PNLIPRP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1transcytosis (GO:0045056)9.81475221
2negative regulation of epidermal cell differentiation (GO:0045605)9.50518444
3regulation of phospholipase A2 activity (GO:0032429)9.05354585
4intestinal cholesterol absorption (GO:0030299)8.09398357
5digestion (GO:0007586)7.68327314
6COPI coating of Golgi vesicle (GO:0048205)7.41430804
7Golgi transport vesicle coating (GO:0048200)7.41430804
8cobalamin metabolic process (GO:0009235)7.34412479
9phosphatidylinositol acyl-chain remodeling (GO:0036149)7.27936335
10maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.13328699
11negative regulation of epidermis development (GO:0045683)7.08209897
12protein retention in ER lumen (GO:0006621)6.97033424
13phosphatidylserine acyl-chain remodeling (GO:0036150)6.90864222
14arachidonic acid secretion (GO:0050482)6.58915303
15icosanoid secretion (GO:0032309)6.58915303
16neutrophil mediated immunity (GO:0002446)6.44493491
17phosphatidylglycerol acyl-chain remodeling (GO:0036148)6.43849337
18intestinal epithelial cell development (GO:0060576)6.32611736
19membrane lipid catabolic process (GO:0046466)5.78395157
20endocrine pancreas development (GO:0031018)5.70349534
21glucocorticoid metabolic process (GO:0008211)5.64765223
22cellular protein catabolic process (GO:0044257)5.48438000
23glycolipid catabolic process (GO:0019377)5.41291961
24fatty acid derivative transport (GO:1901571)5.26128373
25icosanoid transport (GO:0071715)5.26128373
26phosphatidylethanolamine acyl-chain remodeling (GO:0036152)5.23855779
27activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.12819626
28polarized epithelial cell differentiation (GO:0030859)5.10259045
29positive regulation of nuclease activity (GO:0032075)5.02162507
30regulation of keratinocyte proliferation (GO:0010837)4.88112981
31insulin-like growth factor receptor signaling pathway (GO:0048009)4.81931217
32tetrapyrrole metabolic process (GO:0033013)4.74387985
33cell proliferation involved in metanephros development (GO:0072203)4.68957933
34myeloid leukocyte mediated immunity (GO:0002444)4.67344755
35ceramide catabolic process (GO:0046514)4.64686593
36leukotriene biosynthetic process (GO:0019370)4.61673925
37regulation of nuclease activity (GO:0032069)4.53622058
38regulation of acrosome reaction (GO:0060046)4.51313886
39phosphatidylcholine acyl-chain remodeling (GO:0036151)4.44459756
40regulation of keratinocyte differentiation (GO:0045616)4.42490008
41phosphatidylserine metabolic process (GO:0006658)4.31388324
42glycoprotein catabolic process (GO:0006516)4.30949187
43innate immune response in mucosa (GO:0002227)4.26794318
44endoplasmic reticulum unfolded protein response (GO:0030968)4.19285326
45cholesterol catabolic process (GO:0006707)4.12577314
46sterol catabolic process (GO:0016127)4.12577314
47establishment of apical/basal cell polarity (GO:0035089)4.10896879
48regulation of pigment cell differentiation (GO:0050932)4.07040827
49retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.98477159
50cellular response to unfolded protein (GO:0034620)3.97599373
51embryonic foregut morphogenesis (GO:0048617)3.96005443
52sterol transport (GO:0015918)3.94578971
53cholesterol transport (GO:0030301)3.94578971
54negative regulation of mRNA metabolic process (GO:1903312)3.89997506
55daunorubicin metabolic process (GO:0044597)3.89602168
56polyketide metabolic process (GO:0030638)3.89602168
57doxorubicin metabolic process (GO:0044598)3.89602168
58mucosal immune response (GO:0002385)3.88051712
59ER-nucleus signaling pathway (GO:0006984)3.87389692
60intestinal absorption (GO:0050892)3.86116592
61water-soluble vitamin metabolic process (GO:0006767)3.84062046
62peptidyl-proline hydroxylation (GO:0019511)3.80863646
63digestive system process (GO:0022600)3.78012175
64protein hydroxylation (GO:0018126)3.77044317
65phospholipid catabolic process (GO:0009395)3.74907718
66positive regulation of glycogen biosynthetic process (GO:0045725)3.74658164
67axon extension involved in axon guidance (GO:0048846)3.68663447
68neuron projection extension involved in neuron projection guidance (GO:1902284)3.68663447
69cellular response to topologically incorrect protein (GO:0035967)3.66267824
70aminoglycoside antibiotic metabolic process (GO:0030647)3.62692356
71response to endoplasmic reticulum stress (GO:0034976)3.62313956
72water-soluble vitamin biosynthetic process (GO:0042364)3.60778249
73positive regulation of developmental pigmentation (GO:0048087)3.57702234
74COPII vesicle coating (GO:0048208)3.57672663
75glucocorticoid receptor signaling pathway (GO:0042921)3.56697005
76phosphatidic acid metabolic process (GO:0046473)3.55309221
77phosphatidic acid biosynthetic process (GO:0006654)3.55309221
78alditol phosphate metabolic process (GO:0052646)3.52628655
79mesenchymal cell proliferation (GO:0010463)3.51659455
80establishment or maintenance of monopolar cell polarity (GO:0061339)3.50716454
81establishment of monopolar cell polarity (GO:0061162)3.50716454
82body morphogenesis (GO:0010171)3.46496772
83organ or tissue specific immune response (GO:0002251)3.45385299
84phosphatidylglycerol metabolic process (GO:0046471)3.36824024
85maternal placenta development (GO:0001893)3.33511502
86embryonic retina morphogenesis in camera-type eye (GO:0060059)3.30056094
87pancreas development (GO:0031016)3.29170086
88negative regulation of glycogen biosynthetic process (GO:0045719)3.27008686
89vesicle coating (GO:0006901)3.22593329
90antibacterial humoral response (GO:0019731)3.16234126
91regulation of cardioblast differentiation (GO:0051890)3.15864705
92mitochondrial calcium ion transport (GO:0006851)3.15850264
93proline biosynthetic process (GO:0006561)3.15141306
94response to unfolded protein (GO:0006986)3.13236252
95membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.12229592
96nephron tubule morphogenesis (GO:0072078)3.12117408
97nephron epithelium morphogenesis (GO:0072088)3.12117408
98protein targeting to ER (GO:0045047)3.12072419
99SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.11746908
100negative regulation of fatty acid transport (GO:2000192)3.10626708
101L-fucose catabolic process (GO:0042355)3.09225734
102fucose catabolic process (GO:0019317)3.09225734
103L-fucose metabolic process (GO:0042354)3.09225734
104paraxial mesoderm development (GO:0048339)3.09094171
105columnar/cuboidal epithelial cell development (GO:0002066)3.08859310
106cotranslational protein targeting to membrane (GO:0006613)3.06397155
107positive regulation of glycogen metabolic process (GO:0070875)3.05011754
108planar cell polarity pathway involved in neural tube closure (GO:0090179)3.02022999
