ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	intestinal absorption (GO:0050892)	8.99034313
2	transcytosis (GO:0045056)	8.61862251
3	cobalamin metabolic process (GO:0009235)	8.06213332
4	daunorubicin metabolic process (GO:0044597)	7.49190881
5	polyketide metabolic process (GO:0030638)	7.49190881
6	doxorubicin metabolic process (GO:0044598)	7.49190881
7	peptidyl-proline hydroxylation (GO:0019511)	7.46011260
8	cholesterol catabolic process (GO:0006707)	7.41665590
9	sterol catabolic process (GO:0016127)	7.41665590
10	regulation of phospholipase A2 activity (GO:0032429)	7.11674683
11	negative regulation of digestive system process (GO:0060457)	6.91079893
12	aminoglycoside antibiotic metabolic process (GO:0030647)	6.74254921
13	negative regulation of epidermis development (GO:0045683)	6.40028275
14	cysteine metabolic process (GO:0006534)	6.16436360
15	Golgi transport vesicle coating (GO:0048200)	5.79000021
16	COPI coating of Golgi vesicle (GO:0048205)	5.79000021
17	protein hydroxylation (GO:0018126)	5.75076944
18	proline biosynthetic process (GO:0006561)	5.59479036
19	branched-chain amino acid catabolic process (GO:0009083)	5.46040486
20	ceramide catabolic process (GO:0046514)	5.43394359
21	regulation of triglyceride catabolic process (GO:0010896)	5.33934555
22	valine metabolic process (GO:0006573)	5.23112183
23	tetrapyrrole metabolic process (GO:0033013)	5.14723273
24	intestinal epithelial cell development (GO:0060576)	4.87324926
25	regulation of keratinocyte differentiation (GO:0045616)	4.86351585
26	activation of signaling protein activity involved in unfolded protein response (GO:0006987)	4.83321703
27	branched-chain amino acid metabolic process (GO:0009081)	4.78250814
28	cellular modified amino acid catabolic process (GO:0042219)	4.74062851
29	leukotriene biosynthetic process (GO:0019370)	4.68759457
30	zinc ion transport (GO:0006829)	4.67333462
31	glycoside metabolic process (GO:0016137)	4.62024440
32	positive regulation of nuclease activity (GO:0032075)	4.61729406
33	regulation of keratinocyte proliferation (GO:0010837)	4.60587377
34	protein maturation by protein folding (GO:0022417)	4.51691205
35	mitochondrial calcium ion transport (GO:0006851)	4.51668396
36	response to endoplasmic reticulum stress (GO:0034976)	4.46132185
37	angiotensin maturation (GO:0002003)	4.45924305
38	homocysteine metabolic process (GO:0050667)	4.37250334
39	endoplasmic reticulum unfolded protein response (GO:0030968)	4.34413378
40	serine family amino acid biosynthetic process (GO:0009070)	4.32875825
41	antibacterial humoral response (GO:0019731)	4.30721812
42	cellular response to unfolded protein (GO:0034620)	4.22416256
43	regulation of nuclease activity (GO:0032069)	4.20138243
44	maintenance of protein localization in organelle (GO:0072595)	4.19631437
45	signal peptide processing (GO:0006465)	4.15295417
46	4-hydroxyproline metabolic process (GO:0019471)	4.09742715
47	neutrophil mediated immunity (GO:0002446)	4.09459726
48	GDP-mannose metabolic process (GO:0019673)	4.05076787
49	regulation of guanylate cyclase activity (GO:0031282)	4.04074621
50	antimicrobial humoral response (GO:0019730)	4.03441422
51	primary alcohol catabolic process (GO:0034310)	4.01683592
52	cellular response to topologically incorrect protein (GO:0035967)	4.01330382
53	positive regulation of heat generation (GO:0031652)	4.00612269
54	ER-nucleus signaling pathway (GO:0006984)	4.00327733
55	aspartate family amino acid catabolic process (GO:0009068)	3.94832442
56	COPII vesicle coating (GO:0048208)	3.94349622
57	water-soluble vitamin metabolic process (GO:0006767)	3.91727245
58	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	3.84062391
59	glutamine metabolic process (GO:0006541)	3.81838792
60	regulation of bile acid biosynthetic process (GO:0070857)	3.80514774
61	regulation of fever generation (GO:0031620)	3.79561317
62	steroid catabolic process (GO:0006706)	3.76754544
63	progesterone metabolic process (GO:0042448)	3.74698914
64	proline metabolic process (GO:0006560)	3.73352648
65	mucosal immune response (GO:0002385)	3.72381691
66	endocrine pancreas development (GO:0031018)	3.71658149
67	cellular glucuronidation (GO:0052695)	3.70136098
68	phosphatidylserine metabolic process (GO:0006658)	3.66351764
69	glucuronate metabolic process (GO:0019585)	3.64520407
70	uronic acid metabolic process (GO:0006063)	3.64520407
71	digestive system process (GO:0022600)	3.63204110
72	icosanoid secretion (GO:0032309)	3.61096826
73	arachidonic acid secretion (GO:0050482)	3.61096826
74	ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)	3.60144227
75	phosphatidylcholine acyl-chain remodeling (GO:0036151)	3.59686378
76	cellular protein catabolic process (GO:0044257)	3.55901003
77	sphingolipid catabolic process (GO:0030149)	3.55276495
78	negative regulation of epidermal cell differentiation (GO:0045605)	3.54362653
79	creatine metabolic process (GO:0006600)	3.54055014
80	ER overload response (GO:0006983)	3.53813080
81	positive regulation of guanylate cyclase activity (GO:0031284)	3.51001359
82	coenzyme catabolic process (GO:0009109)	3.50529058
83	regulation of cholesterol homeostasis (GO:2000188)	3.49958831
84	response to unfolded protein (GO:0006986)	3.47894416
85	cyclooxygenase pathway (GO:0019371)	3.47521345
86	retinoid metabolic process (GO:0001523)	3.46144632
87	retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)	3.42257937
88	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	3.41381042
89	L-serine metabolic process (GO:0006563)	3.39385072
90	phosphatidic acid metabolic process (GO:0046473)	3.38549175
91	phosphatidic acid biosynthetic process (GO:0006654)	3.38549175
92	organ or tissue specific immune response (GO:0002251)	3.37922101
93	sterol transport (GO:0015918)	3.36494403
