PNMT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to zinc ion (GO:0071294)9.79313153
2ketone biosynthetic process (GO:0042181)9.76686394
3progesterone metabolic process (GO:0042448)8.96854902
4hormone biosynthetic process (GO:0042446)8.66162240
5response to follicle-stimulating hormone (GO:0032354)8.48518310
6cellular response to interferon-alpha (GO:0035457)8.15354574
7androgen metabolic process (GO:0008209)7.29370547
8cellular response to growth hormone stimulus (GO:0071378)6.80086257
9cellular response to antibiotic (GO:0071236)6.61967586
10estrogen metabolic process (GO:0008210)6.54606499
11cellular response to epinephrine stimulus (GO:0071872)6.15453674
12adhesion of symbiont to host (GO:0044406)5.91469645
13regulation of female receptivity (GO:0045924)5.87519315
14proline biosynthetic process (GO:0006561)5.80177777
15protoporphyrinogen IX biosynthetic process (GO:0006782)5.76889851
16toxin metabolic process (GO:0009404)5.75742695
17negative regulation of cytosolic calcium ion concentration (GO:0051481)5.71859023
18response to epinephrine (GO:0071871)5.61062924
19protoporphyrinogen IX metabolic process (GO:0046501)5.49601953
20cellular response to gonadotropin stimulus (GO:0071371)5.39798825
21response to lead ion (GO:0010288)5.28442561
22female mating behavior (GO:0060180)5.21641020
23proline metabolic process (GO:0006560)4.93144940
24cellular response to toxic substance (GO:0097237)4.88438333
25creatine metabolic process (GO:0006600)4.74226392
26renal system process involved in regulation of blood volume (GO:0001977)4.72286058
27ribosomal small subunit assembly (GO:0000028)4.66524063
28response to leptin (GO:0044321)4.61982889
29phagocytosis, recognition (GO:0006910)4.53398216
30heme biosynthetic process (GO:0006783)4.50774958
31cellular ketone metabolic process (GO:0042180)4.50235162
32porphyrin-containing compound biosynthetic process (GO:0006779)4.49056313
33low-density lipoprotein particle clearance (GO:0034383)4.48134887
34heme metabolic process (GO:0042168)4.46961424
35negative regulation of erythrocyte differentiation (GO:0045647)4.32189985
36mating behavior (GO:0007617)4.30233897
37renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)4.29911694
38cellular response to dexamethasone stimulus (GO:0071549)4.28666372
39positive regulation of male gonad development (GO:2000020)4.23419502
40regulation of male gonad development (GO:2000018)4.22986263
41benzene-containing compound metabolic process (GO:0042537)4.20873821
42porphyrin-containing compound metabolic process (GO:0006778)4.16119700
43gonadal mesoderm development (GO:0007506)4.11993009
44steroid biosynthetic process (GO:0006694)4.05639529
45tetrapyrrole biosynthetic process (GO:0033014)4.03257335
46response to dexamethasone (GO:0071548)4.02574362
47regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.99150086
48oxaloacetate metabolic process (GO:0006107)3.96077818
49cellular hormone metabolic process (GO:0034754)3.89854169
50cytokine metabolic process (GO:0042107)3.88635140
51intracellular lipid transport (GO:0032365)3.86166532
52response to gonadotropin (GO:0034698)3.81036218
53erythrocyte maturation (GO:0043249)3.80761159
54valine metabolic process (GO:0006573)3.66175957
55cholesterol catabolic process (GO:0006707)3.65316247
56sterol catabolic process (GO:0016127)3.65316247
57response to corticosterone (GO:0051412)3.65096757
58response to insecticide (GO:0017085)3.62967614
59positive regulation of nitric-oxide synthase activity (GO:0051000)3.49394664
60potassium ion homeostasis (GO:0055075)3.44780925
61regulation of skeletal muscle contraction (GO:0014819)3.44097368
62response to growth hormone (GO:0060416)3.42499964
63potassium ion export (GO:0071435)3.39637156
64muscle cell cellular homeostasis (GO:0046716)3.39441654
65response to interferon-alpha (GO:0035455)3.36499628
66regulation of female gonad development (GO:2000194)3.35764604
67negative regulation of potassium ion transmembrane transport (GO:1901380)3.29812179
68chaperone-mediated protein transport (GO:0072321)3.28923912
69definitive hemopoiesis (GO:0060216)3.24329335
70proteasome assembly (GO:0043248)3.23701099
71positive regulation of systemic arterial blood pressure (GO:0003084)3.23063054
72cellular response to monoamine stimulus (GO:0071868)3.21992916
73cellular response to catecholamine stimulus (GO:0071870)3.21992916
74NADH metabolic process (GO:0006734)3.20246121
75inner mitochondrial membrane organization (GO:0007007)3.17191182
76neurotransmitter catabolic process (GO:0042135)3.15120414
77bile acid biosynthetic process (GO:0006699)3.12343425
78response to phenylpropanoid (GO:0080184)3.10666454
79respiratory electron transport chain (GO:0022904)3.08117065
80mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.07129712
81electron transport chain (GO:0022900)3.05548700
82ventricular cardiac muscle cell action potential (GO:0086005)3.05285489
83viral transcription (GO:0019083)3.03165624
84gas transport (GO:0015669)3.02331939
85C21-steroid hormone biosynthetic process (GO:0006700)21.5344341
86protein-cofactor linkage (GO:0018065)2.99776035
87ribosomal small subunit biogenesis (GO:0042274)2.99695212
88response to catecholamine (GO:0071869)2.99085300
89response to monoamine (GO:0071867)2.99085300
90positive regulation of triglyceride biosynthetic process (GO:0010867)2.98871675
91oxygen transport (GO:0015671)2.97831151
92translational termination (GO:0006415)2.96231267
93sterol metabolic process (GO:0016125)2.95123131
94pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.94448940
95mitochondrion transport along microtubule (GO:0047497)2.93506349
96establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.93506349
97NADP metabolic process (GO:0006739)2.91779972
98aggressive behavior (GO:0002118)2.91323147
99biotin metabolic process (GO:0006768)2.91317018
100sodium ion homeostasis (GO:0055078)2.88532795
101response to mineralocorticoid (GO:0051385)2.87942077
102response to vitamin E (GO:0033197)2.86497376
1032-oxoglutarate metabolic process (GO:0006103)2.84406264
104urinary tract smooth muscle contraction (GO:0014848)2.84216398
105regulation of mitochondrial translation (GO:0070129)2.83721927
106cardiac myofibril assembly (GO:0055003)2.83053366
107DNA topological change (GO:0006265)2.82317854
108DNA replication checkpoint (GO:0000076)2.79202452
109cellular response to metal ion (GO:0071248)2.78865997
110Leydig cell differentiation (GO:0033327)2.78346451
111response to cadmium ion (GO:0046686)2.78107242
112hemoglobin metabolic process (GO:0020027)2.77886308
113formation of translation preinitiation complex (GO:0001731)2.76872686
114vitamin D metabolic process (GO:0042359)2.75862414
115circadian sleep/wake cycle process (GO:0022410)2.75109686
116alpha-linolenic acid metabolic process (GO:0036109)2.72674953
117misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.72514458
118membrane repolarization during action potential (GO:0086011)2.69439877
119ATP biosynthetic process (GO:0006754)2.68973597
120tricarboxylic acid metabolic process (GO:0072350)2.67623167
121branched-chain amino acid metabolic process (GO:0009081)2.64482358
122actin-myosin filament sliding (GO:0033275)2.64282715
123muscle filament sliding (GO:0030049)2.64282715
124megakaryocyte development (GO:0035855)2.64008036
125ncRNA 3-end processing (GO:0043628)2.62726257
126cardiac muscle contraction (GO:0060048)2.61478533
127mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.61343498
128translational elongation (GO:0006414)2.61296991
129aerobic respiration (GO:0009060)2.60700864
130detection of molecule of bacterial origin (GO:0032490)2.60189383
131mammary gland epithelial cell differentiation (GO:0060644)2.59944793
132striated muscle contraction (GO:0006941)2.59426046
133skeletal muscle contraction (GO:0003009)2.55727897
134muscle organ morphogenesis (GO:0048644)2.55653749
135phosphorelay signal transduction system (GO:0000160)2.55237201
136hormone metabolic process (GO:0042445)2.54673616
137membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.54465626
138regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.54155966
139endocrine process (GO:0050886)2.54155966
140regulation of systemic arterial blood pressure by hormone (GO:0001990)2.54155966
141purine nucleoside monophosphate biosynthetic process (GO:0009127)2.53489046
142purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.53489046
143telomere maintenance via semi-conservative replication (GO:0032201)2.53438829
144oxidative phosphorylation (GO:0006119)2.53214573
145regulation of cholesterol storage (GO:0010885)2.51858101
146purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.50851749
147IMP metabolic process (GO:0046040)2.50317344
148ATP synthesis coupled proton transport (GO:0015986)2.50150975
149energy coupled proton transport, down electrochemical gradient (GO:0015985)2.50150975
150granulocyte differentiation (GO:0030851)2.46629148
151multicellular organismal aging (GO:0010259)2.46527767
152nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.46202629
153regulation of cholesterol biosynthetic process (GO:0045540)2.45551753
154viral life cycle (GO:0019058)2.44752947
155high-density lipoprotein particle remodeling (GO:0034375)2.44354692
156cellular response to inorganic substance (GO:0071241)2.44158992
157protein targeting to mitochondrion (GO:0006626)2.43498618
158IMP biosynthetic process (GO:0006188)2.43387168
159mitochondrial genome maintenance (GO:0000002)2.43198201
160translational initiation (GO:0006413)2.42857614
161peptidyl-histidine modification (GO:0018202)2.42409616
162erythrocyte development (GO:0048821)2.40992670
163maturation of SSU-rRNA (GO:0030490)2.40866707
164glutathione biosynthetic process (GO:0006750)2.40133246
165negative regulation of fatty acid transport (GO:2000192)2.39800961
166DNA strand elongation involved in DNA replication (GO:0006271)2.39101912
167adrenal gland development (GO:0030325)2.38053189
168purine nucleoside triphosphate biosynthetic process (GO:0009145)2.37696553
169ribonucleoside triphosphate biosynthetic process (GO:0009201)2.37642762
170establishment of protein localization to mitochondrial membrane (GO:0090151)2.37243020
171tetrapyrrole metabolic process (GO:0033013)2.37113704
172nonribosomal peptide biosynthetic process (GO:0019184)2.36799632
173sarcomere organization (GO:0045214)2.34954524
174cellular response to ketone (GO:1901655)2.34921961
175cochlea development (GO:0090102)2.33451992
176regulation of steroid biosynthetic process (GO:0050810)2.31172420
177positive regulation of monooxygenase activity (GO:0032770)2.29012798
178tricarboxylic acid cycle (GO:0006099)2.28708869
179myofibril assembly (GO:0030239)2.25152733
180cardiac muscle cell development (GO:0055013)2.24574717
181alcohol biosynthetic process (GO:0046165)2.24034928
182actin-mediated cell contraction (GO:0070252)2.23199176
183sterol transport (GO:0015918)2.22348321
184cholesterol transport (GO:0030301)2.22348321
185glucocorticoid biosynthetic process (GO:0006704)17.2822795
186estrogen biosynthetic process (GO:0006703)14.8999715
187glucocorticoid metabolic process (GO:0008211)14.0950014
188C21-steroid hormone metabolic process (GO:0008207)13.5573802
189androgen biosynthetic process (GO:0006702)13.1593584
190cellular response to cadmium ion (GO:0071276)12.6924852
191cellular response to follicle-stimulating hormone stimulus (GO:0071372)11.3960472

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.39014094
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.66835777
3CLOCK_20551151_ChIP-Seq_293T_Human4.18752610
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.97811317
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.84468738
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.53922144
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.38404678
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.05181642
9E2F7_22180533_ChIP-Seq_HELA_Human2.95246549
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.85813877
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.80520645
12ZNF263_19887448_ChIP-Seq_K562_Human2.80445631
13SRY_22984422_ChIP-ChIP_TESTIS_Rat2.73571547
14ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.73329410
15ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.65971674
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.65423009
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.58380273
18* EP300_21415370_ChIP-Seq_HL-1_Mouse2.55316921
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.52662988