109S-adenosylmethionine metabolic process (GO:0046500)3.01110958
110establishment of protein localization to endoplasmic reticulum (GO:0072599)2.99824054
111negative regulation of Notch signaling pathway (GO:0045746)2.98298825
112peptidyl-asparagine modification (GO:0018196)2.97992311
113vitamin metabolic process (GO:0006766)2.95378580
114response to topologically incorrect protein (GO:0035966)2.94241651
115Golgi organization (GO:0007030)2.93716409
116sphingolipid catabolic process (GO:0030149)2.93658088
117protein N-linked glycosylation via asparagine (GO:0018279)2.93552953
118positive regulation of Rap GTPase activity (GO:0032854)2.93134849
119phototransduction, visible light (GO:0007603)2.93071598
120cell proliferation involved in kidney development (GO:0072111)2.92529118
121negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.92371674
122myelin maintenance (GO:0043217)2.90117030
123dorsal/ventral axis specification (GO:0009950)2.89656707
124cytoskeletal anchoring at plasma membrane (GO:0007016)2.89263745
125signal peptide processing (GO:0006465)2.87605404
126renal tubule morphogenesis (GO:0061333)2.87524044
127defense response to Gram-positive bacterium (GO:0050830)2.87183700
128L-serine metabolic process (GO:0006563)2.85158040
129regulation of glucan biosynthetic process (GO:0010962)2.84792625
130regulation of glycogen biosynthetic process (GO:0005979)2.84792625
131gastrulation with mouth forming second (GO:0001702)2.83823068
132acute-phase response (GO:0006953)2.83287469
1334-hydroxyproline metabolic process (GO:0019471)2.82965162
134protein localization to endoplasmic reticulum (GO:0070972)2.82653985
135leukotriene metabolic process (GO:0006691)2.81184877
136regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.80722513
137ectodermal placode formation (GO:0060788)2.80485219
138negative regulation of mRNA processing (GO:0050686)2.80317769
139genetic imprinting (GO:0071514)2.78134747
140antimicrobial humoral response (GO:0019730)2.78060480
141serine family amino acid biosynthetic process (GO:0009070)2.77590475
142detection of visible light (GO:0009584)2.77507740
143positive regulation of hormone biosynthetic process (GO:0046886)2.77476987
144corticosteroid receptor signaling pathway (GO:0031958)2.76894673
145negative regulation of glycogen metabolic process (GO:0070874)2.76808053
146lung-associated mesenchyme development (GO:0060484)2.76208555
147aspartate family amino acid catabolic process (GO:0009068)2.75615402
148establishment of epithelial cell polarity (GO:0090162)2.74386781
149hippo signaling (GO:0035329)2.74211275
150extracellular matrix disassembly (GO:0022617)2.74009317
151membrane repolarization during action potential (GO:0086011)2.72264378
152epithelial cell differentiation involved in prostate gland development (GO:0060742)2.71359678
153negative regulation of epithelial cell differentiation (GO:0030857)2.70070791
154steroid catabolic process (GO:0006706)2.68157580
155behavioral response to nicotine (GO:0035095)2.68021095
156atrioventricular valve morphogenesis (GO:0003181)2.67844787
157protein N-linked glycosylation (GO:0006487)2.66019033
158preassembly of GPI anchor in ER membrane (GO:0016254)2.62546788
159mannosylation (GO:0097502)2.55089085
160retinoid metabolic process (GO:0001523)2.53882132
161phototransduction (GO:0007602)2.52631099
162detection of light stimulus (GO:0009583)2.47015039
163diterpenoid metabolic process (GO:0016101)2.46344060
164regulation of calcium ion-dependent exocytosis (GO:0017158)2.43800190
165regulation of epidermal cell differentiation (GO:0045604)2.42156692
166uronic acid metabolic process (GO:0006063)2.41813078
167glucuronate metabolic process (GO:0019585)2.41813078
168alcohol catabolic process (GO:0046164)2.39471199
169cellular response to zinc ion (GO:0071294)2.35573913
170glutathione derivative biosynthetic process (GO:1901687)2.35166137
171glutathione derivative metabolic process (GO:1901685)2.35166137
172regulation of calcium ion import (GO:0090279)2.34445099
173cellular glucuronidation (GO:0052695)2.34212185
174fatty acid derivative biosynthetic process (GO:1901570)2.31926907
175icosanoid biosynthetic process (GO:0046456)2.31926907
176cellular ketone body metabolic process (GO:0046950)2.31766304
177regulation of triglyceride catabolic process (GO:0010896)2.31378630
178terpenoid metabolic process (GO:0006721)2.26633584
179response to pheromone (GO:0019236)2.23262912
180lipid catabolic process (GO:0016042)2.22739656
181acid secretion (GO:0046717)2.21138038
182quinone metabolic process (GO:1901661)2.19281325
183L-alpha-amino acid transmembrane transport (GO:1902475)2.18521324
184sulfation (GO:0051923)2.17476539
185detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.16313581
186exocrine pancreas development (GO:0031017)13.4148111

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.71131668
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.62790297
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.59853272
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.44090702
5CLOCK_20551151_ChIP-Seq_293T_Human2.98559783
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.94552281
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.82970846
8VDR_22108803_ChIP-Seq_LS180_Human2.75286122
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.72828770
10ZNF274_21170338_ChIP-Seq_K562_Hela2.58245452
11SOX2_27498859_Chip-Seq_STOMACH_Mouse2.49448017
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.45031372
13GATA1_22025678_ChIP-Seq_K562_Human2.41425892
14PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.38804616
15AR_21909140_ChIP-Seq_LNCAP_Human2.37363044
16ZFP281_18757296_ChIP-ChIP_E14_Mouse2.33556189
17ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.31829579
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.28849387
19GBX2_23144817_ChIP-Seq_PC3_Human2.25436208
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.20049595
21MYC_22102868_ChIP-Seq_BL_Human2.18761898
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.09463986
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02451173
24LXR_22158963_ChIP-Seq_LIVER_Mouse1.99228601
25PPARA_22158963_ChIP-Seq_LIVER_Mouse1.98848551
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.98653889
27P300_19829295_ChIP-Seq_ESCs_Human1.94828463
28EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.92997141
29PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.91641349
30DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.90407194
31TAF15_26573619_Chip-Seq_HEK293_Human1.88461559
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.85137669
33* GATA6_25053715_ChIP-Seq_YYC3_Human1.80556164
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.78075756
35HTT_18923047_ChIP-ChIP_STHdh_Human1.77603298
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77095983
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.75373789
38CHD1_26751641_Chip-Seq_LNCaP_Human1.74916452
39ZNF263_19887448_ChIP-Seq_K562_Human1.74217945
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72348131
41LXR_22292898_ChIP-Seq_THP-1_Human1.72189629
42* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70768436
43NFIB_24661679_ChIP-Seq_LUNG_Mouse1.70431154
44RXR_22158963_ChIP-Seq_LIVER_Mouse1.69955901
45TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.67929822
46IGF1R_20145208_ChIP-Seq_DFB_Human1.67261462
47KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.66851103
48KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.66851103
49KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.66851103
50RACK7_27058665_Chip-Seq_MCF-7_Human1.64627911
51MYC_18555785_ChIP-Seq_MESCs_Mouse1.63781105
52ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.63109564
53GATA4_25053715_ChIP-Seq_YYC3_Human1.62853090
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.61238541
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.60834524
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.60507184
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.59485248
58RUNX1_27514584_Chip-Seq_MCF-7_Human1.57733374
59ESR1_21235772_ChIP-Seq_MCF-7_Human1.56564855
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.56012031
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.55920473
62ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.55186950
63ZFP281_27345836_Chip-Seq_ESCs_Mouse1.53798843
64CREB1_26743006_Chip-Seq_LNCaP_Human1.53264624
65ETV1_20927104_ChIP-Seq_GIST48_Human1.53018270
66NANOG_19829295_ChIP-Seq_ESCs_Human1.52465448
67SOX2_19829295_ChIP-Seq_ESCs_Human1.52465448
68SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.51669623
69IRF8_22096565_ChIP-ChIP_GC-B_Human1.50949824
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50496183
71CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.49858074
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49708342
73PHF8_20622853_ChIP-Seq_HELA_Human1.48560987
74FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.48270908
75FUS_26573619_Chip-Seq_HEK293_Human1.48239014
76CBP_20019798_ChIP-Seq_JUKART_Human1.47463921
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47463921
78OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.47346026
79PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.46879937
80GABP_17652178_ChIP-ChIP_JURKAT_Human1.46576303
81AR_20517297_ChIP-Seq_VCAP_Human1.45815507
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.44911165
83EGR1_19032775_ChIP-ChIP_M12_Human1.44653661
84FOXA1_21572438_ChIP-Seq_LNCaP_Human1.44344267
85RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.44281591
86E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.43843039
87CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43772061
88PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.43520934
89FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.43366811
90KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.42292115
91PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.42064482
92FOXA1_27270436_Chip-Seq_PROSTATE_Human1.41922615
93FOXA1_25329375_ChIP-Seq_VCAP_Human1.41922615
94KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41448383
95ER_23166858_ChIP-Seq_MCF-7_Human1.40950076
96RBPJ_21746931_ChIP-Seq_IB4_Human1.40799905
97NANOG_21062744_ChIP-ChIP_HESCs_Human1.38802819
98ETV2_25802403_ChIP-Seq_MESCs_Mouse1.37840012
99GATA6_21074721_ChIP-Seq_CACO-2_Human1.36454627
100P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35710891
101FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.35443380
102HNFA_21074721_ChIP-Seq_CACO-2_Human1.34941247
103NFYA_21822215_ChIP-Seq_K562_Human1.34476330
104EGR1_23403033_ChIP-Seq_LIVER_Mouse1.33475017
105TP53_22127205_ChIP-Seq_IMR90_Human1.33089792
106TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32481703
107EWS_26573619_Chip-Seq_HEK293_Human1.32297437
108CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.31229707
109KLF5_20875108_ChIP-Seq_MESCs_Mouse1.31146807
110TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29858015
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29793257
112CBX2_22325352_ChIP-Seq_293T-Rex_Human1.29712963
113SMAD4_21741376_ChIP-Seq_EPCs_Human1.27501853
114GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.27374631
115KDM2B_26808549_Chip-Seq_K562_Human1.27238397
116E2F7_22180533_ChIP-Seq_HELA_Human1.26986469
117FOXA2_19822575_ChIP-Seq_HepG2_Human1.25504825
118NFYB_21822215_ChIP-Seq_K562_Human1.25207236
119PKCTHETA_26484144_Chip-Seq_BREAST_Human1.25159959
120TP53_22573176_ChIP-Seq_HFKS_Human1.24679992
121PIAS1_25552417_ChIP-Seq_VCAP_Human1.23347889
122KDM2B_26808549_Chip-Seq_DND41_Human1.22223020
123KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.21933097
124NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21779091
125CDX2_22108803_ChIP-Seq_LS180_Human1.21629001
126FOXH1_21741376_ChIP-Seq_EPCs_Human1.21414040
127GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21174614
128NCOR1_26117541_ChIP-Seq_K562_Human1.19612059
129SMAD4_21799915_ChIP-Seq_A2780_Human1.19273960
130CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18464525
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18244813
132TCF7_22412390_ChIP-Seq_EML_Mouse1.18029435
133TBX20_22080862_ChIP-Seq_HEART_Mouse1.17078114
134TBX20_22328084_ChIP-Seq_HEART_Mouse1.17078114
135TCF4_18268006_ChIP-ChIP_LS174T_Human1.16069172
136TAF2_19829295_ChIP-Seq_ESCs_Human1.16059883
137EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16013757
138AUTS2_25519132_ChIP-Seq_293T-REX_Human1.15641181
139NCOR_22424771_ChIP-Seq_293T_Human1.15363158
140ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15127261
141SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14963717
142FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.14691649
143REST_21632747_ChIP-Seq_MESCs_Mouse1.14187381
144NOTCH1_21737748_ChIP-Seq_TLL_Human1.13927490
145KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13721621
146* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13508996
147BCAT_22108803_ChIP-Seq_LS180_Human1.11605255
148AR_25329375_ChIP-Seq_VCAP_Human1.11236240
149ISL1_27105846_Chip-Seq_CPCs_Mouse1.11056655
150ERA_21632823_ChIP-Seq_H3396_Human1.10220774
151TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09510661