94	cholesterol transport (GO:0030301)	3.36494403
95	* membrane lipid catabolic process (GO:0046466)	3.35855365
96	response to topologically incorrect protein (GO:0035966)	3.34901583
97	protein N-linked glycosylation via asparagine (GO:0018279)	3.34790911
98	peptidyl-asparagine modification (GO:0018196)	3.32660050
99	serine family amino acid metabolic process (GO:0009069)	3.31371349
100	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	3.31368631
101	vitamin metabolic process (GO:0006766)	3.31323372
102	diterpenoid metabolic process (GO:0016101)	3.28075872
103	alditol phosphate metabolic process (GO:0052646)	3.23695311
104	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.22502257
105	L-phenylalanine catabolic process (GO:0006559)	3.22502257
106	innate immune response in mucosa (GO:0002227)	3.20804053
107	macroautophagy (GO:0016236)	3.18613225
108	mitochondrion distribution (GO:0048311)	3.17864904
109	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.17252672
110	negative regulation of hormone metabolic process (GO:0032351)	3.12123193
111	cell redox homeostasis (GO:0045454)	3.10277173
112	myeloid leukocyte mediated immunity (GO:0002444)	3.08409821
113	L-alpha-amino acid transmembrane transport (GO:1902475)	3.07646880
114	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.07565475
115	L-phenylalanine metabolic process (GO:0006558)	3.07565475
116	regulation of digestive system process (GO:0044058)	3.07016254
117	regulation of vitamin metabolic process (GO:0030656)	3.06828048
118	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)	3.06439482
119	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	3.05648447
120	acute-phase response (GO:0006953)	3.05511979
121	protein N-linked glycosylation (GO:0006487)	3.05184402
122	positive regulation of triglyceride metabolic process (GO:0090208)	3.05069850
123	quinone metabolic process (GO:1901661)	3.02736765
124	positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:00360	3.01506569
125	regulation of epidermal cell differentiation (GO:0045604)	3.00876362
126	biotin metabolic process (GO:0006768)	3.00828339
127	sulfur amino acid biosynthetic process (GO:0000097)	3.00739814
128	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.99185434
129	regulation of heat generation (GO:0031650)	2.98173477
130	fatty acid derivative transport (GO:1901571)	2.97045502
131	icosanoid transport (GO:0071715)	2.97045502
132	peptide catabolic process (GO:0043171)	2.96416948
133	terpenoid metabolic process (GO:0006721)	2.93443341
134	multicellular organismal catabolic process (GO:0044243)	2.93343161
135	glycine transport (GO:0015816)	2.92355967
136	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.90496727
137	defense response to Gram-positive bacterium (GO:0050830)	2.89126665
138	leukotriene metabolic process (GO:0006691)	2.87785589
139	renal absorption (GO:0070293)	2.87534291
140	endothelial cell migration (GO:0043542)	2.84130469
141	regulation of oxidative stress-induced cell death (GO:1903201)	2.83009318
142	nucleotide-sugar biosynthetic process (GO:0009226)	2.81974876
143	NADH metabolic process (GO:0006734)	2.81947755
144	multicellular organismal metabolic process (GO:0044236)	2.81451013
145	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.79825660
146	negative regulation of cell fate commitment (GO:0010454)	2.78076117
147	positive regulation of lipid catabolic process (GO:0050996)	2.75103585
148	phototransduction, visible light (GO:0007603)	2.71411592
149	epoxygenase P450 pathway (GO:0019373)	2.70543830
150	L-ascorbic acid metabolic process (GO:0019852)	2.70163739
151	negative regulation of epithelial cell differentiation (GO:0030857)	2.67367342
152	retinal metabolic process (GO:0042574)	2.62862098
153	regulation of systemic arterial blood pressure by hormone (GO:0001990)	2.61720305
154	regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	2.61720305
155	endocrine process (GO:0050886)	2.61720305
156	phosphatidylglycerol metabolic process (GO:0046471)	2.60505752
157	fat-soluble vitamin biosynthetic process (GO:0042362)	2.58999934
158	intestinal cholesterol absorption (GO:0030299)	18.9064831
159	exocrine pancreas development (GO:0031017)	15.7186113
160	* digestion (GO:0007586)	13.4351324
161	protein retention in ER lumen (GO:0006621)	12.3379279
162	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	11.5239104

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	7.96455102
2	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	4.08073483
3	STAT6_21828071_ChIP-Seq_BEAS2B_Human	3.95810114
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.57765595
5	SOX2_27498859_Chip-Seq_STOMACH_Mouse	3.05480287
6	GATA4_25053715_ChIP-Seq_YYC3_Human	2.94787860
7	ERG_21242973_ChIP-ChIP_JURKAT_Human	2.86736628
8	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	2.83288521
9	PPARA_22158963_ChIP-Seq_LIVER_Mouse	2.81043167
10	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.75438304
11	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.69271578
12	GATA6_25053715_ChIP-Seq_YYC3_Human	2.44966067
13	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.38000533
14	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.36018033
15	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.25090425
16	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	2.24286918
17	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	2.20742305
18	GATA1_22025678_ChIP-Seq_K562_Human	2.16421954
19	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.15980475
20	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.12535273
21	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.12535273
22	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.12535273
23	HTT_18923047_ChIP-ChIP_STHdh_Human	2.00944620