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.48219494
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.38690971
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.37059490
23GATA1_22025678_ChIP-Seq_K562_Human2.33027113
24ETS1_20019798_ChIP-Seq_JURKAT_Human2.31056358
25ESR1_15608294_ChIP-ChIP_MCF-7_Human2.28975740
26ESR1_20079471_ChIP-ChIP_T-47D_Human2.22747689
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.20735386
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.16171397
29RARG_19884340_ChIP-ChIP_MEFs_Mouse2.15374877
30CDX2_19796622_ChIP-Seq_MESCs_Mouse2.13496638
31IKZF1_21737484_ChIP-ChIP_HCT116_Human2.04938572
32* GATA1_19941826_ChIP-Seq_K562_Human2.02468509
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.96894533
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.96894533
35HIF1A_21447827_ChIP-Seq_MCF-7_Human1.89894092
36XRN2_22483619_ChIP-Seq_HELA_Human1.86291181
37LXR_22158963_ChIP-Seq_LIVER_Mouse1.83141469
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.83075841
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.82664134
40BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.81694634
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.81620710
42MYC_19030024_ChIP-ChIP_MESCs_Mouse1.78219402
43EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.76519598
44* P68_20966046_ChIP-Seq_HELA_Human1.70500960
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.68892054
46ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.68834779
47CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.68672914
48* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.67164071
49TET1_21451524_ChIP-Seq_MESCs_Mouse1.67033463
50ESR1_21235772_ChIP-Seq_MCF-7_Human1.67028097
51EST1_17652178_ChIP-ChIP_JURKAT_Human1.66916279
52JARID2_20075857_ChIP-Seq_MESCs_Mouse1.66308771
53NCOR1_26117541_ChIP-Seq_K562_Human1.65942289
54TBX20_22328084_ChIP-Seq_HEART_Mouse1.65570090
55TBX20_22080862_ChIP-Seq_HEART_Mouse1.65570090
56SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.65473508
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.65133488
58SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.63995112
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.62863966
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.61387223
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.59642235
62RXR_22158963_ChIP-Seq_LIVER_Mouse1.59156875
63GABP_19822575_ChIP-Seq_HepG2_Human1.55845886
64PPARA_22158963_ChIP-Seq_LIVER_Mouse1.54722067
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.52087935
66EZH2_27304074_Chip-Seq_ESCs_Mouse1.51810488
67CDX2_20551321_ChIP-Seq_CACO-2_Human1.51627110
68FOXP1_21924763_ChIP-Seq_HESCs_Human1.51400326
69DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.50342022
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.50215152
71DCP1A_22483619_ChIP-Seq_HELA_Human1.50076746
72ISL1_27105846_Chip-Seq_CPCs_Mouse1.49651429
73SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.47800836
74SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.43780766
75ELF1_20517297_ChIP-Seq_JURKAT_Human1.42631944
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.41290356
77E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41088658
78CTCF_26484167_Chip-Seq_Bcells_Mouse1.39557248
79NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.38715316
80EGR1_19032775_ChIP-ChIP_M12_Human1.38128953
81BCOR_27268052_Chip-Seq_Bcells_Human1.38044495
82ELK4_26923725_Chip-Seq_MESODERM_Mouse1.37342775
83YY1_21170310_ChIP-Seq_MESCs_Mouse1.37113426
84ZNF274_21170338_ChIP-Seq_K562_Hela1.37000070
85POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36780309
86EED_16625203_ChIP-ChIP_MESCs_Mouse1.34791991
87ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34028678
88MTF2_20144788_ChIP-Seq_MESCs_Mouse1.32876250
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.31172675
90SMC4_20622854_ChIP-Seq_HELA_Human1.31063612
91CIITA_25753668_ChIP-Seq_RAJI_Human1.30142377
92PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28846859
93YY1_22570637_ChIP-Seq_MALME-3M_Human1.24166924
94NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23594076
95KDM5A_27292631_Chip-Seq_BREAST_Human1.22567671
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.22110453
97* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22101523
98CTCF_27219007_Chip-Seq_Bcells_Human1.21902667
99TTF2_22483619_ChIP-Seq_HELA_Human1.20857215
100CREB1_15753290_ChIP-ChIP_HEK293T_Human1.20436347
101* GATA2_19941826_ChIP-Seq_K562_Human1.20387538
102GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19455228
103CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19276232
104CREB1_26743006_Chip-Seq_LNCaP_Human1.18873267
105* LXR_22292898_ChIP-Seq_THP-1_Human1.18233757
106NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17979158
107CTCF_20526341_ChIP-Seq_ESCs_Human1.17613723
108MYC_22102868_ChIP-Seq_BL_Human1.17413201
109* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.17330511
110CTCF_18555785_ChIP-Seq_MESCs_Mouse1.15998611
111ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15099639
112TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.14699379
113MYCN_18555785_ChIP-Seq_MESCs_Mouse1.13864340
114MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.13536010
115CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12714464
116RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12463480
117SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12013317
118* E2F1_20622854_ChIP-Seq_HELA_Human1.11050487
119BCL6_27268052_Chip-Seq_Bcells_Human1.10973393
120SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10947296
121FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.10459331
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09706766
123JARID2_20064375_ChIP-Seq_MESCs_Mouse1.09260078
124GATA1_19941827_ChIP-Seq_MEL_Mouse1.08550584
125GABP_17652178_ChIP-ChIP_JURKAT_Human1.08262401
126FOXP3_21729870_ChIP-Seq_TREG_Human1.08181732
127ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06896211
128CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06882396
129* PHF8_20622854_ChIP-Seq_HELA_Human1.06038572
130NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05527845
131EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03968478
132GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.03763600
133CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03657479
134SCL_19346495_ChIP-Seq_HPC-7_Human1.03637228
135RARB_24833708_ChIP-Seq_LIVER_Mouse1.03457340
136PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.03269156
137* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03105989
138PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02664796
139YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01588112
140NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00887670
141CTCF_21964334_Chip-Seq_Bcells_Human1.00100047
142MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99791481
143TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99707360
144DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99489094
145HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.98563326
146TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97488565
147RARA_24833708_ChIP-Seq_LIVER_Mouse0.97044832
148NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96890198
149* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.94081186
150DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91097086
151SALL4_18804426_ChIP-ChIP_XEN_Mouse0.90558551
152* EZH2_27294783_Chip-Seq_ESCs_Mouse0.88805555
153ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88148151
154TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88035266
155EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.87685559
156* RING1B_27294783_Chip-Seq_ESCs_Mouse0.87033755
157SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86415803
158SUZ12_27294783_Chip-Seq_ESCs_Mouse0.86223738
159GATA4_21415370_ChIP-Seq_HL-1_Mouse0.86056879
160GF1_26923725_Chip-Seq_HPCs_Mouse0.83962899
161NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.82954887
162RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.81778942
163* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.81615553
164SMAD4_21741376_ChIP-Seq_EPCs_Human0.81578886
165RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81478464
166WT1_25993318_ChIP-Seq_PODOCYTE_Human0.81079040
167TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.80039051
168ELF1_17652178_ChIP-ChIP_JURKAT_Human0.79801521
169RNF2_27304074_Chip-Seq_ESCs_Mouse0.78984293
170RACK7_27058665_Chip-Seq_MCF-7_Human0.78657876
171* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.77807106
172TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76379567
173EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.75285269
174CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.74741326
175DNAJC2_21179169_ChIP-ChIP_NT2_Human0.74255347
176TP53_18474530_ChIP-ChIP_U2OS_Human0.72325281
177TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72225412
178POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.72225412
179THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.71924565
180WT1_19549856_ChIP-ChIP_CCG9911_Human0.71807659
181HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.71574047
182KDM2B_26808549_Chip-Seq_K562_Human0.71153985

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002909_abnormal_adrenal_gland7.53592545
2MP0000639_abnormal_adrenal_gland7.31172750
3MP0004147_increased_porphyrin_level5.35474551
4MP0005083_abnormal_biliary_tract4.60593952
5MP0004084_abnormal_cardiac_muscle4.30382541
6MP0003656_abnormal_erythrocyte_physiolo3.57294535
7MP0001765_abnormal_ion_homeostasis3.52727802
8MP0003123_paternal_imprinting3.30976244
9MP0003122_maternal_imprinting3.10944211
10MP0004036_abnormal_muscle_relaxation2.79831655
11* MP0000230_abnormal_systemic_arterial2.76334605
12MP0002822_catalepsy2.74553824
13MP0005636_abnormal_mineral_homeostasis2.55741781
14MP0004085_abnormal_heartbeat2.51010463
15MP0000749_muscle_degeneration2.49650616
16MP0008995_early_reproductive_senescence2.36169678
17MP0000751_myopathy2.30793388
18MP0008875_abnormal_xenobiotic_pharmacok2.13847886
19MP0006138_congestive_heart_failure2.12669617
20MP0005275_abnormal_skin_tensile2.06152254
21MP0005646_abnormal_pituitary_gland2.01664000
22MP0004087_abnormal_muscle_fiber2.00747092
23MP0006276_abnormal_autonomic_nervous2.00462442
24MP0010630_abnormal_cardiac_muscle1.99889236
25MP0005319_abnormal_enzyme/_coenzyme1.96418027
26MP0000678_abnormal_parathyroid_gland1.83732231
27MP0002837_dystrophic_cardiac_calcinosis1.82961828
28MP0000631_abnormal_neuroendocrine_gland1.80032744
29MP0004883_abnormal_blood_vessel1.77074571
30MP0003942_abnormal_urinary_system1.75201396
31MP0001544_abnormal_cardiovascular_syste1.70924452
32MP0005385_cardiovascular_system_phenoty1.70924452
33MP0003186_abnormal_redox_activity1.70093251
34MP0008004_abnormal_stomach_pH1.69465229
35MP0003638_abnormal_response/metabolism_1.66323156
36MP0004145_abnormal_muscle_electrophysio1.65463318
37MP0005330_cardiomyopathy1.64286361
38MP0003121_genomic_imprinting1.64179745
39MP0002972_abnormal_cardiac_muscle1.63454597
40MP0001661_extended_life_span1.60054739
41MP0002269_muscular_atrophy1.59093147
42MP0002938_white_spotting1.54108531
43MP0008058_abnormal_DNA_repair1.48857657
44MP0002127_abnormal_cardiovascular_syste1.48498827
45MP0005620_abnormal_muscle_contractility1.48424890
46MP0003221_abnormal_cardiomyocyte_apopto1.48259362
47MP0005670_abnormal_white_adipose1.47816075
48MP0008775_abnormal_heart_ventricle1.43249424
49MP0004484_altered_response_of1.42792140
50MP0004272_abnormal_basement_membrane1.39617622
51MP0002108_abnormal_muscle_morphology1.36152435
52MP0009053_abnormal_anal_canal1.35588683
53MP0004233_abnormal_muscle_weight1.35391231
54MP0003385_abnormal_body_wall1.22323096
55MP0001502_abnormal_circadian_rhythm1.21983101
56MP0005584_abnormal_enzyme/coenzyme_acti1.21974270
57MP0001756_abnormal_urination1.21756382
58MP0004270_analgesia1.21451162
59MP0000681_abnormal_thyroid_gland1.20899323
60MP0001545_abnormal_hematopoietic_system1.19831051
61MP0005397_hematopoietic_system_phenotyp1.19831051
62MP0003646_muscle_fatigue1.16923567
63MP0002132_abnormal_respiratory_system1.15685990
64MP0006035_abnormal_mitochondrial_morpho1.14784878
65MP0005451_abnormal_body_composition1.14752196
66MP0009780_abnormal_chondrocyte_physiolo1.11338166
67MP0008872_abnormal_physiological_respon1.11172903
68MP0004215_abnormal_myocardial_fiber1.10959012
69MP0002106_abnormal_muscle_physiology1.10626787
70* MP0000266_abnormal_heart_morphology1.09306936
71* MP0003953_abnormal_hormone_level1.08365452
72MP0004510_myositis1.05467272
73MP0003718_maternal_effect1.05295912
74MP0010368_abnormal_lymphatic_system1.05238961
75MP0000537_abnormal_urethra_morphology1.03922524
76MP0003786_premature_aging1.03211963
77MP0002254_reproductive_system_inflammat1.01854633
78MP0009643_abnormal_urine_homeostasis0.99966769
79MP0002249_abnormal_larynx_morphology0.99075050
80MP0003137_abnormal_impulse_conducting0.98953058
81MP0005503_abnormal_tendon_morphology0.97470019
82MP0004957_abnormal_blastocyst_morpholog0.97404528
83MP0010329_abnormal_lipoprotein_level0.97309915
84MP0000372_irregular_coat_pigmentation0.95459887
85MP0005220_abnormal_exocrine_pancreas0.93276012
86MP0005369_muscle_phenotype0.92394377
87MP0003693_abnormal_embryo_hatching0.92241158
88MP0001881_abnormal_mammary_gland0.91955238
89MP0004859_abnormal_synaptic_plasticity0.91539928
90MP0001879_abnormal_lymphatic_vessel0.87224914
91MP0008438_abnormal_cutaneous_collagen0.86115805
92MP0000747_muscle_weakness0.85991627
93MP0002139_abnormal_hepatobiliary_system0.85665898
94MP0005647_abnormal_sex_gland0.85654391
95MP0000343_altered_response_to0.85575210
96MP0005410_abnormal_fertilization0.85300097
97MP0005164_abnormal_response_to0.84806711
98MP0004130_abnormal_muscle_cell0.84371642
99MP0000750_abnormal_muscle_regeneration0.84207164
100MP0010234_abnormal_vibrissa_follicle0.84078835
101MP0005332_abnormal_amino_acid0.83504177
102MP0003948_abnormal_gas_homeostasis0.82961311
103MP0005595_abnormal_vascular_smooth0.82874998
104MP0006036_abnormal_mitochondrial_physio0.82672903
105MP0009250_abnormal_appendicular_skeleto0.81023831
106MP0005174_abnormal_tail_pigmentation0.79251412
107MP0008007_abnormal_cellular_replicative0.79152185
108MP0003111_abnormal_nucleus_morphology0.77765583
109MP0000759_abnormal_skeletal_muscle0.75970388
110MP0001119_abnormal_female_reproductive0.73810686
111MP0002160_abnormal_reproductive_system0.73761728
112MP0010030_abnormal_orbit_morphology0.73328212
113MP0000538_abnormal_urinary_bladder0.73042797
114MP0003172_abnormal_lysosome_physiology0.72762391
115MP0005645_abnormal_hypothalamus_physiol0.72058154
116MP0001529_abnormal_vocalization0.71669518
117MP0005464_abnormal_platelet_physiology0.70756671
118MP0000013_abnormal_adipose_tissue0.69231398
119MP0000467_abnormal_esophagus_morphology0.67701491
120MP0003828_pulmonary_edema0.67562747
121MP0005171_absent_coat_pigmentation0.67548088
122MP0003115_abnormal_respiratory_system0.67217408
123MP0002078_abnormal_glucose_homeostasis0.66644785
124MP0009840_abnormal_foam_cell0.66267447
125MP0005058_abnormal_lysosome_morphology0.65132770
126MP0003698_abnormal_male_reproductive0.65001308
127MP0003566_abnormal_cell_adhesion0.64918326
128MP0005623_abnormal_meninges_morphology0.63721305
129MP0003941_abnormal_skin_development0.63433961
130MP0001177_atelectasis0.62549119
131MP0002638_abnormal_pupillary_reflex0.62374604
132MP0002733_abnormal_thermal_nociception0.62271916
133MP0006292_abnormal_olfactory_placode0.61957021
134MP0003705_abnormal_hypodermis_morpholog0.61720686
135MP0003635_abnormal_synaptic_transmissio0.61297415
136MP0004858_abnormal_nervous_system0.61171941
137MP0008789_abnormal_olfactory_epithelium0.60739775
138MP0002080_prenatal_lethality0.60511624
139MP0001958_emphysema0.60404311
140MP0008932_abnormal_embryonic_tissue0.59754975
141MP0009697_abnormal_copulation0.59316095
142MP0003567_abnormal_fetal_cardiomyocyte0.59101450
143MP0002295_abnormal_pulmonary_circulatio0.58302564
144MP0001970_abnormal_pain_threshold0.56090994
145MP0009379_abnormal_foot_pigmentation0.55784573
146MP0005452_abnormal_adipose_tissue0.55427501
147MP0002118_abnormal_lipid_homeostasis0.55249752
148MP0001614_abnormal_blood_vessel0.53828797
149MP0003300_gastrointestinal_ulcer0.53367388
150MP0003878_abnormal_ear_physiology0.52402212
151MP0005377_hearing/vestibular/ear_phenot0.52402212
152MP0009384_cardiac_valve_regurgitation0.51598727
153MP0005535_abnormal_body_temperature0.51350264
154MP0000534_abnormal_ureter_morphology0.50304162
155MP0009642_abnormal_blood_homeostasis0.50228938
156MP0008770_decreased_survivor_rate0.48464258
157MP0002282_abnormal_trachea_morphology0.48036941
158MP0002332_abnormal_exercise_endurance0.46449218

Predicted human phenotypes

RankGene SetZ-score
1Hyperaldosteronism (HP:0000859)8.84719357
2Hypoplasia of the uterus (HP:0000013)8.83790747
3Abnormality of renin-angiotensin system (HP:0000847)8.69121682
4Aplasia/hypoplasia of the uterus (HP:0008684)6.86406321
5Neonatal onset (HP:0003623)6.62059963
6Increased circulating renin level (HP:0000848)6.61457772
7Abnormality of the heme biosynthetic pathway (HP:0010472)5.70375285
8Orthostatic hypotension (HP:0001278)5.58698758
9Reticulocytosis (HP:0001923)5.23868425
10Sex reversal (HP:0012245)5.15632210
11Abnormal sex determination (HP:0012244)5.15632210
12Hyperthyroidism (HP:0000836)5.03087578
13Adrenal overactivity (HP:0002717)4.72037599
14Accelerated skeletal maturation (HP:0005616)4.46046955
15Abnormality of potassium homeostasis (HP:0011042)4.35066280
16Muscle fiber inclusion bodies (HP:0100299)4.18377106
17Abnormal number of erythroid precursors (HP:0012131)4.11257886
18Clitoromegaly (HP:0000057)4.04326892
19Hypokalemia (HP:0002900)4.00364045
20Hyperkalemia (HP:0002153)3.95846452
21Abnormality of reticulocytes (HP:0004312)3.83396478
22Abnormality of cells of the erythroid lineage (HP:0012130)3.83230981
23Cholelithiasis (HP:0001081)3.82484187
24Truncus arteriosus (HP:0001660)3.69683633
25Testicular neoplasm (HP:0010788)3.58523939
26Myopathic facies (HP:0002058)3.53648489
27Hypertensive crisis (HP:0100735)3.35946893
28Abnormal gallbladder morphology (HP:0012437)3.33644378
29Cholecystitis (HP:0001082)3.31544670
30Abnormal gallbladder physiology (HP:0012438)3.31544670
31Hypoparathyroidism (HP:0000829)3.29669276
32Ventricular fibrillation (HP:0001663)3.29065924
33Exercise-induced muscle cramps (HP:0003710)3.21608111
34Episodic fever (HP:0001954)3.20786640
35Centrally nucleated skeletal muscle fibers (HP:0003687)3.20421753
36Neonatal hypoglycemia (HP:0001998)3.17902717
37Abnormality of the tricuspid valve (HP:0001702)3.16049599
38Seborrheic dermatitis (HP:0001051)3.07739731
39Abnormality of the parathyroid morphology (HP:0011766)3.07276838
40Myoglobinuria (HP:0002913)2.99556734
41Progressive muscle weakness (HP:0003323)2.94310727
42Ependymoma (HP:0002888)2.90379324
43Microvesicular hepatic steatosis (HP:0001414)2.87420670
44Cerebral palsy (HP:0100021)2.76066665
45Azoospermia (HP:0000027)2.74137226
46Spontaneous abortion (HP:0005268)2.71096211
47Poikilocytosis (HP:0004447)2.69815901
48Abnormality of the clitoris (HP:0000056)2.68443881
49Paralysis (HP:0003470)2.68124700
50Testicular atrophy (HP:0000029)2.60879273
51Atelectasis (HP:0100750)2.55461364
52Sudden death (HP:0001699)2.53094089
53Hyponatremia (HP:0002902)2.50812677
54Gonadal dysgenesis (HP:0000133)2.49073097
55Hepatoblastoma (HP:0002884)2.47921067
56Progressive macrocephaly (HP:0004481)2.46915754
57Astrocytoma (HP:0009592)2.46135902
58Abnormality of the astrocytes (HP:0100707)2.46135902
59Increased serum pyruvate (HP:0003542)2.44871312
60Abnormality of glycolysis (HP:0004366)2.44871312
61Abnormal autonomic nervous system physiology (HP:0012332)2.42035908
62Ulnar deviation of the wrist (HP:0003049)2.38947369
63Abnormality of the gallbladder (HP:0005264)2.36550352
64Distal lower limb muscle weakness (HP:0009053)2.34472529
65Increased serum ferritin (HP:0003281)2.31328521
66Precocious puberty (HP:0000826)2.30035845
67Hyperglycinuria (HP:0003108)2.28536116
68Round ear (HP:0100830)2.27775646
69Rhabdomyolysis (HP:0003201)2.27501131
70Exercise-induced myalgia (HP:0003738)2.23965386
71Aplasia/Hypoplasia of the earlobes (HP:0009906)2.23400640
72Abnormality of the aortic arch (HP:0012303)2.22309725
73Bifid scrotum (HP:0000048)2.22037628
74Primary adrenal insufficiency (HP:0008207)2.20940502
75Prolonged QT interval (HP:0001657)2.18995322
76Abnormality of transition element cation homeostasis (HP:0011030)2.17852071
77Calf muscle hypertrophy (HP:0008981)2.15205511
78Abnormality of sodium homeostasis (HP:0010931)2.13533779
79Myokymia (HP:0002411)2.13038960
80Atrial fibrillation (HP:0005110)2.12049006
81Pallor (HP:0000980)2.08439251
82Lipoatrophy (HP:0100578)2.05341969
83Venous insufficiency (HP:0005293)2.03325091
84Multiple enchondromatosis (HP:0005701)2.02089459
85Muscle hypertrophy of the lower extremities (HP:0008968)2.01010953
86Neoplasm of the adrenal gland (HP:0100631)2.00819385
87Mitochondrial inheritance (HP:0001427)2.00719268
88Polycythemia (HP:0001901)2.00117264
89Broad alveolar ridges (HP:0000187)2.00033943
90Decreased circulating renin level (HP:0003351)11.9543018
91Enlarged penis (HP:0000040)11.0409510
92Renal salt wasting (HP:0000127)10.7880968
93Short middle phalanx of the 5th finger (HP:0004220)1.99526724
94Primary atrial arrhythmia (HP:0001692)1.98691641
95Syncope (HP:0001279)1.98181138
96Glioma (HP:0009733)1.97930180
97Lipid accumulation in hepatocytes (HP:0006561)1.97572499
98Infantile muscular hypotonia (HP:0008947)1.97075297
99Aplasia of the musculature (HP:0100854)1.94841380
100Hypotension (HP:0002615)1.94451315
101Bundle branch block (HP:0011710)1.94161301
102Ileus (HP:0002595)1.93722101
103Renal Fanconi syndrome (HP:0001994)1.93584360
104Distal arthrogryposis (HP:0005684)1.91723812
105Progressive microcephaly (HP:0000253)1.91229728
106Cerebral edema (HP:0002181)1.90314333
107Supraventricular tachycardia (HP:0004755)1.90197704
108Supraventricular arrhythmia (HP:0005115)1.89113773
109Palpitations (HP:0001962)1.88906841
110Bulbar palsy (HP:0001283)1.87617384
111Bowel incontinence (HP:0002607)1.87311930
112Gout (HP:0001997)1.86725739
113Lactic acidosis (HP:0003128)1.83237948
114Hypothermia (HP:0002045)1.82462069
115Shawl scrotum (HP:0000049)1.82262866
116Increased hepatocellular lipid droplets (HP:0006565)1.82066030
117Epiphyseal stippling (HP:0010655)1.81409102
118Distal lower limb amyotrophy (HP:0008944)1.80634898
119Increased CSF lactate (HP:0002490)1.79477411
120Abnormality of iron homeostasis (HP:0011031)1.79250168
121Ankle clonus (HP:0011448)1.79044767
122Flat capital femoral epiphysis (HP:0003370)1.76853753
123Abnormal delivery (HP:0001787)1.75986272
124Rimmed vacuoles (HP:0003805)1.74997848
125Increased muscle lipid content (HP:0009058)1.74799515
126Areflexia of lower limbs (HP:0002522)1.74738761
127Short 5th finger (HP:0009237)1.74590118
128Spastic tetraparesis (HP:0001285)1.74041692
129Diastasis recti (HP:0001540)1.73368218
130Male pseudohermaphroditism (HP:0000037)1.73085536
131Venous abnormality (HP:0002624)1.72861537
132Abnormal large intestine physiology (HP:0012700)1.71826376
133Type 1 muscle fiber predominance (HP:0003803)1.71170778
134Abnormal spermatogenesis (HP:0008669)1.69278016
135Abnormal pancreas size (HP:0012094)1.66825026
136Hepatic necrosis (HP:0002605)1.65698660
137Ventricular tachycardia (HP:0004756)1.62023263
138Bifid tongue (HP:0010297)1.60764546
139Pheochromocytoma (HP:0002666)1.60745926
140Increased connective tissue (HP:0009025)1.59647804
141Muscle stiffness (HP:0003552)1.59514664
142Myotonia (HP:0002486)1.59281012
143Hypospadias (HP:0000047)1.57578278
144Muscle fiber splitting (HP:0003555)1.55403568
145Abnormality of the calf musculature (HP:0001430)1.54909594
146Abnormal mitochondria in muscle tissue (HP:0008316)1.52643532
147Decreased testicular size (HP:0008734)1.50827606
148Premature ovarian failure (HP:0008209)1.50510704
149Dilated cardiomyopathy (HP:0001644)1.49081640
150Ragged-red muscle fibers (HP:0003200)1.48413514
151Patent foramen ovale (HP:0001655)1.47810310
152Nemaline bodies (HP:0003798)1.47062087
153EMG: myopathic abnormalities (HP:0003458)1.46479625
154Acute necrotizing encephalopathy (HP:0006965)1.46046406
155Atrioventricular block (HP:0001678)1.45451601
156Breech presentation (HP:0001623)1.44192531
157Right ventricular cardiomyopathy (HP:0011663)1.43965466
158Hyporeflexia of lower limbs (HP:0002600)1.43780764
159Abnormality of secondary sexual hair (HP:0009888)1.42105162
160Abnormality of the axillary hair (HP:0100134)1.42105162
161Lymphangioma (HP:0100764)1.41887188
162Neck muscle weakness (HP:0000467)1.41278110
163Hypoglycemic coma (HP:0001325)1.40882290
164Septate vagina (HP:0001153)1.40435427
165Ketoacidosis (HP:0001993)1.39453203
166Diaphragmatic weakness (HP:0009113)1.38945314
167Exercise intolerance (HP:0003546)1.38139954
168Increased intramyocellular lipid droplets (HP:0012240)1.37827960
169Abnormal EKG (HP:0003115)1.37054366
170Bicornuate uterus (HP:0000813)1.36550791
171Acute encephalopathy (HP:0006846)1.35787036
172Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.35049049
173Conjunctival hamartoma (HP:0100780)1.34400696
174Vomiting (HP:0002013)1.34165214
175Hepatocellular necrosis (HP:0001404)1.33967095

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT37.83863746
2OBSCN5.15962925
3TRIB34.46097519
4MYLK3.88165116
5PINK13.19508770
6PKN23.12151594
7PLK43.00490542
8MATK2.92860747
9ERN12.70210983
10TIE12.49765284
11LIMK12.46787802
12MAP3K92.36526835
13BCKDK2.34988090
14MAPKAPK32.23141841
15WNK42.17750401
16EIF2AK11.98508097
17CLK11.96050707
18NME21.86657758
19MST41.81176949
20EPHB21.74770153
21ILK1.72605524
22PIK3CA1.64272749
23TESK11.58438028
24PRKCI1.57691754
25MAP3K111.56195490
26LRRK21.53509918
27CDK71.53193347
28RPS6KB21.51423089
29DMPK1.49667508
30PTK2B1.49338280
31CDC71.48662813
32MAP4K21.45819448
33MAP2K61.44871389
34EEF2K1.43493083
35VRK21.28910098
36PTK61.28086075
37PRKD31.27260796
38TTN1.21856305
39KDR1.18611299
40NME11.17913240
41WEE11.13961351
42SRPK11.13099482
43STK161.12963041
44BRSK21.11530617
45PAK61.10809436
46ZAK1.10602937
47RIPK11.10088301
48SIK11.06620708
49TAOK31.05393173
50RPS6KA51.05176051
51DAPK21.04929610
52TTK1.04927232
53MAPK121.04085067
54CDC42BPA1.01762361
55PHKG21.01414982
56PHKG11.01414982
57FGFR10.98278927
58STK240.97753494
59TAOK20.96353211
60BMX0.96019427
61PDGFRA0.95820416
62FLT30.94848086
63TNK20.93308974
64EPHA40.91014785
65NTRK10.90820587
66MAP2K30.90747443
67FGFR40.88455287
68LATS20.88190185
69BRSK10.85721504
70RIPK40.85015841
71STK390.84318475
72FER0.81212495
73NTRK30.79675302
74ROCK10.78728739
75PRKG20.78583417
76SIK30.78283980
77TLK10.78255345
78DAPK10.77526706
79CAMK1D0.76256236
80KSR20.76145868
81PAK20.74601062
82MTOR0.74144121
83ARAF0.73598972
84DAPK30.72462903
85CAMK10.72428686
86MAPK30.70031165
87PAK30.69226470
88MAP2K40.68799455
89PTK20.65145364
90MINK10.63584209
91PRKD10.62902459
92MAPK150.61810105
93MET0.61666871
94MAPK130.59281645
95MAP3K80.57543587
96MAPKAPK50.57079050
97WNK10.56771290
98CDK30.56725805
99MAP2K10.56139354
100CDK11A0.55114295
101PRPF4B0.54497562
102PLK10.54256149
103ERBB20.54014964
104KSR10.53598911
105PRKACA0.53126614
106TESK20.52579955
107NEK10.52320729
108BTK0.51136013
109TEC0.50694659
110UHMK10.49449422
111PIM20.48967813
112SGK10.48346444
113MAPK110.47758834
114DYRK20.45806974
115CAMK2D0.44985534
116CAMK2A0.44151494
117CSNK2A10.43588722
118BRAF0.43419299
119ROCK20.43072219
120ATR0.42426181
121NUAK10.42392255
122PRKACB0.42103303
123CHEK20.41973683
124CAMK2G0.41944013
125LMTK20.41856729
126BCR0.40834215
127FGFR20.40802433
128MAP3K70.40700849
129CHEK10.40567480
130MAPK80.40229124
131MARK10.40073600
132PAK40.39912770
133CDK120.39831104
134TAOK10.39121024
135TGFBR10.38690013
136AURKA0.38175606
137PRKACG0.38036544
138CAMK40.36715317
139TGFBR20.35354270
140MAP3K100.35065099
141INSRR0.34025661
142CDK140.33874553
143PDK30.31966168
144PDK40.31966168
145RAF10.31065832
146MAP3K20.30794301
147MUSK0.30656169
148PRKCH0.30236399
149CDK180.29417648
150IGF1R0.29380144
151CAMK1G0.29017975
152DYRK1A0.28796361
153CAMK2B0.27235690
154PIK3CG0.26519151
155EGFR0.25846985
156CDK150.25075135
157ALK0.25026672
158AKT20.24647801
159RPS6KA30.23229733
160PRKAA20.22979018

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid hormone biosynthesis_Homo sapiens_hsa001407.47061850
2Aldosterone synthesis and secretion_Homo sapiens_hsa049255.85043934
3Ovarian steroidogenesis_Homo sapiens_hsa049134.69571247
4Sulfur relay system_Homo sapiens_hsa041224.12159823
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.18101443
6Fatty acid metabolism_Homo sapiens_hsa012122.79127509
7DNA replication_Homo sapiens_hsa030302.70624023
8Fatty acid degradation_Homo sapiens_hsa000712.61129161
9Cardiac muscle contraction_Homo sapiens_hsa042602.54442200
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.47373099
11Parkinsons disease_Homo sapiens_hsa050122.24080062
12Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.18091170
13Oxidative phosphorylation_Homo sapiens_hsa001902.15167704
14Propanoate metabolism_Homo sapiens_hsa006402.13097815
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.04937016
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.04650454
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.96859966
18Homologous recombination_Homo sapiens_hsa034401.94275120
19Carbon metabolism_Homo sapiens_hsa012001.80624558
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.80505956
21Mismatch repair_Homo sapiens_hsa034301.79729910
22Arginine and proline metabolism_Homo sapiens_hsa003301.75132673
23Pyruvate metabolism_Homo sapiens_hsa006201.74420312
24Base excision repair_Homo sapiens_hsa034101.69482560
25Fat digestion and absorption_Homo sapiens_hsa049751.66037091
26Alzheimers disease_Homo sapiens_hsa050101.65547768
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.63915201
28RNA polymerase_Homo sapiens_hsa030201.63266462
29One carbon pool by folate_Homo sapiens_hsa006701.60902333
30Vitamin digestion and absorption_Homo sapiens_hsa049771.57730432
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.54252242
32Fatty acid biosynthesis_Homo sapiens_hsa000611.53336337
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.52592249
34Dilated cardiomyopathy_Homo sapiens_hsa054141.50131506
35Proteasome_Homo sapiens_hsa030501.46936831
36PPAR signaling pathway_Homo sapiens_hsa033201.46551075
37Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.42938699
38Huntingtons disease_Homo sapiens_hsa050161.36465225
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.34580257
40Fanconi anemia pathway_Homo sapiens_hsa034601.29597478
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.26806844
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.26534240
43ABC transporters_Homo sapiens_hsa020101.22773036
44Purine metabolism_Homo sapiens_hsa002301.22202437
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16406985
46* Tyrosine metabolism_Homo sapiens_hsa003501.09677369
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.06481947
48Bile secretion_Homo sapiens_hsa049761.05747497
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.01283177
50Vitamin B6 metabolism_Homo sapiens_hsa007501.01218578
51Pyrimidine metabolism_Homo sapiens_hsa002400.99782945
52Arginine biosynthesis_Homo sapiens_hsa002200.99526842
53Butanoate metabolism_Homo sapiens_hsa006500.99129340
54Fructose and mannose metabolism_Homo sapiens_hsa000510.98617731
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92987123
56RNA transport_Homo sapiens_hsa030130.92692820
57Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92135861
58Fatty acid elongation_Homo sapiens_hsa000620.90985985
59Biosynthesis of amino acids_Homo sapiens_hsa012300.88927197
60Steroid biosynthesis_Homo sapiens_hsa001000.87693215
61N-Glycan biosynthesis_Homo sapiens_hsa005100.84178444
62Renin secretion_Homo sapiens_hsa049240.82755035
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.81460318
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78400148
65Nucleotide excision repair_Homo sapiens_hsa034200.73046820
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.71896586
67beta-Alanine metabolism_Homo sapiens_hsa004100.70655890
68Glycerophospholipid metabolism_Homo sapiens_hsa005640.70235826
69Other glycan degradation_Homo sapiens_hsa005110.65182425
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64194728
71RNA degradation_Homo sapiens_hsa030180.61650007
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61150552
73Tryptophan metabolism_Homo sapiens_hsa003800.60744182
74cAMP signaling pathway_Homo sapiens_hsa040240.60202657
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60010439
76Selenocompound metabolism_Homo sapiens_hsa004500.59961710
77Hedgehog signaling pathway_Homo sapiens_hsa043400.56951535
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55309400
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55208842
80mRNA surveillance pathway_Homo sapiens_hsa030150.54627646
81Circadian entrainment_Homo sapiens_hsa047130.53035583
82Phenylalanine metabolism_Homo sapiens_hsa003600.51566677
83Histidine metabolism_Homo sapiens_hsa003400.50995993
84Glucagon signaling pathway_Homo sapiens_hsa049220.50502865
85Nitrogen metabolism_Homo sapiens_hsa009100.48756117
86Sulfur metabolism_Homo sapiens_hsa009200.48625953
87VEGF signaling pathway_Homo sapiens_hsa043700.47464960
88AMPK signaling pathway_Homo sapiens_hsa041520.46969918
89Focal adhesion_Homo sapiens_hsa045100.46275719
90Oxytocin signaling pathway_Homo sapiens_hsa049210.46209092
91Spliceosome_Homo sapiens_hsa030400.45662230
92Peroxisome_Homo sapiens_hsa041460.45547448
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45245249
94Asthma_Homo sapiens_hsa053100.43124658
95mTOR signaling pathway_Homo sapiens_hsa041500.42769778
96Taste transduction_Homo sapiens_hsa047420.42653878
97Regulation of autophagy_Homo sapiens_hsa041400.41983908
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38504572
99Folate biosynthesis_Homo sapiens_hsa007900.38206489
100* Metabolic pathways_Homo sapiens_hsa011000.37975259
101Synaptic vesicle cycle_Homo sapiens_hsa047210.37020344
102Basal transcription factors_Homo sapiens_hsa030220.37010395
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35741832
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.35552288
105Prolactin signaling pathway_Homo sapiens_hsa049170.35022080
106Non-homologous end-joining_Homo sapiens_hsa034500.34616941
107Basal cell carcinoma_Homo sapiens_hsa052170.34553021
108HIF-1 signaling pathway_Homo sapiens_hsa040660.34119335
109Olfactory transduction_Homo sapiens_hsa047400.34021840
110Dopaminergic synapse_Homo sapiens_hsa047280.33584598
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.33477347
112Insulin resistance_Homo sapiens_hsa049310.32647250
113Acute myeloid leukemia_Homo sapiens_hsa052210.32307102
114Glycerolipid metabolism_Homo sapiens_hsa005610.30298105
115Lysine degradation_Homo sapiens_hsa003100.29848045
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29614702
117Tight junction_Homo sapiens_hsa045300.28577675
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.28450045
119Melanogenesis_Homo sapiens_hsa049160.28372762
120Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27961726
121Galactose metabolism_Homo sapiens_hsa000520.27317543
122Proteoglycans in cancer_Homo sapiens_hsa052050.26041002
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.25880779
124Prion diseases_Homo sapiens_hsa050200.25756436
125Hippo signaling pathway_Homo sapiens_hsa043900.24321725
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24200626
127Cocaine addiction_Homo sapiens_hsa050300.22279123
128Calcium signaling pathway_Homo sapiens_hsa040200.22178634
129Pentose phosphate pathway_Homo sapiens_hsa000300.22048645
130Amphetamine addiction_Homo sapiens_hsa050310.19192311
131Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19117413
132Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.18751943
133Glutathione metabolism_Homo sapiens_hsa004800.18724691
134Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.17496361
135Insulin signaling pathway_Homo sapiens_hsa049100.17333587
136Chemical carcinogenesis_Homo sapiens_hsa052040.17204124
137Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.15801065
138Ribosome_Homo sapiens_hsa030100.14610292
139Starch and sucrose metabolism_Homo sapiens_hsa005000.12247139
140Insulin secretion_Homo sapiens_hsa049110.12240368
141Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.10650468
142TGF-beta signaling pathway_Homo sapiens_hsa043500.08964757
143Linoleic acid metabolism_Homo sapiens_hsa005910.08646576
144Adherens junction_Homo sapiens_hsa045200.08021519
145Cysteine and methionine metabolism_Homo sapiens_hsa002700.07845210
146Long-term potentiation_Homo sapiens_hsa047200.07732486
147Regulation of actin cytoskeleton_Homo sapiens_hsa048100.07616950
148ECM-receptor interaction_Homo sapiens_hsa045120.07556699
149Thyroid hormone synthesis_Homo sapiens_hsa049180.06831897
150Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.06809944
151Salivary secretion_Homo sapiens_hsa049700.06241279
152Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.06090432
153Morphine addiction_Homo sapiens_hsa050320.05810334

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