PNMA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.88053379
2vocalization behavior (GO:0071625)5.61432662
3synaptic vesicle exocytosis (GO:0016079)5.43290359
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.33749882
5neuron cell-cell adhesion (GO:0007158)5.28015306
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.11427094
7synaptic vesicle maturation (GO:0016188)5.09153373
8protein localization to synapse (GO:0035418)5.08652616
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.05941477
10regulation of glutamate receptor signaling pathway (GO:1900449)5.04420409
11locomotory exploration behavior (GO:0035641)5.01279576
12glutamate secretion (GO:0014047)4.94634970
13regulation of synaptic vesicle exocytosis (GO:2000300)4.79665807
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.62609224
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.56417097
16exploration behavior (GO:0035640)4.48347538
17neurotransmitter secretion (GO:0007269)4.37248295
18sodium ion export (GO:0071436)4.35911265
19regulation of synaptic vesicle transport (GO:1902803)4.25123868
20glutamate receptor signaling pathway (GO:0007215)4.24416571
21neuronal action potential propagation (GO:0019227)4.23025725
22synaptic vesicle docking involved in exocytosis (GO:0016081)4.17396968
23layer formation in cerebral cortex (GO:0021819)4.09777426
24regulation of long-term neuronal synaptic plasticity (GO:0048169)4.08976916
25neuron recognition (GO:0008038)4.08883336
26neuron-neuron synaptic transmission (GO:0007270)4.07918227
27synaptic transmission, glutamatergic (GO:0035249)4.02038398
28regulation of neuronal synaptic plasticity (GO:0048168)4.00247412
29pyrimidine nucleobase catabolic process (GO:0006208)3.89622393
30proline transport (GO:0015824)3.89400303
31gamma-aminobutyric acid signaling pathway (GO:0007214)3.80787074
32dendritic spine morphogenesis (GO:0060997)3.79954657
33neurotransmitter-gated ion channel clustering (GO:0072578)3.79944495
34regulation of synapse structural plasticity (GO:0051823)3.74867776
35regulation of excitatory postsynaptic membrane potential (GO:0060079)3.72360943
36neurotransmitter transport (GO:0006836)3.64888430
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.63718158
38transmission of nerve impulse (GO:0019226)3.63068880
39axonal fasciculation (GO:0007413)3.60767723
40presynaptic membrane assembly (GO:0097105)3.60044345
41regulation of postsynaptic membrane potential (GO:0060078)3.58759804
42cerebellar granule cell differentiation (GO:0021707)3.58583251
43postsynaptic membrane organization (GO:0001941)3.56933038
44cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.56104904
45long-term memory (GO:0007616)3.55718273
46startle response (GO:0001964)3.55717508
47positive regulation of synapse maturation (GO:0090129)3.54684826
48positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.54507072
49gamma-aminobutyric acid transport (GO:0015812)3.53366422
50L-amino acid import (GO:0043092)3.52700744
51negative regulation of synaptic transmission, GABAergic (GO:0032229)3.52647833
52response to histamine (GO:0034776)3.52415663
53membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.52259500
54positive regulation of synaptic transmission, GABAergic (GO:0032230)3.46953573
55positive regulation of membrane potential (GO:0045838)3.46727279
56nucleobase catabolic process (GO:0046113)3.45271215
57regulation of dendritic spine morphogenesis (GO:0061001)3.43890132
58regulation of synaptic transmission, glutamatergic (GO:0051966)3.43041751
59establishment of mitochondrion localization (GO:0051654)3.42764256
60neuronal ion channel clustering (GO:0045161)3.40415277
61regulation of neurotransmitter levels (GO:0001505)3.39810344
62cell migration in hindbrain (GO:0021535)3.39246596
63regulation of vesicle fusion (GO:0031338)3.38961082
64synaptic vesicle endocytosis (GO:0048488)3.38093961
65presynaptic membrane organization (GO:0097090)3.35376341
66regulation of synaptic plasticity (GO:0048167)3.34034317
67activation of protein kinase A activity (GO:0034199)3.33251102
68amino acid import (GO:0043090)3.33074135
69long-term synaptic potentiation (GO:0060291)3.29314247
70regulation of neurotransmitter secretion (GO:0046928)3.28980068
71potassium ion homeostasis (GO:0055075)3.28978804
72regulation of glutamate secretion (GO:0014048)3.28876614
73regulation of voltage-gated calcium channel activity (GO:1901385)3.28263453
74negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.25499409
75potassium ion import (GO:0010107)3.22865606
76behavioral fear response (GO:0001662)3.21672017
77behavioral defense response (GO:0002209)3.21672017
78central nervous system myelination (GO:0022010)3.21504545
79axon ensheathment in central nervous system (GO:0032291)3.21504545
80synapse assembly (GO:0007416)3.21395482
81innervation (GO:0060384)3.21258640
82detection of calcium ion (GO:0005513)3.20397930
83mechanosensory behavior (GO:0007638)3.19100869
84positive regulation of synapse assembly (GO:0051965)3.18071423
85cell communication by electrical coupling (GO:0010644)3.18028135
86neuromuscular synaptic transmission (GO:0007274)3.17952423
87G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.17398361
88cellular sodium ion homeostasis (GO:0006883)3.16291017
89membrane depolarization (GO:0051899)3.14375763
90positive regulation of neurotransmitter transport (GO:0051590)3.13669102
91positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.11676843
92fear response (GO:0042596)3.11496620
93negative regulation of microtubule polymerization (GO:0031115)3.11362750
94positive regulation of dendritic spine morphogenesis (GO:0061003)3.10825612
95intraspecies interaction between organisms (GO:0051703)3.10781263
96social behavior (GO:0035176)3.10781263
97learning (GO:0007612)3.10710077
98membrane depolarization during action potential (GO:0086010)3.10456133
99auditory behavior (GO:0031223)3.09498953
100negative regulation of dendrite morphogenesis (GO:0050774)3.07871917
101G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.07710670
102regulation of neurotransmitter transport (GO:0051588)3.07293648
103mating behavior (GO:0007617)3.06811425
104synaptic transmission (GO:0007268)3.05411575
105cerebellar Purkinje cell differentiation (GO:0021702)3.04419035
106regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.03637224
107neurotransmitter uptake (GO:0001504)3.03498691
108positive regulation of neurotransmitter secretion (GO:0001956)3.02369096
109behavioral response to cocaine (GO:0048148)3.02252102
110response to auditory stimulus (GO:0010996)3.01944254
111vesicle transport along microtubule (GO:0047496)3.01924114
112cellular potassium ion homeostasis (GO:0030007)3.00284342
113negative regulation of dendrite development (GO:2000171)2.99875834
114membrane hyperpolarization (GO:0060081)2.99126915
115regulation of dendritic spine development (GO:0060998)2.98245564
116serotonin metabolic process (GO:0042428)2.97308681
117neuromuscular process controlling balance (GO:0050885)2.97059072
118synaptic vesicle transport (GO:0048489)2.96973435
119establishment of synaptic vesicle localization (GO:0097480)2.96973435
120neuromuscular process controlling posture (GO:0050884)2.96855557
121positive regulation of dendritic spine development (GO:0060999)2.96617410
122dendrite morphogenesis (GO:0048813)2.95506788
123regulation of synapse maturation (GO:0090128)2.94277497
124regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.94273075
125regulation of synaptic transmission, GABAergic (GO:0032228)2.94010484
126dendritic spine organization (GO:0097061)2.91955204

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.33421697
2GBX2_23144817_ChIP-Seq_PC3_Human4.02692971
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.19651798
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.12488774
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01911061
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.84222354
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62296372
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61906803
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61906803
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61426012
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.56397571
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50887503
13TAF15_26573619_Chip-Seq_HEK293_Human2.49470064
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45604068
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.43466053
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.39121514
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.38535833
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.38425629
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.29876298
20* REST_18959480_ChIP-ChIP_MESCs_Mouse2.28550790
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.27254889
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.20489534
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12479016
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.12341794
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.08981175
26CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08720582
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.08034714
28RNF2_27304074_Chip-Seq_ESCs_Mouse2.06197615
29DROSHA_22980978_ChIP-Seq_HELA_Human2.05134340
30AR_21572438_ChIP-Seq_LNCaP_Human1.94875632
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86207901
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.84297733
33SMAD4_21799915_ChIP-Seq_A2780_Human1.79222272
34ZNF274_21170338_ChIP-Seq_K562_Hela1.71556747
35P300_19829295_ChIP-Seq_ESCs_Human1.70527842
36* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.68937611
37IGF1R_20145208_ChIP-Seq_DFB_Human1.68724352
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67756633
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55818586
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.53123311
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50141983
42FUS_26573619_Chip-Seq_HEK293_Human1.46708437
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.46488488
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45099430
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.44761383
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44717401
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.44576356
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44293869
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43678727
50RNF2_27304074_Chip-Seq_NSC_Mouse1.40809879
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39755471
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37341000
53* SOX2_21211035_ChIP-Seq_LN229_Gbm1.36408659
54VDR_22108803_ChIP-Seq_LS180_Human1.36365652
55* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35676504
56AR_25329375_ChIP-Seq_VCAP_Human1.34924647
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34719747
58ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.31525092
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30960630
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30885484
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.30328052
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25199095
63RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23974982
64STAT3_23295773_ChIP-Seq_U87_Human1.23774381
65* RING1B_27294783_Chip-Seq_ESCs_Mouse1.23192850
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18584365
67* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17150818
68JUN_21703547_ChIP-Seq_K562_Human1.15880506
69AR_19668381_ChIP-Seq_PC3_Human1.14264539
70TCF4_23295773_ChIP-Seq_U87_Human1.12442863
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.10272011
72FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08915070
73P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07965301
74PRDM14_20953172_ChIP-Seq_ESCs_Human1.07444860
75MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06361747
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06332644
77* RUNX2_22187159_ChIP-Seq_PCA_Human1.06268374
78ER_23166858_ChIP-Seq_MCF-7_Human1.04824576
79LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03934921
80* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03755929
81KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02256051
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02151724
83RING1B_27294783_Chip-Seq_NPCs_Mouse1.01982468
84YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01710259
85ARNT_22903824_ChIP-Seq_MCF-7_Human0.99558582
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96533351
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96533351
88BCAT_22108803_ChIP-Seq_LS180_Human0.96119369
89CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96045065
90DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95824997
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95569077
92NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93542765
93RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93541384
94SMAD3_21741376_ChIP-Seq_ESCs_Human0.93076187
95AHR_22903824_ChIP-Seq_MCF-7_Human0.92937577
96NANOG_18555785_Chip-Seq_ESCs_Mouse0.92421547
97* KDM2B_26808549_Chip-Seq_REH_Human0.92224063
98WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91852136
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91823733
100OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91606697
101FLI1_21867929_ChIP-Seq_TH2_Mouse0.91018873
102GATA1_26923725_Chip-Seq_HPCs_Mouse0.90913462
103CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90898342
104STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89990262
105* CBP_20019798_ChIP-Seq_JUKART_Human0.89900941
106* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89900941
107SOX9_26525672_Chip-Seq_HEART_Mouse0.89018172
108TP53_18474530_ChIP-ChIP_U2OS_Human0.87768129
109ZFP281_18757296_ChIP-ChIP_E14_Mouse0.86848585
110ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86798523
111SMAD4_21741376_ChIP-Seq_HESCs_Human0.85561856
112TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.85421030
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84595066
114* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83672272

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.81018897
2MP0003880_abnormal_central_pattern5.01347295
3MP0003635_abnormal_synaptic_transmissio3.97517686
4MP0004270_analgesia3.78150572
5MP0009745_abnormal_behavioral_response3.41471504
6MP0001968_abnormal_touch/_nociception3.40923892
7MP0002063_abnormal_learning/memory/cond3.26849148
8MP0002064_seizures3.06526263
9MP0009046_muscle_twitch2.98911026
10MP0002735_abnormal_chemical_nociception2.92371303
11MP0002572_abnormal_emotion/affect_behav2.85216616
12MP0002734_abnormal_mechanical_nocicepti2.78608931
13MP0002736_abnormal_nociception_after2.72992759
14MP0002822_catalepsy2.69405958
15MP0006276_abnormal_autonomic_nervous2.63788175
16MP0005423_abnormal_somatic_nervous2.55600441
17MP0002272_abnormal_nervous_system2.52564820
18MP0001486_abnormal_startle_reflex2.43514688
19MP0001440_abnormal_grooming_behavior2.35404398
20MP0002733_abnormal_thermal_nociception2.34871837
21MP0001501_abnormal_sleep_pattern2.29677219
22MP0001529_abnormal_vocalization2.18372236
23MP0001970_abnormal_pain_threshold2.13932300
24MP0002067_abnormal_sensory_capabilities2.01472853
25MP0002184_abnormal_innervation2.00162956
26MP0000778_abnormal_nervous_system1.94144714
27MP0004924_abnormal_behavior1.86816592
28MP0005386_behavior/neurological_phenoty1.86816592
29MP0002557_abnormal_social/conspecific_i1.81611355
30MP0003122_maternal_imprinting1.73683253
31MP0004858_abnormal_nervous_system1.71042646
32MP0001905_abnormal_dopamine_level1.68722856
33MP0004811_abnormal_neuron_physiology1.68620352
34MP0001984_abnormal_olfaction1.62646240
35MP0003329_amyloid_beta_deposits1.61133921
36MP0005646_abnormal_pituitary_gland1.60264564
37MP0003787_abnormal_imprinting1.54781602
38MP0005645_abnormal_hypothalamus_physiol1.53042592
39MP0000955_abnormal_spinal_cord1.52992141
40MP0002909_abnormal_adrenal_gland1.50049745
41MP0008569_lethality_at_weaning1.48793396
42MP0009780_abnormal_chondrocyte_physiolo1.45980061
43MP0001188_hyperpigmentation1.44783492
44MP0002882_abnormal_neuron_morphology1.41135282
45MP0002066_abnormal_motor_capabilities/c1.40536499
46MP0003879_abnormal_hair_cell1.38460656
47MP0004142_abnormal_muscle_tone1.33915765
48MP0001502_abnormal_circadian_rhythm1.19801846
49MP0003690_abnormal_glial_cell1.12835196
50MP0002152_abnormal_brain_morphology1.12624495
51MP0000751_myopathy1.12302681
52MP0002837_dystrophic_cardiac_calcinosis1.09547258
53MP0008872_abnormal_physiological_respon1.07623475
54MP0002638_abnormal_pupillary_reflex1.07258228
55MP0003633_abnormal_nervous_system1.04061118
56MP0004885_abnormal_endolymph1.02178882
57MP0010386_abnormal_urinary_bladder1.01388029
58MP0000920_abnormal_myelination1.00949225
59MP0002876_abnormal_thyroid_physiology0.99737051
60MP0002102_abnormal_ear_morphology0.97466791
61MP0001986_abnormal_taste_sensitivity0.96819928
62MP0003631_nervous_system_phenotype0.95508244
63MP0002229_neurodegeneration0.92843797
64MP0002069_abnormal_eating/drinking_beha0.92434617
65MP0005499_abnormal_olfactory_system0.92347854
66MP0005394_taste/olfaction_phenotype0.92347854
67MP0004145_abnormal_muscle_electrophysio0.91272183
68MP0000631_abnormal_neuroendocrine_gland0.88843928
69MP0004147_increased_porphyrin_level0.88056132
70MP0001963_abnormal_hearing_physiology0.87494578
71MP0002752_abnormal_somatic_nervous0.85984001
72MP0004742_abnormal_vestibular_system0.85813179
73MP0004085_abnormal_heartbeat0.85558883
74MP0005623_abnormal_meninges_morphology0.85024779
75MP0002653_abnormal_ependyma_morphology0.82442636
76MP0003123_paternal_imprinting0.82281098
77MP0008874_decreased_physiological_sensi0.82159459
78MP0005535_abnormal_body_temperature0.81666902
79MP0003121_genomic_imprinting0.81630182
80MP0005551_abnormal_eye_electrophysiolog0.80123994
81MP0005253_abnormal_eye_physiology0.77575691
82MP0005409_darkened_coat_color0.75382057
83MP0003634_abnormal_glial_cell0.72008560
84MP0005187_abnormal_penis_morphology0.71924814
85MP0002751_abnormal_autonomic_nervous0.71105751
86MP0003632_abnormal_nervous_system0.69888431
87MP0001664_abnormal_digestion0.69262563
88MP0006072_abnormal_retinal_apoptosis0.67594795
89MP0002234_abnormal_pharynx_morphology0.67445354
90MP0004215_abnormal_myocardial_fiber0.65699358
91MP0003938_abnormal_ear_development0.65667442
92MP0001177_atelectasis0.64897102
93MP0003861_abnormal_nervous_system0.64860884
94MP0004133_heterotaxia0.64410928
95MP0000013_abnormal_adipose_tissue0.63142907
96MP0003137_abnormal_impulse_conducting0.62794112
97MP0000604_amyloidosis0.62766287
98MP0004484_altered_response_of0.61460982
99MP0001485_abnormal_pinna_reflex0.60743318
100MP0008877_abnormal_DNA_methylation0.59784129
101MP0003283_abnormal_digestive_organ0.59774111
102MP0001943_abnormal_respiration0.59378138
103MP0000026_abnormal_inner_ear0.59304585
104MP0005171_absent_coat_pigmentation0.59180586
105MP0010768_mortality/aging0.59139844
106MP0000569_abnormal_digit_pigmentation0.56657136
107MP0004233_abnormal_muscle_weight0.56132936
108MP0001346_abnormal_lacrimal_gland0.54707451
109MP0004043_abnormal_pH_regulation0.54418461
110MP0010770_preweaning_lethality0.53411312
111MP0002082_postnatal_lethality0.53411312
112MP0010769_abnormal_survival0.52551449
113MP0002090_abnormal_vision0.51896433
114MP0001348_abnormal_lacrimal_gland0.50696542
115MP0001299_abnormal_eye_distance/0.50655523
116MP0003956_abnormal_body_size0.50623480

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.80549479
2Myokymia (HP:0002411)6.53333904
3Focal seizures (HP:0007359)5.68536833
4Atonic seizures (HP:0010819)5.02037346
5Visual hallucinations (HP:0002367)4.97711423
6Epileptic encephalopathy (HP:0200134)4.77346383
7Febrile seizures (HP:0002373)4.52713885
8Absence seizures (HP:0002121)4.39204435
9Progressive cerebellar ataxia (HP:0002073)4.01583031
10Dialeptic seizures (HP:0011146)4.00744452
11Generalized tonic-clonic seizures (HP:0002069)3.83915062
12Hyperventilation (HP:0002883)3.58847827
13Limb dystonia (HP:0002451)3.48192555
14Broad-based gait (HP:0002136)3.47609894
15Amblyopia (HP:0000646)3.20303562
16Impaired vibration sensation in the lower limbs (HP:0002166)3.18150216
17Action tremor (HP:0002345)3.14281608
18Supranuclear gaze palsy (HP:0000605)3.09312272
19Progressive inability to walk (HP:0002505)3.04896895
20Poor eye contact (HP:0000817)2.99467664
21Ankle clonus (HP:0011448)2.95065611
22Pheochromocytoma (HP:0002666)2.92506733
23Abnormal eating behavior (HP:0100738)2.91706841
24Anxiety (HP:0000739)2.86307090
25Truncal ataxia (HP:0002078)2.85777664
26Gaze-evoked nystagmus (HP:0000640)2.81800328
27Insidious onset (HP:0003587)2.81013332
28Termporal pattern (HP:0011008)2.81013332
29Excessive salivation (HP:0003781)2.80102127
30Drooling (HP:0002307)2.80102127
31Mutism (HP:0002300)2.80032509
32Polyphagia (HP:0002591)2.79637160
33Dysdiadochokinesis (HP:0002075)2.79173619
34Depression (HP:0000716)2.77493245
35Urinary bladder sphincter dysfunction (HP:0002839)2.75848920
36Hemiplegia (HP:0002301)2.70620376
37Impaired social interactions (HP:0000735)2.64560424
38Abnormal social behavior (HP:0012433)2.64560424
39Neuroendocrine neoplasm (HP:0100634)2.64017929
40Urinary urgency (HP:0000012)2.62332358
41Abnormality of the corticospinal tract (HP:0002492)2.61647867
42Dysmetria (HP:0001310)2.60156009
43Inability to walk (HP:0002540)2.58394837
44Epileptiform EEG discharges (HP:0011182)2.55062786
45Gait imbalance (HP:0002141)2.53202991
46Cerebral inclusion bodies (HP:0100314)2.50400167
47Intention tremor (HP:0002080)2.47658580
48EEG with generalized epileptiform discharges (HP:0011198)2.43417154
49Papilledema (HP:0001085)2.42827913
50Diplopia (HP:0000651)2.41125748
51Abnormality of binocular vision (HP:0011514)2.41125748
52Absent speech (HP:0001344)2.41057207
53Sleep apnea (HP:0010535)2.40684033
54Spastic gait (HP:0002064)2.37581892
55Postural instability (HP:0002172)2.34309261
56Fetal akinesia sequence (HP:0001989)2.33833361
57Bradykinesia (HP:0002067)2.29666908
58Hypsarrhythmia (HP:0002521)2.28064501
59Hemiparesis (HP:0001269)2.27638651
60Amyotrophic lateral sclerosis (HP:0007354)2.27485409
61Torticollis (HP:0000473)2.24707163
62Neurofibrillary tangles (HP:0002185)2.24358777
63Abnormality of the lower motor neuron (HP:0002366)2.23901237
64Failure to thrive in infancy (HP:0001531)2.22156016
65Cerebral hypomyelination (HP:0006808)2.18282921
66Delusions (HP:0000746)2.17670278
67Morphological abnormality of the pyramidal tract (HP:0002062)2.17302192
68Focal dystonia (HP:0004373)2.16927399
69Scanning speech (HP:0002168)2.16421143
70Spastic tetraplegia (HP:0002510)2.15800630
71Split foot (HP:0001839)2.14595487
72Genetic anticipation (HP:0003743)2.13324914
73Hypoventilation (HP:0002791)2.11955369
74Impaired smooth pursuit (HP:0007772)2.10638103
75Protruding tongue (HP:0010808)2.10242675
76Spastic tetraparesis (HP:0001285)2.10228955
77Specific learning disability (HP:0001328)2.09115358
78Lower limb muscle weakness (HP:0007340)2.08022490
79Megalencephaly (HP:0001355)2.07526364
80Stereotypic behavior (HP:0000733)2.07068832
81Retinal dysplasia (HP:0007973)2.03278115
82Generalized myoclonic seizures (HP:0002123)2.01971598
83Impaired vibratory sensation (HP:0002495)2.01420579
84Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.01107756
85Degeneration of the lateral corticospinal tracts (HP:0002314)2.01107756
86Congenital primary aphakia (HP:0007707)2.00795770
87Agitation (HP:0000713)2.00440096
88Akinesia (HP:0002304)2.00378231
89Status epilepticus (HP:0002133)1.97806445
90Blue irides (HP:0000635)1.96922639
91Craniofacial dystonia (HP:0012179)1.96793799
92Hypoplasia of the brainstem (HP:0002365)1.94466734
93Aplasia/Hypoplasia of the brainstem (HP:0007362)1.94466734
94Acute necrotizing encephalopathy (HP:0006965)1.94242581
95Abnormal hair whorl (HP:0010721)1.92603380
96Medial flaring of the eyebrow (HP:0010747)1.92598160
97Abnormality of salivation (HP:0100755)1.92460684
98Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.92098248
99Poor suck (HP:0002033)1.91402201
100Neoplasm of the peripheral nervous system (HP:0100007)1.91227703
101Exotropia (HP:0000577)1.90349745
102Incomplete penetrance (HP:0003829)1.89120466
103Lissencephaly (HP:0001339)1.88670783
104Nephrogenic diabetes insipidus (HP:0009806)1.86686278
105Clonus (HP:0002169)1.86392612
106Psychosis (HP:0000709)1.85821406
107Abnormality of the labia minora (HP:0012880)1.85387683
108Progressive macrocephaly (HP:0004481)1.84885414
109Impaired pain sensation (HP:0007328)1.84066536
110Abnormality of pain sensation (HP:0010832)1.84066536
111Tetraplegia (HP:0002445)1.83581439
112Hypoplasia of the corpus callosum (HP:0002079)1.83482108
113Genital tract atresia (HP:0001827)1.81967543
114Type II lissencephaly (HP:0007260)1.81216257
115Hyperthyroidism (HP:0000836)1.80395617
116Gait ataxia (HP:0002066)1.80349356
117Muscular hypotonia of the trunk (HP:0008936)1.79398671
118Peripheral hypomyelination (HP:0007182)1.77312897
119Annular pancreas (HP:0001734)1.74474892
120Neuronal loss in central nervous system (HP:0002529)1.73357233
121Vaginal atresia (HP:0000148)1.72922605
122Abnormality of ocular smooth pursuit (HP:0000617)1.72249113

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.37246821
2EPHA43.67436409
3MARK13.64196074
4MAP3K93.62127436
5MAP3K43.46933938
6MAP2K72.95908725
7MINK12.86716727
8CASK2.76340846
9MAP3K122.74139369
10PNCK2.23710615
11MAP2K42.20008572
12NTRK22.12358123
13DAPK21.99626783
14KSR21.90601510
15PLK21.90385120
16NTRK11.90061852
17PINK11.85065775
18RIPK41.82646411
19PAK61.81051639
20KSR11.65828470
21MAPK131.65801761
22GRK51.63513869
23TNIK1.61794200
24MAP4K21.56515946
25DAPK11.54844247
26ARAF1.52455214
27CDK51.45258640
28CDK191.37375439
29LATS21.34614187
30FRK1.33484288
31PRKCG1.28854739
32PRPF4B1.22982567
33CAMKK11.21886471
34SIK21.17900258
35UHMK11.13149663
36PRKD31.10506076
37CAMK2A1.10035271
38PHKG11.09997484
39PHKG21.09997484
40FES1.00286054
41NME10.98039332
42CDK140.95708374
43CDK180.95559425
44MAP3K20.94825097
45CAMKK20.93976019
46FGFR20.93629926
47CAMK2B0.92189783
48CDK150.90880307
49PKN10.89553055
50TRIM280.85922902
51CSNK1G20.84083452
52PAK30.82077043
53STK380.81491192
54CDK11A0.79503585
55CSNK1A1L0.79096248
56PTK2B0.78141446
57OXSR10.77267924
58EPHA30.76891042
59MAP3K130.76866887
60BMPR20.76307987
61SGK4940.75412619
62SGK2230.75412619
63RAF10.75272161
64AKT30.75179372
65GRK70.73921059
66CCNB10.72471626
67RET0.69490604
68DYRK1A0.69086355
69CSNK1G10.67967494
70STK110.67474248
71TYRO30.67109215
72CAMK40.66549221
73BCR0.65894288
74WNK30.65562067
75SGK20.64407628
76SIK30.61621492
77TNK20.60662761
78PRKCE0.60441305
79CAMK10.60376365
80FGR0.58606124
81SGK10.57846427
82FER0.57122435
83DYRK20.55357773
84CAMK2D0.52807649
85LIMK10.51018790
86PRKCZ0.50675311
87LMTK20.49255080
88BRAF0.48867284
89MARK20.47548640
90CAMK2G0.47365414
91TSSK60.47216753
92MAP2K10.46827168
93BMPR1B0.46586885
94ADRBK10.46080062
95CAMK1G0.45889805
96ADRBK20.45811097
97CSNK1D0.44034589
98SCYL20.43994340
99INSRR0.43543569
100ALK0.43397929
101WNK40.42653717
102CSNK1G30.42642205
103NEK60.40792182
104RPS6KA30.39114710
105STK390.38856541
106MAPK100.38783455
107ERBB30.38775110
108PRKACA0.36522044
109PRKCH0.36130682
110CSNK1A10.35083883
111CSNK1E0.34843455
112SGK30.34806250
113TAOK10.34792343
114PRKG10.34503152
115MAP3K60.34467595
116DAPK30.34120406
117RPS6KA20.34069533
118PRKCB0.33137929
119MAP3K10.32663231
120ROCK20.32008274
121PRKCA0.31941692
122FYN0.31468328
123ERBB20.31362068
124PRKAA10.30632231
125CDK30.30495844
126BRSK10.28940242

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.17172378
2Synaptic vesicle cycle_Homo sapiens_hsa047213.55785415
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.84900063
4Long-term potentiation_Homo sapiens_hsa047202.77315940
5GABAergic synapse_Homo sapiens_hsa047272.73546713
6Olfactory transduction_Homo sapiens_hsa047402.67921812
7Amphetamine addiction_Homo sapiens_hsa050312.59490464
8Circadian entrainment_Homo sapiens_hsa047132.57600338
9Glutamatergic synapse_Homo sapiens_hsa047242.52380539
10Morphine addiction_Homo sapiens_hsa050322.49246684
11Dopaminergic synapse_Homo sapiens_hsa047282.34765907
12Collecting duct acid secretion_Homo sapiens_hsa049662.17352301
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.14363924
14Salivary secretion_Homo sapiens_hsa049702.05419573
15Taste transduction_Homo sapiens_hsa047422.01570655
16Serotonergic synapse_Homo sapiens_hsa047261.93556257
17Insulin secretion_Homo sapiens_hsa049111.86218415
18Cholinergic synapse_Homo sapiens_hsa047251.85912815
19Renin secretion_Homo sapiens_hsa049241.80942655
20Long-term depression_Homo sapiens_hsa047301.80308679
21Cocaine addiction_Homo sapiens_hsa050301.74340034
22Gastric acid secretion_Homo sapiens_hsa049711.71143017
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60446954
24Calcium signaling pathway_Homo sapiens_hsa040201.60001555
25Oxytocin signaling pathway_Homo sapiens_hsa049211.59218340
26Oxidative phosphorylation_Homo sapiens_hsa001901.58277897
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58265802
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.55577464
29Cardiac muscle contraction_Homo sapiens_hsa042601.44116996
30GnRH signaling pathway_Homo sapiens_hsa049121.42807999
31Gap junction_Homo sapiens_hsa045401.41604511
32Vibrio cholerae infection_Homo sapiens_hsa051101.35341110
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.31881704
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31381139
35Parkinsons disease_Homo sapiens_hsa050121.30171709
36Alzheimers disease_Homo sapiens_hsa050101.28351509
37Axon guidance_Homo sapiens_hsa043601.24832362
38Vitamin B6 metabolism_Homo sapiens_hsa007501.11997491
39Estrogen signaling pathway_Homo sapiens_hsa049151.09059172
40cAMP signaling pathway_Homo sapiens_hsa040241.06762797
41Melanogenesis_Homo sapiens_hsa049161.06580003
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05934524
43Oocyte meiosis_Homo sapiens_hsa041141.04263465
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02167550
45ErbB signaling pathway_Homo sapiens_hsa040120.99129876
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96899092
47Glioma_Homo sapiens_hsa052140.95602438
48Phototransduction_Homo sapiens_hsa047440.93345845
49Type II diabetes mellitus_Homo sapiens_hsa049300.92771761
50Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92663944
51Butanoate metabolism_Homo sapiens_hsa006500.91989397
52Huntingtons disease_Homo sapiens_hsa050160.91422259
53cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91186546
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86421581
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.85134866
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80252541
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76714377
58Dorso-ventral axis formation_Homo sapiens_hsa043200.73944323
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.70514911
60Bile secretion_Homo sapiens_hsa049760.68538866
61MAPK signaling pathway_Homo sapiens_hsa040100.67879158
62Alcoholism_Homo sapiens_hsa050340.65810052
63Thyroid hormone synthesis_Homo sapiens_hsa049180.65611752
64Pancreatic secretion_Homo sapiens_hsa049720.64236550
65Dilated cardiomyopathy_Homo sapiens_hsa054140.62538517
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.60714235
67Glucagon signaling pathway_Homo sapiens_hsa049220.59658614
68Choline metabolism in cancer_Homo sapiens_hsa052310.57157440
69Type I diabetes mellitus_Homo sapiens_hsa049400.53950918
70VEGF signaling pathway_Homo sapiens_hsa043700.53885115
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53195886
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53161491
73Ras signaling pathway_Homo sapiens_hsa040140.52588379
74Regulation of autophagy_Homo sapiens_hsa041400.52202140
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51615520
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.50449231
77Prion diseases_Homo sapiens_hsa050200.46978814
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46287584
79Hippo signaling pathway_Homo sapiens_hsa043900.46160555
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45952452
81Wnt signaling pathway_Homo sapiens_hsa043100.45558449
82Rap1 signaling pathway_Homo sapiens_hsa040150.44798842
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.43967534
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43416182
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42614402
86African trypanosomiasis_Homo sapiens_hsa051430.42552145
87beta-Alanine metabolism_Homo sapiens_hsa004100.42320589
88Hedgehog signaling pathway_Homo sapiens_hsa043400.41905033
89Fatty acid biosynthesis_Homo sapiens_hsa000610.40922738
90Ether lipid metabolism_Homo sapiens_hsa005650.39641504
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38678478
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37130053
93Renal cell carcinoma_Homo sapiens_hsa052110.36512775
94Rheumatoid arthritis_Homo sapiens_hsa053230.36213030
95Insulin signaling pathway_Homo sapiens_hsa049100.36106070
96Ovarian steroidogenesis_Homo sapiens_hsa049130.34966158
97Nitrogen metabolism_Homo sapiens_hsa009100.34870711
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34485082
99AMPK signaling pathway_Homo sapiens_hsa041520.34333988
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33780578
101Endometrial cancer_Homo sapiens_hsa052130.33595346
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32460866
103Protein export_Homo sapiens_hsa030600.32453735
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31691783
105Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31184874
106Inositol phosphate metabolism_Homo sapiens_hsa005620.30870339
107Steroid biosynthesis_Homo sapiens_hsa001000.29074726
108Endocytosis_Homo sapiens_hsa041440.28856580
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28694346
110mTOR signaling pathway_Homo sapiens_hsa041500.28293848
111Colorectal cancer_Homo sapiens_hsa052100.26764507
112Circadian rhythm_Homo sapiens_hsa047100.26362485
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26354282
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26210143
115Phagosome_Homo sapiens_hsa041450.26079420
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25751958
117Arginine and proline metabolism_Homo sapiens_hsa003300.25266111
118Melanoma_Homo sapiens_hsa052180.24863948
119Tight junction_Homo sapiens_hsa045300.24384583
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23487212
121Mineral absorption_Homo sapiens_hsa049780.22625277

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