152MYC_18940864_ChIP-ChIP_HL60_Human1.09161867
153MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08682764
154MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08598932
155ATF3_27146783_Chip-Seq_COLON_Human1.08089464
156* RUNX2_22187159_ChIP-Seq_PCA_Human1.07674569
157HOXB7_26014856_ChIP-Seq_BT474_Human1.07380088
158NFE2_27457419_Chip-Seq_LIVER_Mouse1.07173033
159EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07121660
160PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06588671
161IRF1_19129219_ChIP-ChIP_H3396_Human1.06404933
162MYC_19829295_ChIP-Seq_ESCs_Human1.06384348
163GATA1_19941826_ChIP-Seq_K562_Human1.06109485
164NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05923838
165EZH2_22144423_ChIP-Seq_EOC_Human1.04381733
166TCF4_23295773_ChIP-Seq_U87_Human1.04288957
167* STAT3_23295773_ChIP-Seq_U87_Human1.03983279
168TBL1_22424771_ChIP-Seq_293T_Human1.03495387
169ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02121067
170PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01865304
171PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01818728
172ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01259831
173SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01151775
174CEBPB_22108803_ChIP-Seq_LS180_Human1.00780236
175SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00683704
176EZH2_27294783_Chip-Seq_NPCs_Mouse1.00239421
177GATA3_21878914_ChIP-Seq_MCF-7_Human1.00103766
178ESR1_20079471_ChIP-ChIP_T-47D_Human1.00064439
179AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99864304
180EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99754263
181WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99609146
182NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98585488
183FOXO3_23340844_ChIP-Seq_DLD1_Human0.96507570
184E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94796485
185P68_20966046_ChIP-Seq_HELA_Human0.94434957
186CDX2_20551321_ChIP-Seq_CACO-2_Human0.92712173
187TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.92630831
188DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92080689
189CTCF_27219007_Chip-Seq_Bcells_Human0.91209993
190SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90879309
191DROSHA_22980978_ChIP-Seq_HELA_Human0.90500086
192EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89462382
193FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.89005131
194NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.87863815
195NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.87143838
196KDM2B_26808549_Chip-Seq_JURKAT_Human0.85868479

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract7.87796255
2MP0003122_maternal_imprinting6.11364012
3MP0001666_abnormal_nutrient_absorption5.14714297
4MP0005220_abnormal_exocrine_pancreas4.56078622
5MP0003123_paternal_imprinting4.43767023
6MP0003283_abnormal_digestive_organ4.17092917
7MP0005084_abnormal_gallbladder_morpholo4.11926080
8MP0003868_abnormal_feces_composition4.09574964
9MP0005365_abnormal_bile_salt3.39341086
10MP0003705_abnormal_hypodermis_morpholog2.91089380
11MP0005085_abnormal_gallbladder_physiolo2.77430908
12MP0006054_spinal_hemorrhage2.71556492
13MP0010234_abnormal_vibrissa_follicle2.70586088
14MP0004264_abnormal_extraembryonic_tissu2.55378686
15MP0003121_genomic_imprinting2.45397576
16MP0010386_abnormal_urinary_bladder2.42043284
17MP0003195_calcinosis2.41759664
18MP0008438_abnormal_cutaneous_collagen2.38522340
19MP0003941_abnormal_skin_development2.34575955
20MP0001944_abnormal_pancreas_morphology2.07904739
21MP0002876_abnormal_thyroid_physiology2.01208796
22MP0003959_abnormal_lean_body1.74973832
23MP0003011_delayed_dark_adaptation1.73117137
24MP0003119_abnormal_digestive_system1.72109046
25MP0004272_abnormal_basement_membrane1.68815755
26MP0001664_abnormal_digestion1.67967793
27MP0009672_abnormal_birth_weight1.63697049
28MP0005623_abnormal_meninges_morphology1.61347975
29MP0004233_abnormal_muscle_weight1.50032543
30MP0002693_abnormal_pancreas_physiology1.48578708
31MP0009703_decreased_birth_body1.40728822
32MP0001873_stomach_inflammation1.39607476
33MP0002938_white_spotting1.39230380
34MP0008872_abnormal_physiological_respon1.38273191
35MP0002163_abnormal_gland_morphology1.38238745
36MP0003115_abnormal_respiratory_system1.36378754
37MP0008875_abnormal_xenobiotic_pharmacok1.36224921
38MP0005076_abnormal_cell_differentiation1.35722658
39MP0000537_abnormal_urethra_morphology1.35256040
40MP0003252_abnormal_bile_duct1.29014296
41MP0004197_abnormal_fetal_growth/weight/1.25593421
42MP0002928_abnormal_bile_duct1.24871686
43MP0008877_abnormal_DNA_methylation1.23995966
44MP0004147_increased_porphyrin_level1.23558785
45MP0005551_abnormal_eye_electrophysiolog1.20201970
46MP0003567_abnormal_fetal_cardiomyocyte1.19654658
47MP0003787_abnormal_imprinting1.16595311
48MP0005452_abnormal_adipose_tissue1.16233349
49MP0004043_abnormal_pH_regulation1.14559232
50MP0002102_abnormal_ear_morphology1.11713678
51MP0009384_cardiac_valve_regurgitation1.10929657
52MP0005646_abnormal_pituitary_gland1.08195197
53MP0002837_dystrophic_cardiac_calcinosis1.08136161
54MP0001501_abnormal_sleep_pattern1.07545023
55MP0003385_abnormal_body_wall1.07339100
56MP0002638_abnormal_pupillary_reflex1.06354507
57MP0006072_abnormal_retinal_apoptosis1.06186238
58MP0009780_abnormal_chondrocyte_physiolo1.02817803
59MP0001485_abnormal_pinna_reflex1.02511736
60MP0003942_abnormal_urinary_system1.02049392
61MP0005379_endocrine/exocrine_gland_phen1.01852877
62MP0008961_abnormal_basal_metabolism1.01351652
63MP0005645_abnormal_hypothalamus_physiol1.00170248
64MP0003953_abnormal_hormone_level0.99033859
65MP0002909_abnormal_adrenal_gland0.98221645
66MP0002139_abnormal_hepatobiliary_system0.97477703
67MP0002277_abnormal_respiratory_mucosa0.97449423
68MP0005253_abnormal_eye_physiology0.96420789
69MP0000470_abnormal_stomach_morphology0.94844171
70MP0008995_early_reproductive_senescence0.91099555
71MP0001502_abnormal_circadian_rhythm0.89736789
72MP0000462_abnormal_digestive_system0.89109154
73MP0005332_abnormal_amino_acid0.87303714
74MP0006276_abnormal_autonomic_nervous0.87278504
75MP0010678_abnormal_skin_adnexa0.83668199
76MP0005410_abnormal_fertilization0.81792402
77MP0000613_abnormal_salivary_gland0.81442655
78MP0005377_hearing/vestibular/ear_phenot0.81429599
79MP0003878_abnormal_ear_physiology0.81429599
80MP0003566_abnormal_cell_adhesion0.81211086
81MP0000003_abnormal_adipose_tissue0.79191795
82MP0000490_abnormal_crypts_of0.78598069
83MP0010329_abnormal_lipoprotein_level0.77317027
84MP0002896_abnormal_bone_mineralization0.76921325
85MP0001756_abnormal_urination0.76523478
86MP0004858_abnormal_nervous_system0.74891279
87MP0001968_abnormal_touch/_nociception0.74358532
88MP0001986_abnormal_taste_sensitivity0.73574506
89MP0001984_abnormal_olfaction0.73536947
90MP0003646_muscle_fatigue0.73534361
91MP0003950_abnormal_plasma_membrane0.73532842
92MP0001270_distended_abdomen0.72566152
93MP0000534_abnormal_ureter_morphology0.71728654
94MP0004134_abnormal_chest_morphology0.71091367
95MP0003693_abnormal_embryo_hatching0.69651223
96MP0001340_abnormal_eyelid_morphology0.68936116
97MP0004142_abnormal_muscle_tone0.68355620
98MP0004185_abnormal_adipocyte_glucose0.68176661
99MP0002272_abnormal_nervous_system0.67405974
100MP0002736_abnormal_nociception_after0.67401391
101MP0005408_hypopigmentation0.67241391
102MP0000631_abnormal_neuroendocrine_gland0.66744526
103MP0005636_abnormal_mineral_homeostasis0.65191011
104MP0005448_abnormal_energy_balance0.64764700
105MP0000428_abnormal_craniofacial_morphol0.64131296
106MP0003045_fibrosis0.62516694
107MP0002132_abnormal_respiratory_system0.62467946
108MP0009046_muscle_twitch0.62145640
109MP0002086_abnormal_extraembryonic_tissu0.62048453
110MP0005334_abnormal_fat_pad0.61728379
111MP0004885_abnormal_endolymph0.60190725
112MP0002138_abnormal_hepatobiliary_system0.59987572
113MP0005187_abnormal_penis_morphology0.59015682
114MP0002084_abnormal_developmental_patter0.58395037
115MP0004019_abnormal_vitamin_homeostasis0.58208562
116MP0009745_abnormal_behavioral_response0.57632607
117MP0003935_abnormal_craniofacial_develop0.55555933
118MP0006292_abnormal_olfactory_placode0.55302455
119MP0002118_abnormal_lipid_homeostasis0.54242638
120MP0001730_embryonic_growth_arrest0.51863229
121MP0000733_abnormal_muscle_development0.51691982
122MP0002078_abnormal_glucose_homeostasis0.50836928
123MP0003638_abnormal_response/metabolism_0.50206113
124MP0001849_ear_inflammation0.49928042
125MP0010030_abnormal_orbit_morphology0.49147966
126MP0003718_maternal_effect0.48766534
127MP0001845_abnormal_inflammatory_respons0.48461568
128MP0003943_abnormal_hepatobiliary_system0.48460767
129MP0000427_abnormal_hair_cycle0.47892977
130MP0002085_abnormal_embryonic_tissue0.47845030
131MP0008004_abnormal_stomach_pH0.47515664
132MP0002697_abnormal_eye_size0.47269694
133MP0004957_abnormal_blastocyst_morpholog0.47060035
134MP0001765_abnormal_ion_homeostasis0.46907232
135MP0001697_abnormal_embryo_size0.46697544
136MP0001293_anophthalmia0.46661699
137MP0002060_abnormal_skin_morphology0.46623995
138MP0000372_irregular_coat_pigmentation0.46588504
139MP0005275_abnormal_skin_tensile0.46505577
140MP0005319_abnormal_enzyme/_coenzyme0.46269037
141MP0002557_abnormal_social/conspecific_i0.45215882
142MP0000230_abnormal_systemic_arterial0.44413424
143MP0003300_gastrointestinal_ulcer0.43531317
144MP0000538_abnormal_urinary_bladder0.43523799
145MP0000013_abnormal_adipose_tissue0.42662116
146MP0001486_abnormal_startle_reflex0.41967634
147MP0005375_adipose_tissue_phenotype0.41856593
148MP0002069_abnormal_eating/drinking_beha0.41545597
149MP0002796_impaired_skin_barrier0.41315597
150MP0002282_abnormal_trachea_morphology0.41301225
151MP0001286_abnormal_eye_development0.41284418
152MP0002229_neurodegeneration0.40893977
153MP0001672_abnormal_embryogenesis/_devel0.40603025
154MP0005380_embryogenesis_phenotype0.40603025
155MP0009642_abnormal_blood_homeostasis0.40455907
156MP0000383_abnormal_hair_follicle0.40438858
157MP0009764_decreased_sensitivity_to0.39955209
158MP0004133_heterotaxia0.39863236
159MP0002925_abnormal_cardiovascular_devel0.39691661
160MP0002080_prenatal_lethality0.39579260
161MP0000350_abnormal_cell_proliferation0.39474930
162MP0002111_abnormal_tail_morphology0.38658881
163MP0000477_abnormal_intestine_morphology0.38603767
164MP0009643_abnormal_urine_homeostasis0.38467437
165MP0001731_abnormal_postnatal_growth0.37989038
166MP0000377_abnormal_hair_follicle0.37750005
167MP0000598_abnormal_liver_morphology0.37398721
168MP0010352_gastrointestinal_tract_polyps0.36827779
169MP0010630_abnormal_cardiac_muscle0.36504638
170MP0002088_abnormal_embryonic_growth/wei0.35391141

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the pancreatic islet cells (HP:0006476)5.28368174
2Abnormality of endocrine pancreas physiology (HP:0012093)5.28368174
3Asymmetry of the thorax (HP:0001555)5.10165548
4Pancreatitis (HP:0001733)4.82986538
5Hepatoblastoma (HP:0002884)4.36908666
6Lymphangioma (HP:0100764)4.06551062
7Absent eyelashes (HP:0000561)4.02692132
8Rectal prolapse (HP:0002035)3.97935967
9Abnormal pancreas size (HP:0012094)3.96773883
10Hypotension (HP:0002615)3.69413604
11Late onset (HP:0003584)3.60750477
12Renal duplication (HP:0000075)3.52471265
13Ketoacidosis (HP:0001993)3.43938602
14Pancreatic cysts (HP:0001737)3.41325968
15Pancreatic islet-cell hyperplasia (HP:0004510)3.38808221
16Type II lissencephaly (HP:0007260)3.34805264
17Exocrine pancreatic insufficiency (HP:0001738)3.33734506
18Diastasis recti (HP:0001540)3.29135988
19Abnormality of the renal cortex (HP:0011035)3.21774822
20Germ cell neoplasia (HP:0100728)3.09646749
21Enlarged penis (HP:0000040)3.09480027
22Steatorrhea (HP:0002570)3.05745704
23Abnormality of the pons (HP:0007361)3.02557279
24Abnormality of the pleura (HP:0002103)3.01545191
25Morphological abnormality of the middle ear (HP:0008609)2.98168509
26Congenital stationary night blindness (HP:0007642)2.96284154
27Thin bony cortex (HP:0002753)2.89240611
28Hypoproteinemia (HP:0003075)2.86138483
29Medial flaring of the eyebrow (HP:0010747)2.79472095
30Ankle contracture (HP:0006466)2.76647379
31Fat malabsorption (HP:0002630)2.75990693
32Cerebellar dysplasia (HP:0007033)2.66810877
33Gout (HP:0001997)2.66125742
34Abnormality of dentin (HP:0010299)2.64563735
35Ankyloglossia (HP:0010296)2.63153592
36Molar tooth sign on MRI (HP:0002419)2.62653520
37Abnormality of midbrain morphology (HP:0002418)2.62653520
38Methylmalonic acidemia (HP:0002912)2.59492323
39Cerebral aneurysm (HP:0004944)2.58740625
40Decreased electroretinogram (ERG) amplitude (HP:0000654)2.57980800
41Bladder diverticulum (HP:0000015)2.57462315
42Slender long bone (HP:0003100)2.57445522
43Abnormality of the renal medulla (HP:0100957)2.56241710
44Subacute progressive viral hepatitis (HP:0006572)2.56160972
45Absent eyebrow (HP:0002223)2.54483938
46Hypoplasia of the pons (HP:0012110)2.53431728
47Tubular atrophy (HP:0000092)2.50907046
48Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.50354117
49Abnormality of subcutaneous fat tissue (HP:0001001)2.50145279
50Renovascular hypertension (HP:0100817)2.49993536
51Short chin (HP:0000331)2.49578812
52Nephronophthisis (HP:0000090)2.48068744
53Protrusio acetabuli (HP:0003179)2.45177973
54Fragile skin (HP:0001030)2.45137379
55Pancreatic fibrosis (HP:0100732)2.41214660
56Type I transferrin isoform profile (HP:0003642)2.40923393
57Decreased subcutaneous fat (HP:0001002)2.40228698
58Mitral valve prolapse (HP:0001634)2.39931670
59True hermaphroditism (HP:0010459)2.39652287
60Type I diabetes mellitus (HP:0100651)2.38962989
61Premature rupture of membranes (HP:0001788)2.38459694
62Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.38130725
63Abnormal protein N-linked glycosylation (HP:0012347)2.38130725
64Abnormal protein glycosylation (HP:0012346)2.38130725
65Abnormal glycosylation (HP:0012345)2.38130725
66Ketosis (HP:0001946)2.35934751
67Pointed chin (HP:0000307)2.35152168
68Macroorchidism (HP:0000053)2.34750332
69Atrophic scars (HP:0001075)2.32209801
70Striae distensae (HP:0001065)2.30962245
71Bilateral microphthalmos (HP:0007633)2.30482880
72Attenuation of retinal blood vessels (HP:0007843)2.30116216
73Hyperacusis (HP:0010780)2.28608222
74Abnormal drinking behavior (HP:0030082)2.28389119
75Polydipsia (HP:0001959)2.28389119
76Cutaneous finger syndactyly (HP:0010554)2.28007268
77Abolished electroretinogram (ERG) (HP:0000550)2.24143014
78Abnormality of the pubic bones (HP:0003172)2.23049424
79Chronic hepatic failure (HP:0100626)2.21056185
80Shallow orbits (HP:0000586)2.21038387
81Right ventricular cardiomyopathy (HP:0011663)2.18506968
82Buphthalmos (HP:0000557)2.18303585
83Testicular neoplasm (HP:0010788)2.18248157
84Renal cortical cysts (HP:0000803)2.17092429
85Abnormality of the intrinsic pathway (HP:0010989)2.16874282
86Congenital primary aphakia (HP:0007707)2.16465719
87Methylmalonic aciduria (HP:0012120)2.15777748
88Insulin resistance (HP:0000855)2.13212796
89Aplasia/Hypoplasia of the sternum (HP:0006714)2.12801245
90Gait imbalance (HP:0002141)2.12554945
91Myelomeningocele (HP:0002475)2.12150795
92Bicornuate uterus (HP:0000813)2.10809444
93Insomnia (HP:0100785)2.10034315
94Pseudobulbar signs (HP:0002200)2.07212476
95Anal atresia (HP:0002023)2.05812448
96Bifid tongue (HP:0010297)2.05632549
97Cystic liver disease (HP:0006706)2.05540146
98Cutaneous syndactyly (HP:0012725)2.05380829
99Midline defect of the nose (HP:0004122)2.05218032
100Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.04986032
101Abnormality of alanine metabolism (HP:0010916)2.04986032
102Hyperalaninemia (HP:0003348)2.04986032
103Congenital, generalized hypertrichosis (HP:0004540)2.04391890
104Skull defect (HP:0001362)2.02909020
105Nephrogenic diabetes insipidus (HP:0009806)2.02604021
106Choanal stenosis (HP:0000452)2.02537190
107Enlarged kidneys (HP:0000105)2.02221423
108Abnormal rod and cone electroretinograms (HP:0008323)1.99604116
109Mildly elevated creatine phosphokinase (HP:0008180)1.98904192
110Tubulointerstitial fibrosis (HP:0005576)1.98581970
111Large for gestational age (HP:0001520)1.98241367
112Elfin facies (HP:0004428)1.96785632
113Mitochondrial inheritance (HP:0001427)1.96598069
114Abnormality of oral frenula (HP:0000190)1.95407799
115Abnormality of urine glucose concentration (HP:0011016)1.94519876
116Glycosuria (HP:0003076)1.94519876
117Aortic dissection (HP:0002647)1.94405013
118Maternal diabetes (HP:0009800)1.94187728
119Broad palm (HP:0001169)1.93254381
120Hypoglycemic coma (HP:0001325)1.92372214
121Protruding ear (HP:0000411)1.92365751
122Gaze-evoked nystagmus (HP:0000640)1.91199793
123Increased CSF lactate (HP:0002490)1.90276602
124Esophageal varix (HP:0002040)1.89544881
125Broad metatarsal (HP:0001783)1.88957765
126Acute necrotizing encephalopathy (HP:0006965)1.88331158
127Hypoventilation (HP:0002791)1.88128517
128Tubulointerstitial abnormality (HP:0001969)1.87932461
129Abnormality of vitamin B metabolism (HP:0004340)1.87004899
130Thoracolumbar scoliosis (HP:0002944)1.86692157
131Decreased central vision (HP:0007663)1.86093013
132Hyperinsulinemic hypoglycemia (HP:0000825)1.85785036
133Hyperglycemia (HP:0003074)1.85733992
134Abnormality of the common coagulation pathway (HP:0010990)1.85147194
135Exostoses (HP:0100777)1.84597548
136Acute encephalopathy (HP:0006846)1.84499963
137Optic nerve hypoplasia (HP:0000609)1.83683350
138Hydroxyprolinuria (HP:0003080)1.83524479
139Abnormality of proline metabolism (HP:0010907)1.83524479
140Aplasia/hypoplasia of the uterus (HP:0008684)1.82934657
141Reduced antithrombin III activity (HP:0001976)1.82672990
1423-Methylglutaconic aciduria (HP:0003535)1.81933541
143Micronodular cirrhosis (HP:0001413)1.80997067
144Blue sclerae (HP:0000592)1.80770510
145Severe muscular hypotonia (HP:0006829)1.80563919
146Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79932361
147Azoospermia (HP:0000027)1.79769307
148Bowel diverticulosis (HP:0005222)1.79007419
149Disproportionate tall stature (HP:0001519)1.78100580
150Back pain (HP:0003418)1.77468125
151Deep venous thrombosis (HP:0002625)1.76976956
152Genetic anticipation (HP:0003743)1.76474089
153Congenital sensorineural hearing impairment (HP:0008527)1.76417507
154Lissencephaly (HP:0001339)1.76092907
155Hepatocellular necrosis (HP:0001404)1.76085588
156Sprengel anomaly (HP:0000912)1.74542546
157Decreased circulating renin level (HP:0003351)1.73354303
158Congenital glaucoma (HP:0001087)1.73158679
159Hepatic necrosis (HP:0002605)1.72923076
160Abnormality of the vitamin B12 metabolism (HP:0004341)1.72786339
161Aneurysm (HP:0002617)1.72300248
162Polyuria (HP:0000103)1.71814865
163Type II diabetes mellitus (HP:0005978)1.71653514
164Congenital hepatic fibrosis (HP:0002612)1.70389281
165Thick eyebrow (HP:0000574)1.70384769
166Overriding aorta (HP:0002623)1.70249974
167Hyperglycinemia (HP:0002154)1.69818096
168Neonatal respiratory distress (HP:0002643)1.69188182
169Coronal craniosynostosis (HP:0004440)1.69088335
170Nephroblastoma (Wilms tumor) (HP:0002667)1.68325556
171Progressive cerebellar ataxia (HP:0002073)1.68116861
172Abnormal biliary tract morphology (HP:0012440)1.67554034
173Progressive macrocephaly (HP:0004481)1.67088322
174Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66645128
175Ventricular fibrillation (HP:0001663)1.66614776
176Abnormality of methionine metabolism (HP:0010901)1.65952108
177Hypothermia (HP:0002045)1.65236826
178Intestinal polyposis (HP:0200008)1.64951713
179Tubulointerstitial nephritis (HP:0001970)1.64248450
180Hypomagnesemia (HP:0002917)1.63805831
181Abnormality of renal excretion (HP:0011036)1.57946017
182Genital tract atresia (HP:0001827)1.57758112
183Aplasia/Hypoplasia of the tibia (HP:0005772)1.57677260
184Vaginal atresia (HP:0000148)1.57413172
185Abnormality of macular pigmentation (HP:0008002)1.55950273
186Poor coordination (HP:0002370)1.53682095
187Abnormal mitochondria in muscle tissue (HP:0008316)1.52476139
188Hypoplasia of the uterus (HP:0000013)1.52213085
189Lethargy (HP:0001254)1.51721574
190Abnormal biliary tract physiology (HP:0012439)1.51011769
191Bile duct proliferation (HP:0001408)1.51011769

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN27.13697821
2TRIB36.37518497
3GRK13.51886726
4BCKDK3.10438351
5LATS13.03414408
6MAP3K102.90765537
7PTK62.88472455
8BMPR1B2.81494073
9PASK2.61559178
10PDK22.60336880
11ADRBK22.58051009
12MAP4K22.53016369
13EEF2K2.36337446
14STK392.35270891
15RIPK12.27439493
16ERN12.21043583
17RPS6KB22.17918353
18PDGFRA2.15944162
19OXSR12.00237651
20FLT31.97320818
21PINK11.96835680
22LRRK21.84632554
23WNK31.81518320
24NME11.81308116
25MST41.78494877
26STK161.67053532
27PAK41.65330078
28ACVR1B1.64070550
29TXK1.62984974
30SCYL21.62538953
31PAK21.58819773
32MAP2K21.51555979
33EPHA21.50712423
34NUAK11.45015567
35MAP3K41.41081367
36CAMKK11.36511555
37RET1.35247754
38TRIM281.35135172
39PRKCE1.30121933
40PTK21.29436626
41MET1.26640467
42MAPKAPK31.25059175
43DDR21.23482275
44IRAK11.20865604
45FER1.19576802
46PDGFRB1.19360899
47ILK1.18336574
48CASK1.16249029
49MAP3K21.15899574
50STK38L1.15453320
51CDK41.15361336
52ZAK1.15287611
53TAOK31.14127424
54MTOR1.11018228
55NLK1.08506396
56ERBB21.04918205
57MAP3K31.01885194
58EIF2AK31.01493948
59PRKD30.98029630
60WNK40.94040376
61TLK10.89481085
62TIE10.88617752
63ERBB30.87831912
64MAPK130.86645021
65NTRK10.84189323
66KSR20.82966375
67FGFR10.82658418
68INSRR0.81237357
69STK30.80530730
70ALK0.79477746
71PRKCQ0.77729765
72CDK60.77044943
73LATS20.77005811
74CDK190.76695892
75MAP3K80.76191441
76PAK30.76119902
77FGFR40.75904019
78ADRBK10.75787377
79MAP3K120.73905667
80EPHA30.73340201
81PRKG20.73278000
82CAMKK20.70875650
83SIK10.70514629
84SRPK10.70450700
85DYRK1B0.69741069
86BRSK20.69338777
87FRK0.68184916
88MAP2K70.68107056
89MAP2K10.66404705
90DYRK20.64541038
91MAP2K60.64517217
92WNK10.63279563
93PRKCG0.62859118
94HIPK20.60718543
95CSNK1E0.59178072
96LMTK20.58319259
97ICK0.58179055
98EIF2AK10.58098411
99IKBKB0.57740567
100TNIK0.57532463
101NEK60.56515482
102VRK10.54964355
103PHKG20.54470436
104PHKG10.54470436
105UHMK10.54108109
106MUSK0.52651157
107NEK10.52375013
108TEC0.51438912
109TAOK10.51223258
110TRPM70.51219220
111ZAP700.50991346
112MKNK20.50485307
113PIK3CA0.50446120
114TGFBR10.49676599
115CSNK1A10.48107940
116TGFBR20.48093083
117PRKCH0.48084997
118PLK20.47209733
119PRKCI0.46818447
120DAPK20.45865174
121MELK0.45684226
122CSNK1A1L0.45335620
123PRKACA0.45328082
124AKT20.43311568
125CSNK1G10.43300368
126BCR0.42791200
127TTN0.41660901
128RPS6KA50.41638023
129PRKD10.41420615
130MST1R0.41142265
131PRKCA0.40932379
132MAP3K70.40437574
133TTK0.40004518
134CSNK1D0.37438294
135GSK3A0.37405123
136PRKDC0.36711894
137PIM20.35511807
138CHUK0.35352647
139MAP3K10.35265571
140CSNK1G20.34666468
141EPHB20.33477980
142CAMK2A0.33450805
143SRC0.33293708
144CSNK1G30.32876838
145PRKAA10.32866958
146MAPK10.32424525
147ROCK10.31705836
148PRKACB0.31407502
149SGK20.31198995
150STK240.30697017
151SGK2230.30259214
152SGK4940.30259214
153TSSK60.29057742
154MAPK90.28683721
155CDK120.27039253
156TYRO30.26959958
157CHEK10.26936858
158AKT10.26688520
159WEE10.26552257
160IGF1R0.26322190
161KIT0.26267615
162OBSCN0.26233819
163KSR10.25767600
164FYN0.25299205
165LIMK10.25092623
166MARK30.24993422
167CDK80.24880504
168NEK20.24788382
169NEK90.24689068
170MAPK150.24645344
171TBK10.24552654
172CDK20.23405549
173MAPK110.23105658
174RPS6KA10.22573902
175MAPK140.21805913
176NTRK30.21273482

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.32440202
2* Pancreatic secretion_Homo sapiens_hsa049726.97768153
3Protein digestion and absorption_Homo sapiens_hsa049745.86113230
4* Fat digestion and absorption_Homo sapiens_hsa049753.29389562
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.19359690
6Linoleic acid metabolism_Homo sapiens_hsa005912.74499977
7Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.63742761
8Vitamin digestion and absorption_Homo sapiens_hsa049772.34949438
9Protein export_Homo sapiens_hsa030602.18502304
10Ether lipid metabolism_Homo sapiens_hsa005651.83059723
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.80625085
12Notch signaling pathway_Homo sapiens_hsa043301.70532662
13N-Glycan biosynthesis_Homo sapiens_hsa005101.58905980
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52172354
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.51349699
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39785967
17Insulin secretion_Homo sapiens_hsa049111.36609177
18Nitrogen metabolism_Homo sapiens_hsa009101.33948824
19Arachidonic acid metabolism_Homo sapiens_hsa005901.33452975
20* Glycerolipid metabolism_Homo sapiens_hsa005611.33075961
21Lysine degradation_Homo sapiens_hsa003101.10857606
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07127007
23Phototransduction_Homo sapiens_hsa047441.07061796
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04396828
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99617423
26Fatty acid degradation_Homo sapiens_hsa000710.99385065
27Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97835608
28Thyroid cancer_Homo sapiens_hsa052160.97471055
29Adherens junction_Homo sapiens_hsa045200.96503559
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94422317
31Tight junction_Homo sapiens_hsa045300.94005010
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93642125
33Selenocompound metabolism_Homo sapiens_hsa004500.91486144
34Steroid biosynthesis_Homo sapiens_hsa001000.85304945
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82563534
36Steroid hormone biosynthesis_Homo sapiens_hsa001400.82186968
37Estrogen signaling pathway_Homo sapiens_hsa049150.81570067
38Oxidative phosphorylation_Homo sapiens_hsa001900.81345621
39Chemical carcinogenesis_Homo sapiens_hsa052040.80939182
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80373444
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79354813
42Biosynthesis of amino acids_Homo sapiens_hsa012300.78068045
43Tryptophan metabolism_Homo sapiens_hsa003800.78061494
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77699480
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77623091
46Cyanoamino acid metabolism_Homo sapiens_hsa004600.77366585
47Arginine and proline metabolism_Homo sapiens_hsa003300.76783886
48Thyroid hormone synthesis_Homo sapiens_hsa049180.76488008
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75665623
50Bladder cancer_Homo sapiens_hsa052190.73070386
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72624970
52Hippo signaling pathway_Homo sapiens_hsa043900.70310533
53Propanoate metabolism_Homo sapiens_hsa006400.69530910
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69071887
55Endometrial cancer_Homo sapiens_hsa052130.68622799
56One carbon pool by folate_Homo sapiens_hsa006700.67936646
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67399914
58Retinol metabolism_Homo sapiens_hsa008300.65469981
59ECM-receptor interaction_Homo sapiens_hsa045120.65090711
60Circadian rhythm_Homo sapiens_hsa047100.64240093
61Starch and sucrose metabolism_Homo sapiens_hsa005000.61834523
62Glutathione metabolism_Homo sapiens_hsa004800.61795854
63Folate biosynthesis_Homo sapiens_hsa007900.61626321
64Proteasome_Homo sapiens_hsa030500.61379389
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61142638
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60284678
67Peroxisome_Homo sapiens_hsa041460.58910159
68RNA polymerase_Homo sapiens_hsa030200.58649605
69Focal adhesion_Homo sapiens_hsa045100.57416233
70Histidine metabolism_Homo sapiens_hsa003400.56106464
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54612327
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54411488
73Sulfur metabolism_Homo sapiens_hsa009200.53707230
74beta-Alanine metabolism_Homo sapiens_hsa004100.53609666
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53423448
76Ribosome_Homo sapiens_hsa030100.52806443
77Cocaine addiction_Homo sapiens_hsa050300.51577541
78Regulation of autophagy_Homo sapiens_hsa041400.50930181
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50644183
80Platelet activation_Homo sapiens_hsa046110.50491991
81Vibrio cholerae infection_Homo sapiens_hsa051100.50434472
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49924079
83Chronic myeloid leukemia_Homo sapiens_hsa052200.49804314
84mTOR signaling pathway_Homo sapiens_hsa041500.49391859
85Parkinsons disease_Homo sapiens_hsa050120.49287551
86Axon guidance_Homo sapiens_hsa043600.48844140
87Proteoglycans in cancer_Homo sapiens_hsa052050.46880670
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.46765499
89Gap junction_Homo sapiens_hsa045400.45473487
90Gastric acid secretion_Homo sapiens_hsa049710.44968094
91Type II diabetes mellitus_Homo sapiens_hsa049300.44773913
92Insulin resistance_Homo sapiens_hsa049310.44652911
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44408185
94* Metabolic pathways_Homo sapiens_hsa011000.44027785
95Caffeine metabolism_Homo sapiens_hsa002320.42887802
96Vitamin B6 metabolism_Homo sapiens_hsa007500.42285463
97Small cell lung cancer_Homo sapiens_hsa052220.41827740
98Mineral absorption_Homo sapiens_hsa049780.41622050
99Pyruvate metabolism_Homo sapiens_hsa006200.40895433
100Rap1 signaling pathway_Homo sapiens_hsa040150.40686397
101Renin secretion_Homo sapiens_hsa049240.40008309
102Bile secretion_Homo sapiens_hsa049760.39766721
103Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39223346
104Primary bile acid biosynthesis_Homo sapiens_hsa001200.38610737
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38509425
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.38152625
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37358762
108VEGF signaling pathway_Homo sapiens_hsa043700.36958442
109Prostate cancer_Homo sapiens_hsa052150.35834047
110Melanogenesis_Homo sapiens_hsa049160.35662492
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35249813
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.35175796
113ABC transporters_Homo sapiens_hsa020100.34045558
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.33940372
115Basal transcription factors_Homo sapiens_hsa030220.33843391
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32687879
117Viral myocarditis_Homo sapiens_hsa054160.32345560
118Prion diseases_Homo sapiens_hsa050200.32212893
119Renin-angiotensin system_Homo sapiens_hsa046140.31936229
120Influenza A_Homo sapiens_hsa051640.31652865
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31334066
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.30880476
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30005687
124Nicotine addiction_Homo sapiens_hsa050330.29981044
125Glucagon signaling pathway_Homo sapiens_hsa049220.29149066
126Colorectal cancer_Homo sapiens_hsa052100.29136754
127Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.29116321
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28987434
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28938147
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28393293
131Alzheimers disease_Homo sapiens_hsa050100.27800205
132Carbon metabolism_Homo sapiens_hsa012000.27686612
133Amoebiasis_Homo sapiens_hsa051460.27172870
134Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.26766241
135Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26027946
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25847395
137Collecting duct acid secretion_Homo sapiens_hsa049660.25678467
138Cysteine and methionine metabolism_Homo sapiens_hsa002700.25609798
139Butanoate metabolism_Homo sapiens_hsa006500.25536024
140Cholinergic synapse_Homo sapiens_hsa047250.25398998
141Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25129476
142Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24934835
143Insulin signaling pathway_Homo sapiens_hsa049100.24613784
144Ovarian steroidogenesis_Homo sapiens_hsa049130.24415138
145Oocyte meiosis_Homo sapiens_hsa041140.23363261
146Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23211903
147RNA degradation_Homo sapiens_hsa030180.23117245
148SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22755400
149Type I diabetes mellitus_Homo sapiens_hsa049400.22676764
150Huntingtons disease_Homo sapiens_hsa050160.22622800
151Taste transduction_Homo sapiens_hsa047420.22301424
152Vascular smooth muscle contraction_Homo sapiens_hsa042700.21491918
153Sphingolipid metabolism_Homo sapiens_hsa006000.19851497
154Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.18912408
155Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.18697261
156Olfactory transduction_Homo sapiens_hsa047400.16867024
157Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.16698754
158Intestinal immune network for IgA production_Homo sapiens_hsa046720.15206024
159Rheumatoid arthritis_Homo sapiens_hsa053230.11897283
160GABAergic synapse_Homo sapiens_hsa047270.11444423
161Fatty acid elongation_Homo sapiens_hsa000620.10059630
162Fatty acid metabolism_Homo sapiens_hsa012120.09720924
163Homologous recombination_Homo sapiens_hsa034400.08884346
164Non-homologous end-joining_Homo sapiens_hsa034500.08868187
165Jak-STAT signaling pathway_Homo sapiens_hsa046300.07035238
166Cardiac muscle contraction_Homo sapiens_hsa042600.05956784

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »