PNMAL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.68955039
2synaptic vesicle exocytosis (GO:0016079)5.27995761
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.26992424
4vocalization behavior (GO:0071625)5.17174560
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.99113374
6synaptic vesicle maturation (GO:0016188)4.93672879
7neuron cell-cell adhesion (GO:0007158)4.89550801
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.89136782
9regulation of synaptic vesicle exocytosis (GO:2000300)4.80040969
10regulation of glutamate receptor signaling pathway (GO:1900449)4.72370521
11locomotory exploration behavior (GO:0035641)4.67541166
12protein localization to synapse (GO:0035418)4.63126005
13glutamate secretion (GO:0014047)4.58883150
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.43543710
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.34686583
16pyrimidine nucleobase catabolic process (GO:0006208)4.29314720
17regulation of synaptic vesicle transport (GO:1902803)4.27164464
18neurotransmitter secretion (GO:0007269)4.14213680
19neuronal action potential propagation (GO:0019227)4.14023509
20synaptic vesicle docking involved in exocytosis (GO:0016081)4.12315741
21glutamate receptor signaling pathway (GO:0007215)4.07984310
22regulation of neuronal synaptic plasticity (GO:0048168)3.96639907
23synaptic transmission, glutamatergic (GO:0035249)3.96043594
24exploration behavior (GO:0035640)3.95865872
25regulation of long-term neuronal synaptic plasticity (GO:0048169)3.90673257
26neuron recognition (GO:0008038)3.88150655
27neuron-neuron synaptic transmission (GO:0007270)3.84991190
28establishment of mitochondrion localization (GO:0051654)3.84290194
29dendritic spine morphogenesis (GO:0060997)3.82160071
30sodium ion export (GO:0071436)3.76877802
31gamma-aminobutyric acid signaling pathway (GO:0007214)3.73538549
32positive regulation of synaptic transmission, GABAergic (GO:0032230)3.70913997
33long-term memory (GO:0007616)3.68088390
34nucleobase catabolic process (GO:0046113)3.63694111
35layer formation in cerebral cortex (GO:0021819)3.63361566
36regulation of excitatory postsynaptic membrane potential (GO:0060079)3.59198050
37neurotransmitter-gated ion channel clustering (GO:0072578)3.57240967
38transmission of nerve impulse (GO:0019226)3.56851798
39regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.53858874
40regulation of synapse structural plasticity (GO:0051823)3.53341229
41neurotransmitter transport (GO:0006836)3.51629776
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.50922244
43regulation of postsynaptic membrane potential (GO:0060078)3.48640742
44proline transport (GO:0015824)3.47440723
45positive regulation of membrane potential (GO:0045838)3.46563039
46regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.45690350
47axonal fasciculation (GO:0007413)3.45120019
48activation of protein kinase A activity (GO:0034199)3.44446784
49presynaptic membrane assembly (GO:0097105)3.43907989
50postsynaptic membrane organization (GO:0001941)3.39689746
51response to histamine (GO:0034776)3.39417933
52detection of calcium ion (GO:0005513)3.37894372
53regulation of vesicle fusion (GO:0031338)3.37403390
54positive regulation of synapse maturation (GO:0090129)3.35536308
55long-term synaptic potentiation (GO:0060291)3.33222011
56regulation of synaptic plasticity (GO:0048167)3.30510150
57synaptic vesicle endocytosis (GO:0048488)3.29896296
58positive regulation of dendritic spine morphogenesis (GO:0061003)3.28550801
59gamma-aminobutyric acid transport (GO:0015812)3.27113249
60cell migration in hindbrain (GO:0021535)3.26609086
61cerebellar granule cell differentiation (GO:0021707)3.25148518
62negative regulation of synaptic transmission, GABAergic (GO:0032229)3.23654441
63regulation of glutamate secretion (GO:0014048)3.23441086
64regulation of neurotransmitter secretion (GO:0046928)3.23270693
65neuromuscular process controlling posture (GO:0050884)3.21806344
66regulation of synaptic transmission, glutamatergic (GO:0051966)3.21053165
67presynaptic membrane organization (GO:0097090)3.19233939
68regulation of neurotransmitter levels (GO:0001505)3.19142434
69potassium ion homeostasis (GO:0055075)3.18525212
70central nervous system myelination (GO:0022010)3.15652235
71axon ensheathment in central nervous system (GO:0032291)3.15652235
72mitochondrion transport along microtubule (GO:0047497)3.15484294
73establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.15484294
74cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.15097271
75regulation of dendritic spine morphogenesis (GO:0061001)3.13493517
76positive regulation of dendritic spine development (GO:0060999)3.12700918
77neuronal ion channel clustering (GO:0045161)3.12615324
78neuromuscular synaptic transmission (GO:0007274)3.11940407
79mating behavior (GO:0007617)3.10987466
80G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.10832175
81L-amino acid import (GO:0043092)3.08603600
82synapse assembly (GO:0007416)3.05360949
83innervation (GO:0060384)3.05265764
84positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.03826632
85regulation of voltage-gated calcium channel activity (GO:1901385)3.03787160
86behavioral defense response (GO:0002209)3.03198752
87behavioral fear response (GO:0001662)3.03198752
88membrane depolarization (GO:0051899)3.01961466
89potassium ion import (GO:0010107)3.01108588
90regulation of neurotransmitter transport (GO:0051588)3.00892236
91cell communication by electrical coupling (GO:0010644)3.00415031
92regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.00279335
93cellular potassium ion homeostasis (GO:0030007)2.99725101
94membrane hyperpolarization (GO:0060081)2.99400314
95regulation of calcium ion-dependent exocytosis (GO:0017158)2.97333823
96vesicle transport along microtubule (GO:0047496)2.97318926
97intraspecies interaction between organisms (GO:0051703)2.96044823
98social behavior (GO:0035176)2.96044823
99G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.95836961
100synaptic transmission (GO:0007268)2.95304488
101fear response (GO:0042596)2.94761583
102positive regulation of neurotransmitter transport (GO:0051590)2.94556671
103cerebellar Purkinje cell differentiation (GO:0021702)2.94369970
104startle response (GO:0001964)2.94081323
105negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.93483917
106membrane depolarization during action potential (GO:0086010)2.93107444
107learning (GO:0007612)2.93064646
108positive regulation of neurotransmitter secretion (GO:0001956)2.93004975
109auditory behavior (GO:0031223)2.92735923
110striatum development (GO:0021756)2.92045094
111dendrite morphogenesis (GO:0048813)2.91722713
112positive regulation of synapse assembly (GO:0051965)2.91621003
113positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.90610372
114response to auditory stimulus (GO:0010996)2.89974108
115cochlea development (GO:0090102)2.89241001
116regulation of synaptic transmission, GABAergic (GO:0032228)2.88522970
117mechanosensory behavior (GO:0007638)2.88408812
118cellular sodium ion homeostasis (GO:0006883)2.88057539
119positive regulation of synaptic transmission (GO:0050806)2.87257988
120dendritic spine organization (GO:0097061)2.87119535
121regulation of synaptic transmission (GO:0050804)2.87031421
122regulation of female receptivity (GO:0045924)2.85928767
123positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.85447257
124establishment of synaptic vesicle localization (GO:0097480)2.83498462
125synaptic vesicle transport (GO:0048489)2.83498462
126regulation of dendritic spine development (GO:0060998)2.80686863
127amino acid import (GO:0043090)2.79579473
128neurotransmitter uptake (GO:0001504)2.79201149

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.22532105
2GBX2_23144817_ChIP-Seq_PC3_Human3.71584095
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12123880
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.03644500
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00227187
6REST_21632747_ChIP-Seq_MESCs_Mouse2.85222304
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.61781457
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60759054
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.59838977
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.59838977
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.59791364
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50749165
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50558726
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50040115
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44712245
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.38944306
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.32707154
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.31860211
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.29744670
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.28814410
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.24467196
