PNMAL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.24353576
2synaptic vesicle maturation (GO:0016188)6.15340112
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.84142236
4locomotory exploration behavior (GO:0035641)5.73193024
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.30598385
6vocalization behavior (GO:0071625)5.23788893
7synaptic vesicle exocytosis (GO:0016079)5.06924757
8regulation of synaptic vesicle exocytosis (GO:2000300)5.06562325
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.92662128
10L-amino acid import (GO:0043092)4.85369421
11glutamate secretion (GO:0014047)4.82479074
12regulation of glutamate receptor signaling pathway (GO:1900449)4.78520952
13cerebellar granule cell differentiation (GO:0021707)4.60498738
14neurotransmitter secretion (GO:0007269)4.60019445
15regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.59818393
16regulation of synaptic vesicle transport (GO:1902803)4.53755517
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.52246427
18exploration behavior (GO:0035640)4.46998719
19synaptic vesicle docking involved in exocytosis (GO:0016081)4.42909616
20regulation of neuronal synaptic plasticity (GO:0048168)4.41826136
21neuron cell-cell adhesion (GO:0007158)4.37828003
22protein localization to synapse (GO:0035418)4.33932728
23amino acid import (GO:0043090)4.32307527
24regulation of long-term neuronal synaptic plasticity (GO:0048169)4.28283652
25layer formation in cerebral cortex (GO:0021819)4.26684809
26gamma-aminobutyric acid transport (GO:0015812)4.23743559
27dendritic spine morphogenesis (GO:0060997)4.10807814
28neuronal action potential propagation (GO:0019227)4.10602371
29regulation of voltage-gated calcium channel activity (GO:1901385)4.08411934
30central nervous system myelination (GO:0022010)4.07694655
31axon ensheathment in central nervous system (GO:0032291)4.07694655
32regulation of synapse structural plasticity (GO:0051823)4.05295247
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.04236687
34positive regulation of synaptic transmission, GABAergic (GO:0032230)4.01818076
35negative regulation of dendrite morphogenesis (GO:0050774)3.93315074
36activation of protein kinase A activity (GO:0034199)3.90503904
37positive regulation of neurotransmitter secretion (GO:0001956)3.90446307
38synaptic transmission, glutamatergic (GO:0035249)3.90279808
39proline transport (GO:0015824)3.87538663
40glutamate receptor signaling pathway (GO:0007215)3.83945853
41cellular potassium ion homeostasis (GO:0030007)3.82121685
42neurotransmitter transport (GO:0006836)3.76939920
43long-term memory (GO:0007616)3.75128405
44regulation of synapse maturation (GO:0090128)3.71407272
45neurotransmitter-gated ion channel clustering (GO:0072578)3.68400512
46sodium ion export (GO:0071436)3.67111596
47neuromuscular process controlling posture (GO:0050884)3.64670532
48positive regulation of membrane potential (GO:0045838)3.64410854
49neuron-neuron synaptic transmission (GO:0007270)3.63603215
50positive regulation of dendritic spine morphogenesis (GO:0061003)3.62976741
51neuron recognition (GO:0008038)3.59886200
52membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.59641715
53glycine transport (GO:0015816)3.57115987
54cellular sodium ion homeostasis (GO:0006883)3.48730997
55transmission of nerve impulse (GO:0019226)3.47815582
56cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.47671364
57regulation of neurotransmitter levels (GO:0001505)3.47416420
58regulation of excitatory postsynaptic membrane potential (GO:0060079)3.47163140
59neuromuscular process controlling balance (GO:0050885)3.44493482
60regulation of dendritic spine development (GO:0060998)3.44186250
61cerebellar Purkinje cell layer development (GO:0021680)3.43028740
62neuronal ion channel clustering (GO:0045161)3.38126301
63cell communication by electrical coupling (GO:0010644)3.36441179
64regulation of synaptic plasticity (GO:0048167)3.35564202
65synaptic vesicle endocytosis (GO:0048488)3.35443667
66cerebellar Purkinje cell differentiation (GO:0021702)3.34329626
67regulation of postsynaptic membrane potential (GO:0060078)3.32171496
68positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.31401827
69positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.30706161
70vesicle transport along microtubule (GO:0047496)3.30275598
71acidic amino acid transport (GO:0015800)3.29580322
72regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.29354264
