP0002234_abnormal_pharynx_morphology0.93072197
79MP0005195_abnormal_posterior_eye0.93030286
80MP0001764_abnormal_homeostasis0.92488844
81MP0002138_abnormal_hepatobiliary_system0.91812631
82MP0000230_abnormal_systemic_arterial0.91377773
83MP0002751_abnormal_autonomic_nervous0.91157854
84MP0002095_abnormal_skin_pigmentation0.90378300
85MP0005671_abnormal_response_to0.89873685
86MP0000015_abnormal_ear_pigmentation0.87475021
87MP0002752_abnormal_somatic_nervous0.86279205
88MP0002229_neurodegeneration0.84847192
89MP0002160_abnormal_reproductive_system0.84530325
90MP0002184_abnormal_innervation0.82755322
91MP0005332_abnormal_amino_acid0.82230075
92MP0003283_abnormal_digestive_organ0.81664806
93MP0008775_abnormal_heart_ventricle0.81498527
94MP0003718_maternal_effect0.81375372
95MP0005389_reproductive_system_phenotype0.80571925
96MP0005410_abnormal_fertilization0.80315821
97MP0001963_abnormal_hearing_physiology0.79330919
98MP0000778_abnormal_nervous_system0.77075409
99MP0008789_abnormal_olfactory_epithelium0.76239807
100MP0002277_abnormal_respiratory_mucosa0.73594712

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.46491699
2Abnormality of midbrain morphology (HP:0002418)4.08183684
3Molar tooth sign on MRI (HP:0002419)4.08183684
4Congenital stationary night blindness (HP:0007642)3.95480878
5Pancreatic fibrosis (HP:0100732)3.87311384
6Abnormality of the renal cortex (HP:0011035)3.82112402
7Nephronophthisis (HP:0000090)3.81493433
8Type II lissencephaly (HP:0007260)3.77375816
9True hermaphroditism (HP:0010459)3.59873962
10Abnormality of the renal medulla (HP:0100957)3.37077303
11Medial flaring of the eyebrow (HP:0010747)3.33370413
12Tubular atrophy (HP:0000092)3.03106770
13Abolished electroretinogram (ERG) (HP:0000550)3.00413303
14Renal cortical cysts (HP:0000803)2.97814694
15Pendular nystagmus (HP:0012043)2.93658421
16Abnormal rod and cone electroretinograms (HP:0008323)2.87374842
17Cystic liver disease (HP:0006706)2.83678427
18Gait imbalance (HP:0002141)2.79520449
19Abnormal drinking behavior (HP:0030082)2.74151421
20Polydipsia (HP:0001959)2.74151421
21Congenital primary aphakia (HP:0007707)2.71153323
22Cerebellar dysplasia (HP:0007033)2.67101031
23Lissencephaly (HP:0001339)2.65922270
24Abnormal biliary tract physiology (HP:0012439)2.60298286
25Bile duct proliferation (HP:0001408)2.60298286
26Attenuation of retinal blood vessels (HP:0007843)2.56681711
27Nephrogenic diabetes insipidus (HP:0009806)2.49075584
28Chronic hepatic failure (HP:0100626)2.46335225
29Focal motor seizures (HP:0011153)2.39824864
30Acute necrotizing encephalopathy (HP:0006965)2.39677116
31Decreased electroretinogram (ERG) amplitude (HP:0000654)2.39560000
32Inability to walk (HP:0002540)2.31199623
33Increased CSF lactate (HP:0002490)2.29832398
34Hyperventilation (HP:0002883)2.27594031
35Abnormality of the labia minora (HP:0012880)2.27107128
36Mitochondrial inheritance (HP:0001427)2.26846799
37Pachygyria (HP:0001302)2.22908518
38Genital tract atresia (HP:0001827)2.21534318
39Polyuria (HP:0000103)2.19701909
40Vaginal atresia (HP:0000148)2.18421852
41Acute encephalopathy (HP:0006846)2.16600164
42Sclerocornea (HP:0000647)2.11347231
43Progressive inability to walk (HP:0002505)2.11264435
44Methylmalonic acidemia (HP:0002912)2.11105366
45Abnormality of macular pigmentation (HP:0008002)2.10077431
46Broad-based gait (HP:0002136)2.09694006
47Increased corneal curvature (HP:0100692)2.09368971
48Keratoconus (HP:0000563)2.09368971