22DROSHA_22980978_ChIP-Seq_HELA_Human2.23575828
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.22505972
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.14097902
25TAF15_26573619_Chip-Seq_HEK293_Human2.12306730
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.04431444
27CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03622238
28IKZF1_21737484_ChIP-ChIP_HCT116_Human2.00919218
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95062684
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90731600
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72973107
32SMAD4_21799915_ChIP-Seq_A2780_Human1.71178071
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65499195
34AR_21572438_ChIP-Seq_LNCaP_Human1.60807434
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59957981
36ZNF274_21170338_ChIP-Seq_K562_Hela1.58345742
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56847433
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.55039575
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54530653
40P300_19829295_ChIP-Seq_ESCs_Human1.53886445
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45383425
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44744818
43IGF1R_20145208_ChIP-Seq_DFB_Human1.43207424
44EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40475708
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.38840063
46NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37772711
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.37464089
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37388610
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36201359
50RNF2_27304074_Chip-Seq_NSC_Mouse1.34555256
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32461901
52SOX2_21211035_ChIP-Seq_LN229_Gbm1.32323736
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29542836
54AR_25329375_ChIP-Seq_VCAP_Human1.28271559
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27558751
56GATA1_26923725_Chip-Seq_HPCs_Mouse1.26411445
57RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.24414683
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23952237
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.23843526
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.22260011
61FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.21715083
62TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19672569
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18565417
64* STAT3_23295773_ChIP-Seq_U87_Human1.18544164
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18191290
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15891383
67VDR_22108803_ChIP-Seq_LS180_Human1.13230268
68AR_19668381_ChIP-Seq_PC3_Human1.11386633
69FUS_26573619_Chip-Seq_HEK293_Human1.11074737
70TCF4_23295773_ChIP-Seq_U87_Human1.08318736
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07448227
72OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07244031
73RUNX2_22187159_ChIP-Seq_PCA_Human1.06665116
74MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06365199
75P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05808486
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04936409
77ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01557389
78DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01487151
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01251741
80SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00993746
81WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99229895
82SOX9_26525672_Chip-Seq_HEART_Mouse0.99203768
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98916771
84ER_23166858_ChIP-Seq_MCF-7_Human0.98227616
85KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98195067
86RING1B_27294783_Chip-Seq_NPCs_Mouse0.98030131
87YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97983591
88NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97775220
89CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97587799
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96614285
91SMAD3_21741376_ChIP-Seq_ESCs_Human0.96344637
92LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95453040
93ARNT_22903824_ChIP-Seq_MCF-7_Human0.94888398
94PRDM14_20953172_ChIP-Seq_ESCs_Human0.94486832
95SMAD_19615063_ChIP-ChIP_OVARY_Human0.93748862
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93697898
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93417049
98NANOG_18555785_Chip-Seq_ESCs_Mouse0.93329641
99JUN_21703547_ChIP-Seq_K562_Human0.93121519
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91798643
101CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91171637
102POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89748399
103CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.88533408
104ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88177437
105BCAT_22108803_ChIP-Seq_LS180_Human0.86457243
106STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.86152604
107CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85992709
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85602785
109AHR_22903824_ChIP-Seq_MCF-7_Human0.85031319
110KLF5_20875108_ChIP-Seq_MESCs_Mouse0.84702710
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84403307
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84403307
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84281845
114TP53_20018659_ChIP-ChIP_R1E_Mouse0.83702753
115RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83543719
116KDM2B_26808549_Chip-Seq_REH_Human0.83295373
117SMAD4_21741376_ChIP-Seq_HESCs_Human0.82673184

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.59708192
2MP0004859_abnormal_synaptic_plasticity5.36283768
3MP0003635_abnormal_synaptic_transmissio3.84239207
4MP0004270_analgesia3.29411089
5MP0009745_abnormal_behavioral_response3.22950420
6MP0002063_abnormal_learning/memory/cond3.11992944
7MP0002064_seizures2.98489616
8MP0005423_abnormal_somatic_nervous2.94060280
9MP0001968_abnormal_touch/_nociception2.86647775
10MP0002572_abnormal_emotion/affect_behav2.75844789
11MP0009046_muscle_twitch2.74527984
12MP0002272_abnormal_nervous_system2.49714091
13MP0009780_abnormal_chondrocyte_physiolo2.49630913
14MP0002822_catalepsy2.47046572
15MP0002734_abnormal_mechanical_nocicepti2.43330579
16MP0006276_abnormal_autonomic_nervous2.41816256
17MP0001486_abnormal_startle_reflex2.35774822
18MP0001501_abnormal_sleep_pattern2.26595855
19MP0002736_abnormal_nociception_after2.25883361
20MP0003122_maternal_imprinting2.24245512
21MP0005645_abnormal_hypothalamus_physiol2.22105649
22MP0001440_abnormal_grooming_behavior2.16788800
23MP0005646_abnormal_pituitary_gland2.03123764
24MP0001529_abnormal_vocalization2.00559845
25MP0002735_abnormal_chemical_nociception1.99641754
26MP0002733_abnormal_thermal_nociception1.92196504
27MP0001984_abnormal_olfaction1.90918864
28MP0002067_abnormal_sensory_capabilities1.90768426
29MP0001970_abnormal_pain_threshold1.86775898
30MP0002909_abnormal_adrenal_gland1.85390224
31MP0008877_abnormal_DNA_methylation1.84670295
32MP0002184_abnormal_innervation1.78530649
33MP0002557_abnormal_social/conspecific_i1.76288770
34MP0005386_behavior/neurological_phenoty1.75263219
35MP0004924_abnormal_behavior1.75263219
36MP0000778_abnormal_nervous_system1.73944225
37MP0003787_abnormal_imprinting1.65702837
38MP0000013_abnormal_adipose_tissue1.60558635
39MP0003329_amyloid_beta_deposits1.57486329
40MP0008569_lethality_at_weaning1.54723645
41MP0001502_abnormal_circadian_rhythm1.52700320
42MP0010386_abnormal_urinary_bladder1.51746567
43MP0004811_abnormal_neuron_physiology1.50806975
44MP0003879_abnormal_hair_cell1.46629724
45MP0000955_abnormal_spinal_cord1.45640564
46MP0001188_hyperpigmentation1.43772260
47MP0001905_abnormal_dopamine_level1.36628737
48MP0002882_abnormal_neuron_morphology1.35221500
49MP0002066_abnormal_motor_capabilities/c1.33513162
50MP0002837_dystrophic_cardiac_calcinosis1.33089401
51MP0004142_abnormal_muscle_tone1.29088230
52MP0003283_abnormal_digestive_organ1.26170844
53MP0002638_abnormal_pupillary_reflex1.22080942
54MP0004858_abnormal_nervous_system1.21749733
55MP0002653_abnormal_ependyma_morphology1.13818584
56MP0004885_abnormal_endolymph1.13198737
57MP0000566_synostosis1.12465841
58MP0000631_abnormal_neuroendocrine_gland1.12244934
59MP0003633_abnormal_nervous_system1.11465516
60MP0005551_abnormal_eye_electrophysiolog1.05551504
61MP0002152_abnormal_brain_morphology1.04787052
62MP0004742_abnormal_vestibular_system1.02016444
63MP0002069_abnormal_eating/drinking_beha0.99028337
64MP0002229_neurodegeneration0.97528552
65MP0006072_abnormal_retinal_apoptosis0.95371364
66MP0003861_abnormal_nervous_system0.95027709
67MP0005535_abnormal_body_temperature0.94973463
68MP0004043_abnormal_pH_regulation0.94654632
69MP0002876_abnormal_thyroid_physiology0.93989531
70MP0004147_increased_porphyrin_level0.93068448
71MP0004133_heterotaxia0.92339349
72MP0003631_nervous_system_phenotype0.91862365
73MP0000751_myopathy0.91667719
74MP0004145_abnormal_muscle_electrophysio0.91666882
75MP0005379_endocrine/exocrine_gland_phen0.88550115
76MP0008789_abnormal_olfactory_epithelium0.88185444
77MP0003938_abnormal_ear_development0.87251970
78MP0008872_abnormal_physiological_respon0.87165969
79MP0005499_abnormal_olfactory_system0.86158582
80MP0005394_taste/olfaction_phenotype0.86158582
81MP0003121_genomic_imprinting0.85030944
82MP0003183_abnormal_peptide_metabolism0.84257738
83MP0003119_abnormal_digestive_system0.84184637
84MP0001963_abnormal_hearing_physiology0.82389147
85MP0008961_abnormal_basal_metabolism0.79098290
86MP0003634_abnormal_glial_cell0.78430950
87MP0004085_abnormal_heartbeat0.77229678
88MP0002752_abnormal_somatic_nervous0.76525140
89MP0002102_abnormal_ear_morphology0.76518095
90MP0001986_abnormal_taste_sensitivity0.76312159
91MP0001664_abnormal_digestion0.72151915
92MP0005187_abnormal_penis_morphology0.70993117
93MP0001346_abnormal_lacrimal_gland0.69610996
94MP0000579_abnormal_nail_morphology0.69216775
95MP0000049_abnormal_middle_ear0.69131271
96MP0001485_abnormal_pinna_reflex0.67457695
97MP0003137_abnormal_impulse_conducting0.67064687
98MP0002090_abnormal_vision0.65926711
99MP0000920_abnormal_myelination0.65671654
100MP0002234_abnormal_pharynx_morphology0.65262570
101MP0008874_decreased_physiological_sensi0.65179342
102MP0006292_abnormal_olfactory_placode0.64315621
103MP0003123_paternal_imprinting0.63092742
104MP0005409_darkened_coat_color0.62804715
105MP0000026_abnormal_inner_ear0.61517160
106MP0010769_abnormal_survival0.61117972
107MP0001177_atelectasis0.61013021
108MP0002082_postnatal_lethality0.60444234
109MP0010770_preweaning_lethality0.60444234
110MP0001299_abnormal_eye_distance/0.59340919
111MP0002751_abnormal_autonomic_nervous0.58308136
112MP0001943_abnormal_respiration0.57783278
113MP0004233_abnormal_muscle_weight0.57644758
114MP0003632_abnormal_nervous_system0.56821489
115MP0000604_amyloidosis0.56816809
116MP0005253_abnormal_eye_physiology0.56334335
117MP0002693_abnormal_pancreas_physiology0.55651362
118MP0003690_abnormal_glial_cell0.55091589
119MP0004215_abnormal_myocardial_fiber0.53938171

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.22175180
2Myokymia (HP:0002411)5.87216362
3Focal seizures (HP:0007359)5.32876291
4Visual hallucinations (HP:0002367)5.23161033
5Atonic seizures (HP:0010819)4.72350242
6Epileptic encephalopathy (HP:0200134)4.58666407
7Absence seizures (HP:0002121)4.28341772
8Febrile seizures (HP:0002373)4.25155002
9Progressive cerebellar ataxia (HP:0002073)3.92478394
10Dialeptic seizures (HP:0011146)3.89936310
11Generalized tonic-clonic seizures (HP:0002069)3.78594936
12Hyperventilation (HP:0002883)3.28090991
13Anxiety (HP:0000739)3.16858062
14Broad-based gait (HP:0002136)3.16297090
15Supranuclear gaze palsy (HP:0000605)3.15744815
16Depression (HP:0000716)3.08483023
17Abnormal eating behavior (HP:0100738)3.07069037
18Poor eye contact (HP:0000817)3.01608170
19Amblyopia (HP:0000646)2.96456809
20Truncal ataxia (HP:0002078)2.95734149
21Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.93933645
22Polyphagia (HP:0002591)2.92808140
23Epileptiform EEG discharges (HP:0011182)2.85269204
24Action tremor (HP:0002345)2.83076762
25Drooling (HP:0002307)2.82877030
26Excessive salivation (HP:0003781)2.82877030
27Impaired vibration sensation in the lower limbs (HP:0002166)2.77691920
28Ankle clonus (HP:0011448)2.76744713
29EEG with generalized epileptiform discharges (HP:0011198)2.74312464
30Dysdiadochokinesis (HP:0002075)2.71972080
31Limb dystonia (HP:0002451)2.70428055
32Progressive inability to walk (HP:0002505)2.68177926
33Dysmetria (HP:0001310)2.68139689
34Abnormal social behavior (HP:0012433)2.67640919
35Impaired social interactions (HP:0000735)2.67640919
36Cerebral inclusion bodies (HP:0100314)2.63171937
37Failure to thrive in infancy (HP:0001531)2.62039031
38Neurofibrillary tangles (HP:0002185)2.61655666
39Sleep apnea (HP:0010535)2.59570432
40Agitation (HP:0000713)2.58528241
41Hypsarrhythmia (HP:0002521)2.58431934
42Gaze-evoked nystagmus (HP:0000640)2.58403236
43Pheochromocytoma (HP:0002666)2.56128939
44Abnormality of the labia minora (HP:0012880)2.54968833
45Papilledema (HP:0001085)2.50101886
46Cerebral hypomyelination (HP:0006808)2.49273001
47Gait imbalance (HP:0002141)2.45533418
48Hemiparesis (HP:0001269)2.44371041
49Mutism (HP:0002300)2.41002985
50Urinary bladder sphincter dysfunction (HP:0002839)2.39386586
51Impaired smooth pursuit (HP:0007772)2.32736385
52Megalencephaly (HP:0001355)2.31306121
53Postural instability (HP:0002172)2.28510530