73regulation of vesicle fusion (GO:0031338)3.29039852
74neurotransmitter uptake (GO:0001504)3.28894031
75auditory behavior (GO:0031223)3.28397590
76axonal fasciculation (GO:0007413)3.25687671
77positive regulation of synapse maturation (GO:0090129)3.23873276
78regulation of neurotransmitter secretion (GO:0046928)3.23114622
79neuromuscular synaptic transmission (GO:0007274)3.22567025
80synaptic vesicle transport (GO:0048489)3.20758373
81establishment of synaptic vesicle localization (GO:0097480)3.20758373
82synaptic transmission (GO:0007268)3.20336104
83postsynaptic membrane organization (GO:0001941)3.19517778
84dendrite morphogenesis (GO:0048813)3.19204959
85gamma-aminobutyric acid signaling pathway (GO:0007214)3.18057866
86regulation of dendritic spine morphogenesis (GO:0061001)3.18050610
87vesicle docking involved in exocytosis (GO:0006904)3.17772170
88response to auditory stimulus (GO:0010996)3.17702745
89prepulse inhibition (GO:0060134)3.16541693
90negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.15738587
91cytoskeletal anchoring at plasma membrane (GO:0007016)3.15369060
92long-term synaptic potentiation (GO:0060291)3.12224543
93regulation of synaptic transmission, glutamatergic (GO:0051966)3.10623470
94mating behavior (GO:0007617)3.05618451
95detection of calcium ion (GO:0005513)3.04838455
96regulation of exocytosis (GO:0017157)3.04824489
97social behavior (GO:0035176)3.03749887
98intraspecies interaction between organisms (GO:0051703)3.03749887
99membrane depolarization during action potential (GO:0086010)3.03030345
100regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.03013192
101regulation of calcium ion-dependent exocytosis (GO:0017158)3.02628188
102regulation of ARF protein signal transduction (GO:0032012)3.01888812
103regulation of neurotransmitter transport (GO:0051588)3.00735276
104dendritic spine organization (GO:0097061)2.99674861
105cell differentiation in hindbrain (GO:0021533)2.99653714
106regulation of synaptic transmission, GABAergic (GO:0032228)2.97790908
107vesicle docking (GO:0048278)2.96615488
108dicarboxylic acid transport (GO:0006835)2.95031829
109membrane hyperpolarization (GO:0060081)2.94889328
110potassium ion import (GO:0010107)2.94784560
111positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.94350397
112membrane depolarization (GO:0051899)2.93905848
113chemosensory behavior (GO:0007635)2.93383350
114negative regulation of synaptic transmission, GABAergic (GO:0032229)2.92757089
115response to pheromone (GO:0019236)2.92187832
116organelle transport along microtubule (GO:0072384)2.91677694
117innervation (GO:0060384)2.91419363
118positive regulation of synaptic transmission (GO:0050806)2.90153171
119positive regulation of dendritic spine development (GO:0060999)2.89229709
120regulation of synaptic transmission (GO:0050804)2.88695546
121learning (GO:0007612)2.88570619
122potassium ion homeostasis (GO:0055075)2.87875441
123positive regulation of neurotransmitter transport (GO:0051590)2.86930551
124synapse assembly (GO:0007416)2.86902688
125neuromuscular process (GO:0050905)2.86463953
126G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.85280261

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.02543473
2GBX2_23144817_ChIP-Seq_PC3_Human3.04985907
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.04304028
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.99990109
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.95017800
6REST_21632747_ChIP-Seq_MESCs_Mouse2.91155850
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.71772527
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63626774
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63626774
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.63244585
11DROSHA_22980978_ChIP-Seq_HELA_Human2.60789765
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.60127570
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.52681094
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.49844032
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49381494
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.48203241
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.47824367
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46559931
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45356076
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.42619633
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.33109742
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.32736100
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.24602701
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.19525441
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.19439506
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.17677331
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.09336918
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.03558661
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87224134
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85407327
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.65076331
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62298695
33AR_21572438_ChIP-Seq_LNCaP_Human1.56815759
34ZNF274_21170338_ChIP-Seq_K562_Hela1.52842615
35SMAD4_21799915_ChIP-Seq_A2780_Human1.49543896
36RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.43362470
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40033601
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38369882
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.37643676
40DNAJC2_21179169_ChIP-ChIP_NT2_Human1.36726574
41NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31391512
42TAF15_26573619_Chip-Seq_HEK293_Human1.29105470
43SOX2_21211035_ChIP-Seq_LN229_Gbm1.29082446
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25205187
45AR_19668381_ChIP-Seq_PC3_Human1.23169075
46ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21184537
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20593636
48WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19570453
49SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19427589
50IGF1R_20145208_ChIP-Seq_DFB_Human1.18779479
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18662078
52KDM2B_26808549_Chip-Seq_K562_Human1.18267334
53EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17643714
54CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17023959
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16733799
56STAT3_23295773_ChIP-Seq_U87_Human1.16196301
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13340585
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.12780019
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.11974324
60RING1B_27294783_Chip-Seq_NPCs_Mouse1.11787905
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11542042
62GATA1_26923725_Chip-Seq_HPCs_Mouse1.11185775
63AR_25329375_ChIP-Seq_VCAP_Human1.10485961
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09216220
65LXR_22292898_ChIP-Seq_THP-1_Human1.09073358
66P300_19829295_ChIP-Seq_ESCs_Human1.08889252
67WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08245106
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06317925
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05538206
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04204264
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02881999
72ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02766947
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02668159
74YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02553874
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01568648
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00215406
77MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00173405
78PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99770439
79ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99763351
80ESR2_21235772_ChIP-Seq_MCF-7_Human0.99066214
81SMAD3_21741376_ChIP-Seq_ESCs_Human0.98828738
82OCT4_19829295_ChIP-Seq_ESCs_Human0.98818964
83P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98695547
84TCF4_23295773_ChIP-Seq_U87_Human0.98490034
85RNF2_27304074_Chip-Seq_NSC_Mouse0.97880519
86PIAS1_25552417_ChIP-Seq_VCAP_Human0.97058361
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96324272
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95487978
89CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94488868
90SMAD_19615063_ChIP-ChIP_OVARY_Human0.94487956
91RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94156353
92ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93656826
93CTCF_27219007_Chip-Seq_Bcells_Human0.93220953
94ARNT_22903824_ChIP-Seq_MCF-7_Human0.92112765
95TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91585648
96SMAD4_21741376_ChIP-Seq_HESCs_Human0.90483746
97* TET1_21490601_ChIP-Seq_MESCs_Mouse0.90320894
98SMC4_20622854_ChIP-Seq_HELA_Human0.90170883
99* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.89612175
100AHR_22903824_ChIP-Seq_MCF-7_Human0.89593378
101NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88788914
102PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88704146
103* DPY_21335234_ChIP-Seq_ESCs_Mouse0.88480685
104KLF4_19829295_ChIP-Seq_ESCs_Human0.87209632
105TP53_20018659_ChIP-ChIP_R1E_Mouse0.87168492
106SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.87126283
107RUNX2_22187159_ChIP-Seq_PCA_Human0.86984878
108GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86550877
109ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86247351
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84966061
111SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84772711
112PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.84584830
113SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84385131
114VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.81429724
115STAT6_21828071_ChIP-Seq_BEAS2B_Human0.81211888
116CTNNB1_20460455_ChIP-Seq_HCT116_Human0.81107840
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80938640
118DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.80644048
119SMAD3_21741376_ChIP-Seq_HESCs_Human0.79988279
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78526419
121SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.77825906
122EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.76093333
123SMAD4_21741376_ChIP-Seq_ESCs_Human0.74918804
124RUNX1_26923725_Chip-Seq_HPCs_Mouse0.74328041
125MYC_19915707_ChIP-ChIP_AK7_Human0.73299616
126TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.72481802
127CREB1_26743006_Chip-Seq_LNCaP_Human0.71875707
128P68_20966046_ChIP-Seq_HELA_Human0.70224618
129LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.70048536

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.18763620
2MP0003880_abnormal_central_pattern4.56238554
3MP0003635_abnormal_synaptic_transmissio4.05199989
4MP0004270_analgesia3.56089200
5MP0009745_abnormal_behavioral_response3.28387934
6MP0002063_abnormal_learning/memory/cond3.17202744
7MP0005423_abnormal_somatic_nervous3.12516607
8MP0002064_seizures3.08321219
9MP0009046_muscle_twitch2.96307545
10MP0002572_abnormal_emotion/affect_behav2.69008580
11MP0001968_abnormal_touch/_nociception2.59059027
12MP0002734_abnormal_mechanical_nocicepti2.51140787
13MP0002272_abnormal_nervous_system2.49524205
14MP0002822_catalepsy2.45517996
15MP0001486_abnormal_startle_reflex2.41859553
16MP0002909_abnormal_adrenal_gland2.40850699
17MP0009780_abnormal_chondrocyte_physiolo2.32260152
18MP0001501_abnormal_sleep_pattern2.29207795
19MP0005645_abnormal_hypothalamus_physiol2.07440865
20MP0002733_abnormal_thermal_nociception2.02782725
21MP0001440_abnormal_grooming_behavior2.00952402
22MP0003122_maternal_imprinting2.00836851
23MP0001970_abnormal_pain_threshold1.90178757
24MP0005646_abnormal_pituitary_gland1.90073605
25MP0003329_amyloid_beta_deposits1.86324275
26MP0002736_abnormal_nociception_after1.85753089
27MP0008569_lethality_at_weaning1.84929008
28MP0002067_abnormal_sensory_capabilities1.81994873
29MP0002735_abnormal_chemical_nociception1.77903094
30MP0003283_abnormal_digestive_organ1.77718466
31MP0002557_abnormal_social/conspecific_i1.76560040
32MP0003787_abnormal_imprinting1.76521482
33MP0006276_abnormal_autonomic_nervous1.76418194
34MP0002184_abnormal_innervation1.74480522
35MP0004811_abnormal_neuron_physiology1.73755634
36MP0004885_abnormal_endolymph1.67271136
37MP0000778_abnormal_nervous_system1.66243619
38MP0004924_abnormal_behavior1.65909347
39MP0005386_behavior/neurological_phenoty1.65909347
40MP0004858_abnormal_nervous_system1.63955968
41MP0000955_abnormal_spinal_cord1.63320592
42MP0000013_abnormal_adipose_tissue1.60393170
43MP0001984_abnormal_olfaction1.47382786
44MP0003879_abnormal_hair_cell1.47368884
45MP0002066_abnormal_motor_capabilities/c1.41019931
46MP0002882_abnormal_neuron_morphology1.38926615
47MP0001502_abnormal_circadian_rhythm1.38315107
48MP0003633_abnormal_nervous_system1.32687629
49MP0004142_abnormal_muscle_tone1.23193148
50MP0008961_abnormal_basal_metabolism1.22852564
51MP0001529_abnormal_vocalization1.22472273
52MP0010386_abnormal_urinary_bladder1.16438674
53MP0001905_abnormal_dopamine_level1.08048029
54MP0002152_abnormal_brain_morphology1.07749410
55MP0004043_abnormal_pH_regulation1.06960062
56MP0004145_abnormal_muscle_electrophysio1.06593457
57MP0003631_nervous_system_phenotype1.06499388
58MP0002229_neurodegeneration1.03026737
59MP0002069_abnormal_eating/drinking_beha1.02431545
60MP0003634_abnormal_glial_cell0.97530403
61MP0003690_abnormal_glial_cell0.96191943
62MP0000751_myopathy0.95017395
63MP0000631_abnormal_neuroendocrine_gland0.93002812
64MP0005535_abnormal_body_temperature0.92830461
65MP0002638_abnormal_pupillary_reflex0.90515002
66MP0001346_abnormal_lacrimal_gland0.90371193
67MP0002837_dystrophic_cardiac_calcinosis0.90258472
68MP0005551_abnormal_eye_electrophysiolog0.87491487
69MP0006072_abnormal_retinal_apoptosis0.86966921
70MP0004085_abnormal_heartbeat0.83467441
71MP0003123_paternal_imprinting0.83136539
72MP0003075_altered_response_to0.82801930
73MP0008872_abnormal_physiological_respon0.81533623
74MP0003172_abnormal_lysosome_physiology0.80463821
75MP0001177_atelectasis0.80248679
76MP0001188_hyperpigmentation0.79020367
77MP0000569_abnormal_digit_pigmentation0.78848521
78MP0004742_abnormal_vestibular_system0.78114564
79MP0005499_abnormal_olfactory_system0.77762682
80MP0005394_taste/olfaction_phenotype0.77762682
81MP0000920_abnormal_myelination0.77755006
82MP0000604_amyloidosis0.76192503
83MP0001348_abnormal_lacrimal_gland0.75650863
84MP0004147_increased_porphyrin_level0.75119977
85MP0003632_abnormal_nervous_system0.74789340
86MP0004130_abnormal_muscle_cell0.74401875
87MP0008874_decreased_physiological_sensi0.72980613
88MP0003121_genomic_imprinting0.71882967
89MP0001299_abnormal_eye_distance/0.71002550
90MP0005167_abnormal_blood-brain_barrier0.70678127
91MP0005623_abnormal_meninges_morphology0.70363793
92MP0001963_abnormal_hearing_physiology0.70263913
93MP0003183_abnormal_peptide_metabolism0.70181071
94MP0005379_endocrine/exocrine_gland_phen0.70159371
95MP0003137_abnormal_impulse_conducting0.67422586
96MP0002752_abnormal_somatic_nervous0.67366378
97MP0002234_abnormal_pharynx_morphology0.66643800
98MP0001986_abnormal_taste_sensitivity0.65745367
99MP0004233_abnormal_muscle_weight0.65678929
100MP0002090_abnormal_vision0.64087385
101MP0001485_abnormal_pinna_reflex0.63713480
102MP0010234_abnormal_vibrissa_follicle0.63351411
103MP0001944_abnormal_pancreas_morphology0.61538949
104MP0001664_abnormal_digestion0.61456273
105MP0002693_abnormal_pancreas_physiology0.60764670
106MP0008877_abnormal_DNA_methylation0.60702205
107MP0000003_abnormal_adipose_tissue0.60232215
108MP0010769_abnormal_survival0.54452555
109MP0000579_abnormal_nail_morphology0.53348644
110MP0000026_abnormal_inner_ear0.51351785
111MP0010768_mortality/aging0.51230659
112MP0000639_abnormal_adrenal_gland0.50584255
113MP0001943_abnormal_respiration0.50036708
114MP0002082_postnatal_lethality0.49968569
115MP0010770_preweaning_lethality0.49968569
116MP0003956_abnormal_body_size0.49541033
117MP0003861_abnormal_nervous_system0.46690703
118MP0003938_abnormal_ear_development0.46078351
119MP0005166_decreased_susceptibility_to0.45554229
120MP0002873_normal_phenotype0.43530294

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.60028229
2Myokymia (HP:0002411)6.13243372
3Visual hallucinations (HP:0002367)5.55074492
4Focal seizures (HP:0007359)5.15883683
5Supranuclear gaze palsy (HP:0000605)4.11634453
6Epileptic encephalopathy (HP:0200134)4.10324676
7Atonic seizures (HP:0010819)4.04241524
8Progressive cerebellar ataxia (HP:0002073)3.89740791
9Absence seizures (HP:0002121)3.82148061
10Annular pancreas (HP:0001734)3.68841231
11Action tremor (HP:0002345)3.68655957
12Generalized tonic-clonic seizures (HP:0002069)3.68071992
13Ankle clonus (HP:0011448)3.66946116
14Febrile seizures (HP:0002373)3.65748318
15Depression (HP:0000716)3.54415453
16Papilledema (HP:0001085)3.53295305
17Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.44632565
18Cerebral hypomyelination (HP:0006808)3.43150987
19Dialeptic seizures (HP:0011146)3.41699797
20Anxiety (HP:0000739)3.25828901
21Obstructive sleep apnea (HP:0002870)3.23571293
22Tetraplegia (HP:0002445)3.23541995
23Mutism (HP:0002300)3.17765676
24Delusions (HP:0000746)3.17013536
25Abnormal eating behavior (HP:0100738)3.16079336
26Akinesia (HP:0002304)3.12851198
27Postural instability (HP:0002172)3.12141373
28Impaired vibration sensation in the lower limbs (HP:0002166)3.05065176
29Poor eye contact (HP:0000817)3.04801872
30Broad-based gait (HP:0002136)2.94171004
31Truncal ataxia (HP:0002078)2.93793092
32Agitation (HP:0000713)2.90873607
33Dysdiadochokinesis (HP:0002075)2.87872424
34Neurofibrillary tangles (HP:0002185)2.87459315
35Urinary bladder sphincter dysfunction (HP:0002839)2.84660779
36Impaired social interactions (HP:0000735)2.83074818
37Abnormal social behavior (HP:0012433)2.83074818
38Hemiparesis (HP:0001269)2.78926408
39Dysmetria (HP:0001310)2.78365930
40Ventricular fibrillation (HP:0001663)2.74699215
41Abnormality of the lower motor neuron (HP:0002366)2.73637555
42Cerebral inclusion bodies (HP:0100314)2.69430201
43Progressive inability to walk (HP:0002505)2.65092621
44Genetic anticipation (HP:0003743)2.64913765
45Gaze-evoked nystagmus (HP:0000640)2.61498220
46Spastic gait (HP:0002064)2.61036426
47Torticollis (HP:0000473)2.59763659
48Excessive salivation (HP:0003781)2.58634638
49Drooling (HP:0002307)2.58634638
50Hemiplegia (HP:0002301)2.58470799
51Sleep apnea (HP:0010535)2.53759897
52Impaired smooth pursuit (HP:0007772)2.53089444
53Bradykinesia (HP:0002067)2.52483835
54Peripheral hypomyelination (HP:0007182)2.52410698
55EEG with generalized epileptiform discharges (HP:0011198)2.51224992
56Epileptiform EEG discharges (HP:0011182)2.50973370
57Amblyopia (HP:0000646)2.49431489
58Pheochromocytoma (HP:0002666)2.49287495
59Intention tremor (HP:0002080)2.47306103
60Insomnia (HP:0100785)2.47230727
61Limb dystonia (HP:0002451)2.47180875
62Megalencephaly (HP:0001355)2.45624484
63Hypsarrhythmia (HP:0002521)2.44079423
64Urinary urgency (HP:0000012)2.42834134
65Focal dystonia (HP:0004373)2.39314420
66Diminished motivation (HP:0000745)2.37090421
67Spastic tetraparesis (HP:0001285)2.33580627
68Hyperventilation (HP:0002883)2.31367644
69Polyphagia (HP:0002591)2.31144169
70Abnormality of binocular vision (HP:0011514)2.29247668
71Diplopia (HP:0000651)2.29247668
72Failure to thrive in infancy (HP:0001531)2.27527776
73Scanning speech (HP:0002168)2.20456983
74Morphological abnormality of the pyramidal tract (HP:0002062)2.19303982
75Lower limb muscle weakness (HP:0007340)2.19301287
76Abnormality of ocular smooth pursuit (HP:0000617)2.18519413
77Choreoathetosis (HP:0001266)2.16701980
78Stereotypic behavior (HP:0000733)2.16670375
79Degeneration of the lateral corticospinal tracts (HP:0002314)2.14786016
80Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.14786016
81Craniofacial dystonia (HP:0012179)2.14311008
82Amyotrophic lateral sclerosis (HP:0007354)2.14279167
83Abnormality of calcium-phosphate metabolism (HP:0100530)2.13612171
84Incomplete penetrance (HP:0003829)2.13014094
85CNS hypomyelination (HP:0003429)2.11148558
86Hypoventilation (HP:0002791)2.08574966
87Neuronal loss in central nervous system (HP:0002529)2.07213177
88Neuroendocrine neoplasm (HP:0100634)2.07110615
89Bundle branch block (HP:0011710)2.06819554
90Clonus (HP:0002169)2.06451185
91Abnormality of the corticospinal tract (HP:0002492)2.05763121
92Status epilepticus (HP:0002133)2.04287380
93Psychosis (HP:0000709)2.03840795
94Hypercortisolism (HP:0001578)1.99725263
95Menstrual irregularities (HP:0000858)1.99544792
96Abnormal EKG (HP:0003115)1.99461331
97Pointed chin (HP:0000307)1.99376949
98Insidious onset (HP:0003587)1.96236247
99Termporal pattern (HP:0011008)1.96236247
100Neoplasm of the heart (HP:0100544)1.96065839
101Generalized myoclonic seizures (HP:0002123)1.95405241
102Spinal canal stenosis (HP:0003416)1.94086228
103Aplasia involving bones of the upper limbs (HP:0009823)1.93546793
104Aplasia of the phalanges of the hand (HP:0009802)1.93546793
105Aplasia involving bones of the extremities (HP:0009825)1.93546793
106Fetal akinesia sequence (HP:0001989)1.92453116
107Abnormality of saccadic eye movements (HP:0000570)1.91758119
108Blue irides (HP:0000635)1.90636648
109Resting tremor (HP:0002322)1.90123974
110Increased circulating renin level (HP:0000848)1.90113538
111Lower limb asymmetry (HP:0100559)1.89679806
112Impaired vibratory sensation (HP:0002495)1.89572166
113Rigidity (HP:0002063)1.89522306
114Dysmetric saccades (HP:0000641)1.85859302
115Absent speech (HP:0001344)1.85694967
116Split foot (HP:0001839)1.85421862
117Lower limb amyotrophy (HP:0007210)1.85294404
118Rapidly progressive (HP:0003678)1.84628377
119Ankyloglossia (HP:0010296)1.84371563
120Memory impairment (HP:0002354)1.83655555
121Gait ataxia (HP:0002066)1.81428479
122Prolonged QT interval (HP:0001657)1.78285630
123Postural tremor (HP:0002174)1.77894819
124Bronchomalacia (HP:0002780)1.77501017
125Dementia (HP:0000726)1.76965414
126Macroorchidism (HP:0000053)1.76653698
127Apathy (HP:0000741)1.75477802
128Slow saccadic eye movements (HP:0000514)1.69536220

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.62154550
2MAP3K94.07986024
3EPHA43.51198553
4MARK13.32614935
5MAP3K42.85357944
6MINK12.64748005
7PRKD32.56640194
8NTRK22.40609974
9PAK62.36522505
10KSR22.24809472
11MAP2K72.17463140
12DAPK22.07483534
13NTRK12.06031243
14CAMKK11.83274090
15MAP2K41.74882722
16MAP3K121.73012130
17UHMK11.65178914
18CDK51.60434104
19ARAF1.55372786
20KSR11.53965051
21TNIK1.47765147
22MAP3K21.44328753
23STK381.40415247
24PNCK1.32981975
25GRK51.31563126
26MAP3K131.30497305
27SIK21.29418669
28FES1.25284808
29MAPK131.23943336
30RIPK41.23884567
31PRKCG1.18340666
32PRKCH1.17916888
33TYRO31.13055746
34DAPK11.08967488
35PHKG21.08442919
36PHKG11.08442919
37WNK31.07506661
38PLK21.06691200
39CAMKK21.06505887
40CDK191.04174394
41PRPF4B1.02361589
42PAK31.00773417
43CASK1.00608615
44ALK1.00517858
45SGK4940.97465184
46SGK2230.97465184
47MAP3K10.96662939
48TAOK10.94932498
49CAMK2A0.91056411
50STK110.90806454
51CAMK10.90004910
52LATS20.88956544
53MAPK120.88623507
54CDK180.87116209
55CDK150.87097741
56PINK10.86474890
57MAP3K110.86244962
58CDK140.85778626
59RET0.84379377
60INSRR0.82081529
61LMTK20.80227429
62CAMK2B0.78209993
63CDC42BPA0.76858170
64CDK11A0.75470310
65SCYL20.74774863
66MARK20.74537706
67SGK30.73878378
68SGK20.73848598
69DYRK1A0.73438119
70PKN10.71883877
71TNK20.67485551
72RAF10.67256655
73SGK10.67157308
74CSNK1G20.66250350
75DAPK30.65559894
76WNK10.65173799
77CAMK1G0.63614497
78LIMK10.60893443
79TESK10.58873081
80PDPK10.56694471
81PDK10.55966756
82CAMK2D0.55716308
83RPS6KA30.54483306
84OXSR10.53274956
85FER0.52687758
86PRKCZ0.52010030
87HIPK20.51355217
88WNK40.49044257
89MAPK100.48974029
90NEK60.48727355
91RIPK10.48353747
92BRSK10.47368602
93PRKCE0.47081175
94RPS6KA20.46312485
95CAMK2G0.45929822
96PDGFRA0.45528646
97MAPKAPK50.44941990
98MAPK150.44663744
99FYN0.44572458
100ROCK20.44333166
101PTK2B0.40997635
102FGFR20.40675941
103MAP2K10.38407686
104CAMK40.37761506
105BMPR20.37358029
106BRAF0.36665615
107PRKG20.36251995
108PRKCA0.35849663
109PRKD20.34574810
110MAP3K70.32832822
111PRKCB0.32435757
112CCNB10.32283181
113ROCK10.28058067
114MAPK80.26957657
115ERBB20.26600299
116PRKG10.25229202
117MAPK40.25039136
118PRKACA0.24099110
119MAP2K60.23936609

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.47657903
2Synaptic vesicle cycle_Homo sapiens_hsa047213.28391776
3GABAergic synapse_Homo sapiens_hsa047272.87836068
4Circadian entrainment_Homo sapiens_hsa047132.61422295
5Olfactory transduction_Homo sapiens_hsa047402.59620501
6Long-term potentiation_Homo sapiens_hsa047202.50603514
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.50084123
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.43978231
9Glutamatergic synapse_Homo sapiens_hsa047242.43331778
10Amphetamine addiction_Homo sapiens_hsa050312.42828319
11Morphine addiction_Homo sapiens_hsa050322.42161863
12Insulin secretion_Homo sapiens_hsa049112.40701242
13Dopaminergic synapse_Homo sapiens_hsa047282.12500336
14Salivary secretion_Homo sapiens_hsa049702.00629475
15Cocaine addiction_Homo sapiens_hsa050301.94318785
16Gastric acid secretion_Homo sapiens_hsa049711.86678546
17Cholinergic synapse_Homo sapiens_hsa047251.86458054
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.84961882
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.84805381
20Taste transduction_Homo sapiens_hsa047421.81505896
21Vitamin B6 metabolism_Homo sapiens_hsa007501.65861656
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64565080
23Renin secretion_Homo sapiens_hsa049241.62019150
24Serotonergic synapse_Homo sapiens_hsa047261.61746478
25Long-term depression_Homo sapiens_hsa047301.61370990
26Type II diabetes mellitus_Homo sapiens_hsa049301.55354193
27Oxytocin signaling pathway_Homo sapiens_hsa049211.51757262
28Calcium signaling pathway_Homo sapiens_hsa040201.42701640
29GnRH signaling pathway_Homo sapiens_hsa049121.42071431
30Gap junction_Homo sapiens_hsa045401.33063769
31Collecting duct acid secretion_Homo sapiens_hsa049661.31310057
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31263848
33cAMP signaling pathway_Homo sapiens_hsa040241.26744933
34Nitrogen metabolism_Homo sapiens_hsa009101.26346485
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24265141
36Estrogen signaling pathway_Homo sapiens_hsa049151.23177298
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18960135
38Vibrio cholerae infection_Homo sapiens_hsa051101.12627525
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10213288
40Melanogenesis_Homo sapiens_hsa049161.01721386
41Pancreatic secretion_Homo sapiens_hsa049721.01230130
42Type I diabetes mellitus_Homo sapiens_hsa049401.01223070
43Glioma_Homo sapiens_hsa052141.00922898
44Axon guidance_Homo sapiens_hsa043600.98993769
45cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97835539
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95435004
47Dorso-ventral axis formation_Homo sapiens_hsa043200.94103106
48ErbB signaling pathway_Homo sapiens_hsa040120.93302344
49Cardiac muscle contraction_Homo sapiens_hsa042600.92805228
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92737317
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.92187258
52Thyroid hormone synthesis_Homo sapiens_hsa049180.90714101
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90276783
54Oocyte meiosis_Homo sapiens_hsa041140.81767047
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.81462264
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78223220
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75581590
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75364138
59Dilated cardiomyopathy_Homo sapiens_hsa054140.72454007
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.70431905
61Phototransduction_Homo sapiens_hsa047440.69830956
62Glucagon signaling pathway_Homo sapiens_hsa049220.67386494
63MAPK signaling pathway_Homo sapiens_hsa040100.66410446
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.63501523
65Prion diseases_Homo sapiens_hsa050200.63263050
66Choline metabolism in cancer_Homo sapiens_hsa052310.62459562
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61594236
68Alcoholism_Homo sapiens_hsa050340.59966448
69Bile secretion_Homo sapiens_hsa049760.57098537
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56491567
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53397099
72mTOR signaling pathway_Homo sapiens_hsa041500.51980374
73Endocytosis_Homo sapiens_hsa041440.51472581
74Ras signaling pathway_Homo sapiens_hsa040140.51101998
75Inositol phosphate metabolism_Homo sapiens_hsa005620.50956006
76Circadian rhythm_Homo sapiens_hsa047100.49682797
77VEGF signaling pathway_Homo sapiens_hsa043700.49538997
78Insulin signaling pathway_Homo sapiens_hsa049100.47855838
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47706534
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46502503
81Endometrial cancer_Homo sapiens_hsa052130.45713924
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45424796
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44920413
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44872274
85Renal cell carcinoma_Homo sapiens_hsa052110.44653237
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44505201
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.44359894
88Ovarian steroidogenesis_Homo sapiens_hsa049130.44106892
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43962528
90Rap1 signaling pathway_Homo sapiens_hsa040150.43142785
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42452060
92Arginine and proline metabolism_Homo sapiens_hsa003300.41973708
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41968699
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40583529
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40254913
96Wnt signaling pathway_Homo sapiens_hsa043100.37882800
97Histidine metabolism_Homo sapiens_hsa003400.35842104
98Non-small cell lung cancer_Homo sapiens_hsa052230.35491348
99Arginine biosynthesis_Homo sapiens_hsa002200.34538819
100Fatty acid biosynthesis_Homo sapiens_hsa000610.33841973
101Prolactin signaling pathway_Homo sapiens_hsa049170.30630658
102Butanoate metabolism_Homo sapiens_hsa006500.30387623
103Chemokine signaling pathway_Homo sapiens_hsa040620.29668560
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27719262
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.27413636
106Mineral absorption_Homo sapiens_hsa049780.25295537
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24559076
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24123086
109Alzheimers disease_Homo sapiens_hsa050100.22434742
110Tight junction_Homo sapiens_hsa045300.22023741
111AMPK signaling pathway_Homo sapiens_hsa041520.22001766
112beta-Alanine metabolism_Homo sapiens_hsa004100.21334482
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.17341557
114HIF-1 signaling pathway_Homo sapiens_hsa040660.16644164

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