49Anencephaly (HP:0002323)2.08473898
50Progressive macrocephaly (HP:0004481)2.07828087
51Colon cancer (HP:0003003)2.04748804
52Focal seizures (HP:0007359)2.03191479
53Optic disc pallor (HP:0000543)2.00622944
54Postaxial foot polydactyly (HP:0001830)2.00299710
55Congenital hepatic fibrosis (HP:0002612)1.99423817
56Severe muscular hypotonia (HP:0006829)1.97170506
57Aplasia/Hypoplasia of the tibia (HP:0005772)1.94570214
58Absent rod-and cone-mediated responses on ERG (HP:0007688)1.94187661
59Aplasia/hypoplasia of the uterus (HP:0008684)1.94182245
60Hypothermia (HP:0002045)1.94043266
61Aplasia/Hypoplasia of the tongue (HP:0010295)1.93398986
62Aplasia/Hypoplasia of the spleen (HP:0010451)1.92802073
63Hyperglycinuria (HP:0003108)1.92674624
64Abnormal mitochondria in muscle tissue (HP:0008316)1.91597810
65Decreased central vision (HP:0007663)1.90475352
66Aplasia/Hypoplasia of the fovea (HP:0008060)1.88857056
67Hypoplasia of the fovea (HP:0007750)1.88857056
68Retinitis pigmentosa (HP:0000510)1.88288569
69Hyperglycinemia (HP:0002154)1.88054337
70Postaxial hand polydactyly (HP:0001162)1.87863155
71Poor coordination (HP:0002370)1.87428530
72Hepatocellular necrosis (HP:0001404)1.86572649
73Hypoalbuminemia (HP:0003073)1.86342113
74Abnormal albumin level (HP:0012116)1.86342113
75Stomach cancer (HP:0012126)1.85914527
76Parakeratosis (HP:0001036)1.85294631
77Disproportionate short-trunk short stature (HP:0003521)1.84739505
78Ketosis (HP:0001946)1.84646367
79Hypomagnesemia (HP:0002917)1.81265746
80Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79900241
81Abnormality of alanine metabolism (HP:0010916)1.79096337
82Hyperalaninemia (HP:0003348)1.79096337
83Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79096337
84Optic nerve hypoplasia (HP:0000609)1.77478745
85Neoplasm of the adrenal cortex (HP:0100641)1.77447869
86Abnormality of the prostate (HP:0008775)1.77078217
87Hepatic necrosis (HP:0002605)1.76950826
88Tubulointerstitial abnormality (HP:0001969)1.76557882
89Methylmalonic aciduria (HP:0012120)1.76119459
90Amelogenesis imperfecta (HP:0000705)1.75126380
91Hypoproteinemia (HP:0003075)1.74711215
92Decreased circulating renin level (HP:0003351)1.74611613
93Abnormality of serine family amino acid metabolism (HP:0010894)1.74468491
94Abnormality of glycine metabolism (HP:0010895)1.74468491
95Polyphagia (HP:0002591)1.72785211
963-Methylglutaconic aciduria (HP:0003535)1.72644544
97Absent speech (HP:0001344)1.72548484
98Dandy-Walker malformation (HP:0001305)1.72338688
99Abnormal urine output (HP:0012590)1.72168042
100Male pseudohermaphroditism (HP:0000037)1.72113472

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.72164937
2MAP4K23.73252530
3WNK43.16840873
4ADRBK22.81562285
5ZAK2.79730866
6WNK32.76238361
7BMPR1B2.57978079
8GRK12.52404512
9NUAK12.28721908
10TXK1.98527395
11PINK11.96613388
12MAP3K41.92386871
13CAMKK21.88669233
14CASK1.86350561
15OXSR11.79957639
16ACVR1B1.76553914
17NEK21.68511699
18TAOK31.62771765
19STK38L1.59726052
20TRIM281.56789841
21MAPK131.55874757
22STK391.50937956
23TNIK1.42875894
24INSRR1.41514708
25TLK11.35715812
26BCKDK1.35235356
27DAPK21.34939377
28NME11.34400278
29DYRK21.31537903
30MARK11.28834381
31BCR1.21751669
32CSNK1G31.19422055
33CSNK1G11.15940660
34CSNK1G21.13485151
35MAP2K71.13218759
36PHKG11.12532343
37PHKG21.12532343
38PAK31.07608048
39CSNK1A1L1.03372036
40MKNK21.01267808
41CDK190.98885187
42PRKCE0.90423907
43ADRBK10.89268728
44TIE10.79390378
45PRKCG0.77556815
46CAMK10.76848405
47MAP2K20.74796070
48GRK70.74035194
49CCNB10.73555211
50STK160.71730950
51PRKCI0.70461747
52MST40.67801136
53EPHA40.67586373
54PTK2B0.66502205
55MAPKAPK30.63581839
56PRKCQ0.63388910
57LATS10.63046710
58RPS6KA40.62869549
59VRK10.62417070
60EIF2AK30.62099119
61MAP3K120.61256040
62VRK20.60728262
63PLK20.60537683
64NTRK30.59322310
65EPHA30.59016400
66IKBKB0.57676905
67DAPK10.56840319
68ERBB30.55612288
69TNK20.55005375
70CSNK1A10.54211962
71TGFBR10.54168885
72CAMK1D0.54145749
73RPS6KA50.53837517
74PRKACA0.48577045
75PRKAA20.48299393
76PIK3CA0.48264529
77STK30.46438216
78FGFR20.45437519
79CAMK2A0.44813607
80NEK10.42422106
81IRAK10.42320832
82MAP2K60.41471316
83MKNK10.41377927
84CAMK1G0.41301124
85NTRK20.41161570
86MINK10.40761119
87CHUK0.39297281
88PLK30.39189941
89PRKAA10.38598280
90MAPKAPK50.37549445
91STK110.37164264
92TEC0.35366786
93ITK0.35330152
94TAF10.34540800
95STK380.34395532
96PRKCA0.34337417
97CSNK1D0.33224318
98NLK0.32831374
99FES0.31312432
100MAP3K70.29851568

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.07351277
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.60063515
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.48478899
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.32422658
5Linoleic acid metabolism_Homo sapiens_hsa005912.30905518
6Oxidative phosphorylation_Homo sapiens_hsa001902.28233559
7Nicotine addiction_Homo sapiens_hsa050332.21151746
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.21108387
9Protein export_Homo sapiens_hsa030602.14057226
10Butanoate metabolism_Homo sapiens_hsa006502.13749707
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.13271499
12Maturity onset diabetes of the young_Homo sapiens_hsa049501.96776812
13Tryptophan metabolism_Homo sapiens_hsa003801.90775791
14Nitrogen metabolism_Homo sapiens_hsa009101.88747567
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.85693732
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.82626047
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.81827942
18Basal transcription factors_Homo sapiens_hsa030221.76331570
19Ether lipid metabolism_Homo sapiens_hsa005651.69455999
20RNA polymerase_Homo sapiens_hsa030201.69119651
21Selenocompound metabolism_Homo sapiens_hsa004501.67324372
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.65636837
23Parkinsons disease_Homo sapiens_hsa050121.64723913
24Propanoate metabolism_Homo sapiens_hsa006401.63329609
25Caffeine metabolism_Homo sapiens_hsa002321.61543875
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41257130
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.32317030
28Peroxisome_Homo sapiens_hsa041461.28109322
29Homologous recombination_Homo sapiens_hsa034401.24070146
30Morphine addiction_Homo sapiens_hsa050321.21649965
31Fanconi anemia pathway_Homo sapiens_hsa034601.19387200
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18295596
33RNA degradation_Homo sapiens_hsa030181.17264239
34Insulin secretion_Homo sapiens_hsa049111.16885939
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.12838991
36Taste transduction_Homo sapiens_hsa047421.11225262
37Chemical carcinogenesis_Homo sapiens_hsa052041.08017247
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05291859
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.05186588
40Cardiac muscle contraction_Homo sapiens_hsa042601.04959350
41Steroid biosynthesis_Homo sapiens_hsa001001.04837917
42Type I diabetes mellitus_Homo sapiens_hsa049401.02647360
43Collecting duct acid secretion_Homo sapiens_hsa049661.02476772
44beta-Alanine metabolism_Homo sapiens_hsa004101.01424075
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.01282995
46One carbon pool by folate_Homo sapiens_hsa006701.00136290
47Non-homologous end-joining_Homo sapiens_hsa034500.98212156
48Primary immunodeficiency_Homo sapiens_hsa053400.97731531
49Olfactory transduction_Homo sapiens_hsa047400.97726258
50Regulation of autophagy_Homo sapiens_hsa041400.96853043
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96805943
52Alzheimers disease_Homo sapiens_hsa050100.96723994
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96249005
54GABAergic synapse_Homo sapiens_hsa047270.95316448
55Arachidonic acid metabolism_Homo sapiens_hsa005900.95159082
56Huntingtons disease_Homo sapiens_hsa050160.94997048
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94780764
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94470154
59Retinol metabolism_Homo sapiens_hsa008300.94326594
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92828510
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86737495
62Glutamatergic synapse_Homo sapiens_hsa047240.83703818
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82687040
64Asthma_Homo sapiens_hsa053100.81545432
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79240045
66Proteasome_Homo sapiens_hsa030500.78713282
67Serotonergic synapse_Homo sapiens_hsa047260.78538715
68Fat digestion and absorption_Homo sapiens_hsa049750.74316593
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73305910
70Circadian entrainment_Homo sapiens_hsa047130.72088535
71Purine metabolism_Homo sapiens_hsa002300.70781408
72Metabolic pathways_Homo sapiens_hsa011000.69827394
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.69797232
74Ovarian steroidogenesis_Homo sapiens_hsa049130.69475068
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67969019
76ABC transporters_Homo sapiens_hsa020100.67645459
77Sulfur metabolism_Homo sapiens_hsa009200.67184619
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.66158256
79Rheumatoid arthritis_Homo sapiens_hsa053230.64449503
80Circadian rhythm_Homo sapiens_hsa047100.62943792
81Histidine metabolism_Homo sapiens_hsa003400.61972593
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.61535111
83Salivary secretion_Homo sapiens_hsa049700.60966592
84Glycerolipid metabolism_Homo sapiens_hsa005610.60208032
85Synaptic vesicle cycle_Homo sapiens_hsa047210.57795465
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56186132
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55137238
88Autoimmune thyroid disease_Homo sapiens_hsa053200.51601817
89Allograft rejection_Homo sapiens_hsa053300.50702244
90Graft-versus-host disease_Homo sapiens_hsa053320.50664313
91Sphingolipid metabolism_Homo sapiens_hsa006000.49975107
92Fatty acid degradation_Homo sapiens_hsa000710.48510511
93Fatty acid elongation_Homo sapiens_hsa000620.44100603
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42828478
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42564097
96Mineral absorption_Homo sapiens_hsa049780.41665000
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41586458
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41403020
99Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.40892101
100Dopaminergic synapse_Homo sapiens_hsa047280.39734356

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