24	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.85663452
25	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.82572934
26	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.71273447
27	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.68662639
28	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.67313409
29	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.64840850
30	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.64143080
31	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.61279842
32	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.60461569
33	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.60296564
34	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.58071984
35	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.55068297
36	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.53989798
37	NFYA_21822215_ChIP-Seq_K562_Human	1.53094073
38	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.52410201
39	EGR1_19032775_ChIP-ChIP_M12_Human	1.50332255
40	ETV1_20927104_ChIP-Seq_GIST48_Human	1.49460865
41	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.48954876
42	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.44731166
43	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.44728816
44	CREB1_26743006_Chip-Seq_LNCaP_Human	1.44212277
45	SOX2_20726797_ChIP-Seq_SW620_Human	1.43907064
46	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.43738065
47	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.42593704
48	PHF8_20622853_ChIP-Seq_HELA_Human	1.42215928
49	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.42209114
50	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.41914343
51	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.40069866
52	* HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.39994133
53	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.39303806
54	CHD1_26751641_Chip-Seq_LNCaP_Human	1.37411423
55	RBPJ_21746931_ChIP-Seq_IB4_Human	1.35711569
56	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.34577359
57	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.33147058
58	LXR_22292898_ChIP-Seq_THP-1_Human	1.30799270
59	P68_20966046_ChIP-Seq_HELA_Human	1.29753675
60	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.28145946
61	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.28127312
62	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.26391638
63	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.25583128
64	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.24354785
65	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.22482105
66	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.21687035
67	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.21467285
68	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.20960879
69	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.20468590
70	* ATF3_27146783_Chip-Seq_COLON_Human	1.19072029
71	NFYB_21822215_ChIP-Seq_K562_Human	1.18235883
72	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.15270723
73	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.15095303
74	CEBPB_22108803_ChIP-Seq_LS180_Human	1.14419678
75	TP63_22573176_ChIP-Seq_HFKS_Human	1.14191058
76	CLOCK_20551151_ChIP-Seq_293T_Human	1.11802180
77	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.11211036
78	ESET_19884257_ChIP-Seq_ESCs_Mouse	1.10889491
79	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.10822455
80	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.09980693
81	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.09757283
82	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.09291032
83	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	1.08222240
84	CDX2_22108803_ChIP-Seq_LS180_Human	1.08027450
85	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.07441843
86	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.07386280
87	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.07225712
88	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.07172647
89	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.06593419
90	ERA_21632823_ChIP-Seq_H3396_Human	1.06584175
91	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.06296942
92	RACK7_27058665_Chip-Seq_MCF-7_Human	1.06228178
93	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.05184023
94	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.03962788
95	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.02091322
96	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.01974871
97	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.01036520
98	BCOR_27268052_Chip-Seq_Bcells_Human	1.01017822
99	ERG_20517297_ChIP-Seq_VCAP_Human	1.00887014
100	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.00839484
101	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.00465458
102	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.99921455
103	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	0.98540268
104	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.97467519
105	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.97220815
106	KLF5_25053715_ChIP-Seq_YYC3_Human	0.96932110
107	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.94783891
108	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.94252623
109	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.94000049
110	P53_21459846_ChIP-Seq_SAOS-2_Human	0.93498974
111	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.93378235
112	OCT4_20526341_ChIP-Seq_ESCs_Human	0.93060658
113	TBL1_22424771_ChIP-Seq_293T_Human	0.92217042
114	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.91819784
115	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.90716321
116	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.90511772
117	GATA3_21867929_ChIP-Seq_CD8_Mouse	0.89067184
118	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.88850417
119	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.88291526
120	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.87628425
121	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.87415812
122	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.86000106
123	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.85405930
124	CTCF_20526341_ChIP-Seq_ESCs_Human	0.85297259
125	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	0.85165687
126	* CBP_21632823_ChIP-Seq_H3396_Human	0.84679238
127	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.84652330
128	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.83012131
129	SA1_27219007_Chip-Seq_Bcells_Human	0.82993367
130	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.82893512
131	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	0.82101277
132	IRF1_19129219_ChIP-ChIP_H3396_Human	0.82058763
133	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.81650079
134	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.81580668
135	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.81415642
136	SOX3_22085726_ChIP-Seq_MUSCLE_Mouse	0.80774764
137	* ETS1_21867929_ChIP-Seq_TH2_Mouse	0.80713243
138	CJUN_26792858_Chip-Seq_BT549_Human	0.80211355
139	SOX2_21211035_ChIP-Seq_LN229_Human	0.79347797
140	* TAF2_19829295_ChIP-Seq_ESCs_Human	0.79232132
141	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.79188960
142	AR_20517297_ChIP-Seq_VCAP_Human	0.78675954
143	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.78421994
144	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.77847898
145	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	0.77121931
146	FLI1_21867929_ChIP-Seq_CD8_Mouse	0.77043447
147	P300_27268052_Chip-Seq_Bcells_Human	0.76805839
148	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.76662428
149	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.76451487
150	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.76199020
151	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	0.74700190

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005083_abnormal_biliary_tract	9.32213740
2	* MP0001666_abnormal_nutrient_absorption	8.41194906
3	MP0005365_abnormal_bile_salt	6.62489344
4	MP0005220_abnormal_exocrine_pancreas	6.29415171
5	MP0003868_abnormal_feces_composition	5.07838354
6	MP0005084_abnormal_gallbladder_morpholo	5.03490021
7	MP0005085_abnormal_gallbladder_physiolo	3.65147262
8	MP0001664_abnormal_digestion	2.85978259
9	MP0002693_abnormal_pancreas_physiology	2.66246465
10	MP0008004_abnormal_stomach_pH	2.62236330
11	MP0003959_abnormal_lean_body	2.49992515
12	MP0002139_abnormal_hepatobiliary_system	2.40790481
13	MP0004264_abnormal_extraembryonic_tissu	2.13217554
14	MP0009840_abnormal_foam_cell	2.08155874
15	MP0002138_abnormal_hepatobiliary_system	2.06484443
16	MP0004019_abnormal_vitamin_homeostasis	2.03398553
17	MP0010234_abnormal_vibrissa_follicle	1.97838864
18	MP0003705_abnormal_hypodermis_morpholog	1.94260376
19	MP0001944_abnormal_pancreas_morphology	1.79867279
20	MP0005448_abnormal_energy_balance	1.73249449
21	MP0010386_abnormal_urinary_bladder	1.66898146
22	MP0003252_abnormal_bile_duct	1.56162392
23	MP0003638_abnormal_response/metabolism_	1.42947880
24	MP0004233_abnormal_muscle_weight	1.40481663
25	MP0004147_increased_porphyrin_level	1.33923778
26	MP0002277_abnormal_respiratory_mucosa	1.33258192
27	MP0000470_abnormal_stomach_morphology	1.31880401
28	MP0005165_increased_susceptibility_to	1.29542729
29	MP0005332_abnormal_amino_acid	1.28177140
30	MP0001873_stomach_inflammation	1.23916003
31	* MP0002118_abnormal_lipid_homeostasis	1.23401544
32	MP0005451_abnormal_body_composition	1.16788310
33	MP0005360_urolithiasis	1.11799300
34	MP0003866_abnormal_defecation	1.11088639
35	MP0002928_abnormal_bile_duct	1.09461922
36	MP0002078_abnormal_glucose_homeostasis	1.02785832
37	MP0000490_abnormal_crypts_of	0.96759277
38	MP0010352_gastrointestinal_tract_polyps	0.95199097
39	MP0000538_abnormal_urinary_bladder	0.93031426
40	MP0005408_hypopigmentation	0.90040984
41	MP0003806_abnormal_nucleotide_metabolis	0.89916549
42	MP0009643_abnormal_urine_homeostasis	0.89600846
43	MP0003879_abnormal_hair_cell	0.89312212
44	MP0002132_abnormal_respiratory_system	0.88312120
45	MP0000003_abnormal_adipose_tissue	0.87723046
46	MP0001501_abnormal_sleep_pattern	0.86487753
47	MP0006054_spinal_hemorrhage	0.84937891
48	MP0003195_calcinosis	0.84619801
49	MP0001663_abnormal_digestive_system	0.84110345
50	MP0009384_cardiac_valve_regurgitation	0.82863618
51	MP0010329_abnormal_lipoprotein_level	0.81728751
52	MP0005166_decreased_susceptibility_to	0.80808624
53	MP0003953_abnormal_hormone_level	0.79491385
54	MP0005670_abnormal_white_adipose	0.77961240
55	MP0002163_abnormal_gland_morphology	0.76762835
56	MP0005535_abnormal_body_temperature	0.76581967
57	MP0009379_abnormal_foot_pigmentation	0.74278635
58	MP0008789_abnormal_olfactory_epithelium	0.73264611
59	MP0002822_catalepsy	0.72010551
60	MP0005381_digestive/alimentary_phenotyp	0.71508045
61	MP0000613_abnormal_salivary_gland	0.68896742
62	MP0008961_abnormal_basal_metabolism	0.67812515
63	MP0005058_abnormal_lysosome_morphology	0.66570407
64	MP0003045_fibrosis	0.64983263
65	MP0003300_gastrointestinal_ulcer	0.64748215
66	MP0002136_abnormal_kidney_physiology	0.64607801
67	MP0000477_abnormal_intestine_morphology	0.63812143
68	MP0005452_abnormal_adipose_tissue	0.62338709
69	MP0001764_abnormal_homeostasis	0.61212412
70	MP0000598_abnormal_liver_morphology	0.60075254
71	MP0003183_abnormal_peptide_metabolism	0.56630747
72	MP0002098_abnormal_vibrissa_morphology	0.55659179
73	MP0000609_abnormal_liver_physiology	0.55419963
74	MP0002909_abnormal_adrenal_gland	0.55346386
75	MP0002796_impaired_skin_barrier	0.55181546
76	MP0008438_abnormal_cutaneous_collagen	0.55118002
77	MP0003283_abnormal_digestive_organ	0.55081529
78	MP0006036_abnormal_mitochondrial_physio	0.54655389
79	MP0003186_abnormal_redox_activity	0.54569178
80	MP0005499_abnormal_olfactory_system	0.53532423
81	MP0005394_taste/olfaction_phenotype	0.53532423
82	MP0002876_abnormal_thyroid_physiology	0.53165285
83	MP0009780_abnormal_chondrocyte_physiolo	0.52328371
84	MP0005409_darkened_coat_color	0.51739642
85	MP0008260_abnormal_autophagy	0.51008241
86	MP0009765_abnormal_xenobiotic_induced	0.50937728
87	MP0002089_abnormal_postnatal_growth/wei	0.50022535
88	MP0008469_abnormal_protein_level	0.48207627
89	MP0002970_abnormal_white_adipose	0.47528373
90	MP0005319_abnormal_enzyme/_coenzyme	0.47004677
91	MP0002060_abnormal_skin_morphology	0.44178890
92	MP0001845_abnormal_inflammatory_respons	0.43259083
93	MP0005375_adipose_tissue_phenotype	0.42593278
94	MP0009764_decreased_sensitivity_to	0.42014602
95	MP0003943_abnormal_hepatobiliary_system	0.40825582
96	MP0004043_abnormal_pH_regulation	0.40553611
97	MP0005334_abnormal_fat_pad	0.38634523
98	MP0000377_abnormal_hair_follicle	0.38579217
99	MP0004185_abnormal_adipocyte_glucose	0.38216629
100	MP0010678_abnormal_skin_adnexa	0.37325667
101	MP0003656_abnormal_erythrocyte_physiolo	0.36160127
102	MP0000750_abnormal_muscle_regeneration	0.35931080
103	MP0000367_abnormal_coat/_hair	0.35616616
104	MP0001502_abnormal_circadian_rhythm	0.34557197
105	MP0003795_abnormal_bone_structure	0.34552318
106	MP0003011_delayed_dark_adaptation	0.34385158
107	MP0000462_abnormal_digestive_system	0.34335301
108	MP0009642_abnormal_blood_homeostasis	0.34253078
109	MP0004858_abnormal_nervous_system	0.33810680
110	MP0003718_maternal_effect	0.33593043
111	MP0005379_endocrine/exocrine_gland_phen	0.33489612
112	* MP0001731_abnormal_postnatal_growth	0.33409439
113	MP0001485_abnormal_pinna_reflex	0.32849156
114	MP0005187_abnormal_penis_morphology	0.32737899
115	MP0000371_diluted_coat_color	0.32199953
116	MP0003436_decreased_susceptibility_to	0.31816511
117	MP0003329_amyloid_beta_deposits	0.31674494
118	MP0000537_abnormal_urethra_morphology	0.31526710
119	MP0005501_abnormal_skin_physiology	0.31026231
120	MP0005584_abnormal_enzyme/coenzyme_acti	0.30220441
121	MP0000858_altered_metastatic_potential	0.29738389
122	MP0002896_abnormal_bone_mineralization	0.29182347
123	MP0002069_abnormal_eating/drinking_beha	0.29166671
124	MP0008872_abnormal_physiological_respon	0.28823930
125	MP0004484_altered_response_of	0.28365333
126	MP0000647_abnormal_sebaceous_gland	0.27701946
127	MP0005636_abnormal_mineral_homeostasis	0.25523686
128	MP0001756_abnormal_urination	0.24992733
129	MP0000566_synostosis	0.24980160
130	MP0001849_ear_inflammation	0.24751607
131	MP0009333_abnormal_splenocyte_physiolog	0.23752598
132	MP0003453_abnormal_keratinocyte_physiol	0.23120160
133	MP0010155_abnormal_intestine_physiology	0.22761584
134	MP0000579_abnormal_nail_morphology	0.22564289
135	MP0008875_abnormal_xenobiotic_pharmacok	0.22179463
136	MP0001765_abnormal_ion_homeostasis	0.21890732

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Steatorrhea (HP:0002570)	8.43674076
2	Fat malabsorption (HP:0002630)	7.32474911
3	Abnormality of glutamine family amino acid metabolism (HP:0010902)	7.06535470
4	Gout (HP:0001997)	6.80014489
5	Hydroxyprolinuria (HP:0003080)	6.38845491
6	Abnormality of proline metabolism (HP:0010907)	6.38845491
7	Short chin (HP:0000331)	5.49591232
8	Decreased subcutaneous fat (HP:0001002)	5.32632191
9	Exocrine pancreatic insufficiency (HP:0001738)	5.19333124
10	Abnormality of subcutaneous fat tissue (HP:0001001)	4.86424646
11	Type I diabetes mellitus (HP:0100651)	4.77166435
12	Abnormal pancreas size (HP:0012094)	4.69282228
13	Tetraparesis (HP:0002273)	4.60235562
14	Ileus (HP:0002595)	4.59734214
15	Abnormality of the intrinsic pathway (HP:0010989)	4.39753264
16	Malnutrition (HP:0004395)	4.35394830
17	Hypoplasia of the pons (HP:0012110)	4.18209400
18	Maternal diabetes (HP:0009800)	4.13699451
19	Abnormality of the pons (HP:0007361)	3.90856743
20	Pancreatitis (HP:0001733)	3.82428499
21	Premature skin wrinkling (HP:0100678)	3.65434055
22	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.58138919
23	Ketosis (HP:0001946)	3.57686209
24	Ketoacidosis (HP:0001993)	3.53700935
25	Tubulointerstitial fibrosis (HP:0005576)	3.49319584
26	Tubulointerstitial nephritis (HP:0001970)	3.44606816
27	Cortical dysplasia (HP:0002539)	3.41652896
28	Carpal bone hypoplasia (HP:0001498)	3.38961716
29	Joint stiffness (HP:0001387)	3.28752224
30	Hypoproteinemia (HP:0003075)	3.28320661
31	Increased purine levels (HP:0004368)	3.22058577
32	Hyperuricemia (HP:0002149)	3.22058577
33	Abnormality of endocrine pancreas physiology (HP:0012093)	3.14646908
34	Abnormality of the pancreatic islet cells (HP:0006476)	3.14646908
35	Hyperglycinemia (HP:0002154)	3.08152056
36	Hypoglycemic coma (HP:0001325)	3.02048127
37	Abnormality of the pleura (HP:0002103)	3.00289495
38	Hyperglycinuria (HP:0003108)	2.98068255
39	Ventricular fibrillation (HP:0001663)	2.97546876
40	Long foot (HP:0001833)	2.94458952
41	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.90036260
42	Abnormal tarsal ossification (HP:0008369)	2.82412196
43	Abnormality of vitamin B metabolism (HP:0004340)	2.78810588
44	Right ventricular cardiomyopathy (HP:0011663)	2.76468469
45	Vascular calcification (HP:0004934)	2.74819335
46	Hypobetalipoproteinemia (HP:0003563)	2.72063913
47	Late onset (HP:0003584)	2.71259231
48	Abnormality of glycine metabolism (HP:0010895)	2.71051036
49	Abnormality of serine family amino acid metabolism (HP:0010894)	2.71051036
50	Abnormality of the common coagulation pathway (HP:0010990)	2.70647879
51	Hypoglycemic seizures (HP:0002173)	2.60670969
52	Villous atrophy (HP:0011473)	2.59807245
53	Abnormality of small intestinal villus morphology (HP:0011472)	2.59807245
54	Abnormal protein glycosylation (HP:0012346)	2.56215590
55	Abnormal glycosylation (HP:0012345)	2.56215590
56	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.56215590
57	Abnormal protein N-linked glycosylation (HP:0012347)	2.56215590
58	Abnormality of urine glucose concentration (HP:0011016)	2.53363678
59	Glycosuria (HP:0003076)	2.53363678
60	Rectal prolapse (HP:0002035)	2.50185185
61	Abnormality of vitamin metabolism (HP:0100508)	2.48111056
62	Fatigue (HP:0012378)	2.47624214
63	Abnormal biliary tract morphology (HP:0012440)	2.47458130
64	Progressive muscle weakness (HP:0003323)	2.45394870
65	Conjugated hyperbilirubinemia (HP:0002908)	2.42352699
66	Cardiovascular calcification (HP:0011915)	2.37725473
67	Prenatal maternal abnormality (HP:0002686)	2.35936123
68	Paraparesis (HP:0002385)	2.34050021
69	Hypoplasia of the uterus (HP:0000013)	2.33369817
70	Hyperinsulinemic hypoglycemia (HP:0000825)	2.32103786
71	Optic nerve hypoplasia (HP:0000609)	2.31811278
72	Megaloblastic anemia (HP:0001889)	2.31324607
73	Small epiphyses (HP:0010585)	2.29820426
74	Esophageal varix (HP:0002040)	2.29467171
75	Abnormality of purine metabolism (HP:0004352)	2.25470990
76	Acute hepatic failure (HP:0006554)	2.25196449
77	Proximal tubulopathy (HP:0000114)	2.24788775
78	Hypoplasia of the odontoid process (HP:0003311)	2.20352497
79	Vacuolated lymphocytes (HP:0001922)	2.19465728
80	Pectus carinatum (HP:0000768)	2.19129243
81	Male infertility (HP:0003251)	2.18717057
82	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.17306646
83	Chronic diarrhea (HP:0002028)	2.17000781
84	Abnormal number of erythroid precursors (HP:0012131)	2.16232711
85	Congenital glaucoma (HP:0001087)	2.15792529
86	Congenital malformation of the right heart (HP:0011723)	2.15565982
87	Double outlet right ventricle (HP:0001719)	2.15565982
88	Widely patent fontanelles and sutures (HP:0004492)	2.12980020
89	Abnormality of the renal cortex (HP:0011035)	2.12964763
90	Abnormality of cells of the erythroid lineage (HP:0012130)	2.12043968
91	Xanthomatosis (HP:0000991)	2.11099411
92	Hyperglycemia (HP:0003074)	2.10190894
93	Hyperphosphatemia (HP:0002905)	2.09756355
94	Barrel-shaped chest (HP:0001552)	2.08886782
95	Prolonged QT interval (HP:0001657)	2.08617795
96	Sex reversal (HP:0012245)	2.07115856
97	Abnormal sex determination (HP:0012244)	2.07115856
98	Abnormal foot bone ossification (HP:0010675)	2.06524902
99	Reduced antithrombin III activity (HP:0001976)	2.06253262
100	Ankyloglossia (HP:0010296)	2.04400714
101	Dysostosis multiplex (HP:0000943)	2.04253636
102	Tubular atrophy (HP:0000092)	2.02695419
103	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.02179195
104	Systemic lupus erythematosus (HP:0002725)	2.01107843
105	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.00917507
106	Pigmentary retinal degeneration (HP:0001146)	2.00162850
107	Myocardial infarction (HP:0001658)	2.00086558
108	Congenital sensorineural hearing impairment (HP:0008527)	1.99847628
109	Methylmalonic aciduria (HP:0012120)	1.98031550
110	Type I transferrin isoform profile (HP:0003642)	1.95760855
111	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.95117748
112	Abnormality of methionine metabolism (HP:0010901)	1.94653304
113	Anal atresia (HP:0002023)	1.93831917
114	Tubulointerstitial abnormality (HP:0001969)	1.93516471
115	Cortical visual impairment (HP:0100704)	1.92628446
116	Flat acetabular roof (HP:0003180)	1.89139978
117	Homocystinuria (HP:0002156)	1.89064127
118	Abnormality of homocysteine metabolism (HP:0010919)	1.89064127
119	Severe short stature (HP:0003510)	1.86142580
120	Vertebral compression fractures (HP:0002953)	1.85577776
121	Popliteal pterygium (HP:0009756)	1.83437431
122	Syncope (HP:0001279)	1.83275861
123	Lower limb hyperreflexia (HP:0002395)	1.82937307
124	Flattened epiphyses (HP:0003071)	1.82842785
125	Symptomatic seizures (HP:0011145)	1.82453007
126	Intrahepatic cholestasis (HP:0001406)	1.81781695
127	Renal salt wasting (HP:0000127)	1.81702460
128	Opisthotonus (HP:0002179)	1.81071382
129	Type II lissencephaly (HP:0007260)	1.80241703
130	Abdominal distention (HP:0003270)	1.80087798
131	Potter facies (HP:0002009)	1.79448304
132	Facial shape deformation (HP:0011334)	1.79448304
133	Acanthocytosis (HP:0001927)	1.78402738
134	Nausea (HP:0002018)	1.77951893
135	Progressive sensorineural hearing impairment (HP:0000408)	1.77824757
136	Limb hypertonia (HP:0002509)	1.77583821
137	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.77352818
138	Hyperammonemia (HP:0001987)	1.76547343
139	Glomerulosclerosis (HP:0000096)	1.76494857
140	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.76403743
141	Atrophic scars (HP:0001075)	1.75824357
142	Abnormality of alkaline phosphatase activity (HP:0004379)	1.73586971
143	Dehydration (HP:0001944)	1.69868166
144	Abnormal enzyme/coenzyme activity (HP:0012379)	1.68893114
145	Nephrolithiasis (HP:0000787)	1.68349205
146	Insulin-resistant diabetes mellitus (HP:0000831)	1.66653577
147	Confusion (HP:0001289)	1.66177027
148	Wide cranial sutures (HP:0010537)	1.63963040
149	Large for gestational age (HP:0001520)	1.63088954
150	Subcapsular cataract (HP:0000523)	1.62339763
151	Metabolic acidosis (HP:0001942)	1.62274751
152	Abdominal pain (HP:0002027)	1.62065757
153	Renal tubular acidosis (HP:0001947)	1.61751738
154	Glomerulonephritis (HP:0000099)	1.57953525
155	Gastrointestinal dysmotility (HP:0002579)	1.57720432
156	Decreased circulating renin level (HP:0003351)	1.57382784
157	Increased CSF protein (HP:0002922)	1.56858774
158	Elevated alkaline phosphatase (HP:0003155)	1.56447896
159	Hypercalciuria (HP:0002150)	1.51439464
160	Hypophosphatemia (HP:0002148)	1.47108339
161	Abnormality of chloride homeostasis (HP:0011422)	1.46690127
162	Hypolipoproteinemia (HP:0010981)	1.46096257
163	Abnormality of fatty-acid metabolism (HP:0004359)	1.45859099

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	9.40604721
2	ERN1	5.23489687
3	EIF2AK3	4.63139473
4	MAP2K2	4.29313630
5	ACVR1B	3.39959942
6	TRIB3	3.17142157
7	FRK	2.99830029
8	PKN2	2.80327371
9	PRKG2	2.67530672
10	INSRR	2.64326268
11	MAP3K12	2.15196202
12	MAPKAPK3	2.01968325
13	TAOK3	1.92490996
14	IRAK3	1.90293675
15	ZAP70	1.88108503
16	NME1	1.82872825
17	MAPK15	1.76502963
18	MAP2K1	1.73787251
19	GRK1	1.67900101
20	EIF2AK1	1.63379806
21	PAK2	1.53828042
22	SCYL2	1.51412707
23	WNK4	1.35537810
24	NME2	1.34450858
25	PTK6	1.29391378
26	CDK19	1.24911501
27	RPS6KB2	1.22936117
28	DYRK1A	1.15606000
29	MAP3K2	1.13181036
30	NLK	1.11590522
31	PDGFRB	1.10251439
32	EEF2K	1.05466660
33	TESK1	1.05188274
34	PIK3CG	1.03054939
35	PIK3CA	1.02619551
36	ERBB4	0.98744938
37	LATS1	0.97186275
38	PDK2	0.94570501
39	FLT3	0.94311862
40	MST1R	0.93764996
41	OXSR1	0.93336820
42	EPHA2	0.91147674
43	NTRK3	0.83857457
44	CAMKK1	0.81522118
45	MAP2K6	0.81012413
46	PRKCI	0.78466969
47	SIK1	0.77400155
48	MYLK	0.76756596
49	TAOK1	0.72322513
50	BMPR1B	0.69068030
51	DYRK1B	0.67685303
52	MTOR	0.67625029
53	STK39	0.64587931
54	IRAK2	0.64236843
55	RIPK1	0.63861023
56	STK24	0.60000112
57	CAMKK2	0.59316150
58	LMTK2	0.58510734
59	STK16	0.58246909
60	FER	0.57446011
61	FGFR3	0.57308768
62	LRRK2	0.57079824
63	DAPK2	0.57071860
64	PDPK1	0.54460567
65	TAOK2	0.53815999
66	RET	0.52885246
67	MET	0.51589375
68	MAP3K5	0.51051400
69	KSR2	0.49439899
70	MAP3K11	0.49138202
71	PRKCZ	0.46934679
72	EPHB1	0.46215528
73	MAP3K10	0.45786869
74	MAP3K1	0.45452718
75	RPS6KB1	0.45338675
76	TSSK6	0.43041599
77	MAP3K9	0.42766932
78	JAK1	0.41585403
79	PINK1	0.41377684
80	DAPK1	0.40742948
81	IRAK4	0.40638752
82	PRKCE	0.40367446
83	PTK2	0.39642101
84	TRPM7	0.39346540
85	PDK1	0.39127723
86	PDK3	0.39100259
87	PDK4	0.39100259
88	BCR	0.35255221
89	FGFR4	0.35250272
90	MAP3K3	0.34235506
91	PRKCA	0.33974935
92	PRKCH	0.33035534
93	ERBB3	0.32778276
94	PRKACG	0.32537061
95	NTRK1	0.31873274
96	MAP3K7	0.31136137
97	MAPK12	0.30691015
98	MAP3K14	0.30085440
99	ROCK1	0.29305872
100	MAPK3	0.28947239
101	PRKACB	0.28166086
102	NEK6	0.27975323
103	IRAK1	0.27889048
104	RPS6KA1	0.27051101
105	DDR2	0.26973263
106	MAPK7	0.26643527
107	PRKD3	0.26393475
108	MAP3K8	0.25159935
109	EPHA3	0.24959882
110	PDGFRA	0.24875042
111	NUAK1	0.24819820
112	JAK2	0.24409830
113	PRKAA2	0.24245507
114	MELK	0.22235394
115	TIE1	0.21937361
116	GRK6	0.21489988
117	ABL1	0.20905279
118	TBK1	0.20893066
119	NEK1	0.20516626
120	PRKD1	0.20338415
121	BMPR2	0.20058947
122	YES1	0.18138704
123	ILK	0.16996089
124	PIM1	0.16094201
125	STK38	0.15782528
126	CAMK4	0.14583394
127	CSNK1E	0.14464040
128	IGF1R	0.13983693
129	DAPK3	0.13913916
130	MAPK1	0.13905504
131	IKBKE	0.13528038
132	TYK2	0.13347088
133	CSNK1A1	0.13308524
134	PRKACA	0.13220839
135	CAMK2G	0.13053528
136	GSK3A	0.12441271
137	AKT3	0.12364161
138	PIM2	0.12025566
139	MAPK11	0.11684617
140	SRC	0.11244029
141	MATK	0.11206656
142	PRKAA1	0.11047907
143	PAK4	0.10836779
144	ERBB2	0.10691624
145	PRKCD	0.10287988
146	DYRK2	0.09467545
147	HIPK2	0.09020798
148	MST4	0.08147165
149	PASK	0.07668186
150	EGFR	0.07419402
151	CAMK1D	0.07188254

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	* Pancreatic secretion_Homo sapiens_hsa04972	8.04891133
2	Protein digestion and absorption_Homo sapiens_hsa04974	5.75351229
3	* Fat digestion and absorption_Homo sapiens_hsa04975	5.48583959
4	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.50080225
5	Protein export_Homo sapiens_hsa03060	3.28618520
6	Folate biosynthesis_Homo sapiens_hsa00790	3.09762804
7	Vitamin digestion and absorption_Homo sapiens_hsa04977	2.64727614
8	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.61352230
9	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.36620520
10	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	2.27803411
11	* Glycerolipid metabolism_Homo sapiens_hsa00561	2.13490057
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.12486506
13	Renin-angiotensin system_Homo sapiens_hsa04614	1.94502200
14	Steroid biosynthesis_Homo sapiens_hsa00100	1.88803349
15	Propanoate metabolism_Homo sapiens_hsa00640	1.72151192
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.50003833
17	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.44425043
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.43716356
19	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.18768273
20	Arginine and proline metabolism_Homo sapiens_hsa00330	1.16200540
21	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.14868888
22	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.10117450
23	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.10101390
24	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.00879817
25	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.96341417
26	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.95629627
27	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.94273316
28	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.89511483
29	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.86432561
30	Other glycan degradation_Homo sapiens_hsa00511	0.84217705
31	Sulfur metabolism_Homo sapiens_hsa00920	0.82875169
32	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.78374063
33	Selenocompound metabolism_Homo sapiens_hsa00450	0.78155084
34	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.75342797
35	Influenza A_Homo sapiens_hsa05164	0.73260202
36	Retinol metabolism_Homo sapiens_hsa00830	0.73220027
37	Insulin secretion_Homo sapiens_hsa04911	0.71407583
38	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.69922766
39	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.69536582
40	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.69277809
41	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.68142104
42	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.63262103
43	Vibrio cholerae infection_Homo sapiens_hsa05110	0.63156977
44	beta-Alanine metabolism_Homo sapiens_hsa00410	0.62356664
45	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.61339601
46	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.59766909
47	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.59542963
48	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.57924359
49	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.57848284
50	One carbon pool by folate_Homo sapiens_hsa00670	0.57792947
51	Notch signaling pathway_Homo sapiens_hsa04330	0.57688002
52	Glutathione metabolism_Homo sapiens_hsa00480	0.56562025
53	Fatty acid degradation_Homo sapiens_hsa00071	0.55212421
54	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.55194766
55	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.52367983
56	Caffeine metabolism_Homo sapiens_hsa00232	0.51279572
57	Pyruvate metabolism_Homo sapiens_hsa00620	0.51115133
58	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.49337104
59	Ether lipid metabolism_Homo sapiens_hsa00565	0.46296730
60	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.45913396
61	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.43269133
62	Tryptophan metabolism_Homo sapiens_hsa00380	0.40719516
63	Arginine biosynthesis_Homo sapiens_hsa00220	0.39612950
64	Legionellosis_Homo sapiens_hsa05134	0.38511518
65	Sphingolipid metabolism_Homo sapiens_hsa00600	0.38475800
66	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.36078811
67	PPAR signaling pathway_Homo sapiens_hsa03320	0.35073518
68	Carbon metabolism_Homo sapiens_hsa01200	0.34088103
69	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.33408350
70	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.33056984
71	Regulation of autophagy_Homo sapiens_hsa04140	0.32733329
72	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.30595969
73	* Metabolic pathways_Homo sapiens_hsa01100	0.29172672
74	Galactose metabolism_Homo sapiens_hsa00052	0.28882508
75	Gastric acid secretion_Homo sapiens_hsa04971	0.27441683
76	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.26202393
77	Lysosome_Homo sapiens_hsa04142	0.26136779
78	Endometrial cancer_Homo sapiens_hsa05213	0.26131390
79	Mineral absorption_Homo sapiens_hsa04978	0.25204235
80	Bile secretion_Homo sapiens_hsa04976	0.24252951
81	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.23435806
82	Sulfur relay system_Homo sapiens_hsa04122	0.21608438
83	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.20025502
84	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.19485412
85	Nitrogen metabolism_Homo sapiens_hsa00910	0.19141942
86	Histidine metabolism_Homo sapiens_hsa00340	0.18420920
87	Circadian rhythm_Homo sapiens_hsa04710	0.17773415
88	Alzheimers disease_Homo sapiens_hsa05010	0.17562137
89	Hepatitis C_Homo sapiens_hsa05160	0.17438866
90	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.17165929
91	VEGF signaling pathway_Homo sapiens_hsa04370	0.16832894
92	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.16500226
93	Pentose phosphate pathway_Homo sapiens_hsa00030	0.16387453
94	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.15111412
95	ABC transporters_Homo sapiens_hsa02010	0.14993064
96	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.14931961
97	Chemical carcinogenesis_Homo sapiens_hsa05204	0.13947569
98	Fatty acid metabolism_Homo sapiens_hsa01212	0.13002394
99	Parkinsons disease_Homo sapiens_hsa05012	0.10846722
100	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.10470540
101	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.08495410
102	Insulin resistance_Homo sapiens_hsa04931	0.08258770
103	Tyrosine metabolism_Homo sapiens_hsa00350	0.06594357
104	Phenylalanine metabolism_Homo sapiens_hsa00360	0.06216017
105	Calcium signaling pathway_Homo sapiens_hsa04020	0.06019895
106	Prostate cancer_Homo sapiens_hsa05215	0.06017887
107	mTOR signaling pathway_Homo sapiens_hsa04150	0.05859006
108	Tight junction_Homo sapiens_hsa04530	0.05429555
109	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.05210507
110	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.04001114
111	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.03875920
112	Peroxisome_Homo sapiens_hsa04146	0.03267603
113	Toxoplasmosis_Homo sapiens_hsa05145	0.03261285
114	Bladder cancer_Homo sapiens_hsa05219	0.03007791
115	Complement and coagulation cascades_Homo sapiens_hsa04610	0.01889021
116	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.01667055
117	Butanoate metabolism_Homo sapiens_hsa00650	0.00893727
118	Fatty acid elongation_Homo sapiens_hsa00062	-0.1114321
119	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	-0.1089181
120	TNF signaling pathway_Homo sapiens_hsa04668	-0.0917275
121	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	-0.0773354
122	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	-0.0703555
123	Asthma_Homo sapiens_hsa05310	-0.0598595
124	Intestinal immune network for IgA production_Homo sapiens_hsa04672	-0.0532934
125	Leukocyte transendothelial migration_Homo sapiens_hsa04670	-0.0372040
126	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	-0.0349706
127	Cocaine addiction_Homo sapiens_hsa05030	-0.0145558
128	Type I diabetes mellitus_Homo sapiens_hsa04940	-0.0051985
129	Oxidative phosphorylation_Homo sapiens_hsa00190	-0.0030292

PNLIPRP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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