54Akinesia (HP:0002304)2.28004326
55Neuroendocrine neoplasm (HP:0100634)2.25491434
56Spastic gait (HP:0002064)2.24815344
57Scanning speech (HP:0002168)2.23659352
58Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.22842079
59Degeneration of the lateral corticospinal tracts (HP:0002314)2.22842079
60Absent/shortened dynein arms (HP:0200106)2.21825757
61Dynein arm defect of respiratory motile cilia (HP:0012255)2.21825757
62Inability to walk (HP:0002540)2.21498053
63Intention tremor (HP:0002080)2.21396648
64Bradykinesia (HP:0002067)2.19396986
65Genetic anticipation (HP:0003743)2.16873777
66Absent speech (HP:0001344)2.16644386
67Torticollis (HP:0000473)2.13813380
68Stereotypic behavior (HP:0000733)2.11111768
69Morphological abnormality of the pyramidal tract (HP:0002062)2.10566408
70Thickened helices (HP:0000391)2.10427174
71Congenital primary aphakia (HP:0007707)2.10233847
72Generalized myoclonic seizures (HP:0002123)2.10065060
73Psychosis (HP:0000709)2.08843775
74CNS hypomyelination (HP:0003429)2.07840247
75Focal dystonia (HP:0004373)2.07423442
76Abnormality of salivation (HP:0100755)2.07106026
77Abnormal ciliary motility (HP:0012262)2.06987388
78Spastic tetraplegia (HP:0002510)2.06936440
79Urinary urgency (HP:0000012)2.05584439
80Hyperthyroidism (HP:0000836)2.05580301
81Diplopia (HP:0000651)2.05461104
82Abnormality of binocular vision (HP:0011514)2.05461104
83Medial flaring of the eyebrow (HP:0010747)2.04678905
84Abnormality of the lower motor neuron (HP:0002366)2.04260349
85Protruding tongue (HP:0010808)2.02831156
86Split foot (HP:0001839)1.98587352
87Specific learning disability (HP:0001328)1.97409355
88Hypoventilation (HP:0002791)1.95871021
89Termporal pattern (HP:0011008)1.95800885
90Insidious onset (HP:0003587)1.95800885
91Blue irides (HP:0000635)1.95705437
92Abnormality of ocular smooth pursuit (HP:0000617)1.95005493
93Retinal dysplasia (HP:0007973)1.94121115
94Lissencephaly (HP:0001339)1.93799254
95Delusions (HP:0000746)1.92912275
96Vaginal atresia (HP:0000148)1.92178323
97Nephrogenic diabetes insipidus (HP:0009806)1.91160501
98Genital tract atresia (HP:0001827)1.89368624
99Abnormality of calcium-phosphate metabolism (HP:0100530)1.89292987
100Abnormality of the corticospinal tract (HP:0002492)1.89015262
101Abnormal hair whorl (HP:0010721)1.88627459
102Lower limb muscle weakness (HP:0007340)1.85212414
103Fetal akinesia sequence (HP:0001989)1.84922413
104Spastic tetraparesis (HP:0001285)1.84579019
105Abnormal respiratory motile cilium morphology (HP:0005938)1.83941786
106Abnormal respiratory epithelium morphology (HP:0012253)1.83941786
107Craniofacial dystonia (HP:0012179)1.83468594
108Hemiplegia (HP:0002301)1.83368920
109Menstrual irregularities (HP:0000858)1.83268207
110Abnormal respiratory motile cilium physiology (HP:0012261)1.82537064
111Status epilepticus (HP:0002133)1.82508478
112Poor suck (HP:0002033)1.81980808
113Neuronal loss in central nervous system (HP:0002529)1.80651617
114Gait ataxia (HP:0002066)1.78924057
115Nephronophthisis (HP:0000090)1.78751834
116Type II lissencephaly (HP:0007260)1.77803290
117Amyotrophic lateral sclerosis (HP:0007354)1.77761666
118Esotropia (HP:0000565)1.76752369
119Peripheral hypomyelination (HP:0007182)1.75175217
120Optic nerve hypoplasia (HP:0000609)1.71966570
121Tetraplegia (HP:0002445)1.70906860
122Hypoplasia of the corpus callosum (HP:0002079)1.70586350
123Muscular hypotonia of the trunk (HP:0008936)1.69151568
124Hypoplasia of the brainstem (HP:0002365)1.67286554
125Aplasia/Hypoplasia of the brainstem (HP:0007362)1.67286554
126Incomplete penetrance (HP:0003829)1.64920337
127Pancreatic fibrosis (HP:0100732)1.64449649
128Pachygyria (HP:0001302)1.63573741
129Annular pancreas (HP:0001734)1.58638724
130Impaired vibratory sensation (HP:0002495)1.58579571
131Cortical dysplasia (HP:0002539)1.58000348
132Poor coordination (HP:0002370)1.55524876

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.72235631
2EPHA43.99078192
3MAP3K93.46362507
4MAP3K43.00363482
5MARK12.93683724
6MAP3K122.64918871
7CASK2.53664708
8MAP2K72.52561797
9MINK12.51601235
10NTRK22.19874984
11DAPK22.05042498
12MAP2K41.97781355
13PNCK1.92728584
14RIPK41.81737679
15PAK61.81664171
16NTRK11.79983818
17TNIK1.77902847
18DYRK21.73256047
19ARAF1.71380154
20KSR21.71178038
21KSR11.60398571
22PRKD31.58432157
23UHMK11.57318864
24CDK51.53729386
25PLK21.48235986
26GRK51.47068209
27CDK191.46366064
28MAPK131.42261028
29DAPK11.41021382
30CAMKK11.25829663
31PRKCG1.23194685
32SIK21.23086779
33PRPF4B1.18436119
34CSNK1G31.17038790
35MAP3K21.16495707
36FES1.16119183
37CAMK2A1.11990509
38FGFR21.10676375
39CAMK2B1.07478201
40MAP3K131.05507074
41MAP4K21.02283620
42NME11.01531284
43OXSR11.00259805
44CSNK1A1L0.99712172
45WNK30.98482029
46CSNK1G10.98311863
47TRIM280.96827734
48CAMKK20.95183818
49BMPR20.94736537
50INSRR0.94187299
51PAK30.92559870
52SGK2230.91949138
53SGK4940.91949138
54BRAF0.90123523
55AKT30.89756488
56CDK180.88066218
57TYRO30.86028677
58CDK140.84776332
59STK380.84659041
60CDK150.83266877
61DYRK1A0.82765442
62PKN10.81944398
63PHKG20.81176677
64PHKG10.81176677
65SIK30.76394837
66LIMK10.76215963
67TNK20.74657274
68CSNK1G20.72567308
69CAMK10.72204788
70CAMK2D0.72176363
71PTK2B0.71579904
72CDK11A0.71120598
73PRKCH0.70553349
74GRK70.70142567
75RAF10.68930867
76BCR0.67533914
77MAP3K10.67528019
78BRSK10.66664640
79SGK10.65531935
80PRKCE0.65073585
81STK110.64872326
82SGK20.63362427
83CAMK40.63308220
84ALK0.62692530
85FER0.62288738
86PINK10.61154480
87RET0.60767682
88MAPK150.58437001
89MARK20.58016111
90WNK40.56954032
91BMPR1B0.54957404
92NEK60.53022743
93CDC42BPA0.52542852
94CAMK2G0.52477203
95PRKCZ0.52355065
96CSNK1E0.47512188
97TAOK10.45979529
98ADRBK20.45953490
99PDPK10.45830747
100FGR0.45591903
101LATS20.44863944
102CSNK1D0.43772050
103MAPK100.43705760
104PDK10.43186782
105RPS6KA30.42933848
106CSNK1A10.41497805
107MAP2K10.40596527
108ADRBK10.40238080
109CAMK1G0.39715458
110FYN0.38102861
111PRKACA0.36562530
112SGK30.36242368
113CCNB10.35920562
114ROCK20.35792730
115MKNK20.35550292
116PRKDC0.34998484
117PLK30.33724997
118PRKG10.33498320
119IRAK20.33154403
120MAPKAPK50.33120528
121PRKCB0.33036451
122EPHB20.32119823
123ERBB30.31608875
124PRKCA0.30964405
125GSK3B0.29811086
126FRK0.29484511
127ERBB20.29063950
128LMTK20.28945084

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.95497864
2Synaptic vesicle cycle_Homo sapiens_hsa047213.35971215
3GABAergic synapse_Homo sapiens_hsa047272.82716604
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.78251518
5Olfactory transduction_Homo sapiens_hsa047402.75499274
6Circadian entrainment_Homo sapiens_hsa047132.69148793
7Long-term potentiation_Homo sapiens_hsa047202.62339698
8Amphetamine addiction_Homo sapiens_hsa050312.61161627
9Morphine addiction_Homo sapiens_hsa050322.59549797
10Glutamatergic synapse_Homo sapiens_hsa047242.48307362
11Insulin secretion_Homo sapiens_hsa049112.34198745
12Dopaminergic synapse_Homo sapiens_hsa047282.23362667
13Collecting duct acid secretion_Homo sapiens_hsa049662.12208841
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.08080084
15Taste transduction_Homo sapiens_hsa047422.03432366
16Salivary secretion_Homo sapiens_hsa049702.01812320
17Cocaine addiction_Homo sapiens_hsa050301.93708760
18Serotonergic synapse_Homo sapiens_hsa047261.92892231
19Cholinergic synapse_Homo sapiens_hsa047251.82573763
20Renin secretion_Homo sapiens_hsa049241.81491188
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.76894498
22Long-term depression_Homo sapiens_hsa047301.73317686
23Gastric acid secretion_Homo sapiens_hsa049711.71511739
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.67494624
25Vibrio cholerae infection_Homo sapiens_hsa051101.61870076
26Oxytocin signaling pathway_Homo sapiens_hsa049211.55545380
27Calcium signaling pathway_Homo sapiens_hsa040201.54035686
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50124632
29GnRH signaling pathway_Homo sapiens_hsa049121.36162029
30Gap junction_Homo sapiens_hsa045401.32747175
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30742639
32Oxidative phosphorylation_Homo sapiens_hsa001901.24747675
33Type II diabetes mellitus_Homo sapiens_hsa049301.22495345
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21246357
35Cardiac muscle contraction_Homo sapiens_hsa042601.20638855
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18433521
37cAMP signaling pathway_Homo sapiens_hsa040241.17175003
38Estrogen signaling pathway_Homo sapiens_hsa049151.12586551
39Vitamin B6 metabolism_Homo sapiens_hsa007501.09750656
40Alzheimers disease_Homo sapiens_hsa050101.06630931
41Axon guidance_Homo sapiens_hsa043601.03400272
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02946306
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01782042
44Melanogenesis_Homo sapiens_hsa049161.00820273
45Phototransduction_Homo sapiens_hsa047441.00283606
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00268788
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.98385549
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96120258
49Butanoate metabolism_Homo sapiens_hsa006500.93303100
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91682255
51Pancreatic secretion_Homo sapiens_hsa049720.89644632
52Parkinsons disease_Homo sapiens_hsa050120.89398204
53Dorso-ventral axis formation_Homo sapiens_hsa043200.87777303
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87211325
55ErbB signaling pathway_Homo sapiens_hsa040120.85667555
56Glioma_Homo sapiens_hsa052140.84311462
57Type I diabetes mellitus_Homo sapiens_hsa049400.84119107
58Thyroid hormone synthesis_Homo sapiens_hsa049180.80943057
59Oocyte meiosis_Homo sapiens_hsa041140.77847958
60Hippo signaling pathway_Homo sapiens_hsa043900.74493209
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70537209
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69492775
63Glucagon signaling pathway_Homo sapiens_hsa049220.66753511
64Prion diseases_Homo sapiens_hsa050200.66442766
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.64389512
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63853520
67Huntingtons disease_Homo sapiens_hsa050160.63258365
68Alcoholism_Homo sapiens_hsa050340.62167282
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.61393433
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61239869
71MAPK signaling pathway_Homo sapiens_hsa040100.60567049
72Choline metabolism in cancer_Homo sapiens_hsa052310.60518193
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59918659
74Dilated cardiomyopathy_Homo sapiens_hsa054140.59674895
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59494112
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59167315
77Protein export_Homo sapiens_hsa030600.57113103
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56746166
79Steroid biosynthesis_Homo sapiens_hsa001000.55341871
80Circadian rhythm_Homo sapiens_hsa047100.55076380
81Ras signaling pathway_Homo sapiens_hsa040140.50773008
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50006071
83beta-Alanine metabolism_Homo sapiens_hsa004100.49953160
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49267634
85Regulation of autophagy_Homo sapiens_hsa041400.48967062
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48940708
87Arginine and proline metabolism_Homo sapiens_hsa003300.47958845
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47887712
89Ether lipid metabolism_Homo sapiens_hsa005650.47725289
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43453590
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43342674
92Ovarian steroidogenesis_Homo sapiens_hsa049130.43057549
93Propanoate metabolism_Homo sapiens_hsa006400.43041695
94Tight junction_Homo sapiens_hsa045300.42947893
95Inositol phosphate metabolism_Homo sapiens_hsa005620.42096069
96Basal cell carcinoma_Homo sapiens_hsa052170.42056255
97VEGF signaling pathway_Homo sapiens_hsa043700.41193170
98Rheumatoid arthritis_Homo sapiens_hsa053230.41131327
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.40957069
100Wnt signaling pathway_Homo sapiens_hsa043100.37816499
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37708588
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.35298067
103Rap1 signaling pathway_Homo sapiens_hsa040150.34222170
104Renal cell carcinoma_Homo sapiens_hsa052110.33766489
105Insulin signaling pathway_Homo sapiens_hsa049100.32545454
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32288944
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30630368
108Endocytosis_Homo sapiens_hsa041440.30326248
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30085193
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29185836
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27598659
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27527490
113Nitrogen metabolism_Homo sapiens_hsa009100.27378580
114African trypanosomiasis_Homo sapiens_hsa051430.26911999
115Bile secretion_Homo sapiens_hsa049760.26001682
116Phagosome_Homo sapiens_hsa041450.25044695
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.24891530
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24841785
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24162513
120Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.23183636
1212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.21528916
122Hedgehog signaling pathway_Homo sapiens_hsa043400.21442545
123mTOR signaling pathway_Homo sapiens_hsa041500.20937363

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »